MCID: LWR001
MIFTS: 28

Lower Lip Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Lower Lip Cancer

MalaCards integrated aliases for Lower Lip Cancer:

Name: Lower Lip Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:8883
ICD9CM 34 140.1
SNOMED-CT 67 94136008
ICD10 32 C00.1
UMLS 70 C0432520

Summaries for Lower Lip Cancer

MalaCards based summary : Lower Lip Cancer is related to lip cancer and extrahepatic bile duct adenoma. An important gene associated with Lower Lip Cancer is MIR345 (MicroRNA 345), and among its related pathways/superpathways are Pathways in cancer and Colorectal Cancer Metastasis. Affiliated tissues include lymph node and tongue, and related phenotype is digestive/alimentary.

Related Diseases for Lower Lip Cancer

Diseases related to Lower Lip Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 lip cancer 10.6
2 extrahepatic bile duct adenoma 10.3 MSH2 MLH1
3 renal pelvis transitional cell carcinoma 10.3 MSH2 MLH1
4 colorectal cancer 2 10.3 MSH2 MLH1
5 adenosquamous colon carcinoma 10.3 MSH2 MLH1
6 rectum signet ring adenocarcinoma 10.3 MSH2 MLH1
7 autosomal dominant non-syndromic intellectual disability 8 10.3 MSH2 MLH1
8 appendix carcinoid tumor 10.3 MSH2 MLH1
9 jejunal cancer 10.3 MSH2 MLH1
10 mismatch repair cancer syndrome 10.2 MSH2 MLH1
11 intracranial meningioma 10.2 MSH2 MLH1
12 ascending colon cancer 10.2 MSH2 MLH1
13 colorectal cancer, hereditary nonpolyposis, type 6 10.2 MSH2 MLH1
14 colorectal cancer, hereditary nonpolyposis, type 5 10.2 MSH2 MLH1
15 sebaceous gland neoplasm 10.2 MSH2 MLH1
16 sebaceous adenoma 10.2 MSH2 MLH1
17 small intestine adenocarcinoma 10.2 MSH2 MLH1
18 duodenum adenocarcinoma 10.2 MSH2 MLH1
19 anal fistula 10.2 MSH2 MLH1
20 dysplastic nevus syndrome 10.2 MSH2 MLH1
21 melanocytic nevus syndrome, congenital 10.2 MSH2 MLH1
22 female reproductive endometrioid cancer 10.1 MSH2 MLH1
23 esophagus sarcoma 10.1 MSH2 CD34
24 cervical adenosarcoma 10.1 MSH2 CD34
25 duodenum cancer 10.1 MSH2 MLH1
26 monophasic synovial sarcoma 10.1 MLH1 CD34
27 mental retardation, autosomal dominant 40 10.1 CXCR4 CD34
28 epiglottis cancer 10.1 ENG CD34
29 intestinal benign neoplasm 10.1 MSH2 MLH1 MIR21
30 gastrointestinal system benign neoplasm 10.1 MSH2 MLH1 MIR21
31 tibial nerve palsy 10.0 ENG CD34
32 colorectal adenoma 10.0 MSH2 MLH1 MIR21
33 capillary lymphangioma 10.0 ENG CD34
34 duodenum disease 10.0 MSH2 MLH1
35 congenital granular cell tumor 10.0 ENG CD34
36 glomeruloid hemangioma 10.0 ENG CD34
37 malignant giant cell tumor of soft parts 10.0 ENG CD34
38 cervix disease 10.0 MIR31 MIR21 MIR181B1
39 aortic valve disease 2 10.0 MIR21 MIR181B1 LPA
40 mobitz type ii atrioventricular block 10.0 ENG CD34
41 skin benign neoplasm 10.0 MSH2 MLH1 CD34
42 spherocytosis, type 5 10.0 CXCR4 CD34
43 cowden syndrome 10.0 MSH2 MLH1 MIR21
44 breast-ovarian cancer, familial 1 9.9 MSH2 MLH1
45 neurofibromatosis, type i 9.9 MSH2 MLH1 CD34
46 keratoacanthoma 9.9 MSH2 MLH1 CASP3
47 rectum cancer 9.9 MSH2 MLH1 MIR31 MIR21
48 cheilitis 9.9
49 speech disorder 9.9
50 48,xyyy 9.9

Graphical network of the top 20 diseases related to Lower Lip Cancer:



Diseases related to Lower Lip Cancer

Symptoms & Phenotypes for Lower Lip Cancer

MGI Mouse Phenotypes related to Lower Lip Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 CASP3 CXCR4 ENG IL2 MLH1 MSH2

Drugs & Therapeutics for Lower Lip Cancer

Search Clinical Trials , NIH Clinical Center for Lower Lip Cancer

Genetic Tests for Lower Lip Cancer

Anatomical Context for Lower Lip Cancer

MalaCards organs/tissues related to Lower Lip Cancer:

40
Lymph Node, Tongue

Publications for Lower Lip Cancer

Articles related to Lower Lip Cancer:

(show top 50) (show all 70)
# Title Authors PMID Year
1
The relevance of miRNAs as promising biomarkers in lip cancer. 61
33439343 2021
2
Lower Lip Cancer Managed by Reconstruction with a Double Abbe Flap - A Case Report. 61
33708599 2020
3
Fusuma Sliding Flap for Lip Reconstruction of Lower Lip Cancer. 61
32209936 2020
4
A Novel Method for Reconstruction of the Lower Lip After Lip Cancer Ablation: Double Abbe Flap. 61
31785249 2020
5
Case report of a huge lower lip cancer successfully treated with intra-arterial infusion chemotherapy. 61
32446228 2020
6
Lip cancer: Reconsidering the at-risk patients with pathological assessment. 61
30548899 2019
7
Total lower lip reconstruction by bilateral Fujimori technique-A case report. 61
31035229 2019
8
The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma. 61
29630749 2018
9
Multiple primary squamous cell carcinomas of the lower lip and tongue arising in discoid lupus erythematosus: a case report. 61
28967499 2018
10
Lower lip squamous cell carcinoma: A Vietnamese case report of surgical treatment with reconstruction by local flap. 61
30567072 2018
11
The prognostic value of CXCR4, α-SMA and WASL in upper lip basal cell carcinomas. 61
30534824 2018
12
Intraoral stents in preventing adverse radiotherapeutic effects in lip cancer patients. 61
28883766 2017
13
Clinicopathological study of lip cancer: a retrospective hospital-based study in Taiwan. 61
28913905 2017
14
Long-term outcomes following post-operative radiotherapy for Stage I/II testicular seminoma - an Australasian single-institution experience. 61
27648280 2016
15
Immunoexpression of cleaved caspase-3 shows lower apoptotic area indices in lip carcinomas than in intraoral cancer. 61
27556207 2016
16
Reconstruction after resection of a lower lip squamous cell carcinoma with a submental island flap. 61
26670761 2015
17
The Value of Sentinel Lymph Node Biopsy in Oral Cavity Cancers. 61
29391982 2015
18
Long-term outcome and subjective quality of life after surgical treatment of lower lip cancer. 61
25261402 2015
19
No evidence for a survival difference between upper and lower lip squamous cell carcinoma. 61
25648936 2015
20
Role of Elective Neck Dissection in Early Stage Lip Cancers. 61
29391973 2015
21
Immunohistochemical analysis of mismatch proteins in carcinogenesis of the lower lip. 61
23865379 2013
22
[Value of spiral CT in diagnosing metastatic lymph node in lower lip cancer]. 61
23944095 2013
23
Wave technique for treatment of lower lip cancer. 61
22440315 2012
24
Lip cancer: retrospective analysis of 181 cases. 61
22136191 2012
25
Lip cancer: incidence, trends, histology and survival: 1970-2006. 61
20163415 2010
26
[Functional reconstruction of total lower lip defect with mental neurovascular V-Y advancement island flap.]. 61
20368036 2010
27
[Approach to the primary mass and neck in lower lip cancers: analysis of 24 cases]. 61
19961400 2009
28
[Oral cancer: morbus Hungaricus in the 21st century]. 61
19514245 2009
29
Is elective neck dissection in T1-2, N0 patients with lower lip cancer necessary? 61
19325341 2009
30
[Upper lip plasty by Karapandzic: modifications of the method]. 61
19491771 2009
31
L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers. 61
18645122 2008
32
[Mental neurovascular V-Y island advancement flap in functional reconstruction of partial lower lip defect]. 61
18437981 2008
33
Reconstruction of the lower lip: rationale to preserve the aesthetic units of the face. 61
17898595 2007
34
[The local and general complications after the lower lip cancer treatment]. 61
17595455 2007
35
[Bernard-Soltan technique in surgical treatment of lower lip cancer]. 61
16813262 2006
36
Treatment of lower lip cancer: an experience of 48 cases. 61
15617963 2005
37
5 year experience with lower lip cancer. 61
16340275 2005
38
[Reconstruction of lower lip resection defect by using Karapandzic technique--early treatment results]. 61
15732778 2004
39
Management of lower lip cancer: a retrospective analysis of 118 patients and review of the literature. 61
14623696 2003
40
Markers of metastasis in lip cancer. 61
12804989 2003
41
Management of lower lip cancer: a retrospective analysis of 118 patients and review of the literature. 61
12545108 2003
42
Is suprahyoid dissection a diagnostic operation in lower lip carcinoma? 61
12071525 2002
43
The potential peril from caliber-persistent arteries of the lips. 61
11807438 2002
44
The staircase technique for treatment of cancer of the lower lip: a report of 36 cases. 61
11289170 2001
45
Lower lip cancer morbidity in three regions in South Bulgaria for a period of 15 years (1985-1999). 61
15354490 2001
46
[Surgical treatment in a case of extensive lower lip cancer]. 61
11766327 2001
47
Tumor thickness as a predictor of cervical lymph node metastasis in squamous cell carcinoma of the lower lip. 61
10629501 2000
48
Lower lip cancer: Mohs micrographic surgery and reconstruction as a multidisciplinary effort. 61
9251609 1997
49
Objective evaluation of function of the lower lip reconstructed with a myocutaneous advancement flap. 61
8850067 1996
50
[The cryodestruction of cancer of the lower lip]. 61
8108824 1993

Variations for Lower Lip Cancer

Expression for Lower Lip Cancer

Search GEO for disease gene expression data for Lower Lip Cancer.

Pathways for Lower Lip Cancer

Pathways related to Lower Lip Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.08 MSH2 MLH1 IL2 CXCR4 CASP3
2 11.76 MSH2 MLH1 CASP3
3 11.67 MIR21 MIR181B1 CASP3
4 11.51 MIR345 MIR31 MIR21 MIR181B1 CASP3
5 11.5 IL2 ENG CD34
6 11.2 MSH2 MLH1 CASP3

GO Terms for Lower Lip Cancer

Cellular components related to Lower Lip Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MSH2 MLH1

Biological processes related to Lower Lip Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.69 MIR31 MIR181B1 IL2
2 positive regulation of inflammatory response GO:0050729 9.63 MIR21 MIR181B1 IL2
3 positive regulation of activated T cell proliferation GO:0042104 9.56 MIR21 IL2
4 negative regulation of innate immune response GO:0045824 9.55 MIR21 MIR181B1
5 positive regulation of endothelial cell differentiation GO:0045603 9.54 MIR21 MIR181B1
6 response to X-ray GO:0010165 9.52 MSH2 CASP3
7 isotype switching GO:0045190 9.49 MSH2 MLH1
8 somatic hypermutation of immunoglobulin genes GO:0016446 9.48 MSH2 MLH1
9 miRNA mediated inhibition of translation GO:0035278 9.46 MIR345 MIR31 MIR21 MIR181B1
10 endothelial tube morphogenesis GO:0061154 9.43 MIR21 CXCR4
11 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.4 MIR21 ENG
12 positive regulation of isotype switching to IgA isotypes GO:0048298 9.37 MSH2 MLH1
13 somatic recombination of immunoglobulin gene segments GO:0016447 9.32 MSH2 MLH1
14 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.26 MSH2 MLH1
15 positive regulation of isotype switching to IgG isotypes GO:0048304 9.13 MSH2 MLH1 IL2
16 positive regulation of angiogenesis GO:0045766 9.02 MIR31 MIR21 MIR181B1 ENG CD34

Molecular functions related to Lower Lip Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.26 MIR345 MIR31 MIR21 MIR181B1
2 mismatched DNA binding GO:0030983 9.16 MSH2 MLH1
3 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Lower Lip Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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