LAHS
MCID: LSN002
MIFTS: 27

Loose Anagen Hair Syndrome (LAHS)

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Loose Anagen Hair Syndrome

MalaCards integrated aliases for Loose Anagen Hair Syndrome:

Name: Loose Anagen Hair Syndrome 58 77 54 76 74
Loose Anagen Syndrome 54 60
Lahs 76

Characteristics:

Orphanet epidemiological data:

60
loose anagen syndrome
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy;

OMIM:

58
Inheritance:
autosomal dominant with variable expressivity


HPO:

33
loose anagen hair syndrome:
Onset and clinical course childhood onset juvenile onset
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

OMIM 58 600628
MESH via Orphanet 46 D058247
ICD10 via Orphanet 35 L65.1
UMLS via Orphanet 75 C0406468
Orphanet 60 ORPHA168
MedGen 43 C0406468
SNOMED-CT via HPO 70 263681008 297995004
UMLS 74 C0406468

Summaries for Loose Anagen Hair Syndrome

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 168Disease definitionLoose anagen syndrome is a rare benign hair disorder affecting predominantly blond females in childhood and characterized by the presence of hair that can be easily and painlessly pulled out. Most of the hair is in the anagen phase and lacks an external epithelial sheath. Hair grows back quickly and the condition improves spontaneously with aging. Loose anagen hair can be associated with other anomalies, such as coloboma.Visit the Orphanet disease page for more resources.

MalaCards based summary : Loose Anagen Hair Syndrome, also known as loose anagen syndrome, is related to hypotrichosis 6 and hypotrichosis 7. An important gene associated with Loose Anagen Hair Syndrome is KRT75 (Keratin 75). Affiliated tissues include skin, eye and t cells, and related phenotypes are abnormal hair whorl and iris coloboma

UniProtKB/Swiss-Prot : 76 Loose anagen hair syndrome: In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.

Wikipedia : 77 Loose anagen syndrome is primarily described in fair-haired children who have easily dislodgable... more...

Description from OMIM: 600628

Related Diseases for Loose Anagen Hair Syndrome

Diseases related to Loose Anagen Hair Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 hypotrichosis 6 11.7
2 hypotrichosis 7 11.4
3 noonan syndrome-like disorder with loose anagen hair 1 11.4
4 marie unna congenital hypotrichosis 11.3
5 hypotrichosis 8 11.1
6 epidermolysis bullosa simplex, dowling-meara type 10.2
7 uncombable hair syndrome 1 10.2
8 dermatitis, atopic 10.2
9 alopecia 10.2
10 dermatitis 10.2
11 epidermolysis bullosa 10.2
12 epidermolysis bullosa simplex 10.2
13 coloboma of macula 10.1
14 trichotillomania 10.1
15 diabetes mellitus, noninsulin-dependent 10.0
16 fish-eye disease 10.0
17 mycosis fungoides 10.0
18 netherton syndrome 10.0
19 epilepsy, idiopathic generalized 10.0
20 tick-borne encephalitis 10.0
21 lymphoma 10.0
22 cutaneous t cell lymphoma 10.0
23 epilepsy 10.0
24 hypotrichosis 10.0
25 sezary's disease 10.0
26 encephalitis 10.0
27 growth hormone deficiency 10.0

Graphical network of the top 20 diseases related to Loose Anagen Hair Syndrome:



Diseases related to Loose Anagen Hair Syndrome

Symptoms & Phenotypes for Loose Anagen Hair Syndrome

Human phenotypes related to Loose Anagen Hair Syndrome:

60 33 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal hair whorl 60 33 hallmark (90%) Very frequent (99-80%) HP:0010721
2 iris coloboma 60 33 frequent (33%) Frequent (79-30%) HP:0000612
3 abnormality of the hair 60 Very frequent (99-80%)
4 sparse hair 33 HP:0008070
5 fair hair 33 HP:0002286
6 loose anagen hair 33 HP:0040169

Symptoms via clinical synopsis from OMIM:

58
Misc:
childhood onset

Lab:
hair shafts of reduced caliber
slight flattening and longitudinal grooving of hair on em

Hair:
loose actively growing hair
relatively sparse short hair
fair colored hair
hairs not fragile

Clinical features from OMIM:

600628

Drugs & Therapeutics for Loose Anagen Hair Syndrome

Search Clinical Trials , NIH Clinical Center for Loose Anagen Hair Syndrome

Genetic Tests for Loose Anagen Hair Syndrome

Anatomical Context for Loose Anagen Hair Syndrome

MalaCards organs/tissues related to Loose Anagen Hair Syndrome:

42
Skin, Eye, T Cells

Publications for Loose Anagen Hair Syndrome

Articles related to Loose Anagen Hair Syndrome:

(show all 35)
# Title Authors Year
1
Loose Anagen Syndrome: A Little Response to Minoxidil. ( 31007480 )
2019
2
Loose anagen hair syndrome: Treatment with systemic minoxidil characterised by marked hair colour change. ( 29566258 )
2018
3
Loose Anagen Hair Syndrome. ( 29705113 )
2018
4
Loose anagen hair syndrome: Is there any association with atopic dermatitis? ( 26955589 )
2016
5
Loose Anagen Syndrome: A Retrospective Chart Review of 37 Cases. ( 27436070 )
2016
6
Trichoscopy findings in loose anagen hair syndrome: rectangular granular structures and solitary yellow dots. ( 25932055 )
2015
7
Loose Anagen Hair Syndrome. ( 26622162 )
2015
8
A case of loose anagen syndrome in an African American girl. ( 25779929 )
2015
9
Minoxidil 5% solution for topical treatment of loose anagen hair syndrome. ( 24602086 )
2014
10
Loose anagen hair syndrome. ( 25396165 )
2014
11
Loose anagen hair syndrome in black-haired Indian children. ( 23937400 )
2013
12
Loose anagen hair syndrome in two patients with epidermolysis bullosa simplex, Dowling-Meara type. ( 22890742 )
2012
13
Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: an ultrastructural study. ( 21167408 )
2011
14
Loose anagen hair syndrome: an underdiagnosed condition in males. ( 20653870 )
2010
15
Loose anagen hair syndrome. ( 21712911 )
2010
16
Loose anagen hair syndrome: an unusual cause of alopecia of cosmetic importance only. ( 19735522 )
2009
17
Loose anagen hair syndrome in children of Upper Egypt. ( 19527333 )
2009
18
Practical guidelines for evaluation of loose anagen hair syndrome. ( 19841399 )
2009
19
Report of a new case with loose anagen hair syndrome and scanning electron microscopy findings. ( 18937657 )
2008
20
A girl with loose anagen hair syndrome and uncombable, spun-glass hair. ( 15916571 )
2005
21
Loose anagen hair syndrome associated with colobomas and dysmorphic features. ( 15127762 )
2004
22
Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study. ( 11939812 )
2002
23
Loose anagen hair syndrome and loose anagen hair. ( 11939815 )
2002
24
Loose anagen syndrome as a severity factor for trichotillomania. ( 12366432 )
2002
25
Loose anagen syndrome: a prospective study of three families. ( 11982568 )
2002
26
Loose anagen syndrome. ( 10439228 )
1999
27
Loose anagen hair syndrome mimicking the uncombable hair syndrome. ( 8646855 )
1996
28
An objective measurement of the anchoring strength of anagen hair in an adult with the loose anagen hair syndrome. ( 8793667 )
1996
29
Loose anagen syndrome and loose anagen hair. ( 9238333 )
1996
30
New familial association between ocular coloboma and loose anagen syndrome. ( 7628125 )
1995
31
Loose anagen syndrome. ( 7763222 )
1995
32
Picture of the month. Loose anagen syndrome. ( 7795777 )
1995
33
Loose anagen syndrome: a new case. ( 7701886 )
1994
34
Loose anagen hair syndrome. ( 1559732 )
1992
35
Loose anagen syndrome. ( 2915060 )
1989

Variations for Loose Anagen Hair Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Loose Anagen Hair Syndrome:

76
# Symbol AA change Variation ID SNP ID
1 KRT75 p.Glu337Lys VAR_038104 rs2232398

Expression for Loose Anagen Hair Syndrome

Search GEO for disease gene expression data for Loose Anagen Hair Syndrome.

Pathways for Loose Anagen Hair Syndrome

GO Terms for Loose Anagen Hair Syndrome

Sources for Loose Anagen Hair Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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