Lujo Hemorrhagic Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Lujo Hemorrhagic Fever

MalaCards integrated aliases for Lujo Hemorrhagic Fever:

Name: Lujo Hemorrhagic Fever ¹² ⁵⁸ ³ ¹⁵

Zambian Hemorrhagic Fever ⁵⁸

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Arenaviral haemorrhagic fever

Other arenaviral haemorrhagic fevers

Orphanet: ⁵⁸

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:0050202

ICD10 via Orphanet ³³ A96.8

Orphanet ⁵⁸ ORPHA319213

Sources

Summaries for Lujo Hemorrhagic Fever

CDC : ³ Lujo hemorrhagic fever (LUHF) is caused by Lujo virus, a single-stranded virus of the Arenaviridae family. The limited clinical information about LUHF comes from a small, nosocomial cluster of hemorrhagic disease in September-October 2008 involving 5 patients in South Africa. The case fatality rate was 80% (4/5 cases).

MalaCards based summary : Lujo Hemorrhagic Fever, also known as zambian hemorrhagic fever, is related to lassa fever and exanthem, and has symptoms including bleeding An important gene associated with Lujo Hemorrhagic Fever is GOT1 (Glutamic-Oxaloacetic Transaminase 1), and among its related pathways/superpathways are Circadian rythm related genes and Signaling pathways regulating pluripotency of stem cells. Affiliated tissues include skin, and related phenotypes are fever and fatigue

Disease Ontology : ¹² A viral infectious disease that results in infection, has material basis in Lujo virus, which has symptom bleeding.

Sources

Related Diseases for Lujo Hemorrhagic Fever

Diseases related to Lujo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)

#	Related Disease	Score	Top Affiliating Genes
1	lassa fever	10.4
2	exanthem	10.2
3	viral hemorrhagic fever	10.2
4	multicentric castleman disease	9.8	ID1 F3
5	fibrodysplasia ossificans progressiva	9.8	ID3 ID1
6	acute cor pulmonale	9.7	NPPB F3
7	acute pulmonary heart disease	9.7	NPPB F3
8	cardiac tamponade	9.7	NPPB F3
9	tricuspid valve insufficiency	9.7	NPPB F3
10	tricuspid valve disease	9.7	NPPB F3
11	mitral valve stenosis	9.7	NPPB F3
12	pericardium disease	9.6	NPPB F3
13	angina pectoris	9.6	NPPB F3
14	pulmonary artery disease	9.6	NPPB F3
15	pericardial effusion	9.6	NPPB F3
16	intracranial hypertension	9.6	NPPB F3
17	heart conduction disease	9.5	NPPB F3
18	peripheral artery disease	9.5	NPPB F3
19	heart valve disease	9.4	NPPB F3
20	pulmonary embolism	9.2	NPPB F3
21	rett syndrome	9.2	ID4 ID3 ID2 ID1

Graphical network of the top 20 diseases related to Lujo Hemorrhagic Fever:

Sources

Symptoms & Phenotypes for Lujo Hemorrhagic Fever

Human phenotypes related to Lujo Hemorrhagic Fever:

⁵⁸ ³¹ (show all 15)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	fever ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001945
2	fatigue ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0012378
3	nausea and vomiting ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002017
4	gastrointestinal hemorrhage ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002239
5	myalgia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0003326
6	headache ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002315
7	diarrhea ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002014
8	recurrent pharyngitis ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0100776
9	seizures ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001250
10	dyspnea ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002094
11	skin rash ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000988
12	coma ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001259
13	acute hepatic failure ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0006554
14	lethargy ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001254
15	cardiac arrest ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001695

Symptoms:

¹²

• bleeding

MGI Mouse Phenotypes related to Lujo Hemorrhagic Fever:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.35	ID1 ID2 ID3 ID4 LDHC
2	neoplasm	MP:0002006	8.92	F3 ID1 ID2 ID3

Sources

Drugs & Therapeutics for Lujo Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Lujo Hemorrhagic Fever

Sources

Genetic Tests for Lujo Hemorrhagic Fever

Sources

Anatomical Context for Lujo Hemorrhagic Fever

MalaCards organs/tissues related to Lujo Hemorrhagic Fever:

⁴⁰

Skin

Sources

Publications for Lujo Hemorrhagic Fever

Articles related to Lujo Hemorrhagic Fever:

#	Title	Authors	PMID	Year
1	[Lujo hemorrhagic fever]. ⁶¹	Sizikova TE...Borisevich SV	29733163	2017
2	Clinical features and patient management of Lujo hemorrhagic fever. ⁶¹	Sewlall NH...Bausch D	25393244	2014

Sources

Genes for Lujo Hemorrhagic Fever

Genes related to Lujo Hemorrhagic Fever (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GOT1	Glutamic-Oxaloacetic Transaminase 1	Protein Coding	5.64	DISEASES inferred ¹⁵
2	LDHC	Lactate Dehydrogenase C	Protein Coding	5.44	DISEASES inferred ¹⁵
3	ID4	Inhibitor Of DNA Binding 4, HLH Protein	Protein Coding	5.03	DISEASES inferred ¹⁵
4	ID3	Inhibitor Of DNA Binding 3, HLH Protein	Protein Coding	4.95	DISEASES inferred ¹⁵
5	ID2	Inhibitor Of DNA Binding 2	Protein Coding	4.81	DISEASES inferred ¹⁵
6	ID1	Inhibitor Of DNA Binding 1, HLH Protein	Protein Coding	4.68	DISEASES inferred ¹⁵
7	NPPB	Natriuretic Peptide B	Protein Coding	4.24	DISEASES inferred ¹⁵
8	F3	Coagulation Factor III, Tissue Factor	Protein Coding	3.57	DISEASES inferred ¹⁵

Sources

Variations for Lujo Hemorrhagic Fever

Sources

Expression for Lujo Hemorrhagic Fever

Search GEO for disease gene expression data for Lujo Hemorrhagic Fever.

Sources

Pathways for Lujo Hemorrhagic Fever

Pathways related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Circadian rythm related genes ¹	11.81	ID4 ID3 ID2
2	Signaling pathways regulating pluripotency of stem cells ³⁶	11.6	ID4 ID3 ID2 ID1
3	TGF-beta signaling pathway (KEGG) ³⁶	10.9	ID4 ID3 ID2 ID1
4	ID signaling pathway ¹	10.34	ID3 ID2 ID1
5	miR-517 relationship with ARCN1 and USP1 ¹	9.96	ID2 ID1

Sources

GO Terms for Lujo Hemorrhagic Fever

Biological processes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription by RNA polymerase II	GO:0000122	9.84	ID4 ID3 ID2 ID1
2	negative regulation of transcription, DNA-templated	GO:0045892	9.78	ID4 ID3 ID2 ID1
3	positive regulation of gene expression	GO:0010628	9.72	ID4 ID2 ID1
4	negative regulation of gene expression	GO:0010629	9.7	ID3 ID2 ID1
5	heart development	GO:0007507	9.67	ID3 ID2 ID1
6	rhythmic process	GO:0048511	9.63	ID3 ID2 ID1
7	neuron differentiation	GO:0030182	9.62	ID4 ID3 ID2 ID1
8	negative regulation of DNA-binding transcription factor activity	GO:0043433	9.58	ID3 ID2 ID1
9	regulation of cell cycle	GO:0051726	9.56	ID4 ID3 ID2 ID1
10	negative regulation of osteoblast differentiation	GO:0045668	9.54	ID3 ID2 ID1
11	metanephros development	GO:0001656	9.51	ID3 ID2
12	circadian rhythm	GO:0007623	9.46	ID4 ID3 ID2 ID1
13	negative regulation of oligodendrocyte differentiation	GO:0048715	9.43	ID4 ID2
14	negative regulation of neuron differentiation	GO:0045665	9.26	ID4 ID3 ID2 ID1
15	negative regulation of DNA binding	GO:0043392	8.92	ID4 ID3 ID2 ID1

Molecular functions related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	9.62	ID4 ID3 ID2 ID1
2	DNA-binding transcription factor activity	GO:0003700	9.56	ID4 ID3 ID2 ID1
3	transcription factor binding	GO:0008134	9.46	ID4 ID3 ID2 ID1
4	protein dimerization activity	GO:0046983	9.26	ID4 ID3 ID2 ID1
5	RNA polymerase II transcription factor binding	GO:0001085	8.92	ID4 ID3 ID2 ID1

Sources

Sources for Lujo Hemorrhagic Fever

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia