Aliases & Classifications for Lung Abscess

MalaCards integrated aliases for Lung Abscess:

Name: Lung Abscess 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060317
ICD9CM 34 513.0
MeSH 43 D008169
NCIt 49 C99090
SNOMED-CT 67 73452002
ICD10 32 J85.1 J85.2
UMLS 71 C0024110

Summaries for Lung Abscess

Disease Ontology : 12 A lung disease characterized by microbial infection which causes a type of liquefactive necrosis of the pulmonary tissue and formation of cavities containing necrotic debris or fluid.

MalaCards based summary : Lung Abscess is related to pleural empyema and aspiration pneumonia, and has symptoms including hemoptysis An important gene associated with Lung Abscess is LACTB (Lactamase Beta), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Ampicillin and Sulbactam have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Lung abscess is a type of liquefactive necrosis of the lung tissue and formation of cavities (more than... more...

Related Diseases for Lung Abscess

Diseases related to Lung Abscess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 909)
# Related Disease Score Top Affiliating Genes
1 pleural empyema 32.4 FLNC CRP CD40LG CD4 ALB
2 aspiration pneumonia 32.3 LACTB IL6 CRP CD40LG ALB
3 anaerobic pneumonia 31.8 TNF IL6 IL1B
4 aspergillosis 31.4 TNF STAT3 IL6 IL1B IFNG
5 amebiasis 30.9 TNF IL1B CD40LG CD4 ALB
6 haemophilus influenzae 30.7 TNF LACTB
7 mediastinitis 30.5 LACTB CRP ALB
8 klebsiella pneumonia 30.4 LACTB CRP CD40LG ALB
9 actinomycosis 30.4 CRP CD4 ALB
10 infective endocarditis 30.3 TNF IL6 CRP
11 bronchiectasis 30.3 TNF IL1B CRP
12 pulmonary embolism 30.2 CRP CD40LG ALB
13 allergic bronchopulmonary aspergillosis 30.2 IGES IFNG FLNC
14 disseminated intravascular coagulation 30.2 TNF IL6 CRP
15 epidural abscess 30.0 CRP ALB
16 aspiration pneumonitis 30.0 TNF CRP ALB
17 pure red-cell aplasia 30.0 STAT3 CD40LG ALB
18 coccidioidomycosis 30.0 TNF CD40LG CD4
19 thrombophlebitis 30.0 TNF CRP CD40LG ALB
20 legionellosis 29.7 TNF IL6 IL1B CD40LG
21 melioidosis 29.7 TNF IL6 IFNG
22 invasive aspergillosis 29.7 IFNG FLNC CD4
23 osteomyelitis 29.7 TNF IL6 IL1B IFNG
24 diverticulitis 29.6 TNF IL6 CRP ALB
25 endocarditis 29.6 TNF LACTB IL6 IFNG CRP ALB
26 acute kidney tubular necrosis 29.6 TNF IL6 CD40LG ALB
27 uremia 29.6 TNF IL6 CRP ALB
28 end stage renal disease 29.6 TNF IL6 CRP ALB
29 pulmonary edema 29.6 TNF IL1B CRP
30 peptic ulcer disease 29.5 TNF IL1B ALB
31 autoimmune hepatitis 29.5 TNF IL6 CD40LG ALB
32 mucormycosis 29.5 IFNG FLNC CRP CD4
33 deficiency anemia 29.5 TNF IL6 CRP ALB
34 pemphigus 29.5 TNF IL6 CD40LG
35 seborrheic dermatitis 29.5 TNF DOCK8 CD4
36 mycobacterium tuberculosis 1 29.5 TNF IFNG HSPE1 CRP CD4
37 nocardiosis 29.4 TNF LACTB IFNG CRP CD4
38 purpura 29.4 TNF IL6 IFNG CRP CD40LG
39 histoplasmosis 29.4 TNF IFNG CD40LG CD4
40 thrombocytosis 29.3 IL6 IL1B CRP ALB
41 sickle cell anemia 29.3 TNF IL6 CRP CD40LG ALB
42 encephalitis 29.3 TNF IL6 IL1B CD40LG
43 bronchiolitis obliterans 29.3 TNF IL6 IFNG CRP
44 spondylitis 29.3 TNF IL6 IFNG CRP
45 glomerulonephritis 29.3 PRTN3 IL1B CD40LG ALB
46 echinococcosis 29.3 TNF IL6 IFNG CD40LG
47 bronchiolitis 29.3 TNF IL6 IFNG CRP CD40LG
48 gingivitis 29.2 TNF IL6 IL1B IFNG
49 vasculitis 29.2 TNF PRTN3 IL6 CRP CD40LG
50 pneumonia 29.1 TNF LACTB IL6 IL1B IFNG CRP

Comorbidity relations with Lung Abscess via Phenotypic Disease Network (PDN):


Bronchiectasis Bronchitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Protein-Energy Malnutrition Respiratory Failure

Graphical network of the top 20 diseases related to Lung Abscess:



Diseases related to Lung Abscess

Symptoms & Phenotypes for Lung Abscess

UMLS symptoms related to Lung Abscess:


hemoptysis

MGI Mouse Phenotypes related to Lung Abscess:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ALB CD40LG CRP FLNC IFNG IL1B
2 homeostasis/metabolism MP:0005376 10.03 ALB CD4 CD40LG CRP FLNC IFNG
3 hematopoietic system MP:0005397 10.02 CD4 CD40LG DOCK8 IFNG IL1B IL6
4 immune system MP:0005387 9.93 ALB CD4 CD40LG CRP DOCK8 IFNG
5 integument MP:0010771 9.56 CD4 CD40LG FLNC IFNG IL1B IL6
6 muscle MP:0005369 9.17 ALB FLNC IFNG IL6 JPH2 STAT3

Drugs & Therapeutics for Lung Abscess

Drugs for Lung Abscess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ampicillin Approved, Vet_approved Phase 3 69-53-4 6249
2
Sulbactam Approved Phase 3 68373-14-8
3
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
4
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
5
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
6
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
7
Polyestradiol phosphate Approved Phase 3 28014-46-2
8 Estradiol 17 beta-cypionate Phase 3
9 Contraceptives, Oral, Combined Phase 3
10 Contraceptives, Oral Phase 3
11 Estradiol 3-benzoate Phase 3
12 Contraceptive Agents Phase 3
13 Norgestimate, ethinyl estradiol drug combination Phase 3
14 beta-Lactamase Inhibitors Phase 3
15
Sultamicillin Approved, Investigational 76497-13-7
16
Tetracycline Approved, Vet_approved 60-54-8 5353990
17
Azithromycin Approved 83905-01-5 447043 55185
18 Fluorodeoxyglucose F18
19 Anti-Infective Agents
20 Anti-Bacterial Agents
21 Immunoglobulins
22 Antibodies
23 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Multi-center, Randomized, Non-blind Trial to Assess the Efficacy and Safety of Moxifloxacin Versus Sulbactam/Ampicillin in the Treatment of Pulmonary Abscess and Aspiration Pneumonia Completed NCT01045902 Phase 3 Avelox (Moxifloxacin, BAY12-8039);Sulbactam/Ampicillin
2 Diagnosis of Invasive Pulmonary Aspergillosis by Direct Lung Tissue Aspergillus Galactomannan Antigen Detection From Aspirate by Ultrasound-guided Fine Needle Aspiration Unknown status NCT01301755
3 Special Use-result Surveillance Of Unasyn-s (Kit) For Intravenous Use - A Surveillance On High-dose (>6 G Daily) Administration For Pneumonia, Lung Abscess And Peritonitis ‐ Completed NCT01793688 Sulbactam Sodium/Ampicillin Sodium
4 Cost-consequence Analysis of Parenchymal Stapling Device Versus Hand-sewing for Pulmonary Lobectomy in Lung Disease: A Randomized Controlled Trial Completed NCT01575314
5 Biomarkers for Diagnosis of Lung Nodules Active, not recruiting NCT01085864
6 FDG-PET Imaging in Complicated Diabetic Foot (Protocol Version Dated 3/01/2004) Active, not recruiting NCT00194298
7 Multi-center Investigation and Study of Mycoplasma Pneumoniae Infection and Macrolide Drug Resistance in Outpatient and In-hospital Pediatric Acute Respiratory Diseases Illness in China Not yet recruiting NCT04126304 Azithromycin;non-macrolides antibiotics

Search NIH Clinical Center for Lung Abscess

Cochrane evidence based reviews: lung abscess

Genetic Tests for Lung Abscess

Anatomical Context for Lung Abscess

MalaCards organs/tissues related to Lung Abscess:

40
Lung, Liver, Brain, Heart, Bone, Kidney, Neutrophil

Publications for Lung Abscess

Articles related to Lung Abscess:

(show top 50) (show all 1757)
# Title Authors PMID Year
1
Aspiration pneumonia and primary lung abscess: diagnosis and therapy of an aerobic or an anaerobic infection? 61 54
20477271 2007
2
Changing bacteriology of adult community-acquired lung abscess in Taiwan: Klebsiella pneumoniae versus anaerobes. 54 61
15824979 2005
3
[A comparative study of tazobactam/piperacillin and piperacillin in bacterial pneumonia]. 61 54
7783313 1995
4
Left pulmonary artery pseudoaneurysm secondary to post-operative lung abscess. 61
32551122 2020
5
Esophagopulmonary fistula causing pulmonary arterial pseudoaneurysms and massive hemoptysis. 61
32382378 2020
6
Pulmonary Artery Pseudoaneurysm Caused by Lung Abscess. 61
32014303 2020
7
Risk Factor Evaluation for Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa in Community-Acquired Pneumonia. 61
32545992 2020
8
Radiographic development and resolution of lung abscess. 61
32468940 2020
9
Lung abscess secondary to lung cancer with Eikenella corrodens and Streptococcus anginosus: a case report. 61
32423417 2020
10
Efficacy and safety of percutaneous tube drainage in lung abscess: a systematic review and meta-analysis. 61
32421402 2020
11
Evaluation of endobronchial volatile sulfur compounds for rapid diagnosis of lung abscesses caused by obligate anaerobes using Oral Chroma™: A pilot study. 61
32171700 2020
12
Effective exchange to a larger size catheter for a lung abscess with initial percutaneous drainage failure: a case report. 61
32246299 2020
13
Accelerated hypofractionated radiotherapy with concurrent full dose chemotherapy for locally advanced non-small cell lung cancer: A phase I/II study. 61
32388152 2020
14
Slowly or Nonresolving Legionnaires' Disease: Case Series and Literature Review. 61
31242293 2020
15
Late Gastropleural Fistula after the Management of Laparoscopic Sleeve Gastrectomy Leakage. 61
32300947 2020
16
Trauma-Associated Pulmonary Laceration in Dogs-A Cross Sectional Study of 364 Dogs. 61
32290621 2020
17
Enterococcus faecalis-associated lung abscess in a male adolescent- a case report. 61
32122323 2020
18
Percutaneous lung abscess drainage: revisiting the old gold standard. 61
32138472 2020
19
Chitinophaga vietnamensis sp. nov., a multi-drug resistant bacterium infecting humans. 61
32228771 2020
20
[Overlooked deadly infection with Coccidioides immitis]. 61
32285777 2020
21
Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy. 61
32145245 2020
22
Comparison between Patients with Chest Infection due to Klebsiella spp. and Streptococcus pneumoniae. 61
31761885 2020
23
RFA of primary and metastatic lung tumors: long-term results. 61
32219567 2020
24
Endoscopic Treatment and Pulmonary Rehabilitation for Management of Lung Abscess in Elderly Lymphoma Patients. 61
32033391 2020
25
Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer. 61
32273634 2020
26
Staphylococcal lung abscess in a child with cystic fibrosis: Case report & review of literature. 61
32099785 2020
27
Effective pharmacotherapy for lung abscess in a patient with alcoholism. 61
32373455 2020
28
Mucor pulmonary embolism in a patient with myelodysplastic syndrome. 61
32190545 2020
29
Antibiotic instillation for a chronic lung abscess. 61
31908918 2020
30
Severe Pneumonia Advanced to Lung Abscess and Empyema Due to Rothia Mucilaginosa in an Immunocompetent Patient. 61
31785769 2020
31
Lung abscess and empyema following bronchoscopy: A case report and review of the literature. 61
32566475 2020
32
The value of chest magnetic resonance imaging compared to chest radiographs with and without additional lung ultrasound in children with complicated pneumonia. 61
32191736 2020
33
Ambulatory drainage and management of a pleural empyema. 61
32226957 2020
34
Mechanical insufflation-exsufflation-related bilateral pneumothorax. 61
32071855 2020
35
A Rare Case of Bronchopulmonary Sequestration Masquerading as Lung Abscess. 61
31451182 2019
36
Osler Centenary Papers: Management of pleural infection: Osler's final illness and recent advances. 61
31754057 2019
37
Concomitance of pulmonary spindle cell carcinoma and sclerosing pneumocytoma in a woman: A case report. 61
31861007 2019
38
Therapeutic bronchoscopy in a lung abscess secondary to broncholithiasis. 61
31523432 2019
39
Pulmonary sequestration mimicking lung abscess in old age. 61
30117665 2019
40
Risk Factors for Brain Abscess: A Nationwide, Population-Based, Nested Case-Control Study. 61
31641757 2019
41
Postobstructive pneumonia in lung cancer. 61
31516903 2019
42
Lung abscess by Actinomyces odontolyticus and Parvimonas micra co-infection presenting as acute respiratory failure: A case report. 61
31464925 2019
43
Predictive value of Thomsen-Friedenreich antigen activation for Streptococcus pneumoniae infection and severity in pediatric lobar pneumonia. 61
28918242 2019
44
A lung abscess caused by secondary syphilis - the utility of polymerase chain reaction techniques in transbronchial biopsy: a case report. 61
31288744 2019
45
Lung abscess in an immunocompromised patient: clinical presentation and management challenges. 61
31315847 2019
46
Infantile osteomyelitis of the fourth rib causing the occurrence of a lung abscess. 61
31360480 2019
47
[Lung abscess: Diagnosis and management]. 61
31202603 2019
48
Giant lung cysts following necrotizing pneumonia: Resolution with conservative treatment. 61
30897292 2019
49
Acquired reversible Brown syndrome caused by focal abscess of the superior oblique muscle. 61
30710645 2019
50
Percutaneous Bronchial Embolization to Treat Intractable Bronchobiliary Fistula. 61
30684010 2019

Variations for Lung Abscess

Expression for Lung Abscess

Search GEO for disease gene expression data for Lung Abscess.

Pathways for Lung Abscess

Pathways related to Lung Abscess according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 TNF STAT3 PRTN3 IL6 IL1B IFNG
2
Show member pathways
13.3 TNF NCF2 IL6 IL1B FLNC CD40LG
3
Show member pathways
12.85 TNF IL6 IL1B IFNG CD40LG CD4
4
Show member pathways
12.81 TNF STAT3 IL6 IL1B IFNG
5
Show member pathways
12.64 TNF STAT3 IL1B IFNG CD40LG CD4
6 12.57 TNF STAT3 IL1B IFNG CD40LG
7
Show member pathways
12.57 TNF STAT3 IL6 IL1B IFNG CD4
8
Show member pathways
12.56 TNF STAT3 IL6 IL1B IFNG CD4
9
Show member pathways
12.45 TNF STAT3 IL6 IL1B IFNG CD40LG
10 12.32 TNF IL6 IL1B FLNC
11
Show member pathways
12.32 TNF STAT3 IL6 IL1B IFNG
12
Show member pathways
12.31 TNF IL6 IL1B IFNG
13
Show member pathways
12.27 TNF IL6 IL1B IFNG CRP ALB
14 12.25 TNF IL6 IL1B IFNG
15
Show member pathways
12.21 TNF STAT3 IL1B IFNG
16 12.19 TNF STAT3 IL6 IFNG
17
Show member pathways
12.19 TNF IL6 IL1B IFNG
18
Show member pathways
12.16 TNF STAT3 NCF2 IL1B IFNG CD40LG
19 12.11 TNF NCF2 IL1B IFNG
20 12.07 TNF NCF2 IL1B IFNG
21 12.03 TNF IL6 IL1B IFNG
22 12.01 TNF IL6 IFNG CD4
23 12 TNF STAT3 IL6 IL1B
24
Show member pathways
11.99 STAT3 IL1B IFNG CD4
25 11.93 TNF IL6 IL1B IFNG
26 11.91 TNF STAT3 IL6 IL1B
27 11.9 TNF IL6 IL1B CD4
28 11.87 TNF IL6 IL1B IFNG
29
Show member pathways
11.86 STAT3 IL1B IFNG
30
Show member pathways
11.83 STAT3 IL6 CRP
31
Show member pathways
11.79 STAT3 IL6 IL1B IFNG CD4
32 11.78 TNF IL1B IFNG CD4
33 11.77 TNF IL6 IL1B
34
Show member pathways
11.76 TNF IFNG CD40LG
35 11.68 TNF IL6 IL1B
36 11.64 TNF STAT3 IFNG
37 11.63 TNF IL6 IL1B
38 11.59 TNF IL6 IL1B IFNG CD4
39 11.58 TNF IL6 IFNG
40 11.54 TNF IL1B IFNG
41 11.54 TNF IL1B IFNG
42 11.53 TNF STAT3 IL6 IL1B
43 11.48 TNF IL6 IL1B IFNG
44
Show member pathways
11.46 TNF STAT3 IL6 IL1B IFNG CD4
45
Show member pathways
11.45 TNF IL6 IL1B IFNG CD40LG
46 11.38 TNF IL6 IL1B IFNG
47 11.34 TNF STAT3 IL6 IL1B
48 11.32 TNF IL6 IL1B
49 11.28 TNF IL6 IL1B IFNG
50 11.27 STAT3 IFNG CD4

GO Terms for Lung Abscess

Cellular components related to Lung Abscess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNF PRTN3 IL6 IL1B IFNG CRP

Biological processes related to Lung Abscess according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.07 STAT3 PRTN3 IL6 IL1B IFNG
2 immune response GO:0006955 10.03 TNF IL6 IL1B IFNG CD40LG CD4
3 positive regulation of gene expression GO:0010628 10.02 TNF STAT3 IL6 IL1B IFNG CRP
4 positive regulation of protein phosphorylation GO:0001934 9.94 TNF IL1B IFNG CD4
5 inflammatory response GO:0006954 9.93 TNF STAT3 IL6 IL1B CRP CD40LG
6 positive regulation of inflammatory response GO:0050729 9.85 TNF IL1B IFNG
7 regulation of insulin secretion GO:0050796 9.84 TNF IL1B IFNG
8 cellular response to organic cyclic compound GO:0071407 9.83 TNF STAT3 IL1B
9 humoral immune response GO:0006959 9.83 TNF IL6 IFNG
10 positive regulation of interleukin-6 production GO:0032755 9.81 TNF IL6 IL1B
11 positive regulation of phagocytosis GO:0050766 9.8 TNF IL1B IFNG
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 TNF IL1B IFNG
13 positive regulation of interleukin-6 secretion GO:2000778 9.78 TNF IL1B IFNG
14 acute-phase response GO:0006953 9.77 STAT3 IL6 CRP
15 negative regulation of neurogenesis GO:0050768 9.76 TNF IL6 IL1B
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 TNF STAT3 IL6 IFNG
17 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 TNF STAT3 IL6
18 positive regulation of glial cell proliferation GO:0060252 9.7 TNF IL6 IL1B
19 astrocyte activation GO:0048143 9.69 TNF IL1B IFNG
20 interleukin-15-mediated signaling pathway GO:0035723 9.68 STAT3 CD4
21 negative regulation of amyloid-beta clearance GO:1900222 9.67 TNF IFNG
22 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.67 TNF IFNG
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 TNF IL1B IFNG
24 positive regulation of T cell proliferation GO:0042102 9.67 IL6 IL1B CD40LG CD4
25 regulation of establishment of endothelial barrier GO:1903140 9.65 TNF IL1B
26 T-helper 17 cell lineage commitment GO:0072540 9.65 STAT3 IL6
27 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.65 TNF STAT3 IL1B
28 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 TNF STAT3 IL6 IL1B CD40LG
29 regulation of immunoglobulin secretion GO:0051023 9.63 TNF CD40LG
30 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
31 sequestering of triglyceride GO:0030730 9.62 TNF IL1B
32 negative regulation of primary miRNA processing GO:2000635 9.59 STAT3 IL6
33 positive regulation of vitamin D biosynthetic process GO:0060557 9.58 TNF IFNG
34 positive regulation of chemokine biosynthetic process GO:0045080 9.58 TNF IL1B IFNG
35 positive regulation of nitrogen compound metabolic process GO:0051173 9.57 TNF IFNG
36 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
37 cytokine-mediated signaling pathway GO:0019221 9.43 TNF STAT3 PRTN3 IL6 IL1B CD4
38 negative regulation of lipid storage GO:0010888 9.33 TNF IL6 CRP
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 TNF IL1B IFNG

Molecular functions related to Lung Abscess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IFNG CD40LG

Sources for Lung Abscess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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