Lower Urinary Tract Calculus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lower Urinary Tract Calculus

MalaCards integrated aliases for Lower Urinary Tract Calculus:

Name: Lower Urinary Tract Calculus ¹² ¹⁵

Calculus of Lower Urinary Tract ⁷³

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the genitourinary system

Urolithiasis

Calculus of lower urinary tract

Calculus of lower urinary tract, unspecified

External Ids:

Disease Ontology ¹² DOID:9590

ICD10 ³³ N21 N21.9

ICD9CM ³⁵ 594 594.9

SNOMED-CT ⁶⁸ 79509009

UMLS ⁷³ C0156264

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Summaries for Lower Urinary Tract Calculus

Disease Ontology : ¹² A urinary system disease that is located in the lower urinary tract and is characterized by the formation of a stone.

MalaCards based summary : Lower Urinary Tract Calculus, also known as calculus of lower urinary tract, is related to urethral calculus and bladder calculus. An important gene associated with Lower Urinary Tract Calculus is LAGE3 (L Antigen Family Member 3), and among its related pathways/superpathways is tRNA processing. Affiliated tissues include skin, eye and prostate, and related phenotype is Decreased caspase 3/7 activity.

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Related Diseases for Lower Urinary Tract Calculus

Diseases related to Lower Urinary Tract Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)

#	Related Disease	Score	Top Affiliating Genes
1	urethral calculus	30.7	MCU PLIN1 USF1
2	bladder calculus	29.7	ATP12A ATP4A LAGE3 OSGEP PGRMC1 TP53RK
3	stone in bladder diverticulum	10.5
4	shipyard eye	10.2	OSGEP TP53RK
5	ochronosis	10.2	HGD HPD
6	alkaptonuria	10.2	HGD HPD
7	urethral diverticulum	10.1	HGD MCU
8	fungal esophagitis	10.1	ATP12A ATP4A
9	diclofenac allergy	10.1	ATP12A ATP4A
10	gastroduodenal crohn's disease	10.1	ATP12A ATP4A
11	neonatal candidiasis	10.1	ATP12A ATP4A
12	photoallergic dermatitis	10.1	ATP12A ATP4A
13	squamous papillomatosis	10.1	ATP12A ATP4A
14	toxic megacolon	10.1	ATP12A ATP4A
15	aspiration pneumonitis	10.1	ATP12A ATP4A
16	gastrointestinal neuroendocrine benign tumor	10.1	ATP12A ATP4A
17	gastric antral vascular ectasia	10.1	ATP12A ATP4A
18	granulomatous gastritis	10.1	ATP12A ATP4A
19	esophageal candidiasis	10.1	ATP12A ATP4A
20	gastric neuroendocrine neoplasm	10.1	ATP12A ATP4A
21	acute laryngitis	10.1	ATP12A ATP4A
22	laryngitis	10.1	ATP12A ATP4A
23	duodenitis	10.1	ATP12A ATP4A
24	rumination disorder	10.1	ATP12A ATP4A
25	active peptic ulcer disease	10.1	ATP12A ATP4A
26	congenital disorder of deglycosylation	10.1	ATP12A ATP4A
27	ischemic neuropathy	10.1	ATP12A ATP4A
28	bile reflux	10.1	ATP12A ATP4A
29	capillary disease	10.1	ATP12A ATP4A
30	peptic esophagitis	10.1	ATP12A ATP4A
31	dyskinesia of esophagus	10.1	ATP12A ATP4A
32	anismus	10.1	ATP12A ATP4A
33	intestinal volvulus	10.1	LAGE3 TP53RK TPRKB WDR73
34	postsurgical hypothyroidism	10.1	ATP12A ATP4A
35	lymphocytic colitis	10.1	ATP12A ATP4A
36	esophageal atresia/tracheoesophageal fistula	10.1	ATP12A ATP4A
37	clostridium difficile colitis	10.1	ATP12A ATP4A
38	diarrhea 1, secretory chloride, congenital	10.1	ATP12A ATP4A
39	microscopic colitis	10.1	ATP12A ATP4A
40	laryngeal tuberculosis	10.1	ATP12A ATP4A
41	chronic laryngitis	10.1	ATP12A ATP4A
42	eosinophilic gastritis	10.1	ATP12A ATP4A
43	esophagus adenocarcinoma	10.1	ATP12A ATP4A
44	chronic intestinal vascular insufficiency	10.1	ATP12A ATP4A
45	polyposis, skin pigmentation, alopecia, and fingernail changes	10.1	ATP12A ATP4A
46	jejunoileitis	10.1	ATP12A ATP4A
47	pancreatic steatorrhea	10.1	ATP12A ATP4A
48	esophageal varix	10.1	ATP12A ATP4A
49	duodenal disease	10.0	ATP12A ATP4A
50	gastric lymphoma	10.0	ATP12A ATP4A

Graphical network of the top 20 diseases related to Lower Urinary Tract Calculus:

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Symptoms & Phenotypes for Lower Urinary Tract Calculus

GenomeRNAi Phenotypes related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased caspase 3/7 activity	GR00318-A	8.8	AR HGD TP53RK

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Drugs & Therapeutics for Lower Urinary Tract Calculus

Search Clinical Trials , NIH Clinical Center for Lower Urinary Tract Calculus

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Genetic Tests for Lower Urinary Tract Calculus

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Anatomical Context for Lower Urinary Tract Calculus

MalaCards organs/tissues related to Lower Urinary Tract Calculus:

⁴¹

Skin, Eye, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Lower Urinary Tract Calculus:

¹⁹

The Lower Urinary Tract

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Publications for Lower Urinary Tract Calculus

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Genes for Lower Urinary Tract Calculus

Genes related to Lower Urinary Tract Calculus (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LAGE3	L Antigen Family Member 3	Protein Coding	17.04	DISEASES inferred ¹⁵
2	TPRKB	TP53RK Binding Protein	Protein Coding	16.98	DISEASES inferred ¹⁵
3	TP53RK	TP53 Regulating Kinase	Protein Coding	16.54	DISEASES inferred ¹⁵
4	WDR73	WD Repeat Domain 73	Protein Coding	16.43	DISEASES inferred ¹⁵
5	OSGEP	O-Sialoglycoprotein Endopeptidase	Protein Coding	16.15	DISEASES inferred ¹⁵
6	HPD	4-Hydroxyphenylpyruvate Dioxygenase	Protein Coding	15.15	DISEASES inferred ¹⁵
7	HGD	Homogentisate 1,2-Dioxygenase	Protein Coding	15.02	DISEASES inferred ¹⁵
8	PLIN1	Perilipin 1	Protein Coding	14.75	DISEASES inferred ¹⁵
9	USF1	Upstream Transcription Factor 1	Protein Coding	14.7	DISEASES inferred ¹⁵
10	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	13.26	DISEASES inferred ¹⁵
11	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	13.26	DISEASES inferred ¹⁵
12	AR	Androgen Receptor	Protein Coding	13.1	DISEASES inferred ¹⁵
13	PGRMC1	Progesterone Receptor Membrane Component 1	Protein Coding	13.05	DISEASES inferred ¹⁵
14	MCU	Mitochondrial Calcium Uniporter	Protein Coding	5.32	DISEASES inferred ¹⁵

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Variations for Lower Urinary Tract Calculus

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Expression for Lower Urinary Tract Calculus

Search GEO for disease gene expression data for Lower Urinary Tract Calculus.

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Pathways for Lower Urinary Tract Calculus

Pathways related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	tRNA processing ⁶⁶ Show member pathways 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis ¹ Synthesis of wybutosine at G37 of tRNA(Phe) ⁶⁶ tRNA modification in the mitochondrion ⁶⁶ tRNA modification in the nucleus and cytosol ⁶⁶ tRNA processing in the mitochondrion ⁶⁶ tRNA processing in the nucleus ⁶⁶ wybutosine biosynthesis ¹	11.3	LAGE3 OSGEP TP53RK TPRKB

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GO Terms for Lower Urinary Tract Calculus

Cellular components related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	EKC/KEOPS complex	GO:0000408	8.92	LAGE3 OSGEP TP53RK TPRKB

Biological processes related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	potassium ion import across plasma membrane	GO:1990573	9.49	ATP12A ATP4A
2	potassium ion import	GO:0010107	9.48	ATP12A ATP4A
3	ATP hydrolysis coupled proton transport	GO:0015991	9.46	ATP12A ATP4A
4	cellular sodium ion homeostasis	GO:0006883	9.43	ATP12A ATP4A
5	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.4	ATP12A ATP4A
6	cellular potassium ion homeostasis	GO:0030007	9.37	ATP12A ATP4A
7	sodium ion export across plasma membrane	GO:0036376	9.32	ATP12A ATP4A
8	L-phenylalanine catabolic process	GO:0006559	9.26	HGD HPD
9	tyrosine catabolic process	GO:0006572	9.16	HGD HPD
10	tRNA threonylcarbamoyladenosine modification	GO:0002949	8.96	OSGEP TPRKB
11	tRNA processing	GO:0008033	8.92	LAGE3 OSGEP TP53RK TPRKB

Molecular functions related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	steroid binding	GO:0005496	9.16	AR PGRMC1
2	sodium:potassium-exchanging ATPase activity	GO:0005391	8.96	ATP12A ATP4A
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP12A ATP4A

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