Lower Lip Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lower Lip Cancer

MalaCards integrated aliases for Lower Lip Cancer:

Name: Lower Lip Cancer ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasms of lip, oral cavity and pharynx

Malignant neoplasm of lip

Malignant neoplasm: External lower lip

External Ids:

Disease Ontology ¹² DOID:8883

ICD10 ³³ C00.1

ICD9CM ³⁵ 140.1

SNOMED-CT ⁶⁸ 94136008

UMLS ⁷³ C0432520

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Summaries for Lower Lip Cancer

MalaCards based summary : Lower Lip Cancer is related to lip cancer and cerebral primitive neuroectodermal tumor. An important gene associated with Lower Lip Cancer is MYCL (MYCL Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include skin, kidney and bone, and related phenotypes are digestive/alimentary and hematopoietic system

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Related Diseases for Lower Lip Cancer

Diseases related to Lower Lip Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)

#	Related Disease	Score	Top Affiliating Genes
1	lip cancer	10.4
2	cerebral primitive neuroectodermal tumor	10.1	MSH2 MYCL
3	nasopharyngeal disease	10.0	CASP3 CD6
4	pharynx cancer	10.0	CASP3 CD6
5	reproductive system disease	10.0	CASP3 MLH1
6	appendix carcinoid tumor	10.0	MLH1 MSH2
7	colorectal cancer, hereditary nonpolyposis, type 7	10.0	MLH1 MSH2
8	adenosquamous colon carcinoma	10.0	MLH1 MSH2
9	sebaceous adenoma	10.0	MLH1 MSH2
10	anal fistula	10.0	MLH1 MSH2
11	melanocytic nevus syndrome, congenital	10.0	MLH1 MSH2
12	childhood kidney cell carcinoma	10.0	MLH1 MSH2
13	colorectal cancer, hereditary nonpolyposis, type 4	10.0	MLH1 MSH2
14	cecum adenocarcinoma	10.0	MLH1 MSH2
15	lynch syndrome i	10.0	MLH1 MSH2
16	sebaceous adenocarcinoma	10.0	MLH1 MSH2
17	intestinal benign neoplasm	10.0	MLH1 MSH2
18	muir-torre syndrome	10.0	MLH1 MSH2
19	keratoacanthoma	10.0	MLH1 MSH2
20	skin benign neoplasm	10.0	MLH1 MSH2
21	small intestine cancer	10.0	MLH1 MSH2
22	mismatch repair cancer syndrome	10.0	MLH1 MSH2
23	colorectal cancer, hereditary nonpolyposis, type 5	10.0	MLH1 MSH2
24	familial colorectal cancer	10.0	MLH1 MSH2
25	colorectal adenoma	10.0	MLH1 MSH2
26	colorectal adenocarcinoma	9.9	MLH1 MSH2
27	fixed drug eruption	9.9	CASP3 IL2
28	stomach disease	9.9	CASP3 MLH1
29	rectal neoplasm	9.9	MLH1 MSH2
30	autosomal genetic disease	9.9	MLH1 MSH2
31	leukocyte disease	9.9	CASP3 IL2
32	endocrine gland cancer	9.9	CASP3 MLH1
33	uterine anomalies	9.8	CASP3 MLH1 MSH2
34	respiratory system disease	9.8	CASP3 IL2
35	colonic disease	9.8	CASP3 MLH1 MSH2
36	female reproductive system disease	9.8	CASP3 MLH1 MSH2
37	gastrointestinal system cancer	9.8	CASP3 MLH1 MSH2
38	autosomal dominant disease	9.8	MLH1 MSH2
39	adamantinoma of long bones	9.8	CASP3 MLH1 MSH2
40	familial adenomatous polyposis	9.8	MLH1 MSH2
41	ulcerative colitis	9.7	IL2 MLH1 MSH2
42	hematologic cancer	9.7	CASP3 IL2 MLH1
43	endometrial cancer	9.7	CASP3 MLH1 MSH2
44	intestinal disease	9.5	CASP3 IL2 MLH1 MSH2
45	gastrointestinal system disease	9.5	CASP3 IL2 MLH1 MSH2
46	large intestine cancer	9.5	CASP3 IL2 MLH1 MSH2

Graphical network of the top 20 diseases related to Lower Lip Cancer:

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Symptoms & Phenotypes for Lower Lip Cancer

MGI Mouse Phenotypes related to Lower Lip Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.46	CASP3 IL2 MLH1 MSH2
2	hematopoietic system	MP:0005397	9.43	CASP3 CD6 IL2 MLH1 MSH2 MYCL
3	immune system	MP:0005387	9.1	CASP3 CD6 IL2 MLH1 MSH2 MYCL

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Drugs & Therapeutics for Lower Lip Cancer

Search Clinical Trials , NIH Clinical Center for Lower Lip Cancer

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Genetic Tests for Lower Lip Cancer

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Anatomical Context for Lower Lip Cancer

MalaCards organs/tissues related to Lower Lip Cancer:

⁴¹

Skin, Kidney, Bone, Colon, Small Intestine, Appendix

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Publications for Lower Lip Cancer

Articles related to Lower Lip Cancer:

(show all 11)

#	Title	Authors	Year
1	Long-term outcome and subjective quality of life after surgical treatment of lower lip cancer. ( 25261402 )	SchA1ller M....Ettl T.	2014
2	Wave technique for treatment of lower lip cancer. ( 22440315 )		2012
3	Is elective neck dissection in T1-2, N0 patients with lower lip cancer necessary? ( 19325341 )		2009
4	Treatment of lower lip cancer: an experience of 48 cases. ( 15617963 )	Salgarelli A.C....Collini M.	2005
5	5 year experience with lower lip cancer. ( 16340275 )		2005
6	Management of lower lip cancer: a retrospective analysis of 118 patients and review of the literature. ( 14623696 )	Lydiatt W.	2003
7	Management of lower lip cancer: a retrospective analysis of 118 patients and review of the literature. ( 12545108 )	Bilkay U....Akin Y.	2003
8	Lower lip cancer morbidity in three regions in South Bulgaria for a period of 15 years (1985-1999). ( 15354490 )		2001
9	Lower lip cancer: Mohs micrographic surgery and reconstruction as a multidisciplinary effort. ( 9251609 )	Zide M.F....Adnot J.	1997
10	Association between development of lower lip cancer and tobacco habits. ( 1653824 )	Blomqvist G....Alberius P.	1991
11	Radiotherapy of lower lip cancer with after-loading and radio-iridium wires. ( 1246451 )	Sinistrero G.	1976

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Genes for Lower Lip Cancer

Genes related to Lower Lip Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYCL	MYCL Proto-Oncogene, BHLH Transcription Factor	Protein Coding	15.45	DISEASES inferred ¹⁵
2	CD6	CD6 Molecule	Protein Coding	14.89	DISEASES inferred ¹⁵
3	MSH2	MutS Homolog 2	Protein Coding	14.26	DISEASES inferred ¹⁵
4	MLH1	MutL Homolog 1	Protein Coding	14.12	DISEASES inferred ¹⁵
5	IL2	Interleukin 2	Protein Coding	13.29	DISEASES inferred ¹⁵
6	CASP3	Caspase 3	Protein Coding	13.2	DISEASES inferred ¹⁵

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Variations for Lower Lip Cancer

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Expression for Lower Lip Cancer

Search GEO for disease gene expression data for Lower Lip Cancer.

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Pathways for Lower Lip Cancer

Pathways related to Lower Lip Cancer according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.4	CASP3 MLH1 MSH2
2	Pathways in cancer ³⁷	11.98	CASP3 IL2 MLH1 MSH2
3	Colorectal Cancer Metastasis ⁶⁴	11.55	CASP3 MLH1 MSH2
4	Mismatch repair ³⁷ ⁶⁶ ¹ Show member pathways Mismatch repair (MMR) directed by MSH2-MSH3 (MutSbeta) ⁶⁶ Mismatch repair (MMR) directed by MSH2-MSH6 (MutSalpha) ⁶⁶ Mismatch Repair in Eukaryotes ⁶⁴	11.5	MLH1 MSH2
5	Corticotropin-releasing hormone signaling pathway ¹	11.46	CASP3 IL2
6	LT-BetaR Pathway ⁶⁴ Show member pathways Apoptosis and survival Lymphotoxin-beta receptor signaling ²²	11.38	CASP3 IL2
7	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.31	CASP3 IL2
8	Integrated Cancer Pathway ¹	11.07	CASP3 MSH2
9	Busulfan Pathway, Pharmacodynamics ⁶¹ Show member pathways Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) ¹ FMO oxidises nucleophiles ⁶⁶	11.01	MLH1 MSH2
10	Doxorubicin Pathway, Pharmacokinetics ⁶¹ Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶¹	10.92	MLH1 MSH2
11	Platinum Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.72	MLH1 MSH2
12	Platinum drug resistance ³⁷	10.66	CASP3 MLH1 MSH2

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GO Terms for Lower Lip Cancer

Cellular components related to Lower Lip Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mismatch repair complex	GO:0032300	8.62	MLH1 MSH2

Biological processes related to Lower Lip Cancer according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to DNA damage stimulus	GO:0006974	9.69	CASP3 MLH1 MSH2
2	positive regulation of T cell proliferation	GO:0042102	9.49	CD6 IL2
3	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.48	MLH1 MSH2
4	extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	9.46	CASP3 IL2
5	mismatch repair	GO:0006298	9.43	MLH1 MSH2
6	response to X-ray	GO:0010165	9.4	CASP3 MSH2
7	somatic hypermutation of immunoglobulin genes	GO:0016446	9.37	MLH1 MSH2
8	isotype switching	GO:0045190	9.32	MLH1 MSH2
9	positive regulation of isotype switching to IgA isotypes	GO:0048298	9.26	MLH1 MSH2
10	somatic recombination of immunoglobulin gene segments	GO:0016447	9.16	MLH1 MSH2
11	somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	8.96	MLH1 MSH2
12	positive regulation of isotype switching to IgG isotypes	GO:0048304	8.8	IL2 MLH1 MSH2

Molecular functions related to Lower Lip Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	single-stranded DNA binding	GO:0003697	9.16	MLH1 MSH2
2	mismatched DNA binding	GO:0030983	8.96	MLH1 MSH2
3	guanine/thymine mispair binding	GO:0032137	8.62	MLH1 MSH2

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Sources for Lower Lip Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia