MCID: LWC001
MIFTS: 29

Low Compliance Bladder

Categories: Nephrological diseases

Aliases & Classifications for Low Compliance Bladder

MalaCards integrated aliases for Low Compliance Bladder:

Name: Low Compliance Bladder 12 15 73
Hyperactivity of Bladder 12
Hypertonicity of Bladder 12
Low Bladder Compliance 12
Hypertonic Bladder 12
Overactive Bladder 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12144
ICD9CM 35 596.52
SNOMED-CT 68 9009001

Summaries for Low Compliance Bladder

MalaCards based summary : Low Compliance Bladder, also known as hyperactivity of bladder, is related to hydronephrosis and cystitis, and has symptoms including dysuria, urgency of micturition and prostatism. An important gene associated with Low Compliance Bladder is RAB34 (RAB34, Member RAS Oncogene Family), and among its related pathways/superpathways are Platelet homeostasis and Calcium signaling pathway. Affiliated tissues include prostate and spinal cord, and related phenotype is Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation.

Related Diseases for Low Compliance Bladder

Diseases related to Low Compliance Bladder via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hydronephrosis 9.7
2 cystitis 9.7
3 ureteral obstruction 9.7
4 neurogenic bladder 8.9 P2RX1 P2RX2

Comorbidity relations with Low Compliance Bladder via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Prostatic Hypertrophy

Symptoms & Phenotypes for Low Compliance Bladder

UMLS symptoms related to Low Compliance Bladder:


dysuria, urgency of micturition, prostatism, lower urinary tract symptoms

GenomeRNAi Phenotypes related to Low Compliance Bladder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation GR00203-A 8.62 P2RX1 P2RX2

Drugs & Therapeutics for Low Compliance Bladder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction Recruiting NCT02859844 Not Applicable

Search NIH Clinical Center for Low Compliance Bladder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Low Compliance Bladder

Anatomical Context for Low Compliance Bladder

MalaCards organs/tissues related to Low Compliance Bladder:

41
Prostate, Spinal Cord

Publications for Low Compliance Bladder

Articles related to Low Compliance Bladder:

# Title Authors Year
1
Low compliance bladder. ( 27343340 )
2016
2
Video-urodynamic effects of mirabegron, a I^3 -adrenoceptor agonist, in patients with low-compliance bladder. ( 26177781 )
2015
3
Low compliance bladder plays a role in hydronephrosis in lupus cystitis: a case report. ( 24596124 )
2014
4
Laparoscopic diverticulocystoplasty for low compliance bladder in a child. ( 23318084 )
2012
5
Efficacy of extended-release tolterodine for the treatment of neurogenic detrusor overactivity and/or low-compliance bladder. ( 20969642 )
2010
6
Botulinum toxin type A injections for treating neurogenic detrusor overactivity combined with low-compliance bladder in patients with spinal cord lesions. ( 16271557 )
2005
7
Significance of low compliance bladder in cauda equina injury. ( 12483499 )
2002
8
Initial clinical experience with the selective phosphodiesterase-I isoenzyme inhibitor vinpocetine in the treatment of urge incontinence and low compliance bladder. ( 11204266 )
2000
9
Gastrocystoplasty in a woman with radiation-induced ureteral obstruction and low-compliance bladder. ( 9792987 )
1998

Variations for Low Compliance Bladder

Expression for Low Compliance Bladder

Search GEO for disease gene expression data for Low Compliance Bladder.

Pathways for Low Compliance Bladder

Pathways related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.23 P2RX1 P2RX2
2
Show member pathways
10.89 P2RX1 P2RX2

GO Terms for Low Compliance Bladder

Cellular components related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynapse GO:0098794 8.96 P2RX1 P2RX2
2 integral component of nuclear inner membrane GO:0005639 8.62 P2RX1 P2RX2

Biological processes related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homooligomerization GO:0051260 9.43 P2RX1 P2RX2
2 blood coagulation GO:0007596 9.4 P2RX1 P2RX2
3 response to organic substance GO:0010033 9.37 P2RX1 P2RX2
4 cation transport GO:0006812 9.32 P2RX1 P2RX2
5 excitatory postsynaptic potential GO:0060079 9.26 P2RX1 P2RX2
6 cation transmembrane transport GO:0098655 9.16 P2RX1 P2RX2
7 response to ATP GO:0033198 8.96 P2RX1 P2RX2
8 purinergic nucleotide receptor signaling pathway GO:0035590 8.62 P2RX1 P2RX2

Molecular functions related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.26 P2RX1 P2RX2
2 extracellularly ATP-gated cation channel activity GO:0004931 9.16 P2RX1 P2RX2
3 ATP-gated ion channel activity GO:0035381 8.96 P2RX1 P2RX2
4 purinergic nucleotide receptor activity GO:0001614 8.62 P2RX1 P2RX2

Sources for Low Compliance Bladder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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