Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: LNG011
MIFTS: 45

Lung Adenoid Cystic Carcinoma

Categories: Cancer diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
Sources

Aliases & Classifications for Lung Adenoid Cystic Carcinoma

About this section

MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Lung 12 72
Pulmonary Adenoid Cystic Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4872
NCIt 50 C5666
UMLS 72 C1334439
Sources

Summaries for Lung Adenoid Cystic Carcinoma

About this section
MalaCards based summary : Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to small cell carcinoma and adenoid cystic carcinoma, and has symptoms including dyspnea, chest pain and hemoptysis. An important gene associated with Lung Adenoid Cystic Carcinoma is ACCS (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive)), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include lung and tongue, and related phenotypes are Decreased viability and Decreased viability

Sources

Related Diseases for Lung Adenoid Cystic Carcinoma

About this section

Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 28.9 PDGFRA NKX2-1 KRT7 KIT EGFR
2 adenoid cystic carcinoma 27.9 SOX10 PIK3CA NFIB MYB KRT7 KRAS
3 adenocarcinoma 27.6 PIK3CA KRAS KIT HRAS EGFR ALK
4 lung cancer susceptibility 3 26.7 PIK3CA NKX2-1 KRT7 KRAS HRAS EGFR
5 reticular perineurioma 10.6 PDGFRA KIT
6 sm-ahnmd 10.5 PDGFRA KIT
7 gastric leiomyosarcoma 10.5 PDGFRA KIT
8 malignant spindle cell melanoma 10.5 SOX10 KIT
9 desmoid tumor 10.5 PDGFRA KIT
10 endometrial small cell carcinoma 10.5 PDGFRA KIT
11 breast adenoid cystic carcinoma 10.5 NFIB KIT
12 conventional fibrosarcoma 10.5 PDGFRA KIT
13 ceruminoma 10.4 KRT7 KIT
14 jejunal cancer 10.4 KRT7 KIT
15 polymorphous low-grade adenocarcinoma 10.4 NFIB MYB KIT
16 pulmonary vein stenosis 10.4 PDGFRA KIT
17 breast angiosarcoma 10.4 SOX10 KIT
18 intratubular embryonal carcinoma 10.4 KRT7 KIT
19 cribriform carcinoma 10.4 KRT7 KIT
20 hypereosinophilic syndrome, idiopathic 10.4 PDGFRA KIT
21 cutaneous adenocystic carcinoma 10.3 NFIB KRT7
22 hidrocystoma 10.3 SOX10 KRT7
23 thymoma, familial 10.3 KIT HRAS
24 ovarian germ cell teratoma 10.3 NKX2-1 KRT7
25 solid adenocarcinoma with mucin production 10.3 NKX2-1 KRT7
26 small cell carcinoma of the bladder 10.3 NKX2-1 KRT7
27 lung acinar adenocarcinoma 10.3 NKX2-1 KRT7
28 adenoid basal cell carcinoma 10.3 KRT7 KIT
29 rete testis adenocarcinoma 10.3 NKX2-1 KIT
30 ovarian germ cell cancer 10.3 NKX2-1 KRT7
31 apocrine sweat gland neoplasm 10.3 SOX10 KRT7
32 prostate small cell carcinoma 10.3 NKX2-1 KIT
33 neurofibroma 10.3 SOX10 PDGFRA KIT
34 neurilemmoma 10.3 SOX10 PDGFRA KIT
35 malignant leydig cell tumor 10.3 KRT7 KIT
36 papillary adenoma 10.3 NKX2-1 KRT7
37 ovarian melanoma 10.3 KIT HRAS
38 chromosome 14q11-q22 deletion syndrome 10.3 NKX2-1 HRAS
39 rare adenocarcinoma of the breast 10.3 PIK3CA KRAS
40 mesenchymal cell neoplasm 10.2 PDGFRA KIT ALK
41 malignant conjunctival melanoma 10.2 SOX10 HRAS
42 malignant spiradenoma 10.2 PIK3CA KRT7
43 sigmoid neoplasm 10.2 KRAS HRAS
44 duodenum adenocarcinoma 10.2 KRT7 KRAS
45 papillary serous adenocarcinoma 10.2 NKX2-1 KRT7
46 periampullary adenoma 10.1 KRAS HRAS
47 merkel cell carcinoma 10.1 NKX2-1 KRT7 KIT
48 schimmelpenning-feuerstein-mims syndrome 10.1 KRAS HRAS
49 thymus cancer 10.1 NKX2-1 KRT7 KIT
50 teratoma 10.1 NKX2-1 KRT7 KIT

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:



Diseases related to Lung Adenoid Cystic Carcinoma
Sources

Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

About this section

UMLS symptoms related to Lung Adenoid Cystic Carcinoma:


dyspnea, chest pain, hemoptysis, pain, wheezing, coughing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.85 EGFR PIK3CA HRAS KRAS
2 Decreased viability GR00106-A-0 10.85 KRAS
3 Decreased viability GR00173-A 10.85 PDGFRA
4 Decreased viability GR00221-A-1 10.85 ALK DDR2 EGFR PDGFRA PIK3CA HRAS
5 Decreased viability GR00221-A-2 10.85 DDR2 PIK3CA HRAS KRAS
6 Decreased viability GR00221-A-3 10.85 PDGFRA HRAS
7 Decreased viability GR00221-A-4 10.85 ALK DDR2 EGFR PDGFRA PIK3CA
8 Decreased viability GR00301-A 10.85 KRAS KIT
9 Decreased viability GR00381-A-1 10.85 KRAS
10 Decreased viability GR00402-S-2 10.85 ALK DDR2 EGFR PDGFRA PIK3CA HRAS
11 Decreased viability in esophageal squamous lineage GR00235-A 9.93 ACCS DDR2 HRAS KIT KRAS KRT7
12 Decreased cell migration GR00055-A-1 9.8 ALK DDR2 EGFR HRAS KRAS PIK3CA
13 Increased cell migration GR00055-A-3 9.35 DDR2 EGFR HRAS KRAS PIK3CA
14 Increased transferrin (TF) endocytosis GR00363-A 9.32 ACCS ALK DDR2 EGFR HRAS KIT

MGI Mouse Phenotypes related to Lung Adenoid Cystic Carcinoma:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.34 ALK DDR2 EGFR HRAS KIT KRAS
2 growth/size/body region MP:0005378 10.33 ALK DDR2 EGFR HRAS KIT KRAS
3 homeostasis/metabolism MP:0005376 10.31 ALK DDR2 EGFR HRAS KIT KRAS
4 cellular MP:0005384 10.29 DDR2 EGFR KIT KRAS KRT7 MYB
5 mortality/aging MP:0010768 10.27 ALK DDR2 EGFR HRAS KIT KRAS
6 cardiovascular system MP:0005385 10.25 DDR2 EGFR HRAS KIT KRAS MYB
7 integument MP:0010771 10.22 ALK DDR2 EGFR HRAS KIT KRAS
8 nervous system MP:0003631 10.2 ALK DDR2 EGFR HRAS KIT KRAS
9 digestive/alimentary MP:0005381 10.18 EGFR HRAS KIT KRAS NFIB NKX2-1
10 neoplasm MP:0002006 10.18 ALK DDR2 EGFR HRAS KIT KRAS
11 craniofacial MP:0005382 10.13 DDR2 EGFR HRAS KIT KRAS NFIB
12 no phenotypic analysis MP:0003012 10.13 DDR2 EGFR HRAS KIT KRAS MYB
13 embryo MP:0005380 10.11 EGFR KIT KRAS MYB PDGFRA PIK3CA
14 normal MP:0002873 10.01 EGFR HRAS KIT KRAS MYB NKX2-1
15 limbs/digits/tail MP:0005371 9.99 DDR2 EGFR KIT KRAS PDGFRA SOX10
16 reproductive system MP:0005389 9.86 ALK DDR2 EGFR KIT KRAS NKX2-1
17 pigmentation MP:0001186 9.85 ALK EGFR KIT KRAS PDGFRA SOX10
18 respiratory system MP:0005388 9.81 ALK EGFR HRAS KIT KRAS NFIB
19 renal/urinary system MP:0005367 9.8 EGFR HRAS KIT KRAS KRT7 PDGFRA
20 skeleton MP:0005390 9.61 ALK DDR2 EGFR HRAS KIT KRAS
21 vision/eye MP:0005391 9.17 ALK DDR2 EGFR KIT KRAS NFIB
Sources

Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

About this section

Search Clinical Trials , NIH Clinical Center for Lung Adenoid Cystic Carcinoma

Sources

Genetic Tests for Lung Adenoid Cystic Carcinoma

About this section
Sources

Anatomical Context for Lung Adenoid Cystic Carcinoma

About this section

MalaCards organs/tissues related to Lung Adenoid Cystic Carcinoma:

41
Lung, Tongue
Sources

Publications for Lung Adenoid Cystic Carcinoma

About this section

Articles related to Lung Adenoid Cystic Carcinoma:

(show all 11)
# Title Authors PMID Year
1
Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection. 38
31067606 2019
2
[The clinicopathological features and curative effect of the bronchoscopic interventional therapy combined with radiotherapy for the treatment of locally recurrent lung adenoid cystic carcinoma]. 38
30481940 2018
3
Primary mediastinal synovial sarcoma with subsequent development of primary adenoid cystic carcinoma of lung presenting as superior vena cava syndrome. 38
26992072 2018
4
[Four Cases Report on Primary Lung Adenoid Cystic Carcinoma]. 38
29167011 2017
5
Metachronous adenoid cystic carcinoma in the peripheral lung and at base of the tongue. 38
25177443 2014
6
A rare case of primary adenoid cystic carcinoma of lung. 38
25823114 2014
7
Primary adenoid cystic carcinoma of lung: a case report and review of the literature. 38
23771382 2013
8
[Recurrent adenoid cystic carcinoma. Review based on a case report]. 38
19145392 2009
9
Unusual lung mass: benign or malignant? 38
19035058 2008
10
Metastatic adenoid cystic carcinoma of lung: a case report. 38
17183870 2006
11
[Bilateral renal metastases of lung adenoid cystic carcinoma]. 38
1661561 1991
Sources

Variations for Lung Adenoid Cystic Carcinoma

About this section

Cosmic variations for Lung Adenoid Cystic Carcinoma:

9 (show top 50) (show all 548)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 9
2 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 9
3 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 9
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 9
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 9
6 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 9
7 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 9
8 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 9
9 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 9
10 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 9
11 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 9
12 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 9
13 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 9
14 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 9
15 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 9
16 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 9
17 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 9
18 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 9
19 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 9
20 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 9
21 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 9
22 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 9
23 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 9
24 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 9
25 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 9
26 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 9
27 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 9
28 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 9
29 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 9
30 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 9
31 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 9
32 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 9
33 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 9
34 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 9
35 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 9
36 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 9
37 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 9
38 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 9
39 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 9
40 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 9
41 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 9
42 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 9
43 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 9
44 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 9
45 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 9
46 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 9
47 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 9
48 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 9
49 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 9
50 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 9
Sources

Expression for Lung Adenoid Cystic Carcinoma

About this section
Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.
Sources

Pathways for Lung Adenoid Cystic Carcinoma

About this section

Pathways related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.82 SOX10 PDGFRA KRAS KIT HRAS EGFR
2
PEDF Induced Signaling 64
Show member pathways
 13.65 PDGFRA KRAS KIT HRAS EGFR DDR2
3
Activation of cAMP-Dependent PKA 64
Show member pathways
 13.52 PDGFRA KRAS KIT HRAS EGFR DDR2
4
TGF-Beta Pathway 64
Show member pathways
 13.51 PIK3CA PDGFRA KRAS KIT HRAS EGFR
5
Developmental Biology 66
Show member pathways
 13.47 PIK3CA PDGFRA KRT7 KRAS KIT HRAS
6
Akt Signaling 64
Show member pathways
 13.38 PDGFRA KRAS KIT HRAS EGFR DDR2
7
Cytokine Signaling in Immune system 66
Show member pathways
 13.32 PIK3CA PDGFRA KRAS KIT HRAS EGFR
8
CREB Pathway 64
Show member pathways
 13.31 PDGFRA KRAS KIT HRAS EGFR DDR2
9
Nanog in Mammalian ESC Pluripotency 64
Show member pathways
 13.26 PDGFRA KRAS KIT HRAS EGFR DDR2
10
Phospholipase-C Pathway 64
Show member pathways
 13.03 PDGFRA KRAS KIT HRAS EGFR
11
Actin Nucleation by ARP-WASP Complex 64
Show member pathways
 12.99 PDGFRA KIT HRAS EGFR DDR2 ALK
12
Human cytomegalovirus infection 37
Show member pathways
 12.94 PIK3CA PDGFRA KRAS HRAS EGFR
13
Development Angiotensin activation of ERK 22
Show member pathways
 12.92 PIK3CA PDGFRA KRAS KIT HRAS EGFR
14
p70S6K Signaling 64
Show member pathways
 12.92 PDGFRA KRAS KIT HRAS EGFR DDR2
15
Focal Adhesion 37 1
Show member pathways
 12.88 PIK3CA PDGFRA KRAS HRAS EGFR
16
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.85 PIK3CA PDGFRA KRAS HRAS EGFR
17
Endometrial cancer 37
Show member pathways
 12.82 PIK3CA PDGFRA KRAS KIT HRAS EGFR
18
PI3K-Akt signaling pathway 37
Show member pathways
 12.81 PIK3CA PDGFRA MYB KRAS KIT HRAS
19
MAPK signaling pathway 37 1
12.76 PDGFRA KRAS KIT HRAS EGFR
20
Gastric cancer 37
Show member pathways
 12.75 PIK3CA KRAS KIT HRAS EGFR
21
4-1BB Pathway 64
Show member pathways
 12.66 PDGFRA KRAS HRAS EGFR
22
Development Endothelin-1/EDNRA signaling 22
Show member pathways
 12.65 PIK3CA KRAS HRAS EGFR
23
Ras signaling pathway 37
Show member pathways
 12.65 PIK3CA PDGFRA KRAS KIT HRAS EGFR
24
Regulation of actin cytoskeleton 37 1
12.63 PIK3CA PDGFRA KRAS HRAS EGFR
25
Downstream signaling events of B Cell Receptor (BCR) 66
Show member pathways
 12.63 PIK3CA PDGFRA KRAS KIT HRAS EGFR
26
Glioma 37
Show member pathways
 12.62 PIK3CA PDGFRA KRAS HRAS EGFR ALK
27
Immune response IL-23 signaling pathway 22
Show member pathways
 12.59 PIK3CA PDGFRA KRAS HRAS EGFR
28
ErbB signaling pathway 37 1
Show member pathways
 12.57 PIK3CA KRAS HRAS EGFR
29
MicroRNAs in cancer 37
12.52 PIK3CA PDGFRA KRAS HRAS EGFR
30
Pathways in cancer 37
12.52 PIK3CA PDGFRA KRAS KIT HRAS EGFR
31
mTOR signaling pathway (KEGG) 37
Show member pathways
 12.47 PIK3CA PDGFRA KRAS HRAS EGFR
32
VEGF Pathway (Qiagen) 64
Show member pathways
 12.4 PIK3CA KRAS HRAS EGFR
33
Apoptosis Pathway 71
Show member pathways
 12.4 PIK3CA PDGFRA KRAS HRAS EGFR
34
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.39 PIK3CA PDGFRA KRAS HRAS EGFR
35
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.33 PIK3CA PDGFRA HRAS EGFR
36
Proteoglycans in cancer 37
12.31 PIK3CA KRAS HRAS EGFR
37
Human T-cell leukemia virus 1 infection 37
12.31 PIK3CA PDGFRA MYB KRAS HRAS
38
Signaling by ERBB2 66
Show member pathways
 12.3 PIK3CA KRAS HRAS EGFR
39
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.24 PDGFRA KRAS KIT EGFR
40
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 12.17 PIK3CA PDGFRA KRAS HRAS EGFR
41
Transcription Androgen Receptor nuclear signaling 22
Show member pathways
 12.1 PIK3CA HRAS EGFR
42
FoxO signaling pathway 37
Show member pathways
 12.1 PIK3CA KRAS HRAS EGFR
43
Signaling pathways regulating pluripotency of stem cells 37
12.08 PIK3CA KRAS HRAS
44
Autophagy - animal 37
12.06 PIK3CA KRAS HRAS
45
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.06 PIK3CA KRAS HRAS EGFR
46
IL-2 Signaling Pathway 1
Show member pathways
 12.05 PIK3CA KRAS HRAS
47
Signaling by PTK6 66
Show member pathways
 12.04 KRAS HRAS EGFR
48
UVA-Induced MAPK Signaling 64
Show member pathways
 12.03 KRAS HRAS EGFR
49
Phospholipase D signaling pathway 37
Show member pathways
 12.02 PIK3CA PDGFRA KRAS KIT HRAS EGFR
50
AKT Signaling Pathway 67
12.01 PIK3CA PDGFRA KRAS HRAS EGFR
Sources

GO Terms for Lung Adenoid Cystic Carcinoma

About this section

Cellular components related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.02 PDGFRA KIT EGFR DDR2 ALK

Biological processes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.99 PIK3CA PDGFRA KIT EGFR DDR2 ALK
2 positive regulation of gene expression GO:0010628 9.97 SOX10 NKX2-1 KRAS KIT HRAS
3 positive regulation of cell proliferation GO:0008284 9.93 PDGFRA KRAS KIT HRAS EGFR DDR2
4 positive regulation of cell migration GO:0030335 9.9 PDGFRA KIT HRAS EGFR
5 positive regulation of protein kinase B signaling GO:0051897 9.85 PIK3CA PDGFRA KIT EGFR
6 negative regulation of neuron apoptotic process GO:0043524 9.83 PIK3CA KRAS HRAS
7 animal organ morphogenesis GO:0009887 9.82 PDGFRA NKX2-1 HRAS
8 MAPK cascade GO:0000165 9.8 PDGFRA KRAS KIT HRAS EGFR
9 liver development GO:0001889 9.79 PIK3CA KRAS EGFR
10 cell differentiation GO:0030154 9.78 SOX10 EGFR DDR2
11 positive regulation of fibroblast proliferation GO:0048146 9.76 PDGFRA EGFR DDR2
12 positive regulation of protein phosphorylation GO:0001934 9.75 KRAS HRAS EGFR
13 lung development GO:0030324 9.73 PDGFRA NKX2-1 NFIB EGFR
14 positive regulation of MAPK cascade GO:0043410 9.7 PDGFRA KIT HRAS
15 regulation of long-term neuronal synaptic plasticity GO:0048169 9.66 KRAS HRAS
16 melanocyte differentiation GO:0030318 9.65 SOX10 KIT
17 epithelial tube branching involved in lung morphogenesis GO:0060441 9.65 NKX2-1 KRAS
18 peptidyl-tyrosine phosphorylation GO:0018108 9.65 PDGFRA KIT EGFR DDR2 ALK
19 digestive tract morphogenesis GO:0048546 9.64 SOX10 EGFR
20 tongue development GO:0043586 9.64 KIT EGFR
21 Leydig cell differentiation GO:0033327 9.63 PDGFRA NKX2-1
22 cerebral cortex cell migration GO:0021795 9.63 NKX2-1 EGFR
23 positive regulation of MAP kinase activity GO:0043406 9.62 KRAS KIT HRAS EGFR
24 response to isolation stress GO:0035900 9.61 KRAS HRAS
25 type II pneumocyte differentiation GO:0060510 9.59 NKX2-1 NFIB
26 Clara cell differentiation GO:0060486 9.56 NKX2-1 NFIB
27 protein autophosphorylation GO:0046777 9.55 PDGFRA KIT EGFR DDR2 ALK
28 positive regulation of phospholipase C activity GO:0010863 9.54 PDGFRA KIT HRAS
29 negative regulation of apoptotic process GO:0043066 9.48 SOX10 EGFR
30 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.26 PDGFRA KIT HRAS EGFR
31 phosphatidylinositol phosphorylation GO:0046854 9.19 PIK3CA
32 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.02 PDGFRA KIT EGFR DDR2 ALK
33 positive regulation of transcription by RNA polymerase II GO:0045944 10.1 SOX10 NKX2-1 NFIB MYB HRAS EGFR
34 phosphorylation GO:0016310 10.01 PIK3CA PDGFRA KIT EGFR DDR2 ALK

Molecular functions related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.8 PDGFRA KIT EGFR DDR2 ALK
2 kinase activity GO:0016301 9.8 PIK3CA PDGFRA KIT EGFR DDR2 ALK
3 nucleotide binding GO:0000166 9.77 PDGFRA KRAS KIT HRAS EGFR
4 protein tyrosine kinase activity GO:0004713 9.35 PDGFRA KIT EGFR DDR2 ALK
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 PDGFRA KIT EGFR DDR2 ALK
6 transmembrane signaling receptor activity GO:0004888 8.96 EGFR
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.85 PIK3CA
8 protein binding GO:0005515 10.25 SOX10 PIK3CA PDGFRA NKX2-1 MYB KRT7
Sources

Sources for Lung Adenoid Cystic Carcinoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....