MCID: LWG005
MIFTS: 39

Low-Grade Astrocytoma

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Low-Grade Astrocytoma

MalaCards integrated aliases for Low-Grade Astrocytoma:

Name: Low-Grade Astrocytoma 59

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

UMLS via Orphanet 73 C1314694
Orphanet 59 ORPHA251592

Summaries for Low-Grade Astrocytoma

MalaCards based summary : Low-Grade Astrocytoma is related to grade iii astrocytoma and glioblastoma. An important gene associated with Low-Grade Astrocytoma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Procarbazine and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and endothelial, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Low-Grade Astrocytoma

Diseases related to Low-Grade Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 grade iii astrocytoma 31.4 TP53 CDKN2B CDKN2A
2 glioblastoma 31.0 TP53 IDH1 CDKN2B CDKN2A CDKN1B
3 cerebellar astrocytoma 31.0 TP53 IDH1
4 glioma 31.0 TP53 TNC IDH1 CDKN2A
5 oligodendroglioma 30.9 TP53 IDH1 CDKN2B CDKN2A
6 juvenile pilocytic astrocytoma 30.8 TP53 TNC CDKN2A
7 mixed glioma 30.7 TP53 IDH1
8 meningioma, familial 30.2 TP53 STAT6 CDKN2A
9 glioblastoma multiforme 30.2 TP53 IL13RA2 IL13 IDH1 CDKN2A
10 fibrillary astrocytoma 11.8
11 astrocytoma 11.0
12 intracranial chondrosarcoma 10.7 TP53 IDH1
13 bladder squamous cell carcinoma 10.6 TP53 CDKN2A
14 keratinizing squamous cell carcinoma 10.6 TP53 CDKN2A
15 spitz nevus 10.6 TP53 CDKN2A
16 optic nerve sheath meningioma 10.6 PTGDS CDKN2A
17 scrotal carcinoma 10.6 TP53 CDKN2B CDKN2A
18 tonsil cancer 10.5 TP53 CDKN2A CDKN1B
19 inverted papilloma 10.5 TP53 CDKN2A CDKN1B
20 retinal cancer 10.5 TP53 CDKN2A CDKN1B
21 bladder carcinoma in situ 10.5 TP53 CDKN2A
22 skin melanoma 10.5 TP53 CDKN2B CDKN2A
23 li-fraumeni syndrome 10.5 TP53 IDH1 CDKN2A
24 upper respiratory tract disease 10.5 TP53 IL13 CDKN2A
25 myoclonic epilepsy of infancy 10.5 SCN8A SCN1A
26 leukemia, acute lymphoblastic 3 10.5 TP53 CDKN2B CDKN2A
27 pilocytic astrocytoma 10.5
28 deafness, autosomal dominant 16 10.4 SCN3A SCN2A
29 tenosynovial giant cell tumor 10.4 CDKN2B CDKN2A
30 neurofibromatosis, type iv, of riccardi 10.4
31 glial tumor 10.4
32 cellular schwannoma 10.4 TP53 SOX2 CDKN2A
33 dedifferentiated liposarcoma 10.4 TP53 STAT6 CDKN2A
34 sclerosing liposarcoma 10.4 TP53 STAT6
35 papilloma 10.3 TP53 CDKN2B CDKN2A CDKN1B
36 cholangiocarcinoma 10.3 TP53 IDH1 CDKN2A CDKN1B
37 ependymoma 10.3
38 actinic keratosis 10.3 TP53 TNC CDKN2A
39 lymphoepithelioma-like thymic carcinoma 10.3 IDH1 CDKN2A
40 benign ependymoma 10.3
41 cerebrum cancer 10.3 TP53 SOX2 IDH1 CDKN2A
42 supratentorial cancer 10.3 TP53 SOX2 IDH1 CDKN2A
43 central nervous system cancer 10.3 TP53 SOX2 IDH1 CDKN2A
44 neonatal period electroclinical syndrome 10.2 SCN8A SCN2A SCN1A
45 ocular cancer 10.2 TP53 SOX2 CDKN2A CDKN1B
46 nervous system cancer 10.2 TP53 IDH1 CDKN2B CDKN2A CDKN1B
47 ataxia and polyneuropathy, adult-onset 10.2
48 hydrocephalus 10.2
49 malignant glioma 10.2
50 chromosomal triplication 10.2

Graphical network of the top 20 diseases related to Low-Grade Astrocytoma:



Diseases related to Low-Grade Astrocytoma

Symptoms & Phenotypes for Low-Grade Astrocytoma

MGI Mouse Phenotypes related to Low-Grade Astrocytoma:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 BCAN CDKN1B CDKN2A NOVA1 PTGDS SCN1A
2 homeostasis/metabolism MP:0005376 10.33 CDKN1B CDKN2A CDKN2B HSPB1 IDH1 IL13
3 growth/size/body region MP:0005378 10.32 CDKN1B CDKN2A HSPB1 IDH1 IL13 NOVA1
4 cellular MP:0005384 10.28 CDKN1B CDKN2A CDKN2B HSPB1 IL13 IL13RA2
5 mortality/aging MP:0010768 10.27 CDKN1B CDKN2A CDKN2B IDH1 IL13 IL13RA1
6 hematopoietic system MP:0005397 10.26 CDKN1B CDKN2A CDKN2B HSPB1 IDH1 IL13
7 immune system MP:0005387 10.21 CDKN1B CDKN2A CDKN2B HSPB1 IDH1 IL13
8 endocrine/exocrine gland MP:0005379 10.18 CDKN1B CDKN2A CDKN2B IL13 IL13RA1 PTGDS
9 nervous system MP:0003631 10.1 BCAN CDKN1B CDKN2A IL13 NCAN NOVA1
10 integument MP:0010771 10.01 CDKN1B CDKN2A CDKN2B IL13 PTGDS SOX2
11 hearing/vestibular/ear MP:0005377 9.97 CDKN1B IL13 SCN8A SOX2 TNC TP53
12 no phenotypic analysis MP:0003012 9.9 CDKN1B CDKN2A CDKN2B HSPB1 IL13 IL13RA1
13 neoplasm MP:0002006 9.87 CDKN1B CDKN2A CDKN2B PTGDS SOX2 STAT6
14 reproductive system MP:0005389 9.61 CDKN1B CDKN2A CDKN2B IL13 SCN1A SCN8A
15 respiratory system MP:0005388 9.4 CDKN1B CDKN2A IDH1 IL13 IL13RA1 IL13RA2

Drugs & Therapeutics for Low-Grade Astrocytoma

Drugs for Low-Grade Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procarbazine Approved, Investigational Phase 3 671-16-9 4915
2
Lomustine Approved, Investigational Phase 3 13010-47-4 3950
3
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
4
Thioguanine Approved Phase 3 154-42-7 2723601
5
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
6 Antineoplastic Agents, Phytogenic Phase 3
7 Alkylating Agents Phase 3
8 Tubulin Modulators Phase 3
9 Antimitotic Agents Phase 3
10 Antimetabolites Phase 3
11 Antimetabolites, Antineoplastic Phase 3
12 Antineoplastic Agents, Alkylating Phase 3
13
Trioxsalen Approved Phase 2 3902-71-4 5585
14
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
15 Imatinib Mesylate Phase 2 220127-57-1 123596
16 Protein Kinase Inhibitors Phase 2
17 Dihematoporphyrin Ether Phase 2
18 Hematoporphyrin Derivative Phase 2
19 Hematoporphyrins Phase 2
20 Dermatologic Agents Phase 2
21 Ether Phase 2
22 Photosensitizing Agents Phase 2
23 Pharmaceutical Solutions Phase 2
24 Grapefruit Seed Extract Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than Ten Years Old Completed NCT00002944 Phase 3 carboplatin;lomustine;procarbazine hydrochloride;thioguanine;vincristine sulfate
2 Pediatric Low Grade Astrocytoma: Treatment Guidance Unknown status NCT00005084 Phase 2
3 Phase II Study of Antineoplastons A10 and AS2-1 in Children With Low Grade Astrocytoma Completed NCT00003468 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
4 Open Label Phase II Study On STI571 (Glivec) Administered As A Daily Oral Treatment In Gliomas Completed NCT00039364 Phase 2 imatinib mesylate
5 Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients With Low Grade Astrocytoma Terminated NCT00003471 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
6 A Phase II Study of Photodynamic Therapy (PDT) With Photofrin® (IND 104,613) For Recurrent High Grade Gliomas in Adults Terminated NCT01966809 Phase 2 Photofrin photodynamic therapy.
7 Phase II Study of Sorafenib in Children and Young Adults With Recurrent or Progressive Low-Grade Astrocytomas Terminated NCT01338857 Phase 2 Sorafenib (Nexavar)
8 Photodynamic Therapy (PDT) for Poor Prognosis Recurrent/Refractory Malignant Brain Tumors - A Phase I Study Completed NCT01682746 Phase 1 Photofrin (porfimer sodium) & photodynamic therapy.

Search NIH Clinical Center for Low-Grade Astrocytoma

Genetic Tests for Low-Grade Astrocytoma

Anatomical Context for Low-Grade Astrocytoma

MalaCards organs/tissues related to Low-Grade Astrocytoma:

41
Brain, Spinal Cord, Endothelial, Pineal, Temporal Lobe, Cortex, Bone

Publications for Low-Grade Astrocytoma

Articles related to Low-Grade Astrocytoma:

(show top 50) (show all 605)
# Title Authors PMID Year
1
Metabolic remodeling contributes towards an immune-suppressive phenotype in glioblastoma. 38
31119318 2019
2
Rescue bevacizumab following symptomatic pseudoprogression of a tectal glioma post-radiotherapy: a case report and review of the literature. 38
31054097 2019
3
Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy. 38
30624746 2019
4
BCR-NTRK2 fusion in a low-grade glioma with distinctive morphology and unexpected aggressive behavior. 38
30936198 2019
5
Neuroglial Differentiation and Neoplasms in Testicular Germ Cell Tumors Lack Immunohistochemical Evidence of Alterations Characteristic of Their CNS Counterparts: A Study of 13 Cases. 38
30557172 2019
6
Clinical characteristics, long-term complications and health-related quality of life (HRQoL) in children and young adults treated for low-grade astrocytoma in the posterior fossa in childhood. 38
30623287 2019
7
Integrative cross-platform analyses identify enhanced heterotrophy as a metabolic hallmark in glioblastoma. 38
30476237 2019
8
Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children. 38
30660880 2019
9
Seizure characteristics are related to tumor pathology in children with brain tumors. 38
30176531 2018
10
Immunohistochemical Evaluation of Hemostatic Changes in Glioblastoma Multiforme and Low-Grade Astrocytoma. 38
30649824 2018
11
Diagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors. 38
29238007 2018
12
Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study. 38
29687214 2018
13
Low-Grade Astrocytoma within a Mature Cystic Teratoma in an Adolescent Patient. 38
29107097 2018
14
Profound hearing loss following surgery in pediatric patients with posterior fossa low-grade glioma. 38
29770223 2018
15
Subventricular zone predicts high velocity of tumor expansion and poor clinical outcome in patients with low grade astrocytoma. 38
29500965 2018
16
Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma. 38
29578003 2018
17
Differentiation of High-Grade from Low-Grade Astrocytoma: Improvement in Diagnostic Accuracy and Reliability of Pharmacokinetic Parameters from DCE MR Imaging by Using Arterial Input Functions Obtained from DSC MR Imaging. 38
29244617 2018
18
A low-grade astrocytoma in a sixteen-year-old boy with a 7q11.22 deletion. 38
29445462 2018
19
Tumor Grade versus Expression of Invasion-Related Molecules in Astrocytoma. 38
28161812 2018
20
Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients. 38
30584325 2018
21
Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging. 38
30026674 2018
22
Presentation and symptom interval in children with central nervous system tumors. A single-center experience. 38
28808765 2017
23
Differentially Expressed Long Non-Coding RNAs Were Predicted to Be Involved in the Control of Signaling Pathways in Pediatric Astrocytoma. 38
27738870 2017
24
Novel strategies of Raman imaging for brain tumor research. 38
29156720 2017
25
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2. 38
29091765 2017
26
Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature. 38
28881745 2017
27
Low grade astrocytoma causing dural and calvarial destruction. 38
28242129 2017
28
The visuospatial functions in children after cerebellar low-grade astrocytoma surgery: A contribution to the pediatric neuropsychology of the cerebellum. 38
26638981 2017
29
Gene Expression Profiling of Chemokines and Their Receptors in Low and High Grade Astrocytoma 38
28610419 2017
30
Endoscopic Treatment of an Adult with Tegmental Astrocytoma Accompanied by Cerebrospinal Fluid Dissemination. 38
28490167 2017
31
Label-free quantitative proteomics unravels the importance of RNA processing in glioma malignancy. 38
28341197 2017
32
Segmentum: a tool for copy number analysis of cancer genomes. 38
28407731 2017
33
Concurrent TERT promoter and BRAF V600E mutation in epithelioid glioblastoma and concomitant low-grade astrocytoma. 38
27302309 2017
34
Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. 38
27770278 2017
35
Endoscopic Reconstruction of CSF Pathways in Ventricular Tumors. 38
28120058 2017
36
IDH1 R132H Mutation Is Accompanied with Malignant Progression of Paired Primary-Recurrent Astrocytic Tumours. 38
28928859 2017
37
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. 38
26984877 2016
38
Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery. 38
27741220 2016
39
Perinatal (fetal and neonatal) astrocytoma: a review. 38
27568373 2016
40
miRNA regulation of Sirtuin-1 expression in human astrocytoma. 38
27698888 2016
41
Rapid malignant transformation of low-grade astrocytoma in a pregnant woman. 38
27356501 2016
42
Clinical characteristics and late effects in CNS tumours of childhood: Do not forget long term follow-up of the low grade tumours. 38
27157245 2016
43
Imaging of Brain Tumors with Copper-64 Chloride: Early Experience and Results. 38
27228278 2016
44
A case of an epithelioid glioblastoma with the BRAF V600E mutation colocalized with BRAF intact low-grade diffuse astrocytoma. 38
26375727 2016
45
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults. 38
26848927 2016
46
Effects of Insula Resection on Autonomic Nervous System Activity. 38
26192246 2016
47
Congenital glioneuronal tumor with neuropil-like islands. 38
26455542 2016
48
Simultaneous 11C-Methionine Positron Emission Tomography/Magnetic Resonance Imaging of Suspected Primary Brain Tumors. 38
27907162 2016
49
Prognostic Value of ALDH1, EZH2 and Ki-67 in Astrocytic Gliomas. 38
27136105 2016
50
Manganese superoxide dismutase (MnSOD) is a malignant astrocytoma specific biomarker and associated with adverse prognosis in p53 expressing glioblastoma. 38
26616112 2016

Variations for Low-Grade Astrocytoma

Copy number variations for Low-Grade Astrocytoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 109389 17 25800000 31800000 Copy number NF1 Low-grade astrocytoma
2 220389 7 138060226 140654186 Copy number HIPK2 Low-grade astrocytoma
3 220401 7 138200000 143100000 Copy number BRAF Low-grade astrocytoma
4 220626 7 140080752 140271033 Copy number Low-grade astrocytoma

Expression for Low-Grade Astrocytoma

Search GEO for disease gene expression data for Low-Grade Astrocytoma.

Pathways for Low-Grade Astrocytoma

Pathways related to Low-Grade Astrocytoma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 TP53 TNC STAT6 SOX2 NCAN IL13RA2
2
Show member pathways
13.27 TP53 STAT6 IL13RA2 IL13RA1 IL13 HSPB1
3 12.52 TP53 STAT6 IL13RA1 IL13 CDKN2B CDKN2A
4 12.39 TP53 TNC CDKN2A CDKN1B
5
Show member pathways
12.25 STAT6 IL13RA2 IL13RA1 IL13
6 12.22 TP53 CDKN2B CDKN2A CDKN1B
7
Show member pathways
12.2 TP53 CDKN2B CDKN2A CDKN1B
8 12.14 TP53 CDKN2B CDKN2A CDKN1B
9 11.85 TP53 CDKN2A CDKN1B
10 11.83 TP53 CDKN2A CDKN1B
11
Show member pathways
11.83 TNC NCAN IL13 BCAN
12 11.79 TP53 CDKN2A CDKN1B
13 11.75 TP53 NCAN CDKN1B BCAN
14 11.71 TP53 CDKN2B CDKN1B
15
Show member pathways
11.65 SCN8A SCN3A SCN2A SCN1A NCAN
16 11.5 STAT6 IL13RA2 IL13RA1
17
Show member pathways
11.5 SCN8A SCN3A SCN2A SCN1A
18 11.44 TNC NCAN BCAN
19 11.33 TP53 CDKN2B CDKN1B
20 11.24 TNC NCAN BCAN
21 11.16 TP53 STAT6 SOX2 IL13RA2 IL13RA1 IL13
22 11.09 TP53 CDKN2B CDKN2A
23 10.73 SCN8A SCN3A SCN2A SCN1A

GO Terms for Low-Grade Astrocytoma

Cellular components related to Low-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium channel complex GO:0034706 9.16 SCN2A SCN1A
2 node of Ranvier GO:0033268 9.13 SCN8A SCN2A SCN1A
3 voltage-gated sodium channel complex GO:0001518 8.92 SCN8A SCN3A SCN2A SCN1A

Biological processes related to Low-Grade Astrocytoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.83 SCN8A SCN3A SCN2A SCN1A
2 regulation of ion transmembrane transport GO:0034765 9.73 SCN8A SCN3A SCN2A SCN1A
3 cytokine-mediated signaling pathway GO:0019221 9.73 TP53 STAT6 SOX2 IL13RA2 IL13RA1 IL13
4 sodium ion transport GO:0006814 9.71 SCN8A SCN3A SCN2A SCN1A
5 negative regulation of epithelial cell proliferation GO:0050680 9.63 SOX2 CDKN2B CDKN1B
6 sodium ion transmembrane transport GO:0035725 9.62 SCN8A SCN3A SCN2A SCN1A
7 cell cycle arrest GO:0007050 9.55 TP53 SOX2 CDKN2B CDKN2A CDKN1B
8 negative regulation of phosphorylation GO:0042326 9.54 CDKN2B CDKN2A CDKN1B
9 chondroitin sulfate catabolic process GO:0030207 9.51 NCAN BCAN
10 replicative senescence GO:0090399 9.49 TP53 CDKN2A
11 dermatan sulfate biosynthetic process GO:0030208 9.48 NCAN BCAN
12 neuronal action potential GO:0019228 9.26 SCN8A SCN3A SCN2A SCN1A
13 membrane depolarization during action potential GO:0086010 8.92 SCN8A SCN3A SCN2A SCN1A

Molecular functions related to Low-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.77 TP53 HSPB1 CDKN2B CDKN2A CDKN1B
2 ion channel activity GO:0005216 9.62 SCN8A SCN3A SCN2A SCN1A
3 protein phosphatase binding GO:0019903 9.58 TP53 STAT6 CDKN1B
4 voltage-gated ion channel activity GO:0005244 9.56 SCN8A SCN3A SCN2A SCN1A
5 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.33 CDKN2B CDKN2A CDKN1B
6 sodium channel activity GO:0005272 9.26 SCN8A SCN3A SCN2A SCN1A
7 voltage-gated sodium channel activity GO:0005248 8.92 SCN8A SCN3A SCN2A SCN1A

Sources for Low-Grade Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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