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MCID: LFF002
MIFTS: 30

Loeffler Syndrome

Categories: Immune diseases, Respiratory diseases
Genes Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Loeffler Syndrome

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MalaCards integrated aliases for Loeffler Syndrome:

Name: Loeffler Syndrome 12 15
Simple Pulmonary Eosinophilia 70
Loeffler's Pneumonia 12
Loffler's Syndrome 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases Respiratory diseases
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External Ids:

Disease Ontology 12 DOID:9503
MeSH 44 D011657
NCIt 50 C35301
SNOMED-CT 67 64936001
ICD10 32 J82.89
UMLS 70 C0242459
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Summaries for Loeffler Syndrome

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Disease Ontology : 12 An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection.

MalaCards based summary : Loeffler Syndrome, also known as simple pulmonary eosinophilia, is related to ascaris lumbricoides infection and eosinophilic pneumonia, and has symptoms including coughing An important gene associated with Loeffler Syndrome is IL33 (Interleukin 33), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Related phenotypes are hematopoietic system and digestive/alimentary

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Related Diseases for Loeffler Syndrome

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Diseases related to Loeffler Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 ascaris lumbricoides infection 30.1 IL5 IL13
2 eosinophilic pneumonia 30.0 IL5 IL33 IL13
3 pulmonary eosinophilia 30.0 IL5 IL13 CCR3
4 conjunctivitis 29.9 IL5 IL33 IL13
5 hypereosinophilic syndrome 29.8 IL5 IL13 FIP1L1 CCR3
6 loeffler endocarditis 10.2 IL5 FIP1L1
7 hypereosinophilic syndrome, idiopathic 10.2 IL5 FIP1L1
8 pneumothorax, primary spontaneous 10.2 IL33 IL1RL1
9 disseminated eosinophilic collagen disease 10.2 IL5 FIP1L1
10 endomyocardial fibrosis 10.2 IL5 FIP1L1
11 cytokine deficiency 10.2 IL5 IL13
12 eosinophilia-myalgia syndrome 10.2 IL5 FIP1L1
13 aztreonam allergy 10.2 IL5 IL13
14 cefaclor allergy 10.2 IL5 IL13
15 cefuroxime allergy 10.2 IL5 IL13
16 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL5 IL13
17 chromium allergic contact dermatitis 10.2 IL5 IL13
18 ceftriaxone allergy 10.2 IL5 IL13
19 respiratory syncytial virus infectious disease 10.2 IL5 IL13
20 orange allergy 10.2 IL5 IL13
21 eosinophilic gastroenteritis 10.2 IL5 IL33
22 loiasis 10.2 IL5 IL13
23 mikulicz disease 10.2 IL5 IL13
24 nut allergy 10.2 IL5 IL13
25 pemphigoid 10.2 IL5 IL13
26 trichinosis 10.2 IL5 IL13
27 kimura disease 10.2 IL5 IL13
28 timothy grass allergy 10.2 IL5 IL13
29 nickel allergic contact dermatitis 10.2 IL5 IL13
30 vernal keratoconjunctivitis 10.2 IL5 IL13
31 keratoconjunctivitis 10.2 IL5 IL13
32 mite infestation 10.2 IL5 IL13
33 paragonimiasis 10.2 IL5 IL13
34 intrinsic asthma 10.2 IL5 IL13
35 vasomotor rhinitis 10.2 IL5 IL13
36 chronic meningitis 10.2 IL5 IL13
37 angiostrongyliasis 10.2 IL5 IL13
38 mucocutaneous leishmaniasis 10.2 IL5 IL13
39 elephantiasis 10.2 IL5 IL13
40 taeniasis 10.2 IL5 IL13
41 cardiomyopathy, familial hypertrophic, 20 10.2 IL5 IL13
42 egg allergy 10.1 IL5 IL13
43 filarial elephantiasis 10.1 IL5 IL13
44 strongyloidiasis 10.1 IL5 IL13
45 eosinophilic meningitis 10.1 IL5 IL13
46 drug allergy 10.1 IL5 IL13
47 urinary schistosomiasis 10.1 IL5 IL13
48 latex allergy 10.1 IL5 IL13
49 intestinal schistosomiasis 10.1 IL5 IL13
50 pollen allergy 10.1 IL5 IL13

Graphical network of the top 20 diseases related to Loeffler Syndrome:



Diseases related to Loeffler Syndrome
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Symptoms & Phenotypes for Loeffler Syndrome

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UMLS symptoms related to Loeffler Syndrome:


coughing

MGI Mouse Phenotypes related to Loeffler Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CCR3 IL13 IL18BP IL18RAP IL1RL1 IL33
2 digestive/alimentary MP:0005381 9.65 IL13 IL33 IL5 RAG2 SIGIRR
3 immune system MP:0005387 9.61 CCR3 IL13 IL18BP IL18RAP IL1RL1 IL33
4 respiratory system MP:0005388 9.02 CCR3 IL13 IL33 IL5 RAG2
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Drugs & Therapeutics for Loeffler Syndrome

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Search Clinical Trials , NIH Clinical Center for Loeffler Syndrome

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Genetic Tests for Loeffler Syndrome

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Anatomical Context for Loeffler Syndrome

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Publications for Loeffler Syndrome

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Articles related to Loeffler Syndrome:

(show all 46)
# Title Authors PMID Year
1
Chest CT Diagnosis and Clinical Management of Drug-Related Pneumonitis in Patients Receiving Molecular Targeting Agents and Immune Checkpoint Inhibitors: A Position Paper From the Fleischner Society. 61
33450293 2021
2
Chest CT Diagnosis and Clinical Management of Drug-related Pneumonitis in Patients Receiving Molecular Targeting Agents and Immune Checkpoint Inhibitors: A Position Paper from the Fleischner Society. 61
33434111 2021
3
Diagnosis of EGPA Syndrome in a Patient With Chronic Polypoid Rhinosinusitis Presenting as Loeffler Syndrome. 61
31565994 2019
4
Molecular Confirmation of Ascaris suum: Further Investigation into the Zoonotic Origin of Infection in an 8-Year-Old Boy with Loeffler Syndrome. 61
30085905 2018
5
Cardiopulmonary and Gastrointestinal Manifestations of Eosinophil- associated Diseases and Idiopathic Hypereosinophilic Syndromes: Multimodality Imaging Approach. 61
26963455 2016
6
Loeffler's syndrome: an interesting case report. 61
24931460 2016
7
Eosinophilic Lung Disease: Accompanied with 12 Cases. 61
29404099 2015
8
[A clinical analysis of twenty-five cases of eosinophilic lung disease]. 61
26080822 2015
9
Simple pulmonary eosinophilia associated with clozapine treatment. 61
25514065 2015
10
Simple pulmonary eosinophilia found on follow-up computed tomography of oncologic patients. 61
25082475 2014
11
[Travel-associated pneumonias]. 61
25290923 2014
12
[Strongyloidosis caused Loeffler's syndrome in an immunosuppressed patient who uses cronic steroid]. 61
23619049 2013
13
Pulmonary eosinophilic infiltrates. 61
21428117 2010
14
Pulmonary eosinophilia. 61
19618037 2009
15
Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview. 61
17495282 2007
16
[Malabsorption syndrome due to Strongyloides stercoralis associated with Loeffler syndrome in a 29-year-old woman]. 61
16790183 2006
17
Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases. 61
16374077 2005
18
[Loeffler syndrome and Mycoplasma pneumonitis. A case report]. 61
12070484 2002
19
[Tropical endomyocardial fibrosis or Davies disease. A case report]. 61
11181314 2001
20
Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients. 61
10966710 2000
21
[A mild case of acute eosinophilic pneumonia]. 61
9866986 1998
22
The spectrum of eosinophilic lung disease: radiologic findings. 61
9386285 1997
23
Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose. 61
8520792 1995
24
[Löffler's syndrome (simple pulmonary eosinophilia)]. 61
8152008 1994
25
[Pulmonary eosinophilia]. 61
8492456 1993
26
[A case of extrinsic allergic alveolitis in a shoe factory worker]. 61
1478527 1992
27
[Loeffler syndrome in a child treated with aspirin]. 61
2344984 1990
28
[A rare case of the meningoencephalitis form of the Loeffler syndrome]. 61
3577504 1987
29
Loeffler's syndrome: an uncommon adverse reaction to imipramine. 61
3559155 1986
30
[Eosinophilic pulmonary infiltrate (considerations of a case of Loeffler syndrome)]. 61
6296981 1982
31
[Pneumonitis with eosinophilia; Loeffler syndrome]. 61
13554102 1957
32
[Endemic of the so-called Loeffler syndrome]. 61
12993072 1952
33
[Loeffler syndrome]. 61
13012690 1952
34
[Transitory pulmonary opacities; Loeffler syndrome and so-called Fanconi-Hegglin pseudosyphilitic bronchopneumonia]. 61
14953111 1952
35
[A case of Loeffler syndrome]. 61
14807587 1950
36
A Loeffler Syndrome Case 61
18148173 1949
37
On a case of Loeffler syndrome with six subsequent lung infiltrates. 61
18136410 1949
38
Multinodular and hemoptotic loeffler syndrome of ascarid origin. 61
18894199 1948
39
On two cases of eosinophilic fleeting lung infiltrate; Loeffler syndrome. 61
18888570 1948
40
Loeffler syndrome. 61
18860621 1947
41
Loeffler syndrome allergy reaction in a carrier of whipworms. 61
20269524 1947
42
Parinaud conjunctivitis and Loeffler syndrome. 61
20344193 1947
43
Loeffler syndrome in micronodular form in an asthmatic. 61
21019634 1946
44
Loeffler syndrome. 61
21016087 1945
45
Fugitive pulmonary infiltrations with blood eosinophilia (ie Loeffler syndrome). 61
21012089 1945
46
Loeffler syndrome. 61
20984013 1945
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Variations for Loeffler Syndrome

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Expression for Loeffler Syndrome

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Search GEO for disease gene expression data for Loeffler Syndrome.
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Pathways for Loeffler Syndrome

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Pathways related to Loeffler Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.6 SIGIRR RAG2 IL5 IL33 IL1RL1 IL18RAP
2
PEDF Induced Signaling 63
Show member pathways
 13.33 IL5 IL33 IL1RL1 IL18RAP IL13 CCR3
3
Cytokine Signaling in Immune system 65
Show member pathways
 12.81 RAG2 IL5 IL33 IL1RL1 IL18RAP IL18BP
4
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.35 SIGIRR IL33 IL1RL1 IL18RAP IL18BP
5
Lung fibrosis 1
11.34 IL5 IL13 CCR3
6
Innate Lymphoid Cell Differentiation Pathways 64
11.16 IL5 IL33 IL1RL1 IL13
7
Cytokines and Inflammatory Response 1
10.99 IL5 IL13
8
IL12 signaling mediated by STAT4 1
10.94 IL18RAP IL13
9
Development and heterogeneity of the ILC family 1
10.94 IL5 IL33 IL13
10
IL1 Signaling Pathway 66
10.91 IL33 IL18RAP
11
OX40 Pathway 63
10.87 IL5 IL13
12
Th2 Differentiation Pathway 64
10.59 IL5 IL33 IL1RL1 IL13
13
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.51 IL5 IL13
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GO Terms for Loeffler Syndrome

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Biological processes related to Loeffler Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.76 IL5 IL18RAP IL13 CCR3
2 immune response GO:0006955 9.72 IL5 IL1RL1 IL18RAP IL13 CCR3
3 cytokine-mediated signaling pathway GO:0019221 9.7 IL5 IL1RL1 IL13
4 negative regulation of interferon-gamma production GO:0032689 9.51 IL33 IL1RL1
5 positive regulation of B cell proliferation GO:0030890 9.49 IL5 IL13
6 positive regulation of chemokine production GO:0032722 9.48 IL33 IL1RL1
7 positive regulation of interleukin-5 production GO:0032754 9.43 IL33 IL1RL1
8 interleukin-18-mediated signaling pathway GO:0035655 9.4 IL18RAP IL18BP
9 negative regulation of T-helper 1 type immune response GO:0002826 9.37 IL33 IL1RL1
10 positive regulation of macrophage activation GO:0043032 9.33 IL33 IL1RL1 IL13
11 interleukin-33-mediated signaling pathway GO:0038172 9.26 IL33 IL1RL1
12 positive regulation of immunoglobulin production GO:0002639 9.13 IL5 IL33 IL13
13 cellular response to cytokine stimulus GO:0071345 8.92 SIGIRR IL18RAP IL18BP IL13

Molecular functions related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 IL5 IL33 IL13
2 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 8.96 IL1RL1 IL18RAP
3 NAD(P)+ nucleosidase activity GO:0050135 8.62 IL1RL1 IL18RAP
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Sources for Loeffler Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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