MCID: LMN016
MIFTS: 28

Luminal Breast Carcinoma B

Categories: Cancer diseases

Aliases & Classifications for Luminal Breast Carcinoma B

MalaCards integrated aliases for Luminal Breast Carcinoma B:

Name: Luminal Breast Carcinoma B 12 15
Luminal B Breast Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080674
NCIt 50 C53555
UMLS 71 C3642346

Summaries for Luminal Breast Carcinoma B

Disease Ontology : 12 A breast carcinoma that is characterized by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (ER), and high expression of GGH, LAPTM4B, and CCNE1.

MalaCards based summary : Luminal Breast Carcinoma B, also known as luminal b breast carcinoma, is related to luminal breast carcinoma a and glassy cell carcinoma of the cervix. An important gene associated with Luminal Breast Carcinoma B is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2). Affiliated tissues include breast, and related phenotype is integument.

Related Diseases for Luminal Breast Carcinoma B

Diseases in the Luminal Breast Carcinoma a family:

Luminal Breast Carcinoma B

Diseases related to Luminal Breast Carcinoma B via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 luminal breast carcinoma a 10.2 ERBB2 DCHS2
2 glassy cell carcinoma of the cervix 10.0 PGR ERBB2
3 breast intraductal papillomatosis 10.0 PGR ERBB2
4 intraductal papilloma 10.0 PGR ERBB2
5 nipple carcinoma 10.0 PGR ERBB2
6 scirrhous adenocarcinoma 10.0 PGR ERBB2
7 lipid-rich breast carcinoma 10.0 PGR ERBB2
8 breast scirrhous carcinoma 10.0 PGR ERBB2
9 oncocytic breast carcinoma 10.0 PGR ERBB2
10 apocrine adenosis of breast 10.0 PGR ERBB2
11 breast papillary carcinoma 10.0 PGR ERBB2
12 comedo carcinoma 10.0 PGR ERBB2
13 breast adenoid cystic carcinoma 10.0 PGR ERBB2
14 breast metaplastic carcinoma 10.0 PGR ERBB2
15 breast mucinous carcinoma 10.0 PGR ERBB2
16 gastric diffuse adenocarcinoma 10.0 PGR ERBB2
17 lipid-rich carcinoma 10.0 PGR ERBB2
18 linitis plastica 10.0 PGR ERBB2
19 breast sarcoma 10.0 PGR ERBB2
20 breast malignant phyllodes tumor 10.0 PGR ERBB2
21 triple-receptor negative breast cancer 10.0 PGR ERBB2
22 progesterone-receptor negative breast cancer 10.0 PGR ERBB2
23 intracystic papillary adenoma 10.0 PGR ERBB2
24 breast osteosarcoma 10.0 PGR ERBB2
25 apocrine adenocarcinoma 10.0 PGR ERBB2
26 pyometritis 10.0 TBX3 PGR
27 breast neuroendocrine neoplasm 10.0 PGR ERBB2
28 breast papillomatosis 10.0 PGR ERBB2
29 synchronous bilateral breast carcinoma 10.0 PGR ERBB2
30 intraductal breast benign neoplasm 10.0 PGR ERBB2
31 breast benign neoplasm 10.0 PGR ERBB2
32 primary peritoneal carcinoma 10.0 PGR ERBB2
33 cribriform carcinoma 10.0 PGR ERBB2
34 progesterone-receptor positive breast cancer 10.0 PGR ERBB2
35 microglandular adenosis 10.0 PGR ERBB2
36 vulvar disease 10.0 PGR ERBB2
37 endometrial serous adenocarcinoma 10.0 PGR ERBB2
38 hypertrophy of breast 10.0 PGR ERBB2
39 retinitis pigmentosa 47 10.0 PGR ERBB2
40 female reproductive endometrioid cancer 10.0 PGR ERBB2
41 inflammatory breast carcinoma 10.0 PGR ERBB2
42 adenosarcoma 9.9 PGR ERBB2
43 mulchandani-bhoj-conlin syndrome 9.9 PGR ERBB2
44 endocervical carcinoma 9.9 PGR ERBB2
45 lobular neoplasia 9.9 PGR ERBB2
46 sweat gland cancer 9.9 PGR ERBB2
47 sweat gland disease 9.9 PGR ERBB2
48 thoracic benign neoplasm 9.9 PGR ERBB2
49 mixed cell type cancer 9.9 PGR ERBB2
50 short syndrome 9.9 PGR ERBB2

Graphical network of the top 20 diseases related to Luminal Breast Carcinoma B:



Diseases related to Luminal Breast Carcinoma B

Symptoms & Phenotypes for Luminal Breast Carcinoma B

MGI Mouse Phenotypes related to Luminal Breast Carcinoma B:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.1 ERBB2 FOXA1 MMP11 PDGFA PGR TBX3

Drugs & Therapeutics for Luminal Breast Carcinoma B

Search Clinical Trials , NIH Clinical Center for Luminal Breast Carcinoma B

Genetic Tests for Luminal Breast Carcinoma B

Anatomical Context for Luminal Breast Carcinoma B

MalaCards organs/tissues related to Luminal Breast Carcinoma B:

40
Breast

Publications for Luminal Breast Carcinoma B

Articles related to Luminal Breast Carcinoma B:

# Title Authors PMID Year
1
Analysis of the Gene Expression Profile of Stromal Pro-Tumor Factors in Cancer-Associated Fibroblasts from Luminal Breast Carcinomas. 61
33114046 2020
2
Comparison of visual assessment and image analysis in the evaluation of Ki-67 expression and their prognostic significance in immunohistochemically defined luminal breast carcinoma. 61
27511992 2016

Variations for Luminal Breast Carcinoma B

Cosmic variations for Luminal Breast Carcinoma B:

9 (show top 50) (show all 5031)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM137960127 ZNF598 breast,NS,carcinoma,ER-PR-positive carcinoma c.610G>A p.E204K 16:2002326-2002326 9
2 COSM135195220 ZNF598 breast,NS,carcinoma,ER-PR-positive carcinoma c.610G>A p.E204K 16:2002326-2002326 9
3 COSM99169942 YWHAQ breast,NS,carcinoma,ER-PR-positive carcinoma c.536A>G p.Y179C 2:9588211-9588211 9
4 COSM86351284 YWHAQ breast,NS,carcinoma,ER-PR-positive carcinoma c.536A>G p.Y179C 2:9588211-9588211 9
5 COSM143036457 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.918G>A p.M306I 11:102206008-102206008 9
6 COSM126968360 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.384G>A p.M128I 11:102206008-102206008 9
7 COSM127993455 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.918G>A p.M306I 11:102206008-102206008 9
8 COSM85231921 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.918G>A p.M306I 11:102206008-102206008 9
9 COSM133267649 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.918G>A p.M306I 11:102206008-102206008 9
10 COSM90942881 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.804G>A p.M268I 11:102206008-102206008 9
11 COSM145023383 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.804G>A p.M268I 11:102206008-102206008 9
12 COSM128447016 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.804G>A p.M268I 11:102206008-102206008 9
13 COSM105628484 XBP1 breast,NS,carcinoma,ER-positive carcinoma c.19G>A p.A7T 22:28800506-28800506 9
14 COSM85917792 XBP1 breast,NS,carcinoma,ER-positive carcinoma c.19G>A p.A7T 22:28800506-28800506 9
15 COSM142230116 XBP1 breast,NS,carcinoma,ER-positive carcinoma c.19G>A p.A7T 22:28800506-28800506 9
16 COSM89270241 XBP1 breast,NS,carcinoma,ER-positive carcinoma c.19G>A p.A7T 22:28800506-28800506 9
17 COSM85182140 WNT2 breast,NS,carcinoma,ER-PR-positive carcinoma c.321A>G p.E107= 7:117315338-117315338 9
18 COSM90882705 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 9
19 COSM128158629 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 9
20 COSM92018095 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 9
21 COSM130230128 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 9
22 COSM132341362 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 9
23 COSM88293154 VHL breast,NS,carcinoma,ER-positive carcinoma c.413C>T p.P138L 3:10146586-10146586 9
24 COSM90651104 VHL breast,NS,carcinoma,ER-positive carcinoma c.341-3273G>A p.? 3:10146514-10146514 9
25 COSM90653783 VHL breast,NS,carcinoma,ER-positive carcinoma c.341-3201C>T p.? 3:10146586-10146586 9
26 COSM88290785 VHL breast,NS,carcinoma,ER-positive carcinoma c.341G>A p.G114D 3:10146514-10146514 9
27 COSM140071241 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2103G>A p.K701= 19:6850739-6850739 9
28 COSM130163321 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2031G>A p.K677= 19:6850739-6850739 9
29 COSM141193936 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2034G>A p.K678= 19:6850739-6850739 9
30 COSM85972860 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2133G>A p.K711= 19:6850739-6850739 9
31 COSM142340805 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2199G>A p.K733= 19:6850739-6850739 9
32 COSM88837054 USP9X breast,NS,carcinoma,ER-PR-positive carcinoma c.3693A>T p.R1231S 23:41188000-41188000 9
33 COSM98536780 USP9X breast,NS,carcinoma,ER-PR-positive carcinoma c.3693A>T p.R1231S 23:41188000-41188000 9
34 COSM103478546 USP34 breast,NS,carcinoma,ER-PR-positive carcinoma c.4201C>A p.L1401I 2:61296853-61296853 9
35 COSM87092276 USP31 breast,NS,carcinoma,ER-PR-positive carcinoma c.721C>T p.H241Y 16:23108096-23108096 9
36 COSM93461611 USP16 breast,NS,carcinoma,ER-PR-positive carcinoma c.2344C>T p.P782S 21:29053952-29053952 9
37 COSM103742887 USP16 breast,NS,carcinoma,ER-PR-positive carcinoma c.2341C>T p.P781S 21:29053952-29053952 9
38 COSM103747829 USP16 breast,NS,carcinoma,ER-PR-positive carcinoma c.2344C>T p.P782S 21:29053952-29053952 9
39 COSM127063897 UBR5 breast,NS,carcinoma,ER-PR-positive carcinoma c.4392C>G p.F1464L 8:102293802-102293802 9
40 COSM127538052 UBR5 breast,NS,carcinoma,ER-PR-positive carcinoma c.4374C>G p.F1458L 8:102293802-102293802 9
41 COSM87429062 UBR5 breast,NS,carcinoma,ER-PR-positive carcinoma c.4392C>G p.F1464L 8:102293802-102293802 9
42 COSM144361724 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 9
43 COSM101929825 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1872C>T p.Y624= 15:25356787-25356787 9
44 COSM149764169 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1863C>T p.Y621= 15:25356787-25356787 9
45 COSM108914927 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 9
46 COSM107120943 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 9
47 COSM145837560 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 9
48 COSM135842312 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 9
49 COSM85309324 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 9
50 COSM143810042 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1863C>T p.Y621= 15:25356787-25356787 9

Expression for Luminal Breast Carcinoma B

Search GEO for disease gene expression data for Luminal Breast Carcinoma B.

Pathways for Luminal Breast Carcinoma B

GO Terms for Luminal Breast Carcinoma B

Biological processes related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 9.26 PDGFA ERBB2
2 lung alveolus development GO:0048286 9.16 PGR PDGFA
3 multicellular organism development GO:0007275 9.02 TBX3 PDGFA MMP11 FOXA1 ERBB2
4 mammary gland development GO:0030879 8.96 TBX3 PGR

Sources for Luminal Breast Carcinoma B

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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