Long Qt Syndrome 15 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

LQT15 MCID: LNG096 MIFTS: 38	Long Qt Syndrome 15 (LQT15) Categories: Blood diseases, Cardiovascular diseases, Genetic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Long Qt Syndrome 15

MalaCards integrated aliases for Long Qt Syndrome 15:

Name: Long Qt Syndrome 15 ⁵⁷ ¹² ⁷⁴ ²⁹ ⁶ ¹⁵ ⁷²

Lqt15 ⁵⁷ ¹² ⁷⁴

Long Qt Syndrome, Type 15 ⁴⁰

Characteristics:

OMIM:

⁵⁷

Inheritance:
autosomal dominant

Miscellaneous:
onset at birth or in early childhood

HPO:

³²

long qt syndrome 15:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the circulatory system

Other forms of heart disease

Other conduction disorders

Other specified conduction disorders

External Ids:

Disease Ontology ¹² DOID:0110656

OMIM ⁵⁷ 616249 PS192500

MeSH ⁴⁴ D008133

ICD10 ³³ I45.8

MedGen ⁴² C4015695 CN228134

UMLS ⁷² C4015695

Sources

Summaries for Long Qt Syndrome 15

UniProtKB/Swiss-Prot : ⁷⁴ Long QT syndrome 15: A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

MalaCards based summary : Long Qt Syndrome 15, also known as lqt15, is related to long qt syndrome 1 and long qt syndrome. An important gene associated with Long Qt Syndrome 15 is CALM2 (Calmodulin 2), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and B Cell Receptor Signaling Pathway (sino). Affiliated tissues include heart, and related phenotypes are cardiac arrest and bradycardia

Disease Ontology : ¹² A long QT syndrome that has material basis in dominant inheritance of mutation in the CALM2 gene on chromosome 2p21.

More information from OMIM: 616249 PS192500

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Related Diseases for Long Qt Syndrome 15

Diseases in the Long Qt Syndrome family:

Long Qt Syndrome 1	Long Qt Syndrome 3
Long Qt Syndrome 9	Long Qt Syndrome 10
Long Qt Syndrome 11	Long Qt Syndrome 12
Long Qt Syndrome 13	Long Qt Syndrome 2
Long Qt Syndrome 6	Long Qt Syndrome 5
Long Qt Syndrome 14	Long Qt Syndrome 15
Long Qt Syndrome 8	Familial Long Qt Syndrome

Diseases related to Long Qt Syndrome 15 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)

#	Related Disease	Score	Top Affiliating Genes
1	long qt syndrome 1	9.7	CALM2 CALM1
2	long qt syndrome	9.7	CALM2 CALM1
3	external ear disease	9.7	CALM2 CALM1
4	otomycosis	9.7	CALM2 CALM1
5	otitis externa	9.7	CALM2 CALM1
6	sporotrichosis	9.7	CALM2 CALM1
7	emery-dreifuss muscular dystrophy 5, autosomal dominant	9.7	CALM2 CALM1
8	spontaneous ocular nystagmus	9.7	CALM2 CALM1
9	deafness, autosomal recessive 44	9.7	CALM2 CALM1
10	acute dacryocystitis	9.7	CALM2 CALM1
11	dystonia 24	9.7	CALM2 CALM1
12	gestational choriocarcinoma	9.7	CALM2 CALM1
13	triosephosphate isomerase deficiency	9.7	CALM2 CALM1
14	tinea unguium	9.6	CALM2 CALM1
15	leber congenital amaurosis 2	9.6	CALM2 CALM1
16	clear cell acanthoma	9.6	CALM2 CALM1
17	primary systemic mycosis	9.6	CALM2 CALM1
18	cardiomyopathy, dilated, 1p	9.6	CALM2 CALM1
19	cardiomyopathy, dilated, 1a	9.6	CALM2 CALM1
20	phaeohyphomycosis	9.5	CALM2 CALM1
21	microcephaly 2, primary, autosomal recessive, with or without cortical malformations	9.5	CALM2 CALM1
22	deafness, autosomal dominant 2a	9.5	CALM2 CALM1
23	ceroid lipofuscinosis, neuronal, 11	9.4	CALM2 CALM1
24	primary cutaneous amyloidosis	9.4	CALM2 CALM1
25	catecholaminergic polymorphic ventricular tachycardia	9.3	CALM2 CALM1
26	cardiac arrest	9.1	CALM2 CALM1

Graphical network of the top 20 diseases related to Long Qt Syndrome 15:

Sources

Symptoms & Phenotypes for Long Qt Syndrome 15

Human phenotypes related to Long Qt Syndrome 15:

³²

#	Description	HPO Frequency	HPO Source Accession
1	cardiac arrest ³²	occasional (7.5%)	HP:0001695
2	bradycardia ³²	occasional (7.5%)	HP:0001662
3	prolonged qtc interval ³²		HP:0005184
4	ventricular fibrillation ³²		HP:0001663

Symptoms via clinical synopsis from OMIM:

⁵⁷

Cardiovascular Heart:
cardiac arrest (in some patients)
bradycardia (in some patients)
recurrent episodes of ventricular fibrillation
sudden death (in some patients) prolonged qtc interval on electrocardiogram (ecg)
notched t waves on ecg (in some patients)
more

Prenatal Manifestations:
fetal bradycardia (in some patients)

Clinical features from OMIM:

616249

GenomeRNAi Phenotypes related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00173-A	9.36	CALM2
2	Decreased viability	GR00221-A-1	9.36	CALM2
3	Decreased viability	GR00221-A-2	9.36	CALM1 CALM2
4	Decreased viability	GR00221-A-3	9.36	CALM1
5	Decreased viability	GR00221-A-4	9.36	CALM1 CALM2
6	Decreased viability	GR00301-A	9.36	CALM1 CALM2
7	Decreased viability	GR00402-S-2	9.36	CALM1 CALM2

Sources

Drugs & Therapeutics for Long Qt Syndrome 15

Search Clinical Trials , NIH Clinical Center for Long Qt Syndrome 15

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Genetic Tests for Long Qt Syndrome 15

Genetic tests related to Long Qt Syndrome 15:

#	Genetic test	Affiliating Genes
1	Long Qt Syndrome 15 ²⁹	CALM2

Sources

Anatomical Context for Long Qt Syndrome 15

MalaCards organs/tissues related to Long Qt Syndrome 15:

⁴¹

Heart

Sources

Publications for Long Qt Syndrome 15

Articles related to Long Qt Syndrome 15:

#	Title	Authors	PMID	Year
1	Novel calmodulin mutations associated with congenital arrhythmia susceptibility. ⁸ ⁷¹	Makita N...George AL	24917665	2014
2	Calmodulin mutations associated with recurrent cardiac arrest in infants. ⁸ ⁷¹	Crotti L...George AL	23388215	2013
3	Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. ⁷¹	Priori SG...Asia Pacific Heart Rhythm Society	23994779	2013
4	Long QT Syndrome ⁷¹	Alders M...Christiaans I	20301308	2003
5	Long QT syndrome with a de novo CALM2 mutation in a 4-year-old boy. ³⁸	Fujita S...Hatasaki K	31283864	2019
6	Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation. ³⁸	Yamamoto Y...Kimura T	28335032	2017

Sources

Genes for Long Qt Syndrome 15

Genes related to Long Qt Syndrome 15 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CALM2	Calmodulin 2	Protein Coding	1336.39	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative variation ⁷⁴ Genetic Tests ²⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)	23388215 24917665 20301308
2	CALM1	Calmodulin 1	Protein Coding	16.87	DISEASES inferred ¹⁵
3	CD2AP	CD2 Associated Protein	Protein Coding	14.95	DISEASES inferred ¹⁵

Sources

Variations for Long Qt Syndrome 15

ClinVar genetic disease variations for Long Qt Syndrome 15:

⁶

#	Gene	Variation	Type	Significance	SNP ID	GRCh37 Pos	GRCh38 Pos
1	CALM2	NM_001305625.1(CALM2): c.306C> G (p.Asn102Lys)	single nucleotide variant	Pathogenic	rs1553431702	2:47388869-47388869	2:47161730-47161730
2	CALM2	NM_001305625.1(CALM2): c.179A> T (p.Asp60Val)	single nucleotide variant	Pathogenic	rs730882254	2:47388996-47388996	2:47161857-47161857
3	CALM2	NM_001305625.1(CALM2): c.185A> G (p.Asn62Ser)	single nucleotide variant	Pathogenic/Likely pathogenic	rs398124647	2:47388990-47388990	2:47161851-47161851
4	CALM2	NM_001305625.1(CALM2): c.185A> T (p.Asn62Ile)	single nucleotide variant	Pathogenic/Likely pathogenic	rs398124647	2:47388990-47388990	2:47161851-47161851
5	CALM2	NM_001305625.1(CALM2): c.288T> G (p.Asp96Glu)	single nucleotide variant	Pathogenic/Likely pathogenic	rs398124648	2:47388887-47388887	2:47161748-47161748
6	CALM2	NM_001305625.1(CALM2): c.292G> C (p.Asp98His)	single nucleotide variant	Pathogenic/Likely pathogenic	rs398124650	2:47388883-47388883	2:47161744-47161744
7	CALM2	NM_001305625.1(CALM2): c.299A> C (p.Gln100Pro)	single nucleotide variant	Pathogenic/Likely pathogenic	rs398124649	2:47388876-47388876	2:47161737-47161737
8	CALM2	NM_001305625.1(CALM2): c.292G> A (p.Asp98Asn)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs398124650	2:47388883-47388883	2:47161744-47161744

UniProtKB/Swiss-Prot genetic disease variations for Long Qt Syndrome 15:

⁷⁴

#	Symbol	AA change	Variation ID	SNP ID
1	CALM2	p.Asp96Val	VAR_073276	rs730882254
2	CALM2	p.Asn98Ile	VAR_073277	rs398124647
3	CALM2	p.Asp132Glu	VAR_073279	rs398124648
4	CALM2	p.Asp134His	VAR_073280	rs398124650
5	CALM2	p.Gln136Pro	VAR_073281	rs398124649
6	CALM2	p.Asp130Val	VAR_078262
7	CALM2	p.Asn98Ser	VAR_078543	rs398124647
8	CALM2	p.Asp130Gly	VAR_078544	rs730882252

Sources

Expression for Long Qt Syndrome 15

Search GEO for disease gene expression data for Long Qt Syndrome 15.

Sources

Pathways for Long Qt Syndrome 15

Pathways related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

(show top 50) (show all 62)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of fat-soluble vitamins ⁶⁶ Show member pathways Metabolism of vitamin K ⁶⁶ Retinoid metabolism and transport ⁶⁶ The retinoid cycle in cones (daylight vision) ⁶⁶ Visual phototransduction ⁶⁶ Vitamin D (calciferol) metabolism ⁶⁶	12.06	CALM2 CALM1
2	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways B Cell Receptor Signaling Pathway ⁶⁷	12.06	CALM2 CALM1
3	cAMP signaling pathway ³⁷	12.06	CALM2 CALM1
4	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.05	CALM2 CALM1
5	Calcium signaling pathway ³⁷ Show member pathways Oxytocin signaling ¹	12.01	CALM2 CALM1
6	Platelet homeostasis ⁶⁶ Show member pathways Elevation of cytosolic Ca2+ levels ⁶⁶ Platelet calcium homeostasis ⁶⁶ Platelet sensitization by LDL ⁶⁶ Prostacyclin signalling through prostacyclin receptor ⁶⁶ Reduction of cytosolic Ca++ levels ⁶⁶	12	CALM2 CALM1
7	Post NMDA receptor activation events ⁶⁶ Show member pathways Activation of AMPA receptors ⁶⁶ Activation of CaMK IV ⁶⁶ Activation of NMDA receptor upon glutamate binding and postsynaptic events ⁶⁶ CaMK IV-mediated phosphorylation of CREB ⁶⁶ CREB phosphorylation through the activation of CaMKII ⁶⁶ CREB phosphorylation through the activation of CaMKK ⁶⁶ CREB phosphorylation through the activation of Ras ⁶⁶ Ras activation uopn Ca2+ infux through NMDA receptor ⁶⁶ RSK activation ⁶⁶ Unblocking of NMDA receptor, glutamate binding and activation ⁶⁶	11.98	CALM2 CALM1
8	Tuberculosis ³⁷	11.96	CALM2 CALM1
9	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	11.95	CALM2 CALM1
10	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ VEGFR2 mediated vascular permeability ⁶⁶	11.95	CALM2 CALM1
11	Long-term potentiation ³⁷ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁵	11.93	CALM2 CALM1
12	Salivary secretion ³⁷ Show member pathways Gastric acid secretion ³⁷	11.92	CALM2 CALM1
13	Cellular senescence (KEGG) ³⁷	11.9	CALM2 CALM1
14	ADP signalling through P2Y purinoceptor 1 ⁶⁶ Show member pathways Development Angiotensin signaling via beta-Arrestin ²² Signal amplification ⁶⁶ Thrombin signalling through proteinase activated receptors (PARs) ⁶⁶ Thromboxane signalling through TP receptor ⁶⁶	11.9	CALM2 CALM1
15	MicroRNAs in cardiomyocyte hypertrophy ¹ Show member pathways Cardiac Hypertrophic Response ¹	11.9	CALM2 CALM1
16	Phototransduction ³⁷ Show member pathways Activation of the phototransduction cascade ⁶⁶ Inactivation, recovery and regulation of the phototransduction cascade ⁶⁶ The phototransduction cascade ⁶⁶ Visual signal transduction- Cones ¹ Visual signal transduction- Rods ¹	11.89	CALM2 CALM1
17	Immune response Function of MEF2 in T lymphocytes ²² Show member pathways Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis ²²	11.86	CALM2 CALM1
18	Fluid shear stress and atherosclerosis ³⁷	11.83	CALM2 CALM1
19	Apelin signaling pathway ³⁷	11.82	CALM2 CALM1
20	Translation Translation regulation by Alpha-1 adrenergic receptors ²² Show member pathways Development Activation of ERK by Alpha-1 adrenergic receptors ²²	11.76	CALM2 CALM1
21	Amphetamine addiction ³⁷ Show member pathways Cocaine addiction ³⁷	11.74	CALM2 CALM1
22	Inositol phosphate metabolism ⁶⁶ Show member pathways D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis ¹ D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis ¹ inositol pyrophosphates biosynthesis ¹ myo-inositol de novo biosynthesis ¹ Synthesis of IP2, IP, and Ins in the cytosol ⁶⁶ Synthesis of IP3 and IP4 in the cytosol ⁶⁶ Synthesis of IPs in the nucleus ⁶⁶ Synthesis of pyrophosphates in the cytosol ⁶⁶	11.72	CALM2 CALM1
23	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers ⁶⁶ Show member pathways B-Cell Receptor Complex ⁶⁴ CD22 mediated BCR regulation ⁶⁶ CLEC7A (Dectin-1) induces NFAT activation ⁶⁶ FCERI mediated Ca+2 mobilization ⁶⁶	11.69	CALM2 CALM1
24	Glucagon signaling pathway ³⁷	11.68	CALM2 CALM1
25	ErbB1 downstream signaling ¹	11.66	CALM2 CALM1
26	Visual Cycle in Retinal Rods ⁶⁴	11.65	CALM2 CALM1
27	Development EPO-induced Jak-STAT pathway ²² Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.64	CALM2 CALM1
28	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling ²² Show member pathways DARPP-32 events ⁶⁶	11.61	CALM2 CALM1
29	Uptake and actions of bacterial toxins ⁶⁶ Show member pathways Intestinal infectious diseases ⁶⁶ Neurotoxicity of clostridium toxins ⁶⁶ Toxicity of botulinum toxin type A (BoNT/A) ⁶⁶ Toxicity of botulinum toxin type B (BoNT/B) ⁶⁶ Toxicity of botulinum toxin type C (BoNT/C) ⁶⁶ Toxicity of botulinum toxin type E (BoNT/E) ⁶⁶ Toxicity of botulinum toxin type G (BoNT/G) ⁶⁶ Toxicity of tetanus toxin (TeNT) ⁶⁶ Uptake and function of anthrax toxins ⁶⁶ Uptake and function of diphtheria toxin ⁶⁶	11.54	CALM2 CALM1
30	Pertussis ³⁷	11.52	CALM2 CALM1
31	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.51	CALM2 CALM1
32	Phase 0 - rapid depolarisation ⁶⁶ Show member pathways Phase 2 - plateau phase ⁶⁶	11.5	CALM2 CALM1
33	Signal transduction_Erk Interactions- Inhibition of Erk ²²	11.49	CALM2 CALM1
34	Renin secretion ³⁷	11.45	CALM2 CALM1
35	IL2 signaling events mediated by PI3K ¹ Show member pathways IL2 signaling events mediated by STAT5 ¹	11.44	CALM2 CALM1
36	Endochondral Ossification ¹	11.42	CALM2 CALM1
37	Translocation of GLUT4 to the plasma membrane ⁶⁶	11.39	CALM2 CALM1
38	Downstream signaling in naive CD8+ T cells ¹ Show member pathways Ras signaling in the CD4+ TCR pathway ¹	11.38	CALM2 CALM1
39	DNA damage_Role of Brca1 and Brca2 in DNA repair ²²	11.32	CALM2 CALM1
40	Transcriptional Regulatory Network in Embryonic Stem Cell ⁶⁴	11.31	CALM2 CALM1
41	Role of Calcineurin-dependent NFAT signaling in lymphocytes ¹	11.29	CALM2 CALM1
42	Cytoskeleton remodeling_RalA regulation pathway ²²	11.27	CALM2 CALM1
43	G13 Signaling Pathway ¹	11.19	CALM2 CALM1
44	Melatonin metabolism and effects ¹	11.14	CALM2 CALM1
45	Smooth Muscle Contraction ⁶⁶	11.11	CALM2 CALM1
46	Glycogen Metabolism ¹	11.1	CALM2 CALM1
47	Nur77 Signaling in T-Cell ⁶⁴	11.08	CALM2 CALM1
48	Endothelin Pathways ¹	11.06	CALM2 CALM1
49	Development_Thrombopoetin signaling via JAK-STAT pathway ²²	11.03	CALM2 CALM1
50	N-cadherin signaling events ¹	11.03	CALM2 CALM1

Sources

GO Terms for Long Qt Syndrome 15

Cellular components related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoskeleton	GO:0005856	9.63	CD2AP CALM2 CALM1
2	spindle	GO:0005819	9.48	CALM2 CALM1
3	vesicle	GO:0031982	9.43	CALM2 CALM1
4	protein-containing complex	GO:0032991	9.43	CD2AP CALM2 CALM1
5	myelin sheath	GO:0043209	9.4	CALM2 CALM1
6	spindle pole	GO:0000922	9.37	CALM2 CALM1
7	sarcomere	GO:0030017	9.32	CALM2 CALM1
8	spindle microtubule	GO:0005876	9.16	CALM2 CALM1
9	calcium channel complex	GO:0034704	8.96	CALM2 CALM1
10	catalytic complex	GO:1902494	8.62	CALM2 CALM1

Biological processes related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium-mediated signaling	GO:0019722	9.59	CALM2 CALM1
2	response to calcium ion	GO:0051592	9.58	CALM2 CALM1
3	positive regulation of protein serine/threonine kinase activity	GO:0071902	9.58	CALM2 CALM1
4	substantia nigra development	GO:0021762	9.57	CALM2 CALM1
5	regulation of cytokinesis	GO:0032465	9.56	CALM2 CALM1
6	regulation of heart rate	GO:0002027	9.55	CALM2 CALM1
7	positive regulation of peptidyl-threonine phosphorylation	GO:0010800	9.54	CALM2 CALM1
8	positive regulation of protein dephosphorylation	GO:0035307	9.52	CALM2 CALM1
9	positive regulation of protein autophosphorylation	GO:0031954	9.51	CALM2 CALM1
10	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:0010880	9.49	CALM2 CALM1
11	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	GO:0010881	9.48	CALM2 CALM1
12	regulation of cardiac muscle contraction	GO:0055117	9.46	CALM2 CALM1
13	positive regulation of phosphoprotein phosphatase activity	GO:0032516	9.43	CALM2 CALM1
14	negative regulation of peptidyl-threonine phosphorylation	GO:0010801	9.4	CALM2 CALM1
15	detection of calcium ion	GO:0005513	9.37	CALM2 CALM1
16	negative regulation of ryanodine-sensitive calcium-release channel activity	GO:0060315	9.32	CALM2 CALM1
17	regulation of cell communication by electrical coupling involved in cardiac conduction	GO:1901844	9.26	CALM2 CALM1
18	positive regulation of ryanodine-sensitive calcium-release channel activity	GO:0060316	9.16	CALM2 CALM1
19	positive regulation of cyclic-nucleotide phosphodiesterase activity	GO:0051343	8.96	CALM2 CALM1
20	positive regulation by host of symbiont cAMP-mediated signal transduction	GO:0075206	8.62	CALM2 CALM1

Molecular functions related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ion channel binding	GO:0044325	9.46	CALM2 CALM1
2	disordered domain specific binding	GO:0097718	9.43	CALM2 CALM1
3	protein serine/threonine kinase activator activity	GO:0043539	9.4	CALM2 CALM1
4	titin binding	GO:0031432	9.37	CALM2 CALM1
5	adenylate cyclase binding	GO:0008179	9.32	CALM2 CALM1
6	calcium channel inhibitor activity	GO:0019855	9.26	CALM2 CALM1
7	protein phosphatase activator activity	GO:0072542	9.16	CALM2 CALM1
8	adenylate cyclase activator activity	GO:0010856	8.96	CALM2 CALM1
9	N-terminal myristoylation domain binding	GO:0031997	8.62	CALM2 CALM1

Sources

Sources for Long Qt Syndrome 15

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia

Long Qt Syndrome 15 (LQT15)

Aliases & Classifications for Long Qt Syndrome 15

MalaCards integrated aliases for Long Qt Syndrome 15:

Characteristics:

OMIM:

HPO:

Classifications:

External Ids:

Summaries for Long Qt Syndrome 15

Related Diseases for Long Qt Syndrome 15

Diseases in the Long Qt Syndrome family:

Diseases related to Long Qt Syndrome 15 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Long Qt Syndrome 15:

Symptoms & Phenotypes for Long Qt Syndrome 15

Human phenotypes related to Long Qt Syndrome 15:

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

GenomeRNAi Phenotypes related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

Drugs & Therapeutics for Long Qt Syndrome 15

Genetic Tests for Long Qt Syndrome 15

Genetic tests related to Long Qt Syndrome 15:

Anatomical Context for Long Qt Syndrome 15

MalaCards organs/tissues related to Long Qt Syndrome 15:

Publications for Long Qt Syndrome 15

Articles related to Long Qt Syndrome 15:

Genes for Long Qt Syndrome 15

Genes related to Long Qt Syndrome 15 (1 elite genes):

Variations for Long Qt Syndrome 15

ClinVar genetic disease variations for Long Qt Syndrome 15:

UniProtKB/Swiss-Prot genetic disease variations for Long Qt Syndrome 15:

Expression for Long Qt Syndrome 15

Pathways for Long Qt Syndrome 15

Pathways related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

GO Terms for Long Qt Syndrome 15

Cellular components related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

Biological processes related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

Molecular functions related to Long Qt Syndrome 15 according to GeneCards Suite gene sharing:

Sources for Long Qt Syndrome 15