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MCID: LSS001
MIFTS: 36

Loiasis

Categories: Eye diseases, Infectious diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Loiasis

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MalaCards integrated aliases for Loiasis:

Name: Loiasis 12 76 53 59 3 44 15
Loa Loa Filariasis 53
African Eye Worm 53

Characteristics:

Orphanet epidemiological data:

59
loiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Skin diseases Eye diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13523
ICD10 33 B74.3
ICD9CM 35 125.2
MeSH 44 D008118
NCIt 50 C34784
SNOMED-CT 68 44250009
Orphanet 59 ORPHA2404
MESH via Orphanet 45 D008118
UMLS via Orphanet 74 C0023968
ICD10 via Orphanet 34 B74.3
UMLS 73 C0023968
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Summaries for Loiasis

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CDC : 3 Loiasis, called African eye worm by most people, is caused by the parasitic worm Loa loa. It is passed on to humans through the repeated bites of deerflies (also known as mango flies or mangrove flies) of the genus Chrysops. The flies that pass on the parasite breed in certain rain forests of West and Central Africa. Infection with the parasite can also cause repeated episodes of itchy swellings of the body known as Calabar swellings. Knowing whether someone has a Loa loa infection has become more important in Africa because the presence of people with Loa loa infection has limited programs to control or eliminate onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis). There may be more than 29 million people who are at risk of getting loaisis in affected areas of Central and West Africa.

MalaCards based summary : Loiasis, also known as loa loa filariasis, is related to filarial elephantiasis and onchocerciasis. An important gene associated with Loiasis is IL10 (Interleukin 10). The drugs Diethylcarbamazine and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and spleen.

Disease Ontology : 12 A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

Wikipedia : 76 Loa loa filariasis is a skin and eye disease caused by the nematode worm Loa loa. Humans contract this... more...

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Related Diseases for Loiasis

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Diseases related to Loiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 filarial elephantiasis 30.3 IL10 SRCIN1
2 onchocerciasis 10.5
3 thrombosis 10.3
4 filariasis 10.3
5 schistosomiasis 10.1
6 encephalitis 10.1
7 sclerosing keratitis 10.0 MFF SRCIN1
8 deep keratitis 10.0 MFF SRCIN1
9 elephantiasis 10.0 MFF SRCIN1
10 glomerulonephritis 9.9
11 lymphoma 9.9
12 trypanosomiasis 9.9
13 nephrotic syndrome 9.9
14 retinal artery occlusion 9.9
15 lymphosarcoma 9.9
16 acanthocheilonemiasis 9.9
17 encephalopathy 9.9
18 anterior scleritis 9.9 MFF SRCIN1
19 commensal bacterial infectious disease 9.9 IL10 PHB2
20 parasitic helminthiasis infectious disease 9.8 IL10 MFF SRCIN1
21 bone inflammation disease 9.8 IL10 PHB2

Graphical network of the top 20 diseases related to Loiasis:



Diseases related to Loiasis
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Symptoms & Phenotypes for Loiasis

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Drugs & Therapeutics for Loiasis

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Drugs for Loiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 90-89-1 3052
2
Ivermectin Approved, Investigational, Vet_approved Phase 4,Not Applicable 70288-86-7 6474909
3 Lipoxygenase Inhibitors Phase 4,Phase 2,Not Applicable
4 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
5 Antiparasitic Agents Phase 4,Phase 2,Not Applicable
6 Anthelmintics Phase 4,Phase 2,Not Applicable
7 Reslizumab Approved, Investigational Phase 2
8 Anti-Asthmatic Agents Phase 2
9 Antibodies, Monoclonal Phase 2
10 Antibodies Phase 2
11 Respiratory System Agents Phase 2
12 Immunoglobulins Phase 2
13
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
14
Suramin Investigational 145-63-1 5361
15 Antiprotozoal Agents Not Applicable
16 Antimitotic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Completed NCT01593722 Phase 4 Diethylcarbamazine;Ivermectin
2 Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Completed NCT01111305 Phase 2 Reslizumab;Diethylcarbamazine
3 Impact of Educational and Professional Supportive Interventions on Nursing Home Quality Indicators Completed NCT01703689 Not Applicable
4 Host Response to Infection and Treatment in Filarial Diseases Recruiting NCT00001230
5 Lymphatic Filariasis (LF) in Ivory Coast Active, not recruiting NCT02974049 Not Applicable Albendazole;Ivermectin;Diethylcarbamazine

Search NIH Clinical Center for Loiasis

Cochrane evidence based reviews: loiasis

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Genetic Tests for Loiasis

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Anatomical Context for Loiasis

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MalaCards organs/tissues related to Loiasis:

41
Eye, Skin, Spleen, T Cells, Liver, Bone, Breast
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Publications for Loiasis

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Articles related to Loiasis:

(show top 50) (show all 171)
# Title Authors Year
1
In Southern Nigeria <i>Loa loa</i> Blood Microfilaria Density is Very Low Even in Areas with High Prevalence of Loiasis: Results of a Survey Using the New LoaScope Technology. ( 29761763 )
2018
2
Integrated risk mapping and landscape characterisation of lymphatic filariasis and loiasis in South West Nigeria. ( 29774296 )
2018
3
Case Report: Probable Case of Spontaneous Encephalopathy Due to Loiasis and Dramatic Reduction of <i>Loa loa</i> Microfilariaemia with Prolonged Repeated Courses of Albendazole. ( 29741149 )
2018
4
Behavioural and clinical predictors for Loiasis. ( 29497506 )
2018
5
Impact of repeated annual community directed treatment with ivermectin on loiasis parasitological indicators in Cameroon: Implications for onchocerciasis and lymphatic filariasis elimination in areas co-endemic with Loa loa in Africa. ( 30226900 )
2018
6
Comparison of different drug regimens for the treatment of loiasis-A TropNet retrospective study. ( 30383753 )
2018
7
Loiasis in US Traveler Returning from Bioko Island, Equatorial Guinea, 2016. ( 27983940 )
2017
8
Encephalitis secondary to diethylcarbamazine treatment in a patient with ocular loiasis. ( 28579217 )
2017
9
Ocular loiasis in Ohio: a case report. ( 28756499 )
2017
10
Excess mortality associated with loiasis: a retrospective population-based cohort study. ( 27777031 )
2017
11
Loiasis, a Subconjunctival Manifestation. ( 28595769 )
2017
12
Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis. ( 27806050 )
2016
13
Therapeutic apheresis using a mononuclear cell program to lower the microfilaria burden of a 23-year-old African woman with loiasis. ( 27302472 )
2016
14
Calcification of the breasts due to loiasis. ( 27051574 )
2016
15
Clinical Features of Imported Loiasis: A Case Series from the Hospital for Tropical Diseases, London. ( 26101271 )
2015
16
Co-endemicity of Loiasis and Onchocerciasis in Rain Forest Communities in Southwestern Nigeria. ( 25812086 )
2015
17
Loiasis in a Japanese Traveler Returning from Central Africa. ( 26161033 )
2015
18
The relationship between microfilaraemic and amicrofilaraemic loiasis involving co-infection with Mansonella perstans and clinical symptoms in an exposed population from Gabon. ( 26268068 )
2015
19
Parasitological, Hematological and Biochemical Characteristics of a Model of Hyper-microfilariaemic Loiasis (Loa loa) in the Baboon (Papio anubis). ( 26555070 )
2015
20
Chronic symptomatic and microfilaremic loiasis in a returned traveller. ( 25561630 )
2015
21
Eosinophil-Associated Processes Underlie Differences in Clinical Presentation of Loiasis Between Temporary Residents and Those Indigenous to Loa-Endemic Areas. ( 25234520 )
2014
22
Imported loiasis in Italy: An analysis of 100 cases. ( 25131142 )
2014
23
Single molecule sequencing and genome assembly of a clinical specimen of Loa loa, the causative agent of loiasis. ( 25217238 )
2014
24
Non-ophthalmological presentation of imported loiasis. ( 24857349 )
2014
25
Impact of repeated ivermectin treatments against onchocerciasis on the transmission of loiasis: an entomologic evaluation in central Cameroon. ( 24289520 )
2013
26
Ocular loiasis in a patient with chronic hypereosinophilia. ( 24269453 )
2013
27
Imported loiasis in France: A retrospective analysis of 47 cases. ( 24035648 )
2013
28
Loiasis with pleural and peritoneal involvement. ( 22530827 )
2012
29
Imported Loa loa filariasis: three cases and a review of cases reported in non-endemic countries in the past 25 years. ( 22784545 )
2012
30
A Case of loiasis in a patient returning to China diagnosed by nested PCR using DNA extracted from tissue. ( 22943273 )
2012
31
Loiasis: new epidemiologic insights and proposed treatment strategy. ( 22530819 )
2012
32
Validation of the rapid assessment procedure for loiasis (RAPLOA) in the democratic republic of Congo. ( 22300872 )
2012
33
Rapid assessment procedure for loiasis and mapping lymphatic filariasis: two perfect illustrations of &amp;quot;to be in English or not to be&amp;quot;. ( 23272254 )
2012
34
Ocular loiasis in London 2008-2009: a case series. ( 21242984 )
2011
35
Subconjunctival loiasis. ( 21292882 )
2011
36
Case report: Loiasis with peripheral nerve involvement and spleen lesions. ( 21540382 )
2011
37
The geographic distribution of Loa loa in Africa: results of large-scale implementation of the Rapid Assessment Procedure for Loiasis (RAPLOA). ( 21738809 )
2011
38
A historical note on an imported case of loiasis in Rio de Janeiro, Brazil, 1964. ( 22012457 )
2011
39
Integrated rapid mapping of onchocerciasis and loiasis in the Democratic Republic of Congo: impact on control strategies. ( 20525531 )
2011
40
Assessment of loiasis and outcomes of ivermectin masstreatment in Ijebu-North, Nigeria. ( 21738271 )
2011
41
Images in clinical medicine. Ocular loiasis. ( 20848684 )
2010
42
Pulmonary loiasis and HIV coinfection in rural Cameroon. ( 20361027 )
2010
43
Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon. ( 19712455 )
2009
44
Surgical management of conjunctival loiasis. ( 18645443 )
2008
45
Market survey of loiasis: prevalence and adverse reactions to ivermectin using a rapid procedure for loiasis. ( 19565959 )
2008
46
Loiasis: African eye worm. ( 18466939 )
2008
47
Adverse reactions from community directed treatment with ivermectin (CDTI) for onchocerciasis and loiasis in Ondo State, Nigeria. ( 19419072 )
2008
48
Prevalences of loiasis in Ondo state, Nigeria, as evaluated by the rapid assessment procedure for loiasis (RAPLOA). ( 18348776 )
2008
49
Loiasis--a neglected and under-estimated affliction: endemicity, morbidity and perceptions in eastern Cameroon. ( 17316501 )
2007
50
Onchocerciasis or loiasis? ( 17258661 )
2007
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Variations for Loiasis

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Expression for Loiasis

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Search GEO for disease gene expression data for Loiasis.
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Pathways for Loiasis

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GO Terms for Loiasis

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Cellular components related to Loiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial outer membrane GO:0005741 8.62 MFF PHB2

Biological processes related to Loiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 8.62 IL10 PHB2
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Sources for Loiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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