MCID: LFF002
MIFTS: 29

Loeffler Syndrome

Categories: Immune diseases, Respiratory diseases
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Aliases & Classifications for Loeffler Syndrome

MalaCards integrated aliases for Loeffler Syndrome:

Name: Loeffler Syndrome 11 14
Simple Pulmonary Eosinophilia 71
Loeffler's Pneumonia 11
Loffler's Syndrome 11

Classifications:



External Ids:

Disease Ontology 11 DOID:9503
MeSH 43 D011657
NCIt 49 C35301
SNOMED-CT 68 64936001
UMLS 71 C0242459

Summaries for Loeffler Syndrome

Disease Ontology: 11 An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection.

MalaCards based summary: Loeffler Syndrome, also known as simple pulmonary eosinophilia, is related to eosinophilic pneumonia and ascaris lumbricoides infection, and has symptoms including coughing An important gene associated with Loeffler Syndrome is IL33 (Interleukin 33), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include lung, and related phenotypes are immune system and respiratory system

Related Diseases for Loeffler Syndrome

Diseases related to Loeffler Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 eosinophilic pneumonia 30.0 IL5 IL13 FIP1L1
2 ascaris lumbricoides infection 30.0 STH IL5 IL13
3 common cold 30.0 IL5 IL33 IL13
4 bronchitis 29.8 IL5 IL13 CCR3
5 pulmonary eosinophilia 29.8 PRG2 IL5 IL13 CCR3
6 conjunctivitis 29.7 IL5 IL33 IL1RL1 IL13
7 churg-strauss syndrome 29.7 PRG2 IL5
8 strongyloidiasis 29.7 STH IL5 IL13
9 hypereosinophilic syndrome 29.6 PRG2 IL5 IL13 FIP1L1 CCR3
10 nut allergy 10.2 IL5 IL13
11 hypereosinophilic syndrome, idiopathic 10.2 IL5 FIP1L1
12 aztreonam allergy 10.2 IL5 IL13
13 nickel allergic contact dermatitis 10.2 IL5 IL13
14 chromium allergic contact dermatitis 10.2 IL5 IL13
15 cefaclor allergy 10.2 IL5 IL13
16 respiratory syncytial virus infectious disease 10.2 IL5 IL13
17 persistent severe asthma 10.2 IL5 IL13
18 disseminated eosinophilic collagen disease 10.2 IL5 FIP1L1
19 papillary conjunctivitis 10.2 IL5 IL13
20 mononeuritis multiplex 10.2 IL5 FIP1L1
21 cough variant asthma 10.2 IL5 IL13
22 norwegian scabies 10.2 IL5 IL13
23 aspirin-induced respiratory disease 10.2 IL5 IL13
24 cow milk allergy 10.2 IL5 IL13
25 milk allergy 10.2 IL5 IL13
26 angiostrongyliasis 10.2 IL5 IL13
27 eosinophilic meningitis 10.2 IL5 IL13
28 metal allergy 10.2 IL5 IL13
29 mikulicz disease 10.2 IL5 IL13
30 eosinophilia-myalgia syndrome 10.2 IL5 FIP1L1
31 esophageal candidiasis 10.2 IL5 IL13
32 trichinosis 10.2 IL5 IL13
33 vasomotor rhinitis 10.1 IL5 IL13
34 giant papillary conjunctivitis 10.1 IL5 IL13
35 chronic meningitis 10.1 IL5 IL13
36 mucocutaneous leishmaniasis 10.1 IL5 IL13
37 exercise-induced bronchoconstriction 10.1 IL5 IL13
38 pollen allergy 10.1 IL5 IL13
39 egg allergy 10.1 IL5 IL13
40 igg4-related disease 10.1 IL5 IL13
41 drug allergy 10.1 IL5 IL13
42 chronic eosinophilic leukemia 10.1 IL5 FIP1L1
43 nasopharyngitis 10.1 IL5 IL13
44 pneumothorax, primary spontaneous 10.1 LRRC43 IL33 IL1RL1
45 status asthmaticus 10.1 IL5 IL13
46 dermatitis 10.1 IL5 IL33 IL13
47 thunderstorm triggered asthma 10.1 IL5 IL33 IL13
48 near-fatal asthma 10.1 IL5 IL33 IL13
49 posterior uveitis 10.1 IL5 IL13
50 t2-low asthma 10.1 IL5 IL33 IL13

Graphical network of the top 20 diseases related to Loeffler Syndrome:



Diseases related to Loeffler Syndrome

Symptoms & Phenotypes for Loeffler Syndrome

UMLS symptoms related to Loeffler Syndrome:


coughing

MGI Mouse Phenotypes related to Loeffler Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.76 CCR3 IL13 IL1RL1 IL33 IL5 PRG2
2 respiratory system MP:0005388 9.43 CCR3 IL13 IL33 IL5 PRG2 RAG2
3 hematopoietic system MP:0005397 9.23 CCR3 IL13 IL1RL1 IL33 IL5 PRG2

Drugs & Therapeutics for Loeffler Syndrome

Search Clinical Trials, NIH Clinical Center for Loeffler Syndrome

Genetic Tests for Loeffler Syndrome

Anatomical Context for Loeffler Syndrome

Organs/tissues related to Loeffler Syndrome:

MalaCards : Lung

Publications for Loeffler Syndrome

Articles related to Loeffler Syndrome:

(show all 46)
# Title Authors PMID Year
1
Pregnant lady with eosinophilia: common cause, uncommon association. 62
35035052 2022
2
Loeffler's syndrome in a child: A rare radiological and histopathological diagnosis. 62
34840639 2022
3
Diagnosis of EGPA Syndrome in a Patient With Chronic Polypoid Rhinosinusitis Presenting as Loeffler Syndrome. 62
31565994 2021
4
Rare presentation of haemobilia and Loeffler's pneumonia in a child by ascaris lumbricoides. 62
31466983 2019
5
Molecular Confirmation of Ascaris suum: Further Investigation into the Zoonotic Origin of Infection in an 8-Year-Old Boy with Loeffler Syndrome. 62
30085905 2018
6
Loeffler's syndrome: an interesting case report. 62
24931460 2016
7
[Travel-associated pneumonias]. 62
25290923 2014
8
[Loeffler's syndrome mimicking bronchial asthma and pneumonia in a child: case report]. 62
24412873 2013
9
[Strongyloidosis caused Loeffler's syndrome in an immunosuppressed patient who uses cronic steroid]. 62
23619049 2013
10
[Malabsorption syndrome due to Strongyloides stercoralis associated with Loeffler syndrome in a 29-year-old woman]. 62
16790183 2006
11
Loffler's syndrome associated with Clonorchis sinensis infestation. 62
14717238 2003
12
[Loeffler syndrome and Mycoplasma pneumonitis. A case report]. 62
12070484 2002
13
[Tropical endomyocardial fibrosis or Davies disease. A case report]. 62
11181314 2001
14
Ascariasis and hookworm. 62
9195678 1997
15
[Chronic course of eosinophilic pneumonia in infection with ascaris lumbricoides]. 62
7724507 1995
16
[A case of extrinsic allergic alveolitis in a shoe factory worker]. 62
1478527 1992
17
[Loeffler syndrome in a child treated with aspirin]. 62
2344984 1990
18
[A rare case of the meningoencephalitis form of the Loeffler syndrome]. 62
3577504 1987
19
Nonspecific allergic granulomatosis in the lungs of mice infected with large but not small inocula of the canine ascarid, Toxocara canis. 62
3742887 1986
20
[Eosinophilic pulmonary infiltrate (considerations of a case of Loeffler syndrome)]. 62
6296981 1982
21
Ultrastructure of the lung in Loeffler's pneumonia. 62
1115077 1975
22
Loffler's syndrome. Report of a case associated with the administration of aurothioglucose (Solganal). 62
13703724 1960
23
Loffler's syndrome: report of a case associated with administration of mephenesin carbamate (tolseram). 62
13521594 1958
24
[Pneumonitis with eosinophilia; Loeffler syndrome]. 62
13554102 1957
25
[Parietal fibroplastic endocarditis with blood eosinophilia (Loffler's syndrome) and its relation to parietal endocardial fibroses]. 62
13454776 1957
26
Loeffler's pneumonia associated with hypogammaglobulinemia. 62
13406682 1957
27
[Endemic of the so-called Loeffler syndrome]. 62
12993072 1952
28
[Loeffler syndrome]. 62
13012690 1952
29
[A case of transient pulmonary eosinophilia (Loffler's syndrome)]. 62
13026548 1952
30
Loffler's syndrome probably due to sulphanilamide medication; case report. 62
14942891 1952
31
[Transitory pulmonary opacities; Loeffler syndrome and so-called Fanconi-Hegglin pseudosyphilitic bronchopneumonia]. 62
14953111 1952
32
Loffler's syndrome; report of cases in twins. 62
14850314 1951
33
[A case of Loeffler syndrome]. 62
14807587 1950
34
A Loeffler Syndrome Case 62
18148173 1949
35
On a case of Loeffler syndrome with six subsequent lung infiltrates. 62
18136410 1949
36
Multinodular and hemoptotic loeffler syndrome of ascarid origin. 62
18894199 1948
37
Loffler's syndrome. 62
18879475 1948
38
On the pathogenesis and etiology of volatile lung infiltrates with blood eosinophilia (Loffler's syndrome). 62
18879263 1948
39
On two cases of eosinophilic fleeting lung infiltrate; Loeffler syndrome. 62
18888570 1948
40
Loeffler syndrome. 62
18860621 1947
41
Loeffler syndrome allergy reaction in a carrier of whipworms. 62
20269524 1947
42
Parinaud conjunctivitis and Loeffler syndrome. 62
20344193 1947
43
Loeffler syndrome in micronodular form in an asthmatic. 62
21019634 1946
44
Loeffler syndrome. 62
21016087 1945
45
Fugitive pulmonary infiltrations with blood eosinophilia (ie Loeffler syndrome). 62
21012089 1945
46
Loeffler syndrome. 62
20984013 1945

Variations for Loeffler Syndrome

Expression for Loeffler Syndrome

Search GEO for disease gene expression data for Loeffler Syndrome.

Pathways for Loeffler Syndrome

GO Terms for Loeffler Syndrome

Biological processes related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.02 PRG2 IL5 IL1RL1 IL13 CCR3
2 positive regulation of interleukin-4 production GO:0032753 9.71 PRG2 IL33
3 positive regulation of interleukin-5 production GO:0032754 9.67 IL33 IL1RL1
4 negative regulation of T-helper 1 type immune response GO:0002826 9.56 IL33 IL1RL1
5 interleukin-33-mediated signaling pathway GO:0038172 9.46 IL33 IL1RL1
6 positive regulation of immunoglobulin production GO:0002639 9.43 IL5 IL33 IL13
7 positive regulation of macrophage activation GO:0043032 9.1 IL33 IL1RL1 IL13

Sources for Loeffler Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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