Lujo Hemorrhagic Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ Lujo hemorrhagic fever, caused by the Lujo virus (a newly discovered Old World arenavirus) is a zoonotic disease from Zambia, Africa, whose reservoir is unknown and is characterized by fever and hemorrhagic manifestations with an extremely high fatality rate of 80% (in the 5 reported cases to date) and a moderate to high level of nosocomial transmission.

MalaCards based summary: Lujo Hemorrhagic Fever, also known as zambian hemorrhagic fever, is related to ebola hemorrhagic fever and lassa fever, and has symptoms including bleeding An important gene associated with Lujo Hemorrhagic Fever is MBTPS1 (Membrane Bound Transcription Factor Peptidase, Site 1). Affiliated tissues include skin, and related phenotypes are fever and elevated hepatic transaminase

CDC: ² Lujo hemorrhagic fever (LUHF) is caused by Lujo virus, a single-stranded virus of the Arenaviridae family. The limited clinical information about LUHF comes from a small, nosocomial cluster of hemorrhagic disease in September-October 2008 involving 5 patients in South Africa. The case fatality rate was 80% (4/5 cases).

Disease Ontology: ¹¹ A viral infectious disease that results in infection, has material basis in Lujo virus, which has symptom bleeding.

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Related Diseases for Lujo Hemorrhagic Fever

Diseases related to Lujo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)

#	Related Disease	Score	Top Affiliating Genes
1	ebola hemorrhagic fever	29.9	GTPBP1 GP2
2	lassa fever	29.6	MBTPS1 GTPBP1 GP2 DAG1
3	exanthem	10.2
4	disseminated intravascular coagulation	10.2
5	viral infectious disease	10.2
6	blessig's cysts	9.9	GTPBP1 GP2
7	crimean-congo hemorrhagic fever	9.9	MBTPS1 GTPBP1
8	de quervain disease	9.9	GTPBP1 GP2
9	marburg hemorrhagic fever	9.9	GTPBP1 GP2
10	stuttering	9.7	GTPBP1 GP2
11	brazilian hemorrhagic fever	9.5	MBTPS1 GTPBP1 GP2 DAG1
12	venezuelan hemorrhagic fever	9.5	MBTPS1 GTPBP1 GP2 DAG1
13	bolivian hemorrhagic fever	9.5	MBTPS1 GTPBP1 GP2 DAG1
14	argentine hemorrhagic fever	9.4	MBTPS1 GTPBP1 GP2 DAG1

Graphical network of the top 20 diseases related to Lujo Hemorrhagic Fever:

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Symptoms & Phenotypes for Lujo Hemorrhagic Fever

Human phenotypes related to Lujo Hemorrhagic Fever:

⁵⁸ ³⁰ (show top 50) (show all 61)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	fever ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001945
2	elevated hepatic transaminase ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002910
3	thrombocytopenia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001873
4	myalgia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0003326
5	headache ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002315
6	diarrhea ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002014
7	pharyngitis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0025439
8	stiff neck ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0025258
9	severe viral infection ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0031691
10	vomiting ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002013
11	renal insufficiency ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000083
12	lymphopenia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001888
13	chest pain ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100749
14	metabolic acidosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001942
15	coma ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001259
16	leukopenia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001882
17	oliguria ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100520
18	leukocytosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001974
19	confusion ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001289
20	microscopic hematuria ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002907
21	maculopapular exanthema ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0040186
22	ecchymosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031364
23	shock ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031273
24	nausea ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002018
25	prolonged partial thromboplastin time ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0003645
26	generalized edema ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0007430
27	subconjunctival hemorrhage ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0011896
28	increased circulating lactate dehydrogenase concentration ³⁰	Frequent (33%)		HP:0025435
29	elevated circulating c-reactive protein concentration ³⁰	Frequent (33%)		HP:0011227
30	hyperhidrosis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000975
31	dysphagia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002015
32	hypotension ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002615
33	muscle weakness ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001324
34	photophobia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000613
35	anxiety ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000739
36	atelectasis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100750
37	periorbital edema ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100539
38	mental deterioration ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001268
39	peripheral neuropathy ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0009830
40	myocarditis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0012819
41	bilateral tonic-clonic seizure ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002069
42	respiratory distress ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002098
43	drowsiness ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002329
44	rhinitis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0012384
45	bradycardia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001662
46	cerebral edema ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002181
47	resting tremor ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002322
48	fulminant hepatitis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0004787
49	rigors ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0025145
50	excessive bleeding after a venipuncture ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0030139

Symptoms:

¹¹

• bleeding

GenomeRNAi Phenotypes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

²⁵ (show all 15)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-111	9.53	GTPBP1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	9.53	DAG1 GTPBP1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-13	9.53	DAG1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	9.53	DAG1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-145	9.53	DAG1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-148	9.53	GTPBP1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.53	GTPBP1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-195	9.53	DAG1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.53	DAG1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	9.53	GTPBP1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-20	9.53	DAG1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.53	DAG1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.53	DAG1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-48	9.53	GTPBP1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.53	GTPBP1

MGI Mouse Phenotypes related to Lujo Hemorrhagic Fever:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal	MP:0002873	8.92	CACNA2D2 DAG1 GP2 GTPBP1

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Drugs & Therapeutics for Lujo Hemorrhagic Fever

Search Clinical Trials, NIH Clinical Center for Lujo Hemorrhagic Fever

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Genetic Tests for Lujo Hemorrhagic Fever

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Anatomical Context for Lujo Hemorrhagic Fever

Organs/tissues related to Lujo Hemorrhagic Fever:

MalaCards : Skin

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Publications for Lujo Hemorrhagic Fever

Articles related to Lujo Hemorrhagic Fever:

#	Title	Authors	PMID	Year
1	[Lujo hemorrhagic fever]. ⁶²	Sizikova TE...Borisevich SV	29733163	2017
2	Clinical features and patient management of Lujo hemorrhagic fever. ⁶²	Sewlall NH...Bausch D	25393244	2014

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Genes for Lujo Hemorrhagic Fever

Genes related to Lujo Hemorrhagic Fever (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MBTPS1	Membrane Bound Transcription Factor Peptidase, Site 1	Protein Coding	5.62	DISEASES inferred ¹⁴
2	GTPBP1	GTP Binding Protein 1	Protein Coding	5.39	DISEASES inferred ¹⁴
3	GP2	Glycoprotein 2	Protein Coding	5.23	DISEASES inferred ¹⁴
4	MTPN	Myotrophin	Protein Coding	4.66	DISEASES inferred ¹⁴
5	CACNA2D2	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2	Protein Coding	4.65	DISEASES inferred ¹⁴
6	DAG1	Dystroglycan 1	Protein Coding	4.54	DISEASES inferred ¹⁴

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Variations for Lujo Hemorrhagic Fever

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Expression for Lujo Hemorrhagic Fever

Search GEO for disease gene expression data for Lujo Hemorrhagic Fever.

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Pathways for Lujo Hemorrhagic Fever

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GO Terms for Lujo Hemorrhagic Fever

Biological processes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to mechanical stimulus	GO:0071260	9.26	MTPN DAG1
2	skeletal muscle tissue regeneration	GO:0043403	8.92	MTPN DAG1

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Sources for Lujo Hemorrhagic Fever

¹ BitterDB

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⁵ ClinVar

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⁸ Cosmic

⁹ dbSNP

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¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LJH001 MIFTS: 28	Lujo Hemorrhagic Fever Categories: Infectious diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Lujo Hemorrhagic Fever

Aliases & Classifications for Lujo Hemorrhagic Fever

MalaCards integrated aliases for Lujo Hemorrhagic Fever:

Characteristics:

Age Of Onset:

Classifications:

External Ids:

Summaries for Lujo Hemorrhagic Fever

Related Diseases for Lujo Hemorrhagic Fever

Diseases related to Lujo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Lujo Hemorrhagic Fever:

Symptoms & Phenotypes for Lujo Hemorrhagic Fever

Human phenotypes related to Lujo Hemorrhagic Fever:

Symptoms:

GenomeRNAi Phenotypes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Lujo Hemorrhagic Fever:

Drugs & Therapeutics for Lujo Hemorrhagic Fever

Genetic Tests for Lujo Hemorrhagic Fever

Anatomical Context for Lujo Hemorrhagic Fever

Organs/tissues related to Lujo Hemorrhagic Fever:

Publications for Lujo Hemorrhagic Fever

Articles related to Lujo Hemorrhagic Fever:

Genes for Lujo Hemorrhagic Fever

Genes related to Lujo Hemorrhagic Fever (0 elite genes):

Variations for Lujo Hemorrhagic Fever

Expression for Lujo Hemorrhagic Fever

Pathways for Lujo Hemorrhagic Fever

GO Terms for Lujo Hemorrhagic Fever

Biological processes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

Sources for Lujo Hemorrhagic Fever