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MCID: LNG011
MIFTS: 43

Lung Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Lung Adenoid Cystic Carcinoma

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MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Lung 12 74
Pulmonary Adenoid Cystic Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4872
NCIt 51 C5666
UMLS 74 C1334439
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Summaries for Lung Adenoid Cystic Carcinoma

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MalaCards based summary : Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to sarcoma and small cell carcinoma, and has symptoms including dyspnea, hemoptysis and pain. An important gene associated with Lung Adenoid Cystic Carcinoma is DDR2 (Discoidin Domain Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include lung, breast and prostate, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Lung Adenoid Cystic Carcinoma

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Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 sarcoma 29.6 HRAS KIT KRAS PIK3CA
2 small cell carcinoma 29.4 EGFR KIT KRT7 NKX2-1 PDGFRA
3 adenoid cystic carcinoma 29.0 HRAS KIT KRAS KRT7 NFIB PIK3CA
4 rete testis neoplasm 10.4 KIT NKX2-1
5 chronic eosinophilic leukemia 10.4 KIT PDGFRA
6 heart sarcoma 10.4 KIT PDGFRA
7 perineurioma 10.4 ALK KIT
8 reticular perineurioma 10.3 KIT PDGFRA
9 rosai-dorfman disease 10.3 KRAS PDGFRA
10 sm-ahnmd 10.3 KIT PDGFRA
11 malignant spindle cell melanoma 10.3 KIT SOX10
12 gastric leiomyosarcoma 10.3 KIT PDGFRA
13 conventional fibrosarcoma 10.3 KIT PDGFRA
14 endometrial small cell carcinoma 10.3 KIT PDGFRA
15 desmoid tumor 10.3 KIT PDGFRA
16 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.3 KRAS PIK3CA
17 hypereosinophilic syndrome, idiopathic 10.3 KIT PDGFRA
18 rete testis adenocarcinoma 10.3 KIT NKX2-1
19 breast angiosarcoma 10.3 KIT SOX10
20 pulmonary vein stenosis 10.3 KIT PDGFRA
21 prostate small cell carcinoma 10.2 KIT NKX2-1
22 solid adenocarcinoma with mucin production 10.2 KRT7 NKX2-1
23 ovarian germ cell teratoma 10.2 KRT7 NKX2-1
24 ceruminoma 10.2 KIT KRT7
25 hidrocystoma 10.2 KRT7 SOX10
26 lung acinar adenocarcinoma 10.2 KRT7 NKX2-1
27 jejunal cancer 10.2 KIT KRT7
28 small cell carcinoma of the bladder 10.2 KRT7 NKX2-1
29 ovarian germ cell cancer 10.2 KRT7 NKX2-1
30 rare adenocarcinoma of the breast 10.2 KRAS PIK3CA
31 apocrine sweat gland neoplasm 10.2 KRT7 SOX10
32 intratubular embryonal carcinoma 10.2 KIT KRT7
33 breast myoepithelial neoplasm 10.2 KRT7 PIK3CA
34 papillary adenoma 10.2 KRT7 NKX2-1
35 cribriform carcinoma 10.2 KIT KRT7
36 chromosome 14q11-q22 deletion syndrome 10.2 HRAS NKX2-1
37 neurilemmoma 10.2 KIT PDGFRA SOX10
38 neurofibroma 10.2 KIT PDGFRA SOX10
39 adenoid basal cell carcinoma 10.2 KIT KRT7
40 thymoma, familial 10.2 HRAS KIT
41 malignant leydig cell tumor 10.2 KIT KRT7
42 papillary serous adenocarcinoma 10.2 KRT7 NKX2-1
43 ovarian cystadenocarcinoma 10.2 HRAS KRAS
44 colloid carcinoma of the pancreas 10.2 HRAS KRAS
45 malignant conjunctival melanoma 10.2 HRAS SOX10
46 respiratory system benign neoplasm 10.2 KRAS NKX2-1
47 breast adenoid cystic carcinoma 10.2 KIT NFIB
48 breast adenomyoepithelioma 10.2 KRT7 PIK3CA
49 ovarian melanoma 10.2 HRAS KIT
50 duodenum adenocarcinoma 10.2 KRAS KRT7

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:



Diseases related to Lung Adenoid Cystic Carcinoma
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Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

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UMLS symptoms related to Lung Adenoid Cystic Carcinoma:


dyspnea, hemoptysis, pain, chest pain, wheezing, coughing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

27 (show all 44)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 11.02 HRAS KRAS PIK3CA EGFR
2 Decreased viability GR00106-A-0 11.02 KRAS
3 Decreased viability GR00173-A 11.02 PDGFRA
4 Decreased viability GR00221-A-1 11.02 DDR2 HRAS KRAS PIK3CA ALK EGFR
5 Decreased viability GR00221-A-2 11.02 DDR2 HRAS KRAS PIK3CA
6 Decreased viability GR00221-A-3 11.02 HRAS PDGFRA
7 Decreased viability GR00221-A-4 11.02 DDR2 PIK3CA ALK EGFR PDGFRA
8 Decreased viability GR00301-A 11.02 KRAS KIT
9 Decreased viability GR00381-A-1 11.02 KRAS
10 Decreased viability GR00402-S-2 11.02 DDR2 HRAS KRAS PIK3CA ALK EGFR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.17 SOX10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.17 KRAS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.17 SOX10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.17 PIK3CA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.17 KRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-129 10.17 PDGFRA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.17 PDGFRA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.17 PIK3CA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.17 PIK3CA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.17 PIK3CA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.17 KRAS
22 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.17 KRAS PIK3CA SOX10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.17 PIK3CA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.17 KRAS
25 Increased shRNA abundance (Z-score > 2) GR00366-A-207 10.17 PDGFRA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.17 KRAS
27 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.17 PDGFRA SOX10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.17 PIK3CA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.17 KRAS PDGFRA PIK3CA SOX10
30 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.17 KRAS
31 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.17 KRAS
32 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.17 SOX10
33 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.17 SOX10
34 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.17 PDGFRA
35 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.17 SOX10
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.17 SOX10
37 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.17 KRAS
38 Decreased viability in esophageal squamous lineage GR00235-A 9.96 DDR2 HRAS KIT KRAS KRT7 NFIB
39 Decreased cell migration GR00055-A-1 9.88 ALK DDR2 EGFR HRAS KRAS PIK3CA
40 Decreased substrate adherent cell growth GR00193-A-1 9.77 KIT
41 Decreased substrate adherent cell growth GR00193-A-2 9.77 ALK EGFR KIT
42 Decreased substrate adherent cell growth GR00193-A-4 9.77 KIT
43 Increased cell migration GR00055-A-3 9.55 DDR2 EGFR HRAS KRAS PIK3CA
44 Increased transferrin (TF) endocytosis GR00363-A 9.28 ALK DDR2 EGFR HRAS KIT NKX2-1

MGI Mouse Phenotypes related to Lung Adenoid Cystic Carcinoma:

47 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ALK DDR2 EGFR HRAS KIT KRAS
2 endocrine/exocrine gland MP:0005379 10.31 ALK DDR2 EGFR HRAS KIT KRAS
3 growth/size/body region MP:0005378 10.3 ALK DDR2 EGFR HRAS KIT KRAS
4 mortality/aging MP:0010768 10.25 ALK DDR2 EGFR HRAS KIT KRAS
5 cellular MP:0005384 10.24 DDR2 EGFR KIT KRAS KRT7 NKX2-1
6 behavior/neurological MP:0005386 10.21 ALK HRAS KIT KRAS NKX2-1 PDGFRA
7 cardiovascular system MP:0005385 10.2 DDR2 EGFR HRAS KIT KRAS NKX2-1
8 nervous system MP:0003631 10.2 ALK DDR2 EGFR HRAS KIT KRAS
9 integument MP:0010771 10.19 ALK DDR2 EGFR HRAS KIT KRAS
10 digestive/alimentary MP:0005381 10.18 EGFR HRAS KIT KRAS NFIB NKX2-1
11 neoplasm MP:0002006 10.18 ALK DDR2 EGFR HRAS KIT KRAS
12 craniofacial MP:0005382 10.13 DDR2 EGFR HRAS KIT KRAS NFIB
13 no phenotypic analysis MP:0003012 10.09 DDR2 EGFR HRAS KIT KRAS NKX2-1
14 limbs/digits/tail MP:0005371 10 DDR2 EGFR KIT KRAS PDGFRA SOX10
15 muscle MP:0005369 9.97 DDR2 EGFR KIT KRAS PDGFRA PIK3CA
16 normal MP:0002873 9.95 EGFR HRAS KIT KRAS NKX2-1 PDGFRA
17 reproductive system MP:0005389 9.86 ALK DDR2 EGFR KIT KRAS NKX2-1
18 pigmentation MP:0001186 9.85 ALK EGFR KIT KRAS PDGFRA SOX10
19 respiratory system MP:0005388 9.81 ALK EGFR HRAS KIT KRAS NFIB
20 renal/urinary system MP:0005367 9.8 EGFR HRAS KIT KRAS KRT7 PDGFRA
21 skeleton MP:0005390 9.61 ALK DDR2 EGFR HRAS KIT KRAS
22 vision/eye MP:0005391 9.17 ALK DDR2 EGFR KIT KRAS NFIB
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Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

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Search Clinical Trials , NIH Clinical Center for Lung Adenoid Cystic Carcinoma

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Genetic Tests for Lung Adenoid Cystic Carcinoma

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Anatomical Context for Lung Adenoid Cystic Carcinoma

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MalaCards organs/tissues related to Lung Adenoid Cystic Carcinoma:

42
Lung, Breast, Prostate, Thyroid, Ovary, Pancreas, Testis
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Publications for Lung Adenoid Cystic Carcinoma

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Articles related to Lung Adenoid Cystic Carcinoma:

# Title Authors Year
1
Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection. ( 31067606 )
2019
2
Primary mediastinal synovial sarcoma with subsequent development of primary adenoid cystic carcinoma of lung presenting as superior vena cava syndrome. ( 26992072 )
2018
3
A rare case of primary adenoid cystic carcinoma of lung. ( 25823114 )
2014
4
Primary adenoid cystic carcinoma of lung: a case report and review of the literature. ( 23771382 )
2013
5
Metastatic adenoid cystic carcinoma of lung: a case report. ( 17183870 )
2006
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Variations for Lung Adenoid Cystic Carcinoma

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Cosmic variations for Lung Adenoid Cystic Carcinoma:

9 (show top 50) (show all 548)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 0
2 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 0
3 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 0
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 0
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 0
6 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 0
7 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 0
8 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 0
9 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 0
10 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 0
11 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 0
12 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 0
13 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 0
14 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 0
15 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 0
16 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 0
17 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 0
18 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 0
19 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 0
20 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 0
21 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 0
22 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 0
23 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 0
24 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 0
25 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 0
26 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 0
27 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 0
28 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 0
29 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 0
30 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 0
31 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 0
32 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 0
33 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 0
34 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 0
35 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 0
36 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 0
37 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 0
38 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 0
39 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 0
40 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 0
41 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 0
42 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 0
43 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 0
44 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 0
45 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 0
46 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 0
47 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 0
48 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 0
49 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 0
50 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 0
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Expression for Lung Adenoid Cystic Carcinoma

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Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.
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Pathways for Lung Adenoid Cystic Carcinoma

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Pathways related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 65
Show member pathways
 13.8 ALK DDR2 EGFR HRAS KIT KRAS
2
GPCR Pathway 65
Show member pathways
 13.67 ALK DDR2 EGFR HRAS KIT KRAS
3
PEDF Induced Signaling 65
Show member pathways
 13.63 ALK DDR2 EGFR HRAS KIT KRAS
4
Activation of cAMP-Dependent PKA 65
Show member pathways
 13.51 ALK DDR2 EGFR HRAS KIT KRAS
5
TGF-Beta Pathway 65
Show member pathways
 13.47 ALK DDR2 EGFR HRAS KIT KRAS
6
Developmental Biology 67
Show member pathways
 13.46 EGFR HRAS KIT KRAS KRT7 PDGFRA
7
Class I MHC mediated antigen processing and presentation 67
Show member pathways
 13.41 EGFR HRAS KIT KRAS PDGFRA PIK3CA
8
Akt Signaling 65
Show member pathways
 13.37 ALK DDR2 EGFR HRAS KIT KRAS
9
Cytokine Signaling in Immune system 67
Show member pathways
 13.32 EGFR HRAS KIT KRAS PDGFRA PIK3CA
10
CREB Pathway 65
Show member pathways
 13.28 ALK DDR2 EGFR HRAS KIT KRAS
11
Nanog in Mammalian ESC Pluripotency 65
Show member pathways
 13.22 ALK DDR2 EGFR HRAS KIT KRAS
12
Phospholipase-C Pathway 65
Show member pathways
 13.03 EGFR HRAS KIT KRAS PDGFRA
13
Actin Nucleation by ARP-WASP Complex 65
Show member pathways
 12.98 ALK DDR2 EGFR HRAS KIT PDGFRA
14
PI3K-Akt signaling pathway 38
Show member pathways
 12.96 EGFR HRAS KIT KRAS PDGFRA PIK3CA
15
Human cytomegalovirus infection 38
Show member pathways
 12.93 EGFR HRAS KRAS PDGFRA PIK3CA
16
Development Angiotensin activation of ERK 23
Show member pathways
 12.92 EGFR HRAS KIT KRAS PDGFRA PIK3CA
17
Focal Adhesion 1 38
Show member pathways
 12.88 EGFR HRAS KRAS PDGFRA PIK3CA
18
p70S6K Signaling 65
Show member pathways
 12.86 ALK DDR2 EGFR HRAS KIT KRAS
19
NFAT and Cardiac Hypertrophy 65
Show member pathways
 12.84 EGFR HRAS KRAS PDGFRA PIK3CA
20
Endometrial cancer 38
Show member pathways
 12.81 EGFR HRAS KIT KRAS PDGFRA PIK3CA
21
MAPK signaling pathway 1 38
12.75 EGFR HRAS KIT KRAS PDGFRA
22
Gastric cancer 38
Show member pathways
 12.75 EGFR HRAS KIT KRAS PIK3CA
23
4-1BB Pathway 65
Show member pathways
 12.66 EGFR HRAS KRAS PDGFRA
24
Development Endothelin-1/EDNRA signaling 23
Show member pathways
 12.65 EGFR HRAS KRAS PIK3CA
25
Regulation of actin cytoskeleton 38 1
12.64 EGFR HRAS KRAS PDGFRA PIK3CA
26
Ras signaling pathway 38
Show member pathways
 12.61 EGFR HRAS KIT KRAS PDGFRA PIK3CA
27
Downstream signaling events of B Cell Receptor (BCR) 67
Show member pathways
 12.59 EGFR HRAS KIT KRAS PDGFRA PIK3CA
28
ErbB signaling pathway 1 38
Show member pathways
 12.58 EGFR HRAS KRAS PIK3CA
29
Immune response IL-23 signaling pathway 23
Show member pathways
 12.58 EGFR HRAS KRAS PDGFRA PIK3CA
30
Glioma 38
Show member pathways
 12.58 ALK EGFR HRAS KRAS PDGFRA PIK3CA
31
Pathways in cancer 38
12.53 ALK EGFR HRAS KIT KRAS PDGFRA
32
Development EGFR signaling pathway 23
Show member pathways
 12.52 EGFR HRAS KRAS PIK3CA
33
MicroRNAs in cancer 38
12.48 EGFR HRAS KRAS PDGFRA PIK3CA
34
mTOR signaling pathway (KEGG) 38
Show member pathways
 12.45 EGFR HRAS KRAS PDGFRA PIK3CA
35
VEGF Pathway (Qiagen) 65
Show member pathways
 12.4 EGFR HRAS KRAS PIK3CA
36
Apoptosis Pathway 73
Show member pathways
 12.37 EGFR HRAS KRAS PDGFRA PIK3CA
37
Human T-cell leukemia virus 1 infection 38
12.36 HRAS KRAS PDGFRA PIK3CA
38
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.36 EGFR HRAS KRAS PDGFRA PIK3CA
39
Development Ligand-independent activation of ESR1 and ESR2 23
Show member pathways
 12.32 EGFR HRAS PDGFRA PIK3CA
40
Signaling by ERBB2 67
Show member pathways
 12.32 EGFR HRAS KRAS PIK3CA
41
Proteoglycans in cancer 38
12.3 EGFR HRAS KRAS PIK3CA
42
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.25 EGFR KIT KRAS PDGFRA
43
Axon guidance 38
12.22 HRAS KRAS PIK3CA
44
Cell surface interactions at the vascular wall 67
Show member pathways
 12.21 HRAS KRAS PIK3CA
45
VEGF Signaling Pathway 68 62
Show member pathways
 12.21 EGFR HRAS KRAS
46
C-type lectin receptor signaling pathway 38
Show member pathways
 12.2 HRAS KRAS PIK3CA
47
GDNF-Family Ligands and Receptor Interactions 65
Show member pathways
 12.18 HRAS KRAS PIK3CA
48
EGF/EGFR Signaling Pathway 1
12.17 EGFR HRAS KRAS
49
Kit receptor signaling pathway 1
Show member pathways
 12.16 HRAS KIT PIK3CA
50
Cellular senescence (KEGG) 38
12.15 HRAS KRAS PIK3CA
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GO Terms for Lung Adenoid Cystic Carcinoma

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Cellular components related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.56 EGFR HRAS KIT KRAS KRT7 PDGFRA
2 receptor complex GO:0043235 9.02 ALK DDR2 EGFR KIT PDGFRA

Biological processes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.99 ALK DDR2 EGFR KIT PDGFRA PIK3CA
2 positive regulation of gene expression GO:0010628 9.96 HRAS KIT KRAS NKX2-1 SOX10
3 positive regulation of cell migration GO:0030335 9.91 EGFR HRAS KIT PDGFRA
4 positive regulation of cell proliferation GO:0008284 9.91 DDR2 EGFR HRAS KIT KRAS PDGFRA
5 positive regulation of protein kinase B signaling GO:0051897 9.85 EGFR KIT PDGFRA PIK3CA
6 regulation of cell proliferation GO:0042127 9.84 ALK EGFR KIT
7 negative regulation of neuron apoptotic process GO:0043524 9.83 HRAS KRAS PIK3CA
8 animal organ morphogenesis GO:0009887 9.81 HRAS NKX2-1 PDGFRA
9 MAPK cascade GO:0000165 9.8 EGFR HRAS KIT KRAS PDGFRA
10 liver development GO:0001889 9.79 EGFR KRAS PIK3CA
11 cell differentiation GO:0030154 9.77 DDR2 EGFR SOX10
12 positive regulation of fibroblast proliferation GO:0048146 9.76 DDR2 EGFR PDGFRA
13 lung development GO:0030324 9.76 EGFR NFIB NKX2-1 PDGFRA
14 positive regulation of protein phosphorylation GO:0001934 9.74 EGFR HRAS KRAS
15 positive regulation of MAPK cascade GO:0043410 9.71 HRAS KIT PDGFRA
16 regulation of long-term neuronal synaptic plasticity GO:0048169 9.66 HRAS KRAS
17 melanocyte differentiation GO:0030318 9.65 KIT SOX10
18 epithelial tube branching involved in lung morphogenesis GO:0060441 9.65 KRAS NKX2-1
19 peptidyl-tyrosine phosphorylation GO:0018108 9.65 ALK DDR2 EGFR KIT PDGFRA
20 digestive tract morphogenesis GO:0048546 9.64 EGFR SOX10
21 tongue development GO:0043586 9.63 EGFR KIT
22 cerebral cortex cell migration GO:0021795 9.63 EGFR NKX2-1
23 Leydig cell differentiation GO:0033327 9.62 NKX2-1 PDGFRA
24 positive regulation of MAP kinase activity GO:0043406 9.62 EGFR HRAS KIT KRAS
25 response to isolation stress GO:0035900 9.61 HRAS KRAS
26 type II pneumocyte differentiation GO:0060510 9.6 NFIB NKX2-1
27 Clara cell differentiation GO:0060486 9.58 NFIB NKX2-1
28 protein autophosphorylation GO:0046777 9.55 ALK DDR2 EGFR KIT PDGFRA
29 positive regulation of phospholipase C activity GO:0010863 9.54 HRAS KIT PDGFRA
30 negative regulation of apoptotic process GO:0043066 9.48 EGFR SOX10
31 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.26 EGFR HRAS KIT PDGFRA
32 phosphatidylinositol phosphorylation GO:0046854 9.19 PIK3CA
33 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.02 ALK DDR2 EGFR KIT PDGFRA
34 phosphorylation GO:0016310 10 ALK DDR2 EGFR KIT PDGFRA PIK3CA

Molecular functions related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.91 ALK DDR2 EGFR KIT PDGFRA PIK3CA
2 protein kinase activity GO:0004672 9.8 ALK DDR2 EGFR KIT PDGFRA
3 kinase activity GO:0016301 9.8 ALK DDR2 EGFR KIT PDGFRA PIK3CA
4 nucleotide binding GO:0000166 9.77 EGFR HRAS KIT KRAS PDGFRA
5 protein tyrosine kinase activity GO:0004713 9.35 ALK DDR2 EGFR KIT PDGFRA
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 ALK DDR2 EGFR KIT PDGFRA
7 transmembrane signaling receptor activity GO:0004888 8.96 EGFR
8 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.85 PIK3CA
Sources

Sources for Lung Adenoid Cystic Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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