Lujan Syndrome (LFS)

NIH Rare Diseases : ⁵³ Lujan syndrome is a condition characterized by intellectual disability, behavioral problems, and poor muscle tone (hypotonia). Affected people also tend to have characteristic physical features such as a tall and thin body; a large head (macrocephaly); and a thin face with distinctive facial features (prominent top of the nose, short space between the nose and the upper lip, narrow roof of the mouth, crowded teeth and a small chin). Most of the cases occur in males. Lujan syndrome is caused by changes (mutations) in the MED12 gene and is inherited in an X-linked manner. Treatment is based on the signs and symptoms present in each person and may include special education; physical therapy, occupational therapy, and speech therapy for developmental delays; and medications to control seizures.

MalaCards based summary : Lujan Syndrome, also known as x-linked mental retardation with marfanoid habitus syndrome, is related to li-fraumeni syndrome and lassa fever. An important gene associated with Lujan Syndrome is MED12 (Mediator Complex Subunit 12). Affiliated tissues include brain.

Genetics Home Reference : ²⁵ Lujan syndrome is a condition characterized by intellectual disability, behavioral problems, and certain physical features. It occurs almost exclusively in males.

Search Clinical Trials , NIH Clinical Center for Lujan Syndrome

Search GEO for disease gene expression data for Lujan Syndrome.