MCID: LNG011
MIFTS: 32

Lung Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Adenoid Cystic Carcinoma

MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Lung 12 71
Pulmonary Adenoid Cystic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4872
NCIt 49 C5666
UMLS 71 C1334439

Summaries for Lung Adenoid Cystic Carcinoma

MalaCards based summary : Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to adenoid cystic carcinoma and small cell carcinoma, and has symptoms including dyspnea, chest pain and hemoptysis. An important gene associated with Lung Adenoid Cystic Carcinoma is ACCS (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive)). Affiliated tissues include lung, breast and salivary gland, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Lung Adenoid Cystic Carcinoma

Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 30.5 NFIB KIT ACCS
2 small cell carcinoma 10.2
3 lacrimal gland adenocarcinoma 10.2 NFIB ACCS
4 trachea adenoid cystic carcinoma 10.2 KIT ACCS
5 breast adenoid cystic carcinoma 10.1 NFIB ACCS
6 breast secretory carcinoma 10.1 NFIB MAML2
7 adenoid basal cell carcinoma 10.1 KIT ACCS
8 pleomorphic adenoma 10.1 MAML2 CRTC1
9 cervical adenoid cystic carcinoma 10.1 NFIB KIT
10 lacrimal gland mucoepidermoid carcinoma 10.1 MAML2 CRTC1
11 cutaneous mucoepidermoid carcinoma 10.1 MAML2 CRTC1
12 schneiderian carcinoma 10.1 MAML2 CRTC1
13 breast mucoepidermoid carcinoma 10.1 MAML2 CRTC1
14 retroperitoneal sarcoma 10.1 KIT ACCS
15 sarcoma, synovial 10.0
16 soft tissue sarcoma 10.0
17 bronchial disease 10.0
18 tracheal disease 10.0
19 back pain 10.0
20 lung cancer susceptibility 3 10.0
21 adenocarcinoma 10.0
22 gliosarcoma 10.0
23 mucoepidermoid carcinoma 10.0
24 47,xyy 10.0
25 bile duct mucoepidermoid carcinoma 10.0 MAML2 CRTC1
26 breast metaplastic carcinoma 10.0 MAML2 CRTC1
27 clear cell hidradenoma 10.0 MAML2 CRTC1
28 hidradenoma 10.0 MAML2 CRTC1
29 cribriform carcinoma 10.0 KIT ACCS
30 cervical adenosquamous carcinoma 10.0 MAML2 CRTC1
31 polymorphous low-grade adenocarcinoma 10.0 NFIB KIT
32 endobronchial lipoma 10.0 MAML2 CRTC1
33 acinar cell carcinoma 9.9 MAML2 ACCS
34 lacrimal system cancer 9.9 NFIB MAML2 ACCS
35 lacrimal gland carcinoma 9.9 NFIB MAML2 ACCS
36 pancreatic adenosquamous carcinoma 9.9 MAML2 CRTC1
37 sweat gland neoplasm 9.9 MAML2 CRTC1
38 cutaneous adenocystic carcinoma 9.9 NFIB KIT ACCS
39 pleomorphic adenoma carcinoma 9.8 NFIB MAML2 CRTC1
40 warthin tumor 9.8 MAML2 KIT CRTC1
41 lipomatosis, multiple 9.8 NFIB KIT
42 adenosquamous carcinoma 9.7 MAML2 KIT CRTC1
43 large cell carcinoma 9.5 KIT DDR2
44 tonsil cancer 9.2 NFIB MAML2 KIT CRTC1 ACCS
45 oropharynx cancer 9.2 NFIB MAML2 KIT CRTC1 ACCS
46 salivary gland disease 9.2 NFIB MAML2 KIT CRTC1 ACCS
47 salivary gland carcinoma 9.2 NFIB MAML2 KIT CRTC1 ACCS

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:



Diseases related to Lung Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

UMLS symptoms related to Lung Adenoid Cystic Carcinoma:


dyspnea, chest pain, hemoptysis, pain, wheezing, coughing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.5 DCHS2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.5 DRG2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.5 DCHS2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.5 KIT
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.5 DCHS2 DRG2 KIT
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.5 DCHS2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.5 DCHS2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.5 DRG2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.5 DCHS2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.5 DRG2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.5 KIT
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.5 DRG2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.5 DCHS2

Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Adenoid Cystic Carcinoma

Genetic Tests for Lung Adenoid Cystic Carcinoma

Anatomical Context for Lung Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Lung Adenoid Cystic Carcinoma:

40
Lung, Breast, Salivary Gland, Tongue, Tonsil, Trachea

Publications for Lung Adenoid Cystic Carcinoma

Articles related to Lung Adenoid Cystic Carcinoma:

(show all 12)
# Title Authors PMID Year
1
[Clinicopathological features of lung salivary gland-type tumors]. 61
31818065 2019
2
Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection. 61
31067606 2019
3
[The clinicopathological features and curative effect of the bronchoscopic interventional therapy combined with radiotherapy for the treatment of locally recurrent lung adenoid cystic carcinoma]. 61
30481940 2018
4
Primary mediastinal synovial sarcoma with subsequent development of primary adenoid cystic carcinoma of lung presenting as superior vena cava syndrome. 61
26992072 2018
5
[Four Cases Report on Primary Lung Adenoid Cystic Carcinoma]. 61
29167011 2017
6
Metachronous adenoid cystic carcinoma in the peripheral lung and at base of the tongue. 61
25177443 2014
7
A rare case of primary adenoid cystic carcinoma of lung. 61
25823114 2014
8
Primary adenoid cystic carcinoma of lung: a case report and review of the literature. 61
23771382 2013
9
[Recurrent adenoid cystic carcinoma. Review based on a case report]. 61
19145392 2009
10
Unusual lung mass: benign or malignant? 61
19035058 2008
11
Metastatic adenoid cystic carcinoma of lung: a case report. 61
17183870 2006
12
[Bilateral renal metastases of lung adenoid cystic carcinoma]. 61
1661561 1991

Variations for Lung Adenoid Cystic Carcinoma

Cosmic variations for Lung Adenoid Cystic Carcinoma:

9 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 9
2 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 9
3 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 9
4 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 9
5 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 9
6 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 9
7 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 9
8 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 9
9 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 9
10 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 9
11 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 9
12 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 9
13 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 9
14 COSM127070824 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 9
15 COSM127059821 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 9
16 COSM85195038 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 9
17 COSM130300868 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 9
18 COSM131090496 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 9
19 COSM131094722 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 9
20 COSM131094002 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 9
21 COSM87049256 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 9
22 COSM85721789 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 9
23 COSM90140992 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 9
24 COSM90145840 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 9
25 COSM87090089 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 9
26 COSM87898991 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 9
27 COSM87901497 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 9
28 COSM87935416 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 9
29 COSM87904420 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 9
30 COSM87898444 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 9
31 COSM87906107 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 9
32 COSM87909792 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 9
33 COSM87940740 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 9
34 COSM87899785 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 9
35 COSM87902162 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 9
36 COSM87915599 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 9
37 COSM87897914 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 9
38 COSM87899377 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 9
39 COSM87900565 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 9
40 COSM87918616 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 9
41 COSM87897711 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 9
42 COSM87900157 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 9
43 COSM87942817 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 9
44 COSM87903076 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 9
45 COSM87898836 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 9
46 COSM87898881 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 9
47 COSM150205149 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 9
48 COSM85378871 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 9
49 COSM90180942 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 9
50 COSM90180404 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 9

Expression for Lung Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.

Pathways for Lung Adenoid Cystic Carcinoma

GO Terms for Lung Adenoid Cystic Carcinoma

Biological processes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of Notch signaling pathway GO:0045747 8.62 MAML2 KIT

Molecular functions related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 KIT DDR2

Sources for Lung Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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