MCID: LSN002
MIFTS: 26

Loose Anagen Hair Syndrome

Categories: Rare diseases, Genetic diseases, Skin diseases

Aliases & Classifications for Loose Anagen Hair Syndrome

MalaCards integrated aliases for Loose Anagen Hair Syndrome:

Name: Loose Anagen Hair Syndrome 57 76 53 75 73
Loose Anagen Syndrome 53 59
Loose Anagen Hair 29
Lahs 75

Characteristics:

Orphanet epidemiological data:

59
loose anagen syndrome
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy;

OMIM:

57
Inheritance:
autosomal dominant with variable expressivity


HPO:

32
loose anagen hair syndrome:
Onset and clinical course juvenile onset childhood onset


Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

OMIM 57 600628
Orphanet 59 ORPHA168
UMLS via Orphanet 74 C0406468
MESH via Orphanet 45 D058247
ICD10 via Orphanet 34 L65.1
MedGen 42 C0406468
SNOMED-CT via HPO 69 297995004
UMLS 73 C0406468

Summaries for Loose Anagen Hair Syndrome

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 168Disease definitionLoose anagen syndrome is a rare benign hair disorder affecting predominantly blond females in childhood and characterized by the presence of hair that can be easily and painlessly pulled out. Most of the hair is in the anagen phase and lacks an external epithelial sheath. Hair grows back quickly and the condition improves spontaneously with aging. Loose anagen hair can be associated with other anomalies, such as coloboma.Visit the Orphanet disease page for more resources.

MalaCards based summary : Loose Anagen Hair Syndrome, also known as loose anagen syndrome, is related to hypotrichosis 6 and noonan syndrome-like disorder with loose anagen hair 1. An important gene associated with Loose Anagen Hair Syndrome is KRT75 (Keratin 75). Affiliated tissues include skin, and related phenotypes are iris coloboma and abnormal hair whorl

UniProtKB/Swiss-Prot : 75 Loose anagen hair syndrome: In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.

Wikipedia : 76 Loose anagen syndrome (also known as \"Loose anagen hair syndrome\") is primarily described in... more...

Description from OMIM: 600628

Related Diseases for Loose Anagen Hair Syndrome

Diseases related to Loose Anagen Hair Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 hypotrichosis 6 11.5
2 noonan syndrome-like disorder with loose anagen hair 1 11.2
3 marie unna congenital hypotrichosis 11.1
4 epidermolysis bullosa simplex, dowling-meara type 10.1
5 uncombable hair syndrome 1 10.1
6 dermatitis, atopic 10.1
7 alopecia 10.1
8 dermatitis 10.1
9 epidermolysis bullosa 10.1
10 epidermolysis bullosa simplex 10.1
11 trichotillomania 10.0

Graphical network of the top 20 diseases related to Loose Anagen Hair Syndrome:



Diseases related to Loose Anagen Hair Syndrome

Symptoms & Phenotypes for Loose Anagen Hair Syndrome

Symptoms via clinical synopsis from OMIM:

57
Hair:
loose actively growing hair
relatively sparse short hair
fair colored hair
hairs not fragile

Lab:
hair shafts of reduced caliber
slight flattening and longitudinal grooving of hair on em

Misc:
childhood onset


Clinical features from OMIM:

600628

Human phenotypes related to Loose Anagen Hair Syndrome:

59 32 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 iris coloboma 59 32 frequent (33%) Frequent (79-30%) HP:0000612
2 abnormal hair whorl 59 32 hallmark (90%) Very frequent (99-80%) HP:0010721
3 abnormality of the hair 59 Very frequent (99-80%)
4 fair hair 32 HP:0002286
5 sparse hair 32 HP:0008070
6 loose anagen hair 32 HP:0040169

Drugs & Therapeutics for Loose Anagen Hair Syndrome

Search Clinical Trials , NIH Clinical Center for Loose Anagen Hair Syndrome

Genetic Tests for Loose Anagen Hair Syndrome

Genetic tests related to Loose Anagen Hair Syndrome:

# Genetic test Affiliating Genes
1 Loose Anagen Hair 29

Anatomical Context for Loose Anagen Hair Syndrome

MalaCards organs/tissues related to Loose Anagen Hair Syndrome:

41
Skin

Publications for Loose Anagen Hair Syndrome

Articles related to Loose Anagen Hair Syndrome:

(show all 23)
# Title Authors Year
1
Loose anagen hair syndrome: Treatment with systemic minoxidil characterised by marked hair colour change. ( 29566258 )
2018
2
Loose Anagen Hair Syndrome. ( 29705113 )
2018
3
Loose anagen hair syndrome: Is there any association with atopic dermatitis? ( 26955589 )
2016
4
Trichoscopy findings in loose anagen hair syndrome: rectangular granular structures and solitary yellow dots. ( 25932055 )
2015
5
Loose Anagen Hair Syndrome. ( 26622162 )
2015
6
Minoxidil 5% solution for topical treatment of loose anagen hair syndrome. ( 24602086 )
2014
7
Loose anagen hair syndrome. ( 25396165 )
2014
8
Loose anagen hair syndrome in black-haired Indian children. ( 23937400 )
2013
9
Loose anagen hair syndrome in two patients with epidermolysis bullosa simplex, Dowling-Meara type. ( 22890742 )
2012
10
Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: an ultrastructural study. ( 21167408 )
2011
11
Loose anagen hair syndrome: an underdiagnosed condition in males. ( 20653870 )
2010
12
Loose anagen hair syndrome. ( 21712911 )
2010
13
Practical guidelines for evaluation of loose anagen hair syndrome. ( 19841399 )
2009
14
Loose anagen hair syndrome in children of Upper Egypt. ( 19527333 )
2009
15
Loose anagen hair syndrome: an unusual cause of alopecia of cosmetic importance only. ( 19735522 )
2009
16
Report of a new case with loose anagen hair syndrome and scanning electron microscopy findings. ( 18937657 )
2008
17
A girl with loose anagen hair syndrome and uncombable, spun-glass hair. ( 15916571 )
2005
18
Loose anagen hair syndrome associated with colobomas and dysmorphic features. ( 15127762 )
2004
19
Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study. ( 11939812 )
2002
20
Loose anagen hair syndrome and loose anagen hair. ( 11939815 )
2002
21
Loose anagen hair syndrome mimicking the uncombable hair syndrome. ( 8646855 )
1996
22
An objective measurement of the anchoring strength of anagen hair in an adult with the loose anagen hair syndrome. ( 8793667 )
1996
23
Loose anagen hair syndrome. ( 1559732 )
1992

Variations for Loose Anagen Hair Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Loose Anagen Hair Syndrome:

75
# Symbol AA change Variation ID SNP ID
1 KRT75 p.Glu337Lys VAR_038104 rs2232398

Expression for Loose Anagen Hair Syndrome

Search GEO for disease gene expression data for Loose Anagen Hair Syndrome.

Pathways for Loose Anagen Hair Syndrome

GO Terms for Loose Anagen Hair Syndrome

Sources for Loose Anagen Hair Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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