Lower Urinary Tract Calculus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lower Urinary Tract Calculus

MalaCards integrated aliases for Lower Urinary Tract Calculus:

Name: Lower Urinary Tract Calculus ¹² ¹⁵

Calculus of Lower Urinary Tract ⁷³

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the genitourinary system

Urolithiasis

Calculus of lower urinary tract

Calculus of lower urinary tract, unspecified

External Ids:

Disease Ontology ¹² DOID:9590

ICD10 ³³ N21 N21.9

ICD9CM ³⁵ 594 594.9

SNOMED-CT ⁶⁸ 155878002 155881007 197828005 more

UMLS ⁷³ C0156264

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Summaries for Lower Urinary Tract Calculus

Disease Ontology : ¹² A urinary system disease that is located in the lower urinary tract and is characterized by the formation of a stone.

MalaCards based summary : Lower Urinary Tract Calculus, also known as calculus of lower urinary tract, is related to bladder calculus and urethral calculus. An important gene associated with Lower Urinary Tract Calculus is HPD (4-Hydroxyphenylpyruvate Dioxygenase). Affiliated tissues include the lower urinary tract, and related phenotype is homeostasis/metabolism.

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Related Diseases for Lower Urinary Tract Calculus

Diseases related to Lower Urinary Tract Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)

#	Related Disease	Score	Top Affiliating Genes
1	bladder calculus	30.4	ATP12A ATP4A PGRMC1
2	urethral calculus	29.0	F2 FLNA MCU PLIN1 USF1
3	ochronosis	10.8	HGD HPD
4	alkaptonuria	10.7	HGD HPD
5	fungal esophagitis	10.6	ATP12A ATP4A
6	gastrointestinal neuroendocrine benign tumor	10.6	ATP12A ATP4A
7	neonatal candidiasis	10.6	ATP12A ATP4A
8	photoallergic dermatitis	10.6	ATP12A ATP4A
9	squamous papillomatosis	10.6	ATP12A ATP4A
10	acute laryngitis	10.6	ATP12A ATP4A
11	gastroduodenal crohn's disease	10.6	ATP12A ATP4A
12	gastric neuroendocrine neoplasm	10.6	ATP12A ATP4A
13	toxic megacolon	10.6	ATP12A ATP4A
14	aspiration pneumonitis	10.6	ATP12A ATP4A
15	postsurgical hypothyroidism	10.5	ATP12A ATP4A
16	gastric antral vascular ectasia	10.5	ATP12A ATP4A
17	esophageal candidiasis	10.5	ATP12A ATP4A
18	duodenitis	10.5	ATP12A ATP4A
19	rumination disorder	10.5	ATP12A ATP4A
20	bile reflux	10.5	ATP12A ATP4A
21	granulomatous gastritis	10.5	ATP12A ATP4A
22	laryngeal disease	10.5	ATP12A ATP4A
23	postmenopausal atrophic vaginitis	10.5	AR FLNA
24	capillary disease	10.5	ATP12A ATP4A
25	peptic esophagitis	10.5	ATP12A ATP4A
26	duodenal disease	10.5	ATP12A ATP4A
27	dyskinesia of esophagus	10.5	ATP12A ATP4A
28	hernia, hiatus	10.5	ATP12A ATP4A
29	congenital disorder of deglycosylation	10.5	ATP12A ATP4A
30	anismus	10.5	ATP12A ATP4A
31	esophageal atresia/tracheoesophageal fistula	10.5	ATP12A ATP4A
32	laryngitis	10.5	ATP12A ATP4A
33	laryngeal tuberculosis	10.5	ATP12A ATP4A
34	lymphocytic colitis	10.5	ATP12A ATP4A
35	clostridium difficile colitis	10.5	ATP12A ATP4A
36	aspiration pneumonia	10.4	ATP12A ATP4A
37	diarrhea 1, secretory chloride, congenital	10.4	ATP12A ATP4A
38	chronic laryngitis	10.4	ATP12A ATP4A
39	chronic intestinal vascular insufficiency	10.4	ATP12A ATP4A
40	eosinophilic gastritis	10.4	ATP12A ATP4A
41	polyposis, skin pigmentation, alopecia, and fingernail changes	10.4	ATP12A ATP4A
42	esophagus adenocarcinoma	10.4	ATP12A ATP4A
43	myopathy, x-linked, with excessive autophagy	10.4	ATP12A ATP4A
44	gastric lymphoma	10.4	ATP12A ATP4A
45	chronic dacryocystitis	10.4	FLNA PGRMC1
46	pancreatic steatorrhea	10.3	ATP12A ATP4A
47	pneumatosis cystoides intestinalis	10.3	ATP12A ATP4A
48	leech infestation	10.3	F2 FLNA
49	stone in bladder diverticulum	10.3
50	chronic inflammation of lacrimal passage	10.3	FLNA PGRMC1

Graphical network of the top 20 diseases related to Lower Urinary Tract Calculus:

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Symptoms & Phenotypes for Lower Urinary Tract Calculus

MGI Mouse Phenotypes related to Lower Urinary Tract Calculus:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.28	AR ATP12A ATP4A F2 FLNA HGD

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Drugs & Therapeutics for Lower Urinary Tract Calculus

Search Clinical Trials , NIH Clinical Center for Lower Urinary Tract Calculus

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Genetic Tests for Lower Urinary Tract Calculus

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Anatomical Context for Lower Urinary Tract Calculus

The Foundational Model of Anatomy Ontology organs/tissues related to Lower Urinary Tract Calculus:

¹⁹

The Lower Urinary Tract

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Publications for Lower Urinary Tract Calculus

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Genes for Lower Urinary Tract Calculus

Genes related to Lower Urinary Tract Calculus (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HPD	4-Hydroxyphenylpyruvate Dioxygenase	Protein Coding	16.27	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	HGD	Homogentisate 1,2-Dioxygenase	Protein Coding	16.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PLIN1	Perilipin 1	Protein Coding	14.87	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	USF1	Upstream Transcription Factor 1	Protein Coding	14.81	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	FLNA	Filamin A	Protein Coding	14.29	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	13.37	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	13.37	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	AR	Androgen Receptor	Protein Coding	13.33	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	PGRMC1	Progesterone Receptor Membrane Component 1	Protein Coding	13.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	F2	Coagulation Factor II, Thrombin	Protein Coding	13.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	C1orf210	Chromosome 1 Open Reading Frame 210	Protein Coding	5.97	DISEASES inferred ¹⁵
12	MCU	Mitochondrial Calcium Uniporter	Protein Coding	5.47	DISEASES inferred ¹⁵

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Variations for Lower Urinary Tract Calculus

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Expression for Lower Urinary Tract Calculus

Search GEO for disease gene expression data for Lower Urinary Tract Calculus.

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Pathways for Lower Urinary Tract Calculus

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GO Terms for Lower Urinary Tract Calculus

Biological processes related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	potassium ion import	GO:0010107	9.46	ATP12A ATP4A
2	ATP hydrolysis coupled proton transport	GO:0015991	9.43	ATP12A ATP4A
3	cellular sodium ion homeostasis	GO:0006883	9.4	ATP12A ATP4A
4	cellular potassium ion homeostasis	GO:0030007	9.37	ATP12A ATP4A
5	sodium ion export across plasma membrane	GO:0036376	9.32	ATP12A ATP4A
6	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.26	ATP12A ATP4A
7	L-phenylalanine catabolic process	GO:0006559	9.16	HGD HPD
8	negative regulation of fibrinolysis	GO:0051918	8.96	F2 USF1
9	tyrosine catabolic process	GO:0006572	8.62	HGD HPD

Molecular functions related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	steroid binding	GO:0005496	9.16	AR PGRMC1
2	sodium:potassium-exchanging ATPase activity	GO:0005391	8.96	ATP12A ATP4A
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP12A ATP4A

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