MCID: LFF001
MIFTS: 39

Loeffler Endocarditis

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Loeffler Endocarditis

MalaCards integrated aliases for Loeffler Endocarditis:

Name: Loeffler Endocarditis 11 58 14 75
Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy 71
Eosinophilic Endomyocardial Disease 11
Eosinophilic Endocarditis 58
Loeffler's Endocarditis 71

Characteristics:


Age Of Onset:

Adolescent,Adult,Childhood 58

Classifications:



External Ids:

Disease Ontology 11 DOID:396
NCIt 49 C27044
SNOMED-CT 68 33258008
ICD10 31 I42.3
ICD10 via Orphanet 32 I42.3
UMLS via Orphanet 72 C0206143
Orphanet 58 ORPHA75566
UMLS 71 C0206143 C0264834

Summaries for Loeffler Endocarditis

Orphanet: 58 A rare restrictive cardiomyopathy characterized by hypereosinophilia and fibrous thickening of the endocardium, with usually large thrombi against the ventricle walls, that can lead to cardiovascular complications such as heart failure and thromboembolism. It manifests with symptoms like edema, fatigue and shortness of breath. It is usually secondary to eosinophil-associated tissue damage and is associated with idiopathic hypereosinophilic syndrome, chronic eosinophilic leukemia, carcinoma, or lymphoma.

MalaCards based summary: Loeffler Endocarditis, also known as primary eosinophilic endomyocardial restrictive cardiomyopathy, is related to primary hypereosinophilic syndrome and echinococcosis. An important gene associated with Loeffler Endocarditis is FIP1L1 (Factor Interacting With PAPOLA And CPSF1), and among its related pathways/superpathways are IL3-mediated signaling events and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Affiliated tissues include heart, thyroid and lung, and related phenotypes are eosinophilia and restrictive cardiomyopathy

Disease Ontology: 11 A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils.

Wikipedia: 75 Loeffler endocarditis is a form of heart disease characterized by a stiffened, poorly-functioning heart... more...

Related Diseases for Loeffler Endocarditis

Diseases related to Loeffler Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 primary hypereosinophilic syndrome 30.3 PDGFRA FIP1L1
2 echinococcosis 29.9 RNASE3 IL5
3 hypereosinophilic syndrome 29.9 RNASE3 PRG2 PDGFRA IL5 IL3 FIP1L1
4 mononeuritis multiplex 29.8 IL5 FIP1L1
5 granulomatosis with polyangiitis 29.8 RNASE3 IL5 FIP1L1
6 restrictive cardiomyopathy 29.6 TNNT2 RNASE3 RNASE2 PDGFRA FIP1L1
7 hypereosinophilic syndrome, idiopathic 29.5 PDGFRA IL5 IL3 FIP1L1
8 chronic eosinophilic leukemia 29.5 PDGFRA IL5 IL3 FIP1L1
9 endomyocardial fibrosis 29.1 RNASE3 RNASE2 PRG2 PDGFRA IL5 FIP1L1
10 churg-strauss syndrome 29.1 THBD RNASE3 PRG2 IL5 IL3
11 asthma 28.8 RNASE3 RNASE2 PRG2 IL5 IL3
12 pdgfra-associated chronic eosinophilic leukemia 11.2
13 endocarditis 10.8
14 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.2 PDGFRA FIP1L1
15 stress polycythemia 10.2 PDGFRA FIP1L1
16 heart disease 10.2
17 mitral valve insufficiency 10.2
18 sm-ahnmd 10.2 PDGFRA FIP1L1
19 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.2 PDGFRA FIP1L1
20 indolent systemic mastocytosis 10.2 PDGFRA FIP1L1
21 systemic mastocytosis 10.2 PDGFRA FIP1L1
22 aggressive systemic mastocytosis 10.1 PDGFRA FIP1L1
23 persistent mild asthma 10.1 RNASE3 IL3
24 persistent severe asthma 10.1 RNASE3 IL5
25 thunderstorm triggered asthma 10.1 RNASE3 IL5
26 cough variant asthma 10.0 RNASE3 IL5
27 near-fatal asthma 10.0 RNASE3 IL5
28 aspirin-induced respiratory disease 10.0 RNASE3 IL5
29 kimura disease 10.0 RNASE3 IL5
30 chronic leukemia 10.0 PDGFRA FIP1L1
31 intermittent asthma 10.0 RNASE3 IL5
32 elephantiasis 10.0 RNASE3 IL5
33 vasomotor rhinitis 10.0 RNASE3 IL5
34 cardiac conduction defect 10.0
35 systemic lupus erythematosus 10.0
36 cardiomyopathy, familial hypertrophic, 1 10.0
37 lymphoma, hodgkin, classic 10.0
38 stroke, ischemic 10.0
39 systemic lupus erythematosus 1 10.0
40 leukemia, acute lymphoblastic 10.0
41 cysticercosis 10.0
42 filariasis 10.0
43 hypertrophic cardiomyopathy 10.0
44 alveolar echinococcosis 10.0
45 filarial elephantiasis 10.0
46 antiphospholipid syndrome 10.0
47 hydranencephaly 10.0
48 congestive heart failure 10.0
49 myocarditis 10.0
50 lupus erythematosus 10.0

Graphical network of the top 20 diseases related to Loeffler Endocarditis:



Diseases related to Loeffler Endocarditis

Symptoms & Phenotypes for Loeffler Endocarditis

Human phenotypes related to Loeffler Endocarditis:

58 30 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 eosinophilia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001880
2 restrictive cardiomyopathy 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001723
3 abnormal thrombosis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001977
4 myocardial eosinophilic infiltration 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0031323
5 fatigue 58 30 Frequent (33%) Frequent (79-30%)
HP:0012378
6 congestive heart failure 58 30 Frequent (33%) Frequent (79-30%)
HP:0001635
7 left ventricular hypertrophy 58 30 Frequent (33%) Frequent (79-30%)
HP:0001712
8 dyspnea 58 30 Frequent (33%) Frequent (79-30%)
HP:0002094
9 chest pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0100749
10 weight loss 58 30 Frequent (33%) Frequent (79-30%)
HP:0001824
11 palpitations 58 30 Frequent (33%) Frequent (79-30%)
HP:0001962
12 abnormal cardiomyocyte morphology 58 30 Frequent (33%) Frequent (79-30%)
HP:0031331
13 left ventricular diastolic dysfunction 58 30 Frequent (33%) Frequent (79-30%)
HP:0025168
14 mitral regurgitation 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001653
15 cough 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0012735
16 right bundle branch block 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0011712
17 myocardial fibrosis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001685
18 t-wave inversion 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0010872
19 left atrial enlargement 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0031295
20 endocardial fibrosis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0006685
21 abnormal morphology of the chordae tendinae of the mitral valve 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0025523
22 abnormal tricuspid chordae tendinae morphology 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0031442
23 pericarditis 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001701
24 aortic valve stenosis 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001650
25 aortic regurgitation 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001659
26 abnormal heart valve morphology 58 Frequent (79-30%)
27 arrhythmia 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Loeffler Endocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.02 IL3 IL5 PDGFRA PRG2 THBD

Drugs & Therapeutics for Loeffler Endocarditis

Search Clinical Trials, NIH Clinical Center for Loeffler Endocarditis

Genetic Tests for Loeffler Endocarditis

Anatomical Context for Loeffler Endocarditis

Organs/tissues related to Loeffler Endocarditis:

MalaCards : Heart, Thyroid, Lung, Liver

Publications for Loeffler Endocarditis

Articles related to Loeffler Endocarditis:

(show top 50) (show all 113)
# Title Authors PMID Year
1
Case 305: Loeffler Endocarditis. 62
35994399 2022
2
Loeffler Endocarditis Causing Heart Failure with Preserved Ejection Fraction (HFpEF): Characteristic Images and Diagnostic Pathway. 62
36140558 2022
3
Multimodality imaging of eosinophilic endocarditis with intracardiac right ventricular thrombus. 62
35900252 2022
4
Hypereosinophilic Syndrome with Advanced-Stage Loeffler Endocarditis. 62
35818495 2022
5
Mixed-Etiology Restrictive Cardiomyopathy (Desminopathy and Hemochromatosis) with Complex Liver Lesions. 62
35456383 2022
6
Loeffler endocarditis with intracardiac thrombus: case report and literature review. 62
34961478 2021
7
A case of hypereosinophilic syndrome with Loeffler endocarditis successfully bridged to heart transplantation by biventricular mechanical support. 62
33501681 2021
8
Normalization of left ventricular filling pressure after cardiac surgery for the Loeffler's endocarditis: a case report. 62
34263118 2021
9
Follow-up CMR in a case of Loeffler endocarditis. 62
33489229 2021
10
Loeffler Endocarditis as a Manifestation of Paraneoplastic Hypereosinophilia. 62
33117933 2020
11
Loeffler Endocarditis and Associated Parasitosis: A Diagnostic Challenge. 62
32550071 2020
12
Loeffler Endocarditis: A Manifestation of Hypereosinophilic Syndrome. 62
32337394 2020
13
Loeffler Endocarditis in Idiopathic Hypereosinophilic Syndrome Demonstrated by Magnetic Resonance Imaging Effectively Treated by Corticosteroids. 62
31571804 2019
14
Morphologically proved ANCA positive Loeffler's pancarditis: medical and surgical treatment. 62
31094483 2019
15
Loeffler's endocarditis with isolated left ventricular involvement on cardiac MRI. 62
31005861 2019
16
Loeffler Endocarditis: A Diagnosis Made with Cardiovascular Magnetic Resonance. 62
30701721 2019
17
Loeffler endocarditis associated with a massive right intraventricular thrombus. 62
30006896 2018
18
Successful Medical Management of a Rare Loeffler Endocarditis Case. 62
29968439 2018
19
Loeffler endocarditis in chronic eosinophilic leukemia with FIP1L1/PDGFRA rearrangement: full recovery with low dose imatinib. 62
28651427 2018
20
Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature. 62
29538200 2018
21
A Case of Loeffler Endocarditis That Showed Endomyocardial Systolic Dysfunction Detected by Layer Specific Strain Analysis. 62
29151479 2017
22
Cardiac involvements in hypereosinophilia-associated syndrome: Case reports and a little review of the literature. 62
28573678 2017
23
Usefulness of three-dimensional echocardiography in the assessment of valvular involvement in Loeffler endocarditis. 62
28600838 2017
24
Eosinophilic endomyocardial disease. 62
28157661 2017
25
When Hypereosinophilia Leads to Stroke. 62
30755950 2017
26
Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. 62
28890659 2017
27
Loeffler endocarditis in young woman - a case report. 62
27883350 2016
28
ANCA-negative eosinophilic granulomatosis with polyangitis (EGPA) manifesting as a large intracardiac thrombus and glomerulonephritis with angionecrosis. 62
27591039 2016
29
Loeffler endocarditis: silent right ventricular myocardium! 62
26980214 2016
30
Development of eosinophilic endomyocardial disease in a patient with episodic angioedema and eosinophilia. 62
26563671 2016
31
Echocardiographic Changes in Eosinophilic Endocarditis Induced by Churg-Strauss Syndrome. 62
27725542 2016
32
Loeffler endocarditis in a patient with non-Hodgkin's lymphoma. 62
27004546 2016
33
Hematological dyspnea: A rare cause with gratifying recovery. 62
30671146 2015
34
Restrictive myocardium with an unusual pattern of apical hypertrophic cardiomyopathy. 62
25804825 2015
35
Cutaneous B-lymphoblastic lymphoma with IL3/IgH translocation presenting with hypereosinophilia and acute endocarditis. 62
25382309 2015
36
Biopsy-proven Loeffler endocarditis successfully treated with steroids. 62
25712061 2015
37
Severe mitral regurgitation caused by eosinophilic endocarditis. 62
30546520 2014
38
Three-dimensional speckle-tracking echocardiography in Loeffler endocarditis: case report from the MAGYAR-Path Study. 62
23846825 2014
39
Confirmation of diagnosis and graduation of inflammatory activity of Loeffler endocarditis by hybrid positron emission tomography/magnetic resonance imaging. 62
24713639 2014
40
Loeffler endocarditis in a pediatric patient. 62
23802753 2014
41
Myeloproliferative hypereosinophilic syndrome presenting as cardiac failure and response to imatinib. 62
24603276 2014
42
Loeffler endocarditis of the left ventricle: cardiac magnetic resonance findings. 62
23706937 2013
43
Eosinophilic endocarditis and Strongyloides stercoralis. 62
23672985 2013
44
Crohn's disease and nontropical endomyocardial fibrosis. 62
23839293 2013
45
[Loeffler's endocarditis--a case report]. 62
22608505 2012
46
Gadolinium-enhanced cardiovascular magnetic resonance for the detection and characterization of Loeffler endocarditis in patients with hypereosinophilic syndrome. 62
21963210 2011
47
Eosinophil granule protein localization in eosinophilic endomyocardial disease. 62
21751935 2011
48
A case of systemic lupus erythematosus presenting with hypereosinophilia and Loeffler endocarditis. 62
21125980 2010
49
Magnetic resonance imaging of a hypereosinophilic endocarditis with apical thrombotic obliteration in Churg-Strauss syndrome complicated with acute abdominal aortic embolic occlusion. 62
19167111 2010
50
Loeffler endocarditis: magnetic resonance imaging features of pre- and post-operation. 62
20819614 2010

Variations for Loeffler Endocarditis

Expression for Loeffler Endocarditis

Search GEO for disease gene expression data for Loeffler Endocarditis.

Pathways for Loeffler Endocarditis

GO Terms for Loeffler Endocarditis

Biological processes related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA catabolic process GO:0006401 9.71 RNASE3 RNASE2
2 RNA phosphodiester bond hydrolysis GO:0090501 9.67 RNASE3 RNASE2
3 chemotaxis GO:0006935 9.65 RNASE3 RNASE2 PDGFRA
4 innate immune response in mucosa GO:0002227 9.62 RNASE3 RNASE2
5 negative regulation of platelet activation GO:0010544 9.26 THBD PDGFRA
6 RNA metabolic process GO:0016070 9.16 RNASE3 RNASE2
7 induction of bacterial agglutination GO:0043152 8.8 RNASE3 RNASE2

Molecular functions related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ribonuclease activity GO:0004540 8.92 RNASE3 RNASE2

Sources for Loeffler Endocarditis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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