Loeffler Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Loeffler Syndrome

MalaCards integrated aliases for Loeffler Syndrome:

Name: Loeffler Syndrome ¹¹ ¹⁴

Simple Pulmonary Eosinophilia ⁷¹

Loeffler's Pneumonia ¹¹

Loffler's Syndrome ¹¹

Classifications:

MalaCards categories:
Anatomical: Immune diseases Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:9503

MeSH ⁴³ D011657

NCIt ⁴⁹ C35301

SNOMED-CT ⁶⁸ 64936001

UMLS ⁷¹ C0242459

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Summaries for Loeffler Syndrome

Disease Ontology: ¹¹ An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection.

MalaCards based summary: Loeffler Syndrome, also known as simple pulmonary eosinophilia, is related to eosinophilic pneumonia and ascaris lumbricoides infection, and has symptoms including coughing An important gene associated with Loeffler Syndrome is IL33 (Interleukin 33), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include lung, and related phenotypes are immune system and respiratory system

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Related Diseases for Loeffler Syndrome

Diseases related to Loeffler Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)

#	Related Disease	Score	Top Affiliating Genes
1	eosinophilic pneumonia	30.0	IL5 IL13 FIP1L1
2	ascaris lumbricoides infection	30.0	STH IL5 IL13
3	common cold	30.0	IL5 IL33 IL13
4	bronchitis	29.8	IL5 IL13 CCR3
5	pulmonary eosinophilia	29.8	PRG2 IL5 IL13 CCR3
6	conjunctivitis	29.7	IL5 IL33 IL1RL1 IL13
7	churg-strauss syndrome	29.7	PRG2 IL5
8	strongyloidiasis	29.7	STH IL5 IL13
9	hypereosinophilic syndrome	29.6	PRG2 IL5 IL13 FIP1L1 CCR3
10	nut allergy	10.2	IL5 IL13
11	hypereosinophilic syndrome, idiopathic	10.2	IL5 FIP1L1
12	aztreonam allergy	10.2	IL5 IL13
13	nickel allergic contact dermatitis	10.2	IL5 IL13
14	chromium allergic contact dermatitis	10.2	IL5 IL13
15	cefaclor allergy	10.2	IL5 IL13
16	respiratory syncytial virus infectious disease	10.2	IL5 IL13
17	persistent severe asthma	10.2	IL5 IL13
18	disseminated eosinophilic collagen disease	10.2	IL5 FIP1L1
19	papillary conjunctivitis	10.2	IL5 IL13
20	mononeuritis multiplex	10.2	IL5 FIP1L1
21	cough variant asthma	10.2	IL5 IL13
22	norwegian scabies	10.2	IL5 IL13
23	aspirin-induced respiratory disease	10.2	IL5 IL13
24	cow milk allergy	10.2	IL5 IL13
25	milk allergy	10.2	IL5 IL13
26	angiostrongyliasis	10.2	IL5 IL13
27	eosinophilic meningitis	10.2	IL5 IL13
28	metal allergy	10.2	IL5 IL13
29	mikulicz disease	10.2	IL5 IL13
30	eosinophilia-myalgia syndrome	10.2	IL5 FIP1L1
31	esophageal candidiasis	10.2	IL5 IL13
32	trichinosis	10.2	IL5 IL13
33	vasomotor rhinitis	10.1	IL5 IL13
34	giant papillary conjunctivitis	10.1	IL5 IL13
35	chronic meningitis	10.1	IL5 IL13
36	mucocutaneous leishmaniasis	10.1	IL5 IL13
37	exercise-induced bronchoconstriction	10.1	IL5 IL13
38	pollen allergy	10.1	IL5 IL13
39	egg allergy	10.1	IL5 IL13
40	igg4-related disease	10.1	IL5 IL13
41	drug allergy	10.1	IL5 IL13
42	chronic eosinophilic leukemia	10.1	IL5 FIP1L1
43	nasopharyngitis	10.1	IL5 IL13
44	pneumothorax, primary spontaneous	10.1	LRRC43 IL33 IL1RL1
45	status asthmaticus	10.1	IL5 IL13
46	dermatitis	10.1	IL5 IL33 IL13
47	thunderstorm triggered asthma	10.1	IL5 IL33 IL13
48	near-fatal asthma	10.1	IL5 IL33 IL13
49	posterior uveitis	10.1	IL5 IL13
50	t2-low asthma	10.1	IL5 IL33 IL13

Graphical network of the top 20 diseases related to Loeffler Syndrome:

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Symptoms & Phenotypes for Loeffler Syndrome

UMLS symptoms related to Loeffler Syndrome:

coughing

MGI Mouse Phenotypes related to Loeffler Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.76	CCR3 IL13 IL1RL1 IL33 IL5 PRG2
2	respiratory system	MP:0005388	9.43	CCR3 IL13 IL33 IL5 PRG2 RAG2
3	hematopoietic system	MP:0005397	9.23	CCR3 IL13 IL1RL1 IL33 IL5 PRG2

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Drugs & Therapeutics for Loeffler Syndrome

Search Clinical Trials, NIH Clinical Center for Loeffler Syndrome

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Genetic Tests for Loeffler Syndrome

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Anatomical Context for Loeffler Syndrome

Organs/tissues related to Loeffler Syndrome:

MalaCards : Lung

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Publications for Loeffler Syndrome

Articles related to Loeffler Syndrome:

(show all 46)

#	Title	Authors	PMID	Year
1	Pregnant lady with eosinophilia: common cause, uncommon association. ⁶²	Tyagi R...Srinivas S	35035052	2022
2	Loeffler's syndrome in a child: A rare radiological and histopathological diagnosis. ⁶²	Tran KH...Dang CT	34840639	2022
3	Diagnosis of EGPA Syndrome in a Patient With Chronic Polypoid Rhinosinusitis Presenting as Loeffler Syndrome. ⁶²	Bianco MR...Allegra E	31565994	2021
4	Rare presentation of haemobilia and Loeffler's pneumonia in a child by ascaris lumbricoides. ⁶²	Cheema HA...Saeed A	31466983	2019
5	Molecular Confirmation of Ascaris suum: Further Investigation into the Zoonotic Origin of Infection in an 8-Year-Old Boy with Loeffler Syndrome. ⁶²	Avery RH...Malone JB	30085905	2018
6	Loeffler's syndrome: an interesting case report. ⁶²	Ekin S...Yildiz H	24931460	2016
7	[Travel-associated pneumonias]. ⁶²	Geerdes-Fenge HF	25290923	2014
8	[Loeffler's syndrome mimicking bronchial asthma and pneumonia in a child: case report]. ⁶²	Deveci U...Aydin M	24412873	2013
9	[Strongyloidosis caused Loeffler's syndrome in an immunosuppressed patient who uses cronic steroid]. ⁶²	Ekmekci OO...Oner YA	23619049	2013
10	[Malabsorption syndrome due to Strongyloides stercoralis associated with Loeffler syndrome in a 29-year-old woman]. ⁶²	Velasco A...Rodriguez A	16790183	2006
11	Loffler's syndrome associated with Clonorchis sinensis infestation. ⁶²	Lee HK...Yum HK	14717238	2003
12	[Loeffler syndrome and Mycoplasma pneumonitis. A case report]. ⁶²	Celandroni A...Caprai S	12070484	2002
13	[Tropical endomyocardial fibrosis or Davies disease. A case report]. ⁶²	Fernandez FJ...Lezaun R	11181314	2001
14	Ascariasis and hookworm. ⁶²	Sarinas PS...Chitkara RK	9195678	1997
15	[Chronic course of eosinophilic pneumonia in infection with ascaris lumbricoides]. ⁶²	Rexroth G...Keller C	7724507	1995
16	[A case of extrinsic allergic alveolitis in a shoe factory worker]. ⁶²	Poliakova IN	1478527	1992
17	[Loeffler syndrome in a child treated with aspirin]. ⁶²	Sandhaus Y...Schreiber M	2344984	1990
18	[A rare case of the meningoencephalitis form of the Loeffler syndrome]. ⁶²	Ambalov IuM...Mzokova VM	3577504	1987
19	Nonspecific allergic granulomatosis in the lungs of mice infected with large but not small inocula of the canine ascarid, Toxocara canis. ⁶²	Kayes SG	3742887	1986
20	[Eosinophilic pulmonary infiltrate (considerations of a case of Loeffler syndrome)]. ⁶²	Herman PO	6296981	1982
21	Ultrastructure of the lung in Loeffler's pneumonia. ⁶²	Bedrossian CW...Williams LJ	1115077	1975
22	Loffler's syndrome. Report of a case associated with the administration of aurothioglucose (Solganal). ⁶²	GARRELL M	13703724	1960
23	Loffler's syndrome: report of a case associated with administration of mephenesin carbamate (tolseram). ⁶²	RODMAN T...MYERSON RM	13521594	1958
24	[Pneumonitis with eosinophilia; Loeffler syndrome]. ⁶²	DE MORO ER...LISTA GA	13554102	1957
25	[Parietal fibroplastic endocarditis with blood eosinophilia (Loffler's syndrome) and its relation to parietal endocardial fibroses]. ⁶²	WEISS-CARMINE S	13454776	1957
26	Loeffler's pneumonia associated with hypogammaglobulinemia. ⁶²	AZIZA C...LAPIN JH	13406682	1957
27	[Endemic of the so-called Loeffler syndrome]. ⁶²	TRUTSCHEL W	12993072	1952
28	[Loeffler syndrome]. ⁶²	DE VASCONCELOS M	13012690	1952
29	[A case of transient pulmonary eosinophilia (Loffler's syndrome)]. ⁶²	MOGIELNICKI S	13026548	1952
30	Loffler's syndrome probably due to sulphanilamide medication; case report. ⁶²	HOWARD DL...BELL TA	14942891	1952
31	[Transitory pulmonary opacities; Loeffler syndrome and so-called Fanconi-Hegglin pseudosyphilitic bronchopneumonia]. ⁶²	MINCUZZI G...SALVATI G	14953111	1952
32	Loffler's syndrome; report of cases in twins. ⁶²	SHECHTER FR...GRAUB M	14850314	1951
33	[A case of Loeffler syndrome]. ⁶²	DURIO A...PESCHLE B	14807587	1950
34	A Loeffler Syndrome Case ⁶²	BEAUCHANT...DEMIOT	18148173	1949
35	On a case of Loeffler syndrome with six subsequent lung infiltrates. ⁶²	CAVALLERI A	18136410	1949
36	Multinodular and hemoptotic loeffler syndrome of ascarid origin. ⁶²	BOUCHER H...LAFUMA J	18894199	1948
37	Loffler's syndrome. ⁶²	DALLAS HF	18879475	1948
38	On the pathogenesis and etiology of volatile lung infiltrates with blood eosinophilia (Loffler's syndrome). ⁶²	LOFFLER W...MACEDO ME	18879263	1948
39	On two cases of eosinophilic fleeting lung infiltrate; Loeffler syndrome. ⁶²	LAVERDA F	18888570	1948
40	Loeffler syndrome. ⁶²	LOURD L	18860621	1947
41	Loeffler syndrome allergy reaction in a carrier of whipworms. ⁶²	CAMELIN...GARNUNG	20269524	1947
42	Parinaud conjunctivitis and Loeffler syndrome. ⁶²	BOURQUIN JB	20344193	1947
43	Loeffler syndrome in micronodular form in an asthmatic. ⁶²	SIMONIN P...GIRARD J	21019634	1946
44	Loeffler syndrome. ⁶²	TRANCHESI B...COMENALE JUNIOR C	21016087	1945
45	Fugitive pulmonary infiltrations with blood eosinophilia (ie Loeffler syndrome). ⁶²	LOEFFLER W	21012089	1945
46	Loeffler syndrome. ⁶²	ROCH	20984013	1945

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Genes for Loeffler Syndrome

Genes related to Loeffler Syndrome (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IL33	Interleukin 33	Protein Coding	5.09	DISEASES inferred ¹⁴
2	IL5	Interleukin 5	Protein Coding	4.97	DISEASES inferred ¹⁴
3	LRRC43	Leucine Rich Repeat Containing 43	Protein Coding	4.78	DISEASES inferred ¹⁴
4	IL1RL1	Interleukin 1 Receptor Like 1	Protein Coding	4.71	DISEASES inferred ¹⁴
5	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	4.65	DISEASES inferred ¹⁴
6	IL13	Interleukin 13	Protein Coding	4.6	DISEASES inferred ¹⁴
7	SIGIRR	Single Ig And TIR Domain Containing	Protein Coding	4.47	DISEASES inferred ¹⁴
8	PRG2	Proteoglycan 2, Pro Eosinophil Major Basic Protein	Protein Coding	4.33	DISEASES inferred ¹⁴
9	STH	Saitohin	Protein Coding	4.29	DISEASES inferred ¹⁴
10	RAG2	Recombination Activating 2	Protein Coding	4.28	DISEASES inferred ¹⁴
11	CCR3	C-C Motif Chemokine Receptor 3	Protein Coding	4.11	DISEASES inferred ¹⁴

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Variations for Loeffler Syndrome

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Expression for Loeffler Syndrome

Search GEO for disease gene expression data for Loeffler Syndrome.

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Pathways for Loeffler Syndrome

Pathways related to Loeffler Syndrome according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.59	SIGIRR RAG2 PRG2 IL5 IL33 IL1RL1
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.88	SIGIRR RAG2 IL5 IL33 IL1RL1 IL13
3	Interleukin-1 family signaling ⁶⁶ Show member pathways Interleukin-1 signaling ⁶⁶ Interleukin-18 signaling ⁶⁶ Interleukin-38 signaling ⁶⁶	12.12	SIGIRR IL33 IL1RL1 IL13
4	Lung fibrosis ⁷⁴	11.23	IL5 IL13 CCR3
5	Innate Lymphoid Cells Differentiation ⁶⁵	11.16	IL5 IL33 IL1RL1 IL13
6	Cytokines and inflammatory response ⁷⁴	10.94	IL5 IL13
7	Immune infiltration in pancreatic cancer ⁷⁴	10.89	IL5 IL13
8	OX40 Pathway ⁶⁴	10.85	IL5 IL13
9	Development and heterogeneity of the ILC family ⁷⁴	10.84	IL5 IL33 IL13
10	Th2 Differentiation ⁶⁵	10.59	IL5 IL33 IL1RL1 IL13
11	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.48	IL5 IL13

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GO Terms for Loeffler Syndrome

Biological processes related to Loeffler Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10.02	PRG2 IL5 IL1RL1 IL13 CCR3
2	positive regulation of interleukin-4 production	GO:0032753	9.71	PRG2 IL33
3	positive regulation of interleukin-5 production	GO:0032754	9.67	IL33 IL1RL1
4	negative regulation of T-helper 1 type immune response	GO:0002826	9.56	IL33 IL1RL1
5	interleukin-33-mediated signaling pathway	GO:0038172	9.46	IL33 IL1RL1
6	positive regulation of immunoglobulin production	GO:0002639	9.43	IL5 IL33 IL13
7	positive regulation of macrophage activation	GO:0043032	9.1	IL33 IL1RL1 IL13

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Sources for Loeffler Syndrome

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LFF002 MIFTS: 29	Loeffler Syndrome Categories: Immune diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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