MCID: LSB001
MIFTS: 39

Louse-Borne Relapsing Fever

Categories: Infectious diseases

Aliases & Classifications for Louse-Borne Relapsing Fever

MalaCards integrated aliases for Louse-Borne Relapsing Fever:

Name: Louse-Borne Relapsing Fever 12 15 74 3
Relapsing Fever, Louse-Borne 12 3

Classifications:



External Ids:

Disease Ontology 12 DOID:13035
ICD9CM 36 087.0
NCIt 51 C128426
SNOMED-CT 69 14683004
ICD10 34 A68.0
UMLS 74 C0152061

Summaries for Louse-Borne Relapsing Fever

Disease Ontology : 12 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted by body louse (Pediculus humanus). The infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Louse-Borne Relapsing Fever, also known as relapsing fever, louse-borne, is related to relapsing fever and pediculus humanus corporis infestation, and has symptoms including lymphadenopathy, tachycardia and tachypnea. An important gene associated with Louse-Borne Relapsing Fever is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Human cytomegalovirus infection. Affiliated tissues include heart, and related phenotype is Reduced mammosphere formation.

CDC : 3 LBRF is caused by a spiral-shaped bacteria, Borrelia recurrentis, which is transmitted from human to human by the body louse. LBRF outbreaks most commonly occur in conditions of overcrowding and social disruption.

Related Diseases for Louse-Borne Relapsing Fever

Diseases related to Louse-Borne Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 relapsing fever 32.9 ARSI CRP TNF
2 pediculus humanus corporis infestation 11.5
3 drug reaction with eosinophilia and systemic symptoms 10.4 CRP TNF
4 scorpion envenomation 10.4 IL6 TNF
5 salpingitis 10.4 CRP TNF
6 cold agglutinin disease 10.3 CRP IL6
7 immunodeficiency due to a classical component pathway complement deficiency 10.3 C4A C4B
8 leukomalacia 10.3 IL6 TNF
9 acquired angioedema 10.3 CRP SERPING1
10 leukorrhea 10.3 CRP NFKBIA
11 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
12 autoimmune myocarditis 10.3 IL6 TNF
13 exudative glomerulonephritis 10.3 CXCL8 TNF
14 juvenile dermatitis herpetiformis 10.3 C4A C4B
15 critical limb ischemia 10.3 IL6 TNF
16 cryopyrin-associated periodic syndrome 10.3 CRP IL6
17 juvenile ankylosing spondylitis 10.3 IL6 TNF
18 cardiogenic shock 10.3 IL6 TNF
19 acute cholangitis 10.3 CRP IL6
20 myasthenic syndrome, congenital, 1a, slow-channel 10.3 CRP CXCL8
21 null-cell leukemia 10.3 IL6 TNF
22 central nervous system vasculitis 10.3 CRP IL6 TNF
23 ischemic heart disease 10.2 CRP IL6 TNF
24 mycoplasma pneumoniae pneumonia 10.2 CRP IL6 TNF
25 apnea, obstructive sleep 10.2 CRP IL6 TNF
26 adult-onset still's disease 10.2 CRP IL6 TNF
27 exanthem 10.2 CRP IL6 TNF
28 infective endocarditis 10.2 CRP IL6 TNF
29 extrinsic cardiomyopathy 10.2 CRP IL6 TNF
30 lymph node disease 10.2 CRP IL6 TNF
31 indeterminate leprosy 10.2 C4A C4B TNF
32 pericarditis 10.2 CRP IL6 TNF
33 temporal arteritis 10.2 CRP IL6 TNF
34 retinitis pigmentosa 55 10.2 IL6 TNF
35 typhoid fever 10.2 CRP IL6 TNF
36 tungiasis 10.2 CXCL8 TNF
37 malaria 10.2
38 epidemic typhus 10.2
39 syphilis 10.2
40 pancreas disease 10.2 CRP IL6 TNF
41 takayasu arteritis 10.2 CRP IL6 TNF
42 end stage renal failure 10.2 CRP IL6 TNF
43 spondylitis 10.2 CRP IL6 TNF
44 juvenile rheumatoid arthritis 10.2 CRP IL6 TNF
45 cholangitis 10.2 CRP IL6 TNF
46 overnutrition 10.2 CRP IL6 TNF
47 arteries, anomalies of 10.2 CRP IL6 TNF
48 uremic pruritus 10.2 CRP IL6
49 glucose metabolism disease 10.2 CRP IL6 TNF
50 pyuria 10.2 CRP CXCL8

Graphical network of the top 20 diseases related to Louse-Borne Relapsing Fever:



Diseases related to Louse-Borne Relapsing Fever

Symptoms & Phenotypes for Louse-Borne Relapsing Fever

Symptoms:

12
  • lymphadenopathy
  • tachycardia
  • tachypnea
  • hepatosplenomegaly

GenomeRNAi Phenotypes related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 C4A CFHR1 CXCL8 GAB2 MAPK1 RAD51

Drugs & Therapeutics for Louse-Borne Relapsing Fever

Search Clinical Trials , NIH Clinical Center for Louse-Borne Relapsing Fever

Genetic Tests for Louse-Borne Relapsing Fever

Anatomical Context for Louse-Borne Relapsing Fever

MalaCards organs/tissues related to Louse-Borne Relapsing Fever:

42
Heart

Publications for Louse-Borne Relapsing Fever

Articles related to Louse-Borne Relapsing Fever:

(show top 50) (show all 72)
# Title Authors Year
1
Louse-borne relapsing fever (Borrelia recurrentis infection). ( 30869050 )
2019
2
Outbreak of Louse-Borne Relapsing Fever among Urban Dwellers in Arsi Zone, Central Ethiopia, from July to November 2016. ( 29692298 )
2018
3
Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa. ( 29016302 )
2017
4
Louse-borne relapsing fever in Finland in two asylum seekers from Somalia. ( 27859692 )
2017
5
Louse-borne relapsing fever in a refugee from Mali. ( 28161771 )
2017
6
Louse-Borne Relapsing Fever (Borrelia recurrentis) in a Somali Refugee Arriving in Italy: A Re-emerging Infection in Europe? ( 27149282 )
2016
7
Louse-borne relapsing fever among East African refugees in Europe. ( 26872415 )
2016
8
Fourth case of louse-borne relapsing fever in Young Migrant, Sicily, Italy, December 2015. Mini Review Article. ( 27340042 )
2016
9
Louse-borne relapsing fever - report of four cases in Switzerland, June-December 2015. ( 27188655 )
2016
10
Louse-borne relapsing fever in a refugee from Somalia arriving in Belgium. ( 27356309 )
2016
11
Louse-Borne Relapsing Fever with Meningeal Involvement in an Immigrant from Somalia to Italy, October 2015. ( 26938933 )
2016
12
Louse-borne relapsing fever (Borrelia recurrentis) in an Eritrean refugee arriving in Switzerland, August 2015. ( 26290486 )
2015
13
Louse-borne relapsing fever (Borrelia recurrentis) in asylum seekers from Eritrea, the Netherlands, July 2015. ( 26250069 )
2015
14
Louse-borne relapsing fever (Borrelia recurrentis) diagnosed in 15 refugees from northeast Africa: epidemiology and preventive control measures, Bavaria, Germany, July to October 2015. ( 26538532 )
2015
15
Prevalence and risk factors of louse-borne relapsing fever in high risk populations in Bahir Dar city Northwest, Ethiopia. ( 25196787 )
2014
16
Louse-borne relapsing fever profile at Felegehiwot referral hospital, Bahir Dar city, Ethiopia: a retrospective study. ( 24742342 )
2014
17
Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis. ( 21803390 )
2011
18
Louse-borne relapsing fever in Ethiopian children: experience of a rural hospital. ( 19211422 )
2009
19
A novel animal model of Borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice. ( 19787030 )
2009
20
Results of a 10-year survey of louse-borne relapsing fever in southern Ethiopia: a decline in endemicity. ( 18577339 )
2008
21
The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii. ( 18787695 )
2008
22
Louse-borne relapsing fever and malaria co-infection in Ethiopia. ( 17540107 )
2007
23
Characteristics of louse-borne relapsing fever in Ethiopian children and adults. ( 15035729 )
2004
24
Serodiagnosis of Louse-Borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis. ( 11015364 )
2000
25
Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever. ( 9846580 )
1998
26
The effect of antibody against TNF alpha on cytokine response in Jarisch-Herxheimer reactions of louse-borne relapsing fever. ( 9093599 )
1997
27
Outbreak of louse-borne relapsing fever in Jimma, south western Ethiopia. ( 8625865 )
1996
28
Tumour necrosis factor, interleukin-6 and C-reactive protein in patients with louse-borne relapsing fever in Ethiopia. ( 7741594 )
1995
29
Louse-borne relapsing fever in southern Sudan. ( 8594674 )
1995
30
Louse-borne relapsing fever and its treatment. ( 8592762 )
1995
31
Treatment of louse-borne relapsing fever with low dose penicillin or tetracycline: a clinical trial. ( 7784810 )
1995
32
Louse-borne relapsing fever. Giulio Borgnolo et al. Tropical and Geographical Medicine 1993;45(2):66-9. ( 7941015 )
1994
33
Louse-borne relapsing fever epidemic in Arssi Region, Ethiopia: a six months survey. ( 8337714 )
1993
34
Epidemic of louse-borne relapsing fever in Ethiopia. ( 7901534 )
1993
35
Louse-borne relapsing fever. A clinical and an epidemiological study of 389 patients in Asella Hospital, Ethiopia. ( 8511813 )
1993
36
Louse-borne relapsing fever in Ethiopian children: a clinical study. ( 7687113 )
1993
37
Louse-borne relapsing fever in children. ( 1597878 )
1992
38
Tetracycline versus penicillin in the treatment of louse-borne relapsing fever. ( 1396621 )
1992
39
Louse-borne relapsing fever in Ethiopia. ( 1681201 )
1991
40
Clinical presentation of louse-borne relapsing fever among Ethiopian refugees in northern Somalia. ( 3257078 )
1988
41
Louse borne relapsing fever (LBRF): mortality and frequency of Jarisch-Herxheimer reaction. ( 3116249 )
1987
42
Pathophysiology and immunology of the Jarisch-Herxheimer-like reaction in louse-borne relapsing fever: comparison of tetracycline and slow-release penicillin. ( 6842024 )
1983
43
Antibiotic treatment of louse-borne relapsing fever in Ethiopia: a report of 377 cases. ( 6625065 )
1983
44
Louse-borne relapsing fever in the Sudan. A historical review and a clinico-pathological study. ( 7423600 )
1980
45
Louse-borne relapsing fever: I. A clinical and laboratory study of 363 cases in the Sudan. ( 871032 )
1977
46
Louse-borne relapsing fever: II. Combined penicillin and tetracycline therapy in 160 Sudanese patients. ( 871033 )
1977
47
Bleeding in louse-borne relapsing fever in Ethiopia; clinical and laboratory features in 29 patients. ( 964178 )
1976
48
Louse-borne relapsing fever in man. ( 4811584 )
1974
49
Single-dose doxycycline treatment of louse-borne relapsing fever and epidemic typhus. ( 4143011 )
1974
50
Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. II. Pathology. ( 4217571 )
1974

Variations for Louse-Borne Relapsing Fever

Expression for Louse-Borne Relapsing Fever

Search GEO for disease gene expression data for Louse-Borne Relapsing Fever.

Pathways for Louse-Borne Relapsing Fever

Pathways related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 CXCL8 IL6 MAPK1 NFKBIA TNF
2
Show member pathways
12.9 CXCL8 IL6 MAPK1 NFKBIA TNF
3
Show member pathways
12.78 C4A CXCL8 IL6 MAPK1 NFKBIA TNF
4 12.77 CXCL8 IL6 MAPK1 NFKBIA RAD51
5
Show member pathways
12.57 GAB2 MAPK1 NFKBIA TNF
6
Show member pathways
12.54 IL6 MAPK1 NFKBIA TNF
7
Show member pathways
12.53 GAB2 MAPK1 NFKBIA TNF
8
Show member pathways
12.51 CXCL8 IL6 MAPK1 NFKBIA TNF
9
Show member pathways
12.51 IL6 MAPK1 NFKBIA RAD51 TNF
10
Show member pathways
12.32 GAB2 IL6 MAPK1 NFKBIA TNF
11
Show member pathways
12.21 CXCL8 IL6 MAPK1 NFKBIA TNF
12
Show member pathways
12.19 CXCL8 IL6 MAPK1 NFKBIA TNF
13
Show member pathways
12.14 IL6 MAPK1 NFKBIA TNF
14
Show member pathways
12.13 CXCL8 IL6 MAPK1 NFKBIA TNF
15
Show member pathways
12.11 CXCL8 IL6 NFKBIA TNF
16
Show member pathways
12.08 CXCL8 IL6 MAPK1 NFKBIA TNF
17 12.01 C4A C4B CXCL8 IL6 TNF
18
Show member pathways
12 C4A C4B CRP SERPING1
19 11.97 GAB2 MAPK1 NFKBIA TNF
20 11.96 GAB2 MAPK1 TNF
21 11.93 CXCL8 IL6 TNF
22 11.93 CXCL8 IL6 MAPK1 TNF
23
Show member pathways
11.91 GAB2 MAPK1 NFKBIA
24
Show member pathways
11.91 IL6 NFKBIA TNF
25 11.89 CXCL8 IL6 MAPK1
26
Show member pathways
11.89 C4A C4B SERPING1
27 11.88 IL6 MAPK1 NFKBIA TNF
28 11.84 CXCL8 IL6 TNF
29 11.83 CXCL8 NFKBIA TNF
30 11.83 CXCL8 IL6 MAPK1 TNF
31 11.82 CXCL8 MAPK1 NFKBIA
32
Show member pathways
11.82 CXCL8 IL6 NFKBIA
33 11.8 CXCL8 IL6 TNF
34 11.78 CXCL8 IL6 MAPK1
35
Show member pathways
11.75 CXCL8 MAPK1 NFKBIA
36 11.74 CXCL8 IL6 MAPK1
37 11.68 MAPK1 NFKBIA TNF
38 11.63 CXCL8 IL6 NFKBIA
39 11.63 CXCL8 MAPK1 NFKBIA
40 11.61 CXCL8 IL6 TNF
41 11.54 CXCL8 IL6 MAPK1
42 11.48 CXCL8 IL6 TNF
43 11.48 CXCL8 IL6 TNF
44 11.42 MAPK1 NFKBIA TNF
45 11.41 CXCL8 IL6 NFKBIA TNF
46
Show member pathways
11.35 CXCL8 IL6 MAPK1 NFKBIA TNF
47
Show member pathways
11.16 GAB2 MAPK1 NFKBIA
48 11.05 C4A C4B CXCL8 IL6 MAPK1 SERPING1
49 11.03 CXCL8 GAB2 IL6 MAPK1 NFKBIA
50 11 CXCL8 MAPK1 NFKBIA TNF

GO Terms for Louse-Borne Relapsing Fever

Cellular components related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 C4A C4B CFHR1 CRP CXCL8 DDT
2 blood microparticle GO:0072562 9.46 C4A C4B CFHR1 SERPING1
3 extracellular region GO:0005576 9.32 ARSI C4A C4B CFHR1 CRP CXCL8

Biological processes related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.78 CXCL8 GAB2 IL6 TNF
2 cellular response to tumor necrosis factor GO:0071356 9.73 CXCL8 MAPK1 NFKBIA
3 defense response to Gram-positive bacterium GO:0050830 9.69 CRP IL6 TNF
4 complement activation GO:0006956 9.67 C4A C4B CFHR1
5 positive regulation of inflammatory response GO:0050729 9.63 DDT NFKBIA TNF
6 complement activation, classical pathway GO:0006958 9.62 C4A C4B CRP SERPING1
7 positive regulation of chemokine production GO:0032722 9.57 IL6 TNF
8 embryonic digestive tract development GO:0048566 9.55 CXCL8 TNF
9 positive regulation of glial cell proliferation GO:0060252 9.54 IL6 TNF
10 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.52 CRP NFKBIA
11 regulation of complement activation GO:0030449 9.46 C4A C4B CFHR1 SERPING1
12 opsonization GO:0008228 9.43 C4B CRP
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 MAPK1 NFKBIA TNF
14 inflammatory response GO:0006954 9.43 C4A C4B CRP CXCL8 IL6 TNF
15 positive regulation of apoptotic cell clearance GO:2000427 9.4 C4A C4B
16 positive regulation of neuroinflammatory response GO:0150078 9.37 IL6 TNF
17 negative regulation of lipid storage GO:0010888 8.92 CRP IL6 NFKBIA TNF

Molecular functions related to Louse-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement component C1q binding GO:0001849 8.62 C4A CRP

Sources for Louse-Borne Relapsing Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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