MCID: LWR004
MIFTS: 26

Lower Urinary Tract Calculus

Categories: Nephrological diseases

Aliases & Classifications for Lower Urinary Tract Calculus

MalaCards integrated aliases for Lower Urinary Tract Calculus:

Name: Lower Urinary Tract Calculus 12 15
Calculus of Lower Urinary Tract 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9590
ICD10 33 N21 N21.9
ICD9CM 35 594 594.9
SNOMED-CT 68 79509009
UMLS 73 C0156264

Summaries for Lower Urinary Tract Calculus

Disease Ontology : 12 A urinary system disease that is located in the lower urinary tract and is characterized by the formation of a stone.

MalaCards based summary : Lower Urinary Tract Calculus, also known as calculus of lower urinary tract, is related to urethral calculus and bladder calculus. An important gene associated with Lower Urinary Tract Calculus is LAGE3 (L Antigen Family Member 3), and among its related pathways/superpathways is tRNA processing. Affiliated tissues include skin, eye and prostate, and related phenotype is Decreased caspase 3/7 activity.

Related Diseases for Lower Urinary Tract Calculus

Diseases related to Lower Urinary Tract Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 urethral calculus 30.7 MCU PLIN1 USF1
2 bladder calculus 29.7 ATP12A ATP4A LAGE3 OSGEP PGRMC1 TP53RK
3 stone in bladder diverticulum 10.5
4 shipyard eye 10.2 OSGEP TP53RK
5 ochronosis 10.2 HGD HPD
6 alkaptonuria 10.2 HGD HPD
7 urethral diverticulum 10.1 HGD MCU
8 fungal esophagitis 10.1 ATP12A ATP4A
9 diclofenac allergy 10.1 ATP12A ATP4A
10 gastroduodenal crohn's disease 10.1 ATP12A ATP4A
11 neonatal candidiasis 10.1 ATP12A ATP4A
12 photoallergic dermatitis 10.1 ATP12A ATP4A
13 squamous papillomatosis 10.1 ATP12A ATP4A
14 toxic megacolon 10.1 ATP12A ATP4A
15 aspiration pneumonitis 10.1 ATP12A ATP4A
16 gastrointestinal neuroendocrine benign tumor 10.1 ATP12A ATP4A
17 gastric antral vascular ectasia 10.1 ATP12A ATP4A
18 granulomatous gastritis 10.1 ATP12A ATP4A
19 esophageal candidiasis 10.1 ATP12A ATP4A
20 gastric neuroendocrine neoplasm 10.1 ATP12A ATP4A
21 acute laryngitis 10.1 ATP12A ATP4A
22 laryngitis 10.1 ATP12A ATP4A
23 duodenitis 10.1 ATP12A ATP4A
24 rumination disorder 10.1 ATP12A ATP4A
25 active peptic ulcer disease 10.1 ATP12A ATP4A
26 congenital disorder of deglycosylation 10.1 ATP12A ATP4A
27 ischemic neuropathy 10.1 ATP12A ATP4A
28 bile reflux 10.1 ATP12A ATP4A
29 capillary disease 10.1 ATP12A ATP4A
30 peptic esophagitis 10.1 ATP12A ATP4A
31 dyskinesia of esophagus 10.1 ATP12A ATP4A
32 anismus 10.1 ATP12A ATP4A
33 intestinal volvulus 10.1 LAGE3 TP53RK TPRKB WDR73
34 postsurgical hypothyroidism 10.1 ATP12A ATP4A
35 lymphocytic colitis 10.1 ATP12A ATP4A
36 esophageal atresia/tracheoesophageal fistula 10.1 ATP12A ATP4A
37 clostridium difficile colitis 10.1 ATP12A ATP4A
38 diarrhea 1, secretory chloride, congenital 10.1 ATP12A ATP4A
39 microscopic colitis 10.1 ATP12A ATP4A
40 laryngeal tuberculosis 10.1 ATP12A ATP4A
41 chronic laryngitis 10.1 ATP12A ATP4A
42 eosinophilic gastritis 10.1 ATP12A ATP4A
43 esophagus adenocarcinoma 10.1 ATP12A ATP4A
44 chronic intestinal vascular insufficiency 10.1 ATP12A ATP4A
45 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1 ATP12A ATP4A
46 jejunoileitis 10.1 ATP12A ATP4A
47 pancreatic steatorrhea 10.1 ATP12A ATP4A
48 esophageal varix 10.1 ATP12A ATP4A
49 duodenal disease 10.0 ATP12A ATP4A
50 gastric lymphoma 10.0 ATP12A ATP4A

Graphical network of the top 20 diseases related to Lower Urinary Tract Calculus:



Diseases related to Lower Urinary Tract Calculus

Symptoms & Phenotypes for Lower Urinary Tract Calculus

GenomeRNAi Phenotypes related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 8.8 AR HGD TP53RK

Drugs & Therapeutics for Lower Urinary Tract Calculus

Search Clinical Trials , NIH Clinical Center for Lower Urinary Tract Calculus

Genetic Tests for Lower Urinary Tract Calculus

Anatomical Context for Lower Urinary Tract Calculus

MalaCards organs/tissues related to Lower Urinary Tract Calculus:

41
Skin, Eye, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Lower Urinary Tract Calculus:

19
The Lower Urinary Tract

Publications for Lower Urinary Tract Calculus

Variations for Lower Urinary Tract Calculus

Expression for Lower Urinary Tract Calculus

Search GEO for disease gene expression data for Lower Urinary Tract Calculus.

Pathways for Lower Urinary Tract Calculus

GO Terms for Lower Urinary Tract Calculus

Cellular components related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 EKC/KEOPS complex GO:0000408 8.92 LAGE3 OSGEP TP53RK TPRKB

Biological processes related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.49 ATP12A ATP4A
2 potassium ion import GO:0010107 9.48 ATP12A ATP4A
3 ATP hydrolysis coupled proton transport GO:0015991 9.46 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.43 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.4 ATP12A ATP4A
6 cellular potassium ion homeostasis GO:0030007 9.37 ATP12A ATP4A
7 sodium ion export across plasma membrane GO:0036376 9.32 ATP12A ATP4A
8 L-phenylalanine catabolic process GO:0006559 9.26 HGD HPD
9 tyrosine catabolic process GO:0006572 9.16 HGD HPD
10 tRNA threonylcarbamoyladenosine modification GO:0002949 8.96 OSGEP TPRKB
11 tRNA processing GO:0008033 8.92 LAGE3 OSGEP TP53RK TPRKB

Molecular functions related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.16 AR PGRMC1
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Lower Urinary Tract Calculus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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