MCID: LNG011
MIFTS: 35

Lung Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Lung Adenoid Cystic Carcinoma

MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma 11 14
Adenoid Cystic Carcinoma of Lung 11 71
Pulmonary Adenoid Cystic Carcinoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4872
NCIt 49 C5666
UMLS 71 C1334439

Summaries for Lung Adenoid Cystic Carcinoma

MalaCards based summary: Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to heart cancer and brooke-spiegler syndrome, and has symptoms including hemoptysis, dyspnea and chest pain. An important gene associated with Lung Adenoid Cystic Carcinoma is NFIB (Nuclear Factor I B), and among its related pathways/superpathways are AP-1 transcription factor network and Pathways affected in adenoid cystic carcinoma. Affiliated tissues include lung, salivary gland and kidney, and related phenotypes are Decreased viability in pancreas lineage and endocrine/exocrine gland

Related Diseases for Lung Adenoid Cystic Carcinoma

Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 heart cancer 30.2 KRT7 KIT
2 brooke-spiegler syndrome 30.2 NFIB KRT7
3 adenoid cystic carcinoma 29.9 NFIB MYBL1 MYB KRT7 KIT
4 mucoepidermoid carcinoma 29.9 MAML2 KRT7 CRTC1
5 salivary gland adenoid cystic carcinoma 29.8 NFIB MYBL1 KRT7 KIT
6 lung cancer 10.3
7 rare tumor 10.3
8 adrenocortical carcinoma, hereditary 10.2
9 factor vii deficiency 10.2
10 small cell carcinoma 10.2
11 synchronous bilateral breast carcinoma 10.2 NFIB KIT
12 large intestine lipoma 10.2 NFIB KIT
13 lipoma of colon 10.2 NFIB KIT
14 sublingual gland adenoid cystic carcinoma 10.2 NFIB KRT7
15 sublingual gland cancer 10.1 NFIB KRT7
16 aggressive digital papillary adenocarcinoma 10.1 MAML2 KRT7
17 malignant acrospiroma 10.1 MAML2 KRT7
18 laryngeal adenoid cystic carcinoma 10.1 KRT7 KIT
19 spiradenoma 10.1 NFIB KRT7
20 breast hemangiopericytoma 10.1 KRT7 KIT
21 apocrine sweat gland neoplasm 10.1 NFIB KRT7
22 adenoid basal cell carcinoma 10.1 KRT7 KIT
23 eosinophilic variant of chromophobe renal cell carcinoma 10.1 KRT7 KIT
24 intratubular embryonal carcinoma 10.1 KRT7 KIT
25 jejunal neoplasm 10.1 KRT7 KIT
26 eccrine sweat gland cancer 10.1 MAML2 KRT7
27 ureter small cell carcinoma 10.1 KRT7 KIT
28 sarcoma, synovial 10.1
29 sarcoma 10.1
30 kidney cancer 10.1
31 soft tissue sarcoma 10.1
32 bilateral hypoactive labyrinth 10.1 KRT7 KIT
33 sarcomatoid renal cell carcinoma 10.1 KRT7 KIT
34 ceruminoma 10.1 MYBL1 KRT7
35 breast leiomyosarcoma 10.1 KRT7 KIT
36 eccrine porocarcinoma 10.1 MAML2 KRT7
37 liver sarcoma 10.1 KRT7 KIT
38 thymus large cell carcinoma 10.1 KRT7 KIT
39 mediastinum sarcoma 10.1 KRT7 KIT
40 eccrine adenocarcinoma 10.1 MYBL1 KRT7
41 lymphoepithelioma-like carcinoma 10.1 KRT7 KIT
42 basaloid squamous cell carcinoma 10.1 KRT7 KIT
43 lacrimal gland carcinoma 10.1 NFIB KRT7
44 mediastinal cancer 10.1 KRT7 KIT
45 mixed germ cell cancer 10.1 KRT7 KIT
46 tibial adamantinoma 10.1 KRT7 KIT
47 bronchial disease 10.1
48 tracheal disease 10.1
49 virus-associated trichodysplasia spinulosa 10.1
50 ovarian germ cell cancer 10.1 KRT7 KIT

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:



Diseases related to Lung Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

UMLS symptoms related to Lung Adenoid Cystic Carcinoma:


hemoptysis; dyspnea; chest pain; pain; wheezing; coughing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in pancreas lineage GR00235-A 8.62 KRT7 MYBL1

MGI Mouse Phenotypes related to Lung Adenoid Cystic Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 CRTC1 DDR2 KIT MYB MYBL1 NFIB

Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

Search Clinical Trials, NIH Clinical Center for Lung Adenoid Cystic Carcinoma

Genetic Tests for Lung Adenoid Cystic Carcinoma

Anatomical Context for Lung Adenoid Cystic Carcinoma

Organs/tissues related to Lung Adenoid Cystic Carcinoma:

MalaCards : Lung, Salivary Gland, Kidney, Tongue

Publications for Lung Adenoid Cystic Carcinoma

Articles related to Lung Adenoid Cystic Carcinoma:

(show all 47)
# Title Authors PMID Year
1
Clinical, laboratory, pathological, and radiological characteristics and prognosis of patients with pulmonary salivary gland-type tumors. 62
36038675 2022
2
Adenoid Cystic Carcinoma of Lobar Bronchial Origin: 20-Year Experience at a Single Institution. 62
35355128 2022
3
Pulmonary Adenoid Cystic Carcinoma Presenting Late With Intrapericardial Extension: Case Report. 62
35199056 2022
4
Bilateral kidney metastases from adenoid cystic carcinoma of lung: a case report and literature review. 62
33686592 2021
5
Pulmonary Cylindromas in CYLD Cutaneous Syndrome: A Rare Differential Diagnosis of Pulmonary Adenoid Cystic Carcinoma. 62
33896728 2021
6
A Rare Case of Primary Pulmonary Adenoid Cystic Carcinoma and the Diagnostic Challenges on Cytology. 62
34449997 2021
7
A Delicate Surgical Resection to Treat a Proximal Pulmonary Adenoid Cystic Carcinoma. 62
34306791 2021
8
Case Report: Efficacy of Pyrotinib in ERBB2 Amplification Pulmonary Adenoid Cystic Carcinoma. 62
33816237 2021
9
Multi-Omics Characterization and Origin Assessment of Bilateral Lung Adenoid Cystic Carcinoma: A Case Report. 62
33664590 2021
10
Solitary Renal Metastasis Arising from a Pulmonary Adenoid Cystic Carcinoma: A Case Report and Review of the Literature. 62
33859861 2021
11
[Clinicopathological features of lung salivary gland-type tumors]. 62
31818065 2019
12
An unusual case report of pulmonary adenoid cystic carcinoma metastasis to the kidney. Case report and literature review. 62
31687358 2019
13
Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection. 62
31067606 2019
14
[Clinicopathological features and prognostic factors of primary pulmonary adenoid cystic carcinoma: a study of 59 cases]. 62
30831646 2019
15
A series of patients with unusual lung cancers with unusual presentations. 62
34286251 2019
16
CT features and differential diagnosis of primary pulmonary mucoepidermoid carcinoma and pulmonary adenoid cystic carcinoma. 62
30746194 2018
17
[The clinicopathological features and curative effect of the bronchoscopic interventional therapy combined with radiotherapy for the treatment of locally recurrent lung adenoid cystic carcinoma]. 62
30481940 2018
18
Isolated splenic metastasis from pulmonary adenoid cystic carcinoma. 62
29474653 2018
19
Effects of para-toluenesulfonamide intratumoral injection on pulmonary adenoid cystic carcinoma complicating with severe central airway obstruction: a 5-year follow-up study. 62
29850151 2018
20
Mutational landscape and clonal diversity of pulmonary adenoid cystic carcinoma. 62
30067437 2018
21
Primary mediastinal synovial sarcoma with subsequent development of primary adenoid cystic carcinoma of lung presenting as superior vena cava syndrome. 62
26992072 2018
22
A Comparative Study of Primary Adenoid Cystic and Mucoepidermoid Carcinoma of Lung. 62
29868475 2018
23
[Four Cases Report on Primary Lung Adenoid Cystic Carcinoma]. 62
29167011 2017
24
Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma. 62
26477588 2015
25
Histopathologic and Cytogenetic Features of Pulmonary Adenoid Cystic Carcinoma. 62
26309189 2015
26
Molecular genetic studies on EGFR, KRAS, BRAF, ALK, PIK3CA, PDGFRA, and DDR2 in primary pulmonary adenoid cystic carcinoma. 62
26373952 2015
27
Primary pulmonary adenoid cystic carcinoma: clinicopathological analyses of 12 cases. 62
26261681 2015
28
Metachronous adenoid cystic carcinoma in the peripheral lung and at base of the tongue. 62
25177443 2014
29
A rare case of primary adenoid cystic carcinoma of lung. 62
25823114 2014
30
Primary adenoid cystic carcinoma of lung: a case report and review of the literature. 62
23771382 2013
31
Primary pulmonary adenoid cystic carcinoma: report of two cases. 62
23087312 2012
32
Primary peripheral pulmonary adenoid cystic carcinoma: report of a case diagnosed by fine needle aspiration cytology. 62
20607807 2011
33
Thoracoscopic management including lobectomy for a primary peripheral pulmonary adenoid cystic carcinoma in a cirrhotic patient. 62
20975497 2010
34
[Recurrent adenoid cystic carcinoma. Review based on a case report]. 62
19145392 2009
35
Unusual lung mass: benign or malignant? 62
19035058 2008
36
[Atypically located pulmonary adenoid cystic carcinoma: case report]. 62
18701983 2008
37
Palliative radiotherapy in a patient with pulmonary adenoid cystic carcinoma. 62
19746187 2007
38
Diagnosis of adenoid cystic carcinoma of the lung by bronchial brushing: a case report. 62
17718122 2007
39
Metastatic adenoid cystic carcinoma of lung: a case report. 62
17183870 2006
40
Primary pulmonary adenoid cystic carcinoma: report of a case diagnosed by fine-needle aspiration cytology. 62
14696146 2004
41
Recurrent pulmonary adenoid cystic carcinoma presenting as a cardiac tumor. 62
10748314 2000
42
Pancoast syndrome: an unusual presentation of adenoid cystic carcinoma. 62
8383065 1993
43
[Bilateral renal metastases of lung adenoid cystic carcinoma]. 62
1661561 1991
44
The use of fine-needle aspiration in the diagnosis of metastatic pulmonary adenoid cystic carcinoma. 62
1645465 1991
45
Peripheral pulmonary adenoid cystic carcinoma with substantial submucosal extension to the proximal bronchus. 62
1849668 1991
46
Atypical manifestations of pulmonary adenoid cystic carcinoma. 62
3040062 1986
47
Cerebral gliosarcoma, pulmonary adenoid-cystic carcinoma, and pulmonary metastatic gliosarcoma: report of an untreated case. 62
6087260 1984

Variations for Lung Adenoid Cystic Carcinoma

Cosmic variations for Lung Adenoid Cystic Carcinoma:

8 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM102042323 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8009A>G p.? 16:72958974-72958974 5
2 COSM87291734 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 5
3 COSM102040476 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8037G>T p.? 16:72959002-72959002 5
4 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 5
5 COSM87290218 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 5
6 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 5
7 COSM126973051 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.770C>T p.P257L 11:102229729-102229729 5
8 COSM145028029 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1154C>T p.P385L 11:102229729-102229729 5
9 COSM128452039 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 5
10 COSM85237448 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1304C>T p.P435L 11:102229729-102229729 5
11 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 5
12 COSM127997731 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1256C>T p.P419L 11:102229729-102229729 5
13 COSM133274224 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1268C>T p.P423L 11:102229729-102229729 5
14 COSM90948266 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1202C>T p.P401L 11:102229729-102229729 5
15 COSM108017622 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 5
16 COSM95166535 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 5
17 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 5
18 COSM105839764 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 5
19 COSM106337415 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 5
20 COSM103711109 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1036A>C p.I346L 22:41653558-41653558 5
21 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 5
22 COSM134125623 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1114A>G p.M372V 19:43546970-43546970 5
23 COSM100781761 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.724A>T p.K242* 11:32392044-32392044 5
24 COSM111539040 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 5
25 COSM149728755 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 5
26 COSM130518653 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.673A>T p.K225* 11:32392044-32392044 5
27 COSM113475703 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 5
28 COSM111529696 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 5
29 COSM113484991 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 5
30 COSM147414475 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 5
31 COSM149739953 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 5
32 COSM148580942 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 5
33 COSM148593279 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 5
34 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 5
35 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 5
36 COSM147426277 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 5
37 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 5
38 COSM104050903 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 5
39 COSM105123686 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 5
40 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 5
41 COSM102763785 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 5
42 COSM99767946 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 5
43 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 5
44 COSM121848752 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 5
45 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 5
46 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 5
47 COSM99795256 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 5
48 COSM143996084 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1620C>G p.F540L 19:4947122-4947122 5
49 COSM143964403 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1428C>G p.F476L 19:4947122-4947122 5
50 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 5

Expression for Lung Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.

Pathways for Lung Adenoid Cystic Carcinoma

Pathways related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 MYB CRTC1
2 10.59 NFIB MYBL1 MYB

GO Terms for Lung Adenoid Cystic Carcinoma

Sources for Lung Adenoid Cystic Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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