MCID: LFF002
MIFTS: 24

Loeffler Syndrome

Categories: Respiratory diseases, Blood diseases

Aliases & Classifications for Loeffler Syndrome

MalaCards integrated aliases for Loeffler Syndrome:

Name: Loeffler Syndrome 12 15
Simple Pulmonary Eosinophilia 73
Loeffler's Pneumonia 12
Loffler's Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9503
ICD10 33 J82
MeSH 44 D011657
NCIt 50 C35301
SNOMED-CT 68 123261002 64936001
UMLS 73 C0242459

Summaries for Loeffler Syndrome

Disease Ontology : 12 An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection.

MalaCards based summary : Loeffler Syndrome, also known as simple pulmonary eosinophilia, is related to eosinophilic pneumonia and fiedler's myocarditis, and has symptoms including coughing An important gene associated with Loeffler Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways is A-beta Pathways: Uptake and Degradation. The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include lung.

Wikipedia : 76 Löffler\'s syndrome or Loeffler\'s syndrome is a disease in which eosinophils accumulate in the lung in... more...

Related Diseases for Loeffler Syndrome

Graphical network of the top 20 diseases related to Loeffler Syndrome:



Diseases related to Loeffler Syndrome

Symptoms & Phenotypes for Loeffler Syndrome

UMLS symptoms related to Loeffler Syndrome:


coughing

Drugs & Therapeutics for Loeffler Syndrome

Drugs for Loeffler Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved 10102-43-9 145068 160954

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Usefulness of Exhaled NO in the Differential Diagnosis Acute Eosinophilic Pneumonia and Bacterial Pneumonia Unknown status NCT01152424

Search NIH Clinical Center for Loeffler Syndrome

Genetic Tests for Loeffler Syndrome

Anatomical Context for Loeffler Syndrome

MalaCards organs/tissues related to Loeffler Syndrome:

41
Lung

Publications for Loeffler Syndrome

Articles related to Loeffler Syndrome:

# Title Authors Year
1
Simple pulmonary eosinophilia associated with clozapine treatment. ( 25514065 )
2015
2
Simple pulmonary eosinophilia found on follow-up computed tomography of oncologic patients. ( 25082475 )
2014
3
Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases. ( 16374077 )
2005

Variations for Loeffler Syndrome

Expression for Loeffler Syndrome

Search GEO for disease gene expression data for Loeffler Syndrome.

Pathways for Loeffler Syndrome

Pathways related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 ACE CD40LG

GO Terms for Loeffler Syndrome

Cellular components related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 ACE CD40LG

Molecular functions related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 8.96 ACE ENSG00000264813
2 peptidyl-dipeptidase activity GO:0008241 8.62 ACE ENSG00000264813

Sources for Loeffler Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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