MCID: LNG011
MIFTS: 33

Lung Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Adenoid Cystic Carcinoma

MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Lung 12 71
Pulmonary Adenoid Cystic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4872
NCIt 49 C5666
UMLS 71 C1334439

Summaries for Lung Adenoid Cystic Carcinoma

MalaCards based summary : Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to mucoepidermoid carcinoma and adenoid cystic carcinoma, and has symptoms including dyspnea, chest pain and hemoptysis. An important gene associated with Lung Adenoid Cystic Carcinoma is ACCS (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive)), and among its related pathways/superpathways is Pathways Affected in Adenoid Cystic Carcinoma. Affiliated tissues include lung, salivary gland and tongue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Lung Adenoid Cystic Carcinoma

Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 mucoepidermoid carcinoma 29.7 MAML2 KRT7 CRTC1
2 adenoid cystic carcinoma 29.6 NFIB MYBL1 KRT7 KIT ACCS
3 small cell carcinoma 29.6 KRT7 KIT
4 lacrimal gland adenocarcinoma 10.3 NFIB ACCS
5 retroperitoneal sarcoma 10.2 KIT ACCS
6 polymorphous low-grade adenocarcinoma 10.2 NFIB KIT
7 lacrimal gland mucoepidermoid carcinoma 10.2 MAML2 CRTC1
8 schneiderian carcinoma 10.2 MAML2 CRTC1
9 malignant acrospiroma 10.2 MAML2 KRT7
10 breast mucoepidermoid carcinoma 10.2 MAML2 CRTC1
11 necrotizing sialometaplasia 10.1 MAML2 KRT7
12 eccrine acrospiroma 10.1 MAML2 KRT7
13 apocrine sweat gland neoplasm 10.1 NFIB KRT7
14 eccrine sweat gland neoplasm 10.1 MAML2 KRT7
15 eccrine porocarcinoma 10.1 MAML2 KRT7
16 cervical adenosquamous carcinoma 10.1 MAML2 CRTC1
17 anus basaloid carcinoma 10.1 KRT7 KIT
18 anal canal carcinoma 10.1 KRT7 ACCS
19 ceruminous adenocarcinoma 10.1 KRT7 KIT
20 jejunal neoplasm 10.1 KRT7 KIT
21 papillary cystadenocarcinoma 10.1 MAML2 KRT7
22 intratubular embryonal carcinoma 10.1 KRT7 KIT
23 keratinizing squamous cell carcinoma 10.1 MAML2 KRT7
24 liver leiomyosarcoma 10.1 KRT7 KIT
25 lipomatosis, multiple 10.1 NFIB KIT
26 breast leiomyosarcoma 10.1 KRT7 KIT
27 thymus clear cell carcinoma 10.1 KRT7 KIT
28 sarcomatous intrahepatic cholangiocarcinoma 10.1 KRT7 KIT
29 mucinous stomach adenocarcinoma 10.1 KRT7 KIT
30 acinar cell carcinoma 10.1 KRT7 ACCS
31 pancreatic adenosquamous carcinoma 10.1 MAML2 CRTC1
32 ceruminoma 10.1 MYBL1 KRT7
33 mediastinal cancer 10.1 KRT7 KIT
34 epithelial-myoepithelial carcinoma 10.1 MAML2 KRT7
35 uterus leiomyosarcoma 10.1 KRT7 KIT
36 ovarian germ cell cancer 10.1 KRT7 KIT
37 heart cancer 10.1 KRT7 KIT
38 vulvar disease 10.1 KRT7 KIT
39 sweat gland disease 10.1 MAML2 KRT7
40 retroperitoneum carcinoma 10.1 KRT7 KIT
41 kidney benign neoplasm 10.1 KRT7 KIT
42 mature teratoma 10.1 KRT7 KIT
43 pleomorphic carcinoma 10.0 KRT7 KIT
44 sarcoma, synovial 10.0
45 soft tissue sarcoma 10.0
46 bronchial disease 10.0
47 tracheal disease 10.0
48 back pain 10.0
49 lung cancer susceptibility 3 10.0
50 adenocarcinoma 10.0

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:



Diseases related to Lung Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

UMLS symptoms related to Lung Adenoid Cystic Carcinoma:


dyspnea, chest pain, hemoptysis, pain, wheezing, coughing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 9.44 KIT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.44 DCHS2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.44 DCHS2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 9.44 DRG2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.44 KIT
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.44 DRG2 KIT
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 DCHS2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-188 9.44 DRG2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-2 9.44 DRG2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.44 DCHS2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.44 DRG2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.44 KIT

Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Adenoid Cystic Carcinoma

Genetic Tests for Lung Adenoid Cystic Carcinoma

Anatomical Context for Lung Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Lung Adenoid Cystic Carcinoma:

40
Lung, Salivary Gland, Tongue

Publications for Lung Adenoid Cystic Carcinoma

Articles related to Lung Adenoid Cystic Carcinoma:

(show all 12)
# Title Authors PMID Year
1
[Clinicopathological features of lung salivary gland-type tumors]. 61
31818065 2019
2
Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection. 61
31067606 2019
3
[The clinicopathological features and curative effect of the bronchoscopic interventional therapy combined with radiotherapy for the treatment of locally recurrent lung adenoid cystic carcinoma]. 61
30481940 2018
4
Primary mediastinal synovial sarcoma with subsequent development of primary adenoid cystic carcinoma of lung presenting as superior vena cava syndrome. 61
26992072 2018
5
[Four Cases Report on Primary Lung Adenoid Cystic Carcinoma]. 61
29167011 2017
6
Metachronous adenoid cystic carcinoma in the peripheral lung and at base of the tongue. 61
25177443 2014
7
A rare case of primary adenoid cystic carcinoma of lung. 61
25823114 2014
8
Primary adenoid cystic carcinoma of lung: a case report and review of the literature. 61
23771382 2013
9
[Recurrent adenoid cystic carcinoma. Review based on a case report]. 61
19145392 2009
10
Unusual lung mass: benign or malignant? 61
19035058 2008
11
Metastatic adenoid cystic carcinoma of lung: a case report. 61
17183870 2006
12
[Bilateral renal metastases of lung adenoid cystic carcinoma]. 61
1661561 1991

Variations for Lung Adenoid Cystic Carcinoma

Cosmic variations for Lung Adenoid Cystic Carcinoma:

9 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 9
2 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 9
3 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 9
4 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 9
5 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 9
6 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 9
7 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 9
8 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 9
9 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 9
10 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 9
11 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 9
12 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 9
13 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 9
14 COSM127070824 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 9
15 COSM127059821 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 9
16 COSM85195038 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 9
17 COSM130300868 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 9
18 COSM131090496 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 9
19 COSM131094722 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 9
20 COSM131094002 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 9
21 COSM87049256 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 9
22 COSM85721789 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 9
23 COSM90140992 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 9
24 COSM90145840 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 9
25 COSM87090089 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 9
26 COSM87898991 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 9
27 COSM87901497 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 9
28 COSM87935416 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 9
29 COSM87904420 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 9
30 COSM87898444 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 9
31 COSM87906107 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 9
32 COSM87909792 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 9
33 COSM87940740 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 9
34 COSM87899785 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 9
35 COSM87902162 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 9
36 COSM87915599 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 9
37 COSM87897914 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 9
38 COSM87899377 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 9
39 COSM87900565 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 9
40 COSM87918616 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 9
41 COSM87897711 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 9
42 COSM87900157 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 9
43 COSM87942817 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 9
44 COSM87903076 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 9
45 COSM87898836 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 9
46 COSM87898881 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 9
47 COSM150205149 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 9
48 COSM85378871 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 9
49 COSM90180942 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 9
50 COSM90180404 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 9

Expression for Lung Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.

Pathways for Lung Adenoid Cystic Carcinoma

Pathways related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 NFIB MYBL1

GO Terms for Lung Adenoid Cystic Carcinoma

Biological processes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of Notch signaling pathway GO:0045747 8.62 MAML2 KIT

Sources for Lung Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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