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PARK8
MCID: LRR001
MIFTS: 17

Lrrk2-Related Parkinson Disease (PARK8)

Categories: Genetic diseases, Mental diseases, Metabolic diseases, Muscle diseases, Neuronal diseases, Rare diseases
Genes Related diseases Publications Symptoms & Phenotypes
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Aliases & Classifications for Lrrk2-Related Parkinson Disease

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MalaCards integrated aliases for Lrrk2-Related Parkinson Disease:

Name: Lrrk2-Related Parkinson Disease 24
Lrrk2-Associated Parkinson Disease 24
Parkinson Disease 8 73
Park8 24

Characteristics:

GeneReviews:

24
Penetrance Penetrance of lrrk2 pathogenic variants is age dependent but may vary depending on pathogenic variant and population ethnicity...

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Metabolic diseases
Anatomical: Neuronal diseases Muscle diseases Mental diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 73 C1846862
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Summaries for Lrrk2-Related Parkinson Disease

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MalaCards based summary : Lrrk2-Related Parkinson Disease, also known as lrrk2-associated parkinson disease, is related to parkinson disease 8, autosomal dominant and parkinson disease, late-onset, and has symptoms including bradykinesia, hyposmia and resting tremor. An important gene associated with Lrrk2-Related Parkinson Disease is LRRK2 (Leucine Rich Repeat Kinase 2).

GeneReviews: NBK1208
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Related Diseases for Lrrk2-Related Parkinson Disease

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Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 1, Autosomal Dominant Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinson Disease 12 Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinson Disease 3, Autosomal Dominant Parkinson Disease 4, Autosomal Dominant
Parkinson Disease 6, Autosomal Recessive Early-Onset Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 10 Parkinson Disease 8, Autosomal Dominant
Parkinson Disease 11, Autosomal Dominant Parkinson Disease 13, Autosomal Dominant
Parkinson Disease 14, Autosomal Recessive Parkinson Disease 16
Parkinson Disease 5, Autosomal Dominant Parkinson Disease 17
Parkinson Disease 18, Autosomal Dominant Parkinson Disease 19a, Juvenile-Onset
Parkinson Disease 20, Early-Onset Parkinson Disease 21
Parkinson Disease 22, Autosomal Dominant Parkinson Disease 23, Autosomal Recessive Early-Onset
Juvenile-Onset Parkinson's Disease Early-Onset Parkinson's Disease
Lrrk2-Related Parkinson Disease Vps35-Related Parkinson Disease
Parkinson Disease Type 9 Hereditary Late-Onset Parkinson Disease

Diseases related to Lrrk2-Related Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 parkinson disease 8, autosomal dominant 11.2
2 parkinson disease, late-onset 10.3
3 early-onset parkinson's disease 10.1

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Symptoms & Phenotypes for Lrrk2-Related Parkinson Disease

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UMLS symptoms related to Lrrk2-Related Parkinson Disease:


bradykinesia, hyposmia, resting tremor, muscle rigidity
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Drugs & Therapeutics for Lrrk2-Related Parkinson Disease

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Search Clinical Trials , NIH Clinical Center for Lrrk2-Related Parkinson Disease

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Genetic Tests for Lrrk2-Related Parkinson Disease

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Anatomical Context for Lrrk2-Related Parkinson Disease

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Publications for Lrrk2-Related Parkinson Disease

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Articles related to Lrrk2-Related Parkinson Disease:

# Title Authors Year
1
Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease. ( 25401511 )
2014
2
Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease. ( 20144646 )
2010
3
LRRK2-Related Parkinson Disease ( 20301387 )
1993
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Variations for Lrrk2-Related Parkinson Disease

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Expression for Lrrk2-Related Parkinson Disease

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Search GEO for disease gene expression data for Lrrk2-Related Parkinson Disease.
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Pathways for Lrrk2-Related Parkinson Disease

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GO Terms for Lrrk2-Related Parkinson Disease

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Sources for Lrrk2-Related Parkinson Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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