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MCID: LNG011
MIFTS: 42

Lung Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Lung Adenoid Cystic Carcinoma

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MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Lung 12 73
Pulmonary Adenoid Cystic Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4872
NCIt 50 C5666
UMLS 73 C1334439
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Summaries for Lung Adenoid Cystic Carcinoma

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MalaCards based summary : Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to small cell carcinoma and sarcoma, and has symptoms including dyspnea, hemoptysis and pain. An important gene associated with Lung Adenoid Cystic Carcinoma is DDR2 (Discoidin Domain Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are GPCR Pathway and PEDF Induced Signaling. Affiliated tissues include lung, bone and ovary, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Lung Adenoid Cystic Carcinoma

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Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.3 KIT NKX2-1 PDGFRA
2 sarcoma 29.4 HRAS KIT KRAS PIK3CA
3 adenoid cystic carcinoma 29.4 HRAS KIT KRAS NFIB PIK3CA
4 pleomorphic carcinoma 10.2 ALK NKX2-1
5 clear cell adenofibroma 10.2 PDGFRA PIK3CA
6 neurofibromatosis, type i 10.2 KIT PDGFRA
7 reticular perineurioma 10.2 KIT PDGFRA
8 sm-ahnmd 10.1 KIT PDGFRA
9 gastric leiomyosarcoma 10.1 KIT PDGFRA
10 perineurioma 10.1 ALK KIT
11 conventional fibrosarcoma 10.1 KIT PDGFRA
12 rete testis adenocarcinoma 10.1 KIT NKX2-1
13 endometrial small cell carcinoma 10.1 KIT PDGFRA
14 desmoid tumor 10.1 KIT PDGFRA
15 hypereosinophilic syndrome, idiopathic 10.1 KIT PDGFRA
16 lung papillary adenocarcinoma 10.1 ALK EML4
17 prostate small cell carcinoma 10.1 KIT NKX2-1
18 pulmonary vein stenosis 10.1 KIT PDGFRA
19 carney triad 10.1 KIT PDGFRA
20 heart sarcoma 10.1 KIT PDGFRA
21 rete testis neoplasm 10.1 KIT NKX2-1
22 chronic eosinophilic leukemia 10.1 KIT PDGFRA
23 breast adenoid cystic carcinoma 10.1 KIT NFIB
24 respiratory system benign neoplasm 10.1 KRAS NKX2-1
25 papillary hidradenoma 10.1 KIT PIK3CA
26 mast-cell leukemia 10.1 KIT PIK3CA
27 rare adenocarcinoma of the breast 10.1 KRAS PIK3CA
28 alveoli adenoma 10.1 KRAS NKX2-1
29 pulmonary blastoma 10.1 KRAS NKX2-1
30 childhood kidney cell carcinoma 10.1 ALK EML4
31 rosai-dorfman disease 10.1 KRAS PDGFRA
32 large cell neuroendocrine carcinoma 10.1 KIT NKX2-1
33 chromosome 14q11-q22 deletion syndrome 10.0 HRAS NKX2-1
34 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.0 KRAS PIK3CA
35 cavernous hemangioma 10.0 KIT NKX2-1 PDGFRA
36 malignant struma ovarii 10.0 HRAS NKX2-1
37 mesenchymal cell neoplasm 10.0 ALK KIT PDGFRA
38 fetal adenoma 10.0 HRAS NKX2-1
39 polymorphous low-grade adenocarcinoma 10.0 KIT NFIB
40 sarcoma, synovial 10.0
41 prostate adenoid cystic carcinoma 10.0 HRAS PIK3CA
42 spinal chordoma 10.0 PDGFRA PIK3CA
43 ethmoid sinus cancer 10.0 HRAS PIK3CA
44 gliosarcoma 10.0
45 small cell cancer of the lung 10.0 KIT NKX2-1 PIK3CA
46 ethmoid sinus adenocarcinoma 10.0 HRAS PIK3CA
47 mucinous adenocarcinoma 10.0 ALK KRAS NKX2-1
48 tonsil cancer 10.0 KIT NFIB
49 thymoma, familial 10.0 HRAS KIT
50 ovarian melanoma 10.0 HRAS KIT

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:



Diseases related to Lung Adenoid Cystic Carcinoma
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Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

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UMLS symptoms related to Lung Adenoid Cystic Carcinoma:


dyspnea, hemoptysis, pain, chest pain, wheezing, coughing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.79 HRAS KRAS PIK3CA
2 Decreased viability GR00106-A-0 10.79 KRAS
3 Decreased viability GR00173-A 10.79 PDGFRA
4 Decreased viability GR00221-A-1 10.79 HRAS KRAS PIK3CA DDR2 ALK PDGFRA
5 Decreased viability GR00221-A-2 10.79 HRAS KRAS PIK3CA DDR2
6 Decreased viability GR00221-A-3 10.79 HRAS PDGFRA
7 Decreased viability GR00221-A-4 10.79 PIK3CA DDR2 ALK PDGFRA
8 Decreased viability GR00301-A 10.79 KRAS KIT
9 Decreased viability GR00381-A-1 10.79 KRAS
10 Decreased viability GR00402-S-2 10.79 HRAS KRAS PIK3CA DDR2 ALK PDGFRA
11 Decreased cell migration GR00055-A-1 9.65 ALK DDR2 HRAS KRAS PIK3CA
12 Decreased viability in esophageal squamous lineage GR00235-A 9.56 DDR2 HRAS KIT KRAS NFIB NKX2-1
13 Increased cell migration GR00055-A-3 8.92 DDR2 HRAS KRAS PIK3CA

MGI Mouse Phenotypes related to Lung Adenoid Cystic Carcinoma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.18 ALK DDR2 HRAS KIT KRAS NFIB
2 growth/size/body region MP:0005378 10.16 ALK DDR2 HRAS KIT KRAS NFIB
3 homeostasis/metabolism MP:0005376 10.15 ALK DDR2 HRAS KIT KRAS NFIB
4 behavior/neurological MP:0005386 10.11 ALK HRAS KIT KRAS NKX2-1 PDGFRA
5 mortality/aging MP:0010768 10.11 ALK DDR2 HRAS KIT KRAS NFIB
6 cardiovascular system MP:0005385 10.1 DDR2 HRAS KIT KRAS NKX2-1 PDGFRA
7 nervous system MP:0003631 10.06 ALK DDR2 HRAS KIT KRAS NFIB
8 neoplasm MP:0002006 10.03 ALK DDR2 HRAS KIT KRAS NKX2-1
9 craniofacial MP:0005382 10.02 DDR2 HRAS KIT KRAS NFIB PDGFRA
10 integument MP:0010771 10.02 ALK DDR2 HRAS KIT KRAS PDGFRA
11 digestive/alimentary MP:0005381 10.01 HRAS KIT KRAS NFIB NKX2-1 PDGFRA
12 no phenotypic analysis MP:0003012 9.91 DDR2 HRAS KIT KRAS NKX2-1 PDGFRA
13 reproductive system MP:0005389 9.8 ALK DDR2 KIT KRAS NKX2-1 PDGFRA
14 respiratory system MP:0005388 9.7 ALK HRAS KIT KRAS NFIB NKX2-1
15 pigmentation MP:0001186 9.62 ALK KIT KRAS PDGFRA
16 skeleton MP:0005390 9.56 ALK DDR2 HRAS KIT KRAS NKX2-1
17 vision/eye MP:0005391 9.1 ALK DDR2 KIT KRAS NFIB PIK3CA
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Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

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Search Clinical Trials , NIH Clinical Center for Lung Adenoid Cystic Carcinoma

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Genetic Tests for Lung Adenoid Cystic Carcinoma

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Anatomical Context for Lung Adenoid Cystic Carcinoma

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MalaCards organs/tissues related to Lung Adenoid Cystic Carcinoma:

41
Lung, Bone, Ovary, Pancreas, Thyroid, Testis, Myeloid
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Publications for Lung Adenoid Cystic Carcinoma

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Articles related to Lung Adenoid Cystic Carcinoma:

# Title Authors Year
1
Primary Mediastinal Synovial Sarcoma with subsequent development of Primary Adenoid Cystic Carcinoma of Lung presenting as superior vena cava syndrome. ( 26992072 )
2016
2
A rare case of primary adenoid cystic carcinoma of lung. ( 25823114 )
2014
3
Primary adenoid cystic carcinoma of lung: a case report and review of the literature. ( 23771382 )
2013
4
Metastatic adenoid cystic carcinoma of lung: a case report. ( 17183870 )
2006
Sources

Variations for Lung Adenoid Cystic Carcinoma

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Cosmic variations for Lung Adenoid Cystic Carcinoma:

9 (show top 50) (show all 548)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 7
2 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 7
3 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 7
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 7
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 7
6 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 7
7 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 7
8 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 7
9 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 7
10 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 7
11 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 7
12 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 7
13 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 7
14 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 7
15 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 7
16 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 7
17 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 7
18 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 7
19 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 7
20 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 7
21 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 7
22 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 7
23 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 7
24 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 7
25 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 7
26 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 7
27 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 7
28 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 7
29 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 7
30 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 7
31 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 7
32 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 7
33 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 7
34 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 7
35 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 7
36 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 7
37 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 7
38 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 7
39 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 7
40 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 7
41 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 7
42 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 7
43 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 7
44 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 7
45 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 7
46 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 7
47 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 7
48 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 7
49 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 7
50 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 7
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Expression for Lung Adenoid Cystic Carcinoma

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Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.
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Pathways for Lung Adenoid Cystic Carcinoma

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Pathways related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
GPCR Pathway 64
Show member pathways
 13.61 ALK DDR2 HRAS KIT KRAS PDGFRA
2
PEDF Induced Signaling 64
Show member pathways
 13.57 ALK DDR2 HRAS KIT KRAS PDGFRA
3
Activation of cAMP-Dependent PKA 64
Show member pathways
 13.43 ALK DDR2 HRAS KIT KRAS PDGFRA
4
TGF-Beta Pathway 64
Show member pathways
 13.33 ALK DDR2 HRAS KIT KRAS PDGFRA
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.27 HRAS KIT KRAS PDGFRA PIK3CA
6
Akt Signaling 64
Show member pathways
 13.27 ALK DDR2 HRAS KIT KRAS PDGFRA
7
CREB Pathway 64
Show member pathways
 13.14 ALK DDR2 HRAS KIT KRAS PDGFRA
8
Nanog in Mammalian ESC Pluripotency 64
Show member pathways
 13.09 ALK DDR2 HRAS KIT KRAS PDGFRA
9
Actin Nucleation by ARP-WASP Complex 64
Show member pathways
 12.86 ALK DDR2 HRAS KIT PDGFRA
10
PI3K-Akt signaling pathway 37
Show member pathways
 12.86 HRAS KIT KRAS PDGFRA PIK3CA
11
Focal Adhesion 1 37
Show member pathways
 12.82 HRAS KRAS PDGFRA PIK3CA
12
Development Angiotensin activation of ERK 22
Show member pathways
 12.8 HRAS KIT KRAS PDGFRA PIK3CA
13
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.78 HRAS KRAS PDGFRA PIK3CA
14
p70S6K Signaling 64
Show member pathways
 12.76 ALK DDR2 HRAS KIT KRAS PDGFRA
15
Endometrial cancer 37
Show member pathways
 12.7 HRAS KIT KRAS PDGFRA PIK3CA
16
MAPK signaling pathway 37 1
12.68 HRAS KIT KRAS PDGFRA
17
Gastric cancer 37
Show member pathways
 12.67 HRAS KIT KRAS PIK3CA
18
Ras signaling pathway 37
Show member pathways
 12.55 HRAS KIT KRAS PDGFRA PIK3CA
19
Regulation of actin cytoskeleton 1 37
12.53 HRAS KRAS PDGFRA PIK3CA
20
Downstream signaling events of B Cell Receptor (BCR) 66
Show member pathways
 12.53 HRAS KIT KRAS PDGFRA PIK3CA
21
Immune response IL-23 signaling pathway 22
Show member pathways
 12.5 HRAS KRAS PDGFRA PIK3CA
22
Pathways in cancer 37
12.42 ALK EML4 HRAS KIT KRAS PDGFRA
23
MicroRNAs in cancer 37
12.41 HRAS KRAS PDGFRA PIK3CA
24
Glioma 37
Show member pathways
 12.41 ALK EML4 HRAS KRAS PDGFRA PIK3CA
25
mTOR signaling pathway (KEGG) 65
Show member pathways
 12.39 HRAS KRAS PDGFRA PIK3CA
26
Apoptosis Pathway 72
Show member pathways
 12.32 HRAS KRAS PDGFRA PIK3CA
27
B cell receptor signaling pathway (KEGG) 37
Show member pathways
 12.31 HRAS KRAS PIK3CA
28
MET promotes cell motility 66
Show member pathways
 12.29 HRAS KRAS PIK3CA
29
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.29 HRAS KRAS PDGFRA PIK3CA
30
Human T-cell leukemia virus 1 infection 37
12.29 HRAS KRAS PDGFRA PIK3CA
31
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.26 HRAS PDGFRA PIK3CA
32
B Cell Receptor Signaling Pathway (sino) 67
Show member pathways
 12.26 HRAS KRAS PIK3CA
33
Signaling by ERBB2 66
Show member pathways
 12.25 HRAS KRAS PIK3CA
34
Proteoglycans in cancer 37
12.23 HRAS KRAS PIK3CA
35
Viral carcinogenesis 37
12.23 HRAS KRAS PIK3CA
36
Signaling by FGFR2 66
Show member pathways
 12.21 HRAS KRAS PIK3CA
37
Cell surface interactions at the vascular wall 66
Show member pathways
 12.17 HRAS KRAS PIK3CA
38
Phospholipase D signaling pathway 37
Show member pathways
 12.16 HRAS KIT KRAS PDGFRA PIK3CA
39
Axon guidance 37
12.15 HRAS KRAS PIK3CA
40
C-type lectin receptor signaling pathway 37
Show member pathways
 12.14 HRAS KRAS PIK3CA
41
GDNF-Family Ligands and Receptor Interactions 64
Show member pathways
 12.12 HRAS KRAS PIK3CA
42
Kit receptor signaling pathway 1
Show member pathways
 12.11 HRAS KIT PIK3CA
43
Cellular senescence (KEGG) 37
12.1 HRAS KRAS PIK3CA
44
mTOR Pathway 72
Show member pathways
 12.1 HRAS KRAS PIK3CA
45
Signaling by FGFR2 in disease 66
Show member pathways
 12.09 HRAS KRAS PIK3CA
46
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 12.09 HRAS KRAS PDGFRA PIK3CA
47
Longevity regulating pathway 37
Show member pathways
 12.07 HRAS KRAS PIK3CA
48
Signaling pathways regulating pluripotency of stem cells 37
12.02 HRAS KRAS PIK3CA
49
FoxO signaling pathway 37
Show member pathways
 12.02 HRAS KRAS PIK3CA
50
IL-2 Signaling Pathway 1
Show member pathways
 12 HRAS KRAS PIK3CA
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GO Terms for Lung Adenoid Cystic Carcinoma

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Cellular components related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.92 ALK DDR2 KIT PDGFRA

Biological processes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 ALK DDR2 KIT PDGFRA
2 phosphorylation GO:0016310 9.92 ALK DDR2 KIT PDGFRA PIK3CA
3 protein phosphorylation GO:0006468 9.91 ALK DDR2 KIT PDGFRA PIK3CA
4 positive regulation of gene expression GO:0010628 9.88 HRAS KIT KRAS NKX2-1
5 positive regulation of cell proliferation GO:0008284 9.83 DDR2 HRAS KIT KRAS PDGFRA
6 positive regulation of cell migration GO:0030335 9.81 HRAS KIT PDGFRA
7 positive regulation of protein phosphorylation GO:0001934 9.8 ALK HRAS KRAS
8 positive regulation of protein kinase B signaling GO:0051897 9.79 KIT PDGFRA PIK3CA
9 negative regulation of neuron apoptotic process GO:0043524 9.77 HRAS KRAS PIK3CA
10 positive regulation of MAPK cascade GO:0043410 9.77 HRAS KIT PDGFRA
11 MAPK cascade GO:0000165 9.76 HRAS KIT KRAS PDGFRA
12 animal organ morphogenesis GO:0009887 9.75 HRAS NKX2-1 PDGFRA
13 phosphatidylinositol phosphorylation GO:0046854 9.74 KIT PDGFRA PIK3CA
14 lung development GO:0030324 9.72 NFIB NKX2-1 PDGFRA
15 positive regulation of MAP kinase activity GO:0043406 9.67 HRAS KIT KRAS
16 peptidyl-tyrosine phosphorylation GO:0018108 9.67 ALK DDR2 KIT PDGFRA
17 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.63 KIT PDGFRA
18 regulation of long-term neuronal synaptic plasticity GO:0048169 9.62 HRAS KRAS
19 protein autophosphorylation GO:0046777 9.62 ALK DDR2 KIT PDGFRA
20 epithelial tube branching involved in lung morphogenesis GO:0060441 9.61 KRAS NKX2-1
21 Leydig cell differentiation GO:0033327 9.56 NKX2-1 PDGFRA
22 negative regulation of signal transduction GO:0009968 9.56 ALK DDR2 KIT PDGFRA
23 response to isolation stress GO:0035900 9.54 HRAS KRAS
24 type II pneumocyte differentiation GO:0060510 9.48 NFIB NKX2-1
25 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.46 ALK DDR2 KIT PDGFRA
26 Clara cell differentiation GO:0060486 9.4 NFIB NKX2-1
27 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.35 ALK DDR2 HRAS KIT PDGFRA
28 positive regulation of phospholipase C activity GO:0010863 8.8 HRAS KIT PDGFRA

Molecular functions related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.72 ALK DDR2 KIT PDGFRA PIK3CA
2 protein kinase activity GO:0004672 9.71 ALK DDR2 KIT PDGFRA
3 nucleotide binding GO:0000166 9.67 HRAS KIT KRAS PDGFRA
4 transmembrane signaling receptor activity GO:0004888 9.46 ALK DDR2 KIT PDGFRA
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 KIT PDGFRA PIK3CA
6 protein tyrosine kinase activity GO:0004713 9.26 ALK DDR2 KIT PDGFRA
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 ALK DDR2 KIT PDGFRA
Sources

Sources for Lung Adenoid Cystic Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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