Lumbosacral Plexus Lesion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lumbosacral Plexus Lesion

MalaCards integrated aliases for Lumbosacral Plexus Lesion:

Name: Lumbosacral Plexus Lesion ¹² ¹⁵ ⁷¹

Lumbosacral Plexus Lesions ¹²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Injury, poisoning and certain other consequences of external causes

Injuries to the abdomen, lower back, lumbar spine and pelvis

Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level

Injury of lumbosacral plexus

External Ids:

Disease Ontology ¹² DOID:13913

ICD9CM ³⁴ 353.1

SNOMED-CT ⁶⁷ 4062006

ICD10 ³² S34.4

UMLS ⁷¹ C0154735

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Summaries for Lumbosacral Plexus Lesion

MalaCards based summary : Lumbosacral Plexus Lesion, also known as lumbosacral plexus lesions, is related to autoimmune optic neuritis and alzheimer disease 17. An important gene associated with Lumbosacral Plexus Lesion is UNG (Uracil DNA Glycosylase), and among its related pathways/superpathways are Development HGF signaling pathway and MAPK signaling pathway. Affiliated tissues include spinal cord, and related phenotypes are behavior/neurological and nervous system

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Related Diseases for Lumbosacral Plexus Lesion

Diseases related to Lumbosacral Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)

#	Related Disease	Score	Top Affiliating Genes
1	autoimmune optic neuritis	10.3	CNTF AIF1
2	alzheimer disease 17	10.1	RBFOX3 AIF1
3	middle ear carcinoma	10.1	SYP AIF1
4	cerebellar liponeurocytoma	10.1	SYP RBFOX3
5	clear cell ependymoma	10.1	SYP RBFOX3
6	gangliocytoma	10.1	SYP RBFOX3
7	cerebral artery occlusion	10.0	CNTF BDNF
8	carotid artery occlusion	10.0	RBFOX3 AIF1
9	cerebral ventricle cancer	10.0	SYP RBFOX3
10	optic nerve astrocytoma	10.0	SYP NF1
11	cerebrum cancer	10.0	SYP RBFOX3
12	punctate epithelial keratoconjunctivitis	10.0	NGF CNTF
13	amyotrophy, hereditary neuralgic	10.0
14	amyotrophic neuralgia	10.0
15	neurilemmoma	10.0
16	plexopathy	10.0
17	extra-adrenal pheochromocytoma	10.0	SYP NF1
18	gliofibroma	9.9	SYP NF1
19	supratentorial cancer	9.9	SYP RBFOX3
20	cerebellum cancer	9.9	SYP NF1
21	hypochondriasis	9.9	NTF4 NTF3 BDNF
22	cauda equina neoplasm	9.9	SYP RPL24 RBFOX3
23	cranial nerve neoplasm	9.9	SYP NF1
24	adrenal medulla cancer	9.9	SYP NF1
25	spinal cancer	9.9	SYP NF1
26	polyradiculopathy	9.9	RPL24 NGF
27	obstructive hydrocephalus	9.9	SYP NF1
28	optic nerve disease	9.9	CNTF BDNF AIF1
29	autonomic nervous system benign neoplasm	9.9	SYP NF1
30	peripheral nervous system benign neoplasm	9.9	SYP NF1
31	subleukemic leukemia	9.8	SYP RBFOX3 AIF1
32	adrenal gland pheochromocytoma	9.8	NGF BDNF
33	occlusion precerebral artery	9.8	RBFOX3 BDNF AIF1
34	encephalomalacia	9.8	RBFOX3 BDNF AIF1
35	diabetic autonomic neuropathy	9.8	NTF3 NGF
36	diabetic encephalopathy	9.8	NGF BDNF
37	askin's tumor	9.8	SYP NGF
38	ependymoblastoma	9.8	SYP NGF
39	chronic cystitis	9.8	NGF BDNF
40	neuropathy, hereditary sensory and autonomic, type v	9.7	NGF BDNF
41	cannabis abuse	9.7	NGF BDNF
42	exophthalmos	9.7	SYP NF1
43	mononeuritis of lower limb	9.7	NTF4 NTF3 NGF
44	lesion of sciatic nerve	9.7	NTF4 NTF3 NGF
45	cataract 38	9.7	NTF4 NTF3 NGF
46	microvascular complications of diabetes 1	9.7	NTF3 NGF CNTF
47	diabetic neuropathy	9.7	NTF3 NGF CNTF
48	diabetic polyneuropathy	9.7	NTF3 NGF
49	spinal cord oligodendroglioma	9.7	SYP RBFOX3 NF1
50	central nervous system benign neoplasm	9.6	SYP RBFOX3 NF1

Comorbidity relations with Lumbosacral Plexus Lesion via Phenotypic Disease Network (PDN):

Acute Cystitis

Hypertension, Essential

Graphical network of the top 20 diseases related to Lumbosacral Plexus Lesion:

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Symptoms & Phenotypes for Lumbosacral Plexus Lesion

MGI Mouse Phenotypes related to Lumbosacral Plexus Lesion:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.56	BDNF CNTF NF1 NGF NTF3 NTF4
2	nervous system	MP:0003631	9.32	AIF1 BDNF CNTF NF1 NGF NTF3

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Drugs & Therapeutics for Lumbosacral Plexus Lesion

Search Clinical Trials , NIH Clinical Center for Lumbosacral Plexus Lesion

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Genetic Tests for Lumbosacral Plexus Lesion

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Anatomical Context for Lumbosacral Plexus Lesion

MalaCards organs/tissues related to Lumbosacral Plexus Lesion:

⁴⁰

Spinal Cord

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Publications for Lumbosacral Plexus Lesion

Articles related to Lumbosacral Plexus Lesion:

#	Title	Authors	PMID	Year
1	Diagnosis of brachial and lumbosacral plexus lesions. ⁶¹	van Alfen N...Malessy MJ	23931788	2013
2	Lumbosacral plexus lesions. ⁶¹	Stevanato G...Squintani G	17985537	2007
3	Multifocal acquired demyelinating sensory and motor neuropathy presenting as a peripheral nerve tumor. ⁶¹	Allen DC...Mills KR	16609974	2006
4	Lumbosacral plexus lesions: correlation of clinical signs and computed tomography. ⁶¹	Vock P...Mumenthaler M	3351532	1988
5	Late irradiation-induced lesions of the lumbosacral plexus. ⁶¹	Aho K...Sainio K	6306507	1983

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Genes for Lumbosacral Plexus Lesion

Genes related to Lumbosacral Plexus Lesion (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	UNG	Uracil DNA Glycosylase	Protein Coding	5.67	DISEASES inferred ¹⁵
2	RPL24	Ribosomal Protein L24	Protein Coding	5.29	DISEASES inferred ¹⁵
3	RPS13	Ribosomal Protein S13	Protein Coding	4.92	DISEASES inferred ¹⁵
4	CNTF	Ciliary Neurotrophic Factor	Protein Coding	4.48	DISEASES inferred ¹⁵
5	NTF4	Neurotrophin 4	Protein Coding	4.32	DISEASES inferred ¹⁵
6	NTF3	Neurotrophin 3	Protein Coding	4.21	DISEASES inferred ¹⁵
7	AIF1	Allograft Inflammatory Factor 1	Protein Coding	4.1	DISEASES inferred ¹⁵
8	RBFOX3	RNA Binding Fox-1 Homolog 3	Protein Coding	4.05	DISEASES inferred ¹⁵
9	SYP	Synaptophysin	Protein Coding	3.7	DISEASES inferred ¹⁵
10	NF1	Neurofibromin 1	Protein Coding	3.65	DISEASES inferred ¹⁵
11	NGF	Nerve Growth Factor	Protein Coding	3.56	DISEASES inferred ¹⁵
12	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	3.38	DISEASES inferred ¹⁵

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Variations for Lumbosacral Plexus Lesion

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Expression for Lumbosacral Plexus Lesion

Search GEO for disease gene expression data for Lumbosacral Plexus Lesion.

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Pathways for Lumbosacral Plexus Lesion

Pathways related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

(show all 15)

#	Super pathways	Score	Top Affiliating Genes
1	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.44	NTF4 NTF3 NGF BDNF
2	MAPK signaling pathway ¹ ³⁶	12.43	NTF4 NTF3 NGF NF1 BDNF
3	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.42	NTF4 NTF3 NGF BDNF
4	Neuroscience ⁴	12.31	SYP RBFOX3 NGF NF1
5	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.3	NTF4 NTF3 NGF NF1 BDNF
6	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²² Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²² Cell adhesion Tight junctions ²² Cytoskeleton remodeling Integrin outside-in signaling ²² Development MAG-dependent inhibition of neurite outgrowth ²²	12.26	NTF4 NTF3 NGF BDNF
7	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.13	NTF4 NTF3 NGF BDNF
8	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	11.97	NTF4 NTF3 NGF BDNF
9	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	11.86	NTF3 NGF BDNF
10	G-protein signaling_RhoA regulation pathway ²²	11.42	NTF4 NTF3 NGF BDNF
11	p75(NTR)-mediated signaling ¹ Show member pathways Ceramide signalling ⁶⁵ NFG and proNGF binds to p75NTR ⁶⁵	11.28	NTF4 NTF3 NGF BDNF
12	Microglia Activation During Neuroinflammation: Steady-State Microglia ⁶⁴	11.15	NTF3 NGF BDNF
13	Neurotrophic factor-mediated Trk receptor signaling ¹ Show member pathways Signalling to STAT3 ⁶⁵ TRKA activation by NGF ⁶⁵	11.04	NTF4 NTF3 NGF BDNF
14	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11	SYP NTF4 NTF3 NGF CNTF BDNF
15	G-protein signaling_Rap2B regulation pathway ²²	10.75	NTF4 NTF3 NGF BDNF

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GO Terms for Lumbosacral Plexus Lesion

Cellular components related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasmic vesicle	GO:0031410	9.65	SYP NTF4 NTF3 NGF BDNF
2	dendrite	GO:0030425	9.55	NTF4 NTF3 NGF NF1 BDNF
3	axon	GO:0030424	9.43	NTF4 NTF3 NGF NF1 CNTF BDNF
4	synaptic vesicle	GO:0008021	9.02	SYP NTF4 NTF3 NGF BDNF

Biological processes related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	nervous system development	GO:0007399	9.83	RBFOX3 NTF3 CNTF BDNF
2	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.78	NTF4 NTF3 NGF BDNF
3	memory	GO:0007613	9.73	NTF4 NTF3 NGF BDNF
4	negative regulation of neuron apoptotic process	GO:0043524	9.72	NTF4 NTF3 NGF CNTF BDNF
5	modulation of chemical synaptic transmission	GO:0050804	9.71	NTF4 NTF3 NGF BDNF
6	neuron projection morphogenesis	GO:0048812	9.67	NTF4 NTF3 NGF BDNF
7	neurotrophin TRK receptor signaling pathway	GO:0048011	9.63	NTF4 NGF BDNF
8	regulation of neuron differentiation	GO:0045664	9.56	NTF4 NTF3 NGF BDNF
9	extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	9.55	NGF NF1
10	activation of phospholipase C activity	GO:0007202	9.54	NTF4 BDNF
11	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.51	SYP NF1
12	positive regulation of collateral sprouting	GO:0048672	9.49	NGF BDNF
13	nerve development	GO:0021675	9.46	NTF4 NTF3 NGF BDNF
14	nerve growth factor signaling pathway	GO:0038180	9.26	NTF4 NTF3 NGF BDNF
15	peripheral nervous system development	GO:0007422	9.02	NTF4 NTF3 NGF NF1 BDNF

Molecular functions related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.02	NTF4 NTF3 NGF CNTF BDNF

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Sources for Lumbosacral Plexus Lesion

¹ BioSystems

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⁵⁴ Novoseek

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⁵⁶ OMIM

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⁷⁴ Wikipedia