MCID: LFF002
MIFTS: 25

Loeffler Syndrome

Categories: Blood diseases, Respiratory diseases

Aliases & Classifications for Loeffler Syndrome

MalaCards integrated aliases for Loeffler Syndrome:

Name: Loeffler Syndrome 12 15
Simple Pulmonary Eosinophilia 74
Loeffler's Pneumonia 12
Loffler's Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9503
MeSH 45 D011657
NCIt 51 C35301
SNOMED-CT 69 64936001
ICD10 34 J82
UMLS 74 C0242459

Summaries for Loeffler Syndrome

Disease Ontology : 12 An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection.

MalaCards based summary : Loeffler Syndrome, also known as simple pulmonary eosinophilia, is related to eosinophilic pneumonia and agammaglobulinemia, and has symptoms including coughing An important gene associated with Loeffler Syndrome is ACE (Angiotensin I Converting Enzyme). The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include lung, skin and kidney.

Wikipedia : 77 Löffler''s syndrome is a disease in which eosinophils accumulate in the lung in response to a parasitic... more...

Related Diseases for Loeffler Syndrome

Diseases related to Loeffler Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 eosinophilic pneumonia 11.1
2 agammaglobulinemia 10.0
3 pneumonia 10.0
4 orthostatic proteinuria 9.9 ACE ALB
5 hypertensive nephropathy 9.9 ACE ALB
6 syndrome of inappropriate antidiuretic hormone 9.9 ACE ALB
7 microvascular complications of diabetes 3 9.9 ACE ALB
8 anuria 9.9 ACE ALB
9 hepatorenal syndrome 9.9 ACE ALB
10 renal hypertension 9.9 ACE ALB
11 intermittent claudication 9.9 ACE ALB
12 pyelonephritis 9.9 ACE ALB
13 interstitial nephritis 9.9 ACE ALB
14 obstructive nephropathy 9.9 ACE ALB
15 coronary stenosis 9.9 ACE ALB
16 retinal vascular disease 9.9 ACE ALB
17 vascular disease 9.9 ACE ALB
18 iga glomerulonephritis 9.9 ACE ALB
19 peripheral vascular disease 9.9 ACE ALB
20 end stage renal failure 9.9 ACE ALB
21 microvascular complications of diabetes 5 9.9 ACE ALB
22 arteries, anomalies of 9.9 ACE ALB
23 glucose metabolism disease 9.9 ACE ALB
24 membranous nephropathy 9.9 ACE ALB
25 urinary system disease 9.9 ACE ALB
26 acquired metabolic disease 9.9 ACE ALB
27 respiratory failure 9.8 ACE ALB
28 cardiac arrest 9.8 ACE ALB
29 nervous system disease 9.8 ACE ALB
30 autosomal dominant polycystic kidney disease 9.8 ACE ALB
31 kidney disease 9.8 ACE ALB
32 maturity-onset diabetes of the young, type 1 9.8 ACE ALB
33 diabetes mellitus, insulin-dependent 9.8 ACE ALB
34 diabetes mellitus 9.8 ACE ALB
35 chronic kidney failure 9.8 ACE ALB
36 focal segmental glomerulosclerosis 9.8 ACE ALB
37 hypertension, essential 9.7 ACE ALB
38 heart disease 9.7 ACE ALB
39 myocardial infarction 9.7 ACE ALB
40 diabetes mellitus, noninsulin-dependent 9.6 ACE ALB
41 dilated cardiomyopathy 9.5 ACE ALB

Graphical network of the top 20 diseases related to Loeffler Syndrome:



Diseases related to Loeffler Syndrome

Symptoms & Phenotypes for Loeffler Syndrome

UMLS symptoms related to Loeffler Syndrome:


coughing

Drugs & Therapeutics for Loeffler Syndrome

Drugs for Loeffler Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved 10102-43-9 145068

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Usefulness of Exhaled NO in the Differential Diagnosis Acute Eosinophilic Pneumonia and Bacterial Pneumonia Unknown status NCT01152424

Search NIH Clinical Center for Loeffler Syndrome

Genetic Tests for Loeffler Syndrome

Anatomical Context for Loeffler Syndrome

MalaCards organs/tissues related to Loeffler Syndrome:

42
Lung, Skin, Kidney, Heart

Publications for Loeffler Syndrome

Articles related to Loeffler Syndrome:

# Title Authors Year
1
Molecular Confirmation of Ascaris suum: Further Investigation into the Zoonotic Origin of Infection in an 8-Year-Old Boy with Loeffler Syndrome. ( 30085905 )
2018
2
Eosinophilic leukemoid reaction in a male adolescent with Löeffler syndrome. ( 26628768 )
2015
3
Simple pulmonary eosinophilia associated with clozapine treatment. ( 25514065 )
2015
4
Simple pulmonary eosinophilia found on follow-up computed tomography of oncologic patients. ( 25082475 )
2014
5
Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases. ( 16374077 )
2005

Variations for Loeffler Syndrome

Expression for Loeffler Syndrome

Search GEO for disease gene expression data for Loeffler Syndrome.

Pathways for Loeffler Syndrome

GO Terms for Loeffler Syndrome

Molecular functions related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 8.62 ACE ALB

Sources for Loeffler Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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