MCID: LNG011
MIFTS: 35

Lung Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Adenoid Cystic Carcinoma

MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Lung 12 71
Pulmonary Adenoid Cystic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4872
NCIt 50 C5666
UMLS 71 C1334439

Summaries for Lung Adenoid Cystic Carcinoma

MalaCards based summary : Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to spindle cell sarcoma and mucoepidermoid carcinoma, and has symptoms including dyspnea, hemoptysis and chest pain. An important gene associated with Lung Adenoid Cystic Carcinoma is NFIB (Nuclear Factor I B), and among its related pathways/superpathways are IL4-mediated signaling events and Notch-mediated HES/HEY network. Affiliated tissues include lung, salivary gland and tongue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Lung Adenoid Cystic Carcinoma

Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 29.9 KRT7 KIT
2 mucoepidermoid carcinoma 29.7 MAML2 KRT7 CRTC1
3 small cell carcinoma 29.7 KRT7 KIT
4 adenoid cystic carcinoma 29.5 NFIB MYBL1 MYB KRT7 KIT
5 lacrimal gland adenocarcinoma 10.2 NFIB MYBL1
6 breast adenoid cystic carcinoma 10.2 NFIB MYBL1
7 lacrimal system cancer 10.2 NFIB MYBL1
8 synchronous bilateral breast carcinoma 10.2 NFIB KIT
9 lacrimal gland mucoepidermoid carcinoma 10.2 MAML2 CRTC1
10 schneiderian carcinoma 10.2 MAML2 CRTC1
11 breast mucoepidermoid carcinoma 10.2 MAML2 CRTC1
12 cervical adenosquamous carcinoma 10.2 MAML2 CRTC1
13 trachea adenoid cystic carcinoma 10.2 NFIB MYB
14 tracheal cancer 10.2 NFIB MYB
15 lipomatosis, multiple 10.2 NFIB KIT
16 pancreatic adenosquamous carcinoma 10.1 MAML2 CRTC1
17 sarcoma, synovial 10.1
18 sarcoma 10.1
19 soft tissue sarcoma 10.1
20 fibrosarcoma of bone 10.1 MYB KIT
21 bronchial disease 10.1
22 tracheal disease 10.1
23 lung cancer susceptibility 3 10.1
24 adenocarcinoma 10.1
25 gliosarcoma 10.1
26 pleomorphic adenoma carcinoma 10.0 NFIB MAML2 CRTC1
27 malignant acrospiroma 10.0 MAML2 KRT7
28 breast metaplastic carcinoma 10.0 MAML2 KRT7
29 eccrine sweat gland cancer 10.0 MAML2 KRT7
30 eccrine acrospiroma 10.0 MAML2 KRT7
31 ceruminous adenocarcinoma 10.0 KRT7 KIT
32 breast leiomyosarcoma 10.0 KRT7 KIT
33 eccrine sweat gland neoplasm 10.0 MAML2 KRT7
34 adenoid basal cell carcinoma 10.0 KRT7 KIT
35 polymorphous low-grade adenocarcinoma 10.0 NFIB MYB KIT
36 jejunal neoplasm 10.0 KRT7 KIT
37 intratubular embryonal carcinoma 10.0 KRT7 KIT
38 nasal cavity adenocarcinoma 10.0 NFIB KRT7
39 papillary cystadenocarcinoma 10.0 MAML2 KRT7
40 ceruminoma 10.0 MYBL1 KRT7
41 mucinous stomach adenocarcinoma 10.0 KRT7 KIT
42 keratinizing squamous cell carcinoma 10.0 MAML2 KRT7
43 sarcomatous intrahepatic cholangiocarcinoma 10.0 KRT7 KIT
44 eccrine adenocarcinoma 10.0 MYBL1 KRT7
45 liver leiomyosarcoma 9.9 KRT7 KIT
46 lung leiomyosarcoma 9.9 KRT7 KIT
47 bladder leiomyoma 9.9 KRT7 KIT
48 mediastinal cancer 9.9 KRT7 KIT
49 uterus leiomyosarcoma 9.9 KRT7 KIT
50 meckel diverticulum 9.9 KRT7 KIT

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:



Diseases related to Lung Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

UMLS symptoms related to Lung Adenoid Cystic Carcinoma:


dyspnea, hemoptysis, chest pain, pain, wheezing, coughing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 9.44 KIT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.44 DCHS2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.44 DCHS2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 9.44 DRG2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.44 KIT
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.44 DRG2 KIT
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 DCHS2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-188 9.44 DRG2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-2 9.44 DRG2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.44 DCHS2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.44 DRG2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.44 KIT

Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Adenoid Cystic Carcinoma

Genetic Tests for Lung Adenoid Cystic Carcinoma

Anatomical Context for Lung Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Lung Adenoid Cystic Carcinoma:

40
Lung, Salivary Gland, Tongue

Publications for Lung Adenoid Cystic Carcinoma

Articles related to Lung Adenoid Cystic Carcinoma:

(show all 12)
# Title Authors PMID Year
1
[Clinicopathological features of lung salivary gland-type tumors]. 61
31818065 2019
2
Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection. 61
31067606 2019
3
[The clinicopathological features and curative effect of the bronchoscopic interventional therapy combined with radiotherapy for the treatment of locally recurrent lung adenoid cystic carcinoma]. 61
30481940 2018
4
Primary mediastinal synovial sarcoma with subsequent development of primary adenoid cystic carcinoma of lung presenting as superior vena cava syndrome. 61
26992072 2018
5
[Four Cases Report on Primary Lung Adenoid Cystic Carcinoma]. 61
29167011 2017
6
Metachronous adenoid cystic carcinoma in the peripheral lung and at base of the tongue. 61
25177443 2014
7
A rare case of primary adenoid cystic carcinoma of lung. 61
25823114 2014
8
Primary adenoid cystic carcinoma of lung: a case report and review of the literature. 61
23771382 2013
9
[Recurrent adenoid cystic carcinoma. Review based on a case report]. 61
19145392 2009
10
Unusual lung mass: benign or malignant? 61
19035058 2008
11
Metastatic adenoid cystic carcinoma of lung: a case report. 61
17183870 2006
12
[Bilateral renal metastases of lung adenoid cystic carcinoma]. 61
1661561 1991

Variations for Lung Adenoid Cystic Carcinoma

Cosmic variations for Lung Adenoid Cystic Carcinoma:

9 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM102042323 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8009A>G p.? 16:72958974-72958974 6
2 COSM87291734 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
3 COSM102040476 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8037G>T p.? 16:72959002-72959002 6
4 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
5 COSM87290218 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
6 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
7 COSM126973051 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.770C>T p.P257L 11:102229729-102229729 6
8 COSM145028029 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1154C>T p.P385L 11:102229729-102229729 6
9 COSM128452039 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 6
10 COSM85237448 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1304C>T p.P435L 11:102229729-102229729 6
11 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 6
12 COSM127997731 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1256C>T p.P419L 11:102229729-102229729 6
13 COSM133274224 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1268C>T p.P423L 11:102229729-102229729 6
14 COSM90948266 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1202C>T p.P401L 11:102229729-102229729 6
15 COSM108017622 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 6
16 COSM95166535 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
17 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
18 COSM105839764 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 6
19 COSM106337415 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
20 COSM103711109 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1036A>C p.I346L 22:41653558-41653558 6
21 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 6
22 COSM134125623 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1114A>G p.M372V 19:43546970-43546970 6
23 COSM100781761 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.724A>T p.K242* 11:32392044-32392044 6
24 COSM111539040 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 6
25 COSM149728755 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
26 COSM130518653 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.673A>T p.K225* 11:32392044-32392044 6
27 COSM113475703 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
28 COSM111529696 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
29 COSM113484991 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
30 COSM147414475 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
31 COSM149739953 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
32 COSM148580942 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
33 COSM148593279 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
34 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
35 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
36 COSM147426277 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 6
37 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 6
38 COSM104050903 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 6
39 COSM105123686 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 6
40 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 6
41 COSM102763785 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 6
42 COSM99767946 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
43 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
44 COSM121848752 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
45 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
46 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 6
47 COSM99795256 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 6
48 COSM143996084 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1620C>G p.F540L 19:4947122-4947122 6
49 COSM143964403 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1428C>G p.F476L 19:4947122-4947122 6
50 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 6

Expression for Lung Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.

Pathways for Lung Adenoid Cystic Carcinoma

Pathways related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 MYBL1 MYB
2 10.64 MYB MAML2
3 10.62 NFIB MYBL1 MYB

GO Terms for Lung Adenoid Cystic Carcinoma

Biological processes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.02 NFIB MYBL1 MYB MAML2 CRTC1
2 positive regulation of Notch signaling pathway GO:0045747 8.96 MAML2 KIT

Sources for Lung Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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