Lung Acinar Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lung Acinar Adenocarcinoma

MalaCards integrated aliases for Lung Acinar Adenocarcinoma:

Name: Lung Acinar Adenocarcinoma ¹² ¹⁵

Acinar Adenocarcinoma of the Lung ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6482

NCIt ⁵⁰ C5649

UMLS ⁷³ C1332137

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Summaries for Lung Acinar Adenocarcinoma

MalaCards based summary : Lung Acinar Adenocarcinoma, also known as acinar adenocarcinoma of the lung, is related to rete testis adenocarcinoma and rete testis neoplasm. An important gene associated with Lung Acinar Adenocarcinoma is TNKS (Tankyrase), and among its related pathways/superpathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Regulation of Telomerase. Affiliated tissues include lung.

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Related Diseases for Lung Acinar Adenocarcinoma

Diseases related to Lung Acinar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)

#	Related Disease	Score	Top Affiliating Genes
1	rete testis adenocarcinoma	10.5	KRT20 NKX2-1
2	rete testis neoplasm	10.4	KRT20 NKX2-1
3	goblet cell carcinoid	10.4	CTNNB1 KRT20
4	cystic basal cell carcinoma	10.3	KRT20 KRT7
5	vaginal benign neoplasm	10.3	KRT20 KRT7
6	seminal vesicle adenocarcinoma	10.3	KRT20 KRT7
7	transverse colon cancer	10.3	KRT20 KRT7
8	appendix adenocarcinoma	10.3	KRT20 KRT7
9	ovarian large-cell neuroendocrine carcinoma	10.3	KRT20 KRT7
10	vaginal adenoma	10.3	KRT20 KRT7
11	vaginal tubulovillous adenoma	10.3	KRT20 KRT7
12	eyelid neoplasm	10.3	KRT20 KRT7
13	glandular cystitis	10.3	KRT20 KRT7
14	malignant syringoma	10.3	KRT20 KRT7
15	krukenberg carcinoma	10.3	KRT20 KRT7
16	linitis plastica	10.3	KRT20 KRT7
17	adenoid squamous cell carcinoma	10.3	KRT20 KRT7
18	eccrine sweat gland neoplasm	10.3	KRT20 KRT7
19	vulval paget's disease	10.3	KRT20 KRT7
20	bile duct cystadenocarcinoma	10.3	KRT20 KRT7
21	intratubular embryonal carcinoma	10.3	KRT20 KRT7
22	ovarian mucinous adenocarcinoma	10.3	KRT20 KRT7
23	thymus adenocarcinoma	10.3	KRT20 KRT7
24	gastric diffuse adenocarcinoma	10.3	KRT20 KRT7
25	meibomian cyst	10.3	KRT20 KRT7
26	bladder lymphoma	10.3	KRT20 KRT7
27	jejunal adenocarcinoma	10.3	KRT20 KRT7
28	chronic cystitis	10.3	KRT20 KRT7
29	solid adenocarcinoma with mucin production	10.3	KRT7 NKX2-1
30	vulva adenocarcinoma	10.3	KRT20 KRT7
31	medulloepithelioma	10.3	KRT20 KRT7
32	glycogen-rich clear cell breast carcinoma	10.3	KRT20 KRT7
33	rectum adenocarcinoma	10.3	KRT20 KRT7
34	renal pelvis carcinoma	10.3	KRT20 KRT7
35	paget disease, extramammary	10.3	KRT20 KRT7
36	ovarian germ cell teratoma	10.3	KRT7 NKX2-1
37	ampulla of vater neoplasm	10.3	KRT20 KRT7
38	ovarian germ cell cancer	10.3	KRT7 NKX2-1
39	appendix cancer	10.3	KRT20 KRT7
40	ampulla of vater adenocarcinoma	10.3	KRT20 KRT7
41	mucinous cystadenocarcinoma	10.3	KRT20 KRT7
42	papillary adenoma	10.2	KRT7 NKX2-1
43	biliary papillomatosis	10.2	KRT20 KRT7
44	bronchiolo-alveolar adenocarcinoma	10.2	KRT7 NKX2-1
45	lymphoepithelioma-like carcinoma	10.2	KRT20 KRT7
46	endocervical adenocarcinoma	10.2	KRT20 KRT7
47	dermoid cyst	10.2	KRT20 KRT7
48	infiltrative basal cell carcinoma	10.2	KRT20 KRT7
49	intestinal perforation	10.2	KRT7 NKX2-1
50	immune system organ benign neoplasm	10.2	KRT20 KRT7

Graphical network of the top 20 diseases related to Lung Acinar Adenocarcinoma:

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Symptoms & Phenotypes for Lung Acinar Adenocarcinoma

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Drugs & Therapeutics for Lung Acinar Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Lung Acinar Adenocarcinoma

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Genetic Tests for Lung Acinar Adenocarcinoma

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Anatomical Context for Lung Acinar Adenocarcinoma

MalaCards organs/tissues related to Lung Acinar Adenocarcinoma:

⁴¹

Lung

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Publications for Lung Acinar Adenocarcinoma

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Genes for Lung Acinar Adenocarcinoma

Genes related to Lung Acinar Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TNKS	Tankyrase	Protein Coding	16.1	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	KRT20	Keratin 20	Protein Coding	14.85	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	NKX2-1	NK2 Homeobox 1	Protein Coding	14.72	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	CTNNB1	Catenin Beta 1	Protein Coding	14.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	KRT7	Keratin 7	Protein Coding	14.24	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	13.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	LGALS4	Galectin 4	Protein Coding	5.25	DISEASES inferred ¹⁵

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Variations for Lung Acinar Adenocarcinoma

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Expression for Lung Acinar Adenocarcinoma

Search GEO for disease gene expression data for Lung Acinar Adenocarcinoma.

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Pathways for Lung Acinar Adenocarcinoma

Pathways related to Lung Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Association Between Physico-Chemical Features and Toxicity Associated Pathways ¹	11.2	CTNNB1 MYC
2	Regulation of Telomerase ¹	11.14	MYC TNKS
3	Wnt Signaling Pathway Netpath ¹	10.98	CTNNB1 MYC
4	Presenilin action in Notch and Wnt signaling ¹	10.82	CTNNB1 MYC
5	Gastric Cancer Network 2 ¹	10.47	CTNNB1 MYC
6	Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds ¹	9.88	CTNNB1 TNKS

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GO Terms for Lung Acinar Adenocarcinoma

Biological processes related to Lung Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.71	CTNNB1 MYC NKX2-1 TNKS
2	positive regulation of gene expression	GO:0010628	9.61	CTNNB1 MYC NKX2-1
3	branching involved in ureteric bud morphogenesis	GO:0001658	9.37	CTNNB1 MYC
4	beta-catenin-TCF complex assembly	GO:1904837	9.32	CTNNB1 MYC
5	positive regulation of telomere maintenance via telomerase	GO:0032212	9.26	CTNNB1 TNKS
6	positive regulation of mesenchymal cell proliferation	GO:0002053	9.16	CTNNB1 MYC
7	epithelial tube branching involved in lung morphogenesis	GO:0060441	8.96	CTNNB1 NKX2-1
8	positive regulation of telomerase activity	GO:0051973	8.8	CTNNB1 MYC TNKS

Molecular functions related to Lung Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	repressing transcription factor binding	GO:0070491	8.62	CTNNB1 MYC

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Sources for Lung Acinar Adenocarcinoma

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