MCID: LWT001
MIFTS: 34

Low Tension Glaucoma

Categories: Eye diseases

Aliases & Classifications for Low Tension Glaucoma

MalaCards integrated aliases for Low Tension Glaucoma:

Name: Low Tension Glaucoma 12 55 44 15 73
Normal Tension Glaucoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13544
ICD10 33 H40.12
ICD9CM 35 365.12
MeSH 44 D057066
UMLS 73 C0152136

Summaries for Low Tension Glaucoma

MalaCards based summary : Low Tension Glaucoma, also known as normal tension glaucoma, is related to optic nerve disease and ocular hypertension. An important gene associated with Low Tension Glaucoma is OPTN (Optineurin), and among its related pathways/superpathways is Neuroscience. The drugs Timolol and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain.

Related Diseases for Low Tension Glaucoma

Graphical network of the top 20 diseases related to Low Tension Glaucoma:



Diseases related to Low Tension Glaucoma

Symptoms & Phenotypes for Low Tension Glaucoma

Drugs & Therapeutics for Low Tension Glaucoma

Drugs for Low Tension Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 4,Phase 2,Not Applicable 26839-75-8 33624 5478
2
Travoprost Approved Phase 4 157283-68-6 5282226
3
Brinzolamide Approved Phase 4 138890-62-7 68844
4
Dipivefrin Approved Phase 4,Not Applicable 52365-63-6 3105
5
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
6
Maleic acid Experimental Phase 4 110-16-7 444266
7 Adrenergic Agents Phase 4,Phase 2,Not Applicable
8 Adrenergic Agonists Phase 4,Phase 2,Not Applicable
9 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Not Applicable
10 Adrenergic alpha-Agonists Phase 4,Phase 2,Not Applicable
11 Adrenergic Antagonists Phase 4,Phase 2,Not Applicable
12 Adrenergic beta-Antagonists Phase 4,Phase 2,Not Applicable
13 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
14 Antihypertensive Agents Phase 4,Phase 2,Not Applicable
15 Brimonidine Tartrate Phase 4,Phase 2,Not Applicable 70359-46-5
16 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
17 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
18 Ophthalmic Solutions Phase 4,Phase 2,Not Applicable
19 Pharmaceutical Solutions Phase 4,Phase 2,Not Applicable
20 Tetrahydrozoline Phase 4,Not Applicable
21 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Not Applicable
22 Anti-Infective Agents Phase 4
23 Anti-Infective Agents, Local Phase 4
24 Benzalkonium Compounds Phase 4
25
Dorzolamide Approved Phase 2,Not Applicable 120279-96-1 3154 5284549
26
Phenytoin Approved, Vet_approved 57-41-0 1775
27
Latanoprost Approved, Investigational Not Applicable 130209-82-4 5282380 5311221
28
Ephedrine Approved Not Applicable 299-42-3 9294
29
Pseudoephedrine Approved Not Applicable 90-82-4 7028
30 Anticonvulsants
31 Convulsants
32 Diuretics, Potassium Sparing
33 Sodium Channel Blockers
34 Autonomic Agents Not Applicable
35 Nasal Decongestants Not Applicable
36 Peripheral Nervous System Agents Not Applicable
37 Respiratory System Agents Not Applicable
38 Vasoconstrictor Agents Not Applicable
39 Antioxidants
40
Bilirubin 635-65-4 5280352
41 Protective Agents
42 Anesthetics ,Not Applicable
43 Central Nervous System Depressants
44 Proxymetacaine Not Applicable

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Combigan and 0.5% Timoptic in Normal Tension Glaucoma Unknown status NCT01446497 Phase 4 Brimonidine/Timolol mixed combination;Timolol
2 Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma Completed NCT01995136 Phase 4 Travoprost Ophthalmic Solution 0.004%
3 Additive Effect of Twice-daily Brinzolamide 1% / Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma Completed NCT03150160 Phase 4 brinzolamide 1% / brimonidine 0.2%;Placebo
4 Effect of Selective Laser Trabeculoplasty Versus Travoprost on Circardian Intraocular Pressure Completed NCT02105311 Phase 4 Travoprost
5 Efficacy and Safety of COMBIGAN® in Korean Patients With Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG) Active, not recruiting NCT02863705 Phase 4 brimonidine tartrate/timolol malate Ophthalmic Solution;bimatoprost ophthalmic solution 0.01%
6 Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study Active, not recruiting NCT03323164 Phase 4 Timolol Maleate;Brimonidine Tartrate
7 Evaluation of PHP-201 Ophthalmic Solution in Patients With Normal Tension Glaucoma Completed NCT03106532 Phase 2 PHP-201 0.25% ophthalmic solution;PHP-201 0.5% ophthalmic solution;Placebo ophthalmic solution
8 COSOPT (Timolol/Dorzolamide Combination) Normal Tension Glaucoma Study (MK0507A-161)(COMPLETED) Completed NCT00832377 Phase 2 timolol/dorzolamide combination
9 Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma Completed NCT00317577 Phase 2 brimonidine, timolol
10 Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging Recruiting NCT01864317 Phase 2
11 Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient Unknown status NCT00324181
12 Analysis of Clinical Profiles of Chinese Patients With Normal Tension Glaucoma Unknown status NCT00321386
13 Correlation of Orbital Cerebrospinal Fluid Pressure and Retinal Venous Outflow in Primary Open-angle Glaucoma Unknown status NCT01795014
14 Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins Unknown status NCT01794442
15 Normal Tension and Chronic Open Angle Glaucoma and Cerebrospinal Fluid Composition Unknown status NCT00306657 Not Applicable
16 Protective Effect of Phenytoin on Glaucoma Unknown status NCT00739154
17 Blood Flow of Ophthalmic Artery and Glaucoma Unknown status NCT02656979 Not Applicable Latanoprost
18 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913 Not Applicable
19 Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348672
20 Pressure Difference Between Brain and Eye: a Possible Cause to Normal Tension Glaucoma. Completed NCT02776449
21 Intraocular Pressure and Ocular Perfusion Pressure of Cosopt in Normal Tension Glaucoma Completed NCT01175902 Not Applicable dorzolamide/timolol;latanoprost
22 Observational Study of the Long-term Effect of Latanoprost in Normal Tension Glaucoma Completed NCT01209624
23 Serum Bilirubin Levels in Normal-tension Glaucoma Completed NCT03387306
24 Systemic Glutathione Level in Normal Tension Glaucoma Completed NCT00570362
25 Autonomic Nervous System Activity and Normal Tension Glaucoma Completed NCT01192061
26 A New View of Normal Tension Glaucoma: Autoregulation and Systemic Blood Pressure Completed NCT00706056
27 Magnetic Resonance Imaging of Patients With Normal Tension Glaucoma Completed NCT00175786
28 Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Glaucoma Patients Completed NCT01487655
29 Effect of Alphagan on Retinal Blood Flow Autoregulation and Motion Detection in Patients With Normal Pressure Glaucoma Completed NCT01105065 Not Applicable brimonidine 0.15%
30 Spectral Domain Optical Coherence Tomography Analysis for Glaucoma Completed NCT01612416 Not Applicable
31 Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation Completed NCT01391247
32 Pilot Study on Ambulatory Intraocular Pressure and Blood Pressure Monitoring in Glaucoma Completed NCT01912599 Not Applicable
33 Ocular Blood Flow in Glaucoma Patients - the Leuven Eye Study Completed NCT01840202
34 Differences in Nerve Fiber Layer Between Patients With Normal- and High-Pressure-Glaucoma Completed NCT01488032
35 IOP Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic Completed NCT01254149
36 Alcon Ex-PRESS™ Glaucoma Filtration Device in Japanese Patients Completed NCT02246777 Not Applicable
37 Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. Completed NCT00347191
38 Study on Ocular Blood Flow and the Orbital Cerebrospinal Fluid Pressure in Glaucoma Completed NCT01802463
39 Macular Retinoschisis and Detachment Associated With Glaucomatous Optic Neuropathy Completed NCT01862627
40 Relationship Between 24-hour IOP Pattern and the 24-hour Blood Pressure Pattern in Patients With POAG Completed NCT01769521 Not Applicable
41 Evaluation of Corneal Temperature by Infrared Thermography in Glaucoma Patients Completed NCT02674074 Not Applicable
42 Analysis of Visual Pathways in Glaucoma Patients Using a 3tesla-MRI Completed NCT01621841
43 Correlation of Optic Disk Morphology and Ocular Perfusion Parameters in Patients With Primary Open Angle Glaucoma Completed NCT00803504
44 Clinical and Molecular Studies in Families With Glaucoma and Related Diseases Completed NCT00272363
45 Effects of Latanoprost on Choroidal Blood Flow Regulation in Human Subjects Completed NCT00712400 Not Applicable Latanoprost 0.005%, Xalatan®;Placebo
46 Intraocular Pressure and Hemodialysis Midwestern Brazil Completed NCT02405884 Not Applicable
47 Does the Optic Disc Grading Done Visually by Your Doctor Agree With Optic Nerve Testing Which is Done by Machines? Completed NCT00430287
48 Study on the Impact of Ocular Anesthetic Procedures in Ocular Blood Flow Completed NCT01840215
49 Will Listening to Music Make it Easier to Take a Visual Field Test? Completed NCT01027039
50 mRNA Expression in Lymphocytes of Glaucoma Patients Completed NCT00327509

Search NIH Clinical Center for Low Tension Glaucoma

Cochrane evidence based reviews: low tension glaucoma

Genetic Tests for Low Tension Glaucoma

Anatomical Context for Low Tension Glaucoma

MalaCards organs/tissues related to Low Tension Glaucoma:

41
Eye, Testes, Brain

Publications for Low Tension Glaucoma

Articles related to Low Tension Glaucoma:

(show top 50) (show all 115)
# Title Authors Year
1
Identification of the Most Accurate Spectral-domain Optical Coherence Tomography Parameters in Eyes With Early High-Tension and Low-Tension Glaucoma. ( 26950577 )
2016
2
Comparison of the Progression of High- and Low-tension Glaucoma as Determined by Two Different Criteria. ( 26865802 )
2016
3
Gold shunt for refractory advanced low-tension glaucoma with spared central acuity. ( 27051320 )
2016
4
Giant prolactinoma mimicking low-tension glaucoma at presentation. ( 25661749 )
2015
5
Vascular comorbidity in patients with low-tension glaucoma. ( 25044141 )
2014
6
Conjunctival findings in hyperbaric and low-tension glaucoma: an in vivo confocal microscopy study. ( 21955651 )
2012
7
Normal-tension glaucoma (Low-tension glaucoma). ( 21150042 )
2011
8
Progressive hydroxychloroquine toxicity mimicking low-tension glaucoma after discontinuation of the drug. ( 18937815 )
2010
9
Special considerations in low-tension glaucoma. ( 17508037 )
2007
10
Cessation of migraines in a woman with low-tension glaucoma following the use of latanoprost: a favourable side effect? ( 16946757 )
2007
11
Distribution of optineurin sequence variations in an ethnically diverse population of low-tension glaucoma patients from the United States. ( 16988596 )
2006
12
Central corneal thickness in low-tension glaucoma. ( 10604052 )
1999
13
Relationship between cefalo-ophthalmic haemodynamics and visual function in patients affected by carotid stenosis. Possible links with critical low tension glaucoma pictures. ( 9972344 )
1998
14
Low-tension glaucoma disorders. ( 9533598 )
1998
15
The use of flunarizine in the management of low-tension glaucoma: a color Doppler study. ( 9589742 )
1997
16
Color Doppler imaging and plasma levels of endothelin-1 in low-tension glaucoma. ( 9589707 )
1997
17
Reduced ocular pulse amplitude in low tension glaucoma is independent of vasospasm. ( 9425412 )
1997
18
Low tension glaucoma. ( 9211146 )
1997
19
Effect of oral nifedipine on ocular blood flow in patients with low tension glaucoma. ( 9059270 )
1996
20
Normal respiratory chain function in patients with low-tension glaucoma. ( 8573015 )
1996
21
Magnetic resonance imaging in patients with low-tension glaucoma. ( 8540840 )
1996
22
Differences in optic discs in low-tension glaucoma patients with relatively low or high pressures. ( 8883552 )
1996
23
Magnetic resonance imaging in patients with low-tension glaucoma. ( 7575246 )
1995
24
Magnetic resonance imaging in patients with low-tension glaucoma. ( 7864748 )
1995
25
Measurement of ocular blood flow velocity using colour Doppler imaging in low tension glaucoma. ( 7713247 )
1995
26
Comparative study of brain magnetic resonance imaging findings in patients with low-tension glaucoma and control subjects. ( 9098255 )
1995
27
Probability of global indices in low tension glaucoma. ( 8818324 )
1995
28
Low-tension glaucoma. ( 7960512 )
1994
29
Visual and blood flow responses in low-tension glaucoma. ( 7940139 )
1994
30
The effect of increased intraocular pressure on pulsatile ocular blood flow in low tension glaucoma. ( 7940140 )
1994
31
Evaluation of non-invasive carotid studies in patients with low-tension glaucoma. ( 7976279 )
1994
32
Diurnal intraocular pressure variation in low-tension glaucoma. ( 7835445 )
1994
33
Regression analysis of visual field progression in low tension glaucoma. ( 8457519 )
1993
34
Low-tension glaucoma: a comparative study with retinal ischemic syndromes and anterior ischemic optic neuropathy. ( 8115099 )
1993
35
Aqueous humor dynamics in low-tension glaucoma. ( 8238219 )
1993
36
Optic nerve compression by carotid arteries in low-tension glaucoma. ( 8299979 )
1993
37
[Primary open angle glaucoma and low tension glaucoma--pathogenesis and mechanism of optic nerve damage]. ( 1485570 )
1992
38
Low tension glaucoma--its place in modern glaucoma practice. ( 1390534 )
1992
39
Optic disc size in exfoliative, primary open angle, and low-tension glaucoma. ( 1736870 )
1992
40
The vascular factor in low tension glaucoma: alchemists' gold? ( 1739682 )
1992
41
Low-tension glaucoma in identical twins. ( 1463047 )
1992
42
Spectrometric investigations in ocular hypertension and early stages of primary open angle glaucoma and of low tension glaucoma--multisubstance analysis. ( 1428553 )
1992
43
Finger blood flow in patients with low tension glaucoma and primary open-angle glaucoma. ( 1739685 )
1992
44
Low-tension glaucoma. ( 1686844 )
1991
45
Pulsatile ocular blood flow in patients with low tension glaucoma. ( 1873264 )
1991
46
Regression analysis of visual field progression in low tension glaucoma. ( 1873271 )
1991
47
Postural change of intraocular and blood pressures in ocular hypertension and low tension glaucoma. ( 1751457 )
1991
48
Neuroretinal rim area in low tension glaucoma: effect of nifedipine and acetazolamide compared to no treatment. ( 1927310 )
1991
49
[A comparative study on visual field defect in low tension glaucoma]. ( 1950837 )
1991
50
Prevalence of migraine in low-tension glaucoma and primary open-angle glaucoma in Japanese. ( 2021590 )
1991

Variations for Low Tension Glaucoma

Expression for Low Tension Glaucoma

Search GEO for disease gene expression data for Low Tension Glaucoma.

Pathways for Low Tension Glaucoma

Pathways related to Low Tension Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 OPTN RHO SLC1A1 SLC1A3

GO Terms for Low Tension Glaucoma

Biological processes related to Low Tension Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transport GO:0006865 9.48 SLC1A1 SLC1A3
2 response to light stimulus GO:0009416 9.46 RHO SLC1A3
3 glutamate secretion GO:0014047 9.43 SLC1A1 SLC1A3
4 positive regulation of heart rate GO:0010460 9.4 EDN1 SLC1A1
5 L-glutamate transmembrane transport GO:0015813 9.37 SLC1A1 SLC1A3
6 positive regulation of xenophagy GO:1904417 9.32 OPTN TBK1
7 L-glutamate import across plasma membrane GO:0098712 9.26 SLC1A1 SLC1A3
8 D-aspartate import across plasma membrane GO:0070779 9.16 SLC1A1 SLC1A3
9 L-glutamate import GO:0051938 8.96 SLC1A1 SLC1A3
10 L-aspartate import across plasma membrane GO:0140009 8.62 SLC1A1 SLC1A3

Molecular functions related to Low Tension Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 9.32 SLC1A1 SLC1A3
2 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A1 SLC1A3
3 glutamate binding GO:0016595 9.16 SLC1A1 SLC1A3
4 high-affinity glutamate transmembrane transporter activity GO:0005314 8.96 SLC1A1 SLC1A3
5 glutamate:sodium symporter activity GO:0015501 8.62 SLC1A1 SLC1A3

Sources for Low Tension Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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