MCID: LJH001
MIFTS: 31

Lujo Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lujo Hemorrhagic Fever

Summaries for Lujo Hemorrhagic Fever

CDC : 3 Lujo hemorrhagic fever (LUHF) is caused by Lujo virus, a single-stranded virus of the Arenaviridae family. The limited clinical information about LUHF comes from a small, nosocomial cluster of hemorrhagic disease in September-October 2008 involving 5 patients in South Africa. The case fatality rate was 80% (4/5 cases).

MalaCards based summary : Lujo Hemorrhagic Fever, also known as zambian hemorrhagic fever, is related to exanthem and lassa fever, and has symptoms including bleeding An important gene associated with Lujo Hemorrhagic Fever is GOT1 (Glutamic-Oxaloacetic Transaminase 1), and among its related pathways/superpathways are Circadian rythm related genes and Signaling pathways regulating pluripotency of stem cells. Affiliated tissues include skin, and related phenotypes are fatigue and fever

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Lujo virus, which has symptom bleeding.

Related Diseases for Lujo Hemorrhagic Fever

Diseases related to Lujo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 exanthem 29.8 GPT F3
2 lassa fever 10.4
3 viral hemorrhagic fever 10.2
4 fibrodysplasia ossificans progressiva 10.0 ID3 ID1
5 nutmeg liver 9.9 NPPB GPT
6 hydrops of gallbladder 9.9 NPPB GPT
7 apnea, obstructive sleep 9.8 NPPB GPT
8 emphysematous cholecystitis 9.8 GPT F3
9 hepatic infarction 9.8 GPT F3
10 ankylosing spondylitis 1 9.8 GPT F3
11 critical illness polyneuropathy 9.8 GPT F3
12 splenic infarction 9.8 GPT F3
13 rocky mountain spotted fever 9.8 GPT F3
14 analbuminemia 9.8 GPT F3
15 esophageal varix 9.8 GPT F3
16 anuria 9.8 GPT F3
17 compartment syndrome 9.7 GPT F3
18 cecal disease 9.7 GPT F3
19 aspiration pneumonia 9.7 GPT F3
20 multicentric castleman disease 9.7 ID1 F3
21 acute cor pulmonale 9.7 NPPB F3
22 crimean-congo hemorrhagic fever 9.7 GPT F3
23 acute pulmonary heart disease 9.7 NPPB F3
24 scrub typhus 9.7 GPT F3
25 splenic disease 9.7 GPT F3
26 cardiac tamponade 9.7 NPPB F3
27 tricuspid valve insufficiency 9.7 NPPB F3
28 tricuspid valve disease 9.7 NPPB F3
29 hepatic vascular disease 9.7 GPT F3
30 mitral valve stenosis 9.6 NPPB F3
31 vein disease 9.6 GPT F3
32 angina pectoris 9.6 NPPB F3
33 hepatic coma 9.6 GPT GOT1 F3
34 dengue hemorrhagic fever 9.5 GPT F3
35 intracranial hypertension 9.5 NPPB F3
36 hepatitis a 9.5 GPT F3
37 mitral valve disease 9.5 NPPB F3
38 rett syndrome 9.5 ID4 ID3 ID2 ID1
39 bilirubin metabolic disorder 9.5 GPT F3
40 pericardium disease 9.3 NPPB GPT F3
41 pulmonary artery disease 9.3 NPPB GPT F3
42 pericardial effusion 9.3 NPPB GPT F3
43 heart conduction disease 9.3 NPPB F3
44 lipoprotein quantitative trait locus 9.3 NPPB GPT F3
45 respiratory failure 9.2 NPPB GPT F3
46 peripheral artery disease 9.2 NPPB F3

Graphical network of the top 20 diseases related to Lujo Hemorrhagic Fever:



Diseases related to Lujo Hemorrhagic Fever

Symptoms & Phenotypes for Lujo Hemorrhagic Fever

Human phenotypes related to Lujo Hemorrhagic Fever:

58 31 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
4 gastrointestinal hemorrhage 58 31 frequent (33%) Frequent (79-30%) HP:0002239
5 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
6 recurrent pharyngitis 58 31 frequent (33%) Frequent (79-30%) HP:0100776
7 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
8 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
9 dyspnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002094
10 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
11 lethargy 58 31 occasional (7.5%) Occasional (29-5%) HP:0001254
12 acute hepatic failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0006554
13 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
14 cardiac arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0001695
15 seizure 31 occasional (7.5%) HP:0001250
16 seizures 58 Occasional (29-5%)

Symptoms:

12
  • bleeding

MGI Mouse Phenotypes related to Lujo Hemorrhagic Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 F3 ID1 ID2 ID3

Drugs & Therapeutics for Lujo Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Lujo Hemorrhagic Fever

Genetic Tests for Lujo Hemorrhagic Fever

Anatomical Context for Lujo Hemorrhagic Fever

MalaCards organs/tissues related to Lujo Hemorrhagic Fever:

40
Skin

Publications for Lujo Hemorrhagic Fever

Articles related to Lujo Hemorrhagic Fever:

# Title Authors PMID Year
1
[Lujo hemorrhagic fever]. 61
29733163 2017
2
Clinical features and patient management of Lujo hemorrhagic fever. 61
25393244 2014

Variations for Lujo Hemorrhagic Fever

Expression for Lujo Hemorrhagic Fever

Search GEO for disease gene expression data for Lujo Hemorrhagic Fever.

Pathways for Lujo Hemorrhagic Fever

GO Terms for Lujo Hemorrhagic Fever

Cellular components related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.23 NPPB LDHC ID4 ID3 ID2 ID1

Biological processes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.87 ID4 ID3 ID2 ID1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.85 ID4 ID3 ID2 ID1
3 negative regulation of transcription, DNA-templated GO:0045892 9.73 ID4 ID3 ID2 ID1
4 negative regulation of gene expression GO:0010629 9.71 ID3 ID2 ID1
5 heart development GO:0007507 9.67 ID3 ID2 ID1
6 rhythmic process GO:0048511 9.58 ID3 ID2 ID1
7 negative regulation of neuron differentiation GO:0045665 9.56 ID4 ID2
8 positive regulation of gene expression GO:0010628 9.55 ID4 ID3 ID2 ID1 F3
9 cellular amino acid biosynthetic process GO:0008652 9.52 GPT GOT1
10 biosynthetic process GO:0009058 9.51 GPT GOT1
11 negative regulation of DNA-binding transcription factor activity GO:0043433 9.5 ID3 ID2 ID1
12 metanephros development GO:0001656 9.48 ID3 ID2
13 negative regulation of DNA binding GO:0043392 9.46 ID2 ID1
14 negative regulation of osteoblast differentiation GO:0045668 9.43 ID3 ID2 ID1
15 negative regulation of oligodendrocyte differentiation GO:0048715 9.37 ID4 ID2
16 circadian rhythm GO:0007623 9.26 ID4 ID3 ID2 ID1
17 circadian regulation of gene expression GO:0032922 8.92 ID4 ID3 ID2 ID1

Molecular functions related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.62 ID4 ID3 ID2 ID1
2 transcription coactivator activity GO:0003713 9.43 ID3 ID2 ID1
3 pyridoxal phosphate binding GO:0030170 9.37 GPT GOT1
4 protein dimerization activity GO:0046983 9.26 ID4 ID3 ID2 ID1
5 transaminase activity GO:0008483 9.16 GPT GOT1
6 transcription regulator activity GO:0140110 8.92 ID4 ID3 ID2 ID1

Sources for Lujo Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....