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MCID: LMN006
MIFTS: 33

Luminal Breast Carcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Luminal Breast Carcinoma

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MalaCards integrated aliases for Luminal Breast Carcinoma:

Name: Luminal Breast Carcinoma 12 15
Luminal Breast Cancer 12
Breast Tumor Luminal 12

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060548
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Summaries for Luminal Breast Carcinoma

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MalaCards based summary : Luminal Breast Carcinoma, also known as luminal breast cancer, is related to ductal carcinoma in situ and breast cancer. An important gene associated with Luminal Breast Carcinoma is MTOR (Mechanistic Target Of Rapamycin Kinase), and among its related pathways/superpathways are ErbB4 Pathway and Downstream signaling events of B Cell Receptor (BCR). Affiliated tissues include testes, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Luminal Breast Carcinoma

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Diseases related to Luminal Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 ductal carcinoma in situ 29.9 EGFR ERBB2 ESR1 PGR
2 breast cancer 25.2 BCAS1 EGFR ERBB2 ERBB3 ESR1 FOXA1
3 scirrhous adenocarcinoma 10.8 ERBB2 PGR
4 breast apocrine carcinoma 10.8 ERBB2 PGR
5 comedo carcinoma 10.8 ERBB2 ESR1
6 vulvar syringoma 10.8 ESR1 PGR
7 lung leiomyoma 10.8 ESR1 PGR
8 breast intraductal proliferative lesion 10.8 EGFR ERBB2
9 vestibular gland benign neoplasm 10.8 ESR1 PGR
10 bartholin's gland adenoma 10.7 ESR1 PGR
11 breast mucoepidermoid carcinoma 10.7 ERBB2 PGR
12 vulvar benign neoplasm 10.7 ESR1 PGR
13 breast metaplastic carcinoma 10.7 ERBB2 PGR
14 trigonitis 10.7 ESR1 PGR
15 vulvar leiomyoma 10.7 ESR1 PGR
16 predominantly cortical thymoma 10.7 ESR1 PGR
17 paronychia 10.7 EGFR MTOR
18 progesterone resistance 10.7 ESR1 PGR
19 cribriform carcinoma 10.7 ESR1 PGR
20 endometrial squamous cell carcinoma 10.7 ESR1 PGR
21 endometrial mucinous adenocarcinoma 10.7 ESR1 PGR
22 adenoid basal cell carcinoma 10.7 ESR1 PGR
23 gender identity disorder 10.6 ESR1 PGR
24 deep angioma 10.6 ESR1 PGR
25 uterine body mixed cancer 10.6 ERBB2 PGR
26 synchronous bilateral breast carcinoma 10.6 ESR1 PGR
27 cervical carcinosarcoma 10.6 ESR1 PGR
28 estrogen excess 10.6 ESR1 PGR
29 intramuscular hemangioma 10.6 ESR1 PGR
30 glycogen-rich clear cell breast carcinoma 10.6 ESR1 PGR
31 mammographic density 10.5 ESR1 PGR
32 glassy cell carcinoma of the cervix 10.5 ERBB2 ESR1 PGR
33 breast medullary carcinoma 10.5 ERBB2 ESR1 PGR
34 retinitis pigmentosa 47 10.5 ESR1 PGR
35 progesterone-receptor positive breast cancer 10.5 ERBB2 ESR1 PGR
36 apocrine adenocarcinoma 10.5 ERBB2 ESR1 PGR
37 uterine corpus cancer 10.5 ERBB2 ESR1 PGR
38 breast benign neoplasm 10.5 ERBB2 ESR1 PGR
39 thoracic benign neoplasm 10.5 ERBB2 ESR1 PGR
40 mixed cell type cancer 10.5 ERBB2 ESR1 PGR
41 angiomyolipoma 10.5 ESR1 MTOR PGR
42 bilateral breast cancer 10.5 ERBB2 ESR1 PGR
43 breast papillary carcinoma 10.5 ERBB2 ESR1 PGR
44 fallopian tube carcinoma 10.5 ERBB2 ESR1 PGR
45 exanthem 10.5 EGFR ERBB2 MTOR
46 sweat gland cancer 10.5 ERBB2 ESR1 PGR
47 breast fibroadenoma 10.5 ERBB2 ESR1 PGR
48 adenomyosis 10.5 ESR1 PGR
49 female breast cancer 10.5 ERBB2 ESR1 PGR
50 hidradenocarcinoma 10.5 EGFR ERBB2 ESR1

Graphical network of the top 20 diseases related to Luminal Breast Carcinoma:



Diseases related to Luminal Breast Carcinoma
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Symptoms & Phenotypes for Luminal Breast Carcinoma

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GenomeRNAi Phenotypes related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

26 (show top 50) (show all 59)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.23 EGFR MTOR
2 Decreased viability GR00106-A-0 10.23 ERBB3
3 Decreased viability GR00221-A-1 10.23 ESR1 EGFR MTOR
4 Decreased viability GR00221-A-2 10.23 ESR1 ERBB3
5 Decreased viability GR00221-A-3 10.23 ERBB2
6 Decreased viability GR00221-A-4 10.23 ERBB2 ESR1 ERBB3 EGFR MTOR
7 Decreased viability GR00301-A 10.23 ERBB3
8 Decreased viability GR00342-S-1 10.23 MTOR
9 Decreased viability GR00342-S-2 10.23 ERBB3 MTOR
10 Decreased viability GR00342-S-3 10.23 ERBB3
11 Decreased viability GR00402-S-2 10.23 ERBB2 ESR1 ERBB3 EGFR MTOR
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 10.2 FOXA1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 10.2 TFAP2C
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 10.2 TFAP2C
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.2 MTOR
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 10.2 TFAP2C
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.2 ERBB3 FOXA1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 10.2 FOXA1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.2 ERBB3 TFAP2C FOXA1 MTOR
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.2 ERBB3 MTOR
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.2 TFAP2C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.17 MTOR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.17 MTOR
24 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.17 TFAP2C FOXA1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.17 ERBB3 FOXA1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.17 EGFR
27 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.17 ERBB3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.17 EGFR
29 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.17 TFAP2C FOXA1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.17 TFAP2C
31 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.17 FOXA1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.17 TFAP2C
33 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.17 ERBB3 TFAP2C MTOR FOXA1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.17 ERBB2 TFAP2C
35 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.17 ERBB2
36 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.17 ERBB2
37 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.17 FOXA1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.17 FOXA1
39 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.17 EGFR
40 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.17 ERBB3
41 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.17 FOXA1
42 Increased shRNA abundance (Z-score > 2) GR00366-A-207 10.17 ERBB2
43 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.17 EGFR
44 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.17 FOXA1 EGFR TFAP2C
45 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.17 ERBB2
46 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.17 MTOR FOXA1
47 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.17 EGFR
48 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.17 TFAP2C FOXA1
49 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.17 TFAP2C
50 Increased shRNA abundance (Z-score > 2) GR00366-A-6 10.17 TFAP2C

MGI Mouse Phenotypes related to Luminal Breast Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 10.01 EGFR ERBB2 GATA3 MTOR ERBB3 PGR
2 endocrine/exocrine gland MP:0005379 9.97 ESR1 EGFR FOXA1 ERBB2 GATA3 MTOR
3 growth/size/body region MP:0005378 9.97 PREX1 ESR1 EGFR FOXA1 GATA3 ERBB2
4 digestive/alimentary MP:0005381 9.91 ESR1 EGFR FOXA1 GATA3 ERBB2 ERBB3
5 integument MP:0010771 9.8 ESR1 EGFR FOXA1 GATA3 ERBB2 ERBB3
6 muscle MP:0005369 9.7 ESR1 EGFR ERBB2 GATA3 MTOR ERBB3
7 neoplasm MP:0002006 9.43 ESR1 EGFR FOXA1 ERBB2 ERBB3 PGR
8 normal MP:0002873 9.23 EGFR ERBB2 GATA3 MTOR ERBB3 PGR
Sources

Drugs & Therapeutics for Luminal Breast Carcinoma

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Search Clinical Trials , NIH Clinical Center for Luminal Breast Carcinoma

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Genetic Tests for Luminal Breast Carcinoma

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Anatomical Context for Luminal Breast Carcinoma

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MalaCards organs/tissues related to Luminal Breast Carcinoma:

41
Testes
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Publications for Luminal Breast Carcinoma

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Articles related to Luminal Breast Carcinoma:

# Title Authors Year
1
First French Pilot Quality Assessment of the EndoPredict Test for Early Luminal Breast Carcinoma. ( 29715116 )
2018
2
Comparison of visual assessment and image analysis in the evaluation of Ki-67 expression and their prognostic significance in immunohistochemically defined luminal breast carcinoma. ( 27511992 )
2016
3
p-mTOR expression is associated with better prognosis in luminal breast carcinoma. ( 25053543 )
2014
4
Loss of heterozygosity at 13q13 and 14q32 predicts BRCA2 inactivation in luminal breast carcinomas. ( 23754601 )
2013
5
Her2 negative luminal breast carcinoma and Ki-67 evaluation. ( 22647834 )
2012
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Variations for Luminal Breast Carcinoma

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Expression for Luminal Breast Carcinoma

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Search GEO for disease gene expression data for Luminal Breast Carcinoma.
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Pathways for Luminal Breast Carcinoma

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Pathways related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
ErbB4 Pathway 64
Show member pathways
 12.64 EGFR ERBB2 ERBB3 MTOR
2
Downstream signaling events of B Cell Receptor (BCR) 66
Show member pathways
 12.57 EGFR ERBB2 ERBB3 MTOR
3
Development HGF signaling pathway 22
Show member pathways
 12.56 ERBB2 ERBB3 ESR1 MTOR
4
Glioma 37
Show member pathways
 12.52 EGFR ERBB2 ERBB3 ESR1 MTOR
5
Gastric cancer 37
Show member pathways
 12.5 EGFR ERBB2 ESR1 MTOR PGR
6
Development EGFR signaling pathway 22
Show member pathways
 12.39 EGFR ERBB2 ERBB3 MTOR
7
MicroRNAs in cancer 37
12.36 EGFR ERBB2 ERBB3 MTOR
8
mTOR signaling pathway (KEGG) 65
Show member pathways
 12.34 EGFR ERBB2 ERBB3 MTOR
9
Prolactin Signaling Pathway 1 37
Show member pathways
 12.32 ELF5 ERBB2 ESR1 MTOR
10
ErbB signaling pathway 1 37
Show member pathways
 12.31 EGFR ERBB2 ERBB3 MTOR
11
Apoptosis Pathway 72
Show member pathways
 12.27 EGFR ERBB2 ERBB3 MTOR
12
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.12 EGFR ERBB2 ERBB3 ESR1
13
EGF/EGFR Signaling Pathway 1
12.04 EGFR ERBB2 MTOR
14
Integrated Breast Cancer Pathway 1
12 EGFR ESR1 MTOR
15
Tyrosine Kinases / Adaptors 4
11.97 EGFR ERBB2 ERBB3
16
AKT Signaling Pathway 67
11.97 EGFR ERBB2 ERBB3 MTOR
17
Transcription Androgen Receptor nuclear signaling 22
Show member pathways
 11.96 EGFR ERBB2 MTOR
18
Signaling by PTK6 66
Show member pathways
 11.9 EGFR ERBB2 ERBB3
19
MAPK Pathway 72
Show member pathways
 11.87 EGFR ERBB2 ERBB3
20
HIF-1 signaling pathway 37
11.77 EGFR ERBB2 MTOR
21
Proteoglycans in cancer 37
11.66 EGFR ERBB2 ERBB3 ESR1 MTOR
22
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 11.64 EGFR ERBB2 ERBB3 MTOR
23
Regulation of Telomerase 1
11.53 EGFR ESR1 MTOR
24
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 66
Show member pathways
 11.53 EGFR ERBB2 ESR1 TFAP2C
25
Central carbon metabolism in cancer 37
11.51 EGFR ERBB2 MTOR
26
Agrin Interactions at Neuromuscular Junction 64
11.4 EGFR ERBB2 ERBB3
27
Alzheimers Disease Pathway 64
11.23 EGFR ERBB2 ERBB3
28
EGFR Transactivation by Gastrin 66
Show member pathways
 11.07 EGFR MTOR
29
Signaling by ERBB4 66
Show member pathways
 11.05 EGFR ERBB2 ERBB3 ESR1 PGR
30
a6b1 and a6b4 Integrin signaling 1
11.04 EGFR ERBB2 ERBB3
31
Extracellular vesicle-mediated signaling in recipient cells 1
10.97 EGFR ERBB2 MTOR
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GO Terms for Luminal Breast Carcinoma

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Cellular components related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.7 BCAS1 CSPP1 EGFR ELF5 ERBB2 ERBB3
2 basal plasma membrane GO:0009925 8.8 EGFR ERBB2 ERBB3

Biological processes related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 EGFR ELF5 ESR1 FOXA1 GATA3 PGR
2 positive regulation of gene expression GO:0010628 9.92 ERBB2 ERBB3 GATA3 MTOR
3 transcription by RNA polymerase II GO:0006366 9.92 ELF5 ESR1 FOXA1 GATA3 TFAP2C
4 peptidyl-tyrosine phosphorylation GO:0018108 9.82 EGFR ERBB2 ERBB3
5 positive regulation of protein phosphorylation GO:0001934 9.81 EGFR ERBB2 MTOR
6 positive regulation of MAPK cascade GO:0043410 9.81 EGFR ERBB2 ERBB3
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.79 EGFR ERBB2 ERBB3
8 negative regulation of signal transduction GO:0009968 9.77 EGFR ERBB2 ERBB3
9 chromatin remodeling GO:0006338 9.76 ESR1 FOXA1 GATA3
10 male gonad development GO:0008584 9.75 ESR1 GATA3 TFAP2C
11 response to estradiol GO:0032355 9.72 EGFR ESR1 FOXA1
12 positive regulation of kinase activity GO:0033674 9.67 EGFR ERBB2 ERBB3
13 peripheral nervous system development GO:0007422 9.64 ERBB2 ERBB3
14 anatomical structure formation involved in morphogenesis GO:0048646 9.63 FOXA1 GATA3
15 ERBB2 signaling pathway GO:0038128 9.63 EGFR ERBB2 ERBB3
16 uterus development GO:0060065 9.61 ESR1 GATA3
17 cellular response to estradiol stimulus GO:0071392 9.61 EGFR ESR1 ZNF703
18 TOR signaling GO:0031929 9.59 GATA3 MTOR
19 mammary gland epithelial cell differentiation GO:0060644 9.57 ELF5 ZNF703
20 phosphatidylinositol phosphorylation GO:0046854 9.56 EGFR ERBB2 ERBB3 ESR1
21 positive regulation of transcription by RNA polymerase III GO:0045945 9.54 ERBB2 MTOR
22 phosphatidylinositol 3-kinase signaling GO:0014065 9.54 ERBB2 ERBB3 GATA3
23 regulation of cell motility GO:2000145 9.5 EGFR ERBB2 ERBB3
24 wound healing GO:0042060 9.46 EGFR ERBB2 ERBB3 MTOR
25 negative regulation of ERBB signaling pathway GO:1901185 9.13 EGFR ERBB2 ERBB3
26 positive regulation of protein kinase B signaling GO:0051897 9.1 EGFR ERBB2 ERBB3 ESR1 GATA3 MTOR
27 signal transduction GO:0007165 10.17 EGFR ERBB2 ERBB3 ESR1 GATA3 MTOR
28 regulation of transcription, DNA-templated GO:0006355 10.16 ELF5 ERBB2 ESR1 FOXA1 GATA3 PGR
29 transcription, DNA-templated GO:0006351 10.11 ELF5 ERBB2 ESR1 FOXA1 GATA3 PGR
30 regulation of transcription by RNA polymerase II GO:0006357 10.02 EGFR ELF5 ERBB2 ESR1 FOXA1 GATA3

Molecular functions related to Luminal Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.93 ELF5 ESR1 FOXA1 GATA3 PGR TFAP2C
2 identical protein binding GO:0042802 9.91 EGFR ERBB2 ERBB3 ESR1 MTOR PGR
3 sequence-specific DNA binding GO:0043565 9.88 ELF5 ESR1 FOXA1 GATA3 PGR
4 nucleotide binding GO:0000166 9.83 EGFR ERBB2 ERBB3 MTOR
5 enzyme binding GO:0019899 9.81 EGFR ESR1 PGR PREX1
6 protein tyrosine kinase activity GO:0004713 9.72 EGFR ERBB2 ERBB3
7 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 9.71 ELF5 FOXA1 GATA3
8 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.67 EGFR ERBB2 ERBB3
9 MAP kinase kinase kinase activity GO:0004709 9.58 EGFR ERBB2 ERBB3
10 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.55 ESR1 FOXA1 GATA3 PGR TFAP2C
11 mitogen-activated protein kinase kinase binding GO:0031434 9.54 EGFR ERBB2 ERBB3
12 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 EGFR ERBB2 ERBB3
13 nitric-oxide synthase regulator activity GO:0030235 9.32 EGFR ESR1
14 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 EGFR ERBB2 ERBB3 ESR1
15 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.8 EGFR ERBB2 ERBB3
Sources

Sources for Luminal Breast Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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