MCID: LMB001
MIFTS: 24

Lumbosacral Plexus Lesion

Categories: Neuronal diseases
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Aliases & Classifications for Lumbosacral Plexus Lesion

MalaCards integrated aliases for Lumbosacral Plexus Lesion:

Name: Lumbosacral Plexus Lesion 11 14 71
Lumbosacral Plexus Lesions 11

Classifications:



External Ids:

Disease Ontology 11 DOID:13913
ICD9CM 34 353.1
SNOMED-CT 68 4062006
ICD10 31 S34.4
UMLS 71 C0154735

Summaries for Lumbosacral Plexus Lesion

MalaCards based summary: Lumbosacral Plexus Lesion, also known as lumbosacral plexus lesions, is related to neurilemmoma and autoimmune optic neuritis. An important gene associated with Lumbosacral Plexus Lesion is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Neuroscience and MAPK signaling pathway. Affiliated tissues include spinal cord, and related phenotypes are nervous system and vision/eye

Related Diseases for Lumbosacral Plexus Lesion

Diseases related to Lumbosacral Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 29.5 SYP PMP22 NF1
2 autoimmune optic neuritis 10.1 CNTF AIF1
3 optic neuritis 10.1 CNTF BDNF
4 alzheimer disease 11 10.1 MAPT AIF1
5 amyotrophic lateral sclerosis 3 10.1 MAPT AIF1
6 polyradiculoneuropathy 10.1 PMP22 BDNF
7 diabetic polyneuropathy 10.0 CNTF BDNF
8 nonarteritic anterior ischemic optic neuropathy 10.0 CNTF AIF1
9 cauda equina syndrome 10.0 SYP PMP22
10 carotid artery occlusion 10.0 BDNF AIF1
11 occlusion precerebral artery 10.0 BDNF AIF1
12 cerebral artery occlusion 10.0 BDNF AIF1
13 degeneration of macula and posterior pole 10.0 CNTF AIF1
14 glaucoma, normal tension 10.0 CNTF BDNF
15 subleukemic leukemia 10.0 SYP AIF1
16 encephalomalacia 10.0 BDNF AIF1
17 periventricular leukomalacia 10.0 BDNF AIF1
18 subjective cognitive decline 10.0 MAPT BDNF
19 amyotrophy, hereditary neuralgic 10.0
20 amyotrophic neuralgia 10.0
21 plexopathy 10.0
22 brachial plexus neuropathy 10.0
23 pain agnosia 10.0 BDNF AIF1
24 agnosia 10.0 BDNF AIF1
25 binswanger's disease 10.0 SYP MAPT
26 intellectual developmental disorder, x-linked, syndromic, wilson-turner type 10.0 BDNF AIF1
27 amnestic disorder 10.0 MAPT BDNF
28 brachial plexus lesion 10.0 PMP22 NF1
29 aphasia 9.9 MAPT BDNF
30 sensory peripheral neuropathy 9.9 PMP22 CNTF BDNF
31 diabetic neuropathy 9.9 PMP22 CNTF BDNF
32 rete ovarii adenoma 9.9 NF1 AIF1
33 rete ovarii benign neoplasm 9.9 NF1 AIF1
34 mild cognitive impairment 9.9 MAPT BDNF
35 syndromic x-linked intellectual disability 9.9 BDNF AIF1
36 retinal ischemia 9.9 CNTF BDNF AIF1
37 exudative vitreoretinopathy 1 9.9 CNTF BDNF AIF1
38 syringomyelia 9.8 NF1 BDNF
39 vagus nerve neoplasm 9.8 SYP NF1
40 optic nerve astrocytoma 9.8 SYP NF1
41 subungual glomus tumor 9.8 SYP NF1
42 glomus tumor 9.8 SYP NF1
43 spinal cord oligodendroglioma 9.8 SYP NF1
44 extra-adrenal pheochromocytoma 9.8 SYP NF1
45 orbital cancer 9.8 SYP NF1
46 horner's syndrome 9.8 SYP NF1
47 cerebellum cancer 9.8 SYP NF1
48 adrenal medulla cancer 9.8 SYP NF1
49 malignant pheochromocytoma 9.8 SYP NF1
50 orbital disease 9.8 SYP NF1

Comorbidity relations with Lumbosacral Plexus Lesion via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Lumbosacral Plexus Lesion:



Diseases related to Lumbosacral Plexus Lesion

Symptoms & Phenotypes for Lumbosacral Plexus Lesion

MGI Mouse Phenotypes related to Lumbosacral Plexus Lesion:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.5 AIF1 BDNF CNTF MAPT NF1 PMP22
2 vision/eye MP:0005391 9.02 AIF1 BDNF MAPT NF1 PMP22

Drugs & Therapeutics for Lumbosacral Plexus Lesion

Search Clinical Trials, NIH Clinical Center for Lumbosacral Plexus Lesion

Genetic Tests for Lumbosacral Plexus Lesion

Anatomical Context for Lumbosacral Plexus Lesion

Organs/tissues related to Lumbosacral Plexus Lesion:

MalaCards : Spinal Cord

Publications for Lumbosacral Plexus Lesion

Articles related to Lumbosacral Plexus Lesion:

# Title Authors PMID Year
1
Clinical Presentations of Lumbar Disc Degeneration and Lumbosacral Nerve Lesions. 62
32908535 2020
2
Diagnosis of brachial and lumbosacral plexus lesions. 62
23931788 2013
3
Lumbosacral plexus lesions. 62
17985537 2007
4
Multifocal acquired demyelinating sensory and motor neuropathy presenting as a peripheral nerve tumor. 62
16609974 2006
5
Lumbosacral plexus lesions: correlation of clinical signs and computed tomography. 62
3351532 1988
6
Late irradiation-induced lesions of the lumbosacral plexus. 62
6306507 1983

Variations for Lumbosacral Plexus Lesion

Expression for Lumbosacral Plexus Lesion

Search GEO for disease gene expression data for Lumbosacral Plexus Lesion.

Pathways for Lumbosacral Plexus Lesion

Pathways related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.86 SYP NF1 MAPT
2 11.52 NF1 MAPT BDNF
3 11.23 NF1 BDNF
4
Show member pathways
11.1 NF1 BDNF
5 11.01 MAPT BDNF
6 10.7 SYP CNTF BDNF

GO Terms for Lumbosacral Plexus Lesion

Cellular components related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glial cell projection GO:0097386 9.26 MAPT AIF1
2 axon GO:0030424 9.23 NF1 MAPT CNTF BDNF

Biological processes related to Lumbosacral Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microglial cell activation GO:0001774 9.62 MAPT AIF1
2 Rac protein signal transduction GO:0016601 9.56 NF1 AIF1
3 regulation of long-term neuronal synaptic plasticity GO:0048169 9.46 SYP NF1
4 astrocyte activation GO:0048143 9.26 MAPT CNTF
5 peripheral nervous system development GO:0007422 9.1 PMP22 NF1 BDNF

Sources for Lumbosacral Plexus Lesion

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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