MCID: LFF002
MIFTS: 22

Loeffler Syndrome

Categories: Blood diseases, Respiratory diseases

Aliases & Classifications for Loeffler Syndrome

MalaCards integrated aliases for Loeffler Syndrome:

Name: Loeffler Syndrome 12 15
Simple Pulmonary Eosinophilia 73
Loeffler's Pneumonia 12
Loffler's Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9503
ICD10 33 J82
MeSH 44 D011657
NCIt 50 C35301
SNOMED-CT 68 64936001
UMLS 73 C0242459

Summaries for Loeffler Syndrome

Disease Ontology : 12 An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection.

MalaCards based summary : Loeffler Syndrome, also known as simple pulmonary eosinophilia, is related to eosinophilic pneumonia and uveoparotid fever, and has symptoms including coughing An important gene associated with Loeffler Syndrome is ACE (Angiotensin I Converting Enzyme). The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include kidney.

Related Diseases for Loeffler Syndrome

Diseases related to Loeffler Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 eosinophilic pneumonia 11.1
2 uveoparotid fever 10.0 ACE ENSG00000264813
3 autoimmune atherosclerosis 10.0 ACE ENSG00000264813
4 fiedler's myocarditis 10.0 ACE ENSG00000264813
5 malignant essential hypertension 10.0 ACE ENSG00000264813
6 subdural empyema 10.0 ACE ENSG00000264813
7 hypersensitivity reaction type iv disease 10.0 ACE ENSG00000264813
8 aortic valve disease 1 9.9 ACE ENSG00000264813
9 hypertensive nephropathy 9.9 ACE ALB
10 syndrome of inappropriate antidiuretic hormone 9.9 ACE ALB
11 microvascular complications of diabetes 3 9.9 ACE ALB
12 anuria 9.9 ACE ALB
13 hepatorenal syndrome 9.9 ACE ALB
14 renal hypertension 9.9 ACE ALB
15 intermittent claudication 9.9 ACE ALB
16 pyelonephritis 9.9 ACE ALB
17 interstitial nephritis 9.9 ACE ALB
18 obstructive nephropathy 9.9 ACE ALB
19 coronary stenosis 9.9 ACE ALB
20 retinal vascular disease 9.9 ACE ALB
21 vascular disease 9.9 ACE ALB
22 iga glomerulonephritis 9.9 ACE ALB
23 peripheral vascular disease 9.9 ACE ALB
24 end stage renal failure 9.9 ACE ALB
25 microvascular complications of diabetes 5 9.8 ACE ALB
26 immune system disease 9.8 ACE ALB
27 membranous nephropathy 9.8 ACE ALB
28 respiratory failure 9.8 ACE ALB
29 cardiac arrest 9.8 ACE ALB
30 autosomal dominant polycystic kidney disease 9.8 ACE ALB
31 nervous system disease 9.8 ACE ALB
32 chronic kidney failure 9.8 ACE ALB
33 orthostatic proteinuria 9.7 ACE ALB ENSG00000264813
34 arteries, anomalies of 9.7 ACE ALB ENSG00000264813
35 glucose metabolism disease 9.7 ACE ALB ENSG00000264813
36 focal segmental glomerulosclerosis 9.7 ACE ALB
37 urinary system disease 9.7 ACE ALB ENSG00000264813
38 acquired metabolic disease 9.7 ACE ALB ENSG00000264813
39 maturity-onset diabetes of the young, type 1 9.7 ACE ALB ENSG00000264813
40 hypertension, essential 9.7 ACE ALB ENSG00000264813
41 diabetes mellitus, insulin-dependent 9.6 ACE ALB

Graphical network of the top 20 diseases related to Loeffler Syndrome:



Diseases related to Loeffler Syndrome

Symptoms & Phenotypes for Loeffler Syndrome

UMLS symptoms related to Loeffler Syndrome:


coughing

Drugs & Therapeutics for Loeffler Syndrome

Drugs for Loeffler Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved 10102-43-9 145068

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Usefulness of Exhaled NO in the Differential Diagnosis Acute Eosinophilic Pneumonia and Bacterial Pneumonia Unknown status NCT01152424

Search NIH Clinical Center for Loeffler Syndrome

Genetic Tests for Loeffler Syndrome

Anatomical Context for Loeffler Syndrome

MalaCards organs/tissues related to Loeffler Syndrome:

41
Kidney

Publications for Loeffler Syndrome

Articles related to Loeffler Syndrome:

# Title Authors Year
1
Molecular Confirmation of Ascaris suum: Further Investigation into the Zoonotic Origin of Infection in an 8-Year-Old Boy with Loeffler Syndrome. ( 30085905 )
2018

Variations for Loeffler Syndrome

Expression for Loeffler Syndrome

Search GEO for disease gene expression data for Loeffler Syndrome.

Pathways for Loeffler Syndrome

GO Terms for Loeffler Syndrome

Cellular components related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 ACE ALB ENSG00000264813

Biological processes related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of blood pressure GO:0045777 8.96 ACE ENSG00000264813
2 positive regulation of systemic arterial blood pressure GO:0003084 8.62 ACE ENSG00000264813

Molecular functions related to Loeffler Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.37 ACE ENSG00000264813
2 drug binding GO:0008144 9.32 ACE ALB
3 carboxypeptidase activity GO:0004180 9.26 ACE ENSG00000264813
4 dipeptidyl-peptidase activity GO:0008239 9.16 ACE ENSG00000264813
5 exopeptidase activity GO:0008238 8.96 ACE ENSG00000264813
6 peptidyl-dipeptidase activity GO:0008241 8.62 ACE ENSG00000264813

Sources for Loeffler Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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