MCID: LSB001
MIFTS: 33

Louse-Borne Relapsing Fever

Categories: Infectious diseases
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Aliases & Classifications for Louse-Borne Relapsing Fever

MalaCards integrated aliases for Louse-Borne Relapsing Fever:

Name: Louse-Borne Relapsing Fever 11 14 71 31 33
Relapsing Fever, Louse-Borne 11 2
Relapsing Fever Due to Borrelia Recurrentis 33

Classifications:



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Disease Ontology 11 DOID:13035
ICD9CM 34 087.0
MeSH 43 D012061
NCIt 49 C128426
SNOMED-CT 68 14683004
ICD10 31 A68.0
ICD11 33 1379934125
UMLS 71 C0152061

Summaries for Louse-Borne Relapsing Fever

CDC: 2 LBRF is caused by a spiral-shaped bacteria, Borrelia recurrentis, which is transmitted from human to human by the body louse. LBRF outbreaks most commonly occur in conditions of overcrowding and social disruption. LBRF epidemics occurred frequently in Europe during the early 20th Century. Between 1919 and 1923, 13 million cases resulting in 5 million deaths occurred in the social upheaval that overtook Russia and eastern Europe. During World War II, a million cases occurred in North Africa. Today, LBRF causes sporadic illness and outbreaks in sub-Saharan Africa, particularly in regions affected by war and in refugee camps. LBRF is commonly found in Ethiopia, Sudan, Eritrea, and Somalia. Illness can be severe, with mortality of 30 to 70% in outbreaks.

MalaCards based summary: Louse-Borne Relapsing Fever, also known as relapsing fever, louse-borne, is related to relapsing fever and tick-borne relapsing fever, and has symptoms including tachycardia, tachypnea and lymphadenopathy. An important gene associated with Louse-Borne Relapsing Fever is C4B (Complement C4B (Chido Blood Group)), and among its related pathways/superpathways are Innate Immune System and Complement cascade. Affiliated tissues include heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and renal/urinary system

Disease Ontology: 11 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has material basis in Borrelia recurrentis, which is transmitted by body louse (Pediculus humanus). The infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

Related Diseases for Louse-Borne Relapsing Fever

Diseases related to Louse-Borne Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 relapsing fever 30.9 YBX3 CYP26A1 CFH C4B C4A C3
2 tick-borne relapsing fever 30.8 YBX3 TMEM115 SERPING1 CYP26A1 C4B C4A
3 lyme disease 30.3 YBX3 CFH C4A C3
4 pediculus humanus corporis infestation 11.4
5 exanthem 10.5
6 myocarditis 10.5
7 typhoid fever 10.4
8 ocular motor apraxia 10.2
9 malaria 10.2
10 epidemic typhus 10.2
11 disseminated intravascular coagulation 10.2
12 adult respiratory distress syndrome 10.2
13 pulmonary edema 10.2
14 bronchopneumonia 10.2
15 hypolipoproteinemia 10.2
16 plasmodium falciparum malaria 10.2
17 leptospirosis 10.2
18 splenic infarction 10.2
19 plague 10.2
20 syphilis 10.2
21 brain edema 10.2
22 severe combined immunodeficiency 10.2
23 leishmaniasis 10.2
24 visceral leishmaniasis 10.2
25 cytokine deficiency 10.2
26 splenomegaly 10.2
27 proliferative glomerulonephritis 10.2 CFH C3
28 juvenile dermatitis herpetiformis 10.2 C4B C4A
29 atypical hemolytic uremic syndrome with complement gene abnormality 10.1 CFH C3
30 c3 glomerulopathy 10.1 CFH C3
31 epilepsy, familial temporal lobe, 2 10.1 C4B C4A
32 central serous chorioretinopathy 10.1 CFH C4B
33 d-minus hemolytic uremic syndrome 10.1 CFH C3
34 monkeypox 10.1 C4B C4A
35 cataract 23, multiple types 10.1 CFH C3
36 acute poststreptococcal glomerulonephritis 10.1 CFH C3
37 immune-complex glomerulonephritis 10.0 CFH C3
38 chronic venous insufficiency 10.0 C4B C4A
39 retinal drusen 10.0 CFH C3
40 complement factor i deficiency 10.0 C4B C4A C3
41 hypersensitivity reaction type iii disease 10.0 C4B C4A C3
42 alpha-2-plasmin inhibitor deficiency 10.0 SERPING1 C4B C4A
43 afibrinogenemia, congenital 10.0 C4B C4A C3
44 histoplasmosis 10.0 CFH C3
45 aseptic meningitis 10.0 C4B C4A
46 systemic lupus erythematosus 16 10.0 C4A C1R
47 complement component 2 deficiency 10.0 CFH C4B C4A
48 iga glomerulonephritis 9.9 CFH C4A C3
49 acrodermatitis chronica atrophicans 9.9 YBX3 CYP26A1 C4B
50 angioedema, hereditary, 3 9.9 SERPING1 C1S

Graphical network of the top 20 diseases related to Louse-Borne Relapsing Fever:



Diseases related to Louse-Borne Relapsing Fever

Symptoms & Phenotypes for Louse-Borne Relapsing Fever

Symptoms:

11
  • tachycardia
  • tachypnea
  • lymphadenopathy
  • hepatosplenomegaly

GenomeRNAi Phenotypes related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

25 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.02 C4A C4B SERPING1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.02 CYP26A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.02 C4A C4B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-180 10.02 CYP26A1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.02 CYP26A1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-216 10.02 SERPING1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.02 CYP26A1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.02 SERPING1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.02 SERPING1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.02 C4A C4B SERPING1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-45 10.02 SERPING1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.02 SERPING1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.02 SERPING1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.02 C4A C4B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.02 C4A C4B

MGI Mouse Phenotypes related to Louse-Borne Relapsing Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.56 C3 C4A C4B CFH CYP26A1 SERPING1
2 digestive/alimentary MP:0005381 9.02 C3 C4A C4B CYP26A1 YBX3

Drugs & Therapeutics for Louse-Borne Relapsing Fever

Search Clinical Trials, NIH Clinical Center for Louse-Borne Relapsing Fever

Genetic Tests for Louse-Borne Relapsing Fever

Anatomical Context for Louse-Borne Relapsing Fever

Organs/tissues related to Louse-Borne Relapsing Fever:

MalaCards : Heart

Publications for Louse-Borne Relapsing Fever

Articles related to Louse-Borne Relapsing Fever:

(show top 50) (show all 124)
# Title Authors PMID Year
1
Bioactive phytocompounds against specific target proteins of Borrelia recurrentis responsible for louse-borne relapsing fever: Genomics and structural bioinformatics evidence. 62
36377635 2022
2
Historical overview and update on relapsing fever group Borrelia in Latin America. 62
35676728 2022
3
A Comparative Study of Body Lice and Bed Bugs Reveals Factors Potentially Involved in Differential Vector Competence for the Relapsing Fever Spirochete Borrelia recurrentis. 62
35384689 2022
4
Tick borne relapsing fever - a systematic review and analysis of the literature. 62
35171908 2022
5
Novel approaches for the serodiagnosis of louse-borne relapsing fever. 62
36204641 2022
6
Borreliae Part 2: Borrelia Relapsing Fever Group and Unclassified Borrelia. 62
34827110 2021
7
Simultaneous Detection and Differentiation of Clinically Relevant Relapsing Fever Borrelia with Semimultiplex Real-Time PCR. 62
33910966 2021
8
The First Immunocompetent Mouse Model of Strictly Human Pathogen, Borrelia recurrentis. 62
33875475 2021
9
Acute infection as cause of hospitalization of asylum-seeking children and adolescents in Stockholm, Sweden 2015-2016. 62
32974759 2021
10
Louse-borne relapsing fever-A systematic review and analysis of the literature: Part 2-Mortality, Jarisch-Herxheimer reaction, impact on pregnancy. 62
33705387 2021
11
Louse-borne relapsing fever-A systematic review and analysis of the literature: Part 1-Epidemiology and diagnostic aspects. 62
33705384 2021
12
Testing the Competence of Cimex lectularius Bed Bugs for the Transmission of Borrelia recurrentis, the Agent of Relapsing Fever. 62
30938280 2019
13
Louse-borne relapsing fever (Borrelia recurrentis infection). 62
30869050 2019
14
Genomic blueprint of a relapsing fever pathogen in 15th century Scandinavia. 62
30249639 2018
15
Infectious disease profiles of Syrian and Eritrean migrants presenting in Europe: A systematic review. 62
29702253 2018
16
Outbreak of Louse-Borne Relapsing Fever among Urban Dwellers in Arsi Zone, Central Ethiopia, from July to November 2016. 62
29692298 2018
17
Screening for infectious diseases among newly arrived asylum seekers, Bavaria, Germany, 2015. 62
29536830 2018
18
Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa. 62
29016302 2017
19
First insights in the variability of Borrelia recurrentis genomes. 62
28902847 2017
20
Louse-borne relapsing fever in a refugee from Mali. 62
28161771 2017
21
[A Somali refugee with fever and abnormal blood smear]. 62
27822621 2017
22
Louse-borne relapsing fever in Finland in two asylum seekers from Somalia. 62
27859692 2017
23
Fourth case of louse-borne relapsing fever in Young Migrant, Sicily, Italy, December 2015. Mini Review Article. 62
27340042 2016
24
[Louse-borne-relapsing-fever in refugees from the Horn of Africa; a case series of 25 patients]. 62
27404939 2016
25
[Relapsing fever: an almost forgotten disease in focus again]. 62
27404930 2016
26
Louse-Borne Relapsing Fever with Meningeal Involvement in an Immigrant from Somalia to Italy, October 2015. 62
26938933 2016
27
Louse-Borne Relapsing Fever (Borrelia recurrentis) in a Somali Refugee Arriving in Italy: A Re-emerging Infection in Europe? 62
27149282 2016
28
Louse-borne relapsing fever - report of four cases in Switzerland, June-December 2015. 62
27188655 2016
29
[European migrant crisis and reemergence of infections in Switzerland]. 62
27263151 2016
30
Louse-borne relapsing fever among East African refugees in Europe. 62
26872415 2016
31
Louse-borne relapsing fever in a refugee from Somalia arriving in Belgium. 62
27356309 2016
32
Louseborne Relapsing Fever among East African Refugees, Italy, 2015. 62
26812354 2016
33
High Prevalence of Infectious Diseases and Drug-Resistant Microorganisms in Asylum Seekers Admitted to Hospital; No Carbapenemase Producing Enterobacteriaceae until September 2015. 62
27144599 2016
34
Louse-borne relapsing fever (Borrelia recurrentis) in an Eritrean refugee arriving in Switzerland, August 2015. 62
26290486 2015
35
Louse-borne relapsing fever (Borrelia recurrentis) in asylum seekers from Eritrea, the Netherlands, July 2015. 62
26250069 2015
36
Louse-borne relapsing fever (Borrelia recurrentis) diagnosed in 15 refugees from northeast Africa: epidemiology and preventive control measures, Bavaria, Germany, July to October 2015. 62
26538532 2015
37
Real-time monitoring of disease progression in rhesus macaques infected with Borrelia turicatae by tick bite. 62
24879799 2014
38
Prevalence and risk factors of louse-borne relapsing fever in high risk populations in Bahir Dar city Northwest, Ethiopia. 62
25196787 2014
39
Louse-borne relapsing fever profile at Felegehiwot referral hospital, Bahir Dar city, Ethiopia: a retrospective study. 62
24742342 2014
40
Transmission dynamics of Borrelia turicatae from the arthropod vector. 62
24699275 2014
41
Borrelia recurrentis in head lice, Ethiopia. 62
23648147 2013
42
Louse and tick borne relapsing fevers. 62
23469636 2012
43
Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis. 62
21803390 2011
44
Does RecA have a role in Borrelia recurrentis? 62
20456459 2011
45
Population structure of East African relapsing fever Borrelia spp. 62
20587177 2010
46
Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. 62
20532227 2010
47
Relapsing fever--a forgotten disease revealed. 62
19886891 2010
48
A novel animal model of Borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice. 62
19787030 2009
49
New concepts for the old challenge of African relapsing fever borreliosis. 62
19489922 2009
50
Louse-borne relapsing fever in Ethiopian children: experience of a rural hospital. 62
19211422 2009

Variations for Louse-Borne Relapsing Fever

Expression for Louse-Borne Relapsing Fever

Search GEO for disease gene expression data for Louse-Borne Relapsing Fever.

Pathways for Louse-Borne Relapsing Fever

Pathways related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 SERPING1 CFH C4B C4A C3 C1S
2
Show member pathways
12.26 SERPING1 CFH C4B C4A C3 C1S
3
Show member pathways
12.19 C1R C1S C3 C4B CFH SERPING1
4
Show member pathways
12 C4B C4A C3
5 11.55 C4B C4A C3
6
Show member pathways
11.49 CFH C4B C4A C3 C1S C1R
7 11.4 C4B C4A C3
8
Show member pathways
11.2 SERPING1 CFH C4B C4A C3 C1S
9 11.1 C4B C1S C1R

GO Terms for Louse-Borne Relapsing Fever

Cellular components related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 SERPING1 CFH C4B C4A C3 C1S
2 extracellular space GO:0005615 9.77 SERPING1 CFH C4B C4A C3 C1S
3 blood microparticle GO:0072562 9.44 SERPING1 CFH C4B C4A C3 C1S

Biological processes related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.1 SERPING1 CFH C4B C4A C3 C1S
2 negative regulation of endopeptidase activity GO:0010951 9.97 SERPING1 C4B C4A C3
3 positive regulation of apoptotic cell clearance GO:2000427 9.73 C3 C4A C4B
4 complement activation, classical pathway GO:0006958 9.73 SERPING1 C4B C4A C3 C1S C1R
5 complement activation, alternative pathway GO:0006957 9.71 CFH C3
6 immune system process GO:0002376 9.7 SERPING1 CFH C4B C4A C3 C1S
7 complement activation GO:0006956 9.32 CFH C4B C4A C3 C1S C1R

Molecular functions related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 9.1 C4B C4A C3

Sources for Louse-Borne Relapsing Fever

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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