MCID: LWG005
MIFTS: 38

Low-Grade Astrocytoma

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Low-Grade Astrocytoma

MalaCards integrated aliases for Low-Grade Astrocytoma:

Name: Low-Grade Astrocytoma 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

UMLS via Orphanet 72 C1314694
Orphanet 58 ORPHA251592

Summaries for Low-Grade Astrocytoma

MalaCards based summary : Low-Grade Astrocytoma is related to fibrillary astrocytoma and grade iii astrocytoma. An important gene associated with Low-Grade Astrocytoma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Procarbazine and Thioguanine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Low-Grade Astrocytoma

Diseases related to Low-Grade Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 33.4 TP53 IDH1 CDKN2A
2 grade iii astrocytoma 31.0 TP53 IDH1 CDKN2B CDKN2A
3 glioma 30.7 TP53 TNC IDH1 CDKN2A
4 glioma susceptibility 1 30.3 TP53 TNC IDH1 CDKN2A
5 melanoma, cutaneous malignant 1 30.2 TP53 CDKN2B CDKN2A CDKN1B
6 oligodendroglioma 30.1 TP53 NOVA1 IDH1 HSPB1 CDKN2B CDKN2A
7 glioblastoma multiforme 29.6 TP53 SOX2 IL13RA2 IL13 IDH1 CDKN2B
8 meningioma, familial 29.4 TP53 STAT6 IDH1 CDKN2B CDKN2A
9 astrocytoma 11.0
10 vulvar intraepithelial neoplasia 10.5 TP53 CDKN2A
11 ovarian seromucinous carcinoma 10.5 TP53 CDKN2A
12 esophagus verrucous carcinoma 10.5 TP53 CDKN2A
13 spitz nevus 10.5 TP53 CDKN2A
14 frontal lobe neoplasm 10.5 TP53 IDH1
15 breast implant-associated anaplastic large cell lymphoma 10.5 TP53 IL13
16 breast hemangioma 10.5 TP53 IDH1
17 maxillary sinus adenocarcinoma 10.5 TP53 CDKN1B
18 juvenile pilocytic astrocytoma 10.5
19 suppressor of tumorigenicity 3 10.5 TP53 CDKN2A
20 adult astrocytic tumour 10.4 TP53 IDH1 CDKN2A
21 neurofibromatosis, type iv, of riccardi 10.4
22 supratentorial cancer 10.4 TP53 IDH1 CDKN2A
23 gliomatosis cerebri 10.4 TP53 IDH1 CDKN2A
24 chronic cervicitis 10.4 TP53 CDKN2A
25 thyroid lymphoma 10.4 TP53 CDKN2B CDKN2A
26 inverted papilloma 10.4 TP53 CDKN2A CDKN1B
27 endocervical adenocarcinoma 10.4 TP53 CDKN2A CDKN1B
28 spinal cord oligodendroglioma 10.4 TP53 IDH1
29 oral leukoplakia 10.4 TP53 CDKN2A
30 tonsil cancer 10.4 TP53 CDKN2A CDKN1B
31 giant cell glioblastoma 10.4 TP53 IDH1 CDKN2A
32 leukemia, acute lymphoblastic 3 10.4 TP53 CDKN2B CDKN2A
33 actinic keratosis 10.4 TP53 CDKN2B CDKN2A
34 childhood leukemia 10.3 TP53 CDKN2B CDKN2A
35 brain stem glioma 10.3 TP53 IL13RA2 IDH1
36 esophagitis 10.3 TP53 IL13 CDKN2A
37 gemistocytic astrocytoma 10.3 TP53 IDH1
38 benign ependymoma 10.3
39 glial tumor 10.3
40 primary cutaneous b-cell lymphoma 10.3 CDKN2B CDKN2A
41 gliofibroma 10.3 TP53 IDH1
42 chordoma 10.3 TP53 IDH1 CDKN2A
43 skin melanoma 10.3 TP53 CDKN2B CDKN2A
44 cellular ependymoma 10.3
45 genetic epilepsy with febrile seizures plus 10.2 SCN2A SCN1A
46 nervous system cancer 10.2 TP53 IDH1 CDKN2B CDKN2A
47 retinal cancer 10.2 TP53 CDKN2B CDKN2A CDKN1B
48 laryngeal squamous cell carcinoma 10.2 TP53 CDKN2B CDKN2A
49 mucoepidermoid carcinoma 10.2 TP53 CDKN2A CDKN1B
50 papilloma 10.2 TP53 CDKN2B CDKN2A CDKN1B

Graphical network of the top 20 diseases related to Low-Grade Astrocytoma:



Diseases related to Low-Grade Astrocytoma

Symptoms & Phenotypes for Low-Grade Astrocytoma

GenomeRNAi Phenotypes related to Low-Grade Astrocytoma according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.72 TP53
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.72 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.72 IDH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.72 IL13
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.72 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.72 IDH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.72 IDH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.72 IDH1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.72 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.72 STAT6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.72 STAT6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.72 TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.72 TP53
14 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.72 IL13
15 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.72 STAT6
16 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.72 TP53
17 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.72 IDH1 IL13 STAT6 TP53
18 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.72 STAT6
19 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.72 IDH1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.72 STAT6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.72 IL13
22 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.72 STAT6

MGI Mouse Phenotypes related to Low-Grade Astrocytoma:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.35 BCAN CDKN1B CDKN2A NOVA1 PTGDS SCN1A
2 growth/size/body region MP:0005378 10.31 CDKN1B CDKN2A HSPB1 IDH1 IL13 NOVA1
3 homeostasis/metabolism MP:0005376 10.31 CDKN1B CDKN2A CDKN2B HSPB1 IDH1 IL13
4 mortality/aging MP:0010768 10.27 CDKN1B CDKN2A CDKN2B IDH1 IL13 IL13RA1
5 cellular MP:0005384 10.26 CDKN1B CDKN2A CDKN2B HSPB1 IL13 IL13RA2
6 hematopoietic system MP:0005397 10.23 CDKN1B CDKN2A CDKN2B HSPB1 IDH1 IL13
7 immune system MP:0005387 10.18 CDKN1B CDKN2A CDKN2B HSPB1 IDH1 IL13
8 endocrine/exocrine gland MP:0005379 10.16 CDKN1B CDKN2A CDKN2B IL13 IL13RA1 PTGDS
9 nervous system MP:0003631 10.1 BCAN CDKN1B CDKN2A IL13 NCAN NOVA1
10 hearing/vestibular/ear MP:0005377 9.95 CDKN1B IL13 SCN8A SOX2 TNC TP53
11 no phenotypic analysis MP:0003012 9.9 CDKN1B CDKN2A CDKN2B HSPB1 IL13 IL13RA1
12 neoplasm MP:0002006 9.87 CDKN1B CDKN2A CDKN2B PTGDS SOX2 STAT6
13 reproductive system MP:0005389 9.61 CDKN1B CDKN2A CDKN2B IL13 SCN1A SCN8A
14 respiratory system MP:0005388 9.4 CDKN1B CDKN2A IDH1 IL13 IL13RA1 IL13RA2

Drugs & Therapeutics for Low-Grade Astrocytoma

Drugs for Low-Grade Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procarbazine Approved, Investigational Phase 3 671-16-9 4915
2
Thioguanine Approved Phase 3 154-42-7 2723601
3
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
4
Lomustine Approved, Investigational Phase 3 13010-47-4 3950
5
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
6 Alkylating Agents Phase 3
7 Antimitotic Agents Phase 3
8 Antimetabolites Phase 3
9
Trioxsalen Approved Phase 2 3902-71-4 5585
10
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
11 Imatinib Mesylate Phase 2 220127-57-1 123596
12 Protein Kinase Inhibitors Phase 2
13 Ether Phase 2
14 Hematoporphyrin Derivative Phase 2
15 Hematoporphyrins Phase 2
16 Dermatologic Agents Phase 2
17 Photosensitizing Agents Phase 2
18 Dihematoporphyrin Ether Phase 2
19 Pharmaceutical Solutions Phase 2
20 Grapefruit Seed Extract Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than Ten Years Old Completed NCT00002944 Phase 3 carboplatin;lomustine;procarbazine hydrochloride;thioguanine;vincristine sulfate
2 Pediatric Low Grade Astrocytoma: Treatment Guidance Unknown status NCT00005084 Phase 2
3 Phase II Study of Antineoplastons A10 and AS2-1 in Children With Low Grade Astrocytoma Completed NCT00003468 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
4 Open Label Phase II Study On STI571 (Glivec) Administered As A Daily Oral Treatment In Gliomas Completed NCT00039364 Phase 2 imatinib mesylate
5 Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients With Low Grade Astrocytoma Terminated NCT00003471 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
6 A Phase II Study of Photodynamic Therapy (PDT) With Photofrin® (IND 104,613) For Recurrent High Grade Gliomas in Adults Terminated NCT01966809 Phase 2 Photofrin photodynamic therapy.
7 Phase II Study of Sorafenib in Children and Young Adults With Recurrent or Progressive Low-Grade Astrocytomas Terminated NCT01338857 Phase 2 Sorafenib (Nexavar)
8 Photodynamic Therapy (PDT) for Poor Prognosis Recurrent/Refractory Malignant Brain Tumors - A Phase I Study Completed NCT01682746 Phase 1 Photofrin (porfimer sodium) & photodynamic therapy.

Search NIH Clinical Center for Low-Grade Astrocytoma

Genetic Tests for Low-Grade Astrocytoma

Anatomical Context for Low-Grade Astrocytoma

MalaCards organs/tissues related to Low-Grade Astrocytoma:

40
Brain, Spinal Cord, Thyroid, Endothelial, Pineal, Breast, B Cells

Publications for Low-Grade Astrocytoma

Articles related to Low-Grade Astrocytoma:

(show top 50) (show all 609)
# Title Authors PMID Year
1
Profiling of novel circulating microRNAs as a non-invasive biomarker in diagnosis and follow-up of high and low-grade gliomas. 61
31896490 2019
2
Low-grade astrocytoma in the setting of a developmental venous anomaly. 61
31776715 2019
3
Secondary INI1-deficient rhabdoid tumors of the central nervous system: analysis of four cases and literature review. 61
31707588 2019
4
Rescue bevacizumab following symptomatic pseudoprogression of a tectal glioma post-radiotherapy: a case report and review of the literature. 61
31054097 2019
5
Metabolic remodeling contributes towards an immune-suppressive phenotype in glioblastoma. 61
31119318 2019
6
Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy. 61
30624746 2019
7
BCR-NTRK2 fusion in a low-grade glioma with distinctive morphology and unexpected aggressive behavior. 61
30936198 2019
8
Neuroglial Differentiation and Neoplasms in Testicular Germ Cell Tumors Lack Immunohistochemical Evidence of Alterations Characteristic of Their CNS Counterparts: A Study of 13 Cases. 61
30557172 2019
9
Clinical characteristics, long-term complications and health-related quality of life (HRQoL) in children and young adults treated for low-grade astrocytoma in the posterior fossa in childhood. 61
30623287 2019
10
Integrative cross-platform analyses identify enhanced heterotrophy as a metabolic hallmark in glioblastoma. 61
30476237 2019
11
Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children. 61
30660880 2019
12
Are low-grade gliomas of mesial temporal area alone? 61
31583167 2019
13
Seizure characteristics are related to tumor pathology in children with brain tumors. 61
30176531 2018
14
Immunohistochemical Evaluation of Hemostatic Changes in Glioblastoma Multiforme and Low-Grade Astrocytoma. 61
30649824 2018
15
Diagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors. 61
29238007 2018
16
Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study. 61
29687214 2018
17
Low-Grade Astrocytoma within a Mature Cystic Teratoma in an Adolescent Patient. 61
29107097 2018
18
Profound hearing loss following surgery in pediatric patients with posterior fossa low-grade glioma. 61
29770223 2018
19
Subventricular zone predicts high velocity of tumor expansion and poor clinical outcome in patients with low grade astrocytoma. 61
29500965 2018
20
Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma. 61
29578003 2018
21
Differentiation of High-Grade from Low-Grade Astrocytoma: Improvement in Diagnostic Accuracy and Reliability of Pharmacokinetic Parameters from DCE MR Imaging by Using Arterial Input Functions Obtained from DSC MR Imaging. 61
29244617 2018
22
A low-grade astrocytoma in a sixteen-year-old boy with a 7q11.22 deletion. 61
29445462 2018
23
Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients. 61
30584325 2018
24
Tumor Grade versus Expression of Invasion-Related Molecules in Astrocytoma. 61
28161812 2018
25
Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging. 61
30026674 2018
26
Presentation and symptom interval in children with central nervous system tumors. A single-center experience. 61
28808765 2017
27
Differentially Expressed Long Non-Coding RNAs Were Predicted to Be Involved in the Control of Signaling Pathways in Pediatric Astrocytoma. 61
27738870 2017
28
Novel strategies of Raman imaging for brain tumor research. 61
29156720 2017
29
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2. 61
29091765 2017
30
Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature. 61
28881745 2017
31
Low grade astrocytoma causing dural and calvarial destruction. 61
28242129 2017
32
The visuospatial functions in children after cerebellar low-grade astrocytoma surgery: A contribution to the pediatric neuropsychology of the cerebellum. 61
26638981 2017
33
Gene Expression Profiling of Chemokines and Their Receptors in Low and High Grade Astrocytoma 61
28610419 2017
34
Endoscopic Treatment of an Adult with Tegmental Astrocytoma Accompanied by Cerebrospinal Fluid Dissemination. 61
28490167 2017
35
Label-free quantitative proteomics unravels the importance of RNA processing in glioma malignancy. 61
28341197 2017
36
Segmentum: a tool for copy number analysis of cancer genomes. 61
28407731 2017
37
Concurrent TERT promoter and BRAF V600E mutation in epithelioid glioblastoma and concomitant low-grade astrocytoma. 61
27302309 2017
38
Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. 61
27770278 2017
39
Endoscopic Reconstruction of CSF Pathways in Ventricular Tumors. 61
28120058 2017
40
IDH1 R132H Mutation Is Accompanied with Malignant Progression of Paired Primary-Recurrent Astrocytic Tumours. 61
28928859 2017
41
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. 61
26984877 2016
42
Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery. 61
27741220 2016
43
Perinatal (fetal and neonatal) astrocytoma: a review. 61
27568373 2016
44
miRNA regulation of Sirtuin-1 expression in human astrocytoma. 61
27698888 2016
45
Rapid malignant transformation of low-grade astrocytoma in a pregnant woman. 61
27356501 2016
46
Clinical characteristics and late effects in CNS tumours of childhood: Do not forget long term follow-up of the low grade tumours. 61
27157245 2016
47
Imaging of Brain Tumors with Copper-64 Chloride: Early Experience and Results. 61
27228278 2016
48
A case of an epithelioid glioblastoma with the BRAF V600E mutation colocalized with BRAF intact low-grade diffuse astrocytoma. 61
26375727 2016
49
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults. 61
26848927 2016
50
Effects of Insula Resection on Autonomic Nervous System Activity. 61
26192246 2016

Variations for Low-Grade Astrocytoma

Copy number variations for Low-Grade Astrocytoma from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 109389 17 25800000 31800000 Copy number NF1 Low-grade astrocytoma
2 220389 7 138060226 140654186 Copy number HIPK2 Low-grade astrocytoma
3 220401 7 138200000 143100000 Copy number BRAF Low-grade astrocytoma
4 220626 7 140080752 140271033 Copy number Low-grade astrocytoma

Expression for Low-Grade Astrocytoma

Search GEO for disease gene expression data for Low-Grade Astrocytoma.

Pathways for Low-Grade Astrocytoma

Pathways related to Low-Grade Astrocytoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 TP53 TNC STAT6 SOX2 NCAN IL13RA2
2
Show member pathways
13.28 TP53 STAT6 IL13RA2 IL13RA1 IL13 HSPB1
3 12.53 TP53 STAT6 IL13RA1 IL13 CDKN2B CDKN2A
4 12.23 TP53 CDKN2B CDKN2A CDKN1B
5
Show member pathways
12.21 TP53 CDKN2B CDKN2A CDKN1B
6
Show member pathways
12.18 STAT6 IL13RA2 IL13RA1 IL13
7 12.15 TP53 CDKN2B CDKN2A CDKN1B
8
Show member pathways
11.86 TNC NCAN IL13 BCAN
9 11.81 TP53 NCAN CDKN1B BCAN
10 11.72 TP53 CDKN2B CDKN1B
11
Show member pathways
11.65 SCN8A SCN3A SCN2A SCN1A NCAN
12 11.51 STAT6 IL13RA2 IL13RA1
13
Show member pathways
11.5 SCN8A SCN3A SCN2A SCN1A
14 11.46 TNC NCAN BCAN
15 11.33 TP53 CDKN2B CDKN1B
16 11.24 TNC NCAN BCAN
17 11.16 TP53 STAT6 SOX2 IL13RA2 IL13RA1 IL13
18 11.09 TP53 CDKN2B CDKN2A
19 10.73 SCN8A SCN3A SCN2A SCN1A

GO Terms for Low-Grade Astrocytoma

Cellular components related to Low-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium channel complex GO:0034706 9.16 SCN2A SCN1A
2 node of Ranvier GO:0033268 9.13 SCN8A SCN2A SCN1A
3 voltage-gated sodium channel complex GO:0001518 8.92 SCN8A SCN3A SCN2A SCN1A

Biological processes related to Low-Grade Astrocytoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.85 SCN8A SCN3A SCN2A SCN1A
2 regulation of cell proliferation GO:0042127 9.78 TP53 TNC STAT6 CDKN1B
3 regulation of ion transmembrane transport GO:0034765 9.76 SCN8A SCN3A SCN2A SCN1A
4 sodium ion transport GO:0006814 9.73 SCN8A SCN3A SCN2A SCN1A
5 cytokine-mediated signaling pathway GO:0019221 9.73 TP53 STAT6 SOX2 IL13RA2 IL13RA1 IL13
6 negative regulation of epithelial cell proliferation GO:0050680 9.67 SOX2 CDKN2B CDKN1B
7 sodium ion transmembrane transport GO:0035725 9.67 SCN8A SCN3A SCN2A SCN1A
8 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.58 CDKN2B CDKN2A CDKN1B
9 cell cycle arrest GO:0007050 9.55 TP53 SOX2 CDKN2B CDKN2A CDKN1B
10 chondroitin sulfate catabolic process GO:0030207 9.54 NCAN BCAN
11 replicative senescence GO:0090399 9.52 TP53 CDKN2A
12 dermatan sulfate biosynthetic process GO:0030208 9.51 NCAN BCAN
13 negative regulation of phosphorylation GO:0042326 9.5 CDKN2B CDKN2A CDKN1B
14 neuronal action potential GO:0019228 9.26 SCN8A SCN3A SCN2A SCN1A
15 membrane depolarization during action potential GO:0086010 8.92 SCN8A SCN3A SCN2A SCN1A

Molecular functions related to Low-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.77 TP53 HSPB1 CDKN2B CDKN2A CDKN1B
2 ion channel activity GO:0005216 9.62 SCN8A SCN3A SCN2A SCN1A
3 protein phosphatase binding GO:0019903 9.58 TP53 STAT6 CDKN1B
4 voltage-gated ion channel activity GO:0005244 9.56 SCN8A SCN3A SCN2A SCN1A
5 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.33 CDKN2B CDKN2A CDKN1B
6 sodium channel activity GO:0005272 9.26 SCN8A SCN3A SCN2A SCN1A
7 voltage-gated sodium channel activity GO:0005248 8.92 SCN8A SCN3A SCN2A SCN1A

Sources for Low-Grade Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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