MCID: LWR004
MIFTS: 23

Lower Urinary Tract Calculus

Categories: Nephrological diseases

Aliases & Classifications for Lower Urinary Tract Calculus

MalaCards integrated aliases for Lower Urinary Tract Calculus:

Name: Lower Urinary Tract Calculus 12 15
Calculus of Lower Urinary Tract 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9590
ICD10 33 N21 N21.9
ICD9CM 35 594 594.9
UMLS 73 C0156264

Summaries for Lower Urinary Tract Calculus

Disease Ontology : 12 A urinary system disease that is located in the lower urinary tract and is characterized by the formation of a stone.

MalaCards based summary : Lower Urinary Tract Calculus, also known as calculus of lower urinary tract, is related to bladder calculus and urethral calculus. An important gene associated with Lower Urinary Tract Calculus is HPD (4-Hydroxyphenylpyruvate Dioxygenase). Affiliated tissues include the lower urinary tract, and related phenotype is homeostasis/metabolism.

Related Diseases for Lower Urinary Tract Calculus

Diseases related to Lower Urinary Tract Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 bladder calculus 30.4 ATP12A ATP4A PGRMC1
2 urethral calculus 29.0 F2 FLNA MCU PLIN1 USF1
3 ochronosis 10.8 HGD HPD
4 alkaptonuria 10.7 HGD HPD
5 fungal esophagitis 10.6 ATP12A ATP4A
6 gastrointestinal neuroendocrine benign tumor 10.6 ATP12A ATP4A
7 neonatal candidiasis 10.6 ATP12A ATP4A
8 photoallergic dermatitis 10.6 ATP12A ATP4A
9 squamous papillomatosis 10.6 ATP12A ATP4A
10 acute laryngitis 10.6 ATP12A ATP4A
11 gastroduodenal crohn's disease 10.6 ATP12A ATP4A
12 gastric neuroendocrine neoplasm 10.6 ATP12A ATP4A
13 toxic megacolon 10.6 ATP12A ATP4A
14 aspiration pneumonitis 10.6 ATP12A ATP4A
15 postsurgical hypothyroidism 10.5 ATP12A ATP4A
16 gastric antral vascular ectasia 10.5 ATP12A ATP4A
17 esophageal candidiasis 10.5 ATP12A ATP4A
18 duodenitis 10.5 ATP12A ATP4A
19 rumination disorder 10.5 ATP12A ATP4A
20 bile reflux 10.5 ATP12A ATP4A
21 granulomatous gastritis 10.5 ATP12A ATP4A
22 laryngeal disease 10.5 ATP12A ATP4A
23 postmenopausal atrophic vaginitis 10.5 AR FLNA
24 capillary disease 10.5 ATP12A ATP4A
25 peptic esophagitis 10.5 ATP12A ATP4A
26 duodenal disease 10.5 ATP12A ATP4A
27 dyskinesia of esophagus 10.5 ATP12A ATP4A
28 hernia, hiatus 10.5 ATP12A ATP4A
29 congenital disorder of deglycosylation 10.5 ATP12A ATP4A
30 anismus 10.5 ATP12A ATP4A
31 esophageal atresia/tracheoesophageal fistula 10.5 ATP12A ATP4A
32 laryngitis 10.5 ATP12A ATP4A
33 laryngeal tuberculosis 10.5 ATP12A ATP4A
34 lymphocytic colitis 10.5 ATP12A ATP4A
35 clostridium difficile colitis 10.5 ATP12A ATP4A
36 aspiration pneumonia 10.4 ATP12A ATP4A
37 diarrhea 1, secretory chloride, congenital 10.4 ATP12A ATP4A
38 chronic laryngitis 10.4 ATP12A ATP4A
39 chronic intestinal vascular insufficiency 10.4 ATP12A ATP4A
40 eosinophilic gastritis 10.4 ATP12A ATP4A
41 polyposis, skin pigmentation, alopecia, and fingernail changes 10.4 ATP12A ATP4A
42 esophagus adenocarcinoma 10.4 ATP12A ATP4A
43 myopathy, x-linked, with excessive autophagy 10.4 ATP12A ATP4A
44 gastric lymphoma 10.4 ATP12A ATP4A
45 chronic dacryocystitis 10.4 FLNA PGRMC1
46 pancreatic steatorrhea 10.3 ATP12A ATP4A
47 pneumatosis cystoides intestinalis 10.3 ATP12A ATP4A
48 leech infestation 10.3 F2 FLNA
49 stone in bladder diverticulum 10.3
50 chronic inflammation of lacrimal passage 10.3 FLNA PGRMC1

Graphical network of the top 20 diseases related to Lower Urinary Tract Calculus:



Diseases related to Lower Urinary Tract Calculus

Symptoms & Phenotypes for Lower Urinary Tract Calculus

MGI Mouse Phenotypes related to Lower Urinary Tract Calculus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 AR ATP12A ATP4A F2 FLNA HGD

Drugs & Therapeutics for Lower Urinary Tract Calculus

Search Clinical Trials , NIH Clinical Center for Lower Urinary Tract Calculus

Genetic Tests for Lower Urinary Tract Calculus

Anatomical Context for Lower Urinary Tract Calculus

The Foundational Model of Anatomy Ontology organs/tissues related to Lower Urinary Tract Calculus:

19
The Lower Urinary Tract

Publications for Lower Urinary Tract Calculus

Variations for Lower Urinary Tract Calculus

Expression for Lower Urinary Tract Calculus

Search GEO for disease gene expression data for Lower Urinary Tract Calculus.

Pathways for Lower Urinary Tract Calculus

GO Terms for Lower Urinary Tract Calculus

Biological processes related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import GO:0010107 9.46 ATP12A ATP4A
2 ATP hydrolysis coupled proton transport GO:0015991 9.43 ATP12A ATP4A
3 cellular sodium ion homeostasis GO:0006883 9.4 ATP12A ATP4A
4 cellular potassium ion homeostasis GO:0030007 9.37 ATP12A ATP4A
5 sodium ion export across plasma membrane GO:0036376 9.32 ATP12A ATP4A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP12A ATP4A
7 L-phenylalanine catabolic process GO:0006559 9.16 HGD HPD
8 negative regulation of fibrinolysis GO:0051918 8.96 F2 USF1
9 tyrosine catabolic process GO:0006572 8.62 HGD HPD

Molecular functions related to Lower Urinary Tract Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.16 AR PGRMC1
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Lower Urinary Tract Calculus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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