MCID: LJH001
MIFTS: 31

Lujo Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lujo Hemorrhagic Fever

Summaries for Lujo Hemorrhagic Fever

CDC : 3 Lujo hemorrhagic fever (LUHF) is caused by Lujo virus, a single-stranded virus of the Arenaviridae family. The limited clinical information about LUHF comes from a small, nosocomial cluster of hemorrhagic disease in September-October 2008 involving 5 patients in South Africa. The case fatality rate was 80% (4/5 cases).

MalaCards based summary : Lujo Hemorrhagic Fever, also known as zambian hemorrhagic fever, is related to lassa fever and exanthem, and has symptoms including bleeding An important gene associated with Lujo Hemorrhagic Fever is GOT1 (Glutamic-Oxaloacetic Transaminase 1), and among its related pathways/superpathways are Circadian rythm related genes and Signaling pathways regulating pluripotency of stem cells. Affiliated tissues include skin, and related phenotypes are fever and fatigue

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Lujo virus, which has symptom bleeding.

Related Diseases for Lujo Hemorrhagic Fever

Graphical network of the top 20 diseases related to Lujo Hemorrhagic Fever:



Diseases related to Lujo Hemorrhagic Fever

Symptoms & Phenotypes for Lujo Hemorrhagic Fever

Human phenotypes related to Lujo Hemorrhagic Fever:

58 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
3 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
4 gastrointestinal hemorrhage 58 31 frequent (33%) Frequent (79-30%) HP:0002239
5 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
6 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
7 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
8 recurrent pharyngitis 58 31 frequent (33%) Frequent (79-30%) HP:0100776
9 seizures 58 31 occasional (7.5%) Occasional (29-5%) HP:0001250
10 dyspnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002094
11 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
12 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
13 acute hepatic failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0006554
14 lethargy 58 31 occasional (7.5%) Occasional (29-5%) HP:0001254
15 cardiac arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0001695

Symptoms:

12
  • bleeding

MGI Mouse Phenotypes related to Lujo Hemorrhagic Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.35 ID1 ID2 ID3 ID4 LDHC
2 neoplasm MP:0002006 8.92 F3 ID1 ID2 ID3

Drugs & Therapeutics for Lujo Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Lujo Hemorrhagic Fever

Genetic Tests for Lujo Hemorrhagic Fever

Anatomical Context for Lujo Hemorrhagic Fever

MalaCards organs/tissues related to Lujo Hemorrhagic Fever:

40
Skin

Publications for Lujo Hemorrhagic Fever

Articles related to Lujo Hemorrhagic Fever:

# Title Authors PMID Year
1
[Lujo hemorrhagic fever]. 61
29733163 2017
2
Clinical features and patient management of Lujo hemorrhagic fever. 61
25393244 2014

Variations for Lujo Hemorrhagic Fever

Expression for Lujo Hemorrhagic Fever

Search GEO for disease gene expression data for Lujo Hemorrhagic Fever.

Pathways for Lujo Hemorrhagic Fever

Pathways related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2 11.6 ID4 ID3 ID2 ID1
3 10.9 ID4 ID3 ID2 ID1
4 10.34 ID3 ID2 ID1
5 9.96 ID2 ID1

GO Terms for Lujo Hemorrhagic Fever

Biological processes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.84 ID4 ID3 ID2 ID1
2 negative regulation of transcription, DNA-templated GO:0045892 9.78 ID4 ID3 ID2 ID1
3 positive regulation of gene expression GO:0010628 9.72 ID4 ID2 ID1
4 negative regulation of gene expression GO:0010629 9.7 ID3 ID2 ID1
5 heart development GO:0007507 9.67 ID3 ID2 ID1
6 rhythmic process GO:0048511 9.63 ID3 ID2 ID1
7 neuron differentiation GO:0030182 9.62 ID4 ID3 ID2 ID1
8 negative regulation of DNA-binding transcription factor activity GO:0043433 9.58 ID3 ID2 ID1
9 regulation of cell cycle GO:0051726 9.56 ID4 ID3 ID2 ID1
10 negative regulation of osteoblast differentiation GO:0045668 9.54 ID3 ID2 ID1
11 metanephros development GO:0001656 9.51 ID3 ID2
12 circadian rhythm GO:0007623 9.46 ID4 ID3 ID2 ID1
13 negative regulation of oligodendrocyte differentiation GO:0048715 9.43 ID4 ID2
14 negative regulation of neuron differentiation GO:0045665 9.26 ID4 ID3 ID2 ID1
15 negative regulation of DNA binding GO:0043392 8.92 ID4 ID3 ID2 ID1

Molecular functions related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.62 ID4 ID3 ID2 ID1
2 DNA-binding transcription factor activity GO:0003700 9.56 ID4 ID3 ID2 ID1
3 transcription factor binding GO:0008134 9.46 ID4 ID3 ID2 ID1
4 protein dimerization activity GO:0046983 9.26 ID4 ID3 ID2 ID1
5 RNA polymerase II transcription factor binding GO:0001085 8.92 ID4 ID3 ID2 ID1

Sources for Lujo Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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