Lumbosacral Plexus Lesion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Lumbosacral Plexus Lesion, also known as lumbosacral plexus lesions, is related to neurilemmoma and autoimmune optic neuritis. An important gene associated with Lumbosacral Plexus Lesion is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Neuroscience and MAPK signaling pathway. Affiliated tissues include spinal cord, and related phenotypes are nervous system and vision/eye

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Related Diseases for Lumbosacral Plexus Lesion

Diseases related to Lumbosacral Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)

#	Related Disease	Score	Top Affiliating Genes
1	neurilemmoma	29.5	SYP PMP22 NF1
2	autoimmune optic neuritis	10.1	CNTF AIF1
3	optic neuritis	10.1	CNTF BDNF
4	alzheimer disease 11	10.1	MAPT AIF1
5	amyotrophic lateral sclerosis 3	10.1	MAPT AIF1
6	polyradiculoneuropathy	10.1	PMP22 BDNF
7	diabetic polyneuropathy	10.0	CNTF BDNF
8	nonarteritic anterior ischemic optic neuropathy	10.0	CNTF AIF1
9	cauda equina syndrome	10.0	SYP PMP22
10	carotid artery occlusion	10.0	BDNF AIF1
11	occlusion precerebral artery	10.0	BDNF AIF1
12	cerebral artery occlusion	10.0	BDNF AIF1
13	degeneration of macula and posterior pole	10.0	CNTF AIF1
14	glaucoma, normal tension	10.0	CNTF BDNF
15	subleukemic leukemia	10.0	SYP AIF1
16	encephalomalacia	10.0	BDNF AIF1
17	periventricular leukomalacia	10.0	BDNF AIF1
18	subjective cognitive decline	10.0	MAPT BDNF
19	amyotrophy, hereditary neuralgic	10.0
20	amyotrophic neuralgia	10.0
21	plexopathy	10.0
22	brachial plexus neuropathy	10.0
23	pain agnosia	10.0	BDNF AIF1
24	agnosia	10.0	BDNF AIF1
25	binswanger's disease	10.0	SYP MAPT
26	intellectual developmental disorder, x-linked, syndromic, wilson-turner type	10.0	BDNF AIF1
27	amnestic disorder	10.0	MAPT BDNF
28	brachial plexus lesion	10.0	PMP22 NF1
29	aphasia	9.9	MAPT BDNF
30	sensory peripheral neuropathy	9.9	PMP22 CNTF BDNF
31	diabetic neuropathy	9.9	PMP22 CNTF BDNF
32	rete ovarii adenoma	9.9	NF1 AIF1
33	rete ovarii benign neoplasm	9.9	NF1 AIF1
34	mild cognitive impairment	9.9	MAPT BDNF
35	syndromic x-linked intellectual disability	9.9	BDNF AIF1
36	retinal ischemia	9.9	CNTF BDNF AIF1
37	exudative vitreoretinopathy 1	9.9	CNTF BDNF AIF1
38	syringomyelia	9.8	NF1 BDNF
39	vagus nerve neoplasm	9.8	SYP NF1
40	optic nerve astrocytoma	9.8	SYP NF1
41	subungual glomus tumor	9.8	SYP NF1
42	glomus tumor	9.8	SYP NF1
43	spinal cord oligodendroglioma	9.8	SYP NF1
44	extra-adrenal pheochromocytoma	9.8	SYP NF1
45	orbital cancer	9.8	SYP NF1
46	horner's syndrome	9.8	SYP NF1
47	cerebellum cancer	9.8	SYP NF1
48	adrenal medulla cancer	9.8	SYP NF1
49	malignant pheochromocytoma	9.8	SYP NF1
50	orbital disease	9.8	SYP NF1

Comorbidity relations with Lumbosacral Plexus Lesion via Phenotypic Disease Network (PDN):

Acute Cystitis

Hypertension, Essential

Graphical network of the top 20 diseases related to Lumbosacral Plexus Lesion:

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Symptoms & Phenotypes for Lumbosacral Plexus Lesion

MGI Mouse Phenotypes related to Lumbosacral Plexus Lesion:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.5	AIF1 BDNF CNTF MAPT NF1 PMP22
2	vision/eye	MP:0005391	9.02	AIF1 BDNF MAPT NF1 PMP22

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Drugs & Therapeutics for Lumbosacral Plexus Lesion

Search Clinical Trials, NIH Clinical Center for Lumbosacral Plexus Lesion

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Genetic Tests for Lumbosacral Plexus Lesion

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Anatomical Context for Lumbosacral Plexus Lesion

Organs/tissues related to Lumbosacral Plexus Lesion:

MalaCards : Spinal Cord

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Publications for Lumbosacral Plexus Lesion

Articles related to Lumbosacral Plexus Lesion:

#	Title	Authors	PMID	Year
1	Clinical Presentations of Lumbar Disc Degeneration and Lumbosacral Nerve Lesions. ⁶²	Liyew WA	32908535	2020
2	Diagnosis of brachial and lumbosacral plexus lesions. ⁶²	van Alfen N...Malessy MJ	23931788	2013
3	Lumbosacral plexus lesions. ⁶²	Stevanato G...Squintani G	17985537	2007
4	Multifocal acquired demyelinating sensory and motor neuropathy presenting as a peripheral nerve tumor. ⁶²	Allen DC...Mills KR	16609974	2006
5	Lumbosacral plexus lesions: correlation of clinical signs and computed tomography. ⁶²	Vock P...Mumenthaler M	3351532	1988
6	Late irradiation-induced lesions of the lumbosacral plexus. ⁶²	Aho K...Sainio K	6306507	1983

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Genes for Lumbosacral Plexus Lesion

Genes related to Lumbosacral Plexus Lesion (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PMP22	Peripheral Myelin Protein 22	Protein Coding	4.95	DISEASES inferred ¹⁴
2	CNTF	Ciliary Neurotrophic Factor	Protein Coding	4.26	DISEASES inferred ¹⁴
3	AIF1	Allograft Inflammatory Factor 1	Protein Coding	3.68	DISEASES inferred ¹⁴
4	MAPT	Microtubule Associated Protein Tau	Protein Coding	3.45	DISEASES inferred ¹⁴
5	SYP	Synaptophysin	Protein Coding	3.44	DISEASES inferred ¹⁴
6	NF1	Neurofibromin 1	Protein Coding	3.33	DISEASES inferred ¹⁴
7	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	3.08	DISEASES inferred ¹⁴

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Variations for Lumbosacral Plexus Lesion

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Expression for Lumbosacral Plexus Lesion

Search GEO for disease gene expression data for Lumbosacral Plexus Lesion.

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Pathways for Lumbosacral Plexus Lesion

Pathways related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ³	11.86	SYP NF1 MAPT
2	MAPK signaling pathway ⁷⁴	11.52	NF1 MAPT BDNF
3	MECP2 and associated Rett syndrome ⁷⁴	11.23	NF1 BDNF
4	BDNF-TrkB signaling ⁷⁴ Show member pathways Synaptic signaling pathways associated with autism spectrum disorder ⁷⁴	11.1	NF1 BDNF
5	Neurogenesis regulation in the olfactory epithelium ⁷⁴	11.01	MAPT BDNF
6	Neural Stem Cells and Lineage-specific Markers ⁶⁵	10.7	SYP CNTF BDNF

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GO Terms for Lumbosacral Plexus Lesion

Cellular components related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	glial cell projection	GO:0097386	9.26	MAPT AIF1
2	axon	GO:0030424	9.23	NF1 MAPT CNTF BDNF

Biological processes related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	microglial cell activation	GO:0001774	9.62	MAPT AIF1
2	Rac protein signal transduction	GO:0016601	9.56	NF1 AIF1
3	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.46	SYP NF1
4	astrocyte activation	GO:0048143	9.26	MAPT CNTF
5	peripheral nervous system development	GO:0007422	9.1	PMP22 NF1 BDNF

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Sources for Lumbosacral Plexus Lesion

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LMB001 MIFTS: 24	Lumbosacral Plexus Lesion Categories: Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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