MCID: LWC001
MIFTS: 32

Low Compliance Bladder

Categories: Nephrological diseases

Aliases & Classifications for Low Compliance Bladder

MalaCards integrated aliases for Low Compliance Bladder:

Name: Low Compliance Bladder 12 15 73
Hyperactivity of Bladder 12
Hypertonicity of Bladder 12
Low Bladder Compliance 12
Hypertonic Bladder 12
Overactive Bladder 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12144
ICD9CM 35 596.52
SNOMED-CT 68 9009001

Summaries for Low Compliance Bladder

MalaCards based summary : Low Compliance Bladder, also known as hyperactivity of bladder, is related to hydronephrosis and cystitis, and has symptoms including dysuria, prostatism and urgency of micturition. An important gene associated with Low Compliance Bladder is CHRM3 (Cholinergic Receptor Muscarinic 3), and among its related pathways/superpathways are Peptide ligand-binding receptors and Myometrial Relaxation and Contraction Pathways. Affiliated tissues include prostate and spinal cord, and related phenotypes are Increased cell number in S and growth/size/body region

Related Diseases for Low Compliance Bladder

Diseases related to Low Compliance Bladder via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hydronephrosis 9.8
2 cystitis 9.8
3 ureteral obstruction 9.8
4 neurogenic bladder 9.7 CHRM2 P2RX2

Comorbidity relations with Low Compliance Bladder via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Prostatic Hypertrophy

Symptoms & Phenotypes for Low Compliance Bladder

UMLS symptoms related to Low Compliance Bladder:


dysuria, prostatism, urgency of micturition, lower urinary tract symptoms

GenomeRNAi Phenotypes related to Low Compliance Bladder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell number in S GR00096-A 8.8 CHRM2 CHRM3 P2RX2

MGI Mouse Phenotypes related to Low Compliance Bladder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.55 ADRB3 CHRM2 CHRM3 MEOX2 RAB34
2 homeostasis/metabolism MP:0005376 9.43 ADRB3 CHRM2 CHRM3 MEOX2 P2RX2 RAB34
3 respiratory system MP:0005388 8.92 CHRM2 CHRM3 MEOX2 P2RX2

Drugs & Therapeutics for Low Compliance Bladder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction Recruiting NCT02859844 Not Applicable

Search NIH Clinical Center for Low Compliance Bladder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Low Compliance Bladder

Anatomical Context for Low Compliance Bladder

MalaCards organs/tissues related to Low Compliance Bladder:

41
Prostate, Spinal Cord

Publications for Low Compliance Bladder

Articles related to Low Compliance Bladder:

# Title Authors Year
1
Low compliance bladder. ( 27343340 )
2016
2
URB937, a peripherally restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibres in rats. ( 26189783 )
2016
3
Video-urodynamic effects of mirabegron, a I^3 -adrenoceptor agonist, in patients with low-compliance bladder. ( 26177781 )
2015
4
Low compliance bladder plays a role in hydronephrosis in lupus cystitis: a case report. ( 24596124 )
2014
5
Laparoscopic diverticulocystoplasty for low compliance bladder in a child. ( 23318084 )
2012
6
Efficacy of extended-release tolterodine for the treatment of neurogenic detrusor overactivity and/or low-compliance bladder. ( 20969642 )
2010
7
Botulinum toxin type A injections for treating neurogenic detrusor overactivity combined with low-compliance bladder in patients with spinal cord lesions. ( 16271557 )
2005
8
Significance of low compliance bladder in cauda equina injury. ( 12483499 )
2002
9
Initial clinical experience with the selective phosphodiesterase-I isoenzyme inhibitor vinpocetine in the treatment of urge incontinence and low compliance bladder. ( 11204266 )
2000
10
Gastrocystoplasty in a woman with radiation-induced ureteral obstruction and low-compliance bladder. ( 9792987 )
1998

Variations for Low Compliance Bladder

Expression for Low Compliance Bladder

Search GEO for disease gene expression data for Low Compliance Bladder.

Pathways for Low Compliance Bladder

GO Terms for Low Compliance Bladder

Cellular components related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.56 ADRB3 CHRM2 CHRM3 P2RX2
2 integral component of presynaptic membrane GO:0099056 9.16 CHRM2 CHRM3
3 axon terminus GO:0043679 8.96 CHRM2 CHRM3
4 asymmetric synapse GO:0032279 8.62 CHRM2 CHRM3

Biological processes related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.43 CHRM2 CHRM3 P2RX2
2 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.37 ADRB3 CHRM2
3 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.32 CHRM2 CHRM3
4 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.16 CHRM2 CHRM3
5 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway GO:0007197 8.96 CHRM2 CHRM3
6 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 8.8 ADRB3 CHRM2 CHRM3

Molecular functions related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.5 ADRB3 CHRM2 CHRM3
2 drug binding GO:0008144 9.26 CHRM2 CHRM3
3 neurotransmitter receptor activity GO:0030594 9.16 CHRM2 CHRM3
4 G protein-coupled serotonin receptor activity GO:0004993 8.96 CHRM2 CHRM3
5 G protein-coupled acetylcholine receptor activity GO:0016907 8.62 CHRM2 CHRM3

Sources for Low Compliance Bladder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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