Loeffler Endocarditis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ A rare restrictive cardiomyopathy characterized by hypereosinophilia and fibrous thickening of the endocardium, with usually large thrombi against the ventricle walls, that can lead to cardiovascular complications such as heart failure and thromboembolism. It manifests with symptoms like edema, fatigue and shortness of breath. It is usually secondary to eosinophil-associated tissue damage and is associated with idiopathic hypereosinophilic syndrome, chronic eosinophilic leukemia, carcinoma, or lymphoma.

MalaCards based summary: Loeffler Endocarditis, also known as primary eosinophilic endomyocardial restrictive cardiomyopathy, is related to primary hypereosinophilic syndrome and echinococcosis. An important gene associated with Loeffler Endocarditis is FIP1L1 (Factor Interacting With PAPOLA And CPSF1), and among its related pathways/superpathways are IL3-mediated signaling events and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Affiliated tissues include heart, thyroid and lung, and related phenotypes are eosinophilia and restrictive cardiomyopathy

Disease Ontology: ¹¹ A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils.

Wikipedia: ⁷⁵ Loeffler endocarditis is a form of heart disease characterized by a stiffened, poorly-functioning heart... more...

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Related Diseases for Loeffler Endocarditis

Diseases related to Loeffler Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)

#	Related Disease	Score	Top Affiliating Genes
1	primary hypereosinophilic syndrome	30.3	PDGFRA FIP1L1
2	echinococcosis	29.9	RNASE3 IL5
3	hypereosinophilic syndrome	29.9	RNASE3 PRG2 PDGFRA IL5 IL3 FIP1L1
4	mononeuritis multiplex	29.8	IL5 FIP1L1
5	granulomatosis with polyangiitis	29.8	RNASE3 IL5 FIP1L1
6	restrictive cardiomyopathy	29.6	TNNT2 RNASE3 RNASE2 PDGFRA FIP1L1
7	hypereosinophilic syndrome, idiopathic	29.5	PDGFRA IL5 IL3 FIP1L1
8	chronic eosinophilic leukemia	29.5	PDGFRA IL5 IL3 FIP1L1
9	endomyocardial fibrosis	29.1	RNASE3 RNASE2 PRG2 PDGFRA IL5 FIP1L1
10	churg-strauss syndrome	29.1	THBD RNASE3 PRG2 IL5 IL3
11	asthma	28.8	RNASE3 RNASE2 PRG2 IL5 IL3
12	pdgfra-associated chronic eosinophilic leukemia	11.2
13	endocarditis	10.8
14	myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1	10.2	PDGFRA FIP1L1
15	stress polycythemia	10.2	PDGFRA FIP1L1
16	heart disease	10.2
17	mitral valve insufficiency	10.2
18	sm-ahnmd	10.2	PDGFRA FIP1L1
19	myeloid and lymphoid neoplasms associated with pdgfra rearrangement	10.2	PDGFRA FIP1L1
20	indolent systemic mastocytosis	10.2	PDGFRA FIP1L1
21	systemic mastocytosis	10.2	PDGFRA FIP1L1
22	aggressive systemic mastocytosis	10.1	PDGFRA FIP1L1
23	persistent mild asthma	10.1	RNASE3 IL3
24	persistent severe asthma	10.1	RNASE3 IL5
25	thunderstorm triggered asthma	10.1	RNASE3 IL5
26	cough variant asthma	10.0	RNASE3 IL5
27	near-fatal asthma	10.0	RNASE3 IL5
28	aspirin-induced respiratory disease	10.0	RNASE3 IL5
29	kimura disease	10.0	RNASE3 IL5
30	chronic leukemia	10.0	PDGFRA FIP1L1
31	intermittent asthma	10.0	RNASE3 IL5
32	elephantiasis	10.0	RNASE3 IL5
33	vasomotor rhinitis	10.0	RNASE3 IL5
34	cardiac conduction defect	10.0
35	systemic lupus erythematosus	10.0
36	cardiomyopathy, familial hypertrophic, 1	10.0
37	lymphoma, hodgkin, classic	10.0
38	stroke, ischemic	10.0
39	systemic lupus erythematosus 1	10.0
40	leukemia, acute lymphoblastic	10.0
41	cysticercosis	10.0
42	filariasis	10.0
43	hypertrophic cardiomyopathy	10.0
44	alveolar echinococcosis	10.0
45	filarial elephantiasis	10.0
46	antiphospholipid syndrome	10.0
47	hydranencephaly	10.0
48	congestive heart failure	10.0
49	myocarditis	10.0
50	lupus erythematosus	10.0

Graphical network of the top 20 diseases related to Loeffler Endocarditis:

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Symptoms & Phenotypes for Loeffler Endocarditis

Human phenotypes related to Loeffler Endocarditis:

⁵⁸ ³⁰ (show all 27)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	eosinophilia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001880
2	restrictive cardiomyopathy ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001723
3	abnormal thrombosis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001977
4	myocardial eosinophilic infiltration ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0031323
5	fatigue ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012378
6	congestive heart failure ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001635
7	left ventricular hypertrophy ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001712
8	dyspnea ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002094
9	chest pain ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100749
10	weight loss ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001824
11	palpitations ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001962
12	abnormal cardiomyocyte morphology ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031331
13	left ventricular diastolic dysfunction ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025168
14	mitral regurgitation ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001653
15	cough ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0012735
16	right bundle branch block ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0011712
17	myocardial fibrosis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001685
18	t-wave inversion ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0010872
19	left atrial enlargement ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0031295
20	endocardial fibrosis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0006685
21	abnormal morphology of the chordae tendinae of the mitral valve ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0025523
22	abnormal tricuspid chordae tendinae morphology ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0031442
23	pericarditis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001701
24	aortic valve stenosis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001650
25	aortic regurgitation ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001659
26	abnormal heart valve morphology ⁵⁸		Frequent (79-30%)
27	arrhythmia ⁵⁸		Occasional (29-5%)

MGI Mouse Phenotypes related to Loeffler Endocarditis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system	MP:0005388	9.02	IL3 IL5 PDGFRA PRG2 THBD

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Drugs & Therapeutics for Loeffler Endocarditis

Search Clinical Trials, NIH Clinical Center for Loeffler Endocarditis

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Genetic Tests for Loeffler Endocarditis

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Anatomical Context for Loeffler Endocarditis

Organs/tissues related to Loeffler Endocarditis:

MalaCards : Heart, Thyroid, Lung, Liver

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Publications for Loeffler Endocarditis

Articles related to Loeffler Endocarditis:

(show top 50) (show all 113)

#	Title	Authors	PMID	Year
1	Case 305: Loeffler Endocarditis. ⁶²	Caruso S...Gentile G	35994399	2022
2	Loeffler Endocarditis Causing Heart Failure with Preserved Ejection Fraction (HFpEF): Characteristic Images and Diagnostic Pathway. ⁶²	Lupu S...Mitre A	36140558	2022
3	Multimodality imaging of eosinophilic endocarditis with intracardiac right ventricular thrombus. ⁶²	Wieser M...Grani C	35900252	2022
4	Hypereosinophilic Syndrome with Advanced-Stage Loeffler Endocarditis. ⁶²	Dzelebdzic S...Muniz JC	35818495	2022
5	Mixed-Etiology Restrictive Cardiomyopathy (Desminopathy and Hemochromatosis) with Complex Liver Lesions. ⁶²	Lutokhina Y...Zaklyazminskaya E	35456383	2022
6	Loeffler endocarditis with intracardiac thrombus: case report and literature review. ⁶²	Zhang Q...Zhang W	34961478	2021
7	A case of hypereosinophilic syndrome with Loeffler endocarditis successfully bridged to heart transplantation by biventricular mechanical support. ⁶²	Di Nora C...Livi U	33501681	2021
8	Normalization of left ventricular filling pressure after cardiac surgery for the Loeffler's endocarditis: a case report. ⁶²	Carcaterra A...Testuz A	34263118	2021
9	Follow-up CMR in a case of Loeffler endocarditis. ⁶²	Asadian S...Rezaeian N	33489229	2021
10	Loeffler Endocarditis as a Manifestation of Paraneoplastic Hypereosinophilia. ⁶²	Kelley BP...Sivak JA	33117933	2020
11	Loeffler Endocarditis and Associated Parasitosis: A Diagnostic Challenge. ⁶²	Latt H...Nair N	32550071	2020
12	Loeffler Endocarditis: A Manifestation of Hypereosinophilic Syndrome. ⁶²	Arustamyan M...Gorodin Kiliddar P	32337394	2020
13	Loeffler Endocarditis in Idiopathic Hypereosinophilic Syndrome Demonstrated by Magnetic Resonance Imaging Effectively Treated by Corticosteroids. ⁶²	Zhou Y...Ge J	31571804	2019
14	Morphologically proved ANCA positive Loeffler's pancarditis: medical and surgical treatment. ⁶²	Blagova OV...Fomin VV	31094483	2019
15	Loeffler's endocarditis with isolated left ventricular involvement on cardiac MRI. ⁶²	Kumar P...Malhi AS	31005861	2019
16	Loeffler Endocarditis: A Diagnosis Made with Cardiovascular Magnetic Resonance. ⁶²	Kalra DK...Goldberg A	30701721	2019
17	Loeffler endocarditis associated with a massive right intraventricular thrombus. ⁶²	Muniz MT...Garcia J	30006896	2018
18	Successful Medical Management of a Rare Loeffler Endocarditis Case. ⁶²	Gulel O...Elmali M	29968439	2018
19	Loeffler endocarditis in chronic eosinophilic leukemia with FIP1L1/PDGFRA rearrangement: full recovery with low dose imatinib. ⁶²	Kim DS...Choi CW	28651427	2018
20	Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature. ⁶²	Gao M...Zheng Y	29538200	2018
21	A Case of Loeffler Endocarditis That Showed Endomyocardial Systolic Dysfunction Detected by Layer Specific Strain Analysis. ⁶²	Jin X...Yang J	29151479	2017
22	Cardiac involvements in hypereosinophilia-associated syndrome: Case reports and a little review of the literature. ⁶²	Jin X...Yang J	28573678	2017
23	Usefulness of three-dimensional echocardiography in the assessment of valvular involvement in Loeffler endocarditis. ⁶²	Hernandez CM...Gallardo SM	28600838	2017
24	Eosinophilic endomyocardial disease. ⁶²	Liu VY...Buja LM	28157661	2017
25	When Hypereosinophilia Leads to Stroke. ⁶²	Chalayer E...Tardy B	30755950	2017
26	Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. ⁶²	Alam A...Jermyn R	28890659	2017
27	Loeffler endocarditis in young woman - a case report. ⁶²	Osovska NY...Knyazkova II	27883350	2016
28	ANCA-negative eosinophilic granulomatosis with polyangitis (EGPA) manifesting as a large intracardiac thrombus and glomerulonephritis with angionecrosis. ⁶²	Saito Y...Kobayashi Y	27591039	2016
29	Loeffler endocarditis: silent right ventricular myocardium! ⁶²	Cetin S...Hazirolan T	26980214	2016
30	Development of eosinophilic endomyocardial disease in a patient with episodic angioedema and eosinophilia. ⁶²	Wright BL...Gleich GJ	26563671	2016
31	Echocardiographic Changes in Eosinophilic Endocarditis Induced by Churg-Strauss Syndrome. ⁶²	Masaki N...Nishioka T	27725542	2016
32	Loeffler endocarditis in a patient with non-Hodgkin's lymphoma. ⁶²	Aguiar Rosa S...Cruz Ferreira R	27004546	2016
33	Hematological dyspnea: A rare cause with gratifying recovery. ⁶²	Gupta A...Nanjappa MC	30671146	2015
34	Restrictive myocardium with an unusual pattern of apical hypertrophic cardiomyopathy. ⁶²	Sato T...Nakatani T	25804825	2015
35	Cutaneous B-lymphoblastic lymphoma with IL3/IgH translocation presenting with hypereosinophilia and acute endocarditis. ⁶²	Bomken S...Windebank K	25382309	2015
36	Biopsy-proven Loeffler endocarditis successfully treated with steroids. ⁶²	Inoue T...Kawai C	25712061	2015
37	Severe mitral regurgitation caused by eosinophilic endocarditis. ⁶²	van Dongen IM...Driessen RGH	30546520	2014
38	Three-dimensional speckle-tracking echocardiography in Loeffler endocarditis: case report from the MAGYAR-Path Study. ⁶²	Nemes A...Forster T	23846825	2014
39	Confirmation of diagnosis and graduation of inflammatory activity of Loeffler endocarditis by hybrid positron emission tomography/magnetic resonance imaging. ⁶²	Langwieser N...Ibrahim T	24713639	2014
40	Loeffler endocarditis in a pediatric patient. ⁶²	Keivanidou A...Athanasiadou F	23802753	2014
41	Myeloproliferative hypereosinophilic syndrome presenting as cardiac failure and response to imatinib. ⁶²	Desai N...Patil P	24603276	2014
42	Loeffler endocarditis of the left ventricle: cardiac magnetic resonance findings. ⁶²	Bonanad C...Lopez-Lereu MP	23706937	2013
43	Eosinophilic endocarditis and Strongyloides stercoralis. ⁶²	Thaden J...Nishimura R	23672985	2013
44	Crohn's disease and nontropical endomyocardial fibrosis. ⁶²	Ennezat PV...Vincentelli A	23839293	2013
45	[Loeffler's endocarditis--a case report]. ⁶²	Faria R...Gomes V	22608505	2012
46	Gadolinium-enhanced cardiovascular magnetic resonance for the detection and characterization of Loeffler endocarditis in patients with hypereosinophilic syndrome. ⁶²	Ibrahim T...Schomig A	21963210	2011
47	Eosinophil granule protein localization in eosinophilic endomyocardial disease. ⁶²	Wright BL...Gleich GJ	21751935	2011
48	A case of systemic lupus erythematosus presenting with hypereosinophilia and Loeffler endocarditis. ⁶²	Aydogdu S...Cetin M	21125980	2010
49	Magnetic resonance imaging of a hypereosinophilic endocarditis with apical thrombotic obliteration in Churg-Strauss syndrome complicated with acute abdominal aortic embolic occlusion. ⁶²	Esposito A...Del Maschio A	19167111	2010
50	Loeffler endocarditis: magnetic resonance imaging features of pre- and post-operation. ⁶²	Fan ZM...Zhang ZQ	20819614	2010

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Genes for Loeffler Endocarditis

Genes related to Loeffler Endocarditis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	6.53	DISEASES inferred ¹⁴
2	RNASE3	Ribonuclease A Family Member 3	Protein Coding	6.2	DISEASES inferred ¹⁴
3	PRG2	Proteoglycan 2, Pro Eosinophil Major Basic Protein	Protein Coding	5.95	DISEASES inferred ¹⁴
4	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	5.66	DISEASES inferred ¹⁴
5	THBD	Thrombomodulin	Protein Coding	5.05	DISEASES inferred ¹⁴
6	RNASE2	Ribonuclease A Family Member 2	Protein Coding	4.97	DISEASES inferred ¹⁴
7	IL5	Interleukin 5	Protein Coding	4.71	DISEASES inferred ¹⁴
8	TNNT2	Troponin T2, Cardiac Type	Protein Coding	4.48	DISEASES inferred ¹⁴
9	IL3	Interleukin 3	Protein Coding	4.35	DISEASES inferred ¹⁴

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Variations for Loeffler Endocarditis

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Expression for Loeffler Endocarditis

Search GEO for disease gene expression data for Loeffler Endocarditis.

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Pathways for Loeffler Endocarditis

Pathways related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	IL3-mediated signaling events ⁶¹ Show member pathways GMCSF-mediated signaling events ⁶¹ IL5-mediated signaling events ⁶¹	11.21	IL5 IL3
2	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.15	IL5 IL3
3	Cardiac progenitor differentiation ⁷⁴	10.98	TNNT2 PDGFRA
4	Signaling by PDGFR in disease ⁶⁶ Show member pathways Signaling by cytosolic PDGFRA and PDGFRB fusion proteins ⁶⁶ Signaling by membrane-tethered fusions of PDGFRA or PDGFRB ⁶⁶ Signaling by PDGFRA extracellular domain mutants ⁶⁶ Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants ⁶⁶	10.87	PDGFRA FIP1L1
5	Cytokines and inflammatory response ⁷⁴	10.42	IL5 IL3
6	G-protein signaling_Rap2B regulation pathway ²²	9.83	PRG2 PDGFRA IL5 IL3

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GO Terms for Loeffler Endocarditis

Biological processes related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RNA catabolic process	GO:0006401	9.71	RNASE3 RNASE2
2	RNA phosphodiester bond hydrolysis	GO:0090501	9.67	RNASE3 RNASE2
3	chemotaxis	GO:0006935	9.65	RNASE3 RNASE2 PDGFRA
4	innate immune response in mucosa	GO:0002227	9.62	RNASE3 RNASE2
5	negative regulation of platelet activation	GO:0010544	9.26	THBD PDGFRA
6	RNA metabolic process	GO:0016070	9.16	RNASE3 RNASE2
7	induction of bacterial agglutination	GO:0043152	8.8	RNASE3 RNASE2

Molecular functions related to Loeffler Endocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ribonuclease activity	GO:0004540	8.92	RNASE3 RNASE2

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Sources for Loeffler Endocarditis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LFF001 MIFTS: 39	Loeffler Endocarditis Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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