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MCID: LFF001
MIFTS: 30

Loeffler Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Loeffler Endocarditis

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MalaCards integrated aliases for Loeffler Endocarditis:

Name: Loeffler Endocarditis 12 58 15
Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy 71
Eosinophilic Endomyocardial Disease 12
Eosinophilic Endocarditis 58
Loeffler's Endocarditis 71

Characteristics:

Orphanet epidemiological data:

58
loeffler endocarditis
Age of onset: Adolescent,Adult,Childhood;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32 33


External Ids:

Disease Ontology 12 DOID:396
NCIt 49 C27044
SNOMED-CT 67 33258008
ICD10 32 I42.3
ICD10 via Orphanet 33 I42.3
UMLS via Orphanet 72 C0206143
Orphanet 58 ORPHA75566
UMLS 71 C0206143 C0264834
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Summaries for Loeffler Endocarditis

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Disease Ontology : 12 A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils.

MalaCards based summary : Loeffler Endocarditis, also known as primary eosinophilic endomyocardial restrictive cardiomyopathy, is related to pdgfra-associated chronic eosinophilic leukemia and primary hypereosinophilic syndrome. An important gene associated with Loeffler Endocarditis is FIP1L1 (Factor Interacting With PAPOLA And CPSF1), and among its related pathways/superpathways are Innate Immune System and JAK-STAT signaling pathway. Affiliated tissues include heart and b lymphoblasts.

Wikipedia : 74 Loeffler endocarditis is a form of heart disease characterized by a stiffened, poorly-functioning heart... more...

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Related Diseases for Loeffler Endocarditis

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Diseases related to Loeffler Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 pdgfra-associated chronic eosinophilic leukemia 32.5 PDGFRA FIP1L1
2 primary hypereosinophilic syndrome 30.0 PDGFRA FIP1L1 ETV6
3 chronic eosinophilic leukemia 29.2 PDGFRA IL5 FIP1L1 ETV6
4 hypereosinophilic syndrome 28.9 RNASE3 PRG2 PDGFRA IL5 IL3 FIP1L1
5 hypereosinophilic syndrome, idiopathic 28.9 PDGFRA IL5 IL3 FIP1L1
6 churg-strauss syndrome 28.7 RNASE3 PRG2 IL5 IL3
7 endomyocardial fibrosis 28.6 RNASE3 RNASE2 PRG2 PDGFRA IL5 FIP1L1
8 endocarditis 10.9
9 restrictive cardiomyopathy 10.5
10 mitral valve insufficiency 10.3
11 congestive heart failure 10.3
12 eosinophilic colitis 10.2 RNASE3 PRG2
13 sm-ahnmd 10.2 PDGFRA FIP1L1
14 ocular cicatricial pemphigoid 10.2 RNASE3 PRG2
15 giant papillary conjunctivitis 10.2 RNASE3 PRG2
16 myeloproliferative disorder, chronic, with eosinophilia 10.2 FIP1L1 ETV6
17 atrial standstill 1 10.1
18 systemic lupus erythematosus 10.1
19 leukemia, acute lymphoblastic 10.1
20 lymphoma 10.1
21 heart disease 10.1
22 hypertrophic cardiomyopathy 10.1
23 leukemia 10.1
24 antiphospholipid syndrome 10.1
25 hydranencephaly 10.1
26 lupus erythematosus 10.1
27 diastolic heart failure 10.1
28 loeffler syndrome 10.1 IL5 FIP1L1
29 cerebellar angioblastoma 10.1 PDGFRA ETV6
30 cough variant asthma 10.0 RNASE3 IL5
31 vernal keratoconjunctivitis 10.0 RNASE3 IL5
32 pemphigoid gestationis 10.0 RNASE3 IL5
33 vasomotor rhinitis 10.0 RNASE3 IL5
34 paragonimiasis 10.0 RNASE3 IL5
35 elephantiasis 10.0 RNASE3 IL5
36 wells syndrome 10.0 RNASE3 IL5
37 chronic rhinitis 10.0 RNASE3 IL5
38 cow milk allergy 10.0 RNASE3 IL5
39 milk allergy 10.0 RNASE3 IL5
40 kimura disease 10.0 RNASE3 IL5
41 aggressive systemic mastocytosis 10.0 PDGFRA FIP1L1
42 chronic conjunctivitis 10.0 RNASE3 IL5
43 chronic eosinophilic pneumonia 10.0 RNASE3 IL5
44 latex allergy 10.0 RNASE3 IL5
45 urinary schistosomiasis 10.0 RNASE3 IL5
46 systemic mastocytosis 10.0 PDGFRA FIP1L1
47 atypical chronic myeloid leukemia 10.0 PDGFRA ETV6
48 status asthmaticus 10.0 RNASE3 IL5
49 ige responsiveness, atopic 10.0 RNASE3 IL5
50 chronic leukemia 10.0 PDGFRA FIP1L1

Graphical network of the top 20 diseases related to Loeffler Endocarditis:



Diseases related to Loeffler Endocarditis
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Symptoms & Phenotypes for Loeffler Endocarditis

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Drugs & Therapeutics for Loeffler Endocarditis

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Search Clinical Trials , NIH Clinical Center for Loeffler Endocarditis

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Genetic Tests for Loeffler Endocarditis

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Anatomical Context for Loeffler Endocarditis

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MalaCards organs/tissues related to Loeffler Endocarditis:

40
Heart, B Lymphoblasts
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Publications for Loeffler Endocarditis

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Articles related to Loeffler Endocarditis:

(show all 45)
# Title Authors PMID Year
1
Loeffler Endocarditis and Associated Parasitosis: A Diagnostic Challenge. 61
32550071 2020
2
Loeffler Endocarditis: A Manifestation of Hypereosinophilic Syndrome. 61
32337394 2020
3
Loeffler Endocarditis in Idiopathic Hypereosinophilic Syndrome Demonstrated by Magnetic Resonance Imaging Effectively Treated by Corticosteroids. 61
31571804 2019
4
Morphologically proved ANCA positive Loeffler's pancarditis: medical and surgical treatment. 61
31094483 2019
5
Loeffler's endocarditis with isolated left ventricular involvement on cardiac MRI. 61
31005861 2019
6
Loeffler Endocarditis: A Diagnosis Made with Cardiovascular Magnetic Resonance. 61
30701721 2019
7
Loeffler endocarditis associated with a massive right intraventricular thrombus. 61
30006896 2018
8
Successful Medical Management of a Rare Loeffler Endocarditis Case. 61
29968439 2018
9
Loeffler endocarditis in chronic eosinophilic leukemia with FIP1L1/PDGFRA rearrangement: full recovery with low dose imatinib. 61
28651427 2018
10
Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature. 61
29538200 2018
11
A Case of Loeffler Endocarditis That Showed Endomyocardial Systolic Dysfunction Detected by Layer Specific Strain Analysis. 61
29151479 2017
12
Cardiac involvements in hypereosinophilia-associated syndrome: Case reports and a little review of the literature. 61
28573678 2017
13
Usefulness of three-dimensional echocardiography in the assessment of valvular involvement in Loeffler endocarditis. 61
28600838 2017
14
Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. 61
28890659 2017
15
When Hypereosinophilia Leads to Stroke. 61
30755950 2017
16
Loeffler endocarditis in young woman - a case report. 61
27883350 2016
17
ANCA-negative eosinophilic granulomatosis with polyangitis (EGPA) manifesting as a large intracardiac thrombus and glomerulonephritis with angionecrosis. 61
27591039 2016
18
Loeffler endocarditis: silent right ventricular myocardium! 61
26980214 2016
19
Loeffler endocarditis in a patient with non-Hodgkin's lymphoma. 61
27004546 2016
20
Hematological dyspnea: A rare cause with gratifying recovery. 61
30671146 2015
21
Restrictive myocardium with an unusual pattern of apical hypertrophic cardiomyopathy. 61
25804825 2015
22
Cutaneous B-lymphoblastic lymphoma with IL3/IgH translocation presenting with hypereosinophilia and acute endocarditis. 61
25382309 2015
23
Biopsy-proven Loeffler endocarditis successfully treated with steroids. 61
25712061 2015
24
Three-dimensional speckle-tracking echocardiography in Loeffler endocarditis: case report from the MAGYAR-Path Study. 61
23846825 2014
25
Confirmation of diagnosis and graduation of inflammatory activity of Loeffler endocarditis by hybrid positron emission tomography/magnetic resonance imaging. 61
24713639 2014
26
Loeffler endocarditis in a pediatric patient. 61
23802753 2014
27
Loeffler endocarditis of the left ventricle: cardiac magnetic resonance findings. 61
23706937 2013
28
Crohn's disease and nontropical endomyocardial fibrosis. 61
23839293 2013
29
Gadolinium-enhanced cardiovascular magnetic resonance for the detection and characterization of Loeffler endocarditis in patients with hypereosinophilic syndrome. 61
21963210 2011
30
A case of systemic lupus erythematosus presenting with hypereosinophilia and Loeffler endocarditis. 61
21125980 2010
31
Loeffler endocarditis: magnetic resonance imaging features of pre- and post-operation. 61
20819614 2010
32
Idiopathic hypereosinophilia syndrome with loeffler endocarditis, embolic cerebral infarction, and left hydranencephaly: a case report. 61
19960966 2009
33
Images in cardiovascular medicine. Loeffler endocarditis mimicking apical hypertrophic cardiomyopathy. 61
19581522 2009
34
[Hypereosinophilic syndrome (Loeffler endocarditis)]. 61
19875916 2009
35
A child with eosinophilia, Loeffler endocarditis, and acute lymphoblastic leukemia. 61
19123015 2009
36
Loeffler endocarditis: findings on magnetic resonance imaging. 61
21687129 2009
37
Mitral valve destruction by Hodgkin's lymphoma-associated Loefler endocarditis. 61
18004615 2008
38
Loeffler endocarditis: what have we learned? 61
17573694 2007
39
Loeffler endocarditis: findings on magnetic resonance imaging. 61
17322509 2007
40
Ventricular remodeling in Loeffler endocarditis: implications for therapeutic decision making. 61
16188499 2005
41
Left ventricular endocardial calcification in a patient with myeloproliferative disease. 61
16217993 2005
42
Pathologic quiz case: a young woman with eosinophilia and heart failure. Primary hypereosinophilic syndrome with loeffler endocarditis. 61
15628926 2005
43
Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature. 61
12505259 2002
44
[Restrictive cardiomyopathies]. 61
8020028 1993
45
[Fibrous hypereosinophilic parietal endocarditis (Loeffler Endocarditis)]. 61
13342946 1956
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Variations for Loeffler Endocarditis

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Expression for Loeffler Endocarditis

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Search GEO for disease gene expression data for Loeffler Endocarditis.
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Pathways for Loeffler Endocarditis

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Pathways related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.47 RNASE3 RNASE2 PRG2 PDGFRA IL5 IL3
2
JAK-STAT signaling pathway 36
Show member pathways
 11.94 PDGFRA IL5 IL3
3
Allograft rejection 1 36
Show member pathways
 11.76 RNASE3 PRG2 PDGFRA IL5 IL3
4
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.71 PDGFRA IL5 IL3
5
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.31 IL5 IL3
6
Hematopoietic Stem Cell Differentiation 1
10.94 IL5 IL3
7
Cytokines and Inflammatory Response 1
10.62 IL5 IL3
8
G-protein signaling_Rap2B regulation pathway 22
10.16 PRG2 PDGFRA IL5 IL3
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GO Terms for Loeffler Endocarditis

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Biological processes related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.33 PDGFRA IL5 IL3
2 RNA phosphodiester bond hydrolysis GO:0090501 9.26 RNASE3 RNASE2
3 RNA catabolic process GO:0006401 8.96 RNASE3 RNASE2
4 induction of bacterial agglutination GO:0043152 8.62 RNASE3 RNASE2

Molecular functions related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 RNASE3 RNASE2
2 ribonuclease activity GO:0004540 8.62 RNASE3 RNASE2
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Sources for Loeffler Endocarditis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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