Luminal Breast Carcinoma B disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LMN016 MIFTS: 28	Luminal Breast Carcinoma B Categories: Cancer diseases
Genes Variations Tissues Related diseases Publications Expand all tables

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Aliases & Classifications for Luminal Breast Carcinoma B

MalaCards integrated aliases for Luminal Breast Carcinoma B:

Name: Luminal Breast Carcinoma B ¹² ¹⁵

Luminal B Breast Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080674

NCIt ⁵⁰ C53555

UMLS ⁷¹ C3642346

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Summaries for Luminal Breast Carcinoma B

Disease Ontology : ¹² A breast carcinoma that is characterized by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (ER), and high expression of GGH, LAPTM4B, and CCNE1.

MalaCards based summary : Luminal Breast Carcinoma B, also known as luminal b breast carcinoma, is related to luminal breast carcinoma a and glassy cell carcinoma of the cervix. An important gene associated with Luminal Breast Carcinoma B is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2). Affiliated tissues include breast, and related phenotype is integument.

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Related Diseases for Luminal Breast Carcinoma B

Diseases in the Luminal Breast Carcinoma a family:

Luminal Breast Carcinoma B

Diseases related to Luminal Breast Carcinoma B via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)

#	Related Disease	Score	Top Affiliating Genes
1	luminal breast carcinoma a	10.2	ERBB2 DCHS2
2	glassy cell carcinoma of the cervix	10.0	PGR ERBB2
3	breast intraductal papillomatosis	10.0	PGR ERBB2
4	intraductal papilloma	10.0	PGR ERBB2
5	nipple carcinoma	10.0	PGR ERBB2
6	scirrhous adenocarcinoma	10.0	PGR ERBB2
7	lipid-rich breast carcinoma	10.0	PGR ERBB2
8	breast scirrhous carcinoma	10.0	PGR ERBB2
9	oncocytic breast carcinoma	10.0	PGR ERBB2
10	apocrine adenosis of breast	10.0	PGR ERBB2
11	breast papillary carcinoma	10.0	PGR ERBB2
12	comedo carcinoma	10.0	PGR ERBB2
13	breast adenoid cystic carcinoma	10.0	PGR ERBB2
14	breast metaplastic carcinoma	10.0	PGR ERBB2
15	breast mucinous carcinoma	10.0	PGR ERBB2
16	gastric diffuse adenocarcinoma	10.0	PGR ERBB2
17	lipid-rich carcinoma	10.0	PGR ERBB2
18	linitis plastica	10.0	PGR ERBB2
19	breast sarcoma	10.0	PGR ERBB2
20	breast malignant phyllodes tumor	10.0	PGR ERBB2
21	triple-receptor negative breast cancer	10.0	PGR ERBB2
22	progesterone-receptor negative breast cancer	10.0	PGR ERBB2
23	intracystic papillary adenoma	10.0	PGR ERBB2
24	breast osteosarcoma	10.0	PGR ERBB2
25	apocrine adenocarcinoma	10.0	PGR ERBB2
26	pyometritis	10.0	TBX3 PGR
27	breast neuroendocrine neoplasm	10.0	PGR ERBB2
28	breast papillomatosis	10.0	PGR ERBB2
29	synchronous bilateral breast carcinoma	10.0	PGR ERBB2
30	intraductal breast benign neoplasm	10.0	PGR ERBB2
31	breast benign neoplasm	10.0	PGR ERBB2
32	primary peritoneal carcinoma	10.0	PGR ERBB2
33	cribriform carcinoma	10.0	PGR ERBB2
34	progesterone-receptor positive breast cancer	10.0	PGR ERBB2
35	microglandular adenosis	10.0	PGR ERBB2
36	vulvar disease	10.0	PGR ERBB2
37	endometrial serous adenocarcinoma	10.0	PGR ERBB2
38	hypertrophy of breast	10.0	PGR ERBB2
39	retinitis pigmentosa 47	10.0	PGR ERBB2
40	female reproductive endometrioid cancer	10.0	PGR ERBB2
41	inflammatory breast carcinoma	10.0	PGR ERBB2
42	adenosarcoma	9.9	PGR ERBB2
43	mulchandani-bhoj-conlin syndrome	9.9	PGR ERBB2
44	endocervical carcinoma	9.9	PGR ERBB2
45	lobular neoplasia	9.9	PGR ERBB2
46	sweat gland cancer	9.9	PGR ERBB2
47	sweat gland disease	9.9	PGR ERBB2
48	thoracic benign neoplasm	9.9	PGR ERBB2
49	mixed cell type cancer	9.9	PGR ERBB2
50	short syndrome	9.9	PGR ERBB2

Graphical network of the top 20 diseases related to Luminal Breast Carcinoma B:

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Symptoms & Phenotypes for Luminal Breast Carcinoma B

MGI Mouse Phenotypes related to Luminal Breast Carcinoma B:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.1	ERBB2 FOXA1 MMP11 PDGFA PGR TBX3

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Drugs & Therapeutics for Luminal Breast Carcinoma B

Search Clinical Trials , NIH Clinical Center for Luminal Breast Carcinoma B

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Genetic Tests for Luminal Breast Carcinoma B

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Anatomical Context for Luminal Breast Carcinoma B

MalaCards organs/tissues related to Luminal Breast Carcinoma B:

⁴⁰

Breast

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Publications for Luminal Breast Carcinoma B

Articles related to Luminal Breast Carcinoma B:

#	Title	Authors	PMID	Year
1	Analysis of the Gene Expression Profile of Stromal Pro-Tumor Factors in Cancer-Associated Fibroblasts from Luminal Breast Carcinomas. ⁶¹	Eiro N...Vizoso FJ	33114046	2020
2	Comparison of visual assessment and image analysis in the evaluation of Ki-67 expression and their prognostic significance in immunohistochemically defined luminal breast carcinoma. ⁶¹	Arihiro K...Kobayashi Y	27511992	2016

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Genes for Luminal Breast Carcinoma B

Genes related to Luminal Breast Carcinoma B (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	5.2	DISEASES inferred ¹⁵
2	TBX3	T-Box Transcription Factor 3	Protein Coding	5.1	DISEASES inferred ¹⁵
3	DCHS2	Dachsous Cadherin-Related 2	Protein Coding	4.99	DISEASES inferred ¹⁵
4	MMP11	Matrix Metallopeptidase 11	Protein Coding	4.69	DISEASES inferred ¹⁵
5	FOXA1	Forkhead Box A1	Protein Coding	4.55	DISEASES inferred ¹⁵
6	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	4.53	DISEASES inferred ¹⁵
7	FBXW2	F-Box And WD Repeat Domain Containing 2	Protein Coding	4.46	DISEASES inferred ¹⁵
8	PGR	Progesterone Receptor	Protein Coding	4.34	DISEASES inferred ¹⁵
9	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	4.32	DISEASES inferred ¹⁵

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Variations for Luminal Breast Carcinoma B

Cosmic variations for Luminal Breast Carcinoma B:

⁹ (show top 50) (show all 5031)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM137960127	ZNF598	breast,NS,carcinoma,ER-PR-positive carcinoma	c.610G>A	p.E204K	16:2002326-2002326	9
2	COSM135195220	ZNF598	breast,NS,carcinoma,ER-PR-positive carcinoma	c.610G>A	p.E204K	16:2002326-2002326	9
3	COSM99169942	YWHAQ	breast,NS,carcinoma,ER-PR-positive carcinoma	c.536A>G	p.Y179C	2:9588211-9588211	9
4	COSM86351284	YWHAQ	breast,NS,carcinoma,ER-PR-positive carcinoma	c.536A>G	p.Y179C	2:9588211-9588211	9
5	COSM143036457	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.918G>A	p.M306I	11:102206008-102206008	9
6	COSM126968360	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.384G>A	p.M128I	11:102206008-102206008	9
7	COSM127993455	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.918G>A	p.M306I	11:102206008-102206008	9
8	COSM85231921	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.918G>A	p.M306I	11:102206008-102206008	9
9	COSM133267649	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.918G>A	p.M306I	11:102206008-102206008	9
10	COSM90942881	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.804G>A	p.M268I	11:102206008-102206008	9
11	COSM145023383	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.804G>A	p.M268I	11:102206008-102206008	9
12	COSM128447016	YAP1	breast,NS,carcinoma,ER-positive carcinoma	c.804G>A	p.M268I	11:102206008-102206008	9
13	COSM105628484	XBP1	breast,NS,carcinoma,ER-positive carcinoma	c.19G>A	p.A7T	22:28800506-28800506	9
14	COSM85917792	XBP1	breast,NS,carcinoma,ER-positive carcinoma	c.19G>A	p.A7T	22:28800506-28800506	9
15	COSM142230116	XBP1	breast,NS,carcinoma,ER-positive carcinoma	c.19G>A	p.A7T	22:28800506-28800506	9
16	COSM89270241	XBP1	breast,NS,carcinoma,ER-positive carcinoma	c.19G>A	p.A7T	22:28800506-28800506	9
17	COSM85182140	WNT2	breast,NS,carcinoma,ER-PR-positive carcinoma	c.321A>G	p.E107=	7:117315338-117315338	9
18	COSM90882705	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	9
19	COSM128158629	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	9
20	COSM92018095	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	9
21	COSM130230128	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	9
22	COSM132341362	WNK1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1490A>G	p.K497R	12:859334-859334	9
23	COSM88293154	VHL	breast,NS,carcinoma,ER-positive carcinoma	c.413C>T	p.P138L	3:10146586-10146586	9
24	COSM90651104	VHL	breast,NS,carcinoma,ER-positive carcinoma	c.341-3273G>A	p.?	3:10146514-10146514	9
25	COSM90653783	VHL	breast,NS,carcinoma,ER-positive carcinoma	c.341-3201C>T	p.?	3:10146586-10146586	9
26	COSM88290785	VHL	breast,NS,carcinoma,ER-positive carcinoma	c.341G>A	p.G114D	3:10146514-10146514	9
27	COSM140071241	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2103G>A	p.K701=	19:6850739-6850739	9
28	COSM130163321	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2031G>A	p.K677=	19:6850739-6850739	9
29	COSM141193936	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2034G>A	p.K678=	19:6850739-6850739	9
30	COSM85972860	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2133G>A	p.K711=	19:6850739-6850739	9
31	COSM142340805	VAV1	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2199G>A	p.K733=	19:6850739-6850739	9
32	COSM88837054	USP9X	breast,NS,carcinoma,ER-PR-positive carcinoma	c.3693A>T	p.R1231S	23:41188000-41188000	9
33	COSM98536780	USP9X	breast,NS,carcinoma,ER-PR-positive carcinoma	c.3693A>T	p.R1231S	23:41188000-41188000	9
34	COSM103478546	USP34	breast,NS,carcinoma,ER-PR-positive carcinoma	c.4201C>A	p.L1401I	2:61296853-61296853	9
35	COSM87092276	USP31	breast,NS,carcinoma,ER-PR-positive carcinoma	c.721C>T	p.H241Y	16:23108096-23108096	9
36	COSM93461611	USP16	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2344C>T	p.P782S	21:29053952-29053952	9
37	COSM103742887	USP16	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2341C>T	p.P781S	21:29053952-29053952	9
38	COSM103747829	USP16	breast,NS,carcinoma,ER-PR-positive carcinoma	c.2344C>T	p.P782S	21:29053952-29053952	9
39	COSM127063897	UBR5	breast,NS,carcinoma,ER-PR-positive carcinoma	c.4392C>G	p.F1464L	8:102293802-102293802	9
40	COSM127538052	UBR5	breast,NS,carcinoma,ER-PR-positive carcinoma	c.4374C>G	p.F1458L	8:102293802-102293802	9
41	COSM87429062	UBR5	breast,NS,carcinoma,ER-PR-positive carcinoma	c.4392C>G	p.F1464L	8:102293802-102293802	9
42	COSM144361724	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	9
43	COSM101929825	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1872C>T	p.Y624=	15:25356787-25356787	9
44	COSM149764169	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1863C>T	p.Y621=	15:25356787-25356787	9
45	COSM108914927	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	9
46	COSM107120943	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	9
47	COSM145837560	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	9
48	COSM135842312	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	9
49	COSM85309324	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1803C>T	p.Y601=	15:25356787-25356787	9
50	COSM143810042	UBE3A	breast,NS,carcinoma,ER-PR-positive carcinoma	c.1863C>T	p.Y621=	15:25356787-25356787	9

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Expression for Luminal Breast Carcinoma B

Search GEO for disease gene expression data for Luminal Breast Carcinoma B.

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Pathways for Luminal Breast Carcinoma B

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GO Terms for Luminal Breast Carcinoma B

Biological processes related to Luminal Breast Carcinoma B according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of MAP kinase activity	GO:0043406	9.26	PDGFA ERBB2
2	lung alveolus development	GO:0048286	9.16	PGR PDGFA
3	multicellular organism development	GO:0007275	9.02	TBX3 PDGFA MMP11 FOXA1 ERBB2
4	mammary gland development	GO:0030879	8.96	TBX3 PGR

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Sources for Luminal Breast Carcinoma B

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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¹⁰ dbSNP

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¹⁶ DrugBank

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¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

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⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia