Lung Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LNG030 MIFTS: 40	Lung Adenoma Categories: Cancer diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Lung Adenoma

MalaCards integrated aliases for Lung Adenoma:

Name: Lung Adenoma ¹¹ ¹⁴

Adenoma of Lung ¹¹ ⁷¹

Pulmonary Adenoma ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5386

NCIt ⁴⁹ C4455

SNOMED-CT ⁶⁸ 254642004

UMLS ⁷¹ C0345964

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Summaries for Lung Adenoma

Disease Ontology: ¹¹ A lung benign neoplasm that derives from glandular epithelial cells.

MalaCards based summary: Lung Adenoma, also known as adenoma of lung, is related to adenoma and lung benign neoplasm. An important gene associated with Lung Adenoma is C18orf54 (Chromosome 18 Open Reading Frame 54), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Affiliated tissues include lung, skin and breast, and related phenotypes are Decreased viability and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Lung Adenoma

Diseases related to Lung Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 388)

#	Related Disease	Score	Top Affiliating Genes
1	adenoma	30.7	TP53 MYC KRAS HRAS CDKN2A CCND1
2	lung benign neoplasm	30.3	TP53 SFTPC SCGB1A1 KRAS HRAS EGFR
3	skin papilloma	29.4	TP53 PTEN MYC HRAS EGFR CCND1
4	adenocarcinoma	29.3	TP53 PTEN MAPK3 KRAS HRAS EGFR
5	papilloma	29.3	TP53 PTEN KRAS EGFR CDKN2A CCND1
6	lung squamous cell carcinoma	29.3	TP53 PTEN KRAS HRAS H2AC18 EGFR
7	lung cancer susceptibility 3	28.6	TP53 SFTPC SCGB1A1 RAF1 MYC KRAS
8	lung cancer	28.5	TP53 SCGB1A1 RAF1 PTEN MYC MIR30C1
9	common bile duct neoplasm	10.4	KRAS HRAS
10	ampulla of vater benign neoplasm	10.4	KRAS HRAS
11	vaginal carcinosarcoma	10.4	TP53 KRAS HRAS
12	bladder urachal carcinoma	10.4	KRAS HRAS
13	liver angiosarcoma	10.4	TP53 KRAS HRAS
14	cystadenofibroma	10.4	TP53 KRAS HRAS
15	endosalpingiosis	10.4	TP53 KRAS HRAS
16	hepatic flexure cancer	10.4	KRAS HRAS
17	appendix adenocarcinoma	10.4	TP53 KRAS HRAS
18	large cell carcinoma with rhabdoid phenotype	10.3	TP53 KRAS HRAS
19	urachus cancer	10.3	KRAS HRAS
20	pancreatic signet ring cell adenocarcinoma	10.3	TP53 KRAS HRAS
21	signet ring cell adenocarcinoma	10.3	TP53 KRAS HRAS
22	biliary tract benign neoplasm	10.3	TP53 KRAS HRAS
23	small intestine adenocarcinoma	10.3	TP53 KRAS HRAS
24	appendix disease	10.3	TP53 KRAS HRAS
25	endometrial mucinous adenocarcinoma	10.3	KRAS CDKN2A
26	appendix cancer	10.3	TP53 KRAS HRAS
27	ovarian benign neoplasm	10.3	TP53 KRAS HRAS
28	high-grade astrocytoma	10.3	TP53 PTEN
29	klatskin's tumor	10.3	TP53 KRAS HRAS
30	descending colon cancer	10.3	KRAS HRAS
31	villous adenoma	10.3	TP53 KRAS HRAS
32	papillary serous adenocarcinoma	10.3	TP53 KRAS HRAS
33	tonsillar pillar cancer	10.3	EGFR CDKN2A
34	duodenum cancer	10.3	TP53 KRAS HRAS
35	duodenum disease	10.3	TP53 KRAS HRAS
36	mucinous intrahepatic cholangiocarcinoma	10.3	KRAS HRAS
37	adenosquamous lung carcinoma	10.3	KRAS HRAS EGFR
38	bronchial benign neoplasm	10.3	SFTPC SCGB1A1 HRAS
39	cervical adenocarcinoma	10.3	TP53 KRAS CDKN2A
40	mucinous lung adenocarcinoma	10.3	KRAS HRAS EGFR
41	trachea carcinoma in situ	10.3	KRAS HRAS CDKN2A
42	b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	10.3	TP53 CDKN2A
43	sigmoid neoplasm	10.3	KRAS HRAS
44	papillary adenocarcinoma	10.3	TP53 KRAS HRAS
45	paronychia	10.3	KRAS HRAS EGFR
46	endometrial squamous cell carcinoma	10.3	TP53 CDKN2A
47	lung sarcomatoid carcinoma	10.3	KRAS HRAS EGFR
48	dermatopathia pigmentosa reticularis	10.3	KRAS HRAS EGFR
49	appendiceal neoplasm	10.3	KRAS HRAS
50	lung non-squamous non-small cell carcinoma	10.3	KRAS HRAS EGFR

Graphical network of the top 20 diseases related to Lung Adenoma:

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Symptoms & Phenotypes for Lung Adenoma

GenomeRNAi Phenotypes related to Lung Adenoma according to GeneCards Suite gene sharing:

²⁵ (show all 19)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	10.47	EGFR HRAS KRAS
2	Decreased viability	GR00055-A-2	10.47	EGFR HRAS KRAS
3	Decreased viability	GR00055-A-3	10.47	KRAS
4	Decreased viability	GR00106-A-0	10.47	KRAS
5	Decreased viability	GR00221-A-1	10.47	AKT1 CDKN2A EGFR HRAS KRAS MYC
6	Decreased viability	GR00221-A-2	10.47	AKT1 HRAS KRAS RAF1
7	Decreased viability	GR00221-A-3	10.47	AKT1 CDKN2A HRAS MYC
8	Decreased viability	GR00221-A-4	10.47	AKT1 CDKN2A EGFR
9	Decreased viability	GR00249-S	10.47	AKT1 MYC
10	Decreased viability	GR00301-A	10.47	KRAS RAF1
11	Decreased viability	GR00381-A-1	10.47	KRAS
12	Decreased viability	GR00402-S-2	10.47	MYC RAF1
13	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.84	AKT1 CDKN2A DNAI7 LMNTD1 MAPK3 PTEN
14	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.84	AKT1 CDKN2A DNAI7 LMNTD1 PTEN RAF1
15	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.84	MAPK3 TP53
16	Increased cell migration	GR00055-A-1	9.46	MAPK3
17	Increased cell migration	GR00055-A-3	9.46	MAPK3
18	Decreased viability with paclitaxel	GR00179-A-1	9.26	EGFR MAPK3
19	Decreased viability with paclitaxel	GR00179-A-3	9.26	EGFR MAPK3

MGI Mouse Phenotypes related to Lung Adenoma:

⁴⁵ (show all 17)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	10.4	AKT1 CCND1 CDKN2A DNAI7 EGFR HRAS
2	homeostasis/metabolism	MP:0005376	10.34	AKT1 CCND1 CDKN2A DNAI7 EGFR HRAS
3	endocrine/exocrine gland	MP:0005379	10.26	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
4	normal	MP:0002873	10.25	AKT1 CCND1 EGFR HRAS KRAS MYC
5	muscle	MP:0005369	10.22	AKT1 CDKN2A EGFR HRAS KRAS MAPK3
6	no phenotypic analysis	MP:0003012	10.19	CDKN2A EGFR HRAS KRAS MIR30C1 MYC
7	liver/biliary system	MP:0005370	10.16	AKT1 CDKN2A EGFR KRAS MAPK3 MYC
8	cardiovascular system	MP:0005385	10.15	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
9	embryo	MP:0005380	10.11	AKT1 CDKN2A EGFR KRAS MAPK3 MYC
10	immune system	MP:0005387	10.1	AKT1 CCND1 CDKN2A EGFR KRAS MAPK3
11	digestive/alimentary	MP:0005381	10.09	CCND1 CDKN2A EGFR HRAS KRAS MAPK3
12	pigmentation	MP:0001186	10.04	CDKN2A EGFR KRAS MYC PTEN TP53
13	respiratory system	MP:0005388	10.03	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
14	craniofacial	MP:0005382	10.01	CCND1 EGFR HRAS KRAS MAPK3 MYC
15	skeleton	MP:0005390	9.9	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
16	mortality/aging	MP:0010768	9.8	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
17	integument	MP:0010771	9.4	AKT1 CCND1 CDKN2A EGFR HRAS IRAG2

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Drugs & Therapeutics for Lung Adenoma

Search Clinical Trials, NIH Clinical Center for Lung Adenoma

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Genetic Tests for Lung Adenoma

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Anatomical Context for Lung Adenoma

Organs/tissues related to Lung Adenoma:

MalaCards : Lung, Skin, Breast, Liver, Brain

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Publications for Lung Adenoma

Articles related to Lung Adenoma:

(show top 50) (show all 328)

#	Title	Authors	PMID	Year
1	Assessing the Vulnerability of Cancer Patients for COVID-19. ⁶²	Bhatia S...Sirigiri DNR	36237732	2022
2	Iloprost requires the Frizzled-9 receptor to prevent lung cancer. ⁶²	Sompel K...Tennis MA	35707728	2022
3	Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment. ⁶²	Kamata T...Pritchard C	34779486	2022
4	Molecular cytogenetic characterization of the urethane-induced murine lung cell line LA-4 as a model for human squamous cell lung cancer. ⁶²	Azawi S...Liehr T	34881029	2022
5	Pulmonary Aerosol Delivery of Let-7b microRNA Confers a Striking Inhibitory Effect on Lung Carcinogenesis through Targeting the Tumor Immune Microenvironment. ⁶²	Zhang Q...You M	34236760	2021
6	Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung. ⁶²	Peterson LA...Wiedmann TS	33629582	2021
7	Impact of Deleterious Mutations on Structure, Function and Stability of Serum/Glucocorticoid Regulated Kinase 1: A Gene to Diseases Correlation. ⁶²	AlAjmi MF...Hassan MI	34805284	2021
8	Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice. ⁶²	Hu Q...Xing C	32476407	2020
9	Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells. ⁶²	Lim KS...Voon DC	32209656	2020
10	Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer. ⁶²	Wang H...Wang XJ	31811110	2019
11	Toxicological evaluation of carcinogenicity of the pyrethroid imiprothrin in rats and mice. ⁶²	Yamada T...Cohen SM	30905765	2019
12	Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice. ⁶²	Zhang Q...You M	30873838	2019
13	Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. ⁶²	Qiang L...Liu CH	29572547	2019
14	CD44 facilitates adherence of Streptococcus equi subsp. zooepidemicus to LA-4 cells. ⁶²	Fu Q...Liu X	30639625	2019
15	Antitumor and anti-metastatic mechanisms of Rhizoma paridis saponins in Lewis mice. ⁶²	Man S...Gao W	29148169	2018
16	Mequindox Induced Genotoxicity and Carcinogenicity in Mice. ⁶²	Liu Q...Yuan Z	29692735	2018
17	Effects of talactoferrin alpha on lung adenoma prevention in A/J mice June 2, 2016. ⁶²	Seabloom DE...Wattenberg LW	29636877	2018
18	Complex genetic control of lung tumorigenesis in resistant mice strains. ⁶²	Dassano A...Manenti G	28796413	2017
19	The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model. ⁶²	Dwyer-Nield L...Keith RL	28851689	2017
20	p53 loss does not permit escape from BrafV600E-induced senescence in a mouse model of lung cancer. ⁶²	Garnett S...Dankort D	28745322	2017
21	Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis. ⁶²	Liu J...DeMayo FJ	29191600	2017
22	The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation. ⁶²	Wang J...Liu CH	28811474	2017
23	High-energy particle beam and gamma radiation exposure, familial relatedness and cancer in mice. ⁶²	Chernyavskiy P...Little MP	28535153	2017
24	An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. ⁶²	Yamada T...Cohen SM	28431163	2017
25	Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance. ⁶²	Wang W...Wang S	28260069	2017
26	Inhibition of pulmonary carcinoma proliferation or metastasis of miR-218 via down-regulating CDCP1 expression. ⁶²	Zeng XJ...Yu H	28429357	2017
27	A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis. ⁶²	Wang JZ...Xu P	28253859	2017
28	Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention. ⁶²	Seabloom DE...Ondrey FG	28052934	2017
29	Safety and Preclinical Efficacy of Aerosol Pioglitazone on Lung Adenoma Prevention in A/J Mice. ⁶²	Seabloom DE...Ondrey FG	27993834	2017
30	[Metastatic pleomorphic adenoma of lung: report of a case]. ⁶²	Zhang DM...Wei JG	28072982	2017
31	Changes of serum amino acid profiles by an epidermal growth factor receptor mutation and benzo[a]pyrene in mouse lung tumorigenesis. ⁶²	Lin P...Lee HL	30090424	2016
32	Expression quantitative trait analysis reveals fine germline transcript regulation in mouse lung tumors. ⁶²	Cotroneo CE...Manenti G	26966001	2016
33	Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. ⁶²	Manteghi S...Pause A	27210750	2016
34	Uridine homeostatic disorder leads to DNA damage and tumorigenesis. ⁶²	Cao Z...Cao D	26801745	2016
35	Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway. ⁶²	Jiang Y...Yang J	26472723	2016
36	How do K-RAS-activated cells evade cellular defense mechanisms? ⁶²	Lee YS...Bae SC	25961920	2016
37	Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice. ⁶²	Kumar G...Rao CV	27293987	2016
38	Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice. ⁶²	Patlolla JM...Rao CV	26397133	2015
39	Inhibition of pulmonary adenoma in diethylnitrosamine-induced rats by Rhizoma paridis saponins. ⁶²	Man S...Gao W	26196122	2015
40	Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. ⁶²	Zandvakili I...Zheng Y	26030593	2015
41	Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses. ⁶²	Waalkes MP...Dixon D	25005685	2014
42	The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice. ⁶²	Iguchi M...Lee GH	23955086	2014
43	Mouse pulmonary adenoma susceptibility 1 locus is an expression QTL modulating Kras-4A. ⁶²	Dassano A...Manenti G	24743582	2014
44	Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells. ⁶²	Gotz R...Sendtner M	24959744	2014
45	ALDH maintains the stemness of lung adenoma stem cells by suppressing the Notch/CDK2/CCNE pathway. ⁶²	Li Z...Hao P	24671051	2014
46	Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. ⁶²	Leitzman P...Xing C	24403291	2014
47	Genetic linkage analysis identifies Pas1 as the common locus modulating lung tumorigenesis and acute inflammatory response in mice. ⁶²	Galvan A...Ibanez OC	24067788	2013
48	Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice. ⁶²	Tago Y...Wanibuchi H	24106881	2013
49	β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells. ⁶²	Patlolla JM...Rao CV	23963803	2013
50	Xiao-Qing-Long-Tang shows preventive effect of asthma in an allergic asthma mouse model through neurotrophin regulation. ⁶²	Chang RS...Wang JY	24010817	2013

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Genes for Lung Adenoma

Genes related to Lung Adenoma (0 elite genes):

(show all 28)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	C18orf54	Chromosome 18 Open Reading Frame 54	Protein Coding	21.81	DISEASES inferred ¹⁴ GeneCards inferred via : Gene name Proteins (show sections)
2	DNAI7	Dynein Axonemal Intermediate Chain 7	Protein Coding	14.22	DISEASES inferred ¹⁴ GeneCards inferred via : Gene name (show sections)
3	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	7.08	DISEASES inferred ¹⁴
4	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	7.04	DISEASES inferred ¹⁴
5	ACTR3C	Actin Related Protein 3C	Protein Coding	6.94	GeneCards inferred via : Functions (show sections)
6	TP53	Tumor Protein P53	Protein Coding	6.37	DISEASES inferred ¹⁴
7	SCGB1A1	Secretoglobin Family 1A Member 1	Protein Coding	6.34	DISEASES inferred ¹⁴
8	MIR30C1	MicroRNA 30c-1	RNA Gene	6.32	DISEASES inferred ¹⁴ ¹⁴
9	H2AC18	H2A Clustered Histone 18	Protein Coding	6.31	DISEASES inferred ¹⁴ ¹⁴
10	IRAG2	Inositol 1,4,5-Triphosphate Receptor Associated 2	Protein Coding	6.3	DISEASES inferred ¹⁴
11	SFTPC	Surfactant Protein C	Protein Coding	6.22	DISEASES inferred ¹⁴
12	LMNTD1	Lamin Tail Domain Containing 1	Protein Coding	6.13	DISEASES inferred ¹⁴
13	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	5.54	DISEASES inferred ¹⁴
14	EGFR	Epidermal Growth Factor Receptor	Protein Coding	5.49	DISEASES inferred ¹⁴
15	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	5.48	DISEASES inferred ¹⁴
16	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	5.48	DISEASES inferred ¹⁴
17	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	5.27	DISEASES inferred ¹⁴
18	PTEN	Phosphatase And Tensin Homolog	Protein Coding	5.25	DISEASES inferred ¹⁴
19	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	5.19	DISEASES inferred ¹⁴
20	CCND1	Cyclin D1	Protein Coding	5.14	DISEASES inferred ¹⁴
21	OGG1	8-Oxoguanine DNA Glycosylase	Protein Coding	5.13	DISEASES inferred ¹⁴
22	LOX	Lysyl Oxidase	Protein Coding	5.07	DISEASES inferred ¹⁴
23	POLM	DNA Polymerase Mu	Protein Coding	5.04	DISEASES inferred ¹⁴
24	ACTB	Actin Beta	Protein Coding	5	DISEASES inferred ¹⁴
25	NKX2-1	NK2 Homeobox 1	Protein Coding	4.96	DISEASES inferred ¹⁴
26	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	4.94	DISEASES inferred ¹⁴
27	CASP3	Caspase 3	Protein Coding	4.91	DISEASES inferred ¹⁴
28	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	4.88	DISEASES inferred ¹⁴

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Variations for Lung Adenoma

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Expression for Lung Adenoma

Search GEO for disease gene expression data for Lung Adenoma.

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Pathways for Lung Adenoma

Pathways related to Lung Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 195)

#	Super pathways	Score	Top Affiliating Genes
1	Apoptotic Pathways in Synovial Fibroblasts ⁶⁴ Show member pathways Actin-Based Motility by Rho Family GTPases ⁶⁴ Cellular Apoptosis Pathway ⁶⁴ DHA Signaling ⁶⁴ eIF2 Pathway ⁶⁴ ERK5 Signaling ⁶⁴ Glioma Invasiveness ⁶⁴ Mitochondrial Apoptosis ⁶⁴ Nuclear Receptor Activation by Vitamin-A ⁶⁴ p53 Mediated Apoptosis ⁶⁴ PPAR Pathway ⁶⁴ Rac1 Pathway ⁶⁴ Rap1 Pathway ⁶⁴ Telomerase Components in Cell Signaling ⁶⁴	13.98	TP53 RAF1 PTEN MYC MAPK3 KRAS
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.98	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
3	Signal Transduction ⁶⁶	13.93	TP53 RAF1 PTEN MYC MAPK3 KRAS
4	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.93	TP53 SFTPC RAF1 PTEN MYC MAPK3
5	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.85	TP53 RAF1 MYC MAPK3 KRAS HRAS
6	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.74	TP53 RAF1 MYC MAPK3 KRAS HRAS
7	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.67	TP53 RAF1 MYC MAPK3 KRAS HRAS
8	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.61	TP53 RAF1 PTEN MYC MAPK3 KRAS
9	Integrin Pathway ⁶⁴ Show member pathways FAK1 Signaling ⁶⁴ GnRH Signaling ⁶⁴ Inhibition of Angiogenesis by TSP1 ⁶⁴ Transendothelial Migration of Leukocytes ⁶⁴ UPA-UPAR Pathway ⁶⁴	13.55	RAF1 PTEN MYC MAPK3 KRAS HRAS
10	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.55	TP53 RAF1 PTEN KRAS HRAS EGFR
11	RAF/MAP kinase cascade ⁶⁶ Show member pathways Diseases of signal transduction by growth factor receptors and second messengers ⁶⁶ MAPK family signaling cascades ⁶⁶ MAPK1/MAPK3 signaling ⁶⁶	13.52	AKT1 EGFR HRAS KRAS MAPK3 MYC
12	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	13.45	RAF1 PTEN MAPK3 KRAS HRAS EGFR
13	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.45	TP53 MYC MAPK3 KRAS HRAS CCND1
14	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	13.25	TP53 RAF1 PTEN MAPK3 KRAS HRAS
15	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	13.18	RAF1 MAPK3 KRAS HRAS EGFR AKT1
16	ESR-mediated signaling ⁶⁶ Show member pathways Estrogen-dependent gene expression ⁶⁶ RUNX1 regulates estrogen receptor mediated transcription ⁶⁶ Signaling by Nuclear Receptors ⁶⁶	13.17	MYC MAPK3 KRAS HRAS H2AC18 EGFR
17	TCR Signaling (Qiagen) ⁶⁴ Show member pathways Fc-EpsilonRI Pathway ⁶⁴ ITK and TCR Signaling ⁶⁴ PDGF Pathway ⁶⁴ PKC-Theta Pathway ⁶⁴	13.07	AKT1 HRAS KRAS MAPK3 RAF1 TP53
18	Sertoli-Sertoli Cell Junction Dynamics ⁶⁴ Show member pathways Epithelial Tight Junctions ⁶⁴ Germ Cell-Sertoli Cell Junction Dynamics ⁶⁴	13.07	RAF1 PTEN MAPK3 KRAS HRAS AKT1
19	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis ⁷⁴ Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis modulation by HSP70 ⁷⁴ Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ Ceramide signaling pathway ⁶¹ DR3 Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef: Negative effector of Fas and TNF-alpha ⁶¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF Signaling ⁶⁴ TNF-related weak inducer of apoptosis (TWEAK) signaling pathway ⁷⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	13.07	TP53 RAF1 PTEN MYC MAPK3 HRAS
20	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	13.05	AKT1 CCND1 EGFR HRAS KRAS MAPK3
21	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	13.04	AKT1 EGFR HRAS KRAS MAPK3 PTEN
22	IL-9 Signaling Pathways ⁶⁵ Show member pathways Adipocytokines and Insulin Signaling ⁶⁵ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Pathway ⁶⁴ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ Immune response IL-9 signaling pathway ²² Interleukin-9 signaling ⁶⁶	13.03	AKT1 CCND1 HRAS KRAS MAPK3 MYC
23	CCR5 Pathway in Macrophages ⁶⁴ Show member pathways Androgen Signaling ⁶⁴ Chemokine Signaling ⁶⁴ Chemokine signaling pathway ⁷⁴	13.01	RAF1 MAPK3 KRAS HRAS CCND1 AKT1
24	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	13.01	RAF1 MAPK3 KRAS HRAS EGFR AKT1
25	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	13.01	AKT1 CCND1 HRAS KRAS MAPK3 MYC
26	Beta-Adrenergic Signaling ⁶⁴ Show member pathways CDK5 Pathway ⁶⁴ Erythropoietin Pathway ⁶⁴ Insulin Pathway ⁷⁰ Insulin Receptor Pathway ⁶⁴	13	RAF1 MAPK3 KRAS HRAS AKT1
27	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.99	AKT1 EGFR HRAS KRAS MAPK3 MYC
28	Alzheimer's disease and miRNA effects ⁷⁴ Show member pathways Alzheimer's disease ⁷⁴	12.95	AKT1 HRAS KRAS MAPK3 RAF1
29	fMLP Pathway ⁶⁴ Show member pathways CXCR4 Pathway ⁶⁴ Huntington's Disease Pathway ⁶⁴ Internalin Pathway ⁶⁴ Signal transduction Activation of PKC via G-Protein coupled receptor ²²	12.94	TP53 RAF1 MAPK3 KRAS HRAS AKT1
30	Pre-NOTCH Expression and Processing ⁶⁶ Show member pathways Defective LFNG causes SCDO3 ⁶⁶ Pre-NOTCH Processing in Golgi ⁶⁶ Pre-NOTCH Processing in the Endoplasmic Reticulum ⁶⁶ Pre-NOTCH Transcription and Translation ⁶⁶ Signaling by NOTCH ⁶⁶	12.93	TP53 MYC H2AC18 EGFR CCND1 AKT1
31	Translation Insulin regulation of translation ²² Show member pathways Butyrate-induced histone acetylation ⁷⁴ Cell adhesion PLAU signaling ²² Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 ⁷⁴ Regulation of lipid metabolism Insulin signaling-generic cascades ²² Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation inhibitors in chronically activated PDGFRA cells ⁷⁴	12.91	RAF1 PTEN MAPK3 HRAS EGFR AKT1
32	DREAM Repression and Dynorphin Expression ⁶⁴ Show member pathways Arrhythmogenic right ventricular cardiomyopathy ⁷⁴ BMP Pathway ⁶⁴ Calpain Protease Regulates Cellular Mechanics ⁶⁴ Caspase Cascade ⁶⁴ nNOS Signaling in Skeletal Muscle ⁶⁴ Presynaptic depolarization and calcium channel opening ⁶⁶ TOB in Osteoblast Signaling ⁶⁴	12.9	MAPK3 KRAS HRAS EGFR CCND1
33	G-AlphaQ Signaling ⁶⁴ Show member pathways G-AlphaI Signaling ⁶⁴ PAR4-mediated thrombin signaling events ⁶¹ Thrombin Signaling ⁶⁴	12.86	AKT1 EGFR HRAS KRAS MAPK3 RAF1
34	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.85	TP53 RAF1 MAPK3 KRAS HRAS EGFR
35	G-protein signaling G-Protein alpha-i signaling cascades ²² Show member pathways Development Beta-adrenergic receptors regulation of ERK ²² G-protein signaling G-Protein alpha-s signaling cascades ²² G-protein signaling G-Protein beta/gamma signaling cascades ²² Signaling in Gap Junctions ⁶⁴	12.84	AKT1 EGFR HRAS KRAS MAPK3 RAF1
36	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴	12.84	AKT1 CDKN2A EGFR HRAS KRAS MAPK3
37	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.81	AKT1 EGFR HRAS KRAS MAPK3 MYC
38	CNTF Signaling ⁶⁴ Show member pathways Activation of the AP-1 family of transcription factors ⁶⁶ FLT3 Signaling ⁶⁴ G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Host-pathogen interaction of human coronaviruses - MAPK signaling ⁷⁴ IL-3 Pathway ⁶⁴ Immune response Oncostatin M signaling via MAPK in human cells ²² Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells ⁷⁴ MAPK cascade ⁷⁴ Nur77-Induced AICD in Macrophage ⁶⁴ OSM Pathway ⁶⁴	12.8	RAF1 MAPK3 KRAS HRAS AKT1
39	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.77	RAF1 MAPK3 KRAS HRAS EGFR
40	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.77	TP53 MYC MAPK3 KRAS HRAS EGFR
41	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²² Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²² Cell adhesion Tight junctions ²² Cytoskeleton remodeling Integrin outside-in signaling ²² Development MAG-dependent inhibition of neurite outgrowth ²²	12.74	RAF1 MAPK3 HRAS CCND1 AKT1
42	Malignant pleural mesothelioma ⁷⁴	12.74	TP53 RAF1 PTEN MYC MAPK3 HRAS
43	Angiopoietin-like protein 8 regulatory pathway ⁷⁴ Show member pathways Insulin signaling ⁷⁴ Liver X receptor pathway ⁷⁴	12.68	RAF1 PTEN MAPK3 HRAS AKT1
44	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.68	AKT1 CCND1 CDKN2A EGFR HRAS KRAS
45	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF and VEGFR signaling network ⁶¹ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.62	RAF1 MAPK3 KRAS HRAS EGFR AKT1
46	Hepatocyte growth factor receptor signaling ⁷⁴ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development HGF signaling pathway ²² Development Neurotrophin family signaling ²² Drug-mediated inhibition of MET activation ⁶⁶ MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ PLC-gamma1 signalling ⁶⁶ Trk receptor signaling mediated by PI3K and PLC-gamma ⁶¹ TRKA activation by NGF ⁶⁶	12.62	AKT1 CCND1 HRAS MAPK3 PTEN RAF1
47	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ⁶¹	12.61	TP53 RAF1 MYC MAPK3 KRAS HRAS
48	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.6	AKT1 EGFR HRAS KRAS TP53
49	WNT Signaling ⁶⁴	12.59	TP53 MYC MAPK3 CCND1 AKT1
50	Mitotic G1 phase and G1/S transition ⁶⁶ Show member pathways G1/S Transition ⁶⁶	12.58	MYC CDKN2A CCND1 AKT1

Sources

GO Terms for Lung Adenoma

Cellular components related to Lung Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear envelope	GO:0005635	9.28	SCGB1A1 MYC MAPK3 LMNTD1 IRAG2

Biological processes related to Lung Adenoma according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell population proliferation	GO:0008285	10.27	C18orf54 CDKN2A HRAS PTEN RAF1 TP53
2	positive regulation of cell population proliferation	GO:0008284	10.22	AKT1 CCND1 EGFR HRAS KRAS MYC
3	positive regulation of gene expression	GO:0010628	10.15	TP53 MYC MAPK3 KRAS HRAS CDKN2A
4	regulation of cell cycle	GO:0051726	10.14	TP53 PTEN HRAS CDKN2A CCND1
5	Ras protein signal transduction	GO:0007265	10.06	TP53 KRAS HRAS CDKN2A
6	MAPK cascade	GO:0000165	10.03	EGFR HRAS KRAS MAPK3 MYC RAF1
7	positive regulation of G1/S transition of mitotic cell cycle	GO:1900087	10.02	EGFR CCND1 AKT1
8	cellular response to reactive oxygen species	GO:0034614	10	MAPK3 EGFR AKT1
9	cellular response to cadmium ion	GO:0071276	9.99	MAPK3 EGFR AKT1
10	positive regulation of protein phosphorylation	GO:0001934	9.77	RAF1 MAPK3 KRAS HRAS EGFR CCND1
11	insulin-like growth factor receptor signaling pathway	GO:0048009	9.73	RAF1 MAPK3 AKT1
12	insulin receptor signaling pathway	GO:0008286	9.72	RAF1 MAPK3 HRAS AKT1
13	cellular response to decreased oxygen levels	GO:0036294	9.65	PTEN AKT1
14	response to UV-A	GO:0070141	9.63	EGFR CCND1 AKT1
15	cell population proliferation	GO:0008283	9.28	TP53 PTEN LMNTD1 KRAS EGFR CCND1