Aliases & Classifications for Longevity 1

MalaCards integrated aliases for Longevity 1:

Name: Longevity 1 57 70

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
possible monogenic influence at a relatively small number of loci


External Ids:

OMIM® 57 152430
UMLS 70 C2750617

Summaries for Longevity 1

OMIM® : 57 Longevity, or extended life span, is a complex trait, determined by multiple genes as well as by environmental factors. Longevity has been associated with a locus on chromosome 4 (LGV1). Longevity has also been associated with a locus on chromosome 6q21 (LGV2; 606460). See also 502000 for a discussion of aging related to changes in mitochondrial DNA. (152430) (Updated 05-Apr-2021)

MalaCards based summary : Longevity 1 An important gene associated with Longevity 1 is LGV1 (Longevity 1). Affiliated tissues include spinal cord.

Related Diseases for Longevity 1

Diseases in the Longevity 1 family:

Longevity 2

Symptoms & Phenotypes for Longevity 1

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Misc:
longevity

Clinical features from OMIM®:

152430 (Updated 05-Apr-2021)

Drugs & Therapeutics for Longevity 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Detection of Epigenome Variation Associated With Longevity Among the Multi Ethnic Centenarian Population in Israel Recruiting NCT03541460

Search NIH Clinical Center for Longevity 1

Genetic Tests for Longevity 1

Anatomical Context for Longevity 1

MalaCards organs/tissues related to Longevity 1:

40
Spinal Cord

Publications for Longevity 1

Articles related to Longevity 1:

(show all 38)
# Title Authors PMID Year
1
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. 57
21562563 2011
2
Hallmark features of immunosenescence are absent in familial longevity. 57
20855876 2010
3
Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. 57
19451219 2009
4
The quest for genetic determinants of human longevity: challenges and insights. 57
16708071 2006
5
Role of Toll-like receptor 4 in acute myocardial infarction and longevity. 57
15547160 2004
6
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. 57
15520384 2004
7
Unique lipoprotein phenotype and genotype associated with exceptional longevity. 57
14559957 2003
8
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. 57
12646697 2003
9
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. 57
12483296 2003
10
The emergence of humans: the coevolution of intelligence and longevity with intergenerational transfers. 57
12122210 2002
11
Life-long sustained mortality advantage of siblings of centenarians. 57
12060785 2002
12
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. 57
12082503 2002
13
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. 57
11526246 2001
14
Inheritance of human longevity in Iceland. 57
11039573 2000
15
Mitochondrial genotype associated with longevity. 57
9449878 1998
16
The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. 57
8786073 1996
17
Longevity is moderately heritable in a sample of Danish twins born 1870-1880. 57
8227991 1993
18
Prospects for the genetics of human longevity. 57
8340104 1993
19
Evolution of human longevity and the genetic complexity governing aging rate. 57
812099 1975
20
The familial component in longevity. A study of offspring of nonagenarians. II. Preliminary analysis of the completed study. 57
4809537 1974
21
Survival trends in a senescent twin population. 57
14406852 1960
22
Predicting survival and longevity of sows using purebred and crossbred data. 61
32705068 2020
23
Association between SIRT6 Methylation and Human Longevity in a Chinese Population. 61
33238266 2020
24
Genome-wide association study for longevity in the Holstein cattle population. 61
30501681 2019
25
Carotenoid-based coloration predicts both longevity and lifetime fecundity in male birds, but testosterone disrupts signal reliability. 61
31442265 2019
26
Systematic review of the clinical development of group B streptococcus serotype-specific capsular polysaccharide-based vaccines. 61
29961350 2018
27
The Hiroshima/Nagasaki Survivor Studies: Discrepancies Between Results and General Perception. 61
27516613 2016
28
Monitoring newly synthesized proteins over the adult life span of Caenorhabditis elegans. 61
25686393 2015
29
Macronutrient balance, reproductive function, and lifespan in aging mice. 61
25733862 2015
30
Russian translations for Cochrane. 61
26639688 2015
31
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. 61
22923132 2013
32
Cancer vaccines in the immunotherapy era: rational approach. 61
23831824 2013
33
[Longevity: 1. Social, clinical and some metabolic aspects]. 61
21510087 2010
34
Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin: systematic review and economic evaluation. 61
19331797 2009
35
[On human longevity--1. external influences]. 61
19642308 2009
36
DISPERSAL OF HORMOSIRA BANKSII (PHAEOPHYCEAE) VIA DETACHED FRAGMENTS: REPRODUCTIVE VIABILITY AND LONGEVITY(1). 61
27041707 2008
37
The use of valved conduits in pediatric cardiac surgery. 61
9636251 1998
38
Health habits in relation to aging. 61
701699 1978

Variations for Longevity 1

Expression for Longevity 1

Search GEO for disease gene expression data for Longevity 1.

Pathways for Longevity 1

GO Terms for Longevity 1

Sources for Longevity 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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