MCID: LWT001
MIFTS: 38

Low Tension Glaucoma

Categories: Eye diseases

Aliases & Classifications for Low Tension Glaucoma

MalaCards integrated aliases for Low Tension Glaucoma:

Name: Low Tension Glaucoma 12 55 44 15 73
Normal Tension Glaucoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13544
ICD10 33 H40.12
ICD9CM 35 365.12
MeSH 44 D057066
SNOMED-CT 68 50485007
UMLS 73 C0152136

Summaries for Low Tension Glaucoma

MalaCards based summary : Low Tension Glaucoma, also known as normal tension glaucoma, is related to ocular hypertension and chronic closed-angle glaucoma. An important gene associated with Low Tension Glaucoma is OPTN (Optineurin), and among its related pathways/superpathways is Neuroscience. The drugs Timolol and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes.

Related Diseases for Low Tension Glaucoma

Diseases related to Low Tension Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 ocular hypertension 30.5 MYOC OPTN RHO
2 chronic closed-angle glaucoma 30.3 OPTN PHEX
3 optic nerve disease 30.2 EDN1 MYOC OPTN
4 yemenite deaf-blind hypopigmentation syndrome 30.1 OPTN RHO
5 open-angle glaucoma 29.6 ATOH7 CDKN2B-AS1 GAS7 MYOC OPTN TBK1
6 glaucoma, primary open angle 29.3 ATOH7 CDKN2B-AS1 GAS7 MYOC OPTN PHEX
7 glaucoma, normal tension 11.4
8 glaucoma 1, open angle, p 11.2
9 sleep apnea 10.4
10 alzheimer disease 10.3
11 apnea, obstructive sleep 10.3
12 cataract 10.2
13 retinal vein occlusion 10.2
14 myopia 10.2
15 scotoma 10.2
16 glaucoma 1, open angle, a 10.2 MYOC OPTN
17 excessive tearing 10.2 MYOC OPTN
18 diffuse meningeal melanocytosis 10.2 EDN1 OPTN
19 acute retrobulbar neuritis 10.2 EDN1 RHO
20 corneal edema 10.2 MYOC OPTN
21 3-methylglutaconic aciduria, type iii 10.1
22 traumatic glaucoma 10.1 OPTN PHEX
23 primary angle-closure glaucoma 10.1 MYOC OPTN
24 phacogenic glaucoma 10.1 OPTN PHEX
25 primary congenital glaucoma 10.1 MYOC OPTN WDR36
26 episodic ataxia, type 6 10.1 SLC1A1 SLC1A3
27 iris disease 10.1 OPTN PHEX
28 nervous system disease 10.1 OPTN RHO TBK1
29 dicarboxylic aminoaciduria 10.1 SLC1A1 SLC1A3
30 kearns-sayre syndrome 10.1
31 keratoconus 10.1
32 retinal degeneration 10.1
33 neuropathy 10.0
34 lens disease 10.0 OPTN PHEX
35 glaucoma 3, primary congenital, a 10.0 MYOC OPTN
36 uveal disease 10.0 OPTN PHEX
37 ewing sarcoma 9.9 EDN1 MYOC OPTN RHO
38 adamantinoma of long bones 9.9 CDKN2B-AS1 MYOC OPTN WDR36
39 systemic lupus erythematosus 9.9
40 optic atrophy 1 9.9
41 optic nerve hypoplasia, bilateral 9.9
42 exfoliation syndrome 9.9
43 helicobacter pylori infection 9.9
44 occult macular dystrophy 9.9
45 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
46 atrial fibrillation 9.9
47 sensorineural hearing loss 9.9
48 central retinal vein occlusion 9.9
49 thrombophilia 9.9
50 retinal vascular disease 9.9

Graphical network of the top 20 diseases related to Low Tension Glaucoma:



Diseases related to Low Tension Glaucoma

Symptoms & Phenotypes for Low Tension Glaucoma

Drugs & Therapeutics for Low Tension Glaucoma

Drugs for Low Tension Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 4,Phase 2,Not Applicable 26839-75-8 33624 5478
2
Travoprost Approved Phase 4 157283-68-6 5282226
3
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5
Dipivefrin Approved Phase 4,Not Applicable 52365-63-6 3105
6
Maleic acid Experimental Phase 4 110-16-7 444266
7 Adrenergic alpha-Agonists Phase 4,Phase 2,Not Applicable
8 Antihypertensive Agents Phase 4,Phase 2,Not Applicable
9 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
10 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Not Applicable
11 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
12 Adrenergic Antagonists Phase 4,Phase 2,Not Applicable
13 Adrenergic Agonists Phase 4,Phase 2,Not Applicable
14 Brimonidine Tartrate Phase 4,Phase 2,Not Applicable 70359-46-5
15 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
16 Adrenergic beta-Antagonists Phase 4,Phase 2,Not Applicable
17 Adrenergic Agents Phase 4,Phase 2,Not Applicable
18 Ophthalmic Solutions Phase 4,Phase 2,Not Applicable
19 Pharmaceutical Solutions Phase 4,Phase 2,Not Applicable
20 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Not Applicable
21 Benzalkonium Compounds Phase 4
22 Anti-Infective Agents, Local Phase 4
23 Anti-Infective Agents Phase 4
24
Dorzolamide Approved Phase 2,Not Applicable 120279-96-1 5284549 3154
25
Phenytoin Approved, Vet_approved 57-41-0 1775
26
Latanoprost Approved, Investigational Not Applicable 130209-82-4 5311221 5282380
27 Sodium Channel Blockers
28 Diuretics, Potassium Sparing
29 Convulsants
30 Anticonvulsants
31 Protective Agents
32
Bilirubin 635-65-4 5280352
33 Antioxidants
34 Anesthetics ,Not Applicable
35 Central Nervous System Depressants
36 Proxymetacaine Not Applicable

Interventional clinical trials:

(show top 50) (show all 60)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Combigan and 0.5% Timoptic in Normal Tension Glaucoma Unknown status NCT01446497 Phase 4 Brimonidine/Timolol mixed combination;Timolol
2 Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma Completed NCT01995136 Phase 4 Travoprost Ophthalmic Solution 0.004%
3 Efficacy and Safety of COMBIGAN® in Korean Patients With Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG) Completed NCT02863705 Phase 4 brimonidine tartrate/timolol malate Ophthalmic Solution;bimatoprost ophthalmic solution 0.01%
4 Additive Effect of Twice-daily Brinzolamide 1% / Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma Completed NCT03150160 Phase 4 brinzolamide 1% / brimonidine 0.2%;Placebo
5 Effect of Selective Laser Trabeculoplasty Versus Travoprost on Circardian Intraocular Pressure Completed NCT02105311 Phase 4 Travoprost
6 Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study Active, not recruiting NCT03323164 Phase 4 Timolol Maleate;Brimonidine Tartrate
7 Evaluation of PHP-201 Ophthalmic Solution in Patients With Normal Tension Glaucoma Completed NCT03106532 Phase 2 PHP-201 0.25% ophthalmic solution;PHP-201 0.5% ophthalmic solution;Placebo ophthalmic solution
8 COSOPT (Timolol/Dorzolamide Combination) Normal Tension Glaucoma Study (MK0507A-161)(COMPLETED) Completed NCT00832377 Phase 2 timolol/dorzolamide combination
9 Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma Completed NCT00317577 Phase 2 brimonidine, timolol
10 Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging Recruiting NCT01864317 Phase 2
11 Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient Unknown status NCT00324181
12 Analysis of Clinical Profiles of Chinese Patients With Normal Tension Glaucoma Unknown status NCT00321386
13 Correlation of Orbital Cerebrospinal Fluid Pressure and Retinal Venous Outflow in Primary Open-angle Glaucoma Unknown status NCT01795014
14 Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins Unknown status NCT01794442
15 Normal Tension and Chronic Open Angle Glaucoma and Cerebrospinal Fluid Composition Unknown status NCT00306657 Not Applicable
16 Protective Effect of Phenytoin on Glaucoma Unknown status NCT00739154
17 Blood Flow of Ophthalmic Artery and Glaucoma Unknown status NCT02656979 Not Applicable Latanoprost
18 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913 Not Applicable
19 Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348672
20 Pressure Difference Between Brain and Eye: a Possible Cause to Normal Tension Glaucoma. Completed NCT02776449
21 Intraocular Pressure and Ocular Perfusion Pressure of Cosopt in Normal Tension Glaucoma Completed NCT01175902 Not Applicable dorzolamide/timolol;latanoprost
22 Observational Study of the Long-term Effect of Latanoprost in Normal Tension Glaucoma Completed NCT01209624
23 Serum Bilirubin Levels in Normal-tension Glaucoma Completed NCT03387306
24 Systemic Glutathione Level in Normal Tension Glaucoma Completed NCT00570362
25 Autonomic Nervous System Activity and Normal Tension Glaucoma Completed NCT01192061
26 A New View of Normal Tension Glaucoma: Autoregulation and Systemic Blood Pressure Completed NCT00706056
27 Magnetic Resonance Imaging of Patients With Normal Tension Glaucoma Completed NCT00175786
28 Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Glaucoma Patients Completed NCT01487655
29 Effect of Alphagan on Retinal Blood Flow Autoregulation and Motion Detection in Patients With Normal Pressure Glaucoma Completed NCT01105065 Not Applicable brimonidine 0.15%
30 Spectral Domain Optical Coherence Tomography Analysis for Glaucoma Completed NCT01612416 Not Applicable
31 Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation Completed NCT01391247
32 Pilot Study on Ambulatory Intraocular Pressure and Blood Pressure Monitoring in Glaucoma Completed NCT01912599 Not Applicable
33 Ocular Blood Flow in Glaucoma Patients - the Leuven Eye Study Completed NCT01840202
34 Differences in Nerve Fiber Layer Between Patients With Normal- and High-Pressure-Glaucoma Completed NCT01488032
35 IOP Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic Completed NCT01254149
36 Alcon® Ex-PRESS® Glaucoma Filtration Device in Japanese Patients Completed NCT02246777 Not Applicable
37 Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. Completed NCT00347191
38 Study on Ocular Blood Flow and the Orbital Cerebrospinal Fluid Pressure in Glaucoma Completed NCT01802463
39 Macular Retinoschisis and Detachment Associated With Glaucomatous Optic Neuropathy Completed NCT01862627
40 Relationship Between 24-hour IOP Pattern and the 24-hour Blood Pressure Pattern in Patients With POAG Completed NCT01769521 Not Applicable
41 Evaluation of Corneal Temperature by Infrared Thermography in Glaucoma Patients Completed NCT02674074 Not Applicable
42 Analysis of Visual Pathways in Glaucoma Patients Using a 3tesla-MRI Completed NCT01621841
43 Correlation of Optic Disk Morphology and Ocular Perfusion Parameters in Patients With Primary Open Angle Glaucoma Completed NCT00803504
44 Clinical and Molecular Studies in Families With Glaucoma and Related Diseases Completed NCT00272363
45 Effects of Latanoprost on Choroidal Blood Flow Regulation in Human Subjects Completed NCT00712400 Not Applicable Latanoprost 0.005%, Xalatan®;Placebo
46 Intraocular Pressure and Hemodialysis Midwestern Brazil Completed NCT02405884 Not Applicable
47 Does the Optic Disc Grading Done Visually by Your Doctor Agree With Optic Nerve Testing Which is Done by Machines? Completed NCT00430287
48 Study on the Impact of Ocular Anesthetic Procedures in Ocular Blood Flow Completed NCT01840215
49 Will Listening to Music Make it Easier to Take a Visual Field Test? Completed NCT01027039
50 mRNA Expression in Lymphocytes of Glaucoma Patients Completed NCT00327509

Search NIH Clinical Center for Low Tension Glaucoma

Cochrane evidence based reviews: low tension glaucoma

Genetic Tests for Low Tension Glaucoma

Anatomical Context for Low Tension Glaucoma

MalaCards organs/tissues related to Low Tension Glaucoma:

41
Eye, Brain, Testes, Retina, Bone, Heart, Endothelial

Publications for Low Tension Glaucoma

Articles related to Low Tension Glaucoma:

(show top 50) (show all 725)
# Title Authors Year
1
Managing normal tension glaucoma by lowering the intraocular pressure. ( 30300624 )
2019
2
Intraocular pressure-independent management of normal tension glaucoma. ( 30300625 )
2019
3
Management of normal tension glaucoma. ( 30514477 )
2019
4
Comparison of intraocular pressure fluctuation before and after cataract surgeries in normal-tension glaucoma patients. ( 30255729 )
2018
5
Blood Pressure and Heart Rate Variability in Primary Open-Angle Glaucoma and Normal Tension Glaucoma. ( 30110187 )
2018
6
Intraocular retinal thickness asymmetry in early stage of primary open angle glaucoma and normal tension glaucoma. ( 30140639 )
2018
7
The Association of Single-Nucleotide Polymorphisms in the MMP-9 Gene with Normal Tension Glaucoma and Primary Open-Angle Glaucoma. ( 29199866 )
2018
8
Measurement and Associations of the Optic Nerve Subarachnoid Space in Normal Tension Glaucoma and Primary Open-Angle Glaucoma. ( 29628114 )
2018
9
Oxygen venular saturation correlates with a functional loss in primary open-angle glaucoma and normal-tension glaucoma patients. ( 29090841 )
2018
10
The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan. ( 30038886 )
2018
11
Association between normal tension glaucoma and the risk of Alzheimer's disease: a nationwide population-based cohort study in Taiwan. ( 30397009 )
2018
12
Long-term results of deep sclerectomy in normal-tension glaucoma. ( 28834385 )
2018
13
Diffuse brain damage in normal tension glaucoma. ( 29064608 )
2018
14
Normal-Tension Glaucoma Has Normal Intracranial Pressure: A Prospective Study of Intracranial Pressure and Intraocular Pressure in Different Body Positions. ( 29096996 )
2018
15
Factors associated with deep circulation in the peripapillary chorioretinal atrophy zone in normal-tension glaucoma with myopic disc. ( 29171726 )
2018
16
Flow dynamics of cerebrospinal fluid between the intracranial cavity and the subarachnoid space of the optic nerve measured with a diffusion magnetic resonance imaging sequence in patients with normal tension glaucoma. ( 29178525 )
2018
17
DNA methylation at the 9p21 glaucoma susceptibility locus is associated with normal-tension glaucoma. ( 29265947 )
2018
18
The Efficacy and Safety of the Fixed Combination of Brinzolamide 1% and Brimonidine 0.2% in Normal Tension Glaucoma: An 18-Month Retrospective Study. ( 29297751 )
2018
19
Relationship between corneal biomechanical properties and structural biomarkers in patients with normal-tension glaucoma: a retrospective study. ( 29334923 )
2018
20
Ocular and Clinical Characteristics Associated with the Extent of Posterior Lamina Cribrosa Curve in Normal Tension Glaucoma. ( 29343781 )
2018
21
Heart rate variability in normal tension glaucoma: A case-control study. ( 29384857 )
2018
22
Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma. ( 29385185 )
2018
23
Long-term progression of visual field defects and related factors in medically treated normal tension glaucoma. ( 29440866 )
2018
24
Comparison of retinal microvascular changes in eyes with high-tension glaucoma or normal-tension glaucoma: a quantitative optic coherence tomography angiographic study. ( 29450622 )
2018
25
Results of Nailfold Capillaroscopy in Patients with Normal-Tension Glaucoma. ( 29451988 )
2018
26
Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis. ( 29456252 )
2018
27
Heart rate variability: the comparison between high tension and normal tension glaucoma. ( 29515686 )
2018
28
Impaired cerebrospinal fluid dynamics along the entire optic nerve in normal-tension glaucoma. ( 29532640 )
2018
29
Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study. ( 29593269 )
2018
30
The clinical effectiveness of tafluprost on Japanese normal-tension glaucoma patients. ( 29593379 )
2018
31
The role of corneal hysteresis during the evaluation of patients with possible normal-tension glaucoma. ( 29606853 )
2018
32
White Matter Abnormalities and Correlation With Severity in Normal Tension Glaucoma: A Whole Brain Atlas-Based Diffusion Tensor Study. ( 29625454 )
2018
33
Comparison of Optical Coherence Tomography Angiography and Laser Speckle Flowgraphy for the Diagnosis of Normal-Tension Glaucoma. ( 29651339 )
2018
34
Factors Related to a Right-Left Difference in Visual Field Defect in the Eyes with Untreated Normal Tension Glaucoma. ( 29651342 )
2018
35
Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma. ( 29677370 )
2018
36
Letter to the Editor. Low ICP and normal tension glaucoma: optic nerve damage due to barotraumatic factors, failure of CSF dynamics, or both? ( 29726764 )
2018
37
Re: Lindén et al.: Normal-tension glaucoma has normal intracranial pressure: a prospective study of intracranial pressure and intraocular pressure in different body positions (Ophthalmology. 2018;125:361-368). ( 29784102 )
2018
38
Internal carotid artery aneurysm mimicking normal-tension glaucoma. ( 29846423 )
2018
39
Peripapillary choroidal thickness in untreated normal-tension glaucoma eyes with a single-hemifield retinal nerve fiber layer defect. ( 29879059 )
2018
40
Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging. ( 29879191 )
2018
41
Ocular and Systemic Risk Factors and Correlation with Glaucomatous Damage in Normal Tension Glaucoma. ( 30034960 )
2018
42
Peripapillary and macular choroidal area in patients with normal-tension glaucoma. ( 30212565 )
2018
43
Effect of quantitative intraocular pressure reduction on visual field defect progression in normal tension glaucoma under medical therapy applying Markov model. ( 30214146 )
2018
44
Re: Lindén et al.: Normal-tension glaucoma has normal intracranial pressure: a prospective study of intracranial pressure and intraocular pressure in different body positions (Ophthalmology. 2018;125:361-368). ( 30243345 )
2018
45
Long-term rate of progression and target intraocular pressure in patients with normal-tension glaucoma in clinical care. ( 30259686 )
2018
46
Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review. ( 30275680 )
2018
47
Disc haemorrhages in Polish Caucasian patients with normal tension glaucoma. ( 30284408 )
2018
48
Investigation of whole mitochondrial genome variation in normal tension glaucoma. ( 30312593 )
2018
49
Association of Angle Width With Progression of Normal-Tension Glaucoma: A Minimum 7-Year Follow-up Study. ( 30326036 )
2018
50
Using Kalman Filtering to Forecast Disease Trajectory for Patients with Normal Tension Glaucoma. ( 30336130 )
2018

Variations for Low Tension Glaucoma

Expression for Low Tension Glaucoma

Search GEO for disease gene expression data for Low Tension Glaucoma.

Pathways for Low Tension Glaucoma

Pathways related to Low Tension Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 OPTN RHO SLC1A1 SLC1A3

GO Terms for Low Tension Glaucoma

Biological processes related to Low Tension Glaucoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.67 CDKN2B-AS1 EDN1 TBK1
2 positive regulation of cell migration GO:0030335 9.65 CDKN2B-AS1 EDN1 MYOC
3 response to light stimulus GO:0009416 9.46 RHO SLC1A3
4 positive regulation of heart rate GO:0010460 9.43 EDN1 SLC1A1
5 glutamate secretion GO:0014047 9.4 SLC1A1 SLC1A3
6 L-glutamate transmembrane transport GO:0015813 9.37 SLC1A1 SLC1A3
7 L-glutamate import across plasma membrane GO:0098712 9.32 SLC1A1 SLC1A3
8 positive regulation of xenophagy GO:1904417 9.26 OPTN TBK1
9 D-aspartate import across plasma membrane GO:0070779 9.16 SLC1A1 SLC1A3
10 L-glutamate import GO:0051938 8.96 SLC1A1 SLC1A3
11 L-aspartate import across plasma membrane GO:0140009 8.62 SLC1A1 SLC1A3

Molecular functions related to Low Tension Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 9.32 SLC1A1 SLC1A3
2 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A1 SLC1A3
3 glutamate binding GO:0016595 9.16 SLC1A1 SLC1A3
4 high-affinity glutamate transmembrane transporter activity GO:0005314 8.96 SLC1A1 SLC1A3
5 glutamate:sodium symporter activity GO:0015501 8.62 SLC1A1 SLC1A3

Sources for Low Tension Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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