MCID: LFF001
MIFTS: 26

Loeffler Endocarditis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Loeffler Endocarditis

MalaCards integrated aliases for Loeffler Endocarditis:

Name: Loeffler Endocarditis 12 59 15
Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy 73
Eosinophilic Endomyocardial Disease 12
Eosinophilic Endocarditis 59
Loeffler's Endocarditis 73

Characteristics:

Orphanet epidemiological data:

59
loeffler endocarditis
Age of onset: Adolescent,Adult,Childhood;

Classifications:



External Ids:

Disease Ontology 12 DOID:396
ICD10 33 I42.3
NCIt 50 C27044
SNOMED-CT 68 33258008
Orphanet 59 ORPHA75566
UMLS via Orphanet 74 C0206143
ICD10 via Orphanet 34 I42.3

Summaries for Loeffler Endocarditis

Disease Ontology : 12 A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils.

MalaCards based summary : Loeffler Endocarditis, also known as primary eosinophilic endomyocardial restrictive cardiomyopathy, is related to endomyocardial fibrosis and chronic eosinophilic leukemia. An important gene associated with Loeffler Endocarditis is FIP1L1 (Factor Interacting With PAPOLA And CPSF1), and among its related pathways/superpathways is Allograft rejection. Affiliated tissues include heart.

Wikipedia : 76 Loeffler endocarditis is a form of restrictive cardiomyopathy caused by infiltration of the heart by... more...

Related Diseases for Loeffler Endocarditis

Diseases related to Loeffler Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 endomyocardial fibrosis 30.1 FIP1L1 PDGFRA
2 chronic eosinophilic leukemia 30.1 FIP1L1 PDGFRA
3 primary hypereosinophilic syndrome 28.7 ETV6 FIP1L1 PDGFRA
4 hypereosinophilic syndrome 28.5 FIP1L1 IL5 PDGFRA RNASE3
5 endocarditis 10.6
6 cough variant asthma 10.3 IL5 RNASE3
7 inflammatory bowel disease 4 10.3 IL5 RNASE3
8 cow milk allergy 10.3 IL5 RNASE3
9 paragonimiasis 10.2 IL5 RNASE3
10 intrinsic asthma 10.2 IL5 RNASE3
11 atopic keratoconjunctivitis 10.2 IL5 RNASE3
12 eosinophilic gastroenteritis 10.2 IL5 RNASE3
13 chronic eosinophilic pneumonia 10.2 IL5 RNASE3
14 latex allergy 10.2 IL5 RNASE3
15 gastrointestinal allergy 10.2 IL5 RNASE3
16 urinary schistosomiasis 10.2 IL5 RNASE3
17 chronic conjunctivitis 10.2 IL5 RNASE3
18 status asthmaticus 10.2 IL5 RNASE3
19 pdgfra-associated chronic eosinophilic leukemia 10.2 FIP1L1 PDGFRA
20 kimura disease 10.2 IL5 RNASE3
21 sm-ahnmd 10.2 FIP1L1 PDGFRA
22 vernal keratoconjunctivitis 10.2 IL5 RNASE3
23 cellulitis 10.2 IL5 RNASE3
24 sinusitis 10.2 IL5 RNASE3
25 pollen allergy 10.2 IL5 RNASE3
26 conjunctival disease 10.2 IL5 RNASE3
27 milk allergy 10.2 IL5 RNASE3
28 wells syndrome 10.2 IL5 RNASE3
29 churg-strauss syndrome 10.2 IL5 RNASE3
30 pulmonary eosinophilia 10.2 IL5 RNASE3
31 eosinophilic pneumonia 10.2 IL5 RNASE3
32 corneal dystrophy, subepithelial mucinous 10.2 FIP1L1 PDGFRA
33 onchocerciasis 10.2 IL5 RNASE3
34 allergic conjunctivitis 10.2 IL5 RNASE3
35 nasal cavity disease 10.2 IL5 RNASE3
36 nose disease 10.2 IL5 RNASE3
37 common cold 10.1 IL5 RNASE3
38 parasitic helminthiasis infectious disease 10.1 IL5 RNASE3
39 upper respiratory tract disease 10.1 IL5 RNASE3
40 conjunctivitis 10.1 IL5 RNASE3
41 keratoconjunctivitis 10.1 IL5 RNASE3
42 systemic mastocytosis 10.1 FIP1L1 PDGFRA
43 food allergy 10.1 IL5 RNASE3
44 gastroenteritis 10.1 IL5 RNASE3
45 bronchial disease 10.1 IL5 RNASE3
46 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 IL5 RNASE3
47 budd-chiari syndrome 10.1 FIP1L1 PDGFRA
48 ige responsiveness, atopic 10.0 IL5 RNASE3
49 myeloproliferative neoplasm 10.0 FIP1L1 PDGFRA
50 schistosomiasis 10.0 IL5 RNASE3

Graphical network of the top 20 diseases related to Loeffler Endocarditis:



Diseases related to Loeffler Endocarditis

Symptoms & Phenotypes for Loeffler Endocarditis

Drugs & Therapeutics for Loeffler Endocarditis

Search Clinical Trials , NIH Clinical Center for Loeffler Endocarditis

Genetic Tests for Loeffler Endocarditis

Anatomical Context for Loeffler Endocarditis

MalaCards organs/tissues related to Loeffler Endocarditis:

41
Heart

Publications for Loeffler Endocarditis

Articles related to Loeffler Endocarditis:

(show all 25)
# Title Authors Year
1
Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature. ( 29538200 )
2018
2
Successful Medical Management of a Rare Loeffler Endocarditis Case. ( 29968439 )
2018
3
Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. ( 28890659 )
2017
4
Usefulness of three-dimensional echocardiography in the assessment of valvular involvement in Loeffler endocarditis. ( 28600838 )
2017
5
A Case of Loeffler Endocarditis That Showed Endomyocardial Systolic Dysfunction Detected by Layer Specific Strain Analysis. ( 29151479 )
2017
6
Loeffler endocarditis in chronic eosinophilic leukemia with FIP1L1/PDGFRA rearrangement: full recovery with low dose imatinib. ( 28651427 )
2017
7
Loeffler endocarditis in a patient with non-Hodgkin's lymphoma. ( 27004546 )
2016
8
Loeffler endocarditis in young woman - a case report. ( 27883350 )
2016
9
Loeffler endocarditis: silent right ventricular myocardium! ( 26980214 )
2016
10
Biopsy-proven Loeffler endocarditis successfully treated with steroids. ( 25712061 )
2015
11
Confirmation of diagnosis and graduation of inflammatory activity of Loeffler endocarditis by hybrid positron emission tomography/magnetic resonance imaging. ( 24713639 )
2014
12
Loeffler endocarditis of the left ventricle: cardiac magnetic resonance findings. ( 23706937 )
2013
13
Three-dimensional speckle-tracking echocardiography in Loeffler endocarditis : Case report from the MAGYAR-Path Study. ( 23846825 )
2013
14
Loeffler Endocarditis in a Pediatric Patient. ( 23802753 )
2013
15
Gadolinium-enhanced cardiovascular magnetic resonance for the detection and characterization of Loeffler endocarditis in patients with hypereosinophilic syndrome. ( 21963210 )
2011
16
Loeffler endocarditis: magnetic resonance imaging features of pre- and post-operation. ( 20819614 )
2010
17
A case of systemic lupus erythematosus presenting with hypereosinophilia and Loeffler endocarditis. ( 21125980 )
2010
18
Loeffler endocarditis: findings on magnetic resonance imaging. ( 21687129 )
2009
19
Idiopathic hypereosinophilia syndrome with loeffler endocarditis, embolic cerebral infarction, and left hydranencephaly: a case report. ( 19960966 )
2009
20
A child with eosinophilia, Loeffler endocarditis, and acute lymphoblastic leukemia. ( 19123015 )
2009
21
Images in cardiovascular medicine. Loeffler endocarditis mimicking apical hypertrophic cardiomyopathy. ( 19581522 )
2009
22
Loeffler endocarditis: findings on magnetic resonance imaging. ( 17322509 )
2007
23
Loeffler endocarditis: what have we learned? ( 17573694 )
2007
24
Pathologic quiz case: a young woman with eosinophilia and heart failure. Primary hypereosinophilic syndrome with loeffler endocarditis. ( 15628926 )
2005
25
Ventricular remodeling in Loeffler endocarditis: implications for therapeutic decision making. ( 16188499 )
2005

Variations for Loeffler Endocarditis

Expression for Loeffler Endocarditis

Search GEO for disease gene expression data for Loeffler Endocarditis.

Pathways for Loeffler Endocarditis

Pathways related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.54 IL5 PDGFRA RNASE3

GO Terms for Loeffler Endocarditis

Molecular functions related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.62 IL5 PDGFRA

Sources for Loeffler Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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