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MCID: LFF002
MIFTS: 31

Loeffler Syndrome

Categories: Blood diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Loeffler Syndrome

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MalaCards integrated aliases for Loeffler Syndrome:

Name: Loeffler Syndrome 12 15
Simple Pulmonary Eosinophilia 71
Loeffler's Pneumonia 12
Loffler's Syndrome 12

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9503
MeSH 43 D011657
NCIt 49 C35301
SNOMED-CT 67 64936001
ICD10 32 J82
UMLS 71 C0242459
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Summaries for Loeffler Syndrome

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Disease Ontology : 12 An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection.

MalaCards based summary : Loeffler Syndrome, also known as simple pulmonary eosinophilia, is related to ascaris lumbricoides infection and pulmonary eosinophilia, and has symptoms including coughing An important gene associated with Loeffler Syndrome is FIP1L1 (Factor Interacting With PAPOLA And CPSF1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include lung, skin and t cells, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Loeffler Syndrome

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Diseases related to Loeffler Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 ascaris lumbricoides infection 30.3 IL5 IL13
2 pulmonary eosinophilia 30.2 PRG2 IL5 IL13
3 pneumonia 30.0 IL5 IL13 CD40LG
4 eosinophilic pneumonia 30.0 IL5 IL33 IL13
5 hypereosinophilic syndrome 29.9 PRG2 IL5 IL13 FIP1L1
6 hypereosinophilic syndrome, idiopathic 10.3 IL5 FIP1L1
7 disseminated eosinophilic collagen disease 10.3 IL5 FIP1L1
8 atopic keratoconjunctivitis 10.3 PRG2 IL5
9 cytokine deficiency 10.2 IL5 IL13
10 aztreonam allergy 10.2 IL5 IL13
11 ceftriaxone allergy 10.2 IL5 IL13
12 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL5 IL13
13 respiratory syncytial virus infectious disease 10.2 IL5 IL13
14 cefaclor allergy 10.2 IL5 IL13
15 cefuroxime allergy 10.2 IL5 IL13
16 orange allergy 10.2 IL5 IL13
17 loiasis 10.2 IL5 IL13
18 chronic eosinophilic leukemia 10.2 IL5 FIP1L1
19 mikulicz disease 10.2 IL5 IL13
20 vernal keratoconjunctivitis 10.2 IL5 IL13
21 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IL5 IL13
22 intrinsic asthma 10.2 IL5 IL13
23 paragonimiasis 10.2 IL5 IL13
24 angiostrongyliasis 10.2 IL5 IL13
25 chronic rhinitis 10.2 IL5 IL13
26 nut allergy 10.2 IL5 IL13
27 filarial elephantiasis 10.2 IL5 IL13
28 intestinal schistosomiasis 10.2 IL5 IL13
29 allergic bronchopulmonary aspergillosis 10.1 IL5 FLNC
30 urinary schistosomiasis 10.1 IL5 IL13
31 latex allergy 10.1 IL5 IL13
32 peanut allergy 10.1 IL5 IL13
33 lung abscess 10.1 FLNC CD40LG
34 fungal meningitis 10.1 FLNC CD40LG
35 ige responsiveness, atopic 10.1 IL5 IL13
36 endocarditis 10.1
37 clonorchiasis 10.1
38 pustulosis palmaris et plantaris 10.1 IL5 CD40LG
39 loeffler endocarditis 10.1 PRG2 IL5 FIP1L1
40 primary systemic mycosis 10.1 FLNC CD40LG
41 chronic meningitis 10.1 IL5 CD40LG
42 endomyocardial fibrosis 10.1 PRG2 IL5 FIP1L1
43 mite infestation 10.1 IL5 CD40LG
44 posterior uveitis 10.1 IL5 IL13
45 pneumocystosis 10.0 FLNC CD40LG
46 eosinophilic gastritis 10.0 IL5 IL13 FIP1L1
47 cholecystitis 10.0
48 agammaglobulinemia 10.0
49 ascaridiasis 10.0
50 vasculitis 10.0

Graphical network of the top 20 diseases related to Loeffler Syndrome:



Diseases related to Loeffler Syndrome
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Symptoms & Phenotypes for Loeffler Syndrome

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UMLS symptoms related to Loeffler Syndrome:


coughing

MGI Mouse Phenotypes related to Loeffler Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 CD40LG IL13 IL1RL1 IL33 IL5 PRG2
2 immune system MP:0005387 9.7 CD40LG IL13 IL1RL1 IL33 IL5 PRG2
3 reproductive system MP:0005389 9.43 CD40LG IL13 IL33 IL5 KNDC1 RAG2
4 respiratory system MP:0005388 9.1 FLNC IL13 IL33 IL5 PRG2 RAG2
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Drugs & Therapeutics for Loeffler Syndrome

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Search Clinical Trials , NIH Clinical Center for Loeffler Syndrome

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Genetic Tests for Loeffler Syndrome

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Anatomical Context for Loeffler Syndrome

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MalaCards organs/tissues related to Loeffler Syndrome:

40
Lung, Skin, T Cells, B Cells
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Publications for Loeffler Syndrome

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Articles related to Loeffler Syndrome:

(show all 33)
# Title Authors PMID Year
1
Diagnosis of EGPA Syndrome in a Patient With Chronic Polypoid Rhinosinusitis Presenting as Loeffler Syndrome. 61
31565994 2019
2
Molecular Confirmation of Ascaris suum: Further Investigation into the Zoonotic Origin of Infection in an 8-Year-Old Boy with Loeffler Syndrome. 61
30085905 2018
3
Cardiopulmonary and Gastrointestinal Manifestations of Eosinophil- associated Diseases and Idiopathic Hypereosinophilic Syndromes: Multimodality Imaging Approach. 61
26963455 2016
4
Loeffler's syndrome: an interesting case report. 61
24931460 2016
5
Eosinophilic Lung Disease: Accompanied with 12 Cases. 61
29404099 2015
6
[A clinical analysis of twenty-five cases of eosinophilic lung disease]. 61
26080822 2015
7
Simple pulmonary eosinophilia associated with clozapine treatment. 61
25514065 2015
8
Simple pulmonary eosinophilia found on follow-up computed tomography of oncologic patients. 61
25082475 2014
9
[Travel-associated pneumonias]. 61
25290923 2014
10
[Strongyloidosis caused Loeffler's syndrome in an immunosuppressed patient who uses cronic steroid]. 61
23619049 2013
11
Pulmonary eosinophilic infiltrates. 61
21428117 2010
12
Pulmonary eosinophilia. 61
19618037 2009
13
Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview. 61
17495282 2007
14
[Malabsorption syndrome due to Strongyloides stercoralis associated with Loeffler syndrome in a 29-year-old woman]. 61
16790183 2006
15
Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases. 61
16374077 2005
16
[Loeffler syndrome and Mycoplasma pneumonitis. A case report]. 61
12070484 2002
17
[Tropical endomyocardial fibrosis or Davies disease. A case report]. 61
11181314 2001
18
Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients. 61
10966710 2000
19
[A mild case of acute eosinophilic pneumonia]. 61
9866986 1998
20
The spectrum of eosinophilic lung disease: radiologic findings. 61
9386285 1997
21
Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose. 61
8520792 1995
22
[Löffler's syndrome (simple pulmonary eosinophilia)]. 61
8152008 1994
23
[Pulmonary eosinophilia]. 61
8492456 1993
24
[A case of extrinsic allergic alveolitis in a shoe factory worker]. 61
1478527 1992
25
[Loeffler syndrome in a child treated with aspirin]. 61
2344984 1990
26
[A rare case of the meningoencephalitis form of the Loeffler syndrome]. 61
3577504 1987
27
Loeffler's syndrome: an uncommon adverse reaction to imipramine. 61
3559155 1986
28
[Eosinophilic pulmonary infiltrate (considerations of a case of Loeffler syndrome)]. 61
6296981 1982
29
[Pneumonitis with eosinophilia; Loeffler syndrome]. 61
13554102 1957
30
[Loeffler syndrome]. 61
13012690 1952
31
[Endemic of the so-called Loeffler syndrome]. 61
12993072 1952
32
[Transitory pulmonary opacities; Loeffler syndrome and so-called Fanconi-Hegglin pseudosyphilitic bronchopneumonia]. 61
14953111 1952
33
[A case of Loeffler syndrome]. 61
14807587 1950
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Variations for Loeffler Syndrome

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Expression for Loeffler Syndrome

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Search GEO for disease gene expression data for Loeffler Syndrome.
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Pathways for Loeffler Syndrome

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Pathways related to Loeffler Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.63 RAG2 PRG2 IL5 IL33 IL1RL1 IL13
2
Cytokine Signaling in Immune system 65
Show member pathways
 12.84 RAG2 IL5 IL33 IL1RL1 IL13 CD40LG
3
Allograft rejection 1 36
Show member pathways
 12.36 PRG2 IL5 IL13 CD40LG
4
Innate Lymphoid Cell Differentiation Pathways 64
11.16 IL5 IL33 IL1RL1 IL13
5
Primary immunodeficiency 36
11.06 RAG2 CD40LG
6
Inflammatory Response Pathway 1
10.98 IL5 CD40LG
7
Cytokines and Inflammatory Response 1
10.9 IL5 IL13
8
Development and heterogeneity of the ILC family 1
10.84 IL5 IL33 IL13
9
OX40 Pathway 63
10.82 IL5 IL13
10
Th2 Differentiation Pathway 64
10.59 IL5 IL33 IL1RL1 IL13
11
G-protein signaling_Rap2B regulation pathway 22
10.57 PRG2 IL5 IL13 CD40LG
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GO Terms for Loeffler Syndrome

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Cellular components related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 PRG2 IL5 IL33 IL1RL1 IL13 CD40LG

Biological processes related to Loeffler Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 IL5 IL1RL1 IL13
2 immune response GO:0006955 9.55 PRG2 IL5 IL1RL1 IL13 CD40LG
3 positive regulation of B cell proliferation GO:0030890 9.48 IL5 IL13
4 negative regulation of interferon-gamma production GO:0032689 9.46 IL33 IL1RL1
5 positive regulation of interleukin-4 production GO:0032753 9.43 IL33 CD40LG
6 positive regulation of chemokine secretion GO:0090197 9.4 IL33 IL1RL1
7 positive regulation of immunoglobulin secretion GO:0051024 9.37 IL5 IL33
8 positive regulation of interleukin-5 production GO:0032754 9.32 IL33 IL1RL1
9 negative regulation of T-helper 1 type immune response GO:0002826 9.26 IL33 IL1RL1
10 interleukin-33-mediated signaling pathway GO:0038172 8.96 IL33 IL1RL1
11 positive regulation of macrophage activation GO:0043032 8.8 IL33 IL1RL1 IL13

Molecular functions related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IL5 IL33 IL13 CD40LG
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Sources for Loeffler Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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