Loeffler Endocarditis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LFF001 MIFTS: 30	Loeffler Endocarditis Categories: Blood diseases, Cardiovascular diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Loeffler Endocarditis

MalaCards integrated aliases for Loeffler Endocarditis:

Name: Loeffler Endocarditis ¹² ⁵⁸ ¹⁵

Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy ⁷¹

Eosinophilic Endomyocardial Disease ¹²

Eosinophilic Endocarditis ⁵⁸

Loeffler's Endocarditis ⁷¹

Characteristics:

Orphanet epidemiological data:

⁵⁸

loeffler endocarditis
Age of onset: Adolescent,Adult,Childhood;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³² ³³

Diseases of the circulatory system

Other forms of heart disease

Cardiomyopathy

Endomyocardial (eosinophilic) disease

External Ids:

Disease Ontology ¹² DOID:396

NCIt ⁴⁹ C27044

SNOMED-CT ⁶⁷ 33258008

ICD10 ³² I42.3

ICD10 via Orphanet ³³ I42.3

UMLS via Orphanet ⁷² C0206143

Orphanet ⁵⁸ ORPHA75566

UMLS ⁷¹ C0206143 C0264834

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Summaries for Loeffler Endocarditis

Disease Ontology : ¹² A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils.

MalaCards based summary : Loeffler Endocarditis, also known as primary eosinophilic endomyocardial restrictive cardiomyopathy, is related to pdgfra-associated chronic eosinophilic leukemia and primary hypereosinophilic syndrome. An important gene associated with Loeffler Endocarditis is FIP1L1 (Factor Interacting With PAPOLA And CPSF1), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. Affiliated tissues include heart, myeloid and b lymphoblasts.

Wikipedia : ⁷⁴ Loeffler endocarditis is a form of heart disease characterized by a stiffened, poorly-functioning heart... more...

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Related Diseases for Loeffler Endocarditis

Diseases related to Loeffler Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)

#	Related Disease	Score	Top Affiliating Genes
1	pdgfra-associated chronic eosinophilic leukemia	32.5	PDGFRA FIP1L1
2	primary hypereosinophilic syndrome	30.5	PDGFRA FIP1L1
3	chronic eosinophilic leukemia	29.8	PDGFRA IL5 FIP1L1
4	hypereosinophilic syndrome, idiopathic	28.9	PDGFRA IL5 IL3 FIP1L1
5	hypereosinophilic syndrome	28.8	RNASE3 PRG2 PDGFRA IL5 IL3 FIP1L1
6	churg-strauss syndrome	28.7	RNASE3 PRG2 IL5 IL3
7	endomyocardial fibrosis	28.6	RNASE3 RNASE2 PRG2 PDGFRA IL5 FIP1L1
8	endocarditis	10.9
9	restrictive cardiomyopathy	10.4
10	mitral valve insufficiency	10.3
11	congestive heart failure	10.3
12	eosinophilic colitis	10.2	RNASE3 PRG2
13	sm-ahnmd	10.2	PDGFRA FIP1L1
14	myeloid and lymphoid neoplasms associated with pdgfra rearrangement	10.2	PDGFRA FIP1L1
15	ocular cicatricial pemphigoid	10.2	RNASE3 PRG2
16	giant papillary conjunctivitis	10.2	RNASE3 PRG2
17	aggressive systemic mastocytosis	10.1	PDGFRA FIP1L1
18	systemic mastocytosis	10.1	PDGFRA FIP1L1
19	atrial standstill 1	10.1
20	fibrosis of extraocular muscles, congenital, 1	10.1
21	systemic lupus erythematosus	10.1
22	leukemia, acute lymphoblastic	10.1
23	lymphoma	10.1
24	lymphocytic leukemia	10.1
25	heart disease	10.1
26	leukemia	10.1
27	antiphospholipid syndrome	10.1
28	hydranencephaly	10.1
29	lupus erythematosus	10.1
30	diastolic heart failure	10.1
31	hypertrophic cardiomyopathy	10.1
32	conjunctivitis	10.1	RNASE3 IL5
33	cough variant asthma	10.0	RNASE3 IL5
34	pemphigoid gestationis	10.0	RNASE3 IL5
35	vernal keratoconjunctivitis	10.0	RNASE3 IL5
36	paragonimiasis	10.0	RNASE3 IL5
37	wells syndrome	10.0	RNASE3 IL5
38	elephantiasis	10.0	RNASE3 IL5
39	chronic rhinitis	10.0	RNASE3 IL5
40	chronic leukemia	10.0	PDGFRA FIP1L1
41	chronic conjunctivitis	10.0	RNASE3 IL5
42	cow milk allergy	10.0	RNASE3 IL5
43	milk allergy	10.0	RNASE3 IL5
44	kimura disease	10.0	RNASE3 IL5
45	chronic eosinophilic pneumonia	10.0	RNASE3 IL5
46	granulomatosis with polyangiitis	10.0
47	cyanosis, transient neonatal	10.0
48	sarcoma	10.0
49	angioedema	10.0
50	tricuspid valve insufficiency	10.0

Graphical network of the top 20 diseases related to Loeffler Endocarditis:

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Symptoms & Phenotypes for Loeffler Endocarditis

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Drugs & Therapeutics for Loeffler Endocarditis

Search Clinical Trials , NIH Clinical Center for Loeffler Endocarditis

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Genetic Tests for Loeffler Endocarditis

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Anatomical Context for Loeffler Endocarditis

MalaCards organs/tissues related to Loeffler Endocarditis:

⁴⁰

Heart, Myeloid, B Lymphoblasts

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Publications for Loeffler Endocarditis

Articles related to Loeffler Endocarditis:

(show all 43)

#	Title	Authors	PMID	Year
1	Loeffler Endocarditis in Idiopathic Hypereosinophilic Syndrome Demonstrated by Magnetic Resonance Imaging Effectively Treated by Corticosteroids. ⁶¹	Zhou Y...Ge J	31571804	2019
2	Morphologically proved ANCA positive Loeffler's pancarditis: medical and surgical treatment. ⁶¹	Blagova OV...Fomin VV	31094483	2019
3	Loeffler's endocarditis with isolated left ventricular involvement on cardiac MRI. ⁶¹	Kumar P...Malhi AS	31005861	2019
4	Loeffler Endocarditis: A Diagnosis Made with Cardiovascular Magnetic Resonance. ⁶¹	Kalra DK...Goldberg A	30701721	2019
5	Loeffler endocarditis associated with a massive right intraventricular thrombus. ⁶¹	Muniz MT...Garcia J	30006896	2018
6	Successful Medical Management of a Rare Loeffler Endocarditis Case. ⁶¹	Gulel O...Elmali M	29968439	2018
7	Loeffler endocarditis in chronic eosinophilic leukemia with FIP1L1/PDGFRA rearrangement: full recovery with low dose imatinib. ⁶¹	Kim DS...Choi CW	28651427	2018
8	Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature. ⁶¹	Gao M...Zheng Y	29538200	2018
9	A Case of Loeffler Endocarditis That Showed Endomyocardial Systolic Dysfunction Detected by Layer Specific Strain Analysis. ⁶¹	Jin X...Yang J	29151479	2017
10	Cardiac involvements in hypereosinophilia-associated syndrome: Case reports and a little review of the literature. ⁶¹	Jin X...Yang J	28573678	2017
11	Usefulness of three-dimensional echocardiography in the assessment of valvular involvement in Loeffler endocarditis. ⁶¹	Hernandez CM...Gallardo SM	28600838	2017
12	When Hypereosinophilia Leads to Stroke. ⁶¹	Chalayer E...Tardy B	30755950	2017
13	Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. ⁶¹	Alam A...Jermyn R	28890659	2017
14	Loeffler endocarditis in young woman - a case report. ⁶¹	Osovska NY...Knyazkova II	27883350	2016
15	ANCA-negative eosinophilic granulomatosis with polyangitis (EGPA) manifesting as a large intracardiac thrombus and glomerulonephritis with angionecrosis. ⁶¹	Saito Y...Kobayashi Y	27591039	2016
16	Loeffler endocarditis: silent right ventricular myocardium! ⁶¹	Cetin S...Hazirolan T	26980214	2016
17	Loeffler endocarditis in a patient with non-Hodgkin's lymphoma. ⁶¹	Aguiar Rosa S...Cruz Ferreira R	27004546	2016
18	Hematological dyspnea: A rare cause with gratifying recovery. ⁶¹	Gupta A...Nanjappa MC	30671146	2015
19	Restrictive myocardium with an unusual pattern of apical hypertrophic cardiomyopathy. ⁶¹	Sato T...Nakatani T	25804825	2015
20	Cutaneous B-lymphoblastic lymphoma with IL3/IgH translocation presenting with hypereosinophilia and acute endocarditis. ⁶¹	Bomken S...Windebank K	25382309	2015
21	Biopsy-proven Loeffler endocarditis successfully treated with steroids. ⁶¹	Inoue T...Kawai C	25712061	2015
22	Three-dimensional speckle-tracking echocardiography in Loeffler endocarditis: case report from the MAGYAR-Path Study. ⁶¹	Nemes A...Forster T	23846825	2014
23	Confirmation of diagnosis and graduation of inflammatory activity of Loeffler endocarditis by hybrid positron emission tomography/magnetic resonance imaging. ⁶¹	Langwieser N...Ibrahim T	24713639	2014
24	Loeffler endocarditis in a pediatric patient. ⁶¹	Keivanidou A...Athanasiadou F	23802753	2014
25	Loeffler endocarditis of the left ventricle: cardiac magnetic resonance findings. ⁶¹	Bonanad C...Lopez-Lereu MP	23706937	2013
26	Crohn's disease and nontropical endomyocardial fibrosis. ⁶¹	Ennezat PV...Vincentelli A	23839293	2013
27	Gadolinium-enhanced cardiovascular magnetic resonance for the detection and characterization of Loeffler endocarditis in patients with hypereosinophilic syndrome. ⁶¹	Ibrahim T...Schomig A	21963210	2011
28	A case of systemic lupus erythematosus presenting with hypereosinophilia and Loeffler endocarditis. ⁶¹	Aydogdu S...Cetin M	21125980	2010
29	Loeffler endocarditis: magnetic resonance imaging features of pre- and post-operation. ⁶¹	Fan ZM...Zhang ZQ	20819614	2010
30	Idiopathic hypereosinophilia syndrome with loeffler endocarditis, embolic cerebral infarction, and left hydranencephaly: a case report. ⁶¹	Lin CH...Chang CC	19960966	2009
31	[Hypereosinophilic syndrome (Loeffler endocarditis)]. ⁶¹	Kandemir C...Bildirici IH	19875916	2009
32	Images in cardiovascular medicine. Loeffler endocarditis mimicking apical hypertrophic cardiomyopathy. ⁶¹	Chang SA...Sohn DW	19581522	2009
33	A child with eosinophilia, Loeffler endocarditis, and acute lymphoblastic leukemia. ⁶¹	Files MD...Langley SM	19123015	2009
34	Loeffler endocarditis: findings on magnetic resonance imaging. ⁶¹	Schreiber K...Gawaz M	21687129	2009
35	Mitral valve destruction by Hodgkin's lymphoma-associated Loefler endocarditis. ⁶¹	Yalonetsky S...Lorber A	18004615	2008
36	Loeffler endocarditis: what have we learned? ⁶¹	Benezet-Mazuecos J...Farre J	17573694	2007
37	Loeffler endocarditis: findings on magnetic resonance imaging. ⁶¹	Schreiber K...Gawaz M	17322509	2007
38	Ventricular remodeling in Loeffler endocarditis: implications for therapeutic decision making. ⁶¹	Lofiego C...Rapezzi C	16188499	2005
39	Left ventricular endocardial calcification in a patient with myeloproliferative disease. ⁶¹	Khouzam RN...D'Cruz IA	16217993	2005
40	Pathologic quiz case: a young woman with eosinophilia and heart failure. Primary hypereosinophilic syndrome with loeffler endocarditis. ⁶¹	Cunningham K...Veinot JP	15628926	2005
41	Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature. ⁶¹	Keung YK...Pettnati M	12505259	2002
42	[Restrictive cardiomyopathies]. ⁶¹	Rapezzi C...Magnani B	8020028	1993
43	[Fibrous hypereosinophilic parietal endocarditis (Loeffler Endocarditis)]. ⁶¹	GERBAUX A...LENEGRE J	13342946	1956

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Genes for Loeffler Endocarditis

Genes related to Loeffler Endocarditis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	6.95	DISEASES inferred ¹⁵
2	PRG2	Proteoglycan 2, Pro Eosinophil Major Basic Protein	Protein Coding	6.36	DISEASES inferred ¹⁵
3	RNASE3	Ribonuclease A Family Member 3	Protein Coding	6.36	DISEASES inferred ¹⁵
4	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	6.18	DISEASES inferred ¹⁵
5	RNASE2	Ribonuclease A Family Member 2	Protein Coding	5.22	DISEASES inferred ¹⁵
6	IL5	Interleukin 5	Protein Coding	4.91	DISEASES inferred ¹⁵
7	IL3	Interleukin 3	Protein Coding	4.75	DISEASES inferred ¹⁵
8	TNNI1	Troponin I1, Slow Skeletal Type	Protein Coding	4.43	DISEASES inferred ¹⁵

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Variations for Loeffler Endocarditis

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Expression for Loeffler Endocarditis

Search GEO for disease gene expression data for Loeffler Endocarditis.

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Pathways for Loeffler Endocarditis

Pathways related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.5	RNASE3 RNASE2 PRG2 PDGFRA IL5 IL3
2	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	11.76	RNASE3 PRG2 PDGFRA IL5 IL3
3	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	11.75	PDGFRA IL5 IL3
4	JAK-STAT signaling pathway (KEGG) ³⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴	11.7	PDGFRA IL5 IL3
5	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.28	IL5 IL3
6	Hematopoietic Stem Cell Differentiation ¹	11	IL5 IL3
7	Cytokines and Inflammatory Response ¹	10.72	IL5 IL3
8	G-protein signaling_Rap2B regulation pathway ²²	10.16	PRG2 PDGFRA IL5 IL3

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GO Terms for Loeffler Endocarditis

Biological processes related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MAPK cascade	GO:0000165	9.33	PDGFRA IL5 IL3
2	RNA phosphodiester bond hydrolysis	GO:0090501	9.26	RNASE3 RNASE2
3	RNA catabolic process	GO:0006401	8.96	RNASE3 RNASE2
4	induction of bacterial agglutination	GO:0043152	8.62	RNASE3 RNASE2

Molecular functions related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopolysaccharide binding	GO:0001530	8.96	RNASE3 RNASE2
2	ribonuclease activity	GO:0004540	8.62	RNASE3 RNASE2

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Sources for Loeffler Endocarditis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia