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MCID: LMN006
MIFTS: 35

Luminal Breast Carcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Luminal Breast Carcinoma

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MalaCards integrated aliases for Luminal Breast Carcinoma:

Name: Luminal Breast Carcinoma 12 15
Breast Tumor Luminal 12 17
Luminal Breast Cancer 12

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060548
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Summaries for Luminal Breast Carcinoma

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MalaCards based summary : Luminal Breast Carcinoma, also known as breast tumor luminal, is related to in situ carcinoma and ductal carcinoma in situ. An important gene associated with Luminal Breast Carcinoma is MTOR (Mechanistic Target Of Rapamycin Kinase), and among its related pathways/superpathways are Downstream signaling events of B Cell Receptor (BCR) and Gastric cancer. Affiliated tissues include breast, testes and lung, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Luminal Breast Carcinoma

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Diseases related to Luminal Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 29.9 ERBB2 ESR1 KRT5 PGR
2 ductal carcinoma in situ 29.4 AKT1 ERBB2 ESR1 KRT5 PGR
3 breast cancer 28.2 AKT1 ERBB2 ERBB3 ESR1 FOXA1 GATA3
4 vestibular gland benign neoplasm 10.4 ESR1 PGR
5 bartholin's gland adenoma 10.4 ESR1 PGR
6 vulvar syringoma 10.4 ESR1 PGR
7 lung leiomyoma 10.4 ESR1 PGR
8 scirrhous adenocarcinoma 10.4 ERBB2 PGR
9 breast apocrine carcinoma 10.4 ERBB2 PGR
10 comedo carcinoma 10.4 ERBB2 ESR1
11 vulvar benign neoplasm 10.4 ESR1 PGR
12 trigonitis 10.4 ESR1 PGR
13 vulvar leiomyoma 10.4 ESR1 PGR
14 predominantly cortical thymoma 10.4 ESR1 PGR
15 intracystic papillary adenoma 10.3 ERBB2 PGR
16 oncocytic breast carcinoma 10.3 ESR1 PGR
17 progesterone-receptor negative breast cancer 10.3 ERBB2 PGR
18 progesterone resistance 10.3 ESR1 PGR
19 endometrial squamous cell carcinoma 10.3 ESR1 PGR
20 endometrial mucinous adenocarcinoma 10.3 ESR1 PGR
21 adenoid basal cell carcinoma 10.3 ESR1 PGR
22 peritoneal benign neoplasm 10.3 ESR1 PGR
23 gender identity disorder 10.3 ESR1 PGR
24 deep angioma 10.3 ESR1 PGR
25 diffuse peritoneal leiomyomatosis 10.3 ESR1 PGR
26 synchronous bilateral breast carcinoma 10.3 ESR1 PGR
27 female reproductive endometrioid cancer 10.3 ESR1 PGR
28 large cell acanthoma 10.3 KRT5 MTOR
29 uterine body mixed cancer 10.3 ERBB2 PGR
30 cervical carcinosarcoma 10.3 ESR1 PGR
31 breast cystic hypersecretory carcinoma 10.3 ERBB2 KRT5
32 retroperitoneal leiomyosarcoma 10.3 ERBB3 PGR
33 estrogen excess 10.2 ESR1 PGR
34 angiomyolipoma 10.2 ESR1 MTOR PGR
35 glassy cell carcinoma of the cervix 10.2 ERBB2 ESR1 PGR
36 intramuscular hemangioma 10.2 ESR1 PGR
37 breast medullary carcinoma 10.2 ERBB2 ESR1 PGR
38 breast scirrhous carcinoma 10.2 ERBB2 ESR1 PGR
39 progesterone-receptor positive breast cancer 10.2 ERBB2 ESR1 PGR
40 breast adenoid cystic carcinoma 10.2 ERBB2 ESR1 PGR
41 inflammatory breast carcinoma 10.2 ERBB2 ESR1 PGR
42 uterine corpus cancer 10.2 ERBB2 ESR1 PGR
43 lymphangioleiomyomatosis 10.2 ESR1 MTOR PGR
44 glycogen-rich clear cell breast carcinoma 10.2 ESR1 PGR
45 mammary paget's disease 10.2 ERBB2 ESR1 PGR
46 tubular adenocarcinoma 10.2 ERBB2 ESR1 PGR
47 fallopian tube carcinoma 10.2 ERBB2 ESR1 PGR
48 breast fibroadenoma 10.2 ERBB2 ESR1 PGR
49 female breast cancer 10.2 ERBB2 ESR1 PGR
50 breast squamous cell carcinoma 10.2 ERBB2 KRT5

Graphical network of the top 20 diseases related to Luminal Breast Carcinoma:



Diseases related to Luminal Breast Carcinoma
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Symptoms & Phenotypes for Luminal Breast Carcinoma

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GenomeRNAi Phenotypes related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

27 (show all 38)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.05 MTOR
2 Decreased viability GR00106-A-0 10.05 ERBB3
3 Decreased viability GR00221-A-1 10.05 AKT1 ESR1 MTOR
4 Decreased viability GR00221-A-2 10.05 AKT1 ERBB3 ESR1
5 Decreased viability GR00221-A-3 10.05 AKT1 ERBB2
6 Decreased viability GR00221-A-4 10.05 AKT1 ERBB2 ERBB3 ESR1 MTOR
7 Decreased viability GR00301-A 10.05 ERBB3
8 Decreased viability GR00342-S-1 10.05 MTOR
9 Decreased viability GR00342-S-2 10.05 ERBB3 MTOR
10 Decreased viability GR00342-S-3 10.05 ERBB3
11 Decreased viability GR00402-S-2 10.05 AKT1 ERBB2 ERBB3 ESR1 MTOR
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.9 ERBB2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.9 MTOR
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.9 AKT1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.9 ERBB3
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.9 ERBB3 MTOR
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.9 AKT1 ERBB2 ERBB3 MTOR
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.9 ERBB2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.78 MTOR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.78 MTOR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.78 FOXA1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.78 ERBB3 FOXA1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.78 ERBB3
24 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.78 FOXA1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.78 FOXA1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.78 AKT1 ERBB3 FOXA1 MTOR
27 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.78 AKT1 FOXA1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.78 FOXA1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.78 ERBB3
30 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.78 FOXA1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 FOXA1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.78 AKT1 FOXA1 MTOR
33 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.78 AKT1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.78 FOXA1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.78 AKT1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.78 MTOR
37 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.78 AKT1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 AKT1 ERBB3 MTOR

MGI Mouse Phenotypes related to Luminal Breast Carcinoma:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.16 AKT1 ERBB2 ERBB3 ESR1 GATA3 KDM4C
2 growth/size/body region MP:0005378 10.13 AKT1 ERBB2 ERBB3 ESR1 FOXA1 GATA3
3 endocrine/exocrine gland MP:0005379 10.06 AKT1 ERBB2 ERBB3 ESR1 FOXA1 GATA3
4 immune system MP:0005387 10.06 AKT1 ERBB3 ESR1 FOXA1 GATA3 KDM4C
5 embryo MP:0005380 10.02 AKT1 ERBB2 ERBB3 ESR1 GATA3 MTOR
6 mortality/aging MP:0010768 10.02 AKT1 ERBB2 ERBB3 ESR1 FOXA1 GATA3
7 digestive/alimentary MP:0005381 9.97 ERBB2 ERBB3 ESR1 FOXA1 GATA3 KRT5
8 integument MP:0010771 9.97 AKT1 ERBB2 ERBB3 ESR1 FOXA1 GATA3
9 muscle MP:0005369 9.8 AKT1 ERBB2 ERBB3 ESR1 GATA3 MTOR
10 neoplasm MP:0002006 9.7 AKT1 ERBB2 ERBB3 ESR1 FOXA1 KDM4C
11 no phenotypic analysis MP:0003012 9.43 ESR1 GATA3 KDM4C KRT5 MTOR PGR
12 normal MP:0002873 9.17 AKT1 ERBB2 ERBB3 ESR1 GATA3 MTOR
Sources

Drugs & Therapeutics for Luminal Breast Carcinoma

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Search Clinical Trials , NIH Clinical Center for Luminal Breast Carcinoma

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Genetic Tests for Luminal Breast Carcinoma

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Anatomical Context for Luminal Breast Carcinoma

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MalaCards organs/tissues related to Luminal Breast Carcinoma:

42
Breast, Testes, Lung, Ovary, Cervix
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Publications for Luminal Breast Carcinoma

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Articles related to Luminal Breast Carcinoma:

# Title Authors Year
1
First French Pilot Quality Assessment of the EndoPredict Test for Early Luminal Breast Carcinoma. ( 29715116 )
2018
2
Comparison of visual assessment and image analysis in the evaluation of Ki-67 expression and their prognostic significance in immunohistochemically defined luminal breast carcinoma. ( 27511992 )
2016
3
p-mTOR expression is associated with better prognosis in luminal breast carcinoma. ( 25053543 )
2014
4
Her2 negative luminal breast carcinoma and Ki-67 evaluation. ( 22647834 )
2012
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Variations for Luminal Breast Carcinoma

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Expression for Luminal Breast Carcinoma

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Search GEO for disease gene expression data for Luminal Breast Carcinoma.
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Pathways for Luminal Breast Carcinoma

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Pathways related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Downstream signaling events of B Cell Receptor (BCR) 67
Show member pathways
 12.58 AKT1 ERBB2 ERBB3 MTOR
2
Gastric cancer 38
Show member pathways
 12.5 AKT1 ERBB2 ESR1 MTOR PGR
3
Glioma 38
Show member pathways
 12.45 AKT1 ERBB2 ERBB3 ESR1 MTOR
4
ErbB signaling pathway 1 38
Show member pathways
 12.43 AKT1 ERBB2 ERBB3 MTOR
5
Development HGF signaling pathway 23
Show member pathways
 12.4 AKT1 ERBB2 ERBB3 ESR1 MTOR
6
Development EGFR signaling pathway 23
Show member pathways
 12.39 AKT1 ERBB2 ERBB3 MTOR
7
mTOR signaling pathway (KEGG) 38
Show member pathways
 12.35 AKT1 ERBB2 ERBB3 MTOR
8
Apoptosis Pathway 73
Show member pathways
 12.25 AKT1 ERBB2 ERBB3 MTOR
9
Development Ligand-independent activation of ESR1 and ESR2 23
Show member pathways
 12.1 AKT1 ERBB2 ERBB3 ESR1
10
EGF/EGFR Signaling Pathway 1
12.04 AKT1 ERBB2 MTOR
11
MAPK Signaling: Mitogen Stimulation Pathway 66
Show member pathways
 12.03 AKT1 ERBB2 ERBB3 MTOR
12
Integrated Breast Cancer Pathway 1
12.01 AKT1 ESR1 MTOR
13
Transcription Androgen Receptor nuclear signaling 23
Show member pathways
 11.97 AKT1 ERBB2 MTOR
14
Signaling by PTK6 67
Show member pathways
 11.92 AKT1 ERBB2 ERBB3
15
MAPK Pathway 73
Show member pathways
 11.89 AKT1 ERBB2 ERBB3
16
AKT Signaling Pathway 68
11.86 AKT1 ERBB2 ERBB3 MTOR
17
Thyroid hormone signaling pathway 38
11.85 AKT1 ESR1 MTOR
18
Prolactin Signaling Pathway 1 38
Show member pathways
 11.81 AKT1 ELF5 ERBB2 ESR1 MTOR
19
HIF-1 signaling pathway 38
11.77 AKT1 ERBB2 MTOR
20
TGF-beta Signaling Pathways 66
11.75 AKT1 ESR1 MTOR
21
Glucocorticoid receptor regulatory network 1
11.66 AKT1 GATA3 KRT5
22
Regulation of nuclear SMAD2/3 signaling 1
11.6 AKT1 ESR1 GATA3
23
Regulation of Telomerase 1
11.51 AKT1 ESR1 MTOR
24
Signaling by ERBB4 67
Show member pathways
 11.49 ERBB2 ERBB3 ESR1 PGR
25
Central carbon metabolism in cancer 38
11.48 AKT1 ERBB2 MTOR
26
Proteoglycans in cancer 38
11.32 AKT1 ERBB2 ERBB3 ESR1 MTOR
27
G-protein signaling_Cross-talk between Ras-family GTPases 23
11.24 AKT1 ERBB2 ERBB3 MTOR
28
Estrogen signaling pathway 1
11 AKT1 ESR1
29
a6b1 and a6b4 Integrin signaling 1
10.99 AKT1 ERBB2 ERBB3
30
Extracellular vesicle-mediated signaling in recipient cells 1
10.91 AKT1 ERBB2 MTOR
31
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression 1
10.88 AKT1 MTOR
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GO Terms for Luminal Breast Carcinoma

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Cellular components related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.65 AKT1 CSPP1 ELF5 ERBB2 ESR1 KRT5
2 nucleus GO:0005634 9.36 AKT1 ELF5 ERBB2 ESR1 FOXA1 GATA3

Biological processes related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.93 AKT1 ELF5 ESR1 FOXA1 GATA3 PGR
2 positive regulation of gene expression GO:0010628 9.73 AKT1 ERBB2 ERBB3 GATA3 KDM4C MTOR
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.72 AKT1 ESR1 FOXA1
4 negative regulation of gene expression GO:0010629 9.71 AKT1 ESR1 GATA3 PGR
5 wound healing GO:0042060 9.7 ERBB2 ERBB3 MTOR
6 chromatin remodeling GO:0006338 9.65 ESR1 FOXA1 GATA3
7 anatomical structure formation involved in morphogenesis GO:0048646 9.59 FOXA1 GATA3
8 uterus development GO:0060065 9.58 ESR1 GATA3
9 positive regulation of lipid biosynthetic process GO:0046889 9.58 AKT1 MTOR
10 regulation of myelination GO:0031641 9.57 AKT1 MTOR
11 negative regulation of macroautophagy GO:0016242 9.54 AKT1 MTOR
12 anoikis GO:0043276 9.51 AKT1 MTOR
13 TOR signaling GO:0031929 9.5 AKT1 GATA3 MTOR
14 negative regulation of cell size GO:0045792 9.43 AKT1 MTOR
15 regulation of glycogen biosynthetic process GO:0005979 9.37 AKT1 MTOR
16 positive regulation of protein kinase B signaling GO:0051897 9.35 ERBB2 ERBB3 ESR1 GATA3 MTOR
17 mammary gland epithelial cell differentiation GO:0060644 9.33 AKT1 ELF5 ZNF703
18 positive regulation of transcription by RNA polymerase III GO:0045945 9.19 MTOR
19 phosphatidylinositol 3-kinase signaling GO:0014065 8.92 AKT1 ERBB2 ERBB3 GATA3
20 regulation of transcription by RNA polymerase II GO:0006357 10.03 ELF5 ERBB2 ESR1 FOXA1 GATA3 KDM4C

Molecular functions related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.77 ELF5 ESR1 FOXA1 GATA3 PGR
2 sequence-specific DNA binding GO:0043565 9.65 ELF5 ESR1 FOXA1 GATA3 PGR
3 nucleotide binding GO:0000166 9.5 ERBB2 ERBB3 MTOR
4 identical protein binding GO:0042802 9.43 AKT1 ERBB2 ERBB3 ESR1 MTOR PGR
5 nitric-oxide synthase regulator activity GO:0030235 9.16 AKT1 ESR1
6 enzyme binding GO:0019899 9.02 AKT1 ESR1 KDM4C PGR PREX1
Sources

Sources for Luminal Breast Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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