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PASC
MCID: LNG116
MIFTS: 49

Long Covid (PASC)

Categories: Infectious diseases, Neuronal diseases, Respiratory diseases
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Aliases & Classifications for Long Covid

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MalaCards integrated aliases for Long Covid:

Name: Long Covid 11 14 75
Post-Acute Sequelae of Sars-Cov-2 Infection 11
Post-Covid Syndrome 11
Chronic Covid-19 11
Pasc 11

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Neuronal diseases Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:0080848
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Summaries for Long Covid

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Disease Ontology: 11 A Coronavirus infectious disease that is characterized by long-term persistent and fluctuating symptoms, in individuals with COVID-19, persisting beyond three to four weeks, including the loss of the ability to smell and taste, breathlessness, fatigue, difficulty in breathing, difficulty concentrating, memory loss, confusion, headache, heart palpitations, chest pain, pain with deep breaths, dizziness, and tachycardia.

MalaCards based summary: Long Covid, also known as post-acute sequelae of sars-cov-2 infection, is related to postural orthostatic tachycardia syndrome and post-traumatic stress disorder. An important gene associated with Long Covid is ACE2 (Angiotensin Converting Enzyme 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Nicotinamide and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: 75 Long COVID or long-haul COVID (also known as post-COVID-19 syndrome, post-COVID-19 condition, post-acute... more...
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Related Diseases for Long Covid

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Diseases related to Long Covid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1099)
# Related Disease Score Top Affiliating Genes
1 postural orthostatic tachycardia syndrome 30.7 REN CRP ACE2
2 post-traumatic stress disorder 30.6 IL6 IL1B CRP
3 nutritional deficiency disease 30.3 IL6 CRP CCR6
4 chronic fatigue syndrome 30.2 TNF IL6 IL1B IL10 CXCL8 CRP
5 lyme disease 30.2 TNF IL6 IL1B CRP
6 cryptogenic organizing pneumonia 30.1 CXCL8 CRP CD8A CD4
7 covid-19 30.0 TNF TMPRSS2 REN NRP1 IL6 IL1B
8 disease of mental health 30.0 TNF IL6 IL1B CRP CD4 CCR6
9 angina pectoris 30.0 TNF IL6 CRP ACE
10 toxoplasmosis 30.0 TNF IL6 IL1B IL10
11 complex regional pain syndrome 29.9 TNF IL6 IL1B IL10
12 left bundle branch hemiblock 29.9 REN CRP ACE
13 thrombocytopenic purpura, autoimmune 29.9 CD8A CD4 CCR6
14 amyloidosis 29.9 TNF IL6 IL1B FURIN CRP
15 pain agnosia 29.9 TNF IL6 IL1B IL10 CRP
16 secondary progressive multiple sclerosis 29.9 CD8A CD4 CCR6
17 adult syndrome 29.8 TNF REN IL6 CRP
18 pulmonary embolism 29.8 VWF CRP ACE2 ACE
19 cardiac tamponade 29.8 REN IL6 CRP ACE
20 sleep disorder 29.8 TNF REN IL6 IL1B IL10 CXCL8
21 pericarditis 29.8 TNF IL6 IL1B CXCL8 CRP ACE2
22 glucose intolerance 29.7 TNF IL6 CRP CCL2 ACE
23 pericardial effusion 29.7 TNF REN IL6 CRP CD4 ACE2
24 autonomic nervous system disease 29.7 TNF REN IL6 IL1B CRP ACE
25 major depressive disorder 29.7 TNF IL6 IL1B IL10 CRP
26 paine syndrome 29.7 TNF IL6 IL1B IL10 CXCL8
27 myocarditis 29.6 TNF IL6 IL1B IL10 CXCL8 CD4
28 myopathy 29.6 TNF IL6 IL1B CRP CD8A CD4
29 hypothyroidism 29.6 VWF TNF REN CRP ACE
30 fibromyalgia 29.6 TNF IL6 IL1B IL10 CXCL8 CRP
31 narcolepsy 29.6 TNF IL6 IL1B CCL2
32 anxiety 29.5 TNF IL6 IL1B IL10 CXCL8 CRP
33 lymphopenia 29.5 IL6 IL10 CCR6 BSG
34 back pain 29.5 IL6 IL1B IL10 CXCL8 CRP
35 cystitis 29.4 TNF IL6 CXCL8 CRP CCL2
36 rhinitis 29.4 TNF IL6 IL1B IL10 CXCL8
37 pfeiffer syndrome 29.4 TNF IL10 CRP CD8A CD4 CCR6
38 q fever 29.4 TNF IL6 IL1B IL10 CCL2
39 vascular disease 29.4 VWF TNF IL6 CRP CCL2 ACE
40 pheochromocytoma 29.4 TNF REN IL6 IL1B CRP ACE
41 autoimmune disease 29.4 TNF IL6 IL1B IL10 CXCL10 CRP
42 interstitial lung disease 29.4 TNF IL6 IL1B IL10 CXCL8 CRP
43 thyroiditis 29.4 TNF IL6 IL1B IL10 CXCL10 CRP
44 thrombocytopenia due to platelet alloimmunization 29.4 VWF IL10 CD8A CD4 CCR6
45 adult respiratory distress syndrome 29.4 TNF TMPRSS2 IL6 IL1B IL10 CXCL8
46 diarrhea 29.4 VWF TNF REN IL6 IL1B IL10
47 gastroesophageal reflux 29.4 TNF IL6 IL1B CXCL8 CCL2
48 lung disease 29.4 TNF IL6 IL1B IL10 CXCL8 CXCL10
49 conjunctivitis 29.4 TNF IL6 IL10 CXCL8 CCL2
50 radiculopathy 29.3 IL6 IL10 CXCL8 CRP CCL2

Graphical network of the top 20 diseases related to Long Covid:



Diseases related to Long Covid
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Symptoms & Phenotypes for Long Covid

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MGI Mouse Phenotypes related to Long Covid:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.3 BSG CCL2 CCR6 CD4 CD8A CXCL10
2 homeostasis/metabolism MP:0005376 10.28 ACE ACE2 BSG CCL2 CCR6 CD4
3 cellular MP:0005384 10.13 ACE ACE2 BSG CCL2 CD4 CD8A
4 cardiovascular system MP:0005385 10.13 ACE ACE2 CCL2 CCR6 CRP CXCL10
5 immune system MP:0005387 10.11 ACE ACE2 BSG CCL2 CCR6 CD4
6 muscle MP:0005369 10.09 ACE2 BSG CCL2 IL10 IL6 NRP1
7 neoplasm MP:0002006 10.08 ACE CCL2 IL10 IL1B IL6 NRP1
8 digestive/alimentary MP:0005381 9.97 ACE2 CCL2 CD4 FURIN IL10 IL6
9 hematopoietic system MP:0005397 9.86 ACE ACE2 BSG CCL2 CCR6 CD4
10 mortality/aging MP:0010768 9.53 ACE ACE2 BSG CCL2 CD4 CD8A
Sources

Drugs & Therapeutics for Long Covid

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Drugs for Long Covid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 200)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
2
Infliximab Approved Phase 4 170277-31-3
3
Remdesivir Approved, Investigational Phase 4 1809249-37-3 121304016
4
Dextroamphetamine Approved, Illicit, Investigational Phase 4 51-64-9, 300-62-9 5826 3007
5
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
6
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
8
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 70-16-6 1130
9 Vitamin B3 Phase 4
10 Nicotinic Acids Phase 4
11 Dermatologic Agents Phase 4
12 Antirheumatic Agents Phase 4
13 Antimetabolites Phase 4
14
Imatinib Mesylate Phase 4 220127-57-1
15 Protein Kinase Inhibitors Phase 4
16 Central Nervous System Stimulants Phase 4
17 Adrenergic Agents Phase 4
18 Dopamine Uptake Inhibitors Phase 4
19 Adderall Phase 4
20 Dopamine Agents Phase 4
21 Sympathomimetics Phase 4
22 Vitamins Phase 4
23 Folate Phase 4
24 Vitamin B9 Phase 4
25 Trace Elements Phase 4
26 Vitamin B Complex Phase 4
27 Micronutrients Phase 4
28 Vitamin B1 Phase 4
29 Thiamin Phase 4
30
Ethanol Approved Phase 2, Phase 3 64-17-5 702
31
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 5284616 6436030
32
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
33
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
34
Montelukast Approved Phase 3 158966-92-8 5281040
35
Atorvastatin Approved Phase 3 134523-00-5 60823
36
Pentoxifylline Approved, Investigational Phase 2, Phase 3 6493-05-6 4740
37
Ritonavir Approved, Investigational Phase 3 155213-67-5 392622
38
Coal tar Approved Phase 3 8007-45-2
39
Metronidazole Approved Phase 3 443-48-1, 69198-10-3 4173
40
Ibudilast Investigational Phase 2, Phase 3 50847-11-5 3671
41 Pharmaceutical Solutions Phase 2, Phase 3
42 Pyruvate Phase 2, Phase 3
43 Schisandra Phase 2, Phase 3
44 Anti-Bacterial Agents Phase 2, Phase 3
45 Antifungal Agents Phase 2, Phase 3
46 Antibiotics, Antitubercular Phase 2, Phase 3
47 Immunosuppressive Agents Phase 2, Phase 3
48 Leukotriene Antagonists Phase 3
49 Hypolipidemic Agents Phase 3
50 Anticholesteremic Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 159)
# Name Status NCT ID Phase Drugs
1 Long-term Follow-up of a Randomized Multicenter Trial on Impact of Imatinib and Infliximab on Long-COVID in Hospitalized COVID-19 Patients Recruiting NCT05220280 Phase 4 Imatinib;Infliximab
2 Randomized, Placebo-controlled Parallel Group Clinical Trial of Nicotinamide Riboside to Evaluate NAD+ Levels in Individuals With Persistent Cognitive and Physical Symptoms After COVID-19 Illness ("Long-COVID") Recruiting NCT04809974 Phase 4 Niagen
3 Long-term Follow-up of a Randomized Multicenter Trial on Impact of Long-COVID in Hospitalized COVID-19 Patients Recruiting NCT04978259 Phase 4 Remdesivir
4 Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients Not yet recruiting NCT05597722 Phase 4 Amphetamine-Dextroamphetamine
5 Post-COVID-19 Chronic Fatigue Syndrome Not yet recruiting NCT05642923 Phase 4 Synthetic Vitamin B1
6 Preliminary Examination of the Effects of Sodium Pyruvate Nasal Spray (N115) on Symptoms Associated With COVID19 Long Haulers. Completed NCT04871815 Phase 2, Phase 3 sodium pyruvate nasal spray
7 Effect of ADAPT232 Supplementation on Recovery of Patients in Rehabilitation Period in Long COVID-19: a Randomized, Double-blind, Placebo-controlled Trial Completed NCT04795557 Phase 2, Phase 3
8 SECOVID: A Multi-center, Randomized, Dose-ranging Parallel-group Trial Assessing the Efficacy of Sirolimus in Hospitalized Patients With COVID-19 Pneumonia for the Prevention of Post-COVID Fibrosis Recruiting NCT04948203 Phase 2, Phase 3 Sirolimus
9 Double-blind Randomized Clinical Trial, Placebo-controlled to Assess the Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19: E-SPERANZA COVID-19 PROJECT Recruiting NCT04695704 Phase 3 Montelukast
10 An International, Investigator Initiated and Conducted, Pragmatic Clinical Trial to Determine Whether 40mg Atorvastatin Daily Can Improve Neurocognitive Function in Adults With Long COVID Neurological Symptoms Recruiting NCT04904536 Phase 3 Atorvastatin
11 REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) Trial Not yet recruiting NCT05513560 Phase 2, Phase 3 Ibudilast;Pentoxifylline
12 Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients Not yet recruiting NCT05618574 Phase 3
13 Efficacy of Antivirals and Other Therapeutics for Treatment of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Not yet recruiting NCT05595369 Phase 3 Paxlovid;Placebo
14 A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of AXA1125 in Subjects With Fatigue-Predominant Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection Completed NCT05152849 Phase 2 AXA1125;Placebo
15 A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients Recruiting NCT04482595 Phase 2 BIO 300 Oral Suspension;Placebo
16 Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC Recruiting NCT05576662 Phase 2 Nirmatrelvir;Placebo;Ritonavir
17 Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. Recruiting NCT05618587 Phase 2 Lithium;Placebo
18 A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisite Pain Associated With Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Recruiting NCT05472090 Phase 2 TNX-102 SL;Placebo SL Tablet
19 Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study Recruiting NCT04997395 Phase 2 MediCabilis Cannabis sativa 50
20 A Randomised Phase II Study to Investigate the Effectiveness of ACUpuncture for the Relief of Long COVID Related Fatigue. Recruiting NCT05212688 Phase 2
21 Hyperbaric Oxygen for Treatment of Long COVID Syndrome; A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial Recruiting NCT04842448 Phase 2 Hyperbaric oxygen
22 Temelimab as a Disease Modifying Therapy in Patients With Neurological, Neuropsychological, and Psychiatric (=Neuropsychiatric) Symptoms in Post-COVID 19 or Postacute Sequelae of COVID-19 (PASC) Syndrome Recruiting NCT05497089 Phase 2 Temelimab 54mg/kg;Placebo
23 Pilot Study Into Low Dose Naltrexone (LDN) and Nicotinamide Adenine Dinucleotide (NAD+) for Treatment of Patients With Post-COVID-19 Syndrome (Long-COVID19) Active, not recruiting NCT04604704 Phase 2 Naltrexone
24 A Phase 2, Double-blind, Placebo-controlled Study of RSLV-132 in Subjects With Post-acute COVID-19 (Long COVID) Active, not recruiting NCT04944121 Phase 2 RSLV-132;Sodium Chloride 0.9%
25 Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (IN-PASC) Enrolling by invitation NCT05350774 Phase 2 IV immunoglobulin;IV normal saline;IV methylprednisolone
26 A Phase 2, Multicenter, Open Label, Clinical Trial Evaluating Safety and Activity of Nivolumab/Ipilimumab and Chemotherapy Combination in Advanced NSCLC Patients With HIV, HBV, HCV and Post-acute Sequelae of SARS-CoV2 Infection (PASC). Not yet recruiting NCT05597800 Phase 2 Nivolumab and Ipilimumab
27 A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions Not yet recruiting NCT05592418 Phase 2 Rintatolimod
28 A Randomized, Placebo-Controlled Phase II Study To Evaluate The Safety, Tolerability And Efficacy Of S-1226 In Post-Covid-19 Subjects With Persistent Respiratory Symptoms. Not yet recruiting NCT04949386 Phase 2 S-1226 (8%)
29 Detailed Study on the Safety, Dosage and Feasibility of an Intervention Based on a Computerized Cognitive Training (CCT) for Individuals With Post-acute Sequelae of COVID-19 (PASC): A Phase I/II Trial Not yet recruiting NCT05582603 Phase 1, Phase 2
30 Hyperbaric Oxygen Therapy for Long COVID Patients With Pulmonary Sequela - Pilot Study Suspended NCT04905888 Phase 2
31 Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia (FluCOP Trial) Withdrawn NCT05216614 Phase 2 Fluvoxamine;Placebo
32 A Randomized, Double-Blinded, Placebo-Controlled Phase I Study to Evaluate the Safety and Efficacy of Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long COVID) Completed NCT04880161 Phase 1
33 Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) Recruiting NCT05638620 Phase 1 stellate ganglion block with 0.5% bupivacaine
34 Post Covid Syndrome: Clinical Pattern and Functional Assessment Unknown status NCT04561141
35 Sociodemographic,Clinical,Quality of Life, and Health Care Conditions After Hospital Discharge in Patients Who Required Admission to ICU for COVID-19 at Hospital Universitario Nacional Between April 2020 and March 2021. Bogotá, Colombia Completed NCT05185674
36 Before-and-after Study on the Impact of a Home-based Personalized Computerized Training Program on Cognitive Dysfunction Associated With Long COVID Completed NCT05571852
37 A Multicenter, Observational, 6-Month Follow-up Study of Patients With COVID-19 Previously Enrolled in a RO7496998 (AT-527) Study Completed NCT05059080
38 Analysis of the Relationship Between Clinical and Haematological Phenotypes in Long COVID Completed NCT04659889
39 Risk Factors for Post-coronavirus Disease-2019 Fatigue: a Prospective Case-control Study Completed NCT04851561
40 A Longitudinal Observational Study to Investigate the Patterns of Change in the Tidal Breathing CO2 Waveform, Measured Using the N-Tidal C Handset, in Patients With COPD Compared to Patients With Other Common Cardiorespiratory Conditions Completed NCT04939558
41 Study of Vascular Endothelial Glycocalyx and Ophthalmic Injury in a Single-center, Cross-sectional, Prospective Cohort of Patients With Prolonged Post-COVID-19 Symptoms Completed NCT05235698
42 SingStrong: Strong Lungs Through Song Completed NCT04810065
43 Lung Diffusing Capacities for Nitric Oxide and Carbon Monoxide in Long COVID With Dyspnea at Rest and After Mild Exercise Completed NCT05430503
44 Effects of Palmitoylethanolamide Co-ultramicronized With Luteoline (Pea-lut) on Frontal Lobe Functions and GABAergic Transmission in Long Covid Patients. An 8-week Randomized Controlled Trial. Completed NCT05311852
45 AIDA - A Digital Health Intervention Based on Artificial Intelligence to Support the Personalized Recovery of Long COVID Patients: Feasibility Study. Completed NCT05483829
46 Endocrine, Metabolic and Microbiome Influence on the Post-COVID Syndrome Completed NCT04860869
47 The UK Interstitial Lung Disease Long-COVID19 Study (UKILD-Long COVID): Understanding the Burden of Interstitial Lung Disease in Long COVID. Recruiting NCT05514522
48 Munich Long COVID Registry Study for Children, Adolescents and Adults (MLC-R) Recruiting NCT05638724
49 Post-Covid Condition Monitoring Cohort: Evaluation of the Evolution of Symptomatology, Patient Profile and Associated Prognostic Factors Recruiting NCT05610436
50 Interventional, Prospective, National, Multicentre, Randomised, Open-label, Controlled Clinical Study Comparing Two Parallel Groups, One Control Arm (Standard Treatment) Versus Intervention Arm (Standard Treatment + Study Product) Evaluating the Efficacy of Respicure® 0.38% /0.38% (Resveratrol / Quercetin) Phytotherapy Product From BEKER® Laboratories as an add-on Treatment in the Management of Respiratory Conditions Including Asthma (Partially Controlled),Chronic Obstructive Pulmonary Disease "COPD" (Stage A, B, C and D) and Long Coronavirus Disease "COVID" in Algerian Adult Patients . Recruiting NCT05601180

Search NIH Clinical Center for Long Covid

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Genetic Tests for Long Covid

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Anatomical Context for Long Covid

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Organs/tissues related to Long Covid:

MalaCards : Heart, Brain, Lung, Skeletal Muscle, Liver, Endothelial, Kidney
Sources

Publications for Long Covid

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Articles related to Long Covid:

(show top 50) (show all 2381)
# Title Authors PMID Year
1
Sex-Related Differences in Acuity and Postoperative Complications, Mortality and Failure to Rescue. 62
36244225 2023
2
Dysautonomia: Diagnosis and Management. 62
36400555 2023
3
Association of Insurance Type With Inpatient Surgery 30-Day Complications and Costs. 62
36244224 2023
4
Reliability and validity of the post COVID-19 condition stigma questionnaire: A prospective cohort study. 62
36447641 2023
5
The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: A systematic review and meta-analysis. 62
36474804 2023
6
Long COVID and Mitochondrial Dysfunction. 62
36378091 2023
7
National long COVID impact and risk factors. 62
36434908 2022
8
Undiagnosed Long COVID-19 in China Among Non-vaccinated Individuals: Identifying Persistent Symptoms and Impacts on Patients' Health-Related Quality of Life. 62
36434150 2022
9
Long COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: Similarities and differences of two peas in a pod. 62
35693424 2022
10
Viral Infection, Pulmonary Fibrosis, and Long Covid. 62
36470237 2022
11
"I feel like my body is broken": exploring the experiences of people living with long COVID. 62
35816258 2022
12
Rapid improvement in severe long COVID following perispinal etanercept. 62
35791687 2022
13
The long-COVID-19 in older adults: facts and conjectures. 62
35662207 2022
14
Healthy outcomes of patients with COVID-19 two years after the infection: a prospective cohort study. 62
36215047 2022
15
High Prevalence of Long-COVID Among Kidney Transplant Recipients: A Longitudinal Cohort Study. 62
36228200 2022
16
Mental and physical health should be evaluated in children and adolescents with long COVID. 62
36457246 2022
17
Chronic fatigue and affective symptoms in Acute and Long COVID are attributable to immune-inflammatory pathways. 62
36454120 2022
18
Psychological consequences of long COVID: comparing trajectories of depressive and anxiety symptoms before and after contracting SARS-CoV-2 between matched long- and short-COVID groups. 62
36458509 2022
19
Long COVID: defining the role of rheumatology in care and research. 62
36211989 2022
20
Long COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: Similarities and differences of two peas in a pod. 62
36435560 2022
21
Post-Covid-19 Gastro-Intestinal Disturbances. 62
36464877 2022
22
How long is long COVID. 62
36468196 2022
23
[How frequent is long COVID really?] 62
36475055 2022
24
General practitioners should provide the cardiorespiratory rehabilitation' 'minimum advice' for long COVID-19 patients. 62
34839808 2022
25
Protracted stress-induced hypocortisolemia may account for the clinical and immune manifestations of Long COVID. 62
36182048 2022
26
Long Covid at the crossroads: Comparisons and lessons from the treatment of patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). 62
35341334 2022
27
Long covid and medical gaslighting: Dismissal, delayed diagnosis, and deferred treatment. 62
36092770 2022
28
Long COVID symptoms in a population-based sample of persons discharged home from hospital. 62
36131218 2022
29
Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome. 62
36461167 2022
30
Post COVID-19 neuropsychiatric complications and therapeutic role for TNF-α inhibitors: a case series study. 62
36267491 2022
31
Post-COVID-19 respiratory problems: burden and management. 62
36326730 2022
32
Health-related quality of life in survivors of severe COVID-19 infection. 62
36376776 2022
33
Excess of Post-Acute Sequelae of COVID-19 After the First Wave of the Pandemic. 62
36156194 2022
34
Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomics. 62
36152884 2022
35
Post COVID-19 syndrome with impairment of flow-mediated epicardial vasodilation and flow reserve. 62
36083297 2022
36
COVID-19: Lessons on malnutrition, nutritional care and public health from the ESPEN-WHO Europe call for papers. 62
36075815 2022
37
Evaluation of post-COVID health status using the EuroQol-5D-5L scale. 62
35129097 2022
38
Critical role of diagnostic SARS-CoV-2 T cell assays for immunodeficient patients. 62
36216482 2022
39
Cochrane "evidence relevant to" rehabilitation of people with post COVID-19 condition. What it is and how it has been mapped to inform the development of the World Health Organization recommendations. 62
36468825 2022
40
Spotlights on the latest opinions on identification, prevention, and management of newer CoV-2 variants: A roundup appraisal on innovative ideas and designer vaccines for Omicron. 62
35811273 2022
41
Time-dependent recovery of brain hypometabolism in neuro-COVID-19 patients. 62
35984451 2022
42
Covid-19 infection in children and adolescents and its association with type 1 diabetes mellitus (T1d) presentation and management. 62
36462147 2022
43
Network autonomic analysis of post-acute sequelae of COVID-19 and postural tachycardia syndrome. 62
36169757 2022
44
Clinical assessment of children with long COVID syndrome. 62
36474113 2022
45
Creative Long Covid: A qualitative exploration of the experience of Long Covid through the medium of creative narratives. 62
36148648 2022
46
Efficacy of chemotherapy for patients with metastatic or recurrent pancreatic adenosquamous carcinoma: A multicenter retrospective analysis. 62
36150984 2022
47
SARS-CoV-2 infection increases the gene expression profile for Alzheimer's disease risk. 62
36187720 2022
48
Post-COVID-19 syndrome/condition or long COVID: Persistent illness after acute SARS CoV-2 infection. 62
36451331 2022
49
Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes. 62
36456834 2022
50
Inhibition of MEK signaling prevents SARS-CoV2-induced lung damage and improves the survival of infected mice. 62
36030555 2022
Sources

Variations for Long Covid

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Expression for Long Covid

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Search GEO for disease gene expression data for Long Covid.
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Pathways for Long Covid

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Pathways related to Long Covid according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.02 TNF IL6 IL1B IL10 CXCL8 CXCL10
2
ERK Signaling 64
Show member pathways
 13.86 TNF NRP1 IL6 IL1B IL10 CXCL8
3
Disease 66
Show member pathways
 13.85 VWF TMPRSS2 NRP1 IL6 IL1B IL10
4
Signal Transduction 66
13.8 CCL2 CCR6 CXCL10 CXCL8 FURIN IL6
5
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.67 CCL2 CCR6 CD4 CXCL10 CXCL8 IL10
6
Akt Signaling 64
Show member pathways
 13.46 CCL2 CCR6 CD4 CXCL10 CXCL8 IL10
7
Cytokine Signaling in Immune system 66
Show member pathways
 13.37 CCL2 CD4 CXCL10 CXCL8 IL10 IL1B
8
PAK Pathway 64
Show member pathways
 13.31 CCL2 CCR6 CD4 CXCL10 CXCL8 IL10
9
CCR5 Pathway in Macrophages 64
Show member pathways
 12.88 CXCL8 CXCL10 CD4 CCR6 CCL2
10
Toll-like receptor signaling pathway 74
Show member pathways
 12.86 TNF IL6 IL1B CXCL8 CXCL10
11
Malignant pleural mesothelioma 74
12.73 CCL2 CXCL10 IL10 IL1B IL6
12
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.69 TNF NRP1 IL6 IL1B IL10 CXCL8
13
Immune response IL-23 signaling pathway 22
Show member pathways
 12.65 CCL2 CD4 IL10 IL1B IL6 TNF
14
NF-kappaB Signaling 3
12.62 TNF IL1B IL10 CXCL10 CD8A CCL2
15
Toll-Like receptor Signaling Pathways 65
Show member pathways
 12.53 TNF IL6 IL1B CXCL8
16
Bacterial infections in CF airways 22
Show member pathways
 12.48 TNF IL6 IL1B CXCL8 CXCL10
17
Early SARS-CoV-2 Infection Events 66
Show member pathways
 12.42 TMPRSS2 NRP1 FURIN ACE2
18
IL-17 Family Signaling Pathways 65
Show member pathways
 12.35 TNF IL6 CXCL8 CXCL10 CCL2
19
Toll Comparative Pathway 64
Show member pathways
 12.34 TNF IL6 IL1B CXCL8
20
Sudden infant death syndrome (SIDS) susceptibility pathways 74
12.24 TNF IL6 IL1B IL10 CXCL8
21
T-cell activation SARS-CoV-2 74
Show member pathways
 12.19 TNF IL10 CD8A CD4
22
Neuroinflammation and glutamatergic signaling 74
12.15 TNF IL6 IL1B IL10
23
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 12.11 CXCL8 CXCL10 CCR6 CCL2
24
Hematopoietic Stem Cells and Lineage-specific Markers 65
12.07 TNF IL6 IL10 CD8A CD4
25
ACE Inhibitor Pathway, Pharmacodynamics 60
Show member pathways
 12.05 TNF REN ACE2 ACE
26
Spinal cord injury 74
12.05 TNF IL6 IL1B CXCL8 CXCL10 CCL2
27
Interleukin-4 and Interleukin-13 signaling 66
12.01 CCL2 CXCL8 IL10 IL1B IL6 TNF
28
IL27-mediated signaling events 61
Show member pathways
 12 TNF IL6 IL1B IL10 CD4
29
CCL18 signaling pathway 74
11.96 IL6 IL10 CXCL8 CCR6 CCL2
30
Allograft rejection 74
11.95 TNF IL1B IL10 CXCL8
31
Innate Lymphoid Cells Differentiation 65
11.84 TNF IL1B IL10 CD8A CD4 CCR6
32
Burn wound healing 74
11.83 TNF IL6 IL1B CXCL8 CCL2
33
Extrafollicular B cell activation by SARS-CoV-2 74
11.82 TNF IL6 IL10 CRP
34
AP-1 transcription factor network 61
11.8 IL6 IL10 CXCL8 CCL2
35
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.8 IL6 CXCL8 CRP CD8A CD4 CCL2
36
Acute viral myocarditis 74
11.78 IL6 IL10 CD4
37
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.76 TNF IL6 IL1B CXCL8
38
Th17 cell differentiation pathway 74
11.74 IL6 IL1B CD4
39
miRNAs involvement in the immune response in sepsis 74
11.74 TNF IL6 IL10 CXCL8
40
IL 10 signaling pathway 67
11.74 TNF IL6 IL1B IL10
41
Dendritic Cells Developmental Lineage Pathway 65
11.73 TNF NRP1 IL6 IL1B IL10 CD8A
42
Lung fibrosis 74
11.72 TNF IL6 IL1B CXCL8 CCL2
43
Inflammatory bowel disease signaling 74
Show member pathways
 11.67 TNF IL6 IL10
44
Non-genomic actions of 1,25 dihydroxyvitamin D3 74
11.63 CCL2 CXCL8 IL6 TNF
45
Netrin-UNC5B signaling pathway 74
11.62 TNF IL10 CCL2
46
SARS-CoV-2 innate immunity evasion and cell-specific immune response 74
11.59 ACE2 BSG CCL2 CXCL8 IL10 TNF
47
MSP-RON Signaling 64
11.58 TNF IL1B CCL2
48
Nonalcoholic fatty liver disease 74
11.56 CCL2 IL6 TNF
49
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.55 TNF IL6 IL1B
50
Fibrin complement receptor 3 signaling pathway 74
11.55 TNF IL6 CXCL10 CCL2
Sources

GO Terms for Long Covid

About this section

Cellular components related to Long Covid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005887 10.23 ACE BSG CCR6 CD4 CD8A NRP1
2 plasma membrane GO:0005886 10.23 ACE BSG CCR6 CD4 CD8A NRP1
3 external side of plasma membrane GO:0009897 10.1 TNF CXCL10 CD8A CD4 CCR6 ACE
4 extracellular space GO:0005615 10.09 ACE ACE2 CCL2 CRP CXCL10 CXCL8
5 membrane raft GO:0045121 9.96 TNF FURIN CD4 BSG ACE2
6 extracellular region GO:0005576 9.84 ACE ACE2 CCL2 CD8A CRP CXCL10

Biological processes related to Long Covid according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.61 TNF NRP1 IL6 IL1B IL10 CXCL8
2 inflammatory response GO:0006954 10.32 TNF IL6 IL1B CXCL8 CXCL10 CRP
3 defense response to Gram-positive bacterium GO:0050830 10.25 TNF IL6 IL1B CRP
4 positive regulation of DNA-binding transcription factor activity GO:0051091 10.24 TNF IL6 IL1B IL10
5 viral entry into host cell GO:0046718 10.21 NRP1 CD4 BSG ACE2
6 calcium-mediated signaling GO:0019722 10.19 TNF CXCL8 CD4 CCR6
7 chemokine-mediated signaling pathway GO:0070098 10.15 CCL2 CCR6 CXCL10 CXCL8
8 lipopolysaccharide-mediated signaling pathway GO:0031663 10.13 TNF IL1B CCL2
9 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.11 IL10 IL6 TNF
10 humoral immune response GO:0006959 10.11 TNF IL6 CCR6 CCL2
11 liver regeneration GO:0097421 10.08 TNF IL6 IL10
12 negative regulation of neurogenesis GO:0050768 10.05 TNF IL6 IL1B
13 neutrophil chemotaxis GO:0030593 10.02 IL1B CXCL8 CXCL10 CCL2 BSG
14 positive regulation of glial cell proliferation GO:0060252 10.01 TNF IL6 IL1B
15 positive regulation of vascular endothelial growth factor production GO:0010575 10 BSG IL1B IL6
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10 TNF IL1B FURIN
17 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.97 ACE2 ACE
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.97 IL10 IL1B TNF
19 negative regulation of cytokine production involved in immune response GO:0002719 9.96 TNF IL10
20 positive regulation of fever generation GO:0031622 9.96 IL1B TNF
21 cellular response to interleukin-17 GO:0097398 9.94 IL1B CXCL10
22 angiogenesis involved in coronary vascular morphogenesis GO:0060978 9.93 NRP1 ACE
23 positive regulation of neuroinflammatory response GO:0150078 9.93 TNF IL6 IL1B
24 sequestering of triglyceride GO:0030730 9.92 TNF IL1B
25 viral life cycle GO:0019058 9.92 FURIN ACE2
26 negative regulation of lipid storage GO:0010888 9.91 TNF IL6 CRP
27 response to lipopolysaccharide GO:0032496 9.91 TNF REN IL1B IL10 CXCL10 ACE
28 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.89 TNF IL1B
29 angiotensin maturation GO:0002003 9.88 ACE ACE2 REN
30 negative regulation of gap junction assembly GO:1903597 9.87 IL1B ACE
31 chronic inflammatory response to antigenic stimulus GO:0002439 9.86 TNF IL10
32 vascular endothelial growth factor production GO:0010573 9.85 TNF IL6 IL1B
33 cellular response to lipopolysaccharide GO:0071222 9.77 TNF IL6 IL1B IL10 CXCL8 CXCL10
34 positive regulation of viral entry into host cell GO:0046598 9.7 BSG CD4 FURIN TMPRSS2
35 immune response GO:0006955 9.47 TNF IL6 IL1B IL10 CXCL8 CXCL10

Molecular functions related to Long Covid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.73 NRP1 CD8A CD4
2 endopeptidase activity GO:0004175 9.5 REN FURIN ACE2 ACE
3 peptidyl-dipeptidase activity GO:0008241 9.46 ACE2 ACE
4 cytokine activity GO:0005125 9.36 TNF IL6 IL1B IL10 CXCL8 CXCL10
Sources

Sources for Long Covid

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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