Lujo Hemorrhagic Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lujo Hemorrhagic Fever

MalaCards integrated aliases for Lujo Hemorrhagic Fever:

Name: Lujo Hemorrhagic Fever ¹² ⁵⁸ ³ ¹⁵

Zambian Hemorrhagic Fever ⁵⁸

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Arenaviral haemorrhagic fever

Other arenaviral haemorrhagic fevers

Orphanet: ⁵⁸

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:0050202

ICD10 via Orphanet ³³ A96.8

Orphanet ⁵⁸ ORPHA319213

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Summaries for Lujo Hemorrhagic Fever

CDC : ³ Lujo hemorrhagic fever (LUHF) is caused by Lujo virus, a single-stranded virus of the Arenaviridae family. The limited clinical information about LUHF comes from a small, nosocomial cluster of hemorrhagic disease in September-October 2008 involving 5 patients in South Africa. The case fatality rate was 80% (4/5 cases).

MalaCards based summary : Lujo Hemorrhagic Fever, also known as zambian hemorrhagic fever, is related to exanthem and lassa fever, and has symptoms including bleeding An important gene associated with Lujo Hemorrhagic Fever is GOT1 (Glutamic-Oxaloacetic Transaminase 1), and among its related pathways/superpathways are Circadian rythm related genes and Signaling pathways regulating pluripotency of stem cells. Affiliated tissues include skin, and related phenotypes are fatigue and fever

Disease Ontology : ¹² A viral infectious disease that results in infection, has material basis in Lujo virus, which has symptom bleeding.

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Related Diseases for Lujo Hemorrhagic Fever

Diseases related to Lujo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)

#	Related Disease	Score	Top Affiliating Genes
1	exanthem	29.8	GPT F3
2	lassa fever	10.4
3	viral hemorrhagic fever	10.2
4	fibrodysplasia ossificans progressiva	10.0	ID3 ID1
5	nutmeg liver	9.9	NPPB GPT
6	hydrops of gallbladder	9.9	NPPB GPT
7	apnea, obstructive sleep	9.8	NPPB GPT
8	emphysematous cholecystitis	9.8	GPT F3
9	hepatic infarction	9.8	GPT F3
10	ankylosing spondylitis 1	9.8	GPT F3
11	critical illness polyneuropathy	9.8	GPT F3
12	splenic infarction	9.8	GPT F3
13	rocky mountain spotted fever	9.8	GPT F3
14	analbuminemia	9.8	GPT F3
15	esophageal varix	9.8	GPT F3
16	anuria	9.8	GPT F3
17	compartment syndrome	9.7	GPT F3
18	cecal disease	9.7	GPT F3
19	aspiration pneumonia	9.7	GPT F3
20	multicentric castleman disease	9.7	ID1 F3
21	acute cor pulmonale	9.7	NPPB F3
22	crimean-congo hemorrhagic fever	9.7	GPT F3
23	acute pulmonary heart disease	9.7	NPPB F3
24	scrub typhus	9.7	GPT F3
25	splenic disease	9.7	GPT F3
26	cardiac tamponade	9.7	NPPB F3
27	tricuspid valve insufficiency	9.7	NPPB F3
28	tricuspid valve disease	9.7	NPPB F3
29	hepatic vascular disease	9.7	GPT F3
30	mitral valve stenosis	9.6	NPPB F3
31	vein disease	9.6	GPT F3
32	angina pectoris	9.6	NPPB F3
33	hepatic coma	9.6	GPT GOT1 F3
34	dengue hemorrhagic fever	9.5	GPT F3
35	intracranial hypertension	9.5	NPPB F3
36	hepatitis a	9.5	GPT F3
37	mitral valve disease	9.5	NPPB F3
38	rett syndrome	9.5	ID4 ID3 ID2 ID1
39	bilirubin metabolic disorder	9.5	GPT F3
40	pericardium disease	9.3	NPPB GPT F3
41	pulmonary artery disease	9.3	NPPB GPT F3
42	pericardial effusion	9.3	NPPB GPT F3
43	heart conduction disease	9.3	NPPB F3
44	lipoprotein quantitative trait locus	9.3	NPPB GPT F3
45	respiratory failure	9.2	NPPB GPT F3
46	peripheral artery disease	9.2	NPPB F3

Graphical network of the top 20 diseases related to Lujo Hemorrhagic Fever:

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Symptoms & Phenotypes for Lujo Hemorrhagic Fever

Human phenotypes related to Lujo Hemorrhagic Fever:

⁵⁸ ³¹ (show all 16)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	fatigue ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0012378
2	fever ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001945
3	nausea and vomiting ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002017
4	gastrointestinal hemorrhage ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002239
5	myalgia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0003326
6	recurrent pharyngitis ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0100776
7	headache ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002315
8	diarrhea ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002014
9	dyspnea ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002094
10	skin rash ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000988
11	lethargy ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001254
12	acute hepatic failure ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0006554
13	coma ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001259
14	cardiac arrest ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001695
15	seizure ³¹	occasional (7.5%)		HP:0001250
16	seizures ⁵⁸		Occasional (29-5%)

Symptoms:

¹²

• bleeding

MGI Mouse Phenotypes related to Lujo Hemorrhagic Fever:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	8.92	F3 ID1 ID2 ID3

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Drugs & Therapeutics for Lujo Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Lujo Hemorrhagic Fever

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Genetic Tests for Lujo Hemorrhagic Fever

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Anatomical Context for Lujo Hemorrhagic Fever

MalaCards organs/tissues related to Lujo Hemorrhagic Fever:

⁴⁰

Skin

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Publications for Lujo Hemorrhagic Fever

Articles related to Lujo Hemorrhagic Fever:

#	Title	Authors	PMID	Year
1	[Lujo hemorrhagic fever]. ⁶¹	Sizikova TE...Borisevich SV	29733163	2017
2	Clinical features and patient management of Lujo hemorrhagic fever. ⁶¹	Sewlall NH...Bausch D	25393244	2014

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Genes for Lujo Hemorrhagic Fever

Genes related to Lujo Hemorrhagic Fever (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GOT1	Glutamic-Oxaloacetic Transaminase 1	Protein Coding	5.6	DISEASES inferred ¹⁵
2	LDHC	Lactate Dehydrogenase C	Protein Coding	5.44	DISEASES inferred ¹⁵
3	ID4	Inhibitor Of DNA Binding 4, HLH Protein	Protein Coding	5.01	DISEASES inferred ¹⁵
4	ID3	Inhibitor Of DNA Binding 3, HLH Protein	Protein Coding	4.95	DISEASES inferred ¹⁵
5	ID2	Inhibitor Of DNA Binding 2	Protein Coding	4.81	DISEASES inferred ¹⁵
6	ID1	Inhibitor Of DNA Binding 1, HLH Protein	Protein Coding	4.7	DISEASES inferred ¹⁵
7	NPPB	Natriuretic Peptide B	Protein Coding	4.19	DISEASES inferred ¹⁵
8	F3	Coagulation Factor III, Tissue Factor	Protein Coding	3.56	DISEASES inferred ¹⁵
9	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	3.22	DISEASES inferred ¹⁵

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Variations for Lujo Hemorrhagic Fever

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Expression for Lujo Hemorrhagic Fever

Search GEO for disease gene expression data for Lujo Hemorrhagic Fever.

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Pathways for Lujo Hemorrhagic Fever

Pathways related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Circadian rythm related genes ¹	11.9	ID4 ID3 ID2
2	Signaling pathways regulating pluripotency of stem cells ³⁶	11.61	ID4 ID3 ID2 ID1
3	TGF-beta signaling pathway (KEGG) ³⁶	11.23	ID4 ID3 ID2 ID1
4	Amino acid synthesis and interconversion (transamination) ⁶⁵ Show member pathways asparagine biosynthesis ¹ L-cysteine degradation II ¹ Serine biosynthesis ⁶⁵	11.08	GPT GOT1
5	Alanine, aspartate and glutamate metabolism ³⁶	10.99	GPT GOT1
6	Arginine biosynthesis ³⁶ Show member pathways citrulline-nitric oxide cycle ¹	10.78	GPT GOT1
7	Alanine and aspartate metabolism ¹ Show member pathways alanine biosynthesis/degradation ¹	10.44	GPT GOT1
8	ID signaling pathway ¹	10	ID3 ID2 ID1
9	miR-517 relationship with ARCN1 and USP1 ¹	9.96	ID2 ID1

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GO Terms for Lujo Hemorrhagic Fever

Cellular components related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	9.23	NPPB LDHC ID4 ID3 ID2 ID1

Biological processes related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell differentiation	GO:0030154	9.87	ID4 ID3 ID2 ID1
2	negative regulation of transcription by RNA polymerase II	GO:0000122	9.85	ID4 ID3 ID2 ID1
3	negative regulation of transcription, DNA-templated	GO:0045892	9.73	ID4 ID3 ID2 ID1
4	negative regulation of gene expression	GO:0010629	9.71	ID3 ID2 ID1
5	heart development	GO:0007507	9.67	ID3 ID2 ID1
6	rhythmic process	GO:0048511	9.58	ID3 ID2 ID1
7	negative regulation of neuron differentiation	GO:0045665	9.56	ID4 ID2
8	positive regulation of gene expression	GO:0010628	9.55	ID4 ID3 ID2 ID1 F3
9	cellular amino acid biosynthetic process	GO:0008652	9.52	GPT GOT1
10	biosynthetic process	GO:0009058	9.51	GPT GOT1
11	negative regulation of DNA-binding transcription factor activity	GO:0043433	9.5	ID3 ID2 ID1
12	metanephros development	GO:0001656	9.48	ID3 ID2
13	negative regulation of DNA binding	GO:0043392	9.46	ID2 ID1
14	negative regulation of osteoblast differentiation	GO:0045668	9.43	ID3 ID2 ID1
15	negative regulation of oligodendrocyte differentiation	GO:0048715	9.37	ID4 ID2
16	circadian rhythm	GO:0007623	9.26	ID4 ID3 ID2 ID1
17	circadian regulation of gene expression	GO:0032922	8.92	ID4 ID3 ID2 ID1

Molecular functions related to Lujo Hemorrhagic Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	9.62	ID4 ID3 ID2 ID1
2	transcription coactivator activity	GO:0003713	9.43	ID3 ID2 ID1
3	pyridoxal phosphate binding	GO:0030170	9.37	GPT GOT1
4	protein dimerization activity	GO:0046983	9.26	ID4 ID3 ID2 ID1
5	transaminase activity	GO:0008483	9.16	GPT GOT1
6	transcription regulator activity	GO:0140110	8.92	ID4 ID3 ID2 ID1

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Sources for Lujo Hemorrhagic Fever

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