MCID: LNG066
MIFTS: 13

Longevity 1

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Aliases & Classifications for Longevity 1

MalaCards integrated aliases for Longevity 1:

Name: Longevity 1 57 71

Characteristics:


Inheritance:

Possible monogenic influence at a relatively small number of loci 57

External Ids:

OMIM® 57 152430
UMLS 71 C2750617

Summaries for Longevity 1

OMIM®: 57 Longevity, or extended life span, is a complex trait, determined by multiple genes as well as by environmental factors. Longevity has been associated with a locus on chromosome 4 (LGV1). Longevity has also been associated with a locus on chromosome 6q21 (LGV2; 606460). See also 502000 for a discussion of aging related to changes in mitochondrial DNA. (152430) (Updated 08-Dec-2022)

MalaCards based summary: Longevity 1 An important gene associated with Longevity 1 is LGV1 (Longevity 1). Affiliated tissues include spinal cord.

Related Diseases for Longevity 1

Diseases in the Longevity 1 family:

Longevity 2

Symptoms & Phenotypes for Longevity 1

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Misc:
longevity

Clinical features from OMIM®:

152430 (Updated 08-Dec-2022)

Drugs & Therapeutics for Longevity 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Detection of Epigenome Variation Associated With Longevity Among the Multi Ethnic Centenarian Population in Israel Recruiting NCT03541460
2 Dietary Habits and Lifestyle of Nonagenarians and Centenarians in the Italian Abruzzo Region Recruiting NCT04840381

Search NIH Clinical Center for Longevity 1

Genetic Tests for Longevity 1

Anatomical Context for Longevity 1

Organs/tissues related to Longevity 1:

MalaCards : Spinal Cord

Publications for Longevity 1

Articles related to Longevity 1:

(show all 39)
# Title Authors PMID Year
1
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. 57
21562563 2011
2
Hallmark features of immunosenescence are absent in familial longevity. 57
20855876 2010
3
Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. 57
19451219 2009
4
The quest for genetic determinants of human longevity: challenges and insights. 57
16708071 2006
5
Genetic influence on human lifespan and longevity. 57
16463022 2006
6
Role of Toll-like receptor 4 in acute myocardial infarction and longevity. 57
15547160 2004
7
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. 57
15520384 2004
8
Unique lipoprotein phenotype and genotype associated with exceptional longevity. 57
14559957 2003
9
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. 57
12646697 2003
10
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. 57
12483296 2003
11
The emergence of humans: the coevolution of intelligence and longevity with intergenerational transfers. 57
12122210 2002
12
Life-long sustained mortality advantage of siblings of centenarians. 57
12060785 2002
13
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. 57
12082503 2002
14
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. 57
11526246 2001
15
Inheritance of human longevity in Iceland. 57
11039573 2000
16
Mitochondrial genotype associated with longevity. 57
9449878 1998
17
The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. 57
8786073 1996
18
Longevity is moderately heritable in a sample of Danish twins born 1870-1880. 57
8227991 1993
19
Prospects for the genetics of human longevity. 57
8340104 1993
20
Evolution of human longevity and the genetic complexity governing aging rate. 57
812099 1975
21
The familial component in longevity. A study of offspring of nonagenarians. II. Preliminary analysis of the completed study. 57
4809537 1974
22
Survival trends in a senescent twin population. 57
14406852 1960
23
Predicting survival and longevity of sows using purebred and crossbred data. 62
32705068 2020
24
Association between SIRT6 Methylation and Human Longevity in a Chinese Population. 62
33238266 2020
25
Genome-wide association study for longevity in the Holstein cattle population. 62
30501681 2019
26
Carotenoid-based coloration predicts both longevity and lifetime fecundity in male birds, but testosterone disrupts signal reliability. 62
31442265 2019
27
Systematic review of the clinical development of group B streptococcus serotype-specific capsular polysaccharide-based vaccines. 62
29961350 2018
28
The Hiroshima/Nagasaki Survivor Studies: Discrepancies Between Results and General Perception. 62
27516613 2016
29
Macronutrient balance, reproductive function, and lifespan in aging mice. 62
25733862 2015
30
Monitoring newly synthesized proteins over the adult life span of Caenorhabditis elegans. 62
25686393 2015
31
Russian translations for Cochrane. 62
26639688 2015
32
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. 62
22923132 2013
33
Cancer vaccines in the immunotherapy era: rational approach. 62
23831824 2013
34
[Longevity: 1. Social, clinical and some metabolic aspects]. 62
21510087 2010
35
Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin: systematic review and economic evaluation. 62
19331797 2009
36
[On human longevity--1. external influences]. 62
19642308 2009
37
DISPERSAL OF HORMOSIRA BANKSII (PHAEOPHYCEAE) VIA DETACHED FRAGMENTS: REPRODUCTIVE VIABILITY AND LONGEVITY(1). 62
27041707 2008
38
The use of valved conduits in pediatric cardiac surgery. 62
9636251 1998
39
Health habits in relation to aging. 62
701699 1978

Variations for Longevity 1

Expression for Longevity 1

Search GEO for disease gene expression data for Longevity 1.

Pathways for Longevity 1

GO Terms for Longevity 1

Sources for Longevity 1

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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