Lung Abscess disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A lung disease characterized by microbial infection which causes a type of liquefactive necrosis of the pulmonary tissue and formation of cavities containing necrotic debris or fluid.

MalaCards based summary: Lung Abscess, also known as multiple abscess of lung, is related to pleural empyema and aspergillosis, and has symptoms including hemoptysis An important gene associated with Lung Abscess is LACTB (Lactamase Beta), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Ampicillin and Sulbactam have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and brain, and related phenotypes are digestive/alimentary and immune system

Wikipedia: ⁷⁵ Lung abscess is a type of liquefactive necrosis of the lung tissue and formation of cavities (more than... more...

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Related Diseases for Lung Abscess

Diseases related to Lung Abscess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1048)

#	Related Disease	Score	Top Affiliating Genes
1	pleural empyema	31.7	IL6 GPT CRP CD4 ALB
2	aspergillosis	31.3	TNF IL6 IL1B IFNG
3	aspiration pneumonia	30.6	TNF LACTB IL6 IL1B GPT CRP
4	intracranial abscess	30.4	LACTB CRP CD4
5	klebsiella pneumonia	30.3	LACTB GPT CRP ALB
6	hyper ige recurrent infection syndrome 1	30.3	IL6 DOCK8 CD4
7	nocardiosis	30.3	TNF CRP CD4
8	actinomycosis	30.3	TNF CRP CD4 ALB
9	echinococcosis	30.3	TNF IL6 IFNG
10	allergic bronchopulmonary aspergillosis	30.2	IGES IFNG CD4
11	infective endocarditis	30.2	IL6 CRP ALB
12	melioidosis	30.2	TNF IL6 IFNG
13	acute kidney failure	30.2	IL6 GPT ALB
14	nutritional deficiency disease	30.1	IL6 CRP ALB
15	croup	30.1	IL6 CRP CD4
16	haemophilus influenzae	30.1	TNF LACTB IL1B
17	legionnaire disease	30.1	TNF IL6 IL1B CRP CD4
18	enterocolitis	30.0	TNF IL6 CRP
19	disseminated intravascular coagulation	30.0	TNF IL6 GPT CRP
20	spontaneous tension pneumothorax	30.0	GPT CRP
21	inappropriate adh syndrome	30.0	IL6 CRP ALB
22	discitis	30.0	CRP ALB
23	anemia, autoimmune hemolytic	29.9	IL6 CRP CD4
24	adult syndrome	29.9	TNF IL6 CRP
25	endocarditis	29.9	TNF LACTB IL6 IFNG CRP ALB
26	diabetes mellitus, ketosis-prone	29.9	GPT CRP ALB
27	bronchiectasis	29.9	TNF IL6 IL1B IFNG CRP ALB
28	ascaris lumbricoides infection	29.8	GPT CD4 ALB
29	patent ductus arteriosus 1	29.8	IL6 CRP ALB
30	inflammatory bowel disease 1	29.8	TNF IL6 IL1B
31	aspiration pneumonitis	29.8	TNF IL6 CRP ALB
32	sickle cell anemia	29.8	TNF IL6 CRP CD4 ALB
33	folliculitis	29.8	TNF IFNG CD4
34	diverticulitis	29.8	TNF IL6 CRP ALB
35	invasive aspergillosis	29.8	TNF IL6 CRP CD4
36	autoimmune hepatitis	29.8	TNF IFNG GPT ALB
37	aortic dissection	29.8	TNF IL6 CRP ALB
38	mycoplasma pneumoniae pneumonia	29.7	TNF IL6 IFNG CRP CD4
39	osteomyelitis	29.7	TNF IL6 IL1B IFNG CRP
40	tetralogy of fallot	29.7	IL6 CYBA CRP ALB
41	bronchiolitis obliterans	29.7	TNF IL6 IFNG CRP
42	brucellosis	29.7	TNF IL6 IFNG CRP
43	secondary syphilis	29.7	TNF GPT CRP CD4
44	polyarteritis nodosa	29.7	TNF IL6 GPT CRP
45	amebiasis	29.7	TNF IL6 IL1B CD4 ALB
46	liver cirrhosis	29.7	TNF IL6 GPT ALB
47	mediastinitis	29.7	LACTB IL6 CRP CD4 ALB
48	salmonellosis	29.6	TNF IL6 IL1B IFNG CD4
49	vasculitis	29.6	TNF IL6 IL1B CRP
50	legionellosis	29.6	TNF IL6 IL1B CRP CD4

Comorbidity relations with Lung Abscess via Phenotypic Disease Network (PDN):

Bronchiectasis	Bronchitis
Deficiency Anemia	Familial Atrial Fibrillation
Heart Disease	Postinflammatory Pulmonary Fibrosis
Protein-Energy Malnutrition	Respiratory Failure

Graphical network of the top 20 diseases related to Lung Abscess:

Sources

Symptoms & Phenotypes for Lung Abscess

UMLS symptoms related to Lung Abscess:

hemoptysis

MGI Mouse Phenotypes related to Lung Abscess:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.5	ALB CD4 CYBA IFNG IL6 NCF1
2	immune system	MP:0005387	9.4	ALB CD4 CRP CYBA DOCK8 IFNG

Sources

Drugs & Therapeutics for Lung Abscess

Drugs for Lung Abscess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Ampicillin

Approved, Vet_approved

Phase 3

69-53-4

6249

Synonyms:

(2S,5R,6R)-6-[[(2R)-2-Amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylIC ACID

(2S,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

(2S,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

6-(a-Aminophenylacetamido)penicillanic acid

6-(D(-)-alpha-Aminophenylacetamido)penicillanic acid

6-(D-(2-Amino-2-phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate

6-(D-(2-Amino-2-phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid

6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 9ci

6-D(-)-alpha-Aminophenylacetamido-penicillanic acid

ABPC

Acillin

Adobacillin

Alpen

alpha-Aminobenzylpenicillin

Amblosin

Amcill

Amfipen

Amfipen V

Aminobenzyl penicillin

Aminobenzylpenicillin

Amipenix S

AMP

Ampen

AMPI

Ampi-bol

Ampichel

Ampicil

Ampicilina

AMPICILLIN

Ampicillin (anhydrous)

Ampicillin acid

Ampicillin anhydrate

Ampicillin anhydrous

Ampicillin base

Ampicillin sodium

Ampicillin trihydrate

Ampicillin, anhydrous

AMPICILLIN/AMPICILLIN TRIHYDRATE

Ampicillina

Ampicilline

Ampicillinum

Ampi-co

Ampifarm

Ampikel

AMPILAR

Ampimed

Ampipenin

Ampiscel

Ampisyn

Ampi-tab

Ampivax

Ampivet

Amplacilina

Amplin

Amplipenyl

Amplisom

Amplital

Anhydrous ampicillin

Antibiotic KS R1

Antibiotic KS-R1

AP

Austrapen

AY 6108

AY-6108

Bayer 5427

Binotal

Bonapicillin

Britacil

BRITCIN

BRL 1341

BRL-1341

Campicillin

Cimex

Copharcilin

D-(-)-6-(a-Aminophenylacetamido)penicillanate

D-(-)-6-(a-Aminophenylacetamido)penicillanic acid

D-(-)-6-(alpha-Aminophenylacetamido)penicillanate

D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid

D-(-)-6-(Α-aminophenylacetamido)penicillanate

D-(-)-6-(Α-aminophenylacetamido)penicillanic acid

D-(−)-6-(Α-AMINOPHENYLACETAMIDO)PENICILLANIC ACID

D-(-)-alpha-Aminobenzylpenicillin

D-(-)-alpha-Aminopenicillin

D-(-)-Ampicillin

D-(−)-AMPICILLIN

D-a-Aminobenzylpenicillin

D-Ampicillin

D-Cillin

Delcillin

Deripen

Divercillin

Doktacillin

Duphacillin

Geocillin

Grampenil

Guicitrina

Guicitrine

KS-R1

KS-R1, Antibiotic

Lifeampil

Magnapen

Marcillin

Morepen

Norobrittin

Novo-ampicillin

NSC 528986

NSC-528986

Nuvapen

Olin kid

Omnipen

OMNIPEN-N

Orbicilina

P-50

Pen a

Pen ampil

Penbristol

Penbritin

PENBRITIN-S

Penbrock

Penicillin, aminobenzyl

Penicline

Penimic

Pensyn

Pentrex

Pentrexl

Pentrexyl

Pentritin

Pfizerpen a

PFIZERPEN-A

Polycillin

POLYCILLIN-N

POLYCILLIN-PRB

Ponecil

Princillin

Principen

PRINCIPEN '125'

PRINCIPEN '250'

PRINCIPEN '500'

PROBAMPACIN

Qidamp

Racenacillin

Ro-ampen

Rosampline

Roscillin

Semicillin

Servicillin

SK-Ampicillin

Sodium, ampicillin

Sumipanto

Supen

Synpenin

Texcillin

Tokiocillin

Tolomol

Totacillin

TOTACILLIN-N

Totalciclina

Totapen

Trifacilina

Trihydrate, ampicillin

Ukapen

Ultrabion

Ultrabron

Vampen

Viccillin

Vidocillin

Vidopen

WY 5103

Wypicil

2

Sulbactam

Approved

Phase 3

68373-14-8

5316

3

Estradiol

Approved, Investigational, Vet_approved

Phase 3

50-28-2

5757

Synonyms:

(+)-3,17B-ESTRADIOL

(17b)-Estra-1,3,5(10)-triene-3,17-diol

(17BETA)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

(17Β)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

(1S,10R,11S,14S,15S)-15-METHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-2,4,6-TRIENE-5,14-DIOL

(8R,9S,13S,14S,17S)-13-METHYL-6,7,8,9,11,12,14,15,16,17-DECAHYDROCYCLOPENTA[A]PHENANTHRENE-3,17-DIOL

[3H]-estradiol|[3H]-estrogen|[3H]E2|[3H]estradiol

13B-METHYL-1,3,5(10)-GONATRIENE-3,17B-OL

17 beta Estradiol

17 beta Oestradiol

17 beta-Estradiol

17 beta-Oestradiol

17b Oestradiol

17b-Estra-1,3,5(10)-triene-3,17-diol

17B-ESTRADIOL

17BETA OESTRADIOL

17BETA-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

17BETA-ESTRADIOL

17BETA-OESTRADIOL

17B-OESTRADIOL

17Β oestradiol

17Β-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

17β-estradiol

17Β-OESTRADIOL

3,17B-DIHYDROXYESTRA-1,3,5(10)-TRIENE

3,17B-ESTRADIOL

3,17-EPIDIHYDROXYESTRATRIENE

ADGYN ESTRO

AERODIOL

AGOFOLLIN

ALFATRADIOL

ALORA

ALTRAD

AMNESTROGEN

AQUADIOL

AQUAGEN

BARDIOL

BEDOL

B-ESTRADIOL

BETA-ESTRADIOL

CIS-ESTRADIOL

CLIMADERM

CLIMARA

CLIMARA PRO

COMPUDOSE

CORPAGEN

Delestrogen

DELTA-ESTRADIOL

DELTA-OESTRADIOL

DEPO-ESTRADIOL

DERMESTRIL

DERMESTRIL 100

DERMESTRIL 25

DERMESTRIL 50

DERMESTRIL SEPTEM 25

DERMESTRIL SEPTEM 50

DERMESTRIL SEPTEM 75

DESTRADIOL

D-ESTRADIOL

DIHYDROFOLLICULAR HORMONE

DIHYDROFOLLICULIN

DIHYDROMENFORMON

DIHYDROTHEELIN

DIHYDRO-THEELIN

DIHYDROXYESTRIN

DIMENFORMON

DIOGYN

DIOGYNETS

DIVIGEL

D-OESTRADIOL

E2

E2|estrogen|oestrodiol|oestrogen

E-CYPIONATE

ELESTRIM

ELESTRIN

ELLESTE SOLO

ELLESTE SOLO MX 40

ELLESTE SOLO MX 80

ENCORE

EPIESTRIOL 50

ESCLIM

ESTRA-1,3,5(10)-TRIENE-3,17B-DIOL

ESTRACE

ESTRADERM

ESTRADERM MX 100

ESTRADERM MX 25

ESTRADERM MX 50

ESTRADERM MX 75

ESTRADERM TTS

ESTRADERM TTS 100

ESTRADERM TTS 25

ESTRADERM TTS 50

ESTRADIOL

Estradiol 17 alpha

Estradiol 17 beta

Estradiol 17beta

Estradiol anhydrous

ESTRADIOL HEMIHYDRATE

Estradiol hemihydrate, (17 alpha)-isomer

Estradiol monohydrate

Estradiol orion brand

Estradiol valerate

Estradiol valeriante

Estradiol, (-)-isomer

Estradiol, (+-)-isomer

Estradiol, (16 alpha,17 alpha)-isomer

Estradiol, (16 alpha,17 beta)-isomer

Estradiol, (17-alpha)-isomer

Estradiol, (8 alpha,17 beta)-(+-)-isomer

Estradiol, (8 alpha,17 beta)-isomer

Estradiol, (9 beta,17 alpha)-isomer

Estradiol, (9 beta,17 beta)-isomer

Estradiol, monosodium salt

Estradiol, sodium salt

Estradiol-17 alpha

Estradiol-17 beta

Estradiol-17b

ESTRADIOL-17BETA

ESTRADIOL-17-BETA

Estradiol-17β

ESTRADIOLUM

ESTRADOT

ESTRALDINE

ESTRASORB

ESTRING

ESTRING VAGINAL RING

ESTROCLIM

ESTROCLIM 50

ESTROGEL

ESTROGEL HBF

ESTROGEN

ESTROVITE

EVAMIST

EVOREL

EVOREL 100

EVOREL 25

EVOREL 50

EVOREL 75

FEMATRIX 40

FEMATRIX 80

FEMESTRAL

FEMOGEN

FEMPATCH

FEMSEVEN 100

FEMSEVEN 50

FEMSEVEN 75

FOLLICYCLIN

GELESTRA

GINOSEDOL

GVNODIOL

GYNERGON

GYNODIOL

GYNOESTRYL

GYNOGEN

IMVEXXY

INNOFEM

LAMDIOL

MACRODIOL

MENOREST

MENOREST 37.5

MENOREST 50

MENOREST 75

MENORING 50

MENOSTAR

MINIVELLE

NORDICOL

Novartis pharmaceuticals brand OF estradiol

NSC-20293

NSC-9895

OESCLIM

OESTERGON

OESTRA-1,3,5(10)-TRIENE-3,17B-DIOL

OESTRADIOL

OESTRODIOL

OESTROGEL

OESTROGEN

OESTROGLANDOL

Orion brand OF estradiol

OVAHORMON

OVASTEROL

OVASTEVOL

OVOCYCLIN

OVOCYLIN

PERLATANOL

PRIMOFOL

PROFOLIOL

PROFOLIOL B

PROGYNON

Progynon depot

PROGYNON DH

Progynon-depot

Progynova

PROGYNOVA TS

SANDRENA

SANDRENA 1

SYNDIOL

SYSTEN

VAGIFEM

VAGIFEM 18

VAGIFEM 8

VIVELLE

VIVELLE-DOT

WC3011

WC-3011

ZUMENON

Β-estradiol

4

Ethinylestradiol

Approved

Phase 3

57-63-6

5991

Synonyms:

(1S,10R,11S,14R,15S)-14-ETHYNYL-15-METHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-2,4,6-TRIENE-5,14-DIOL

17 ALPHA-ETHINYLESTRADIOL

17 ALPHA-ETHYNYLESTRADIOL

17 ALPHA-ETHYNYLOESTRADIOL

17α-ethynylestradiol|ethinyl estradiol

17a-Ethinyl estradiol

17a-Ethinyl-17b-estradiol

17a-Ethinylestradiol

17a-Ethynyl-17b-oestradiol

17a-Ethynylestradiol-L7b

17a-Ethynyloestradiol

17a-Ethynyloestradiol-17b

17alpha-Ethinyl estradiol

17-Ethinyl-3,17-estradiol

17-Ethinyl-3,17-oestradiol

17-Ethinylestradiol

17-Ethynylestradiol

17-Ethynylestradiol ram

17-Ethynyloestradiol

17Α-ethinyl estradiol

17Α-ETHYNYLESTRADIOL

Alora

Amenoron

Anovlar

Chee-O-gen

Chee-O-genf

Diognat-e

Diogyn e

Diogyn-e

Dyloform

Effik brand OF ethinyl estradiol

ENOVID

ENOVID-E

Ertonyl

Esclim

Esteed

Estigyn

Estinyl

Eston-e

Estoral

Estoral {[orion]}

Estorals

Estradiol, ethinyl

Estradiol, ethynyl

Estring

Estrogen

Ethidol

Ethinoral

Ethinyl estradiol

Ethinyl estradiol hemihydrate

Ethinyl estradiol, (8 alpha)-isomer

Ethinyl estradiol, (8 alpha,17 alpha)-isomer

Ethinyl estradiol, (8 alpha,9 beta,13 alpha,14 beta)-isomer

Ethinyl estradiol, (9 beta,17 alpha)-isomer

Ethinyl oestradiol effik

Ethinylestradiol

Ethinylestradiol jenapharm

ETHINYLESTRADIOLUM

Ethinylestriol

Ethinyloestradiol

Ethinyl-oestradiol effik

ETHINYL-OESTRANOL

Ethynyl estradiol

Ethynylestradiol

ETHYNYLOESTRADIOL

Eticyclin

Eticyclol

Eticylol

Etinestrol

Etinestryl

ETINILESTRADIOL

Etinoestryl

Etistradiol

Etivex

Feminone

Fempatch

Follicoral

Ginestrene

Gynodiol

Gynolett

Hemihydrate, ethinyl estradiol

Inestra

Innofem

Jenapharm brand OF ethinyl estradiol

Jenapharm, ethinylestradiol

Kolpolyn

Linoral

Lynoral

Menolyn

Menostar

Microfollin

Microfollin forte

Neo-estrone

Nogest-S

NORINYL

Novestrol

NSC-10973

Oradiol

Orestralyn

Orestrayln

Organon brand OF ethinyl estradiol

Ovex

OVULEN

OVULEN-21

OVULEN-28

Palonyl

Perovex

Primogyn

Primogyn C

Primogyn m

Progynon C

Progynon m

Schering brand OF ethinyl estradiol

Schering-plough brand OF ethinyl estradiol

Spanestrin

Thiuram e

Thiuranide

Vagifem

Ylestrol

5

Polyestradiol phosphate

Approved

Phase 3

28014-46-2

6

Norgestimate

Approved, Investigational

Phase 3

35189-28-7

6540478

7

Moxifloxacin

Approved, Investigational

Phase 3

186826-86-8, 354812-41-2, 151096-09-2

152946

8

Anti-Bacterial Agents

Phase 3

9

beta-Lactamase Inhibitors

Phase 3

10

Anti-Infective Agents

Phase 3

11

Estradiol 3-benzoate

Phase 3

12

Estradiol 17 beta-cypionate

Phase 3

13

Contraceptives, Oral, Combined

Phase 3

14

Contraceptives, Oral

Phase 3

15

Contraceptive Agents

Phase 3

16

Norgestimate, ethinyl estradiol drug combination

Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Prospective, Multi-center, Randomized, Non-blind Trial to Assess the Efficacy and Safety of Moxifloxacin Versus Sulbactam/Ampicillin in the Treatment of Pulmonary Abscess and Aspiration Pneumonia	Completed	NCT01045902	Phase 3	Avelox (Moxifloxacin, BAY12-8039);Sulbactam/Ampicillin
2	Special Use-result Surveillance Of Unasyn-s (Kit) For Intravenous Use - A Surveillance On High-dose (>6 G Daily) Administration For Pneumonia, Lung Abscess And Peritonitis -	Completed	NCT01793688		Sulbactam Sodium/Ampicillin Sodium
3	Biomarkers for Diagnosis of Lung Nodules	Active, not recruiting	NCT01085864

Search NIH Clinical Center for Lung Abscess

Cochrane evidence based reviews: lung abscess

Sources

Genetic Tests for Lung Abscess

Sources

Anatomical Context for Lung Abscess

Organs/tissues related to Lung Abscess:

MalaCards : Lung, Liver, Brain, Heart, Trachea, Spinal Cord, Bone Marrow

Sources

Publications for Lung Abscess

Articles related to Lung Abscess:

(show top 50) (show all 2562)

#	Title	Authors	PMID	Year
1	Aspiration pneumonia and primary lung abscess: diagnosis and therapy of an aerobic or an anaerobic infection? ⁵³ ⁶²	Allewelt M	20477271	2007
2	Changing bacteriology of adult community-acquired lung abscess in Taiwan: Klebsiella pneumoniae versus anaerobes. ⁵³ ⁶²	Wang JL...Chang SC	15824979	2005
3	[A comparative study of tazobactam/piperacillin and piperacillin in bacterial pneumonia]. ⁵³ ⁶²	Oizumi K...Takebe K	7783313	1995
4	Pulmonary arterial pseudoaneurysm as an unusual complication of pulmonary actinomycosis: Two case reports. ⁶²	Urushibara A...Nakajima T	36340225	2023
5	Correlation of MRSA polymerase chain reaction (PCR) nasal swab in ventilator-associated pneumonia, lung abscess, and empyema. ⁶²	Lewis AD...Orwig KW	36370541	2023
6	A CT-based radiomics nomogram for the differentiation of pulmonary cystic echinococcosis from pulmonary abscess. ⁶²	Li Y...Xing Y	36181541	2022
7	Nodule-type pneumonitis mimicking lung abscess or tumor recurrence on chest computed tomography identified as osimertinib-induced pneumonitis: A case report. ⁶²	Otsuki A...Nakashima K	36208137	2022
8	[Clinical presentation and short-term treatment of pulmonary actinomycosis]. ⁶²	Abdulkarim A...Kokkinakis I	36382979	2022
9	Uncommon Cause of Hemoptysis in a 15-Year-Old Boy. ⁶²	de Manuel Gomez C...de la Torre Ramos CA	36210107	2022
10	Case 306: Ectopic Thyroid Goiter in the Porta Hepatis. ⁶²	Mamone G...Miraglia R	36154285	2022
11	Propionibacterium acnes: an uncommon cause of lung abscess in chronic obstructive pulmonary disease complicated with bullous emphysema. ⁶²	Adlakha A...Muppala N	35822717	2022
12	Limited Granulomatosis With Polyangiitis Presenting as Recurrent Lung Abscess Without Pneumonia. ⁶²	Chippa V...Candula N	36337814	2022
13	Endobronchial Actinomycosis: A Case Report. ⁶²	Afsin E...Bacaksu E	36308251	2022
14	Lung abscess and empyema in a heart transplant recipient from Thailand. ⁶²	Bruminhent J...Clemente WT	36305598	2022
15	Novel Bronchoscopic Drainage Technique in Multiple Drug Resistant Acinetobacter Lung Abscess: A Case Report. ⁶²	Shalata W...Raviv Y	36309866	2022
16	Lung abscess initially misdiagnosed as a liver abscess. ⁶²	Matsuo Y...Hiraoka E	35545141	2022
17	Comparative genomics of Trueperella pyogenes available in the genome database reveals multidrug resistance genomic islands. ⁶²	Karthik K...Sridhar R	36210029	2022
18	Tracheo-esophageal fistula and pleural empyema in the course of SARS-CoV-2 infection-A case report. ⁶²	Kubik H...Rydel M	36213004	2022
19	Infectious Pulmonary Artery Pseudoaneurysm That Resolved with Conservative Treatment. ⁶²	Nakayama T...Sugiyama H	35283388	2022
20	Ultrasound assessment of pulmonary abscess. ⁶²	Mongodi S...Mojoli F	36272907	2022
21	Predictors of Readmission Following Treatment for Traumatic Hemothorax. ⁶²	Kirchberg TN...Godat LN	35569214	2022
22	A Life-Threatening Infection after Endobronchial Ultrasound Transbronchial Lung Biopsy with Guide Sheath: A Case Report. ⁶²	Kim I...Eom JS	36143952	2022
23	Use of extracorporeal membrane oxygenation in non-elective major thoracic surgery for infectious lung abscess. ⁶²	Schweigert M...Stein HJ	35213707	2022
24	Point-of-care ultrasound in the pediatric emergency department to diagnose lung abscess. ⁶²	Giachetti E...Urbino AF	36089539	2022
25	Isolation of Raoultella ornithinolytica in a HIV positive patient with a lung abscess. ⁶²	Hinchcliffe N...Venkatesan P	36004361	2022
26	Management of Pulmonary Hydatidosis and Lung Abscess in Low-Resource Settings. ⁶²	Sotomayor A...Mody GN	35961743	2022
27	Perforated retrocecal appendicitis presenting with lung abscess-A case report. ⁶²	Faizi FR...Farzam F	35990571	2022
28	The Mass-Querade: Lung Abscess Mimicking Primary Lung Cancer. ⁶²	Akinboboye O...Walls S	36106291	2022
29	Case Report: Disseminated Burkholderia pseudomallei with Acute Suppurative Thyroiditis and Abscess Formation. ⁶²	Harris J...Hanson J	35914690	2022
30	Esophagectomy for Permanent Mesh Migration After Transthoracic Hiatal Hernia Repair. ⁶²	Yin V...Wightman SC	34914935	2022
31	Ultrasonographic diagnosis of clinical and subclinical bovine respiratory disease in Holstein calves. ⁶²	Mahmoud AE...El-Maghraby MM	36313833	2022
32	[Chinese expert consensus on the management of lower respiratory tract infections of Pseudomonas aeruginosa in adults(2022)]. ⁶²	Pulmonary Infection Assembly of Chinese Thoracic Society	35927044	2022
33	Delayed diagnosis of foreign body aspiration in children. ⁶²	Rance A...Labouret G	35705387	2022
34	The extract of Celtis choseniana Nakai alleviates testosterone-induced benign prostatic hyperplasia through inhibiting 5α reductase type 2 and the Akt/NF-κB/AR pathway. ⁶²	Hong GL...Jung JY	35907650	2022
35	A Case of Intractable Lung Abscess Following Dropped Gallstone-Induced Subphrenic Abscess: A Rare Postoperative Complication Caused by Dropped Gallstone During Laparoscopic Cholecystectomy. ⁶²	Nagata K...Osaki T	36060363	2022
36	Granulomatosis with polyangiitis presenting as a pulmonary abscess. ⁶²	Itoh R...Awaya Y	35348795	2022
37	A new strategy in lung/lobe isolation in patients with a lung abscess or a previous lung resection using double lumen tubes combined with bronchial blockers. ⁶²	Gil MG...De Andres J	35799564	2022
38	Lung Abscess in Adult with Foreign Body (Tooth). ⁶²	da Trindade JGA...Fontes CAP	35314133	2022
39	Case report on peri-operative surgical and anaesthetic management of ruptured humongous lung abscess. ⁶²	Siddiqui KM...Yousuf MS	35868131	2022
40	Lung abscess caused by Rhodococcus equi in a patient with advanced retroviral disease. ⁶²	Chang CY...Ong ELC	35865762	2022
41	Lung Abscess Case Series and Review of the Literature. ⁶²	Yousef L...Al-Shamrani A	35884031	2022
42	Adult T Cell Leukemia/Lymphoma Becoming Apparent during Treatment of Pulmonary Abscess and Empyema Caused by Nocardia asiatica: A Case Report and Review of the Literature. ⁶²	Hayashi Y...Fukui M	34980794	2022
43	Lung abscess: 14 years of experience in a tertiary paediatric hospital. ⁶²	Fernando DT...Gera P	35678219	2022
44	Hydrocarbon pneumonitis with abscess formation following diesel siphoning. ⁶²	Rajpoot A...Rathore SS	35764339	2022
45	Ultrasonography in the diagnosis of lung abscess. ⁶²	Cheong I	35285031	2022
46	Actinomyces odontolyticus lung abscess and pleural empyema. ⁶²	Ruan H...Li SS	35943021	2022
47	Pulmonary actinomycosis and polymicrobial empyema in a patient with ABPA and bronchocoele. ⁶²	Tu J...Mansfield D	35509978	2022
48	Middle Pulmonary Lobe Abscess: A Delayed Complication of Laparoscopic Cholecystectomy. ⁶²	Leopa N...Popescu RC	35792546	2022
49	Case 306. ⁶²	Mamone G...Miraglia R	35604842	2022
50	A novel angiographic classification of pseudoaneurysms of the pulmonary chronic inflammatory cavity based on selective angiograms and therapeutic implications. ⁶²	Chen S...Zhao Z	35813718	2022

Sources

Genes for Lung Abscess

Genes related to Lung Abscess (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	LACTB	Lactamase Beta	Protein Coding	13.46	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7783313 15824979 20477271
2	CRP	C-Reactive Protein	Protein Coding	7.04	DISEASES inferred ¹⁴
3	IGES	Immunoglobulin E Concentration, Serum	Genetic Locus	5.62	Novoseek inferred ⁵³	16940164
4	ALB	Albumin	Protein Coding	5.54	DISEASES inferred ¹⁴
5	IL6	Interleukin 6	Protein Coding	5.2	DISEASES inferred ¹⁴
6	CD4	CD4 Molecule	Protein Coding	5.2	DISEASES inferred ¹⁴
7	TNF	Tumor Necrosis Factor	Protein Coding	5.15	DISEASES inferred ¹⁴
8	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	5.02	DISEASES inferred ¹⁴
9	DOCK8	Dedicator Of Cytokinesis 8	Protein Coding	5	DISEASES inferred ¹⁴
10	IFNG	Interferon Gamma	Protein Coding	4.96	DISEASES inferred ¹⁴
11	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	4.94	DISEASES inferred ¹⁴
12	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	4.93	DISEASES inferred ¹⁴
13	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	4.89	DISEASES inferred ¹⁴
14	HSPE1	Heat Shock Protein Family E (Hsp10) Member 1	Protein Coding	4.82	DISEASES inferred ¹⁴
15	IL1B	Interleukin 1 Beta	Protein Coding	4.81	DISEASES inferred ¹⁴
16	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	4.8	DISEASES inferred ¹⁴

Sources

Variations for Lung Abscess

Sources

Expression for Lung Abscess

Search GEO for disease gene expression data for Lung Abscess.

Sources

Pathways for Lung Abscess

Pathways related to Lung Abscess according to GeneCards Suite gene sharing:

(show top 50) (show all 55)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.91	CD4 CRP CYBA IFNG IL1B IL6
2	Signal Transduction ⁶⁶	13.73	TNF NCF4 NCF2 NCF1 IL6 HSPE1
3	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.25	TNF NCF4 NCF2 NCF1 IL6 IL1B
4	Nuclear events mediated by NFE2L2 ⁶⁶ Show member pathways Cellular response to chemical stress ⁶⁶ Cytoprotection by HMOX1 ⁶⁶ KEAP1-NFE2L2 pathway ⁶⁶ NFE2L2 regulates pentose phosphate pathway genes ⁶⁶ NFE2L2 regulating anti-oxidant/detoxification enzymes ⁶⁶ NFE2L2 regulating TCA cycle genes ⁶⁶ Regulation of BACH1 activity ⁶⁶ Regulation of HMOX1 expression and activity ⁶⁶ Regulation of NFE2L2 gene expression ⁶⁶	12.78	ALB CYBA NCF1 NCF2 NCF4
5	RAC1 GTPase cycle ⁶⁶ Show member pathways CDC42 GTPase cycle ⁶⁶	12.55	NCF4 NCF2 NCF1 DOCK8 CYBA
6	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.55	TNF IL6 IL1B IFNG CD4
7	NF-kappaB Signaling ³	12.52	TNF NCF4 NCF1 IL1B IFNG
8	Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling ⁶⁵ Show member pathways Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling ⁶⁵ Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling ⁶⁵ Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling ⁶⁵	12.44	CYBA NCF1 NCF2 NCF4
9	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.39	TNF IL6 IL1B IFNG
10	RAC2 GTPase cycle ⁶⁶ Show member pathways RAC3 GTPase cycle ⁶⁶ RHOG GTPase cycle ⁶⁶	12.37	NCF4 NCF2 NCF1 HSPE1 CYBA
11	Antigen processing-Cross presentation ⁶⁶ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁶ Endosomal/Vacuolar pathway ⁶⁶ ER-Phagosome pathway ⁶⁶	12.31	NCF4 NCF2 NCF1 CYBA
12	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.3	TNF IL6 IL1B IFNG
13	Signaling by VEGF ⁶⁶ Show member pathways VEGFA-VEGFR2 Pathway ⁶⁶	12.29	NCF4 NCF2 NCF1 CYBA
14	Insulin receptor recycling ⁶⁶ Show member pathways ATP biosynthesis ⁶¹ Events associated with phagocytolytic activity of PMN cells ⁶⁶ Iron uptake and transport ⁶⁶ melatonin degradation III ⁶¹ ROS and RNS production in phagocytes ⁶⁶ Transferrin endocytosis and recycling ⁶⁶	12.18	NCF4 NCF2 NCF1 CYBA
15	Neuroinflammation and glutamatergic signaling ⁷⁴	12.08	TNF IL6 IL1B IFNG
16	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.95	TNF IL6 IFNG CD4
17	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.94	IL1B IFNG CD4
18	Spinal cord injury ⁷⁴	11.94	TNF IL6 IL1B IFNG
19	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.92	TNF IL6 IL1B
20	Senescence and autophagy in cancer ⁷⁴	11.91	IL6 IL1B IFNG
21	Allograft rejection ⁷⁴	11.85	TNF IL1B IFNG
22	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions ²² Show member pathways Inhibitory action of Lipoxins on Superoxide production in neutrophils ²²	11.82	NCF4 NCF2 NCF1 CYBA
23	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.81	IL6 IL1B IFNG CD4
24	Activation of NF-KappaB by PKR ⁶⁴ Show member pathways Canonical NF-kB pathway ⁷⁴ Cellular Transformation by HTLV1 ⁶⁴ Inhibition of PKR ⁶⁶ STING pathway in Kawasaki-like disease and COVID-19 ⁷⁴	11.78	TNF IL1B IFNG
25	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.76	IL6 CRP CD4
26	Burn wound healing ⁷⁴	11.74	TNF IL6 IL1B
27	Acute viral myocarditis ⁷⁴	11.74	IL6 IFNG CD4
28	Innate Lymphoid Cells Differentiation ⁶⁵	11.73	CD4 IFNG IL1B TNF
29	Microglia pathogen phagocytosis pathway ⁷⁴ Show member pathways GPVI-mediated activation cascade ⁶⁶	11.69	NCF4 NCF2 NCF1 CYBA
30	Lung fibrosis ⁷⁴	11.66	TNF IL6 IL1B
31	IL 10 signaling pathway ⁶⁷	11.65	IL1B IL6 TNF
32	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.65	TNF IL6 IFNG CRP
33	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.65	TNF IL6 IL1B IFNG CD4
34	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.62	TNF IL6 IFNG
35	Th17 cell differentiation pathway ⁷⁴	11.62	IL6 IL1B IFNG CD4
36	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.56	TNF IL6 IL1B IFNG
37	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.55	TNF IL6 IFNG
38	IL-18 signaling pathway ⁷⁴	11.53	TNF NCF2 NCF1
39	MSP-RON Signaling ⁶⁴	11.51	TNF IL1B IFNG
40	Interleukin-10 signaling ⁶⁶	11.49	TNF IL6 IL1B
41	Detoxification of Reactive Oxygen Species ⁶⁶ Show member pathways Oxidative Stress Regulatory Pathway (Erythrocyte) ⁶⁰ reactive oxygen species degradation ⁶¹	11.44	NCF4 NCF2 NCF1 CYBA
42	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.36	TNF IL6 IL1B IFNG
43	IL-10 Pathway ⁶⁴	11.35	IL1B IL6 TNF
44	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.26	TNF IL6 IL1B
45	Genetic causes of porto-sinusoidal vascular disease ⁷⁴	11.24	CYBA NCF1 NCF2 NCF4
46	Prostaglandin signaling ⁷⁴	11.22	TNF IL6 IL1B
47	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.22	TNF IL6 IL1B IFNG CD4
48	Immune infiltration in pancreatic cancer ⁷⁴	11.2	IFNG IL6 TNF
49	Development and heterogeneity of the ILC family ⁷⁴	11.13	TNF IL6 IL1B IFNG
50	Overview of nanoparticle effects ⁷⁴	10.99	TNF IL6 CRP

Sources

GO Terms for Lung Abscess

Cellular components related to Lung Abscess according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phagolysosome	GO:0032010	9.43	NCF4 NCF2 NCF1
2	NADPH oxidase complex	GO:0043020	9.23	NCF4 NCF2 NCF1 CYBA

Biological processes related to Lung Abscess according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to Gram-positive bacterium	GO:0050830	10.18	CRP IL1B IL6 TNF
2	positive regulation of smooth muscle cell proliferation	GO:0048661	10.09	TNF IL6 CYBA
3	cellular response to organic cyclic compound	GO:0071407	10.09	TNF IL1B CYBA
4	response to activity	GO:0014823	10.08	TNF IL6 CYBA
5	positive regulation of phagocytosis	GO:0050766	10.08	TNF IL1B IFNG CYBA
6	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.07	TNF IL1B IFNG
7	negative regulation of neurogenesis	GO:0050768	10.03	TNF IL6 IL1B
8	regulation of insulin secretion	GO:0050796	10.03	IFNG IL1B IL6 TNF
9	superoxide metabolic process	GO:0006801	10.01	NCF2 NCF1 CYBA
10	positive regulation of glial cell proliferation	GO:0060252	10	TNF IL6 IL1B
11	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.99	TNF IL1B IFNG
12	astrocyte activation	GO:0048143	9.97	IFNG IL1B TNF
13	positive regulation of interleukin-6 production	GO:0032755	9.96	TNF IL6 IL1B IFNG CYBA
14	positive regulation of neuroinflammatory response	GO:0150078	9.93	TNF IL6 IL1B
15	positive regulation of chemokine production	GO:0032722	9.91	TNF IL6 IL1B IFNG
16	positive regulation of fever generation	GO:0031622	9.9	TNF IL1B
17	sequestering of triglyceride	GO:0030730	9.88	TNF IL1B
18	negative regulation of lipid storage	GO:0010888	9.88	TNF IL6 CRP
19	positive regulation of nitrogen compound metabolic process	GO:0051173	9.87	TNF IFNG
20	positive regulation of vitamin D biosynthetic process	GO:0060557	9.85	TNF IFNG
21	vascular endothelial growth factor production	GO:0010573	9.8	IL1B IL6 TNF
22	superoxide anion generation	GO:0042554	9.76	NCF4 NCF2 NCF1 CYBA
23	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.43	TNF IL1B IFNG
24	respiratory burst	GO:0045730	9.23	NCF4 NCF2 NCF1 CYBA

Molecular functions related to Lung Abscess according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	superoxide-generating NAD(P)H oxidase activity	GO:0016175	9.43	NCF2 NCF1 CYBA
2	superoxide-generating NADPH oxidase activator activity	GO:0016176	9.1	NCF4 NCF2 NCF1

Sources

Sources for Lung Abscess

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LNG095 MIFTS: 50	Lung Abscess Categories: Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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