MCID: LJH001
MIFTS: 28

Lujo Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases
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Aliases & Classifications for Lujo Hemorrhagic Fever

Summaries for Lujo Hemorrhagic Fever

Orphanet: 58 Lujo hemorrhagic fever, caused by the Lujo virus (a newly discovered Old World arenavirus) is a zoonotic disease from Zambia, Africa, whose reservoir is unknown and is characterized by fever and hemorrhagic manifestations with an extremely high fatality rate of 80% (in the 5 reported cases to date) and a moderate to high level of nosocomial transmission.

MalaCards based summary: Lujo Hemorrhagic Fever, also known as zambian hemorrhagic fever, is related to ebola hemorrhagic fever and lassa fever, and has symptoms including bleeding An important gene associated with Lujo Hemorrhagic Fever is MBTPS1 (Membrane Bound Transcription Factor Peptidase, Site 1). Affiliated tissues include skin, and related phenotypes are fever and elevated hepatic transaminase

CDC: 2 Lujo hemorrhagic fever (LUHF) is caused by Lujo virus, a single-stranded virus of the Arenaviridae family. The limited clinical information about LUHF comes from a small, nosocomial cluster of hemorrhagic disease in September-October 2008 involving 5 patients in South Africa. The case fatality rate was 80% (4/5 cases).

Disease Ontology: 11 A viral infectious disease that results in infection, has material basis in Lujo virus, which has symptom bleeding.

Related Diseases for Lujo Hemorrhagic Fever

Graphical network of the top 20 diseases related to Lujo Hemorrhagic Fever:



Diseases related to Lujo Hemorrhagic Fever

Symptoms & Phenotypes for Lujo Hemorrhagic Fever

Human phenotypes related to Lujo Hemorrhagic Fever:

58 30 (show top 50) (show all 61)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001945
2 elevated hepatic transaminase 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002910
3 thrombocytopenia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001873
4 myalgia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0003326
5 headache 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002315
6 diarrhea 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002014
7 pharyngitis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0025439
8 stiff neck 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0025258
9 severe viral infection 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0031691
10 vomiting 58 30 Frequent (33%) Frequent (79-30%)
HP:0002013
11 renal insufficiency 58 30 Frequent (33%) Frequent (79-30%)
HP:0000083
12 lymphopenia 58 30 Frequent (33%) Frequent (79-30%)
HP:0001888
13 chest pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0100749
14 metabolic acidosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0001942
15 coma 58 30 Frequent (33%) Frequent (79-30%)
HP:0001259
16 leukopenia 58 30 Frequent (33%) Frequent (79-30%)
HP:0001882
17 oliguria 58 30 Frequent (33%) Frequent (79-30%)
HP:0100520
18 leukocytosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0001974
19 confusion 58 30 Frequent (33%) Frequent (79-30%)
HP:0001289
20 microscopic hematuria 58 30 Frequent (33%) Frequent (79-30%)
HP:0002907
21 maculopapular exanthema 58 30 Frequent (33%) Frequent (79-30%)
HP:0040186
22 ecchymosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0031364
23 shock 58 30 Frequent (33%) Frequent (79-30%)
HP:0031273
24 nausea 58 30 Frequent (33%) Frequent (79-30%)
HP:0002018
25 prolonged partial thromboplastin time 58 30 Frequent (33%) Frequent (79-30%)
HP:0003645
26 generalized edema 58 30 Frequent (33%) Frequent (79-30%)
HP:0007430
27 subconjunctival hemorrhage 58 30 Frequent (33%) Frequent (79-30%)
HP:0011896
28 increased circulating lactate dehydrogenase concentration 30 Frequent (33%) HP:0025435
29 elevated circulating c-reactive protein concentration 30 Frequent (33%) HP:0011227
30 hyperhidrosis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000975
31 dysphagia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002015
32 hypotension 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002615
33 muscle weakness 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001324
34 photophobia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000613
35 anxiety 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000739
36 atelectasis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100750
37 periorbital edema 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100539
38 mental deterioration 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001268
39 peripheral neuropathy 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0009830
40 myocarditis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0012819
41 bilateral tonic-clonic seizure 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002069
42 respiratory distress 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002098
43 drowsiness 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002329
44 rhinitis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0012384
45 bradycardia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001662
46 cerebral edema 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002181
47 resting tremor 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002322
48 fulminant hepatitis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0004787
49 rigors 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0025145
50 excessive bleeding after a venipuncture 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0030139

Symptoms:

11
  • bleeding

GenomeRNAi Phenotypes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

25 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.53 GTPBP1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.53 DAG1 GTPBP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.53 DAG1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 DAG1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.53 DAG1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.53 GTPBP1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.53 GTPBP1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.53 DAG1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.53 DAG1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.53 GTPBP1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.53 DAG1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.53 DAG1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.53 DAG1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.53 GTPBP1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.53 GTPBP1

MGI Mouse Phenotypes related to Lujo Hemorrhagic Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 8.92 CACNA2D2 DAG1 GP2 GTPBP1

Drugs & Therapeutics for Lujo Hemorrhagic Fever

Search Clinical Trials, NIH Clinical Center for Lujo Hemorrhagic Fever

Genetic Tests for Lujo Hemorrhagic Fever

Anatomical Context for Lujo Hemorrhagic Fever

Organs/tissues related to Lujo Hemorrhagic Fever:

MalaCards : Skin

Publications for Lujo Hemorrhagic Fever

Articles related to Lujo Hemorrhagic Fever:

# Title Authors PMID Year
1
[Lujo hemorrhagic fever]. 62
29733163 2017
2
Clinical features and patient management of Lujo hemorrhagic fever. 62
25393244 2014

Variations for Lujo Hemorrhagic Fever

Expression for Lujo Hemorrhagic Fever

Search GEO for disease gene expression data for Lujo Hemorrhagic Fever.

Pathways for Lujo Hemorrhagic Fever

GO Terms for Lujo Hemorrhagic Fever

Biological processes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to mechanical stimulus GO:0071260 9.26 MTPN DAG1
2 skeletal muscle tissue regeneration GO:0043403 8.92 MTPN DAG1

Sources for Lujo Hemorrhagic Fever

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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