Ludwig's Angina disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ludwig's Angina

MalaCards integrated aliases for Ludwig's Angina:

Name: Ludwig's Angina ¹¹ ⁴³ ¹⁴ ¹⁶ ⁷¹ ⁷⁵

Cellulitis of Floor of Mouth ¹¹

Ludwig Angina ¹¹

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4558

MeSH ⁴³ D008158

SNOMED-CT ⁶⁸ 54572003

EFO ¹⁶ EFO_1000730

UMLS ⁷¹ C0024081

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Summaries for Ludwig's Angina

MalaCards based summary: Ludwig's Angina, also known as cellulitis of floor of mouth, is related to necrotizing fasciitis and angioedema, and has symptoms including oral manifestations An important gene associated with Ludwig's Angina is NCBP3 (Nuclear Cap Binding Subunit 3), and among its related pathways/superpathways are Initial triggering of complement and Immune response Lectin induced complement pathway. Affiliated tissues include tongue, skin and spinal cord.

Wikipedia: ⁷⁵ Ludwig's angina (lat.: Angina ludovici) is a type of severe cellulitis involving the floor of the mouth... more...

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Related Diseases for Ludwig's Angina

Diseases related to Ludwig's Angina via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)

#	Related Disease	Score	Top Affiliating Genes
1	necrotizing fasciitis	30.8	CRP CBLIF
2	angioedema	29.9	CRP C3
3	purpura	29.8	CRP C3
4	angina pectoris	11.3
5	cellulitis	10.8
6	mediastinitis	10.7
7	fasciitis	10.5
8	pleural empyema	10.4
9	dental caries	10.4
10	osteomyelitis	10.3
11	factor viii deficiency	10.2
12	hemophilia a	10.2
13	fanconi anemia, complementation group e	10.2
14	bacteremia 2	10.2
15	dental abscess	10.2
16	sialadenitis	10.2
17	sialolithiasis	10.2
18	pericarditis	10.2
19	haemophilus influenzae	10.2
20	hemophilia	10.2
21	non-histaminic angioedema	10.2
22	vitamin k deficiency bleeding	10.1
23	alcohol dependence	10.0
24	ankyloglossia with or without tooth anomalies	10.0
25	pneumothorax, primary spontaneous	10.0
26	tetralogy of fallot	10.0
27	down syndrome	10.0
28	charge syndrome	10.0
29	inflammatory bowel disease 1	10.0
30	ventricular fibrillation, paroxysmal familial, 1	10.0
31	diabetes mellitus, ketosis-prone	10.0
32	short stature, onychodysplasia, facial dysmorphism, and hypotrichosis	10.0
33	lipoprotein quantitative trait locus	10.0
34	aspiration pneumonia	10.0
35	metabolic acidosis	10.0
36	ameloblastoma	10.0
37	colitis	10.0
38	cardiac arrest	10.0
39	osteonecrosis	10.0
40	dermatomyositis	10.0
41	mumps	10.0
42	parotitis	10.0
43	common cold	10.0
44	disseminated intravascular coagulation	10.0
45	adult respiratory distress syndrome	10.0
46	diphtheria	10.0
47	cardiac tamponade	10.0
48	pericardial effusion	10.0
49	dengue disease	10.0
50	tinea unguium	10.0

Graphical network of the top 20 diseases related to Ludwig's Angina:

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Symptoms & Phenotypes for Ludwig's Angina

UMLS symptoms related to Ludwig's Angina:

oral manifestations

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Drugs & Therapeutics for Ludwig's Angina

Search Clinical Trials, NIH Clinical Center for Ludwig's Angina

Cochrane evidence based reviews: ludwig's angina

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Genetic Tests for Ludwig's Angina

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Anatomical Context for Ludwig's Angina

Organs/tissues related to Ludwig's Angina:

MalaCards : Tongue, Skin, Spinal Cord, Myeloid, Kidney, Bone, Brain

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Publications for Ludwig's Angina

Articles related to Ludwig's Angina:

(show top 50) (show all 397)

#	Title	Authors	PMID	Year
1	Ludwig's Angina an Emergency with Difficult Intubation: A Case Report. ⁶²	Chintale SG...Chintale SS	36452521	2022
2	Anaesthetic Challenges in a Patient of Ludwig's Angina: A Case Report. ⁶²	Movva H...Taksande K	36415440	2022
3	Parapharyngeal and floor-of-mouth abscess secondary to tonsillar phlegmon: A rare and unusual cause of Ludwig's angina. ⁶²	Tailor BV...Ioannidis D	36172328	2022
4	Ludwig's angina: An alarming radiology challenge. ⁶²	Gunawan F...Ferriastuti W	35784784	2022
5	Ludwig's angina in Nigeria: The disease of the poor and health inequality! ⁶²	Osaghae IP...Ayoub A	34187738	2022
6	Apixaban-Induced Pseudo-Ludwig's Angina. ⁶²	Figaro N...Seecheran NA	35836715	2022
7	Rare Angina: A Case Report of Ludwig's Angina. ⁶²	Sakhuja A...Verda L	35836432	2022
8	Extrapulmonary tuberculosis and COVID-19 infection coexisting in concurrent necrotising fasciitis with deep space infection of neck: an unusual presentation. ⁶²	Agarwal SS...Galhotra V	35725284	2022
9	Complications of dental infections due to diagnostic delay during COVID-19 pandemic. ⁶²	Altintas E	35396235	2022
10	Decompression of Ludwig's angina in a pregnant patient under bilateral superficial cervical plexus block. ⁶²	Rahman T...Rahman S	30810488	2022
11	A Terrible Sore Throat: Pharyngitis in an Emergency Department Patient With a Final Diagnosis of Acute Myelogenous Leukemia. ⁶²	Boulet S...Karns C	35464587	2022
12	Management of Ludwig's Angina at a Tertiary Care Hospital in Western Region of India. ⁶²	Parmar BD...Desai RS	35464585	2022
13	Descending necrotizing mediastinitis from Ludwig's angina: a life-threatening condition. ⁶²	Carrascosa MF...Zabaleta-Murguiondo MA	34510302	2022
14	Ludwig's Angina. ⁶²	Romero J...Al-Alwani K	35821904	2022
15	Ludwig's Angina in a Centenarian Patient. ⁶²	Koch KL...Newton F	35345574	2022
16	Ludwig's angina in a COVID positive patient-An atypical case report. ⁶²	Poorna T A...John B	34448220	2022
17	Ketamine-Induced Spontaneous Breathing Intubation With Airway Topicalization: A Case Report of Airway Obstruction in Retrieval Care. ⁶²	Latona A...Hargrave L	35248335	2022
18	Ludwig's angina in a kidney transplant recipient. ⁶²	Romao EA...Moyses Neto M	34268834	2021
19	An Unusual Case of Ludwig's Angina Following Mandibular Fracture. ⁶²	Ozbek L...Farrow A	34963831	2021
20	Clinical and genetic characteristics of PSTPIP1-associated myeloid-related proteinemia inflammatory syndrome. ⁶²	Zhang D...Lai J	34620178	2021
21	Ludwig angina and sudden death. ⁶²	Tu A...Byard RW	33481171	2021
22	Fatal airway obstruction due to Ludwig's angina from severe odontogenic infection during antipsychotic medication: A case report and a literature review. ⁶²	Yamaguchi R...Iwase H	33904596	2021
23	Peritonsillar abscess subsequently complicated by Ludwig's angina. ⁶²	Matsuura N	34485001	2021
24	Severe Ludwig's angina caused by an unknown insect bite. ⁶²	Almadhi G...Almeman A	34417239	2021
25	Ludwig's Angina. ⁶²	Kawataki M...Araki M	33583883	2021
26	Ludwig's angina and steroid therapy. ⁶²	Ito H	32777048	2021
27	Antibacterial mouthwash to prevent sexually transmitted infections in men who have sex with men taking HIV pre-exposure prophylaxis (PReGo): a randomised, placebo-controlled, crossover trial. ⁶²	Van Dijck C...Kenyon C	33676596	2021
28	Ludwig's angina in a rheumatoid arthritis patient taking sarilumab. ⁶²	Shiota S...Miyazaki E	33200168	2021
29	Life-threatening complications of Ludwig's angina: a series of cases in a developed country. ⁶²	Silva CM...Baptista JP	33906886	2021
30	Diagnosis and management of Ludwig's angina: An evidence-based review. ⁶²	Bridwell R...Long B	33383265	2021
31	Management of difficult airway in a pregnant patient with severely reduced mouth opening. ⁶²	Shamim F...Aijaz A	34057966	2021
32	Emergency videoendoscopic endonasal tracheal intubation for severe upper airway stenosis. ⁶²	Tsunoda A...Matsumoto F	33109414	2021
33	[Expert consensus on the treatment of oral and maxillofacial space infections]. ⁶²	Li YP...Kong L	33557496	2021
34	A study of Deep Neck Space Infections at Kathmandu University Dhulikhel Hospital. ⁶²	Pokharel M...Khadka L	34812159	2021
35	An Absorbing Improvement for Space Infection Decompression: A Novel Drainage Device. ⁶²	Bharath A...Madabhushi SSC	34785960	2021
36	Characteristics and outcomes of Ludwig's angina in patients admitted to the intensive care unit: A 6-year retrospective study of 29 patients. ⁶²	Lin QL...Xing XH	33505615	2020
37	Major complications after tongue-tie release: A case report and systematic review. ⁶²	Solis-Pazmino P...Truong MT	32927351	2020
38	Ludwig's angina: infected teeth must be extracted. ⁶²	Cousin GC...Yousaf I	33208308	2020
39	Management of pediatric head and neck infections in the emergency department. ⁶²	Abudinen-Vasquez S...Marin MN	33105074	2020
40	Ludwig's Angina in Pregnancy: A Case Report. ⁶²	Trahan MJ...Wou K	32631786	2020
41	Ludwig's angina. ⁶²	Miah MR...Ali AS	32917993	2020
42	Acute Adult Supraglottitis: An Impending Threat to Patency of Airway and Life. ⁶²	Shaikh N...Al Maslamani M	32983678	2020
43	Delay in the Referral of Pregnant Patients with Fascial Spaces Infection: A Cross-Sectional Observational Study from Khartoum Teaching Dental Hospital, Sudan. ⁶²	Ali EAM...Osman MAK	32346243	2020
44	Sialolithiasis with abscess: An uncommon presentation of a Ludwig's angina mimic. ⁶²	Bridwell RE...Long B	31926666	2020
45	Ludwig's angina. ⁶²	Wu ST	31589319	2020
46	Ludwig's angina and steroid use: A narrative review. ⁶²	Tami A...McKinnon BJ	32035654	2020
47	Ludwig's angina: A diagnostic and surgical priority. ⁶²	Vallee M...Asseray N	31981767	2020
48	A Severe Case of Ludwig's Angina with a Complicated Clinical Course. ⁶²	Kovalev V	32431974	2020
49	The management of septic shock and Ludwig's angina: A case report of a life-threatening condition. ⁶²	Sjamsudin E...Maulina T	32728440	2020
50	Successful Management of Ludwig's Angina due to Dental Implant Displacement: A Rare Case Report. ⁶²	Cardoso LL...Marao HF	32148975	2020

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Genes for Ludwig's Angina

Genes related to Ludwig's Angina (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NCBP3	Nuclear Cap Binding Subunit 3	Protein Coding	6.37	DISEASES inferred ¹⁴
2	EGFL8	EGF Like Domain Multiple 8	Protein Coding	5.64	DISEASES inferred ¹⁴
3	CBLIF	Cobalamin Binding Intrinsic Factor	Protein Coding	5.35	DISEASES inferred ¹⁴
4	CRP	C-Reactive Protein	Protein Coding	5.26	DISEASES inferred ¹⁴
5	PSTPIP1	Proline-Serine-Threonine Phosphatase Interacting Protein 1	Protein Coding	4.78	DISEASES inferred ¹⁴
6	C3	Complement C3	Protein Coding	4.29	DISEASES inferred ¹⁴
7	BHLHE40	Basic Helix-Loop-Helix Family Member E40	Protein Coding	4.24	DISEASES inferred ¹⁴

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Variations for Ludwig's Angina

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Expression for Ludwig's Angina

Search GEO for disease gene expression data for Ludwig's Angina.

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Pathways for Ludwig's Angina

Pathways related to Ludwig's Angina according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Initial triggering of complement ⁶⁶ Show member pathways Alternative complement activation ⁶⁶ Alternative Complement Pathway ⁶⁴ Classical antibody-mediated complement activation ⁶⁶ Complement activation ⁷⁴ Complement Activation Pathways ⁶⁷ Creation of C4 and C2 activators ⁶⁶ Ficolins bind to repetitive carbohydrate structures on the target cell surface ⁶⁶ Lectin pathway of complement activation ⁶⁶	11.32	CRP C3
2	Immune response Lectin induced complement pathway ²² Show member pathways Immune response Alternative complement pathway ²² Immune response Classical complement pathway ²² Terminal pathway of complement ⁶⁶	11.19	CRP C3
3	Inflammasomes ⁶⁶ Show member pathways Cell recruitment (pro-inflammatory response) ⁶⁶ Influenza A virus infection ⁷⁴ Interleukin-1 processing ⁶⁶ Purinergic signaling in leishmaniasis infection ⁶⁶ The AIM2 inflammasome ⁶⁶ The NLRP1 inflammasome ⁶⁶ The NLRP3 inflammasome ⁶⁶	10.98	PSTPIP1 C3
4	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	10.47	CRP C3

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GO Terms for Ludwig's Angina

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Sources for Ludwig's Angina

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LDW001 MIFTS: 27	Ludwig's Angina Categories: Skin diseases	Data Licensing For inquiries, contact: [email protected]
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