MCID: LFF002
MIFTS: 23

Loeffler Syndrome

Categories: Blood diseases, Respiratory diseases

Aliases & Classifications for Loeffler Syndrome

MalaCards integrated aliases for Loeffler Syndrome:

Name: Loeffler Syndrome 12 15
Simple Pulmonary Eosinophilia 72
Loeffler's Pneumonia 12
Loffler's Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9503
MeSH 44 D011657
NCIt 50 C35301
SNOMED-CT 68 64936001
ICD10 33 J82
UMLS 72 C0242459

Summaries for Loeffler Syndrome

Disease Ontology : 12 An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection.

MalaCards based summary : Loeffler Syndrome, also known as simple pulmonary eosinophilia, is related to eosinophilic pneumonia and hypereosinophilic syndrome, and has symptoms including coughing An important gene associated with Loeffler Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways is A-beta Pathways: Uptake and Degradation. Affiliated tissues include lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Loeffler Syndrome

Diseases related to Loeffler Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 eosinophilic pneumonia 11.2
2 hypereosinophilic syndrome 10.2
3 pulmonary eosinophilia 10.2
4 pneumonia 10.2
5 endocarditis 10.1
6 clonorchiasis 10.1
7 agammaglobulinemia 10.0
8 vasculitis 10.0
9 meningoencephalitis 10.0
10 bronchopneumonia 10.0
11 rheumatic disease 10.0
12 iga glomerulonephritis 9.5 CD40LG ACE
13 systemic scleroderma 9.5 CD40LG ACE
14 systemic lupus erythematosus 9.5 CD40LG ACE
15 connective tissue disease 9.4 CD40LG ACE
16 myocardial infarction 9.2 CD40LG ACE

Graphical network of the top 20 diseases related to Loeffler Syndrome:



Diseases related to Loeffler Syndrome

Symptoms & Phenotypes for Loeffler Syndrome

UMLS symptoms related to Loeffler Syndrome:


coughing

GenomeRNAi Phenotypes related to Loeffler Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 8.92 ACE CD40LG
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 8.92 ACE CD40LG

Drugs & Therapeutics for Loeffler Syndrome

Search Clinical Trials , NIH Clinical Center for Loeffler Syndrome

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cortisone acetate
Dexamethasone
Hydrocortisone
Methylprednisolone
Prednisolone
Prednisone

Genetic Tests for Loeffler Syndrome

Anatomical Context for Loeffler Syndrome

MalaCards organs/tissues related to Loeffler Syndrome:

41
Lung

Publications for Loeffler Syndrome

Articles related to Loeffler Syndrome:

(show all 32)
# Title Authors PMID Year
1
Molecular Confirmation of Ascaris suum: Further Investigation into the Zoonotic Origin of Infection in an 8-Year-Old Boy with Loeffler Syndrome. 38
30085905 2018
2
Cardiopulmonary and Gastrointestinal Manifestations of Eosinophil- associated Diseases and Idiopathic Hypereosinophilic Syndromes: Multimodality Imaging Approach. 38
26963455 2016
3
Loeffler's syndrome: an interesting case report. 38
24931460 2016
4
Eosinophilic Lung Disease: Accompanied with 12 Cases. 38
29404099 2015
5
[A clinical analysis of twenty-five cases of eosinophilic lung disease]. 38
26080822 2015
6
Simple pulmonary eosinophilia associated with clozapine treatment. 38
25514065 2015
7
Simple pulmonary eosinophilia found on follow-up computed tomography of oncologic patients. 38
25082475 2014
8
[Travel-associated pneumonias]. 38
25290923 2014
9
[Strongyloidosis caused Loeffler's syndrome in an immunosuppressed patient who uses cronic steroid]. 38
23619049 2013
10
Pulmonary eosinophilic infiltrates. 38
21428117 2010
11
Pulmonary eosinophilia. 38
19618037 2009
12
Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview. 38
17495282 2007
13
[Malabsorption syndrome due to Strongyloides stercoralis associated with Loeffler syndrome in a 29-year-old woman]. 38
16790183 2006
14
Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases. 38
16374077 2005
15
[Loeffler syndrome and Mycoplasma pneumonitis. A case report]. 38
12070484 2002
16
[Tropical endomyocardial fibrosis or Davies disease. A case report]. 38
11181314 2001
17
Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients. 38
10966710 2000
18
[A mild case of acute eosinophilic pneumonia]. 38
9866986 1998
19
The spectrum of eosinophilic lung disease: radiologic findings. 38
9386285 1997
20
Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose. 38
8520792 1995
21
[Löffler's syndrome (simple pulmonary eosinophilia)]. 38
8152008 1994
22
[Pulmonary eosinophilia]. 38
8492456 1993
23
[A case of extrinsic allergic alveolitis in a shoe factory worker]. 38
1478527 1992
24
[Loeffler syndrome in a child treated with aspirin]. 38
2344984 1990
25
[A rare case of the meningoencephalitis form of the Loeffler syndrome]. 38
3577504 1987
26
Loeffler's syndrome: an uncommon adverse reaction to imipramine. 38
3559155 1986
27
[Eosinophilic pulmonary infiltrate (considerations of a case of Loeffler syndrome)]. 38
6296981 1982
28
[Pneumonitis with eosinophilia; Loeffler syndrome]. 38
13554102 1957
29
[Endemic of the so-called Loeffler syndrome]. 38
12993072 1952
30
[Loeffler syndrome]. 38
13012690 1952
31
[Transitory pulmonary opacities; Loeffler syndrome and so-called Fanconi-Hegglin pseudosyphilitic bronchopneumonia]. 38
14953111 1952
32
[A case of Loeffler syndrome]. 38
14807587 1950

Variations for Loeffler Syndrome

Expression for Loeffler Syndrome

Search GEO for disease gene expression data for Loeffler Syndrome.

Pathways for Loeffler Syndrome

Pathways related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 CD40LG ACE

GO Terms for Loeffler Syndrome

Cellular components related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD40LG ACE

Sources for Loeffler Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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