MCID: LMB001
MIFTS: 29

Lumbosacral Plexus Lesion

Categories: Neuronal diseases

Aliases & Classifications for Lumbosacral Plexus Lesion

MalaCards integrated aliases for Lumbosacral Plexus Lesion:

Name: Lumbosacral Plexus Lesion 12 15 71
Lumbosacral Plexus Lesions 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13913
ICD9CM 34 353.1
SNOMED-CT 67 4062006
ICD10 32 S34.4
UMLS 71 C0154735

Summaries for Lumbosacral Plexus Lesion

MalaCards based summary : Lumbosacral Plexus Lesion, also known as lumbosacral plexus lesions, is related to autoimmune optic neuritis and alzheimer disease 17. An important gene associated with Lumbosacral Plexus Lesion is UNG (Uracil DNA Glycosylase), and among its related pathways/superpathways are Development HGF signaling pathway and MAPK signaling pathway. Affiliated tissues include spinal cord, eye and brain, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Lumbosacral Plexus Lesion

Diseases related to Lumbosacral Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 autoimmune optic neuritis 10.3 CNTF AIF1
2 alzheimer disease 17 10.1 RBFOX3 AIF1
3 middle ear carcinoma 10.1 SYP AIF1
4 cerebellar liponeurocytoma 10.1 SYP RBFOX3
5 clear cell ependymoma 10.1 SYP RBFOX3
6 gangliocytoma 10.1 SYP RBFOX3
7 cerebral artery occlusion 10.0 CNTF BDNF
8 carotid artery occlusion 10.0 RBFOX3 AIF1
9 cerebral ventricle cancer 10.0 SYP RBFOX3
10 optic nerve astrocytoma 10.0 SYP NF1
11 cerebrum cancer 10.0 SYP RBFOX3
12 punctate epithelial keratoconjunctivitis 10.0 NGF CNTF
13 amyotrophy, hereditary neuralgic 10.0
14 amyotrophic neuralgia 10.0
15 neurilemmoma 10.0
16 plexopathy 10.0
17 extra-adrenal pheochromocytoma 10.0 SYP NF1
18 supratentorial cancer 10.0 SYP RBFOX3
19 gliofibroma 9.9 SYP NF1
20 cerebellum cancer 9.9 SYP NF1
21 hypochondriasis 9.9 NTF4 NTF3 BDNF
22 cranial nerve neoplasm 9.9 SYP NF1
23 cauda equina neoplasm 9.9 SYP RPL24 RBFOX3
24 adrenal medulla cancer 9.9 SYP NF1
25 spinal cancer 9.9 SYP NF1
26 polyradiculopathy 9.9 RPL24 NGF
27 obstructive hydrocephalus 9.9 SYP NF1
28 autonomic nervous system benign neoplasm 9.9 SYP NF1
29 optic nerve disease 9.9 CNTF BDNF AIF1
30 peripheral nervous system benign neoplasm 9.9 SYP NF1
31 subleukemic leukemia 9.8 SYP RBFOX3 AIF1
32 adrenal gland pheochromocytoma 9.8 NGF BDNF
33 occlusion precerebral artery 9.8 RBFOX3 BDNF AIF1
34 encephalomalacia 9.8 RBFOX3 BDNF AIF1
35 diabetic autonomic neuropathy 9.8 NTF3 NGF
36 diabetic encephalopathy 9.8 NGF BDNF
37 askin's tumor 9.8 SYP NGF
38 ependymoblastoma 9.8 SYP NGF
39 chronic cystitis 9.8 NGF BDNF
40 exophthalmos 9.8 SYP NF1
41 neuropathy, hereditary sensory and autonomic, type v 9.8 NGF BDNF
42 cannabis abuse 9.7 NGF BDNF
43 mononeuritis of lower limb 9.7 NTF4 NTF3 NGF
44 lesion of sciatic nerve 9.7 NTF4 NTF3 NGF
45 cataract 38 9.7 NTF4 NTF3 NGF
46 diabetic polyneuropathy 9.7 NTF3 NGF
47 microvascular complications of diabetes 1 9.7 NTF3 NGF CNTF
48 diabetic neuropathy 9.7 NTF3 NGF CNTF
49 cardiovascular cancer 9.7 SYP NF1
50 spinal cord oligodendroglioma 9.7 SYP RBFOX3 NF1

Comorbidity relations with Lumbosacral Plexus Lesion via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Lumbosacral Plexus Lesion:



Diseases related to Lumbosacral Plexus Lesion

Symptoms & Phenotypes for Lumbosacral Plexus Lesion

MGI Mouse Phenotypes related to Lumbosacral Plexus Lesion:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 BDNF CNTF NF1 NGF NTF3 NTF4
2 nervous system MP:0003631 9.32 AIF1 BDNF CNTF NF1 NGF NTF3

Drugs & Therapeutics for Lumbosacral Plexus Lesion

Search Clinical Trials , NIH Clinical Center for Lumbosacral Plexus Lesion

Genetic Tests for Lumbosacral Plexus Lesion

Anatomical Context for Lumbosacral Plexus Lesion

MalaCards organs/tissues related to Lumbosacral Plexus Lesion:

40
Spinal Cord, Eye, Brain, Cerebellum, Adrenal Gland

Publications for Lumbosacral Plexus Lesion

Articles related to Lumbosacral Plexus Lesion:

# Title Authors PMID Year
1
Diagnosis of brachial and lumbosacral plexus lesions. 61
23931788 2013
2
Lumbosacral plexus lesions. 61
17985537 2007
3
Multifocal acquired demyelinating sensory and motor neuropathy presenting as a peripheral nerve tumor. 61
16609974 2006
4
Lumbosacral plexus lesions: correlation of clinical signs and computed tomography. 61
3351532 1988
5
Late irradiation-induced lesions of the lumbosacral plexus. 61
6306507 1983

Variations for Lumbosacral Plexus Lesion

Expression for Lumbosacral Plexus Lesion

Search GEO for disease gene expression data for Lumbosacral Plexus Lesion.

Pathways for Lumbosacral Plexus Lesion

Pathways related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 NTF4 NTF3 NGF BDNF
2 12.43 NTF4 NTF3 NGF NF1 BDNF
3
Show member pathways
12.42 NTF4 NTF3 NGF BDNF
4 12.31 SYP RBFOX3 NGF NF1
5
Show member pathways
12.3 NTF4 NTF3 NGF NF1 BDNF
6
Show member pathways
12.26 NTF4 NTF3 NGF BDNF
7
Show member pathways
12.13 NTF4 NTF3 NGF BDNF
8
Show member pathways
11.97 NTF4 NTF3 NGF BDNF
9 11.86 NTF3 NGF BDNF
10 11.42 NTF4 NTF3 NGF BDNF
11
Show member pathways
11.28 NTF4 NTF3 NGF BDNF
12 11.15 NTF3 NGF BDNF
13
Show member pathways
11.04 NTF4 NTF3 NGF BDNF
14 11 SYP NTF4 NTF3 NGF CNTF BDNF
15 10.75 NTF4 NTF3 NGF BDNF

GO Terms for Lumbosacral Plexus Lesion

Cellular components related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.65 SYP NTF4 NTF3 NGF BDNF
2 dendrite GO:0030425 9.55 NTF4 NTF3 NGF NF1 BDNF
3 axon GO:0030424 9.43 NTF4 NTF3 NGF NF1 CNTF BDNF
4 synaptic vesicle GO:0008021 9.02 SYP NTF4 NTF3 NGF BDNF

Biological processes related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.83 RBFOX3 NTF3 CNTF BDNF
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.78 NTF4 NTF3 NGF BDNF
3 memory GO:0007613 9.73 NTF4 NTF3 NGF BDNF
4 negative regulation of neuron apoptotic process GO:0043524 9.72 NTF4 NTF3 NGF CNTF BDNF
5 modulation of chemical synaptic transmission GO:0050804 9.71 NTF4 NTF3 NGF BDNF
6 neuron projection morphogenesis GO:0048812 9.67 NTF4 NTF3 NGF BDNF
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.63 NTF4 NGF BDNF
8 regulation of neuron differentiation GO:0045664 9.56 NTF4 NTF3 NGF BDNF
9 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.55 NGF NF1
10 activation of phospholipase C activity GO:0007202 9.54 NTF4 BDNF
11 regulation of long-term neuronal synaptic plasticity GO:0048169 9.51 SYP NF1
12 positive regulation of collateral sprouting GO:0048672 9.49 NGF BDNF
13 nerve development GO:0021675 9.46 NTF4 NTF3 NGF BDNF
14 nerve growth factor signaling pathway GO:0038180 9.26 NTF4 NTF3 NGF BDNF
15 peripheral nervous system development GO:0007422 9.02 NTF4 NTF3 NGF NF1 BDNF

Molecular functions related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.02 NTF4 NTF3 NGF CNTF BDNF

Sources for Lumbosacral Plexus Lesion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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