MCID: LMN016
MIFTS: 29

Luminal Breast Carcinoma B

Categories: Cancer diseases
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Aliases & Classifications for Luminal Breast Carcinoma B

MalaCards integrated aliases for Luminal Breast Carcinoma B:

Name: Luminal Breast Carcinoma B 11 14
Luminal B Breast Carcinoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:0080674
NCIt 49 C53555
UMLS 71 C3642346

Summaries for Luminal Breast Carcinoma B

Disease Ontology: 11 A breast carcinoma that is characterized by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (ER), and high expression of GGH, LAPTM4B, and CCNE1.

MalaCards based summary: Luminal Breast Carcinoma B, also known as luminal b breast carcinoma, is related to familial episodic pain syndrome and breast lobular carcinoma. An important gene associated with Luminal Breast Carcinoma B is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are CREB Pathway and Ion channel transport. Affiliated tissues include breast, and related phenotype is limbs/digits/tail.

Related Diseases for Luminal Breast Carcinoma B

Diseases in the Luminal Breast Carcinoma a family:

Luminal Breast Carcinoma B

Diseases related to Luminal Breast Carcinoma B via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 familial episodic pain syndrome 10.0 TRPM4 TRPM3
2 breast lobular carcinoma 9.9 TBX3 ERBB2
3 progressive familial heart block 9.9 TRPM6 TRPM4
4 mucolipidosis iv 9.8 TRPM6 TRPM3
5 mutilating palmoplantar keratoderma with periorificial keratotic plaques 9.8 TRPM6 TRPM4 TRPM3
6 autosomal dominant polycystic kidney disease 9.7 TRPM6 TRPM4 TRPM3

Graphical network of the top 20 diseases related to Luminal Breast Carcinoma B:



Diseases related to Luminal Breast Carcinoma B

Symptoms & Phenotypes for Luminal Breast Carcinoma B

MGI Mouse Phenotypes related to Luminal Breast Carcinoma B:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 ERBB2 IL31 MMP11 TBX3

Drugs & Therapeutics for Luminal Breast Carcinoma B

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phi29 Motor Nanopore for Single Molecule Sensing: Breast Nipple Aspirate Fluid Recruiting NCT03715959

Search NIH Clinical Center for Luminal Breast Carcinoma B

Genetic Tests for Luminal Breast Carcinoma B

Anatomical Context for Luminal Breast Carcinoma B

Organs/tissues related to Luminal Breast Carcinoma B:

MalaCards : Breast

Publications for Luminal Breast Carcinoma B

Articles related to Luminal Breast Carcinoma B:

# Title Authors PMID Year
1
Analysis of the Gene Expression Profile of Stromal Pro-Tumor Factors in Cancer-Associated Fibroblasts from Luminal Breast Carcinomas. 62
33114046 2020
2
Comparison of visual assessment and image analysis in the evaluation of Ki-67 expression and their prognostic significance in immunohistochemically defined luminal breast carcinoma. 62
27511992 2016

Variations for Luminal Breast Carcinoma B

Cosmic variations for Luminal Breast Carcinoma B:

8 (show top 50) (show all 5031)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM137960127 ZNF598 breast,NS,carcinoma,ER-PR-positive carcinoma c.610G>A p.E204K 16:2002326-2002326 7
2 COSM135195220 ZNF598 breast,NS,carcinoma,ER-PR-positive carcinoma c.610G>A p.E204K 16:2002326-2002326 7
3 COSM99169942 YWHAQ breast,NS,carcinoma,ER-PR-positive carcinoma c.536A>G p.Y179C 2:9588211-9588211 7
4 COSM86351284 YWHAQ breast,NS,carcinoma,ER-PR-positive carcinoma c.536A>G p.Y179C 2:9588211-9588211 7
5 COSM143036457 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.918G>A p.M306I 11:102206008-102206008 7
6 COSM126968360 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.384G>A p.M128I 11:102206008-102206008 7
7 COSM127993455 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.918G>A p.M306I 11:102206008-102206008 7
8 COSM85231921 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.918G>A p.M306I 11:102206008-102206008 7
9 COSM133267649 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.918G>A p.M306I 11:102206008-102206008 7
10 COSM90942881 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.804G>A p.M268I 11:102206008-102206008 7
11 COSM145023383 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.804G>A p.M268I 11:102206008-102206008 7
12 COSM128447016 YAP1 breast,NS,carcinoma,ER-positive carcinoma c.804G>A p.M268I 11:102206008-102206008 7
13 COSM105628484 XBP1 breast,NS,carcinoma,ER-positive carcinoma c.19G>A p.A7T 22:28800506-28800506 7
14 COSM85917792 XBP1 breast,NS,carcinoma,ER-positive carcinoma c.19G>A p.A7T 22:28800506-28800506 7
15 COSM142230116 XBP1 breast,NS,carcinoma,ER-positive carcinoma c.19G>A p.A7T 22:28800506-28800506 7
16 COSM89270241 XBP1 breast,NS,carcinoma,ER-positive carcinoma c.19G>A p.A7T 22:28800506-28800506 7
17 COSM85182140 WNT2 breast,NS,carcinoma,ER-PR-positive carcinoma c.321A>G p.E107= 7:117315338-117315338 7
18 COSM90882705 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 7
19 COSM128158629 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 7
20 COSM92018095 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 7
21 COSM130230128 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 7
22 COSM132341362 WNK1 breast,NS,carcinoma,ER-PR-positive carcinoma c.1490A>G p.K497R 12:859334-859334 7
23 COSM88293154 VHL breast,NS,carcinoma,ER-positive carcinoma c.413C>T p.P138L 3:10146586-10146586 7
24 COSM90651104 VHL breast,NS,carcinoma,ER-positive carcinoma c.341-3273G>A p.? 3:10146514-10146514 7
25 COSM90653783 VHL breast,NS,carcinoma,ER-positive carcinoma c.341-3201C>T p.? 3:10146586-10146586 7
26 COSM88290785 VHL breast,NS,carcinoma,ER-positive carcinoma c.341G>A p.G114D 3:10146514-10146514 7
27 COSM140071241 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2103G>A p.K701= 19:6850739-6850739 7
28 COSM130163321 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2031G>A p.K677= 19:6850739-6850739 7
29 COSM141193936 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2034G>A p.K678= 19:6850739-6850739 7
30 COSM85972860 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2133G>A p.K711= 19:6850739-6850739 7
31 COSM142340805 VAV1 breast,NS,carcinoma,ER-PR-positive carcinoma c.2199G>A p.K733= 19:6850739-6850739 7
32 COSM88837054 USP9X breast,NS,carcinoma,ER-PR-positive carcinoma c.3693A>T p.R1231S 23:41188000-41188000 7
33 COSM98536780 USP9X breast,NS,carcinoma,ER-PR-positive carcinoma c.3693A>T p.R1231S 23:41188000-41188000 7
34 COSM103478546 USP34 breast,NS,carcinoma,ER-PR-positive carcinoma c.4201C>A p.L1401I 2:61296853-61296853 7
35 COSM87092276 USP31 breast,NS,carcinoma,ER-PR-positive carcinoma c.721C>T p.H241Y 16:23108096-23108096 7
36 COSM93461611 USP16 breast,NS,carcinoma,ER-PR-positive carcinoma c.2344C>T p.P782S 21:29053952-29053952 7
37 COSM103742887 USP16 breast,NS,carcinoma,ER-PR-positive carcinoma c.2341C>T p.P781S 21:29053952-29053952 7
38 COSM103747829 USP16 breast,NS,carcinoma,ER-PR-positive carcinoma c.2344C>T p.P782S 21:29053952-29053952 7
39 COSM116184328 UQCC5 breast,NS,carcinoma,ER-positive carcinoma c.*114G>C p.? 3:52579160-52579160 7
40 COSM127063897 UBR5 breast,NS,carcinoma,ER-PR-positive carcinoma c.4392C>G p.F1464L 8:102293802-102293802 7
41 COSM127538052 UBR5 breast,NS,carcinoma,ER-PR-positive carcinoma c.4374C>G p.F1458L 8:102293802-102293802 7
42 COSM87429062 UBR5 breast,NS,carcinoma,ER-PR-positive carcinoma c.4392C>G p.F1464L 8:102293802-102293802 7
43 COSM144361724 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 7
44 COSM101929825 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1872C>T p.Y624= 15:25356787-25356787 7
45 COSM149764169 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1863C>T p.Y621= 15:25356787-25356787 7
46 COSM108914927 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 7
47 COSM107120943 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 7
48 COSM145837560 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 7
49 COSM135842312 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 7
50 COSM85309324 UBE3A breast,NS,carcinoma,ER-PR-positive carcinoma c.1803C>T p.Y601= 15:25356787-25356787 7

Expression for Luminal Breast Carcinoma B

Search GEO for disease gene expression data for Luminal Breast Carcinoma B.

Pathways for Luminal Breast Carcinoma B

Pathways related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 TRPM6 TRPM4 TRPM3 ERBB2
2
Show member pathways
11.6 TRPM6 TRPM4 TRPM3
3 10.25 TRPM6 TRPM4 TRPM3

GO Terms for Luminal Breast Carcinoma B

Cellular components related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete spanning component of plasma membrane GO:0044214 8.62 TRPM4 ERBB2

Biological processes related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion transmembrane transport GO:0070588 9.8 TRPM6 TRPM4 TRPM3
2 protein tetramerization GO:0051262 9.67 TRPM6 TRPM3
3 monoatomic cation transmembrane transport GO:0098655 9.63 TRPM6 TRPM4 TRPM3
4 monoatomic ion transmembrane transport GO:0034220 9.58 TRPM6 TRPM4 TRPM3
5 calcium ion transport GO:0006816 9.43 TRPM6 TRPM4 TRPM3
6 monoatomic cation transport GO:0006812 9.26 TRPM6 TRPM4 TRPM3
7 metal ion transport GO:0030001 8.8 TRPM6 TRPM4 TRPM3

Molecular functions related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium activated cation channel activity GO:0005227 9.56 TRPM4 TRPM3
2 calcium channel activity GO:0005262 9.35 TRPM6 TRPM4 TRPM3
3 monoatomic ion channel activity GO:0005216 9.33 TRPM6 TRPM4 TRPM3
4 monoatomic cation channel activity GO:0005261 9.1 TRPM6 TRPM4 TRPM3

Sources for Luminal Breast Carcinoma B

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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