Lrrk2-Related Parkinson Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lrrk2-Related Parkinson Disease

MalaCards integrated aliases for Lrrk2-Related Parkinson Disease:

Name: Lrrk2-Related Parkinson Disease ²⁴

Lrrk2-Associated Parkinson Disease ²⁴

Parkinson Disease 8 ⁷³

Park8 ²⁴

Characteristics:

GeneReviews:

²⁴

Penetrance Penetrance of lrrk2 pathogenic variants is age dependent but may vary depending on pathogenic variant and population ethnicity...

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Metabolic diseases
Anatomical: Neuronal diseases Mental diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷³ C1846862

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Summaries for Lrrk2-Related Parkinson Disease

MalaCards based summary : Lrrk2-Related Parkinson Disease, also known as lrrk2-associated parkinson disease, is related to parkinson disease, late-onset, and has symptoms including muscle rigidity, bradykinesia and resting tremor. An important gene associated with Lrrk2-Related Parkinson Disease is LRRK2 (Leucine Rich Repeat Kinase 2).

GeneReviews: NBK1208

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Related Diseases for Lrrk2-Related Parkinson Disease

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 1, Autosomal Dominant	Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinson Disease 12	Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinson Disease 3, Autosomal Dominant	Parkinson Disease 4, Autosomal Dominant
Parkinson Disease 6, Autosomal Recessive Early-Onset	Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 10	Parkinson Disease 8, Autosomal Dominant
Parkinson Disease 11, Autosomal Dominant	Parkinson Disease 13, Autosomal Dominant
Parkinson Disease 14, Autosomal Recessive	Parkinson Disease 16
Parkinson Disease 5, Autosomal Dominant	Parkinson Disease 17
Parkinson Disease 18, Autosomal Dominant	Parkinson Disease 19a, Juvenile-Onset
Parkinson Disease 20, Early-Onset	Parkinson Disease 21
Parkinson Disease 22, Autosomal Dominant	Parkinson Disease 23, Autosomal Recessive Early-Onset
Juvenile-Onset Parkinson's Disease	Early-Onset Parkinson's Disease
Lrrk2-Related Parkinson Disease	Vps35-Related Parkinson Disease
Parkinson Disease Type 9	Hereditary Late-Onset Parkinson Disease

Diseases related to Lrrk2-Related Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	parkinson disease, late-onset	10.2

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Symptoms & Phenotypes for Lrrk2-Related Parkinson Disease

UMLS symptoms related to Lrrk2-Related Parkinson Disease:

muscle rigidity, bradykinesia, resting tremor, hyposmia

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Drugs & Therapeutics for Lrrk2-Related Parkinson Disease

Search Clinical Trials , NIH Clinical Center for Lrrk2-Related Parkinson Disease

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Genetic Tests for Lrrk2-Related Parkinson Disease

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Anatomical Context for Lrrk2-Related Parkinson Disease

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Publications for Lrrk2-Related Parkinson Disease

Articles related to Lrrk2-Related Parkinson Disease:

#	Title	Authors	Year
1	Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease. ( 25401511 )	Kalia L.V....Marras C.	2014
2	Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease. ( 20144646 )	Dachsel J.C....Farrer M.J.	2010
3	LRRK2-Related Parkinson Disease ( 20301387 )	Pagon R.A....Stephens K.	1993

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Genes for Lrrk2-Related Parkinson Disease

Genes related to Lrrk2-Related Parkinson Disease (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	LRRK2	Leucine Rich Repeat Kinase 2	Protein Coding	17.84	GeneCards inferred via : Publications (show sections)

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Variations for Lrrk2-Related Parkinson Disease

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Expression for Lrrk2-Related Parkinson Disease

Search GEO for disease gene expression data for Lrrk2-Related Parkinson Disease.

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Pathways for Lrrk2-Related Parkinson Disease

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GO Terms for Lrrk2-Related Parkinson Disease

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Sources for Lrrk2-Related Parkinson Disease

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