Lung Acinar Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lung Acinar Adenocarcinoma

MalaCards integrated aliases for Lung Acinar Adenocarcinoma:

Name: Lung Acinar Adenocarcinoma ¹² ¹⁵

Acinar Adenocarcinoma of the Lung ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6482

NCIt ⁵⁰ C5649

UMLS ⁷³ C1332137

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Summaries for Lung Acinar Adenocarcinoma

MalaCards based summary : Lung Acinar Adenocarcinoma, also known as acinar adenocarcinoma of the lung, is related to colloid adenoma and rete testis adenocarcinoma. An important gene associated with Lung Acinar Adenocarcinoma is TNKS (Tankyrase), and among its related pathways/superpathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Regulation of Telomerase. Affiliated tissues include lung, kidney and colon.

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Related Diseases for Lung Acinar Adenocarcinoma

Diseases related to Lung Acinar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)

#	Related Disease	Score	Top Affiliating Genes
1	colloid adenoma	10.2	KRT20 NKX2-1
2	rete testis adenocarcinoma	10.2	KRT20 NKX2-1
3	rete testis neoplasm	10.1	KRT20 NKX2-1
4	goblet cell carcinoid	10.1	CTNNB1 KRT20
5	signet ring cell adenocarcinoma	10.1	KRT20 KRT7
6	cystic basal cell carcinoma	10.1	KRT20 KRT7
7	seminal vesicle adenocarcinoma	10.1	KRT20 KRT7
8	transverse colon cancer	10.1	KRT20 KRT7
9	appendix adenocarcinoma	10.1	KRT20 KRT7
10	malignant syringoma	10.1	KRT20 KRT7
11	glandular cystitis	10.1	KRT20 KRT7
12	papillary transitional carcinoma	10.1	KRT20 KRT7
13	eyelid carcinoma	10.1	KRT20 KRT7
14	krukenberg carcinoma	10.1	KRT20 KRT7
15	linitis plastica	10.1	KRT20 KRT7
16	adenoid squamous cell carcinoma	10.1	KRT20 KRT7
17	intratubular embryonal carcinoma	10.1	KRT20 KRT7
18	vulval paget's disease	10.1	KRT20 KRT7
19	bile duct cystadenocarcinoma	10.1	KRT20 KRT7
20	bile duct adenoma	10.1	KRT20 KRT7
21	jejunal adenocarcinoma	10.1	KRT20 KRT7
22	teratoma	10.1	KRT7 NKX2-1
23	ovarian mucinous adenocarcinoma	10.1	KRT20 KRT7
24	thymus adenocarcinoma	10.1	KRT20 KRT7
25	appendix disease	10.1	KRT20 KRT7
26	gastric diffuse adenocarcinoma	10.1	KRT20 KRT7
27	meibomian cyst	10.1	KRT20 KRT7
28	bladder lymphoma	10.1	KRT20 KRT7
29	chronic cystitis	10.1	KRT20 KRT7
30	vulva adenocarcinoma	10.1	KRT20 KRT7
31	medulloepithelioma	10.1	KRT20 KRT7
32	glycogen-rich clear cell breast carcinoma	10.1	KRT20 KRT7
33	rectum adenocarcinoma	10.1	KRT20 KRT7
34	solid adenocarcinoma with mucin production	10.1	KRT7 NKX2-1
35	renal pelvis carcinoma	10.1	KRT20 KRT7
36	ovarian germ cell teratoma	10.1	KRT7 NKX2-1
37	paget disease, extramammary	10.1	KRT20 KRT7
38	ovarian germ cell cancer	10.1	KRT7 NKX2-1
39	ampulla of vater adenocarcinoma	10.1	KRT20 KRT7
40	biliary papillomatosis	10.1	KRT20 KRT7
41	papillary adenoma	10.1	KRT7 NKX2-1
42	lymphoepithelioma-like carcinoma	10.1	KRT20 KRT7
43	endocervical adenocarcinoma	10.1	KRT20 KRT7
44	cervical adenocarcinoma	10.1	KRT20 KRT7
45	eccrine sweat gland neoplasm	10.1	KRT20 KRT7
46	dermoid cyst	10.1	KRT20 KRT7
47	infiltrative basal cell carcinoma	10.1	KRT20 KRT7
48	cystadenofibroma	10.1	KRT20 KRT7
49	ovarian mucinous neoplasm	10.1	KRT20 KRT7
50	intestinal perforation	10.1	KRT7 NKX2-1

Graphical network of the top 20 diseases related to Lung Acinar Adenocarcinoma:

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Symptoms & Phenotypes for Lung Acinar Adenocarcinoma

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Drugs & Therapeutics for Lung Acinar Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Lung Acinar Adenocarcinoma

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Genetic Tests for Lung Acinar Adenocarcinoma

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Anatomical Context for Lung Acinar Adenocarcinoma

MalaCards organs/tissues related to Lung Acinar Adenocarcinoma:

⁴¹

Lung, Kidney, Colon, Thyroid, Testis, Thymus, Appendix

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Publications for Lung Acinar Adenocarcinoma

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Genes for Lung Acinar Adenocarcinoma

Genes related to Lung Acinar Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TNKS	Tankyrase	Protein Coding	15.98	DISEASES inferred ¹⁵
2	KRT20	Keratin 20	Protein Coding	14.69	DISEASES inferred ¹⁵
3	NKX2-1	NK2 Homeobox 1	Protein Coding	14.55	DISEASES inferred ¹⁵
4	CTNNB1	Catenin Beta 1	Protein Coding	14.21	DISEASES inferred ¹⁵
5	KRT7	Keratin 7	Protein Coding	14.07	DISEASES inferred ¹⁵
6	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	13.2	DISEASES inferred ¹⁵
7	LGALS4	Galectin 4	Protein Coding	5.12	DISEASES inferred ¹⁵

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Variations for Lung Acinar Adenocarcinoma

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Expression for Lung Acinar Adenocarcinoma

Search GEO for disease gene expression data for Lung Acinar Adenocarcinoma.

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Pathways for Lung Acinar Adenocarcinoma

Pathways related to Lung Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Association Between Physico-Chemical Features and Toxicity Associated Pathways ¹	11.2	CTNNB1 MYC
2	Regulation of Telomerase ¹	11.14	MYC TNKS
3	Wnt Signaling Pathway Netpath ¹	10.98	CTNNB1 MYC
4	Presenilin action in Notch and Wnt signaling ¹	10.82	CTNNB1 MYC
5	Gastric Cancer Network 2 ¹	10.47	CTNNB1 MYC
6	Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds ¹	9.88	CTNNB1 TNKS

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GO Terms for Lung Acinar Adenocarcinoma

Biological processes related to Lung Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.71	CTNNB1 MYC NKX2-1 TNKS
2	positive regulation of gene expression	GO:0010628	9.61	CTNNB1 MYC NKX2-1
3	forebrain development	GO:0030900	9.46	CTNNB1 NKX2-1
4	branching involved in ureteric bud morphogenesis	GO:0001658	9.37	CTNNB1 MYC
5	positive regulation of telomere maintenance via telomerase	GO:0032212	9.32	CTNNB1 TNKS
6	beta-catenin-TCF complex assembly	GO:1904837	9.26	CTNNB1 MYC
7	positive regulation of mesenchymal cell proliferation	GO:0002053	9.16	CTNNB1 MYC
8	epithelial tube branching involved in lung morphogenesis	GO:0060441	8.96	CTNNB1 NKX2-1
9	positive regulation of telomerase activity	GO:0051973	8.8	CTNNB1 MYC TNKS

Molecular functions related to Lung Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	repressing transcription factor binding	GO:0070491	8.62	CTNNB1 MYC

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Sources for Lung Acinar Adenocarcinoma

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