MCID: LNG095
MIFTS: 50

Lung Abscess

Categories: Respiratory diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Lung Abscess

MalaCards integrated aliases for Lung Abscess:

Name: Lung Abscess 11 53 43 14 16 71 75
Multiple Abscess of Lung 33
Apical Lung Abscess 33
Abscess of Lung Nos 33
Pulmonary Abscess 33
Abscess of Lung 33

Classifications:



External Ids:

Disease Ontology 11 DOID:0060317
ICD9CM 34 513.0
MeSH 43 D008169
NCIt 49 C99090
SNOMED-CT 68 155618005
ICD10 31 J85.1 J85.2
UMLS 71 C0024110

Summaries for Lung Abscess

Disease Ontology: 11 A lung disease characterized by microbial infection which causes a type of liquefactive necrosis of the pulmonary tissue and formation of cavities containing necrotic debris or fluid.

MalaCards based summary: Lung Abscess, also known as multiple abscess of lung, is related to pleural empyema and aspergillosis, and has symptoms including hemoptysis An important gene associated with Lung Abscess is LACTB (Lactamase Beta), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Ampicillin and Sulbactam have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and brain, and related phenotypes are digestive/alimentary and immune system

Wikipedia: 75 Lung abscess is a type of liquefactive necrosis of the lung tissue and formation of cavities (more than... more...

Related Diseases for Lung Abscess

Diseases related to Lung Abscess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1048)
# Related Disease Score Top Affiliating Genes
1 pleural empyema 31.7 IL6 GPT CRP CD4 ALB
2 aspergillosis 31.3 TNF IL6 IL1B IFNG
3 aspiration pneumonia 30.6 TNF LACTB IL6 IL1B GPT CRP
4 intracranial abscess 30.4 LACTB CRP CD4
5 klebsiella pneumonia 30.3 LACTB GPT CRP ALB
6 hyper ige recurrent infection syndrome 1 30.3 IL6 DOCK8 CD4
7 nocardiosis 30.3 TNF CRP CD4
8 actinomycosis 30.3 TNF CRP CD4 ALB
9 echinococcosis 30.3 TNF IL6 IFNG
10 allergic bronchopulmonary aspergillosis 30.2 IGES IFNG CD4
11 infective endocarditis 30.2 IL6 CRP ALB
12 melioidosis 30.2 TNF IL6 IFNG
13 acute kidney failure 30.2 IL6 GPT ALB
14 nutritional deficiency disease 30.1 IL6 CRP ALB
15 croup 30.1 IL6 CRP CD4
16 haemophilus influenzae 30.1 TNF LACTB IL1B
17 legionnaire disease 30.1 TNF IL6 IL1B CRP CD4
18 enterocolitis 30.0 TNF IL6 CRP
19 disseminated intravascular coagulation 30.0 TNF IL6 GPT CRP
20 spontaneous tension pneumothorax 30.0 GPT CRP
21 inappropriate adh syndrome 30.0 IL6 CRP ALB
22 discitis 30.0 CRP ALB
23 anemia, autoimmune hemolytic 29.9 IL6 CRP CD4
24 adult syndrome 29.9 TNF IL6 CRP
25 endocarditis 29.9 TNF LACTB IL6 IFNG CRP ALB
26 diabetes mellitus, ketosis-prone 29.9 GPT CRP ALB
27 bronchiectasis 29.9 TNF IL6 IL1B IFNG CRP ALB
28 ascaris lumbricoides infection 29.8 GPT CD4 ALB
29 patent ductus arteriosus 1 29.8 IL6 CRP ALB
30 inflammatory bowel disease 1 29.8 TNF IL6 IL1B
31 aspiration pneumonitis 29.8 TNF IL6 CRP ALB
32 sickle cell anemia 29.8 TNF IL6 CRP CD4 ALB
33 folliculitis 29.8 TNF IFNG CD4
34 diverticulitis 29.8 TNF IL6 CRP ALB
35 invasive aspergillosis 29.8 TNF IL6 CRP CD4
36 autoimmune hepatitis 29.8 TNF IFNG GPT ALB
37 aortic dissection 29.8 TNF IL6 CRP ALB
38 mycoplasma pneumoniae pneumonia 29.7 TNF IL6 IFNG CRP CD4
39 osteomyelitis 29.7 TNF IL6 IL1B IFNG CRP
40 tetralogy of fallot 29.7 IL6 CYBA CRP ALB
41 bronchiolitis obliterans 29.7 TNF IL6 IFNG CRP
42 brucellosis 29.7 TNF IL6 IFNG CRP
43 secondary syphilis 29.7 TNF GPT CRP CD4
44 polyarteritis nodosa 29.7 TNF IL6 GPT CRP
45 amebiasis 29.7 TNF IL6 IL1B CD4 ALB
46 liver cirrhosis 29.7 TNF IL6 GPT ALB
47 mediastinitis 29.7 LACTB IL6 CRP CD4 ALB
48 salmonellosis 29.6 TNF IL6 IL1B IFNG CD4
49 vasculitis 29.6 TNF IL6 IL1B CRP
50 legionellosis 29.6 TNF IL6 IL1B CRP CD4

Comorbidity relations with Lung Abscess via Phenotypic Disease Network (PDN):


Bronchiectasis Bronchitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Protein-Energy Malnutrition Respiratory Failure

Graphical network of the top 20 diseases related to Lung Abscess:



Diseases related to Lung Abscess

Symptoms & Phenotypes for Lung Abscess

UMLS symptoms related to Lung Abscess:


hemoptysis

MGI Mouse Phenotypes related to Lung Abscess:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 ALB CD4 CYBA IFNG IL6 NCF1
2 immune system MP:0005387 9.4 ALB CD4 CRP CYBA DOCK8 IFNG

Drugs & Therapeutics for Lung Abscess

Drugs for Lung Abscess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ampicillin Approved, Vet_approved Phase 3 69-53-4 6249
2
Sulbactam Approved Phase 3 68373-14-8 5316
3
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
4
Ethinylestradiol Approved Phase 3 57-63-6 5991
5
Polyestradiol phosphate Approved Phase 3 28014-46-2
6
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
7
Moxifloxacin Approved, Investigational Phase 3 186826-86-8, 354812-41-2, 151096-09-2 152946
8 Anti-Bacterial Agents Phase 3
9 beta-Lactamase Inhibitors Phase 3
10 Anti-Infective Agents Phase 3
11 Estradiol 3-benzoate Phase 3
12 Estradiol 17 beta-cypionate Phase 3
13 Contraceptives, Oral, Combined Phase 3
14 Contraceptives, Oral Phase 3
15 Contraceptive Agents Phase 3
16 Norgestimate, ethinyl estradiol drug combination Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Multi-center, Randomized, Non-blind Trial to Assess the Efficacy and Safety of Moxifloxacin Versus Sulbactam/Ampicillin in the Treatment of Pulmonary Abscess and Aspiration Pneumonia Completed NCT01045902 Phase 3 Avelox (Moxifloxacin, BAY12-8039);Sulbactam/Ampicillin
2 Special Use-result Surveillance Of Unasyn-s (Kit) For Intravenous Use - A Surveillance On High-dose (>6 G Daily) Administration For Pneumonia, Lung Abscess And Peritonitis - Completed NCT01793688 Sulbactam Sodium/Ampicillin Sodium
3 Biomarkers for Diagnosis of Lung Nodules Active, not recruiting NCT01085864

Search NIH Clinical Center for Lung Abscess

Cochrane evidence based reviews: lung abscess

Genetic Tests for Lung Abscess

Anatomical Context for Lung Abscess

Organs/tissues related to Lung Abscess:

MalaCards : Lung, Liver, Brain, Heart, Trachea, Spinal Cord, Bone Marrow

Publications for Lung Abscess

Articles related to Lung Abscess:

(show top 50) (show all 2562)
# Title Authors PMID Year
1
Aspiration pneumonia and primary lung abscess: diagnosis and therapy of an aerobic or an anaerobic infection? 53 62
20477271 2007
2
Changing bacteriology of adult community-acquired lung abscess in Taiwan: Klebsiella pneumoniae versus anaerobes. 53 62
15824979 2005
3
[A comparative study of tazobactam/piperacillin and piperacillin in bacterial pneumonia]. 53 62
7783313 1995
4
Pulmonary arterial pseudoaneurysm as an unusual complication of pulmonary actinomycosis: Two case reports. 62
36340225 2023
5
Correlation of MRSA polymerase chain reaction (PCR) nasal swab in ventilator-associated pneumonia, lung abscess, and empyema. 62
36370541 2023
6
A CT-based radiomics nomogram for the differentiation of pulmonary cystic echinococcosis from pulmonary abscess. 62
36181541 2022
7
Nodule-type pneumonitis mimicking lung abscess or tumor recurrence on chest computed tomography identified as osimertinib-induced pneumonitis: A case report. 62
36208137 2022
8
[Clinical presentation and short-term treatment of pulmonary actinomycosis]. 62
36382979 2022
9
Uncommon Cause of Hemoptysis in a 15-Year-Old Boy. 62
36210107 2022
10
Case 306: Ectopic Thyroid Goiter in the Porta Hepatis. 62
36154285 2022
11
Propionibacterium acnes: an uncommon cause of lung abscess in chronic obstructive pulmonary disease complicated with bullous emphysema. 62
35822717 2022
12
Limited Granulomatosis With Polyangiitis Presenting as Recurrent Lung Abscess Without Pneumonia. 62
36337814 2022
13
Endobronchial Actinomycosis: A Case Report. 62
36308251 2022
14
Lung abscess and empyema in a heart transplant recipient from Thailand. 62
36305598 2022
15
Novel Bronchoscopic Drainage Technique in Multiple Drug Resistant Acinetobacter Lung Abscess: A Case Report. 62
36309866 2022
16
Lung abscess initially misdiagnosed as a liver abscess. 62
35545141 2022
17
Comparative genomics of Trueperella pyogenes available in the genome database reveals multidrug resistance genomic islands. 62
36210029 2022
18
Tracheo-esophageal fistula and pleural empyema in the course of SARS-CoV-2 infection-A case report. 62
36213004 2022
19
Infectious Pulmonary Artery Pseudoaneurysm That Resolved with Conservative Treatment. 62
35283388 2022
20
Ultrasound assessment of pulmonary abscess. 62
36272907 2022
21
Predictors of Readmission Following Treatment for Traumatic Hemothorax. 62
35569214 2022
22
A Life-Threatening Infection after Endobronchial Ultrasound Transbronchial Lung Biopsy with Guide Sheath: A Case Report. 62
36143952 2022
23
Use of extracorporeal membrane oxygenation in non-elective major thoracic surgery for infectious lung abscess. 62
35213707 2022
24
Point-of-care ultrasound in the pediatric emergency department to diagnose lung abscess. 62
36089539 2022
25
Isolation of Raoultella ornithinolytica in a HIV positive patient with a lung abscess. 62
36004361 2022
26
Management of Pulmonary Hydatidosis and Lung Abscess in Low-Resource Settings. 62
35961743 2022
27
Perforated retrocecal appendicitis presenting with lung abscess-A case report. 62
35990571 2022
28
The Mass-Querade: Lung Abscess Mimicking Primary Lung Cancer. 62
36106291 2022
29
Case Report: Disseminated Burkholderia pseudomallei with Acute Suppurative Thyroiditis and Abscess Formation. 62
35914690 2022
30
Esophagectomy for Permanent Mesh Migration After Transthoracic Hiatal Hernia Repair. 62
34914935 2022
31
Ultrasonographic diagnosis of clinical and subclinical bovine respiratory disease in Holstein calves. 62
36313833 2022
32
[Chinese expert consensus on the management of lower respiratory tract infections of Pseudomonas aeruginosa in adults(2022)]. 62
35927044 2022
33
Delayed diagnosis of foreign body aspiration in children. 62
35705387 2022
34
The extract of Celtis choseniana Nakai alleviates testosterone-induced benign prostatic hyperplasia through inhibiting 5α reductase type 2 and the Akt/NF-κB/AR pathway. 62
35907650 2022
35
A Case of Intractable Lung Abscess Following Dropped Gallstone-Induced Subphrenic Abscess: A Rare Postoperative Complication Caused by Dropped Gallstone During Laparoscopic Cholecystectomy. 62
36060363 2022
36
Granulomatosis with polyangiitis presenting as a pulmonary abscess. 62
35348795 2022
37
A new strategy in lung/lobe isolation in patients with a lung abscess or a previous lung resection using double lumen tubes combined with bronchial blockers. 62
35799564 2022
38
Lung Abscess in Adult with Foreign Body (Tooth). 62
35314133 2022
39
Case report on peri-operative surgical and anaesthetic management of ruptured humongous lung abscess. 62
35868131 2022
40
Lung abscess caused by Rhodococcus equi in a patient with advanced retroviral disease. 62
35865762 2022
41
Lung Abscess Case Series and Review of the Literature. 62
35884031 2022
42
Adult T Cell Leukemia/Lymphoma Becoming Apparent during Treatment of Pulmonary Abscess and Empyema Caused by Nocardia asiatica: A Case Report and Review of the Literature. 62
34980794 2022
43
Lung abscess: 14 years of experience in a tertiary paediatric hospital. 62
35678219 2022
44
Hydrocarbon pneumonitis with abscess formation following diesel siphoning. 62
35764339 2022
45
Ultrasonography in the diagnosis of lung abscess. 62
35285031 2022
46
Actinomyces odontolyticus lung abscess and pleural empyema. 62
35943021 2022
47
Pulmonary actinomycosis and polymicrobial empyema in a patient with ABPA and bronchocoele. 62
35509978 2022
48
Middle Pulmonary Lobe Abscess: A Delayed Complication of Laparoscopic Cholecystectomy. 62
35792546 2022
49
Case 306. 62
35604842 2022
50
A novel angiographic classification of pseudoaneurysms of the pulmonary chronic inflammatory cavity based on selective angiograms and therapeutic implications. 62
35813718 2022

Variations for Lung Abscess

Expression for Lung Abscess

Search GEO for disease gene expression data for Lung Abscess.

Pathways for Lung Abscess

Pathways related to Lung Abscess according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CD4 CRP CYBA IFNG IL1B IL6
2 13.73 TNF NCF4 NCF2 NCF1 IL6 HSPE1
3
Show member pathways
13.25 TNF NCF4 NCF2 NCF1 IL6 IL1B
4
Show member pathways
12.78 ALB CYBA NCF1 NCF2 NCF4
5
Show member pathways
12.55 NCF4 NCF2 NCF1 DOCK8 CYBA
6
Show member pathways
12.55 TNF IL6 IL1B IFNG CD4
7 12.52 TNF NCF4 NCF1 IL1B IFNG
8
Show member pathways
12.44 CYBA NCF1 NCF2 NCF4
9
Show member pathways
12.39 TNF IL6 IL1B IFNG
10
Show member pathways
12.37 NCF4 NCF2 NCF1 HSPE1 CYBA
11
Show member pathways
12.31 NCF4 NCF2 NCF1 CYBA
12
Show member pathways
12.3 TNF IL6 IL1B IFNG
13
Show member pathways
12.29 NCF4 NCF2 NCF1 CYBA
14
Show member pathways
12.18 NCF4 NCF2 NCF1 CYBA
15 12.08 TNF IL6 IL1B IFNG
16 11.95 TNF IL6 IFNG CD4
17
Show member pathways
11.94 IL1B IFNG CD4
18 11.94 TNF IL6 IL1B IFNG
19 11.92 TNF IL6 IL1B
20 11.91 IL6 IL1B IFNG
21 11.85 TNF IL1B IFNG
22
Show member pathways
11.82 NCF4 NCF2 NCF1 CYBA
23
Show member pathways
11.81 IL6 IL1B IFNG CD4
24
Show member pathways
11.78 TNF IL1B IFNG
25
Show member pathways
11.76 IL6 CRP CD4
26 11.74 TNF IL6 IL1B
27 11.74 IL6 IFNG CD4
28 11.73 CD4 IFNG IL1B TNF
29
Show member pathways
11.69 NCF4 NCF2 NCF1 CYBA
30 11.66 TNF IL6 IL1B
31 11.65 IL1B IL6 TNF
32 11.65 TNF IL6 IFNG CRP
33
Show member pathways
11.65 TNF IL6 IL1B IFNG CD4
34
Show member pathways
11.62 TNF IL6 IFNG
35 11.62 IL6 IL1B IFNG CD4
36
Show member pathways
11.56 TNF IL6 IL1B IFNG
37 11.55 TNF IL6 IFNG
38 11.53 TNF NCF2 NCF1
39 11.51 TNF IL1B IFNG
40 11.49 TNF IL6 IL1B
41
Show member pathways
11.44 NCF4 NCF2 NCF1 CYBA
42 11.36 TNF IL6 IL1B IFNG
43 11.35 IL1B IL6 TNF
44 11.26 TNF IL6 IL1B
45 11.24 CYBA NCF1 NCF2 NCF4
46 11.22 TNF IL6 IL1B
47 11.22 TNF IL6 IL1B IFNG CD4
48 11.2 IFNG IL6 TNF
49 11.13 TNF IL6 IL1B IFNG
50 10.99 TNF IL6 CRP

GO Terms for Lung Abscess

Cellular components related to Lung Abscess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagolysosome GO:0032010 9.43 NCF4 NCF2 NCF1
2 NADPH oxidase complex GO:0043020 9.23 NCF4 NCF2 NCF1 CYBA

Biological processes related to Lung Abscess according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 10.18 CRP IL1B IL6 TNF
2 positive regulation of smooth muscle cell proliferation GO:0048661 10.09 TNF IL6 CYBA
3 cellular response to organic cyclic compound GO:0071407 10.09 TNF IL1B CYBA
4 response to activity GO:0014823 10.08 TNF IL6 CYBA
5 positive regulation of phagocytosis GO:0050766 10.08 TNF IL1B IFNG CYBA
6 positive regulation of nitric oxide biosynthetic process GO:0045429 10.07 TNF IL1B IFNG
7 negative regulation of neurogenesis GO:0050768 10.03 TNF IL6 IL1B
8 regulation of insulin secretion GO:0050796 10.03 IFNG IL1B IL6 TNF
9 superoxide metabolic process GO:0006801 10.01 NCF2 NCF1 CYBA
10 positive regulation of glial cell proliferation GO:0060252 10 TNF IL6 IL1B
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.99 TNF IL1B IFNG
12 astrocyte activation GO:0048143 9.97 IFNG IL1B TNF
13 positive regulation of interleukin-6 production GO:0032755 9.96 TNF IL6 IL1B IFNG CYBA
14 positive regulation of neuroinflammatory response GO:0150078 9.93 TNF IL6 IL1B
15 positive regulation of chemokine production GO:0032722 9.91 TNF IL6 IL1B IFNG
16 positive regulation of fever generation GO:0031622 9.9 TNF IL1B
17 sequestering of triglyceride GO:0030730 9.88 TNF IL1B
18 negative regulation of lipid storage GO:0010888 9.88 TNF IL6 CRP
19 positive regulation of nitrogen compound metabolic process GO:0051173 9.87 TNF IFNG
20 positive regulation of vitamin D biosynthetic process GO:0060557 9.85 TNF IFNG
21 vascular endothelial growth factor production GO:0010573 9.8 IL1B IL6 TNF
22 superoxide anion generation GO:0042554 9.76 NCF4 NCF2 NCF1 CYBA
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IL1B IFNG
24 respiratory burst GO:0045730 9.23 NCF4 NCF2 NCF1 CYBA

Molecular functions related to Lung Abscess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 superoxide-generating NAD(P)H oxidase activity GO:0016175 9.43 NCF2 NCF1 CYBA
2 superoxide-generating NADPH oxidase activator activity GO:0016176 9.1 NCF4 NCF2 NCF1

Sources for Lung Abscess

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....