Lung Adenoid Cystic Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LNG011 MIFTS: 40	Lung Adenoid Cystic Carcinoma Categories: Cancer diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Download Expand all tables

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Aliases & Classifications for Lung Adenoid Cystic Carcinoma

MalaCards integrated aliases for Lung Adenoid Cystic Carcinoma:

Name: Lung Adenoid Cystic Carcinoma ¹² ¹⁵

Adenoid Cystic Carcinoma of Lung ¹² ⁷³

Pulmonary Adenoid Cystic Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4872

NCIt ⁵⁰ C5666

UMLS ⁷³ C1334439

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Summaries for Lung Adenoid Cystic Carcinoma

MalaCards based summary : Lung Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of lung, is related to sarcoma and adenoid cystic carcinoma, and has symptoms including chest pain, coughing and dyspnea. An important gene associated with Lung Adenoid Cystic Carcinoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are GPCR Pathway and HIV Life Cycle. Affiliated tissues include lung, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Lung Adenoid Cystic Carcinoma

Diseases related to Lung Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)

#	Related Disease	Score	Top Affiliating Genes
1	sarcoma	28.8	HRAS KIT KRAS PIK3CA
2	adenoid cystic carcinoma	27.9	FBXW7 HRAS KIT KRAS NFIB PIK3CA
3	squamous cell carcinoma	27.6	DDR2 EGFR HRAS KRAS PIK3CA
4	rare adenocarcinoma of the breast	10.6	KRAS PIK3CA
5	reticular perineurioma	10.5	KIT PDGFRA
6	sm-ahnmd	10.5	KIT PDGFRA
7	gastric leiomyosarcoma	10.5	KIT PDGFRA
8	desmoid tumor	10.5	KIT PDGFRA
9	sarcomatoid renal cell carcinoma	10.5	KIT PDGFRA
10	conventional fibrosarcoma	10.5	KIT PDGFRA
11	rete testis adenocarcinoma	10.5	KIT NKX2-1
12	clear cell adenofibroma	10.5	PDGFRA PIK3CA
13	endometrial small cell carcinoma	10.4	KIT PDGFRA
14	pulmonary vein stenosis	10.4	KIT PDGFRA
15	hypereosinophilic syndrome, idiopathic	10.4	KIT PDGFRA
16	prostate adenoid cystic carcinoma	10.4	HRAS PIK3CA
17	kyasanur forest disease	10.4	ALK KRAS
18	papillary hidradenoma	10.4	KIT PIK3CA
19	lung papillary adenocarcinoma	10.4	ALK EML4
20	chromosome 14q11-q22 deletion syndrome	10.4	HRAS NKX2-1
21	respiratory system benign neoplasm	10.4	KRAS NKX2-1
22	bladder adenocarcinoma	10.3	FBXW7 HRAS
23	carney triad	10.3	KIT PDGFRA
24	malignant struma ovarii	10.3	HRAS NKX2-1
25	heart sarcoma	10.3	KIT PDGFRA
26	thymoma, familial	10.2	HRAS KIT
27	ovarian melanoma	10.2	HRAS KIT
28	chronic eosinophilic leukemia	10.2	KIT PDGFRA
29	sigmoid neoplasm	10.2	HRAS KRAS
30	mesenchymal cell neoplasm	10.1	ALK KIT PDGFRA
31	serous cystadenocarcinoma	10.1	FBXW7 HRAS PIK3CA
32	rosai-dorfman disease	10.1	KRAS PDGFRA
33	cystadenocarcinoma	10.1	FBXW7 HRAS PIK3CA
34	schimmelpenning-feuerstein-mims syndrome	10.1	HRAS KRAS
35	periampullary adenoma	10.1	HRAS KRAS
36	ovarian serous cystadenocarcinoma	10.1	FBXW7 HRAS PIK3CA
37	rete testis neoplasm	10.1	KIT NKX2-1
38	bile duct cysts	10.1	HRAS KRAS
39	breast squamous cell carcinoma	10.1	EGFR PIK3CA
40	secondary hypertrophic osteoarthropathy	10.1	HRAS KRAS
41	adenoiditis	10.0
42	nasal cavity adenocarcinoma	10.0	HRAS KRAS
43	thyroid cancer, nonmedullary, 2	10.0	HRAS NKX2-1 PIK3CA
44	anal canal adenocarcinoma	10.0	HRAS KRAS
45	ovary serous adenocarcinoma	10.0	HRAS KRAS
46	cervical adenosquamous carcinoma	10.0	EGFR PDGFRA
47	ampulla of vater neoplasm	9.9	HRAS KRAS
48	ovarian cystadenocarcinoma	9.9	HRAS KRAS
49	sarcoma, synovial	9.9
50	mediastinitis	9.9

Graphical network of the top 20 diseases related to Lung Adenoid Cystic Carcinoma:

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Symptoms & Phenotypes for Lung Adenoid Cystic Carcinoma

UMLS symptoms related to Lung Adenoid Cystic Carcinoma:

chest pain, coughing, dyspnea, hemoptysis, pain, wheezing

GenomeRNAi Phenotypes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

²⁶ (show all 37)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	11.02	HRAS EGFR KRAS PIK3CA
2	Decreased viability	GR00106-A-0	11.02	KRAS
3	Decreased viability	GR00173-A	11.02	PDGFRA
4	Decreased viability	GR00221-A-1	11.02	DDR2 HRAS EGFR ALK KIT KRAS
5	Decreased viability	GR00221-A-2	11.02	DDR2 HRAS KRAS PIK3CA
6	Decreased viability	GR00221-A-3	11.02	HRAS PDGFRA
7	Decreased viability	GR00221-A-4	11.02	DDR2 EGFR ALK PIK3CA PDGFRA
8	Decreased viability	GR00301-A	11.02	KRAS KIT
9	Decreased viability	GR00381-A-1	11.02	KRAS
10	Decreased viability	GR00402-S-2	11.02	DDR2 HRAS EGFR ALK KIT KRAS
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	10.05	KIT
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	10.05	PIK3CA
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	10.05	FBXW7
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	10.05	FBXW7
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	10.05	FBXW7 KIT
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	10.05	FBXW7 KIT PIK3CA
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.05	PIK3CA
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	10.05	PIK3CA
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-170	10.05	KIT
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	10.05	FBXW7 PIK3CA
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	10.05	FBXW7
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	10.05	PIK3CA
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	10.05	KIT
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.05	KIT PIK3CA
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	10.05	FBXW7
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	10.05	PIK3CA
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.05	FBXW7
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.05	KIT
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	10.05	KIT
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	10.05	KIT
31	Decreased cell migration	GR00055-A-1	9.88	HRAS EGFR ALK DDR2 KRAS PIK3CA
32	Decreased viability in esophageal squamous lineage	GR00235-A	9.86	DDR2 KIT KRAS NFIB NKX2-1 HRAS
33	Decreased substrate adherent cell growth	GR00193-A-1	9.77	KIT
34	Decreased substrate adherent cell growth	GR00193-A-2	9.77	ALK EGFR KIT
35	Decreased substrate adherent cell growth	GR00193-A-4	9.77	KIT
36	Increased cell migration	GR00055-A-3	9.55	EGFR DDR2 HRAS KRAS PIK3CA
37	Increased transferrin (TF) endocytosis	GR00363-A	9.28	DDR2 ALK EGFR FBXW7 KIT HRAS

MGI Mouse Phenotypes related to Lung Adenoid Cystic Carcinoma:

⁴⁶ (show all 20)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	10.3	FBXW7 EGFR ALK DDR2 KRAS KIT
2	growth/size/body region	MP:0005378	10.29	DDR2 FBXW7 ALK EGFR HRAS KRAS
3	homeostasis/metabolism	MP:0005376	10.28	DDR2 ALK EGFR HRAS KRAS FBXW7
4	cardiovascular system	MP:0005385	10.24	DDR2 EGFR HRAS KRAS FBXW7 KIT
5	mortality/aging	MP:0010768	10.24	DDR2 ALK EGFR HRAS KRAS FBXW7
6	cellular	MP:0005384	10.19	EGFR DDR2 FBXW7 KIT PDGFRA NKX2-1
7	craniofacial	MP:0005382	10.18	FBXW7 EGFR DDR2 KRAS KIT HRAS
8	integument	MP:0010771	10.18	FBXW7 ALK EGFR DDR2 KRAS KIT
9	digestive/alimentary	MP:0005381	10.17	FBXW7 EGFR HRAS KRAS KIT NKX2-1
10	nervous system	MP:0003631	10.17	FBXW7 EGFR ALK DDR2 KRAS KIT
11	neoplasm	MP:0002006	10.16	FBXW7 EGFR ALK DDR2 KIT HRAS
12	no phenotypic analysis	MP:0003012	10.01	DDR2 EGFR HRAS KRAS KIT NKX2-1
13	muscle	MP:0005369	9.95	EGFR DDR2 KIT PDGFRA KRAS PIK3CA
14	limbs/digits/tail	MP:0005371	9.91	EGFR DDR2 KIT PDGFRA KRAS
15	normal	MP:0002873	9.91	EGFR HRAS FBXW7 KIT PDGFRA NKX2-1
16	reproductive system	MP:0005389	9.86	DDR2 ALK EGFR KRAS KIT NKX2-1
17	respiratory system	MP:0005388	9.81	FBXW7 EGFR ALK KRAS KIT HRAS
18	pigmentation	MP:0001186	9.72	ALK EGFR KRAS KIT PDGFRA
19	skeleton	MP:0005390	9.61	DDR2 ALK EGFR HRAS KRAS KIT
20	vision/eye	MP:0005391	9.23	DDR2 ALK EGFR KRAS FBXW7 KIT

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Drugs & Therapeutics for Lung Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Adenoid Cystic Carcinoma

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Genetic Tests for Lung Adenoid Cystic Carcinoma

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Anatomical Context for Lung Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Lung Adenoid Cystic Carcinoma:

⁴¹

Lung

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Publications for Lung Adenoid Cystic Carcinoma

Articles related to Lung Adenoid Cystic Carcinoma:

#	Title	Authors	Year
1	Primary Mediastinal Synovial Sarcoma with subsequent development of Primary Adenoid Cystic Carcinoma of Lung presenting as superior vena cava syndrome. ( 26992072 )	Madabhavi I....Parikh S.	2016
2	Primary adenoid cystic carcinoma of lung: a case report and review of the literature. ( 23771382 )	Bhattacharyya T....Sharma S.C.	2013

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Genes for Lung Adenoid Cystic Carcinoma

Genes related to Lung Adenoid Cystic Carcinoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	22.02	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
2	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	17.87	GeneCards inferred via : Variants (show sections)
3	DDR2	Discoidin Domain Receptor Tyrosine Kinase 2	Protein Coding	15.69	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	NKX2-1	NK2 Homeobox 1	Protein Coding	14.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	14.47	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	14.3	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	NFIB	Nuclear Factor I B	Protein Coding	14.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.88	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	13.31	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	13.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	EGFR	Epidermal Growth Factor Receptor	Protein Coding	13.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	EML4	Echinoderm Microtubule Associated Protein Like 4	Protein Coding	3.34	DISEASES inferred ¹⁵

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Variations for Lung Adenoid Cystic Carcinoma

Cosmic variations for Lung Adenoid Cystic Carcinoma:

⁹

(show top 50) (show all 548)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM6966579	ZFHX3	lung,NS,carcinoma,undifferentiated carcinoma	c.1172A>G	p.Q391R	16:72958974-72958974	7
2	COSM6953383	ZFHX3	lung,NS,carcinoma,undifferentiated carcinoma	c.1144G>T	p.G382C	16:72959002-72959002	7
3	COSM6980872	YAP1	lung,NS,carcinoma,undifferentiated carcinoma	c.1142C>T	p.P381L	11:102229729-102229729	7
4	COSM95548	XRCC6	lung,NS,carcinoma,undifferentiated carcinoma	c.1159A>C	p.I387L	22:41653558-41653558	7
5	COSM95544	XRCC1	lung,NS,carcinoma,undifferentiated carcinoma	c.1207A>G	p.M403V	19:43546970-43546970	7
6	COSM6980399	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.233G>A	p.W78*	11:32434909-32434909	7
7	COSM6938307	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.1156A>T	p.K386*	11:32392044-32392044	7
8	COSM95531	WNT8A	lung,NS,carcinoma,undifferentiated carcinoma	c.368G>C	p.G123A	5:138088927-138088927	7
9	COSM95521	WNT10B	lung,NS,carcinoma,undifferentiated carcinoma	c.1006A>C	p.K336Q	12:48966259-48966259	7
10	COSM95485	USP5	lung,NS,carcinoma,undifferentiated carcinoma	c.755C>T	p.T252I	12:6856877-6856877	7
11	COSM95476	USP38	lung,NS,carcinoma,undifferentiated carcinoma	c.994G>C	p.A332P	4:143197868-143197868	7
12	COSM96265	USP32	lung,NS,carcinoma,undifferentiated carcinoma	c.192T>A	p.I64I	17:60301699-60301699	7
13	COSM94159	UBR5	lung,NS,carcinoma,undifferentiated carcinoma	c.1555A>G	p.S519G	8:102326590-102326590	7
14	COSM94158	UBR5	lung,NS,carcinoma,undifferentiated carcinoma	c.2691A>T	p.Q897H	8:102305221-102305221	7
15	COSM6983597	U2AF1	lung,NS,carcinoma,undifferentiated carcinoma	c.319G>C	p.D107H	21:43095467-43095467	7
16	COSM95420	TYK2	lung,NS,carcinoma,undifferentiated carcinoma	c.3560G>T	p.C1187F	19:10350838-10350838	7
17	COSM6942934	TSHR	lung,NS,carcinoma,undifferentiated carcinoma	c.1922C>T	p.S641L	14:81143980-81143980	7
18	COSM6953382	TSHR	lung,NS,carcinoma,undifferentiated carcinoma	c.937A>C	p.K313Q	14:81142995-81142995	7
19	COSM6966576	TSHR	lung,NS,carcinoma,undifferentiated carcinoma	c.412C>T	p.L138F	14:81091088-81091088	7
20	COSM6980873	TSC2	lung,NS,carcinoma,undifferentiated carcinoma	c.1840G>T	p.A614S	16:2071510-2071510	7
21	COSM6980394	TSC1	lung,NS,carcinoma,undifferentiated carcinoma	c.694G>T	p.E232*	9:132921406-132921406	7
22	COSM6980408	TRAF7	lung,NS,carcinoma,undifferentiated carcinoma	c.1193C>T	p.P398L	16:2173978-2173978	7
23	COSM6940747	TRAF7	lung,NS,carcinoma,undifferentiated carcinoma	c.1287C>G	p.Y429*	16:2174274-2174274	7
24	COSM95390	TRAF5	lung,NS,carcinoma,undifferentiated carcinoma	c.302G>C	p.R101T	1:211356392-211356392	7
25	COSM22908	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.376-1G>T	p.?	17:7675237-7675237	7
26	COSM11232	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.842A>G	p.D281G	17:7673778-7673778	7
27	COSM45304	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.375+1G>A	p.?	17:7675993-7675993	7
28	COSM10768	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.535C>T	p.H179Y	17:7675077-7675077	7
29	COSM10742	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.578A>G	p.H193R	17:7674953-7674953	7
30	COSM11333	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.499C>T	p.Q167*	17:7675113-7675113	7
31	COSM10779	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.818G>T	p.R273L	17:7673802-7673802	7
32	COSM11354	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.991C>T	p.Q331*	17:7673537-7673537	7
33	COSM11073	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.1024C>T	p.R342*	17:7670685-7670685	7
34	COSM6815	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.461G>T	p.G154V	17:7675151-7675151	7
35	COSM43750	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.811G>T	p.E271*	17:7673809-7673809	7
36	COSM6913	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.783-1G>T	p.?	17:7673838-7673838	7
37	COSM10645	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.527G>T	p.C176F	17:7675085-7675085	7
38	COSM44295	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.993+1G>A	p.?	17:7673534-7673534	7
39	COSM13584	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.919+1G>T	p.?	17:7673700-7673700	7
40	COSM10660	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.818G>A	p.R273H	17:7673802-7673802	7
41	COSM43753	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.560-1G>A	p.?	17:7674972-7674972	7
42	COSM44240	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.514G>T	p.V172F	17:7675098-7675098	7
43	COSM44891	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.796G>T	p.G266*	17:7673824-7673824	7
44	COSM10889	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.536A>G	p.H179R	17:7675076-7675076	7
45	COSM10714	TP53	lung,NS,carcinoma,undifferentiated carcinoma	c.473G>T	p.R158L	17:7675139-7675139	7
46	COSM95367	TLR5	lung,NS,carcinoma,undifferentiated carcinoma	c.1A>G	p.M1V	1:223113031-223113031	7
47	COSM95359	TLR4	lung,NS,carcinoma,undifferentiated carcinoma	c.337C>A	p.P113T	9:117712465-117712465	7
48	COSM95356	TLR2	lung,NS,carcinoma,undifferentiated carcinoma	c.1169A>G	p.Q390R	4:153704076-153704076	7
49	COSM95347	TLN1	lung,NS,carcinoma,undifferentiated carcinoma	c.1087C>T	p.P363S	9:35721665-35721665	7
50	COSM95342	TLN1	lung,NS,carcinoma,undifferentiated carcinoma	c.5624C>T	p.S1875L	9:35705660-35705660	7

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Expression for Lung Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Lung Adenoid Cystic Carcinoma.

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Pathways for Lung Adenoid Cystic Carcinoma

Pathways related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 98)

#	Super pathways	Score	Top Affiliating Genes
1	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.67	ALK DDR2 EGFR HRAS KIT KRAS
2	HIV Life Cycle ⁶⁶ Show member pathways 2-LTR circle formation ⁶⁶ APOBEC3G mediated resistance to HIV-1 infection ⁶⁶ Assembly Of The HIV Virion ⁶⁶ Binding and entry of HIV virion ⁶⁶ Disease ⁶⁶ Diseases of signal transduction ⁶⁶ Early Phase of HIV Life Cycle ⁶⁶ HIV Infection ⁶⁶ Host Interactions of HIV factors ⁶⁶ Infectious disease ⁶⁶ Integration of provirus ⁶⁶ Late Phase of HIV Life Cycle ⁶⁶	13.66	EGFR FBXW7 HRAS KIT KRAS PDGFRA
3	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.62	ALK DDR2 EGFR HRAS KIT KRAS
4	Activation of cAMP-Dependent PKA ⁶⁴ Show member pathways Activation of PKA through GPCR ⁶⁴ cAMP Pathway ⁶⁴ PKA Signaling ⁶⁴	13.51	ALK DDR2 EGFR HRAS KIT KRAS
5	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.45	EGFR HRAS KIT KRAS PDGFRA PIK3CA
6	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.45	ALK DDR2 EGFR HRAS KIT KRAS
7	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁶	13.41	EGFR FBXW7 HRAS KIT KRAS PDGFRA
8	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.36	ALK DDR2 EGFR HRAS KIT KRAS
9	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.31	EGFR HRAS KIT KRAS PDGFRA PIK3CA
10	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	13.27	ALK DDR2 EGFR HRAS KIT KRAS
11	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	13.2	ALK DDR2 EGFR HRAS KIT KRAS
12	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	13.02	EGFR HRAS KIT KRAS PDGFRA
13	Actin Nucleation by ARP-WASP Complex ⁶⁴ Show member pathways Actin Nucleation and Branching ⁶⁴ CDC42 Pathway ⁶⁴ RhoA Pathway ⁶⁴	12.93	ALK DDR2 EGFR KIT PDGFRA
14	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.93	EGFR HRAS KIT KRAS PDGFRA PIK3CA
15	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.9	EGFR HRAS KIT KRAS PDGFRA PIK3CA
16	Focal Adhesion ³⁷ ¹ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.87	EGFR HRAS KRAS PDGFRA PIK3CA
17	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	12.86	ALK DDR2 EGFR HRAS KIT KRAS
18	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.84	EGFR HRAS KRAS PDGFRA PIK3CA
19	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.79	EGFR HRAS KIT KRAS PDGFRA PIK3CA
20	MAPK signaling pathway ¹ ³⁷	12.75	EGFR HRAS KIT KRAS PDGFRA
21	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.74	EGFR HRAS KIT KRAS PIK3CA
22	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁷ Inflammatory mediator regulation of TRP channels ³⁷	12.64	EGFR HRAS KRAS PIK3CA
23	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.63	EGFR HRAS KRAS PDGFRA
24	Regulation of IFNA signaling ⁶⁶ Show member pathways Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Jak-STAT signaling pathway ³⁷	12.61	EGFR HRAS PDGFRA PIK3CA
25	Regulation of actin cytoskeleton ³⁷ ¹	12.61	EGFR HRAS KRAS PDGFRA PIK3CA
26	Ras signaling pathway ³⁷ Show member pathways Rap1 signaling pathway ³⁷	12.61	EGFR HRAS KIT KRAS PDGFRA PIK3CA
27	Downstream signaling events of B Cell Receptor (BCR) ⁶⁶ Show member pathways Activation of RAS in B cells ⁶⁶ Signaling by the B Cell Receptor (BCR) ⁶⁶	12.59	EGFR HRAS KIT KRAS PDGFRA PIK3CA
28	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.56	EGFR HRAS KRAS PDGFRA PIK3CA
29	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.51	EGFR HRAS KRAS PIK3CA
30	MicroRNAs in cancer ³⁷	12.47	EGFR HRAS KRAS PDGFRA PIK3CA
31	ErbB signaling pathway ¹ ³⁷ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.46	EGFR HRAS KRAS PIK3CA
32	mTOR signaling pathway (KEGG) ⁶⁵ Show member pathways mTOR signaling pathway ³⁷	12.44	EGFR HRAS KRAS PDGFRA PIK3CA
33	HTLV-I infection ³⁷	12.41	HRAS KRAS PDGFRA PIK3CA
34	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.39	EGFR HRAS KRAS PIK3CA
35	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.38	EGFR HRAS KRAS PDGFRA PIK3CA
36	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.37	ALK EGFR EML4 HRAS KRAS PDGFRA
37	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.32	EGFR HRAS PDGFRA PIK3CA
38	Signaling by ERBB2 ⁶⁶ Show member pathways Downregulation of ERBB2 signaling ⁶⁶ Downregulation of ERBB2-ERBB3 signaling ⁶⁶ ERBB2 Activates PTK6 Signaling ⁶⁶ ERBB2 Regulates Cell Motility ⁶⁶ GRB2 events in ERBB2 signaling ⁶⁶ GRB7 events in ERBB2 signaling ⁶⁶ PI3K events in ERBB2 signaling ⁶⁶ PI3K events in ERBB4 signaling ⁶⁶ PLCG1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB4 signaling ⁶⁶	12.31	EGFR HRAS KRAS PIK3CA
39	Proteoglycans in cancer ³⁷	12.29	EGFR HRAS KRAS PIK3CA
40	Pathways in cancer ³⁷	12.28	ALK EGFR EML4 HRAS KIT KRAS
41	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	12.21	HRAS KRAS PIK3CA
42	VEGF Signaling Pathway ⁶⁷ ⁶¹ Show member pathways Nanoparticle-mediated activation of receptor signaling ¹ TGF-beta Signaling ⁶⁷	12.2	EGFR HRAS KRAS
43	Axon guidance ³⁷	12.19	HRAS KRAS PIK3CA
44	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.19	HRAS KRAS PIK3CA
45	EGF/EGFR Signaling Pathway ¹	12.16	EGFR HRAS KRAS
46	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	12.15	HRAS KIT PIK3CA
47	mTOR Pathway ⁷² Show member pathways Insulin Pathway ⁷² TGF-beta Pathway ⁷²	12.15	HRAS KRAS PIK3CA
48	Cellular senescence (KEGG) ³⁷	12.15	HRAS KRAS PIK3CA
49	Signaling by FGFR2 in disease ⁶⁶ Show member pathways FGFR2 mutant receptor activation ⁶⁶ Signaling by FGFR in disease ⁶⁶ Signaling by FGFR2 IIIa TM ⁶⁶	12.14	HRAS KRAS PIK3CA
50	Phospholipase D signaling pathway ³⁷ Show member pathways Choline metabolism in cancer ³⁷	12.12	EGFR HRAS KIT KRAS PDGFRA PIK3CA

Sources

GO Terms for Lung Adenoid Cystic Carcinoma

Cellular components related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	9.65	ALK DDR2 EGFR EML4 FBXW7 HRAS
2	receptor complex	GO:0043235	9.02	ALK DDR2 EGFR KIT PDGFRA

Biological processes related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 39)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.97	DDR2 EGFR HRAS KIT KRAS PDGFRA
2	positive regulation of gene expression	GO:0010628	9.96	HRAS KIT KRAS NKX2-1
3	MAPK cascade	GO:0000165	9.92	EGFR HRAS KIT KRAS PDGFRA
4	positive regulation of cell migration	GO:0030335	9.91	EGFR HRAS KIT PDGFRA
5	axon guidance	GO:0007411	9.89	HRAS KRAS NKX2-1 PIK3CA
6	positive regulation of protein kinase B signaling	GO:0051897	9.87	EGFR KIT PDGFRA PIK3CA
7	positive regulation of protein phosphorylation	GO:0001934	9.85	EGFR HRAS KRAS
8	negative regulation of neuron apoptotic process	GO:0043524	9.84	HRAS KRAS PIK3CA
9	phosphatidylinositol phosphorylation	GO:0046854	9.84	EGFR KIT PDGFRA PIK3CA
10	animal organ morphogenesis	GO:0009887	9.83	HRAS NKX2-1 PDGFRA
11	protein autophosphorylation	GO:0046777	9.83	ALK DDR2 EGFR KIT PDGFRA
12	liver development	GO:0001889	9.81	EGFR KRAS PIK3CA
13	lung development	GO:0030324	9.81	EGFR NFIB NKX2-1 PDGFRA
14	cell chemotaxis	GO:0060326	9.8	KIT PDGFRA PIK3CA
15	peptidyl-tyrosine phosphorylation	GO:0018108	9.8	ALK DDR2 EGFR KIT PDGFRA
16	positive regulation of MAP kinase activity	GO:0043406	9.78	EGFR HRAS KIT KRAS
17	positive regulation of fibroblast proliferation	GO:0048146	9.77	DDR2 EGFR PDGFRA
18	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.77	ALK DDR2 EGFR KIT PDGFRA
19	epidermal growth factor receptor signaling pathway	GO:0007173	9.76	EGFR HRAS KRAS PIK3CA
20	positive regulation of DNA replication	GO:0045740	9.75	EGFR HRAS PDGFRA
21	vasculature development	GO:0001944	9.68	FBXW7 PIK3CA
22	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.67	HRAS KRAS
23	epithelial tube branching involved in lung morphogenesis	GO:0060441	9.66	KRAS NKX2-1
24	cerebral cortex cell migration	GO:0021795	9.65	EGFR NKX2-1
25	tongue development	GO:0043586	9.65	EGFR KIT
26	negative regulation of signal transduction	GO:0009968	9.65	ALK DDR2 EGFR KIT PDGFRA
27	Leydig cell differentiation	GO:0033327	9.64	NKX2-1 PDGFRA
28	positive regulation of phospholipase C activity	GO:0010863	9.63	KIT PDGFRA
29	response to isolation stress	GO:0035900	9.62	HRAS KRAS
30	ERBB2 signaling pathway	GO:0038128	9.62	EGFR HRAS KRAS PIK3CA
31	Type II pneumocyte differentiation	GO:0060510	9.61	NFIB NKX2-1
32	Clara cell differentiation	GO:0060486	9.58	NFIB NKX2-1
33	positive regulation of kinase activity	GO:0033674	9.55	ALK DDR2 EGFR KIT PDGFRA
34	positive regulation of MAPK cascade	GO:0043410	9.43	ALK DDR2 EGFR HRAS KIT PDGFRA
35	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.17	ALK DDR2 EGFR FBXW7 HRAS KIT
36	cell differentiation	GO:0030154	10.08	ALK DDR2 EGFR KIT PDGFRA
37	phosphorylation	GO:0016310	10.03	ALK DDR2 EGFR KIT PDGFRA PIK3CA
38	negative regulation of apoptotic process	GO:0043066	10.02	ALK DDR2 EGFR KIT PDGFRA
39	protein phosphorylation	GO:0006468	10.02	ALK DDR2 EGFR KIT PDGFRA PIK3CA

Molecular functions related to Lung Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:0005524	9.99	ALK DDR2 EGFR KIT PDGFRA PIK3CA
2	protein kinase activity	GO:0004672	9.85	ALK DDR2 EGFR KIT PDGFRA
3	kinase activity	GO:0016301	9.85	ALK DDR2 EGFR KIT PDGFRA PIK3CA
4	nucleotide binding	GO:0000166	9.83	EGFR HRAS KIT KRAS PDGFRA
5	transmembrane signaling receptor activity	GO:0004888	9.8	ALK DDR2 EGFR KIT PDGFRA
6	Ras guanyl-nucleotide exchange factor activity	GO:0005088	9.67	EGFR KIT PDGFRA
7	protein tyrosine kinase activity	GO:0004713	9.65	ALK DDR2 EGFR KIT PDGFRA
8	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	9.62	EGFR KIT PDGFRA PIK3CA
9	MAP kinase kinase kinase activity	GO:0004709	9.55	ALK DDR2 EGFR KIT PDGFRA
10	obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity	GO:0004716	9.48	EGFR KIT
11	mitogen-activated protein kinase kinase binding	GO:0031434	9.35	ALK DDR2 EGFR KIT PDGFRA
12	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.02	ALK DDR2 EGFR KIT PDGFRA

Sources

Sources for Lung Adenoid Cystic Carcinoma

¹ BioSystems

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⁷¹ TGDB

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