MCID: LWR001
MIFTS: 29

Lower Lip Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Lower Lip Cancer

MalaCards integrated aliases for Lower Lip Cancer:

Name: Lower Lip Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:8883
ICD10 33 C00.1
ICD9CM 35 140.1
UMLS 73 C0432520

Summaries for Lower Lip Cancer

MalaCards based summary : Lower Lip Cancer is related to lip cancer and cerebral primitive neuroectodermal tumor. An important gene associated with Lower Lip Cancer is MYCL (MYCL Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include skin, and related phenotypes are digestive/alimentary and hematopoietic system

Related Diseases for Lower Lip Cancer

Diseases related to Lower Lip Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 lip cancer 10.3
2 cerebral primitive neuroectodermal tumor 10.3 MSH2 MYCL
3 pharynx cancer 10.1 CASP3 CD6
4 appendix carcinoid tumor 10.1 MLH1 MSH2
5 adenosquamous colon carcinoma 10.1 MLH1 MSH2
6 sebaceous adenoma 10.1 MLH1 MSH2
7 anal fistula 10.0 MLH1 MSH2
8 melanocytic nevus syndrome, congenital 10.0 MLH1 MSH2
9 childhood kidney cell carcinoma 10.0 MLH1 MSH2
10 lynch syndrome i 10.0 MLH1 MSH2
11 cecum adenocarcinoma 10.0 MLH1 MSH2
12 sebaceous adenocarcinoma 10.0 MLH1 MSH2
13 small intestine cancer 10.0 MLH1 MSH2
14 muir-torre syndrome 10.0 MLH1 MSH2
15 keratoacanthoma 10.0 MLH1 MSH2
16 intestinal benign neoplasm 10.0 MLH1 MSH2
17 skin benign neoplasm 9.9 MLH1 MSH2
18 mismatch repair cancer syndrome 9.9 MLH1 MSH2
19 familial colorectal cancer 9.9 MLH1 MSH2
20 colorectal adenoma 9.9 MLH1 MSH2
21 hereditary breast ovarian cancer syndrome 9.9 MLH1 MSH2
22 colorectal adenocarcinoma 9.8 MLH1 MSH2
23 autosomal genetic disease 9.8 MLH1 MSH2
24 fixed drug eruption 9.8 CASP3 IL2
25 rectal neoplasm 9.8 MLH1 MSH2
26 familial adenomatous polyposis 9.8 MLH1 MSH2
27 autosomal dominant disease 9.7 MLH1 MSH2
28 cell type cancer 9.5 CASP3 IL2
29 colon adenocarcinoma 9.5 CASP3 MLH1
30 female reproductive organ cancer 9.5 CASP3 MLH1 MSH2
31 gastrointestinal system cancer 9.5 CASP3 MLH1 MSH2
32 adamantinoma of long bones 9.4 CASP3 MLH1 MSH2
33 skin melanoma 9.2 CASP3 MLH1
34 ulcerative colitis 9.1 IL2 MLH1 MSH2
35 colitis 9.1 IL2 MLH1 MSH2
36 hematologic cancer 9.1 CASP3 IL2 MLH1
37 endometrial cancer 9.0 CASP3 MLH1 MSH2

Graphical network of the top 20 diseases related to Lower Lip Cancer:



Diseases related to Lower Lip Cancer

Symptoms & Phenotypes for Lower Lip Cancer

MGI Mouse Phenotypes related to Lower Lip Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.46 IL2 MLH1 MSH2 CASP3
2 hematopoietic system MP:0005397 9.35 CD6 IL2 MSH2 MYCL CASP3
3 immune system MP:0005387 9.02 CASP3 CD6 IL2 MSH2 MYCL

Drugs & Therapeutics for Lower Lip Cancer

Search Clinical Trials , NIH Clinical Center for Lower Lip Cancer

Genetic Tests for Lower Lip Cancer

Anatomical Context for Lower Lip Cancer

MalaCards organs/tissues related to Lower Lip Cancer:

41
Skin

Publications for Lower Lip Cancer

Articles related to Lower Lip Cancer:

(show all 12)
# Title Authors Year
1
Long-term outcome and subjective quality of life after surgical treatment of lower lip cancer. ( 25261402 )
2014
2
Wave technique for treatment of lower lip cancer. ( 22440315 )
2012
3
Is elective neck dissection in T1-2, N0 patients with lower lip cancer necessary? ( 19325341 )
2009
4
L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers. ( 18645122 )
2008
5
Treatment of lower lip cancer: an experience of 48 cases. ( 15617963 )
2005
6
5 year experience with lower lip cancer. ( 16340275 )
2005
7
Management of lower lip cancer: a retrospective analysis of 118 patients and review of the literature. ( 14623696 )
2003
8
Management of lower lip cancer: a retrospective analysis of 118 patients and review of the literature. ( 12545108 )
2003
9
Lower lip cancer morbidity in three regions in South Bulgaria for a period of 15 years (1985-1999). ( 15354490 )
2001
10
Lower lip cancer: Mohs micrographic surgery and reconstruction as a multidisciplinary effort. ( 9251609 )
1997
11
Association between development of lower lip cancer and tobacco habits. ( 1653824 )
1991
12
Radiotherapy of lower lip cancer with after-loading and radio-iridium wires. ( 1246451 )
1976

Variations for Lower Lip Cancer

Expression for Lower Lip Cancer

Search GEO for disease gene expression data for Lower Lip Cancer.

Pathways for Lower Lip Cancer

Pathways related to Lower Lip Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.42 CASP3 MLH1 MSH2
2 11.98 CASP3 IL2 MLH1 MSH2
3 11.55 CASP3 MLH1 MSH2
4
Show member pathways
11.5 MLH1 MSH2
5 11.45 CASP3 IL2
6
Show member pathways
11.38 CASP3 IL2
7
Show member pathways
11.31 CASP3 IL2
8 11.07 CASP3 MSH2
9
Show member pathways
11.01 MLH1 MSH2
10
Show member pathways
10.92 MLH1 MSH2
11 10.72 MLH1 MSH2
12 10.66 CASP3 MLH1 MSH2

GO Terms for Lower Lip Cancer

Cellular components related to Lower Lip Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MLH1 MSH2

Biological processes related to Lower Lip Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.69 CASP3 MLH1 MSH2
2 positive regulation of T cell proliferation GO:0042102 9.49 CD6 IL2
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 MLH1 MSH2
4 mismatch repair GO:0006298 9.46 MLH1 MSH2
5 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 CASP3 IL2
6 response to X-ray GO:0010165 9.4 CASP3 MSH2
7 somatic hypermutation of immunoglobulin genes GO:0016446 9.37 MLH1 MSH2
8 isotype switching GO:0045190 9.32 MLH1 MSH2
9 positive regulation of isotype switching to IgA isotypes GO:0048298 9.26 MLH1 MSH2
10 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MLH1 MSH2
11 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.96 MLH1 MSH2
12 positive regulation of isotype switching to IgG isotypes GO:0048304 8.8 IL2 MLH1 MSH2

Molecular functions related to Lower Lip Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 single-stranded DNA binding GO:0003697 9.16 MLH1 MSH2
2 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
3 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Lower Lip Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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