MCID: LNG011
MIFTS: 40

Lung Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Adenoid Cystic Carcinoma

MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Lung 12 73
Pulmonary Adenoid Cystic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4872
NCIt 50 C5666
UMLS 73 C1334439

Summaries for Lung Adenoid Cystic Carcinoma

MalaCards based summary : Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to sarcoma and adenoid cystic carcinoma, and has symptoms including chest pain, coughing and dyspnea. An important gene associated with Lung Adenoid Cystic Carcinoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are GPCR Pathway and HIV Life Cycle. Affiliated tissues include lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Lung Adenoid Cystic Carcinoma

Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 sarcoma 28.8 HRAS KIT KRAS PIK3CA
2 adenoid cystic carcinoma 27.9 FBXW7 HRAS KIT KRAS NFIB PIK3CA
3 squamous cell carcinoma 27.6 DDR2 EGFR HRAS KRAS PIK3CA
4 rare adenocarcinoma of the breast 10.6 KRAS PIK3CA
5 reticular perineurioma 10.5 KIT PDGFRA
6 sm-ahnmd 10.5 KIT PDGFRA
7 gastric leiomyosarcoma 10.5 KIT PDGFRA
8 desmoid tumor 10.5 KIT PDGFRA
9 sarcomatoid renal cell carcinoma 10.5 KIT PDGFRA
10 conventional fibrosarcoma 10.5 KIT PDGFRA
11 rete testis adenocarcinoma 10.5 KIT NKX2-1
12 clear cell adenofibroma 10.5 PDGFRA PIK3CA
13 endometrial small cell carcinoma 10.4 KIT PDGFRA
14 pulmonary vein stenosis 10.4 KIT PDGFRA
15 hypereosinophilic syndrome, idiopathic 10.4 KIT PDGFRA
16 prostate adenoid cystic carcinoma 10.4 HRAS PIK3CA
17 kyasanur forest disease 10.4 ALK KRAS
18 papillary hidradenoma 10.4 KIT PIK3CA
19 lung papillary adenocarcinoma 10.4 ALK EML4
20 chromosome 14q11-q22 deletion syndrome 10.4 HRAS NKX2-1
21 respiratory system benign neoplasm 10.4 KRAS NKX2-1
22 bladder adenocarcinoma 10.3 FBXW7 HRAS
23 carney triad 10.3 KIT PDGFRA
24 malignant struma ovarii 10.3 HRAS NKX2-1
25 heart sarcoma 10.3 KIT PDGFRA
26 thymoma, familial 10.2 HRAS KIT
27 ovarian melanoma 10.2 HRAS KIT
28 chronic eosinophilic leukemia 10.2 KIT PDGFRA
29 sigmoid neoplasm 10.2 HRAS KRAS
30 mesenchymal cell neoplasm 10.1 ALK KIT PDGFRA
31 serous cystadenocarcinoma 10.1 FBXW7 HRAS PIK3CA
32 rosai-dorfman disease 10.1 KRAS PDGFRA
33 cystadenocarcinoma 10.1 FBXW7 HRAS PIK3CA
34 schimmelpenning-feuerstein-mims syndrome 10.1 HRAS KRAS
35 periampullary adenoma 10.1 HRAS KRAS
36 ovarian serous cystadenocarcinoma 10.1 FBXW7 HRAS PIK3CA
37 rete testis neoplasm 10.1 KIT NKX2-1
38 bile duct cysts 10.1 HRAS KRAS
39 breast squamous cell carcinoma 10.1 EGFR PIK3CA
40 secondary hypertrophic osteoarthropathy 10.1 HRAS KRAS
41 adenoiditis 10.0
42 nasal cavity adenocarcinoma 10.0 HRAS KRAS
43 thyroid cancer, nonmedullary, 2 10.0 HRAS NKX2-1 PIK3CA
44 anal canal adenocarcinoma 10.0 HRAS KRAS
45 ovary serous adenocarcinoma 10.0 HRAS KRAS
46 cervical adenosquamous carcinoma 10.0 EGFR PDGFRA
47 ampulla of vater neoplasm 9.9 HRAS KRAS
48 ovarian cystadenocarcinoma 9.9 HRAS KRAS
49 sarcoma, synovial 9.9
50 mediastinitis 9.9

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:



Diseases related to Lung Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

UMLS symptoms related to Lung Adenoid Cystic Carcinoma:


chest pain, coughing, dyspnea, hemoptysis, pain, wheezing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 37)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 11.02 HRAS EGFR KRAS PIK3CA
2 Decreased viability GR00106-A-0 11.02 KRAS
3 Decreased viability GR00173-A 11.02 PDGFRA
4 Decreased viability GR00221-A-1 11.02 DDR2 HRAS EGFR ALK KIT KRAS
5 Decreased viability GR00221-A-2 11.02 DDR2 HRAS KRAS PIK3CA
6 Decreased viability GR00221-A-3 11.02 HRAS PDGFRA
7 Decreased viability GR00221-A-4 11.02 DDR2 EGFR ALK PIK3CA PDGFRA
8 Decreased viability GR00301-A 11.02 KRAS KIT
9 Decreased viability GR00381-A-1 11.02 KRAS
10 Decreased viability GR00402-S-2 11.02 DDR2 HRAS EGFR ALK KIT KRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.05 KIT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.05 PIK3CA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.05 FBXW7
14 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.05 FBXW7
15 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.05 FBXW7 KIT
16 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.05 FBXW7 KIT PIK3CA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.05 PIK3CA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.05 PIK3CA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.05 KIT
20 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.05 FBXW7 PIK3CA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.05 FBXW7
22 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.05 PIK3CA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.05 KIT
24 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.05 KIT PIK3CA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.05 FBXW7
26 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.05 PIK3CA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.05 FBXW7
28 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.05 KIT
29 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.05 KIT
30 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.05 KIT
31 Decreased cell migration GR00055-A-1 9.88 HRAS EGFR ALK DDR2 KRAS PIK3CA
32 Decreased viability in esophageal squamous lineage GR00235-A 9.86 DDR2 KIT KRAS NFIB NKX2-1 HRAS
33 Decreased substrate adherent cell growth GR00193-A-1 9.77 KIT
34 Decreased substrate adherent cell growth GR00193-A-2 9.77 ALK EGFR KIT
35 Decreased substrate adherent cell growth GR00193-A-4 9.77 KIT
36 Increased cell migration GR00055-A-3 9.55 EGFR DDR2 HRAS KRAS PIK3CA
37 Increased transferrin (TF) endocytosis GR00363-A 9.28 DDR2 ALK EGFR FBXW7 KIT HRAS

MGI Mouse Phenotypes related to Lung Adenoid Cystic Carcinoma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.3 FBXW7 EGFR ALK DDR2 KRAS KIT
2 growth/size/body region MP:0005378 10.29 DDR2 FBXW7 ALK EGFR HRAS KRAS
3 homeostasis/metabolism MP:0005376 10.28 DDR2 ALK EGFR HRAS KRAS FBXW7
4 cardiovascular system MP:0005385 10.24 DDR2 EGFR HRAS KRAS FBXW7 KIT
5 mortality/aging MP:0010768 10.24 DDR2 ALK EGFR HRAS KRAS FBXW7
6 cellular MP:0005384 10.19 EGFR DDR2 FBXW7 KIT PDGFRA NKX2-1
7 craniofacial MP:0005382 10.18 FBXW7 EGFR DDR2 KRAS KIT HRAS
8 integument MP:0010771 10.18 FBXW7 ALK EGFR DDR2 KRAS KIT
9 digestive/alimentary MP:0005381 10.17 FBXW7 EGFR HRAS KRAS KIT NKX2-1
10 nervous system MP:0003631 10.17 FBXW7 EGFR ALK DDR2 KRAS KIT
11 neoplasm MP:0002006 10.16 FBXW7 EGFR ALK DDR2 KIT HRAS
12 no phenotypic analysis MP:0003012 10.01 DDR2 EGFR HRAS KRAS KIT NKX2-1
13 muscle MP:0005369 9.95 EGFR DDR2 KIT PDGFRA KRAS PIK3CA
14 limbs/digits/tail MP:0005371 9.91 EGFR DDR2 KIT PDGFRA KRAS
15 normal MP:0002873 9.91 EGFR HRAS FBXW7 KIT PDGFRA NKX2-1
16 reproductive system MP:0005389 9.86 DDR2 ALK EGFR KRAS KIT NKX2-1
17 respiratory system MP:0005388 9.81 FBXW7 EGFR ALK KRAS KIT HRAS
18 pigmentation MP:0001186 9.72 ALK EGFR KRAS KIT PDGFRA
19 skeleton MP:0005390 9.61 DDR2 ALK EGFR HRAS KRAS KIT
20 vision/eye MP:0005391 9.23 DDR2 ALK EGFR KRAS FBXW7 KIT

Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Adenoid Cystic Carcinoma

Genetic Tests for Lung Adenoid Cystic Carcinoma

Anatomical Context for Lung Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Lung Adenoid Cystic Carcinoma:

41
Lung

Publications for Lung Adenoid Cystic Carcinoma

Articles related to Lung Adenoid Cystic Carcinoma:

# Title Authors Year
1
Primary Mediastinal Synovial Sarcoma with subsequent development of Primary Adenoid Cystic Carcinoma of Lung presenting as superior vena cava syndrome. ( 26992072 )
2016
2
Primary adenoid cystic carcinoma of lung: a case report and review of the literature. ( 23771382 )
2013

Variations for Lung Adenoid Cystic Carcinoma

Cosmic variations for Lung Adenoid Cystic Carcinoma:

9
(show top 50) (show all 548)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 7
2 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 7
3 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 7
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 7
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 7
6 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 7
7 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 7
8 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 7
9 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 7
10 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 7
11 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 7
12 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 7
13 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 7
14 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 7
15 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 7
16 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 7
17 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 7
18 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 7
19 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 7
20 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 7
21 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 7
22 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 7
23 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 7
24 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 7
25 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 7
26 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 7
27 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 7
28 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 7
29 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 7
30 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 7
31 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 7
32 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 7
33 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 7
34 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 7
35 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 7
36 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 7
37 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 7
38 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 7
39 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 7
40 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 7
41 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 7
42 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 7
43 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 7
44 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 7
45 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 7
46 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 7
47 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 7
48 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 7
49 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 7
50 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 7

Expression for Lung Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.

Pathways for Lung Adenoid Cystic Carcinoma

Pathways related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 ALK DDR2 EGFR HRAS KIT KRAS
2
Show member pathways
13.66 EGFR FBXW7 HRAS KIT KRAS PDGFRA
3
Show member pathways
13.62 ALK DDR2 EGFR HRAS KIT KRAS
4
Show member pathways
13.51 ALK DDR2 EGFR HRAS KIT KRAS
5
Show member pathways
13.45 EGFR HRAS KIT KRAS PDGFRA PIK3CA
6
Show member pathways
13.45 ALK DDR2 EGFR HRAS KIT KRAS
7
Show member pathways
13.41 EGFR FBXW7 HRAS KIT KRAS PDGFRA
8
Show member pathways
13.36 ALK DDR2 EGFR HRAS KIT KRAS
9
Show member pathways
13.31 EGFR HRAS KIT KRAS PDGFRA PIK3CA
10
Show member pathways
13.27 ALK DDR2 EGFR HRAS KIT KRAS
11
Show member pathways
13.2 ALK DDR2 EGFR HRAS KIT KRAS
12
Show member pathways
13.02 EGFR HRAS KIT KRAS PDGFRA
13
Show member pathways
12.93 ALK DDR2 EGFR KIT PDGFRA
14
Show member pathways
12.93 EGFR HRAS KIT KRAS PDGFRA PIK3CA
15
Show member pathways
12.9 EGFR HRAS KIT KRAS PDGFRA PIK3CA
16
Show member pathways
12.87 EGFR HRAS KRAS PDGFRA PIK3CA
17
Show member pathways
12.86 ALK DDR2 EGFR HRAS KIT KRAS
18
Show member pathways
12.84 EGFR HRAS KRAS PDGFRA PIK3CA
19
Show member pathways
12.79 EGFR HRAS KIT KRAS PDGFRA PIK3CA
20 12.75 EGFR HRAS KIT KRAS PDGFRA
21
Show member pathways
12.74 EGFR HRAS KIT KRAS PIK3CA
22
Show member pathways
12.64 EGFR HRAS KRAS PIK3CA
23
Show member pathways
12.63 EGFR HRAS KRAS PDGFRA
24
Show member pathways
12.61 EGFR HRAS PDGFRA PIK3CA
25 12.61 EGFR HRAS KRAS PDGFRA PIK3CA
26
Show member pathways
12.61 EGFR HRAS KIT KRAS PDGFRA PIK3CA
27
Show member pathways
12.59 EGFR HRAS KIT KRAS PDGFRA PIK3CA
28
Show member pathways
12.56 EGFR HRAS KRAS PDGFRA PIK3CA
29
Show member pathways
12.51 EGFR HRAS KRAS PIK3CA
30 12.47 EGFR HRAS KRAS PDGFRA PIK3CA
31
Show member pathways
12.46 EGFR HRAS KRAS PIK3CA
32
Show member pathways
12.44 EGFR HRAS KRAS PDGFRA PIK3CA
33 12.41 HRAS KRAS PDGFRA PIK3CA
34
Show member pathways
12.39 EGFR HRAS KRAS PIK3CA
35
Show member pathways
12.38 EGFR HRAS KRAS PDGFRA PIK3CA
36
Show member pathways
12.37 ALK EGFR EML4 HRAS KRAS PDGFRA
37
Show member pathways
12.32 EGFR HRAS PDGFRA PIK3CA
38
Show member pathways
12.31 EGFR HRAS KRAS PIK3CA
39 12.29 EGFR HRAS KRAS PIK3CA
40 12.28 ALK EGFR EML4 HRAS KIT KRAS
41
Show member pathways
12.21 HRAS KRAS PIK3CA
42
Show member pathways
12.2 EGFR HRAS KRAS
43 12.19 HRAS KRAS PIK3CA
44
Show member pathways
12.19 HRAS KRAS PIK3CA
45 12.16 EGFR HRAS KRAS
46
Show member pathways
12.15 HRAS KIT PIK3CA
47
Show member pathways
12.15 HRAS KRAS PIK3CA
48 12.15 HRAS KRAS PIK3CA
49
Show member pathways
12.14 HRAS KRAS PIK3CA
50
Show member pathways
12.12 EGFR HRAS KIT KRAS PDGFRA PIK3CA

GO Terms for Lung Adenoid Cystic Carcinoma

Cellular components related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.65 ALK DDR2 EGFR EML4 FBXW7 HRAS
2 receptor complex GO:0043235 9.02 ALK DDR2 EGFR KIT PDGFRA

Biological processes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 DDR2 EGFR HRAS KIT KRAS PDGFRA
2 positive regulation of gene expression GO:0010628 9.96 HRAS KIT KRAS NKX2-1
3 MAPK cascade GO:0000165 9.92 EGFR HRAS KIT KRAS PDGFRA
4 positive regulation of cell migration GO:0030335 9.91 EGFR HRAS KIT PDGFRA
5 axon guidance GO:0007411 9.89 HRAS KRAS NKX2-1 PIK3CA
6 positive regulation of protein kinase B signaling GO:0051897 9.87 EGFR KIT PDGFRA PIK3CA
7 positive regulation of protein phosphorylation GO:0001934 9.85 EGFR HRAS KRAS
8 negative regulation of neuron apoptotic process GO:0043524 9.84 HRAS KRAS PIK3CA
9 phosphatidylinositol phosphorylation GO:0046854 9.84 EGFR KIT PDGFRA PIK3CA
10 animal organ morphogenesis GO:0009887 9.83 HRAS NKX2-1 PDGFRA
11 protein autophosphorylation GO:0046777 9.83 ALK DDR2 EGFR KIT PDGFRA
12 liver development GO:0001889 9.81 EGFR KRAS PIK3CA
13 lung development GO:0030324 9.81 EGFR NFIB NKX2-1 PDGFRA
14 cell chemotaxis GO:0060326 9.8 KIT PDGFRA PIK3CA
15 peptidyl-tyrosine phosphorylation GO:0018108 9.8 ALK DDR2 EGFR KIT PDGFRA
16 positive regulation of MAP kinase activity GO:0043406 9.78 EGFR HRAS KIT KRAS
17 positive regulation of fibroblast proliferation GO:0048146 9.77 DDR2 EGFR PDGFRA
18 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.77 ALK DDR2 EGFR KIT PDGFRA
19 epidermal growth factor receptor signaling pathway GO:0007173 9.76 EGFR HRAS KRAS PIK3CA
20 positive regulation of DNA replication GO:0045740 9.75 EGFR HRAS PDGFRA
21 vasculature development GO:0001944 9.68 FBXW7 PIK3CA
22 regulation of long-term neuronal synaptic plasticity GO:0048169 9.67 HRAS KRAS
23 epithelial tube branching involved in lung morphogenesis GO:0060441 9.66 KRAS NKX2-1
24 cerebral cortex cell migration GO:0021795 9.65 EGFR NKX2-1
25 tongue development GO:0043586 9.65 EGFR KIT
26 negative regulation of signal transduction GO:0009968 9.65 ALK DDR2 EGFR KIT PDGFRA
27 Leydig cell differentiation GO:0033327 9.64 NKX2-1 PDGFRA
28 positive regulation of phospholipase C activity GO:0010863 9.63 KIT PDGFRA
29 response to isolation stress GO:0035900 9.62 HRAS KRAS
30 ERBB2 signaling pathway GO:0038128 9.62 EGFR HRAS KRAS PIK3CA
31 Type II pneumocyte differentiation GO:0060510 9.61 NFIB NKX2-1
32 Clara cell differentiation GO:0060486 9.58 NFIB NKX2-1
33 positive regulation of kinase activity GO:0033674 9.55 ALK DDR2 EGFR KIT PDGFRA
34 positive regulation of MAPK cascade GO:0043410 9.43 ALK DDR2 EGFR HRAS KIT PDGFRA
35 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.17 ALK DDR2 EGFR FBXW7 HRAS KIT
36 cell differentiation GO:0030154 10.08 ALK DDR2 EGFR KIT PDGFRA
37 phosphorylation GO:0016310 10.03 ALK DDR2 EGFR KIT PDGFRA PIK3CA
38 negative regulation of apoptotic process GO:0043066 10.02 ALK DDR2 EGFR KIT PDGFRA
39 protein phosphorylation GO:0006468 10.02 ALK DDR2 EGFR KIT PDGFRA PIK3CA

Molecular functions related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.99 ALK DDR2 EGFR KIT PDGFRA PIK3CA
2 protein kinase activity GO:0004672 9.85 ALK DDR2 EGFR KIT PDGFRA
3 kinase activity GO:0016301 9.85 ALK DDR2 EGFR KIT PDGFRA PIK3CA
4 nucleotide binding GO:0000166 9.83 EGFR HRAS KIT KRAS PDGFRA
5 transmembrane signaling receptor activity GO:0004888 9.8 ALK DDR2 EGFR KIT PDGFRA
6 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.67 EGFR KIT PDGFRA
7 protein tyrosine kinase activity GO:0004713 9.65 ALK DDR2 EGFR KIT PDGFRA
8 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.62 EGFR KIT PDGFRA PIK3CA
9 MAP kinase kinase kinase activity GO:0004709 9.55 ALK DDR2 EGFR KIT PDGFRA
10 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.48 EGFR KIT
11 mitogen-activated protein kinase kinase binding GO:0031434 9.35 ALK DDR2 EGFR KIT PDGFRA
12 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 ALK DDR2 EGFR KIT PDGFRA

Sources for Lung Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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