Luminal Breast Carcinoma B disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Luminal Breast Carcinoma B

MalaCards integrated aliases for Luminal Breast Carcinoma B:

Name: Luminal Breast Carcinoma B ¹¹ ¹⁴

Luminal B Breast Carcinoma ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0080674

NCIt ⁴⁹ C53555

UMLS ⁷¹ C3642346

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Summaries for Luminal Breast Carcinoma B

Disease Ontology: ¹¹ A breast carcinoma that is characterized by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (ER), and high expression of GGH, LAPTM4B, and CCNE1.

MalaCards based summary: Luminal Breast Carcinoma B, also known as luminal b breast carcinoma, is related to familial episodic pain syndrome and breast lobular carcinoma. An important gene associated with Luminal Breast Carcinoma B is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are CREB Pathway and Ion channel transport. Affiliated tissues include breast, and related phenotype is limbs/digits/tail.

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Related Diseases for Luminal Breast Carcinoma B

Diseases in the Luminal Breast Carcinoma a family:

Luminal Breast Carcinoma B

Diseases related to Luminal Breast Carcinoma B via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	familial episodic pain syndrome	10.0	TRPM4 TRPM3
2	breast lobular carcinoma	9.9	TBX3 ERBB2
3	progressive familial heart block	9.9	TRPM6 TRPM4
4	mucolipidosis iv	9.8	TRPM6 TRPM3
5	mutilating palmoplantar keratoderma with periorificial keratotic plaques	9.8	TRPM6 TRPM4 TRPM3
6	autosomal dominant polycystic kidney disease	9.7	TRPM6 TRPM4 TRPM3

Graphical network of the top 20 diseases related to Luminal Breast Carcinoma B:

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Symptoms & Phenotypes for Luminal Breast Carcinoma B

MGI Mouse Phenotypes related to Luminal Breast Carcinoma B:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail	MP:0005371	8.92	ERBB2 IL31 MMP11 TBX3

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Drugs & Therapeutics for Luminal Breast Carcinoma B

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phi29 Motor Nanopore for Single Molecule Sensing: Breast Nipple Aspirate Fluid	Recruiting	NCT03715959

Search NIH Clinical Center for Luminal Breast Carcinoma B

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Genetic Tests for Luminal Breast Carcinoma B

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Anatomical Context for Luminal Breast Carcinoma B

Organs/tissues related to Luminal Breast Carcinoma B:

MalaCards : Breast

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Publications for Luminal Breast Carcinoma B

Articles related to Luminal Breast Carcinoma B:

#	Title	Authors	PMID	Year
1	Analysis of the Gene Expression Profile of Stromal Pro-Tumor Factors in Cancer-Associated Fibroblasts from Luminal Breast Carcinomas. ⁶²	Eiro N...Vizoso FJ	33114046	2020
2	Comparison of visual assessment and image analysis in the evaluation of Ki-67 expression and their prognostic significance in immunohistochemically defined luminal breast carcinoma. ⁶²	Arihiro K...Kobayashi Y	27511992	2016

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Genes for Luminal Breast Carcinoma B

Genes related to Luminal Breast Carcinoma B (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	4.98	DISEASES inferred ¹⁴
2	TRPM3	Transient Receptor Potential Cation Channel Subfamily M Member 3	Protein Coding	4.61	DISEASES inferred ¹⁴
3	TBX3	T-Box Transcription Factor 3	Protein Coding	4.58	DISEASES inferred ¹⁴
4	TRPM6	Transient Receptor Potential Cation Channel Subfamily M Member 6	Protein Coding	4.5	DISEASES inferred ¹⁴
5	TRPM4	Transient Receptor Potential Cation Channel Subfamily M Member 4	Protein Coding	4.39	DISEASES inferred ¹⁴
6	DCHS2	Dachsous Cadherin-Related 2	Protein Coding	4.34	DISEASES inferred ¹⁴
7	MMP11	Matrix Metallopeptidase 11	Protein Coding	4.16	DISEASES inferred ¹⁴
8	POTED	POTE Ankyrin Domain Family Member D	Protein Coding	4.05	DISEASES inferred ¹⁴
9	IL31	Interleukin 31	Protein Coding	3.99	DISEASES inferred ¹⁴

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Variations for Luminal Breast Carcinoma B

Cosmic variations for Luminal Breast Carcinoma B:

⁸ (show top 50) (show all 5031)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM137960127	ZNF598	breast,NS,carcinoma,ER-PR-positive carcinoma	c.610G>A	p.E204K	16:2002326-2002326	7
2	COSM135195220	ZNF598	breast,NS,carcinoma,ER-PR-positive carcinoma	c.610G>A	p.E204K	16:2002326-2002326	7
3	COSM99169942	YWHAQ	breast,NS,carcinoma,ER-PR-positive carcinoma	c.536A>G	p.Y179C	2:9588211-9588211	7
4	COSM86351284	YWHAQ	breast,NS,carcinoma,ER-PR-positive carcinoma	c.536A>G	p.Y179C	2:9588211-9588211	7
5	COSM143036457	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.918G>A	p.M306I	11:102206008-102206008	7
6	COSM126968360	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.384G>A	p.M128I	11:102206008-102206008	7
7	COSM127993455	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.918G>A	p.M306I	11:102206008-102206008	7
8	COSM85231921	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.918G>A	p.M306I	11:102206008-102206008	7
9	COSM133267649	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.918G>A	p.M306I	11:102206008-102206008	7
10	COSM90942881	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.804G>A	p.M268I	11:102206008-102206008	7
11	COSM145023383	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.804G>A	p.M268I	11:102206008-102206008	7
12	COSM128447016	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.804G>A	p.M268I	11:102206008-102206008	7
13	COSM105628484	XBP1	breast,NS,carcinoma,ER-positive carcinoma	c.19G>A	p.A7T	22:28800506-28800506	7
14	COSM85917792	XBP1	breast,NS,carcinoma,ER-positive carcinoma	c.19G>A	p.A7T	22:28800506-28800506	7
15	COSM142230116	XBP1	breast,NS,carcinoma,ER-positive carcinoma	c.19G>A	p.A7T	22:28800506-28800506	7
16	COSM89270241	XBP1	breast,NS,carcinoma,ER-positive carcinoma	c.19G>A	p.A7T	22:28800506-28800506	7
17	COSM85182140	WNT2	breast,NS,carcinoma,ER-PR-positive carcinoma	c.321A>G	p.E107=	7:117315338-117315338	7
18	COSM90882705	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	7
19	COSM128158629	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	7
20	COSM92018095	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	7
21	COSM130230128	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	7
22	COSM132341362	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	7
23	COSM88293154	VHL	breast,NS,carcinoma,ER-positive carcinoma	c.413C>T	p.P138L	3:10146586-10146586	7
24	COSM90651104	VHL	breast,NS,carcinoma,ER-positive carcinoma	c.341-3273G>A	p.?	3:10146514-10146514	7
25	COSM90653783	VHL	breast,NS,carcinoma,ER-positive carcinoma	c.341-3201C>T	p.?	3:10146586-10146586	7
26	COSM88290785	VHL	breast,NS,carcinoma,ER-positive carcinoma	c.341G>A	p.G114D	3:10146514-10146514	7
27	COSM140071241	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2103G>A	p.K701=	19:6850739-6850739	7
28	COSM130163321	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2031G>A	p.K677=	19:6850739-6850739	7
29	COSM141193936	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2034G>A	p.K678=	19:6850739-6850739	7
30	COSM85972860	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2133G>A	p.K711=	19:6850739-6850739	7
31	COSM142340805	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2199G>A	p.K733=	19:6850739-6850739	7
32	COSM88837054	USP9X	breast,NS,carcinoma,ER-PR-positive carcinoma	c.3693A>T	p.R1231S	23:41188000-41188000	7
33	COSM98536780	USP9X	breast,NS,carcinoma,ER-PR-positive carcinoma	c.3693A>T	p.R1231S	23:41188000-41188000	7
34	COSM103478546	USP34	breast,NS,carcinoma,ER-PR-positive carcinoma	c.4201C>A	p.L1401I	2:61296853-61296853	7
35	COSM87092276	USP31	breast,NS,carcinoma,ER-PR-positive carcinoma	c.721C>T	p.H241Y	16:23108096-23108096	7
36	COSM93461611	USP16	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2344C>T	p.P782S	21:29053952-29053952	7
37	COSM103742887	USP16	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2341C>T	p.P781S	21:29053952-29053952	7
38	COSM103747829	USP16	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2344C>T	p.P782S	21:29053952-29053952	7
39	COSM116184328	UQCC5	breast,NS,carcinoma,ER-positive carcinoma	c.*114G>C	p.?	3:52579160-52579160	7
40	COSM127063897	UBR5	breast,NS,carcinoma,ER-PR-positive carcinoma	c.4392C>G	p.F1464L	8:102293802-102293802	7
41	COSM127538052	UBR5	breast,NS,carcinoma,ER-PR-positive carcinoma	c.4374C>G	p.F1458L	8:102293802-102293802	7
42	COSM87429062	UBR5	breast,NS,carcinoma,ER-PR-positive carcinoma	c.4392C>G	p.F1464L	8:102293802-102293802	7
43	COSM144361724	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	7
44	COSM101929825	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1872C>T	p.Y624=	15:25356787-25356787	7
45	COSM149764169	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1863C>T	p.Y621=	15:25356787-25356787	7
46	COSM108914927	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	7
47	COSM107120943	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	7
48	COSM145837560	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	7
49	COSM135842312	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	7
50	COSM85309324	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	7

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Expression for Luminal Breast Carcinoma B

Search GEO for disease gene expression data for Luminal Breast Carcinoma B.

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Pathways for Luminal Breast Carcinoma B

Pathways related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	12.54	TRPM6 TRPM4 TRPM3 ERBB2
2	Ion channel transport ⁶⁶ Show member pathways Stimuli-sensing channels ⁶⁶	11.6	TRPM6 TRPM4 TRPM3
3	TRP channels ⁶⁶	10.25	TRPM6 TRPM4 TRPM3

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GO Terms for Luminal Breast Carcinoma B

Cellular components related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	obsolete spanning component of plasma membrane	GO:0044214	8.62	TRPM4 ERBB2

Biological processes related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium ion transmembrane transport	GO:0070588	9.8	TRPM6 TRPM4 TRPM3
2	protein tetramerization	GO:0051262	9.67	TRPM6 TRPM3
3	monoatomic cation transmembrane transport	GO:0098655	9.63	TRPM6 TRPM4 TRPM3
4	monoatomic ion transmembrane transport	GO:0034220	9.58	TRPM6 TRPM4 TRPM3
5	calcium ion transport	GO:0006816	9.43	TRPM6 TRPM4 TRPM3
6	monoatomic cation transport	GO:0006812	9.26	TRPM6 TRPM4 TRPM3
7	metal ion transport	GO:0030001	8.8	TRPM6 TRPM4 TRPM3

Molecular functions related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium activated cation channel activity	GO:0005227	9.56	TRPM4 TRPM3
2	calcium channel activity	GO:0005262	9.35	TRPM6 TRPM4 TRPM3
3	monoatomic ion channel activity	GO:0005216	9.33	TRPM6 TRPM4 TRPM3
4	monoatomic cation channel activity	GO:0005261	9.1	TRPM6 TRPM4 TRPM3

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Sources for Luminal Breast Carcinoma B

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LMN016 MIFTS: 29	Luminal Breast Carcinoma B Categories: Cancer diseases	Data Licensing For inquiries, contact: [email protected]
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