Aliases & Classifications for Lung Abscess

MalaCards integrated aliases for Lung Abscess:

Name: Lung Abscess 12 54 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060317
ICD9CM 34 513.0
MeSH 44 D008169
NCIt 50 C99090
SNOMED-CT 67 155618005
ICD10 32 J85.1 J85.2
UMLS 70 C0024110

Summaries for Lung Abscess

Disease Ontology : 12 A lung disease characterized by microbial infection which causes a type of liquefactive necrosis of the pulmonary tissue and formation of cavities containing necrotic debris or fluid.

MalaCards based summary : Lung Abscess is related to pleural empyema and aspiration pneumonia, and has symptoms including hemoptysis An important gene associated with Lung Abscess is LACTB (Lactamase Beta), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Ampicillin and Sulbactam have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and skin, and related phenotypes are cardiovascular system and cellular

Wikipedia : 73 Lung abscess is a type of liquefactive necrosis of the lung tissue and formation of cavities (more than... more...

Related Diseases for Lung Abscess

Diseases related to Lung Abscess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 780)
# Related Disease Score Top Affiliating Genes
1 pleural empyema 31.9 IL6 CRP CD4 ALB
2 aspiration pneumonia 31.6 TNF LACTB IL6 CRP ALB
3 aspergillosis 31.3 TNF IL6 IFNG
4 amebiasis 30.9 TNF CD4 ALB
5 bronchiectasis 30.8 TNF IL6 CRP
6 haemophilus influenzae 30.7 TNF LACTB
7 disseminated intravascular coagulation 30.2 TNF IL6 CRP
8 enterocolitis 30.1 TNF IL6
9 secondary syphilis 30.0 CRP CD4
10 respiratory failure 30.0 TNF IL6 CRP CD4 ALB
11 klebsiella pneumonia 30.0 TNF IL6 CRP CD4 ALB
12 aspiration pneumonitis 30.0 TNF CRP ALB
13 bronchitis 30.0 TNF LACTB IL6 CRP ALB
14 pneumonia 29.9 TNF LACTB IL6 IFNG CRP ALB
15 osteomyelitis 29.9 TNF IL6 IFNG CRP
16 infective endocarditis 29.9 TNF IL6 CRP
17 mediastinitis 29.9 LACTB CRP CD4 ALB
18 thrombocytosis 29.9 IL6 CRP ALB
19 neutropenia 29.8 TNF IL6 CRP ALB
20 actinomycosis 29.8 TNF IL6 CRP CD4 ALB
21 polyneuropathy 29.7 TNF IL6 CRP ALB
22 purpura 29.7 TNF IL6 IFNG CRP
23 uremia 29.7 TNF IL6 CRP ALB
24 toxic shock syndrome 29.7 TNF IL6 IFNG CRP
25 pulmonary tuberculosis 29.7 TNF IL6 IFNG ALB
26 end stage renal disease 29.7 TNF IL6 CRP ALB
27 melioidosis 29.6 TNF IL6 IFNG
28 gingivitis 29.6 TNF IL6 IFNG
29 colitis 29.6 TNF IL6 IFNG CD4
30 vasculitis 29.6 TNF PRTN3 IL6 CRP
31 bacterial pneumonia 29.5 TNF LACTB IL6 CRP CD4 ALB
32 pneumocystosis 29.5 TNF IL6 CRP CD4 ALB
33 pleural disease 29.5 TNF IL6 CRP CD4 ALB
34 bronchiolitis 29.5 TNF IL6 IFNG CRP
35 periodontitis 29.5 TNF IL6 IFNG CRP
36 candidiasis 29.5 TNF IL6 IFNG
37 pyelonephritis 29.4 TNF IL6 IFNG CRP ALB
38 echinococcosis 29.4 TNF IL6 IFNG
39 bacterial infectious disease 29.4 TNF IL6 IFNG CRP CD4
40 kidney disease 29.4 TNF PRTN3 IL6 CRP ALB
41 endocarditis 29.4 TNF LACTB IL6 IFNG CRP ALB
42 nocardiosis 29.4 TNF LACTB IFNG CRP CD4
43 mucormycosis 29.4 IFNG CRP CD4 ALB
44 lung disease 29.4 TNF PRTN3 IL6 IFNG CRP ALB
45 peritonitis 29.3 TNF PRTN3 IL6 CRP ALB
46 pemphigoid 29.3 TNF IFNG
47 salmonellosis 29.3 TNF LACTB IL6 IFNG CD4 ALB
48 tonsillitis 29.3 TNF LACTB IL6 IFNG
49 mycoplasma pneumoniae pneumonia 29.3 TNF IL6 IFNG CRP
50 leptospirosis 29.3 TNF IL6 IFNG CRP

Comorbidity relations with Lung Abscess via Phenotypic Disease Network (PDN):


Bronchiectasis Bronchitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Protein-Energy Malnutrition Respiratory Failure

Graphical network of the top 20 diseases related to Lung Abscess:



Diseases related to Lung Abscess

Symptoms & Phenotypes for Lung Abscess

UMLS symptoms related to Lung Abscess:


hemoptysis

MGI Mouse Phenotypes related to Lung Abscess:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 ALB CRP CYBA CYBB IFNG IL6
2 cellular MP:0005384 10.06 ALB CD4 CYBA CYBB DOCK8 IFNG
3 digestive/alimentary MP:0005381 9.86 ALB CD4 CYBA CYBB IFNG IL6
4 hematopoietic system MP:0005397 9.85 CD4 CYBA CYBB DOCK8 IFNG IL6
5 immune system MP:0005387 9.73 ALB CD4 CRP CYBA CYBB DOCK8
6 muscle MP:0005369 9.17 ALB CYBB IFNG IL6 JPH2 NCF1

Drugs & Therapeutics for Lung Abscess

Drugs for Lung Abscess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ampicillin Approved, Vet_approved Phase 3 69-53-4 6249
2
Sulbactam Approved Phase 3 68373-14-8
3
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
4
Polyestradiol phosphate Approved Phase 3 28014-46-2
5
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
6
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
7
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
8 Anti-Bacterial Agents Phase 3
9 Anti-Infective Agents Phase 3
10 beta-Lactamase Inhibitors Phase 3
11 Contraceptives, Oral Phase 3
12 Contraceptives, Oral, Combined Phase 3
13 Estradiol 17 beta-cypionate Phase 3
14 Estradiol 3-benzoate Phase 3
15 Contraceptive Agents Phase 3
16 Norgestimate, ethinyl estradiol drug combination Phase 3
17
Tetracycline Approved, Vet_approved 60-54-8 5353990
18
Azithromycin Approved 83905-01-5 447043 55185
19 Antibiotics, Antitubercular
20 Antibodies
21 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Multi-center, Randomized, Non-blind Trial to Assess the Efficacy and Safety of Moxifloxacin Versus Sulbactam/Ampicillin in the Treatment of Pulmonary Abscess and Aspiration Pneumonia Completed NCT01045902 Phase 3 Avelox (Moxifloxacin, BAY12-8039);Sulbactam/Ampicillin
2 Special Use-result Surveillance Of Unasyn-s (Kit) For Intravenous Use - A Surveillance On High-dose (>6 G Daily) Administration For Pneumonia, Lung Abscess And Peritonitis - Completed NCT01793688 Sulbactam Sodium/Ampicillin Sodium
3 Biomarkers for Diagnosis of Lung Nodules Active, not recruiting NCT01085864
4 Multi-center Investigation and Study of Mycoplasma Pneumoniae Infection and Macrolide Drug Resistance in Outpatient and In-hospital Pediatric Acute Respiratory Diseases Illness in China Not yet recruiting NCT04126304 Azithromycin;non-macrolides antibiotics

Search NIH Clinical Center for Lung Abscess

Cochrane evidence based reviews: lung abscess

Genetic Tests for Lung Abscess

Anatomical Context for Lung Abscess

MalaCards organs/tissues related to Lung Abscess:

40
Lung, Kidney, Skin, Trachea, Bone Marrow, Brain, Heart

Publications for Lung Abscess

Articles related to Lung Abscess:

(show top 50) (show all 1847)
# Title Authors PMID Year
1
Aspiration pneumonia and primary lung abscess: diagnosis and therapy of an aerobic or an anaerobic infection? 54 61
20477271 2007
2
Changing bacteriology of adult community-acquired lung abscess in Taiwan: Klebsiella pneumoniae versus anaerobes. 61 54
15824979 2005
3
[A comparative study of tazobactam/piperacillin and piperacillin in bacterial pneumonia]. 61 54
7783313 1995
4
To drain or not to drain? Abscess or empyema? 61
33177229 2021
5
Serratia marcescens Infection-Associated Loss of Vision: A Case Report in a Patient with a History of Intravenous Drug Use. 61
33649287 2021
6
Variation in Management and Outcomes of Children With Complicated Pneumonia. 61
33579749 2021
7
Lung abscess as a complication of COVID-19 infection, a case report. 61
33768796 2021
8
Analysis of risk factors for the development of a post-bronchoscopy respiratory infection in lung cancer patients. 61
33060045 2021
9
Unexpected Detection of Abscessualized Lung Carcinoma on Tc-99m-HMPAO-labeled Leukocytes Scintigraphy Misdiagnosed on Chest Computed Tomography. 61
33586412 2021
10
Candida Albicans Lung Abscess in an Illicit Drugs User With Hepatitis C Virus Chronic Infection. 61
33728135 2021
11
Detection of associated bacteria in aspiration pneumonia and lung abscesses using partial 16S rRNA gene amplicon sequencing. 61
33540111 2021
12
Eighteen years lasting bronchial foreign body: A case report in Cameroon, sub-Sahara Africa. 61
33486310 2021
13
Bulleidia extructa: An underappreciated anaerobic pathogen. 61
33596467 2021
14
Successful treatment of bilateral empyema with bilateral fistulae using free intercostal muscle flap. 61
33620526 2021
15
Identification and characterization of potential antioxidant components in Isodon amethystoides (Benth.) Hara tea leaves by UPLC-LTQ-Orbitrap-MS. 61
33385513 2021
16
A rare, but life-threatening sore throat: A case of Lemierre's syndrome. 61
33749697 2021
17
Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India. 61
33717137 2021
18
Accidental breakage of needle tip during endobronchial ultrasound-guided transbronchial needle aspiration: A case report and review of literature. 61
33402643 2021
19
Microwave ablation of lung malignancies with coexisting severe emphysema: a retrospective analysis of safety and efficacy in 26 patients. 61
33541162 2021
20
Recurrent Exacerbations of Chronic Obstructive Pulmonary Disease Reveal Swyer-James-MacLeod Syndrome in a 63-year-old Patient. 61
33585091 2021
21
Risk Factor Evaluation for Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa in Community-Acquired Pneumonia. 61
32545992 2021
22
A decade's experience of pediatric lung abscess and empyema at a community hospital. 61
33386780 2021
23
A Patient With AIRE Mutation Who Presented With Severe Diarrhea and Lung Abscess. 61
33284251 2021
24
Clinical Characteristics of Chronic Lung Abscess Associated with Parvimonas micra Diagnosed Using Metagenomic Next-Generation Sequencing. 61
33790589 2021
25
Contrast-enhanced ultrasound (CEUS) guided drainage in the treatment of a patient with lung abscess secondary to hypervirulent Klebsiella pneumoniae (hvKP) infection: A case report. 61
33614405 2021
26
Congenital bronchial atresia complicated by a lung abscess due to Aspergillus fumigatus: a case report. 61
33407289 2021
27
A recurrent lung abscess caused by delayed diagnosis of unique co-infection with Abiotrophia defectiva. 61
33155050 2020
28
Lung abscess due to Neisseria meningitidis serogroup X-unexpected virulence of a commensal resulting from putative serogroup B capsular switching. 61
32666483 2020
29
[Management of Lung Abscess - Diagnostics and Treatment]. 61
33260228 2020
30
Nocardiosis-an uncommon infection in patients with myasthenia gravis: report of three cases and review of literature. 61
33384345 2020
31
Postoperative cavitating infarction following lobectomy: the importance of variant pulmonary anatomy. 61
33298497 2020
32
A 28-Year-Old Pregnant Woman With a Lung Abscess and Complicated Pleural Effusion. 61
33160543 2020
33
A Case of Lung Abscess Caused by Double Immunosuppressive Therapy to Treat Ulcerative Colitis. 61
33171752 2020
34
[Organization integrated approach in treatment patients with aggravated comorbid background and lung abscess complicated by recurrent pulmonary bleeding]. 61
33219772 2020
35
Rare case of Prevotella pleuritidis lung abscess. 61
32900736 2020
36
Efficacy and safety of percutaneous tube drainage in lung abscess: a systematic review and meta-analysis. 61
32421402 2020
37
Intrapulmonary mature cystic teratoma of the lung: case report of a rare entity. 61
32928181 2020
38
Late Gastropleural Fistula after the Management of Laparoscopic Sleeve Gastrectomy Leakage. 61
32300947 2020
39
Complicated pneumonia in children. 61
32919518 2020
40
Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy. 61
32145245 2020
41
Risk Factors for Brain Abscess: A Nationwide, Population-Based, Nested Case-Control Study. 61
31641757 2020
42
A case of polymicrobial bacteremia due to lung abscess after respiratory syncytial virus infection. 61
32744365 2020
43
Left pulmonary artery pseudoaneurysm secondary to post-operative lung abscess. 61
32551122 2020
44
Accelerated hypofractionated radiotherapy with concurrent full dose chemotherapy for locally advanced non-small cell lung cancer: A phase I/II study. 61
32388152 2020
45
Esophagopulmonary fistula causing pulmonary arterial pseudoaneurysms and massive hemoptysis. 61
32382378 2020
46
Azygos Lobe: Prevalence of an Anatomical Variant and Its Recognition among Postgraduate Physicians. 61
32664403 2020
47
Pulmonary Artery Pseudoaneurysm Caused by Lung Abscess. 61
32014303 2020
48
Radiographic development and resolution of lung abscess. 61
32468940 2020
49
Lung abscess secondary to lung cancer with Eikenella corrodens and Streptococcus anginosus: a case report. 61
32423417 2020
50
Renal failure due to encrusted cystitis and pyelitis. 61
32743486 2020

Variations for Lung Abscess

Expression for Lung Abscess

Search GEO for disease gene expression data for Lung Abscess.

Pathways for Lung Abscess

Pathways related to Lung Abscess according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 TNF PRTN3 NCF2 NCF1 IL6 IFNG
2
Show member pathways
13.21 TNF NCF2 NCF1 IL6 CYBB CD4
3
Show member pathways
13.08 TNF NCF2 NCF1 IL6 IFNG CYBB
4
Show member pathways
12.71 TNF NCF2 NCF1 IL6 CYBB CYBA
5
Show member pathways
12.52 TNF IL6 IFNG CD4
6
Show member pathways
12.51 TNF IL6 IFNG CD4
7
Show member pathways
12.51 TNF IL6 IFNG CD4
8
Show member pathways
12.39 NCF2 NCF1 CYBB CYBA
9
Show member pathways
12.39 NCF2 NCF1 CYBB CYBA
10
Show member pathways
12.31 NCF2 NCF1 IL6 CYBB CYBA
11
Show member pathways
12.27 NCF2 NCF1 CYBB CYBA
12
Show member pathways
12.19 TNF IL6 IFNG CRP ALB
13 12.15 TNF IL6 CYBB CYBA
14 12.05 NCF2 NCF1 CYBB CYBA
15 11.98 NCF2 NCF1 CYBB CYBA
16 11.89 TNF IL6 IFNG CD4
17 11.88 IL6 IFNG CYBB
18 11.86 TNF NCF2 NCF1 IFNG CYBA
19 11.85 TNF IL6 IFNG
20 11.83 TNF IL6 CYBB
21 11.83 TNF IL6 CD4
22 11.8 TNF IL6 IFNG
23
Show member pathways
11.78 IL6 IFNG CD4
24
Show member pathways
11.76 NCF2 NCF1 CYBB CYBA
25 11.76 TNF NCF2 NCF1 IFNG CYBA
26 11.71 TNF IFNG CD4
27
Show member pathways
11.71 TNF NCF2 NCF1 IFNG CYBB CYBA
28
Show member pathways
11.61 TNF IL6 IFNG CD4
29
Show member pathways
11.59 TNF IL6 IFNG
30 11.57 TNF IL6 IFNG CD4
31 11.49 TNF IL6 IFNG
32 11.47 TNF IL6 IFNG
33 11.41 TNF IL6 IFNG
34
Show member pathways
11.41 NCF2 NCF1 CYBB CYBA
35 11.3 TNF IL6 IFNG
36 11.23 TNF IL6 IFNG
37 10.93 TNF IL6 CRP
38 10.92 TNF IL6 IFNG CD4
39 10.04 NCF2 NCF1 CYBB CYBA

GO Terms for Lung Abscess

Cellular components related to Lung Abscess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagolysosome GO:0032010 8.96 NCF2 NCF1
2 NADPH oxidase complex GO:0043020 8.92 NCF2 NCF1 CYBB CYBA

Biological processes related to Lung Abscess according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.03 NCF2 NCF1 CYBB CYBA CRP
2 inflammatory response GO:0006954 9.97 TNF IL6 CYBB CYBA CRP
3 cytokine-mediated signaling pathway GO:0019221 9.94 TNF PRTN3 IL6 CD4
4 defense response to Gram-positive bacterium GO:0050830 9.82 TNF IL6 CRP
5 positive regulation of tumor necrosis factor production GO:0032760 9.8 IL6 IFNG CYBA
6 regulation of insulin secretion GO:0050796 9.79 TNF IL6 IFNG
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 TNF IL6 IFNG
8 cellular response to oxidative stress GO:0034599 9.78 NCF2 NCF1 CYBB CYBA
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 TNF IL6 CYBA
10 humoral immune response GO:0006959 9.77 TNF IL6 IFNG
11 positive regulation of interleukin-1 beta production GO:0032731 9.76 TNF IL6 IFNG
12 positive regulation of interleukin-6 production GO:0032755 9.76 TNF IL6 IFNG CYBA
13 positive regulation of phagocytosis GO:0050766 9.75 TNF IFNG CYBA
14 positive regulation of chemokine production GO:0032722 9.73 TNF IL6 IFNG
15 electron transport chain GO:0022900 9.73 NCF2 NCF1 CYBB CYBA
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.71 NCF2 NCF1 CYBB CYBA
17 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.67 NCF2 NCF1 CYBB CYBA
18 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.65 TNF IL6
19 positive regulation of neuroinflammatory response GO:0150078 9.64 TNF IL6
20 negative regulation of amyloid-beta clearance GO:1900222 9.63 TNF IFNG
21 cell redox homeostasis GO:0045454 9.62 NCF2 NCF1 CYBB CYBA
22 vascular endothelial growth factor production GO:0010573 9.61 TNF IL6
23 cellular response to L-glutamine GO:1904845 9.55 CYBB CYBA
24 response to aldosterone GO:1904044 9.54 CYBB CYBA
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IFNG
26 positive regulation of vitamin D biosynthetic process GO:0060557 9.51 TNF IFNG
27 positive regulation of nitrogen compound metabolic process GO:0051173 9.49 TNF IFNG
28 superoxide metabolic process GO:0006801 9.46 NCF2 NCF1 CYBB CYBA
29 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
30 superoxide anion generation GO:0042554 9.26 NCF2 NCF1 CYBB CYBA
31 respiratory burst GO:0045730 8.92 NCF2 NCF1 CYBB CYBA

Molecular functions related to Lung Abscess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.26 NCF2 NCF1 CYBB CYBA
2 superoxide-generating NADPH oxidase activator activity GO:0016176 9.16 NCF2 NCF1
3 superoxide-generating NADPH oxidase activity GO:0016175 8.92 NCF2 NCF1 CYBB CYBA

Sources for Lung Abscess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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