MCID: LSB001
MIFTS: 39

Louse-Borne Relapsing Fever

Categories: Infectious diseases

Aliases & Classifications for Louse-Borne Relapsing Fever

MalaCards integrated aliases for Louse-Borne Relapsing Fever:

Name: Louse-Borne Relapsing Fever 12 3 15 73
Relapsing Fever, Louse-Borne 12 3

Classifications:



External Ids:

Disease Ontology 12 DOID:13035
ICD10 33 A68.0
ICD9CM 35 087.0
SNOMED-CT 68 14683004
UMLS 73 C0152061

Summaries for Louse-Borne Relapsing Fever

Disease Ontology : 12 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted by body louse (Pediculus humanus). The infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Louse-Borne Relapsing Fever, also known as relapsing fever, louse-borne, is related to relapsing fever and meningitis, and has symptoms including tachypnea, tachycardia and hepatosplenomegaly. An important gene associated with Louse-Borne Relapsing Fever is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Affiliated tissues include heart, and related phenotype is Reduced mammosphere formation.

CDC : 3 Soldiers in World War I search for lice. (Image from the Library of Medicine/History of Medicine collection.)

Related Diseases for Louse-Borne Relapsing Fever

Diseases related to Louse-Borne Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 relapsing fever 33.1 ARSI CRP TNF
2 meningitis 29.1 CRP CXCL8 IL6 TNF
3 pediculus humanus corporis infestation 11.3
4 melancholia 10.7 CRP TNF
5 melkersson-rosenthal syndrome 10.7 SERPING1 TNF
6 acquired angioedema 10.6 CRP SERPING1
7 epididymitis 10.5 ARSI CRP
8 tungiasis 10.4 CXCL8 TNF
9 slow-channel congenital myasthenic syndrome 10.4 CRP CXCL8
10 pyuria 10.3 CRP CXCL8
11 scorpion envenomation 10.2 IL6 TNF
12 trichuriasis 10.2 CXCL8 TNF
13 haemophilus influenzae 10.2 CXCL8 TNF
14 pleurisy 10.2 CRP CXCL8 TNF
15 cold agglutinin disease 10.2 CRP IL6
16 leukomalacia 10.2 IL6 TNF
17 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
18 pulmonary edema 10.2 CRP CXCL8 TNF
19 cardiac rupture 10.2 CRP CXCL8
20 critical limb ischemia 10.2 IL6 TNF
21 null-cell leukemia 10.1 IL6 TNF
22 cryopyrin-associated periodic syndrome 10.1 CRP IL6
23 cardiogenic shock 10.1 CRP IL6
24 visceral leishmaniasis 10.1 CRP CXCL8 TNF
25 malaria 10.1
26 epidemic typhus 10.1
27 syphilis 10.1
28 acute cholangitis 10.1 CRP IL6
29 retinitis pigmentosa 55 10.1 IL6 TNF
30 respiratory failure 10.1 CRP CXCL8 TNF
31 neutrophilia, hereditary 10.1 CRP IL6
32 macular degeneration, age-related, 1 10.1 CFHR1 CRP SERPING1 TNF
33 anca-associated vasculitis 10.1 IL6 TNF
34 clonorchiasis 10.1 CXCL8 TNF
35 uremic pruritus 10.1 CRP IL6
36 spinal disease 10.0 CRP IL6
37 castleman disease 10.0 CRP IL6
38 laryngitis 10.0 IL6 TNF
39 central nervous system vasculitis 10.0 CRP IL6 TNF
40 ischemic heart disease 10.0 CRP IL6 TNF
41 systolic heart failure 10.0 CRP IL6 TNF
42 apnea, obstructive sleep 10.0 CRP IL6 TNF
43 adult-onset still's disease 10.0 CRP IL6 TNF
44 infective endocarditis 10.0 CRP IL6 TNF
45 hemorrhagic fever with renal syndrome 10.0 CRP IL6 TNF
46 lymph node disease 10.0 CRP IL6 TNF
47 exanthem 10.0 CRP IL6 TNF
48 pancreas disease 10.0 CRP IL6 TNF
49 pericarditis 10.0 CRP IL6 TNF
50 reactive arthritis 10.0 CRP IL6 TNF

Graphical network of the top 20 diseases related to Louse-Borne Relapsing Fever:



Diseases related to Louse-Borne Relapsing Fever

Symptoms & Phenotypes for Louse-Borne Relapsing Fever

Symptoms:

12
  • tachypnea
  • tachycardia
  • hepatosplenomegaly
  • lymphadenopathy

GenomeRNAi Phenotypes related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CFHR1 CXCL8 GAB2 MAPK1 RAD51 SERPING1

Drugs & Therapeutics for Louse-Borne Relapsing Fever

Search Clinical Trials , NIH Clinical Center for Louse-Borne Relapsing Fever

Genetic Tests for Louse-Borne Relapsing Fever

Anatomical Context for Louse-Borne Relapsing Fever

MalaCards organs/tissues related to Louse-Borne Relapsing Fever:

41
Heart

Publications for Louse-Borne Relapsing Fever

Articles related to Louse-Borne Relapsing Fever:

(show top 50) (show all 71)
# Title Authors Year
1
Outbreak of Louse-Borne Relapsing Fever among Urban Dwellers in Arsi Zone, Central Ethiopia, from July to November 2016. ( 29692298 )
2018
2
Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa. ( 29016302 )
2017
3
Louse-borne relapsing fever in Finland in two asylum seekers from Somalia. ( 27859692 )
2017
4
Louse-borne relapsing fever in a refugee from Mali. ( 28161771 )
2017
5
Louse-Borne Relapsing Fever (Borrelia recurrentis) in a Somali Refugee Arriving in Italy: A Re-emerging Infection in Europe? ( 27149282 )
2016
6
Louse-borne relapsing fever among East African refugees in Europe. ( 26872415 )
2016
7
Fourth case of louse-borne relapsing fever in Young Migrant, Sicily, Italy, December 2015. Mini Review Article. ( 27340042 )
2016
8
Louse-borne relapsing fever - report of four cases in Switzerland, June-December 2015. ( 27188655 )
2016
9
Louse-borne relapsing fever in a refugee from Somalia arriving in Belgium. ( 27356309 )
2016
10
Louse-Borne Relapsing Fever with Meningeal Involvement in an Immigrant from Somalia to Italy, October 2015. ( 26938933 )
2016
11
Louse-borne relapsing fever (Borrelia recurrentis) in an Eritrean refugee arriving in Switzerland, August 2015. ( 26290486 )
2015
12
Louse-borne relapsing fever (Borrelia recurrentis) in asylum seekers from Eritrea, the Netherlands, July 2015. ( 26250069 )
2015
13
Louse-borne relapsing fever (Borrelia recurrentis) diagnosed in 15 refugees from northeast Africa: epidemiology and preventive control measures, Bavaria, Germany, July to October 2015. ( 26538532 )
2015
14
Prevalence and risk factors of louse-borne relapsing fever in high risk populations in Bahir Dar city Northwest, Ethiopia. ( 25196787 )
2014
15
Louse-borne relapsing fever profile at Felegehiwot referral hospital, Bahir Dar city, Ethiopia: a retrospective study. ( 24742342 )
2014
16
Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis. ( 21803390 )
2011
17
Louse-borne relapsing fever in Ethiopian children: experience of a rural hospital. ( 19211422 )
2009
18
A novel animal model of Borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice. ( 19787030 )
2009
19
Results of a 10-year survey of louse-borne relapsing fever in southern Ethiopia: a decline in endemicity. ( 18577339 )
2008
20
The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii. ( 18787695 )
2008
21
Louse-borne relapsing fever and malaria co-infection in Ethiopia. ( 17540107 )
2007
22
Characteristics of louse-borne relapsing fever in Ethiopian children and adults. ( 15035729 )
2004
23
Serodiagnosis of Louse-Borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis. ( 11015364 )
2000
24
Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever. ( 9846580 )
1998
25
The effect of antibody against TNF alpha on cytokine response in Jarisch-Herxheimer reactions of louse-borne relapsing fever. ( 9093599 )
1997
26
Outbreak of louse-borne relapsing fever in Jimma, south western Ethiopia. ( 8625865 )
1996
27
Tumour necrosis factor, interleukin-6 and C-reactive protein in patients with louse-borne relapsing fever in Ethiopia. ( 7741594 )
1995
28
Louse-borne relapsing fever in southern Sudan. ( 8594674 )
1995
29
Louse-borne relapsing fever and its treatment. ( 8592762 )
1995
30
Treatment of louse-borne relapsing fever with low dose penicillin or tetracycline: a clinical trial. ( 7784810 )
1995
31
Louse-borne relapsing fever. Giulio Borgnolo et al. Tropical and Geographical Medicine 1993;45(2):66-9. ( 7941015 )
1994
32
Louse-borne relapsing fever epidemic in Arssi Region, Ethiopia: a six months survey. ( 8337714 )
1993
33
Epidemic of louse-borne relapsing fever in Ethiopia. ( 7901534 )
1993
34
Louse-borne relapsing fever. A clinical and an epidemiological study of 389 patients in Asella Hospital, Ethiopia. ( 8511813 )
1993
35
Louse-borne relapsing fever in Ethiopian children: a clinical study. ( 7687113 )
1993
36
Louse-borne relapsing fever in children. ( 1597878 )
1992
37
Tetracycline versus penicillin in the treatment of louse-borne relapsing fever. ( 1396621 )
1992
38
Louse-borne relapsing fever in Ethiopia. ( 1681201 )
1991
39
Clinical presentation of louse-borne relapsing fever among Ethiopian refugees in northern Somalia. ( 3257078 )
1988
40
Louse borne relapsing fever (LBRF): mortality and frequency of Jarisch-Herxheimer reaction. ( 3116249 )
1987
41
Pathophysiology and immunology of the Jarisch-Herxheimer-like reaction in louse-borne relapsing fever: comparison of tetracycline and slow-release penicillin. ( 6842024 )
1983
42
Antibiotic treatment of louse-borne relapsing fever in Ethiopia: a report of 377 cases. ( 6625065 )
1983
43
Louse-borne relapsing fever in the Sudan. A historical review and a clinico-pathological study. ( 7423600 )
1980
44
Louse-borne relapsing fever: I. A clinical and laboratory study of 363 cases in the Sudan. ( 871032 )
1977
45
Louse-borne relapsing fever: II. Combined penicillin and tetracycline therapy in 160 Sudanese patients. ( 871033 )
1977
46
Bleeding in louse-borne relapsing fever in Ethiopia; clinical and laboratory features in 29 patients. ( 964178 )
1976
47
Louse-borne relapsing fever in man. ( 4811584 )
1974
48
Single-dose doxycycline treatment of louse-borne relapsing fever and epidemic typhus. ( 4143011 )
1974
49
Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. II. Pathology. ( 4217571 )
1974
50
Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. III. Crisis following therapy. ( 4217572 )
1974

Variations for Louse-Borne Relapsing Fever

Expression for Louse-Borne Relapsing Fever

Search GEO for disease gene expression data for Louse-Borne Relapsing Fever.

Pathways for Louse-Borne Relapsing Fever

Pathways related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 CXCL8 IL6 MAPK1 NFKBIA TNF
2
Show member pathways
12.82 GAB2 IL6 MAPK1 NFKBIA TNF
3
Show member pathways
12.81 CXCL8 IL6 MAPK1 NFKBIA TNF
4 12.76 CXCL8 IL6 MAPK1 NFKBIA RAD51
5
Show member pathways
12.71 CXCL8 IL6 MAPK1 NFKBIA TNF
6
Show member pathways
12.7 CXCL8 IL6 NFKBIA TNF
7
Show member pathways
12.54 GAB2 MAPK1 NFKBIA TNF
8
Show member pathways
12.51 IL6 MAPK1 NFKBIA RAD51 TNF
9
Show member pathways
12.46 CXCL8 IL6 MAPK1 NFKBIA TNF
10
Show member pathways
12.38 IL6 MAPK1 NFKBIA TNF
11
Show member pathways
12.3 GAB2 IL6 MAPK1 NFKBIA TNF
12
Show member pathways
12.21 CXCL8 IL6 MAPK1 NFKBIA TNF
13
Show member pathways
12.14 IL6 MAPK1 NFKBIA TNF
14
Show member pathways
12.13 CXCL8 IL6 MAPK1 NFKBIA TNF
15
Show member pathways
12.11 CXCL8 GAB2 MAPK1
16 12.11 CXCL8 IL6 MAPK1
17
Show member pathways
12.11 CXCL8 IL6 NFKBIA TNF
18 12.1 C4B CXCL8 IL6 TNF
19
Show member pathways
12.1 CXCL8 IL6 MAPK1 NFKBIA TNF
20
Show member pathways
12.08 CXCL8 IL6 MAPK1 NFKBIA TNF
21
Show member pathways
12.02 C4B CRP SERPING1
22 11.99 CXCL8 MAPK1 NFKBIA TNF
23
Show member pathways
11.98 IL6 MAPK1 NFKBIA
24
Show member pathways
11.97 GAB2 MAPK1 NFKBIA
25 11.97 GAB2 MAPK1 NFKBIA TNF
26 11.96 GAB2 MAPK1 TNF
27 11.94 CXCL8 IL6 TNF
28
Show member pathways
11.92 GAB2 MAPK1 NFKBIA
29
Show member pathways
11.92 IL6 NFKBIA TNF
30 11.92 CXCL8 IL6 MAPK1 TNF
31 11.9 CXCL8 IL6 MAPK1
32 11.86 IL6 MAPK1 NFKBIA TNF
33 11.85 CXCL8 IL6 TNF
34 11.84 CXCL8 NFKBIA TNF
35 11.83 CXCL8 MAPK1 NFKBIA
36
Show member pathways
11.83 CXCL8 IL6 NFKBIA
37
Show member pathways
11.82 CXCL8 MAPK1 NFKBIA
38 11.81 CXCL8 IL6 TNF
39 11.81 CXCL8 IL6 MAPK1 TNF
40
Show member pathways
11.78 CRP IL6 MAPK1
41 11.78 CXCL8 IL6 MAPK1
42
Show member pathways
11.76 CXCL8 MAPK1 NFKBIA
43 11.75 CXCL8 IL6 MAPK1
44 11.68 MAPK1 NFKBIA TNF
45 11.64 CXCL8 IL6 NFKBIA
46 11.63 CXCL8 MAPK1 NFKBIA
47 11.61 CXCL8 IL6 TNF
48 11.54 CXCL8 IL6 MAPK1
49 11.48 CXCL8 IL6 TNF
50 11.48 CXCL8 IL6 TNF

GO Terms for Louse-Borne Relapsing Fever

Cellular components related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 C4B CFHR1 CRP CXCL8 IL6 SERPING1
2 extracellular region GO:0005576 9.28 ARSI C4B CFHR1 CRP CXCL8 IL6

Biological processes related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.78 CRP IL6 MAPK1 TNF
2 complement activation, classical pathway GO:0006958 9.72 C4B CRP SERPING1
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 IL6 NFKBIA TNF
4 cellular response to lipopolysaccharide GO:0071222 9.69 CXCL8 IL6 TNF
5 cellular response to tumor necrosis factor GO:0071356 9.63 CXCL8 MAPK1 NFKBIA
6 cytokine-mediated signaling pathway GO:0019221 9.62 CXCL8 GAB2 IL6 TNF
7 regulation of complement activation GO:0030449 9.61 C4B CFHR1 SERPING1
8 positive regulation of leukocyte chemotaxis GO:0002690 9.56 CXCL8 IL6
9 inflammatory response GO:0006954 9.55 C4B CRP CXCL8 IL6 TNF
10 defense response to Gram-positive bacterium GO:0050830 9.54 CRP IL6 TNF
11 positive regulation of chemokine production GO:0032722 9.52 IL6 TNF
12 embryonic digestive tract development GO:0048566 9.49 CXCL8 TNF
13 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.4 CRP NFKBIA
14 opsonization GO:0008228 9.26 C4B CRP
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.13 MAPK1 NFKBIA TNF
16 negative regulation of lipid storage GO:0010888 8.92 CRP IL6 NFKBIA TNF

Molecular functions related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.44 ARSI C4B CFHR1 CRP CXCL8 GAB2

Sources for Louse-Borne Relapsing Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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