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MCID: LNG011
MIFTS: 41

Lung Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Lung Adenoid Cystic Carcinoma

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MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Lung 12 74
Pulmonary Adenoid Cystic Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4872
NCIt 51 C5666
UMLS 74 C1334439
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Summaries for Lung Adenoid Cystic Carcinoma

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MalaCards based summary : Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to mucoepidermoid carcinoma and sarcoma, and has symptoms including dyspnea, hemoptysis and pain. An important gene associated with Lung Adenoid Cystic Carcinoma is MKI67 (Marker Of Proliferation Ki-67), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include lung, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Lung Adenoid Cystic Carcinoma

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Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 mucoepidermoid carcinoma 29.7 EGFR KRT7 MKI67
2 sarcoma 29.6 HRAS KIT KRAS PIK3CA
3 small cell carcinoma 29.4 EGFR KIT KRT7 NKX2-1 PDGFRA
4 squamous cell carcinoma 29.1 DDR2 EGFR HRAS MKI67 PIK3CA
5 adenoid cystic carcinoma 28.8 HRAS KIT KRAS KRT7 MKI67 NFIB
6 carney triad 10.4 KIT PDGFRA
7 pilocytic astrocytoma 10.4 KRAS SOX10
8 respiratory system benign neoplasm 10.4 KRAS NKX2-1
9 benign breast phyllodes tumor 10.3 KIT MKI67
10 reticular perineurioma 10.3 KIT PDGFRA
11 papillary hidradenoma 10.3 KIT PIK3CA
12 mast-cell leukemia 10.3 KIT PIK3CA
13 sm-ahnmd 10.3 KIT PDGFRA
14 well-differentiated liposarcoma 10.3 DDR2 KRT7
15 gastric leiomyosarcoma 10.3 KIT PDGFRA
16 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 NKX2-1
17 warthin tumor 10.3 KIT KRT7
18 pancreatic neuroendocrine tumor 10.3 MKI67 PIK3CA
19 malignant spindle cell melanoma 10.3 KIT SOX10
20 conventional fibrosarcoma 10.3 KIT PDGFRA
21 endometrial small cell carcinoma 10.3 KIT PDGFRA
22 desmoid tumor 10.3 KIT PDGFRA
23 solid adenocarcinoma with mucin production 10.2 KRT7 NKX2-1
24 ovarian germ cell teratoma 10.2 KRT7 NKX2-1
25 ceruminoma 10.2 KIT KRT7
26 hidrocystoma 10.2 KRT7 SOX10
27 hypereosinophilic syndrome, idiopathic 10.2 KIT PDGFRA
28 lung acinar adenocarcinoma 10.2 KRT7 NKX2-1
29 jejunal cancer 10.2 KIT KRT7
30 small cell carcinoma of the bladder 10.2 KRT7 NKX2-1
31 pulmonary vein stenosis 10.2 KIT MKI67 PDGFRA
32 ovarian germ cell cancer 10.2 KRT7 NKX2-1
33 rare adenocarcinoma of the breast 10.2 KRAS PIK3CA
34 rete testis adenocarcinoma 10.2 KIT NKX2-1
35 breast angiosarcoma 10.2 KIT SOX10
36 intratubular embryonal carcinoma 10.2 KIT KRT7
37 apocrine sweat gland neoplasm 10.2 KRT7 SOX10
38 papillary adenoma 10.2 KRT7 NKX2-1
39 neurilemmoma 10.2 KIT PDGFRA SOX10
40 neurofibroma 10.2 KIT PDGFRA SOX10
41 chromosome 14q11-q22 deletion syndrome 10.2 HRAS NKX2-1
42 thymoma, familial 10.2 HRAS KIT
43 spitz nevus 10.2 HRAS MKI67
44 cribriform carcinoma 10.2 KIT KRT7
45 squamous cell carcinoma of the oral tongue 10.2 MKI67 PIK3CA
46 bowen's disease 10.2 KRT7 MKI67
47 adenoid basal cell carcinoma 10.2 KIT KRT7
48 malignant conjunctival melanoma 10.2 HRAS SOX10
49 malignant leydig cell tumor 10.2 KIT KRT7
50 mesenchymal cell neoplasm 10.2 ALK KIT PDGFRA

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:



Diseases related to Lung Adenoid Cystic Carcinoma
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Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

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UMLS symptoms related to Lung Adenoid Cystic Carcinoma:


dyspnea, hemoptysis, pain, chest pain, wheezing, coughing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

27 (show all 46)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.91 EGFR PIK3CA HRAS KRAS
2 Decreased viability GR00106-A-0 10.91 KRAS
3 Decreased viability GR00173-A 10.91 PDGFRA
4 Decreased viability GR00221-A-1 10.91 ALK DDR2 EGFR PDGFRA PIK3CA HRAS
5 Decreased viability GR00221-A-2 10.91 DDR2 PIK3CA HRAS KRAS
6 Decreased viability GR00221-A-3 10.91 PDGFRA HRAS
7 Decreased viability GR00221-A-4 10.91 ALK DDR2 EGFR PDGFRA PIK3CA
8 Decreased viability GR00301-A 10.91 KRAS KIT
9 Decreased viability GR00381-A-1 10.91 KRAS
10 Decreased viability GR00402-S-2 10.91 ALK DDR2 EGFR PDGFRA PIK3CA HRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.2 SOX10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.2 KRAS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.2 SOX10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.2 PIK3CA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.2 KRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-129 10.2 PDGFRA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.2 PDGFRA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.2 PIK3CA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.2 PIK3CA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.2 PIK3CA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.2 KRAS
22 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.2 KRAS PIK3CA SOX10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.2 PIK3CA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.2 KRAS
25 Increased shRNA abundance (Z-score > 2) GR00366-A-207 10.2 PDGFRA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-22 10.2 KRAS
27 Increased shRNA abundance (Z-score > 2) GR00366-A-23 10.2 KRAS
28 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.2 PDGFRA SOX10
29 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.2 PIK3CA
30 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.2 KRAS PDGFRA PIK3CA SOX10
31 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.2 KRAS
32 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.2 KRAS
33 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.2 SOX10
34 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.2 SOX10
35 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.2 PDGFRA
36 Increased shRNA abundance (Z-score > 2) GR00366-A-77 10.2 PDGFRA
37 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.2 SOX10
38 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.2 SOX10
39 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.2 KRAS
40 Decreased viability in esophageal squamous lineage GR00235-A 9.96 DDR2 HRAS KIT KRAS KRT7 NFIB
41 Decreased cell migration GR00055-A-1 9.88 ALK DDR2 EGFR HRAS KRAS PIK3CA
42 Decreased substrate adherent cell growth GR00193-A-1 9.77 KIT
43 Decreased substrate adherent cell growth GR00193-A-2 9.77 ALK EGFR KIT
44 Decreased substrate adherent cell growth GR00193-A-4 9.77 KIT
45 Increased cell migration GR00055-A-3 9.55 DDR2 EGFR HRAS KRAS PIK3CA
46 Increased transferrin (TF) endocytosis GR00363-A 9.28 ALK DDR2 EGFR HRAS KIT NKX2-1

MGI Mouse Phenotypes related to Lung Adenoid Cystic Carcinoma:

47 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ALK DDR2 EGFR HRAS KIT KRAS
2 endocrine/exocrine gland MP:0005379 10.31 ALK DDR2 EGFR HRAS KIT KRAS
3 growth/size/body region MP:0005378 10.3 ALK DDR2 EGFR HRAS KIT KRAS
4 mortality/aging MP:0010768 10.25 ALK DDR2 EGFR HRAS KIT KRAS
5 cellular MP:0005384 10.24 DDR2 EGFR KIT KRAS KRT7 NKX2-1
6 cardiovascular system MP:0005385 10.2 DDR2 EGFR HRAS KIT KRAS NKX2-1
7 nervous system MP:0003631 10.2 ALK DDR2 EGFR HRAS KIT KRAS
8 integument MP:0010771 10.19 ALK DDR2 EGFR HRAS KIT KRAS
9 digestive/alimentary MP:0005381 10.18 EGFR HRAS KIT KRAS NFIB NKX2-1
10 neoplasm MP:0002006 10.18 ALK DDR2 EGFR HRAS KIT KRAS
11 craniofacial MP:0005382 10.13 DDR2 EGFR HRAS KIT KRAS NFIB
12 no phenotypic analysis MP:0003012 10.13 DDR2 EGFR HRAS KIT KRAS MKI67
13 normal MP:0002873 10.01 EGFR HRAS KIT KRAS MKI67 NKX2-1
14 limbs/digits/tail MP:0005371 10 DDR2 EGFR KIT KRAS PDGFRA SOX10
15 muscle MP:0005369 9.97 DDR2 EGFR KIT KRAS PDGFRA PIK3CA
16 reproductive system MP:0005389 9.86 ALK DDR2 EGFR KIT KRAS NKX2-1
17 pigmentation MP:0001186 9.85 ALK EGFR KIT KRAS PDGFRA SOX10
18 respiratory system MP:0005388 9.81 ALK EGFR HRAS KIT KRAS NFIB
19 renal/urinary system MP:0005367 9.8 EGFR HRAS KIT KRAS KRT7 PDGFRA
20 skeleton MP:0005390 9.61 ALK DDR2 EGFR HRAS KIT KRAS
21 vision/eye MP:0005391 9.17 ALK DDR2 EGFR KIT KRAS NFIB
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Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

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Search Clinical Trials , NIH Clinical Center for Lung Adenoid Cystic Carcinoma

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Genetic Tests for Lung Adenoid Cystic Carcinoma

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Anatomical Context for Lung Adenoid Cystic Carcinoma

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MalaCards organs/tissues related to Lung Adenoid Cystic Carcinoma:

42
Lung
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Publications for Lung Adenoid Cystic Carcinoma

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Articles related to Lung Adenoid Cystic Carcinoma:

# Title Authors Year
1
Primary Mediastinal Synovial Sarcoma with subsequent development of Primary Adenoid Cystic Carcinoma of Lung presenting as superior vena cava syndrome. ( 26992072 )
2016
2
A rare case of primary adenoid cystic carcinoma of lung. ( 25823114 )
2014
3
Primary adenoid cystic carcinoma of lung: a case report and review of the literature. ( 23771382 )
2013
4
Metastatic adenoid cystic carcinoma of lung: a case report. ( 17183870 )
2006
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Variations for Lung Adenoid Cystic Carcinoma

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Cosmic variations for Lung Adenoid Cystic Carcinoma:

9 (show top 50) (show all 548)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 0
2 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 0
3 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 0
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 0
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 0
6 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 0
7 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 0
8 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 0
9 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 0
10 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 0
11 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 0
12 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 0
13 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 0
14 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 0
15 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 0
16 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 0
17 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 0
18 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 0
19 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 0
20 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 0
21 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 0
22 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 0
23 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 0
24 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 0
25 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 0
26 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 0
27 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 0
28 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 0
29 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 0
30 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 0
31 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 0
32 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 0
33 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 0
34 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 0
35 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 0
36 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 0
37 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 0
38 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 0
39 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 0
40 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 0
41 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 0
42 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 0
43 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 0
44 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 0
45 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 0
46 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 0
47 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 0
48 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 0
49 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 0
50 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 0
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Expression for Lung Adenoid Cystic Carcinoma

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Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.
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Pathways for Lung Adenoid Cystic Carcinoma

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Pathways related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 65
Show member pathways
 13.8 ALK DDR2 EGFR HRAS KIT KRAS
2
GPCR Pathway 65
Show member pathways
 13.68 ALK DDR2 EGFR HRAS KIT KRAS
3
PEDF Induced Signaling 65
Show member pathways
 13.63 ALK DDR2 EGFR HRAS KIT KRAS
4
Activation of cAMP-Dependent PKA 65
Show member pathways
 13.51 ALK DDR2 EGFR HRAS KIT KRAS
5
TGF-Beta Pathway 65
Show member pathways
 13.48 ALK DDR2 EGFR HRAS KIT KRAS
6
Developmental Biology 67
Show member pathways
 13.46 EGFR HRAS KIT KRAS KRT7 PDGFRA
7
Class I MHC mediated antigen processing and presentation 67
Show member pathways
 13.41 EGFR HRAS KIT KRAS PDGFRA PIK3CA
8
Akt Signaling 65
Show member pathways
 13.37 ALK DDR2 EGFR HRAS KIT KRAS
9
Cytokine Signaling in Immune system 67
Show member pathways
 13.31 EGFR HRAS KIT KRAS PDGFRA PIK3CA
10
CREB Pathway 65
Show member pathways
 13.29 ALK DDR2 EGFR HRAS KIT KRAS
11
Nanog in Mammalian ESC Pluripotency 65
Show member pathways
 13.22 ALK DDR2 EGFR HRAS KIT KRAS
12
Phospholipase-C Pathway 65
Show member pathways
 13.03 EGFR HRAS KIT KRAS PDGFRA
13
Actin Nucleation by ARP-WASP Complex 65
Show member pathways
 12.97 ALK DDR2 EGFR HRAS KIT PDGFRA
14
PI3K-Akt signaling pathway 38
Show member pathways
 12.97 EGFR HRAS KIT KRAS PDGFRA PIK3CA
15
Human cytomegalovirus infection 38
Show member pathways
 12.93 EGFR HRAS KRAS PDGFRA PIK3CA
16
Development Angiotensin activation of ERK 23
Show member pathways
 12.91 EGFR HRAS KIT KRAS PDGFRA PIK3CA
17
Focal Adhesion 1 38
Show member pathways
 12.88 EGFR HRAS KRAS PDGFRA PIK3CA
18
p70S6K Signaling 65
Show member pathways
 12.88 ALK DDR2 EGFR HRAS KIT KRAS
19
NFAT and Cardiac Hypertrophy 65
Show member pathways
 12.84 EGFR HRAS KRAS PDGFRA PIK3CA
20
Endometrial cancer 38
Show member pathways
 12.79 EGFR HRAS KIT KRAS PDGFRA PIK3CA
21
MAPK signaling pathway 1 38
12.75 EGFR HRAS KIT KRAS PDGFRA
22
Gastric cancer 38
Show member pathways
 12.75 EGFR HRAS KIT KRAS PIK3CA
23
4-1BB Pathway 65
Show member pathways
 12.66 EGFR HRAS KRAS PDGFRA
24
Development Endothelin-1/EDNRA signaling 23
Show member pathways
 12.65 EGFR HRAS KRAS PIK3CA
25
Regulation of actin cytoskeleton 38 1
12.63 EGFR HRAS KRAS PDGFRA PIK3CA
26
Ras signaling pathway 38
Show member pathways
 12.61 EGFR HRAS KIT KRAS PDGFRA PIK3CA
27
Downstream signaling events of B Cell Receptor (BCR) 67
Show member pathways
 12.59 EGFR HRAS KIT KRAS PDGFRA PIK3CA
28
Immune response IL-23 signaling pathway 23
Show member pathways
 12.58 EGFR HRAS KRAS PDGFRA PIK3CA
29
Glioma 38
Show member pathways
 12.58 ALK EGFR HRAS KRAS PDGFRA PIK3CA
30
ErbB signaling pathway 1 38
Show member pathways
 12.57 EGFR HRAS KRAS PIK3CA
31
Pathways in cancer 38
12.53 ALK EGFR HRAS KIT KRAS PDGFRA
32
MicroRNAs in cancer 38
12.48 EGFR HRAS KRAS PDGFRA PIK3CA
33
mTOR signaling pathway (KEGG) 66
Show member pathways
 12.45 EGFR HRAS KRAS PDGFRA PIK3CA
34
VEGF Pathway (Qiagen) 65
Show member pathways
 12.4 EGFR HRAS KRAS PIK3CA
35
Apoptosis Pathway 73
Show member pathways
 12.36 EGFR HRAS KRAS PDGFRA PIK3CA
36
Human T-cell leukemia virus 1 infection 38
12.35 HRAS KRAS PDGFRA PIK3CA
37
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.35 EGFR HRAS KRAS PDGFRA PIK3CA
38
Development Ligand-independent activation of ESR1 and ESR2 23
Show member pathways
 12.32 EGFR HRAS PDGFRA PIK3CA
39
Signaling by ERBB2 67
Show member pathways
 12.29 EGFR HRAS KRAS PIK3CA
40
Proteoglycans in cancer 38
12.29 EGFR HRAS KRAS PIK3CA
41
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.24 EGFR KIT KRAS PDGFRA
42
Kit receptor signaling pathway 1
Show member pathways
 12.16 HRAS KIT PIK3CA
43
Cellular senescence (KEGG) 38
12.15 HRAS KRAS PIK3CA
44
mTOR Pathway 73
Show member pathways
 12.15 HRAS KRAS PIK3CA
45
Signaling by FGFR2 in disease 67
Show member pathways
 12.14 HRAS KRAS PIK3CA
46
MAPK Signaling: Mitogen Stimulation Pathway 66
Show member pathways
 12.13 EGFR HRAS KRAS PDGFRA PIK3CA
47
Longevity regulating pathway 38
Show member pathways
 12.12 HRAS KRAS PIK3CA
48
Transcription Androgen Receptor nuclear signaling 23
Show member pathways
 12.1 EGFR HRAS PIK3CA
49
FoxO signaling pathway 38
Show member pathways
 12.1 EGFR HRAS KRAS PIK3CA
50
Signaling pathways regulating pluripotency of stem cells 38
12.07 HRAS KRAS PIK3CA
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GO Terms for Lung Adenoid Cystic Carcinoma

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Cellular components related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.02 ALK DDR2 EGFR KIT PDGFRA

Biological processes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.99 ALK DDR2 EGFR KIT PDGFRA PIK3CA
2 positive regulation of gene expression GO:0010628 9.96 HRAS KIT KRAS NKX2-1 SOX10
3 cell proliferation GO:0008283 9.95 ALK EGFR HRAS MKI67
4 positive regulation of cell proliferation GO:0008284 9.93 DDR2 EGFR HRAS KIT KRAS PDGFRA
5 positive regulation of cell migration GO:0030335 9.91 EGFR HRAS KIT PDGFRA
6 positive regulation of protein kinase B signaling GO:0051897 9.85 EGFR KIT PDGFRA PIK3CA
7 negative regulation of neuron apoptotic process GO:0043524 9.83 HRAS KRAS PIK3CA
8 animal organ morphogenesis GO:0009887 9.82 HRAS NKX2-1 PDGFRA
9 phosphatidylinositol phosphorylation GO:0046854 9.8 EGFR KIT PDGFRA PIK3CA
10 MAPK cascade GO:0000165 9.8 EGFR HRAS KIT KRAS PDGFRA
11 liver development GO:0001889 9.79 EGFR KRAS PIK3CA
12 cell differentiation GO:0030154 9.77 DDR2 EGFR SOX10
13 positive regulation of fibroblast proliferation GO:0048146 9.76 DDR2 EGFR PDGFRA
14 positive regulation of protein phosphorylation GO:0001934 9.74 EGFR HRAS KRAS
15 lung development GO:0030324 9.73 EGFR NFIB NKX2-1 PDGFRA
16 positive regulation of MAPK cascade GO:0043410 9.7 HRAS KIT PDGFRA
17 regulation of long-term neuronal synaptic plasticity GO:0048169 9.66 HRAS KRAS
18 melanocyte differentiation GO:0030318 9.65 KIT SOX10
19 epithelial tube branching involved in lung morphogenesis GO:0060441 9.65 KRAS NKX2-1
20 peptidyl-tyrosine phosphorylation GO:0018108 9.65 ALK DDR2 EGFR KIT PDGFRA
21 digestive tract morphogenesis GO:0048546 9.64 EGFR SOX10
22 tongue development GO:0043586 9.63 EGFR KIT
23 cerebral cortex cell migration GO:0021795 9.63 EGFR NKX2-1
24 Leydig cell differentiation GO:0033327 9.62 NKX2-1 PDGFRA
25 positive regulation of MAP kinase activity GO:0043406 9.62 EGFR HRAS KIT KRAS
26 response to isolation stress GO:0035900 9.61 HRAS KRAS
27 type II pneumocyte differentiation GO:0060510 9.59 NFIB NKX2-1
28 Clara cell differentiation GO:0060486 9.58 NFIB NKX2-1
29 protein autophosphorylation GO:0046777 9.55 ALK DDR2 EGFR KIT PDGFRA
30 positive regulation of phospholipase C activity GO:0010863 9.54 HRAS KIT PDGFRA
31 negative regulation of apoptotic process GO:0043066 9.48 EGFR SOX10
32 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.26 EGFR HRAS KIT PDGFRA
33 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.02 ALK DDR2 EGFR KIT PDGFRA
34 phosphorylation GO:0016310 10.01 ALK DDR2 EGFR KIT PDGFRA PIK3CA

Molecular functions related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.95 ALK DDR2 EGFR KIT MKI67 PDGFRA
2 protein kinase activity GO:0004672 9.83 ALK DDR2 EGFR KIT PDGFRA
3 kinase activity GO:0016301 9.8 ALK DDR2 EGFR KIT PDGFRA PIK3CA
4 nucleotide binding GO:0000166 9.77 EGFR HRAS KIT KRAS PDGFRA
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.63 EGFR KIT PDGFRA
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.46 EGFR KIT PDGFRA PIK3CA
7 protein tyrosine kinase activity GO:0004713 9.35 ALK DDR2 EGFR KIT PDGFRA
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 ALK DDR2 EGFR KIT PDGFRA
9 transmembrane signaling receptor activity GO:0004888 8.96 EGFR
10 protein binding GO:0005515 10.26 ALK DDR2 EGFR HRAS KIT KRAS
Sources

Sources for Lung Adenoid Cystic Carcinoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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