MCID: LMB003
MIFTS: 23

Lumbosacral Lipoma

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Lumbosacral Lipoma

MalaCards integrated aliases for Lumbosacral Lipoma:

Name: Lumbosacral Lipoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7017
NCIt 50 C6500
UMLS 73 C1334438

Summaries for Lumbosacral Lipoma

MalaCards based summary : Lumbosacral Lipoma is related to oeis complex and lipomyelomeningocele. An important gene associated with Lumbosacral Lipoma is MNX1 (Motor Neuron And Pancreas Homeobox 1), and among its related pathways/superpathways are ADP signalling through P2Y purinoceptor 1 and Sphingolipid signaling pathway. Affiliated tissues include bone, testes and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Lumbosacral Lipoma

Diseases related to Lumbosacral Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 oeis complex 9.8
2 lipomyelomeningocele 9.8
3 myelomeningocele 9.8
4 tethered spinal cord syndrome 9.8
5 dermoid cyst 9.8
6 conjunctivitis 9.8
7 tethered cord syndrome 9.8

Graphical network of the top 20 diseases related to Lumbosacral Lipoma:



Diseases related to Lumbosacral Lipoma

Symptoms & Phenotypes for Lumbosacral Lipoma

GenomeRNAi Phenotypes related to Lumbosacral Lipoma according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.8 MAPK14
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.8 MAPK14
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.8 F2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.8 F2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.8 F2 MAPK14
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.8 F2 MAPK14
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.8 F2 MAPK14
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.8 F2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.8 MAPK14
10 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.8 F2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.8 MAPK14
12 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.8 MAPK14
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.26 MNX1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.26 F2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.26 MNX1 F2

MGI Mouse Phenotypes related to Lumbosacral Lipoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.46 MNX1 SPTLC1 F2 MAPK14
2 nervous system MP:0003631 9.26 MNX1 SPTLC1 F2 MAPK14
3 respiratory system MP:0005388 8.8 MAPK14 MNX1 F2

Drugs & Therapeutics for Lumbosacral Lipoma

Search Clinical Trials , NIH Clinical Center for Lumbosacral Lipoma

Genetic Tests for Lumbosacral Lipoma

Anatomical Context for Lumbosacral Lipoma

MalaCards organs/tissues related to Lumbosacral Lipoma:

41
Bone, Testes, Spinal Cord

Publications for Lumbosacral Lipoma

Articles related to Lumbosacral Lipoma:

(show all 25)
# Title Authors Year
1
Spinal column shortening for tethered cord syndrome associated with myelomeningocele, lumbosacral lipoma, and lipomyelomeningocele in children and young adults. ( 28362188 )
2017
2
Conservative and surgical treatment of pediatric asymptomatic lumbosacral lipoma: a meta-analysis. ( 27796602 )
2016
3
The natural history and management of patients with congenital deficits associated with lumbosacral lipomas. ( 26753902 )
2016
4
Double lumbosacral lipomas of the dorsal and filar types associated with OEIS complex: case report. ( 19855150 )
2009
5
Coexistence of a human tail and congenital dermal sinus associated with lumbosacral lipoma. ( 18690460 )
2009
6
Unusual MR presentation of occult spinal dysraphism with lumbosacral lipoma and dermoid cyst. ( 16937140 )
2007
7
Tight filum terminale syndrome in children: analysis based on positioning of the conus and absence or presence of lumbosacral lipoma. ( 17551741 )
2007
8
Dynamic morphological changes in lumbosacral lipoma during the first months of life revealed by constructive interference in steady-state (CISS) MR imaging. ( 17187271 )
2007
9
Prognostic factors affecting urologic outcome after untethering surgery for lumbosacral lipoma. ( 16586137 )
2006
10
Usefulness of constructive interference in steady-state magnetic resonance imaging in the presurgical examination for lumbosacral lipoma. ( 16383253 )
2005
11
Pathogenesis of lumbosacral lipoma: a test of the &amp;quot;premature dysjunction&amp;quot; theory. ( 11359100 )
2001
12
Results after surgery for lumbosacral lipoma: the significance of early and late worsening. ( 10502000 )
1999
13
Spontaneous shrinkage of lumbosacral lipoma in conjunction with a general decrease in body fat: case report. ( 9657202 )
1998
14
MRI study of lumbosacral lipoma in children. ( 2755744 )
1989
15
Ectopic immature renal tissue in a lumbosacral lipoma: pathologic and radiologic findings. ( 2635297 )
1989
16
Intraspinal lumbosacral lipoma: review of literature and report of three cases. ( 3056377 )
1988
17
Late neurological dysfunction in adult lumbosacral lipoma. ( 3625290 )
1987
18
Lumbosacral lipoma causing tethering of the conus: case report. ( 3570724 )
1987
19
Magnetic resonance imaging: lumbosacral lipoma. ( 3629457 )
1987
20
Congenital lumbosacral lipoma causing primary enuresis in an adult. ( 3756729 )
1986
21
[Tethered conus syndrome or fixed spinal cord syndrome. Lumbosacral lipomas]. ( 3890073 )
1985
22
Late neurological dysfunction in adult lumbosacral lipoma with tethered cord. ( 6390243 )
1984
23
Lumbosacral lipoma investigated by conventional radiography, ultrasound and direct coronal mode CT-scanning. ( 7187291 )
1982
24
Lumbosacral lipoma with acute deterioration during infancy. ( 7402775 )
1980
25
Lumbosacral lipoma in the adult: case report. ( 4880819 )
1968

Variations for Lumbosacral Lipoma

Expression for Lumbosacral Lipoma

Search GEO for disease gene expression data for Lumbosacral Lipoma.

Pathways for Lumbosacral Lipoma

Pathways related to Lumbosacral Lipoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.16 F2 MAPK14
2 10.7 MAPK14 SPTLC1

GO Terms for Lumbosacral Lipoma

Biological processes related to Lumbosacral Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.16 F2 MAPK14
2 regulation of gene expression GO:0010468 8.96 F2 MAPK14
3 positive regulation of reactive oxygen species metabolic process GO:2000379 8.62 F2 MAPK14

Sources for Lumbosacral Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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