LAHS
MCID: LSN002
MIFTS: 28

Loose Anagen Hair Syndrome (LAHS)

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Loose Anagen Hair Syndrome

MalaCards integrated aliases for Loose Anagen Hair Syndrome:

Name: Loose Anagen Hair Syndrome 58 77 54 76 74
Loose Anagen Syndrome 54 60
Loose Anagen Hair 30
Lahs 76

Characteristics:

Orphanet epidemiological data:

60
loose anagen syndrome
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy;

OMIM:

58
Inheritance:
autosomal dominant with variable expressivity


HPO:

33
loose anagen hair syndrome:
Onset and clinical course childhood onset juvenile onset


Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

OMIM 58 600628
MESH via Orphanet 46 D058247
ICD10 via Orphanet 35 L65.1
UMLS via Orphanet 75 C0406468
Orphanet 60 ORPHA168
MedGen 43 C0406468
SNOMED-CT via HPO 70 297995004
UMLS 74 C0406468

Summaries for Loose Anagen Hair Syndrome

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 168Disease definitionLoose anagen syndrome is a rare benign hair disorder affecting predominantly blond females in childhood and characterized by the presence of hair that can be easily and painlessly pulled out. Most of the hair is in the anagen phase and lacks an external epithelial sheath. Hair grows back quickly and the condition improves spontaneously with aging. Loose anagen hair can be associated with other anomalies, such as coloboma.Visit the Orphanet disease page for more resources.

MalaCards based summary : Loose Anagen Hair Syndrome, also known as loose anagen syndrome, is related to noonan syndrome-like disorder with loose anagen hair 2 and hypotrichosis 6. An important gene associated with Loose Anagen Hair Syndrome is KRT75 (Keratin 75). Affiliated tissues include skin, and related phenotypes are abnormal hair whorl and iris coloboma

UniProtKB/Swiss-Prot : 76 Loose anagen hair syndrome: In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.

Wikipedia : 77 Loose anagen syndrome (also known as "Loose anagen hair syndrome") is primarily described in fair-haired... more...

Description from OMIM: 600628

Related Diseases for Loose Anagen Hair Syndrome

Graphical network of the top 20 diseases related to Loose Anagen Hair Syndrome:



Diseases related to Loose Anagen Hair Syndrome

Symptoms & Phenotypes for Loose Anagen Hair Syndrome

Human phenotypes related to Loose Anagen Hair Syndrome:

60 33 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal hair whorl 60 33 hallmark (90%) Very frequent (99-80%) HP:0010721
2 iris coloboma 60 33 frequent (33%) Frequent (79-30%) HP:0000612
3 abnormality of the hair 60 Very frequent (99-80%)
4 sparse hair 33 HP:0008070
5 fair hair 33 HP:0002286
6 loose anagen hair 33 HP:0040169

Symptoms via clinical synopsis from OMIM:

58
Misc:
childhood onset

Lab:
hair shafts of reduced caliber
slight flattening and longitudinal grooving of hair on em

Hair:
loose actively growing hair
relatively sparse short hair
fair colored hair
hairs not fragile

Clinical features from OMIM:

600628

Drugs & Therapeutics for Loose Anagen Hair Syndrome

Search Clinical Trials , NIH Clinical Center for Loose Anagen Hair Syndrome

Genetic Tests for Loose Anagen Hair Syndrome

Genetic tests related to Loose Anagen Hair Syndrome:

# Genetic test Affiliating Genes
1 Loose Anagen Hair 30

Anatomical Context for Loose Anagen Hair Syndrome

MalaCards organs/tissues related to Loose Anagen Hair Syndrome:

42
Skin

Publications for Loose Anagen Hair Syndrome

Articles related to Loose Anagen Hair Syndrome:

(show all 32)
# Title Authors Year
1
Loose anagen hair syndrome: Treatment with systemic minoxidil characterised by marked hair colour change. ( 29566258 )
2018
2
Loose Anagen Hair Syndrome. ( 29705113 )
2018
3
Loose anagen hair syndrome: Is there any association with atopic dermatitis? ( 26955589 )
2016
4
Loose Anagen Syndrome: A Retrospective Chart Review of 37 Cases. ( 27436070 )
2016
5
Trichoscopy findings in loose anagen hair syndrome: rectangular granular structures and solitary yellow dots. ( 25932055 )
2015
6
Loose Anagen Hair Syndrome. ( 26622162 )
2015
7
A case of loose anagen syndrome in an African American girl. ( 25779929 )
2015
8
Minoxidil 5% solution for topical treatment of loose anagen hair syndrome. ( 24602086 )
2014
9
Loose anagen hair syndrome. ( 25396165 )
2014
10
Loose anagen hair syndrome in black-haired Indian children. ( 23937400 )
2013
11
Loose anagen hair syndrome in two patients with epidermolysis bullosa simplex, Dowling-Meara type. ( 22890742 )
2012
12
Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: an ultrastructural study. ( 21167408 )
2011
13
Loose anagen hair syndrome: an underdiagnosed condition in males. ( 20653870 )
2010
14
Loose anagen hair syndrome. ( 21712911 )
2010
15
Practical guidelines for evaluation of loose anagen hair syndrome. ( 19841399 )
2009
16
Loose anagen hair syndrome in children of Upper Egypt. ( 19527333 )
2009
17
Loose anagen hair syndrome: an unusual cause of alopecia of cosmetic importance only. ( 19735522 )
2009
18
Report of a new case with loose anagen hair syndrome and scanning electron microscopy findings. ( 18937657 )
2008
19
A girl with loose anagen hair syndrome and uncombable, spun-glass hair. ( 15916571 )
2005
20
Loose anagen hair syndrome associated with colobomas and dysmorphic features. ( 15127762 )
2004
21
Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study. ( 11939812 )
2002
22
Loose anagen hair syndrome and loose anagen hair. ( 11939815 )
2002
23
Loose anagen syndrome: a prospective study of three families. ( 11982568 )
2002
24
Loose anagen syndrome. ( 10439228 )
1999
25
Loose anagen hair syndrome mimicking the uncombable hair syndrome. ( 8646855 )
1996
26
An objective measurement of the anchoring strength of anagen hair in an adult with the loose anagen hair syndrome. ( 8793667 )
1996
27
Loose anagen syndrome and loose anagen hair. ( 9238333 )
1996
28
Loose anagen syndrome. ( 7763222 )
1995
29
Picture of the month. Loose anagen syndrome. ( 7795777 )
1995
30
Loose anagen syndrome: a new case. ( 7701886 )
1994
31
Loose anagen hair syndrome. ( 1559732 )
1992
32
Loose anagen syndrome. ( 2915060 )
1989

Variations for Loose Anagen Hair Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Loose Anagen Hair Syndrome:

76
# Symbol AA change Variation ID SNP ID
1 KRT75 p.Glu337Lys VAR_038104 rs2232398

Expression for Loose Anagen Hair Syndrome

Search GEO for disease gene expression data for Loose Anagen Hair Syndrome.

Pathways for Loose Anagen Hair Syndrome

GO Terms for Loose Anagen Hair Syndrome

Sources for Loose Anagen Hair Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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