MCID: LNG030
MIFTS: 39

Lung Adenoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Adenoma

MalaCards integrated aliases for Lung Adenoma:

Name: Lung Adenoma 12 15
Adenoma of Lung 12 71
Pulmonary Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5386
NCIt 49 C4455
SNOMED-CT 67 254642004
UMLS 71 C0345964

Summaries for Lung Adenoma

Disease Ontology : 12 A lung benign neoplasm that derives from glandular epithelial cells.

MalaCards based summary : Lung Adenoma, also known as adenoma of lung, is related to appendix adenocarcinoma and skin papilloma. An important gene associated with Lung Adenoma is C18orf54 (Chromosome 18 Open Reading Frame 54), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Affiliated tissues include lung, skin and b cells, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Lung Adenoma

Diseases related to Lung Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 30.0 KRAS HRAS
2 skin papilloma 29.9 TP53 KRAS HRAS
3 squamous cell papilloma 29.9 TP53 HRAS
4 lung benign neoplasm 29.8 TP53 SCGB1A1 RARB KRAS HRAS
5 t-cell acute lymphoblastic leukemia 29.8 TP53 NOTCH3 NOTCH2 NOTCH1
6 alveoli adenoma 29.8 SCGB1A1 MIR30C1
7 in situ carcinoma 29.6 TP53 HRAS H2AC18
8 papillary adenoma 29.6 TP53 SCGB1A1 KRAS HRAS
9 skin carcinoma 29.4 TP53 MAPK1 HRAS H2AC18
10 leukemia, acute lymphoblastic 29.1 TP53 NOTCH1 KRAS HRAS H2AC18 CDK2
11 lung squamous cell carcinoma 29.1 TP53 RARB NOTCH2 NOTCH1 MAPK1 KRAS
12 lung cancer susceptibility 3 28.4 TP53 SCGB1A1 RARB RAF1 NOTCH1 MIR30C1
13 adenoma 10.7
14 nodular regenerative hyperplasia 10.5 NOTCH2 NOTCH1
15 splenic diffuse red pulp small b-cell lymphoma 10.5 TP53 NOTCH1
16 hajdu-cheney syndrome 10.5 NOTCH3 NOTCH2 NOTCH1
17 signet ring basal cell carcinoma 10.5 KRAS HRAS
18 trachea carcinoma in situ 10.5 KRAS HRAS
19 cobblestone retinal degeneration 10.5 KRAS HRAS
20 orofacial cleft 4 10.5 NOTCH1 HRAS
21 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.4 NOTCH3 NOTCH2 NOTCH1
22 alagille syndrome 1 10.4 NOTCH3 NOTCH2 NOTCH1
23 nasal cavity adenocarcinoma 10.4 KRAS HRAS
24 ossifying fibroma 10.4 NOTCH3 NOTCH1 KRAS
25 ampulla of vater neoplasm 10.4 KRAS HRAS
26 prostate squamous cell carcinoma 10.4 TP53 HRAS
27 lacrimal gland adenoid cystic carcinoma 10.4 NOTCH2 NOTCH1
28 descending colon cancer 10.4 KRAS HRAS
29 periampullary adenoma 10.4 KRAS HRAS
30 hyperplastic polyposis syndrome 10.4 TP53 KRAS
31 adenosquamous lung carcinoma 10.4 KRAS HRAS
32 acneiform dermatitis 10.4 KRAS HRAS
33 transverse colon cancer 10.4 KRAS HRAS
34 appendiceal neoplasm 10.4 KRAS HRAS
35 rare adenocarcinoma of the breast 10.4 TP53 KRAS
36 pulmonic stenosis 10.4 RAF1 KRAS HRAS
37 spitz nevus 10.3 TP53 HRAS
38 rasopathy 10.3 RAF1 KRAS HRAS
39 adams-oliver syndrome 10.3 NOTCH3 NOTCH2 NOTCH1
40 ras-associated autoimmune leukoproliferative disorder 10.3 KRAS HRAS ALDH1A1
41 noonan syndrome 3 10.3 RAF1 KRAS HRAS
42 myh-associated polyposis 10.3 KRAS HRAS
43 adult teratoma 10.3 TP53 HRAS
44 mucinous lung adenocarcinoma 10.3 KRAS HRAS
45 noonan syndrome with multiple lentigines 10.3 RAF1 KRAS HRAS
46 basal cell nevus syndrome 10.3 TP53 NOTCH2 NOTCH1
47 ovarian serous carcinoma 10.3 TP53 NOTCH3 KRAS
48 endometrial serous adenocarcinoma 10.3 TP53 KRAS CCNE1
49 gallbladder benign neoplasm 10.3 TP53 KRAS HRAS
50 wolffian duct adenocarcinoma 10.3 TP53 KRAS HRAS

Graphical network of the top 20 diseases related to Lung Adenoma:



Diseases related to Lung Adenoma

Symptoms & Phenotypes for Lung Adenoma

MGI Mouse Phenotypes related to Lung Adenoma:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 ALDH1A1 CCNE1 CDK2 KRAS MAPK1 NOTCH1
2 endocrine/exocrine gland MP:0005379 10.36 ALDH1A1 CCNE1 CDK2 HRAS KRAS MAPK1
3 growth/size/body region MP:0005378 10.35 ALDH1A1 CCNE1 CDK2 HRAS KRAS MAPK1
4 cardiovascular system MP:0005385 10.33 CCNE1 CDK2 HRAS KRAS MAPK1 NOTCH1
5 embryo MP:0005380 10.3 ALDH1A1 CCNE1 CDK2 KRAS MAPK1 NOTCH1
6 hematopoietic system MP:0005397 10.25 CCNE1 CDK2 KRAS MAPK1 NOTCH1 NOTCH2
7 mortality/aging MP:0010768 10.25 ALDH1A1 CCNE1 CDK2 HRAS KRAS MAPK1
8 immune system MP:0005387 10.24 CCNE1 CDK2 KRAS MAPK1 NOTCH1 NOTCH2
9 craniofacial MP:0005382 10.23 ALDH1A1 HRAS KRAS MAPK1 NOTCH1 NOTCH2
10 integument MP:0010771 10.22 CCNE1 CDK2 HRAS IRAG2 KRAS MAPK1
11 digestive/alimentary MP:0005381 10.17 CCNE1 HRAS KRAS MAPK1 NOTCH1 NOTCH2
12 neoplasm MP:0002006 10.15 CCNE1 CDK2 CFAP94 HRAS KRAS MAPK1
13 hearing/vestibular/ear MP:0005377 10.07 KRAS MAPK1 NOTCH1 NOTCH3 RAF1 RARB
14 liver/biliary system MP:0005370 10.06 ALDH1A1 CDK2 KRAS MAPK1 NOTCH1 NOTCH2
15 muscle MP:0005369 10.06 CDK2 KRAS MAPK1 NOTCH1 NOTCH2 NOTCH3
16 normal MP:0002873 10.06 ALDH1A1 CCNE1 HRAS KRAS NOTCH1 NOTCH2
17 respiratory system MP:0005388 9.9 ALDH1A1 HRAS KRAS MAPK1 NOTCH1 NOTCH2
18 renal/urinary system MP:0005367 9.86 HRAS KRAS NOTCH1 NOTCH2 NOTCH3 RARB
19 skeleton MP:0005390 9.65 CCNE1 HRAS KRAS MAPK1 NOTCH1 NOTCH2
20 vision/eye MP:0005391 9.32 ALDH1A1 CDK2 KRAS MAPK1 NOTCH1 NOTCH2

Drugs & Therapeutics for Lung Adenoma

Search Clinical Trials , NIH Clinical Center for Lung Adenoma

Genetic Tests for Lung Adenoma

Anatomical Context for Lung Adenoma

MalaCards organs/tissues related to Lung Adenoma:

40
Lung, Skin, B Cells, Brain, Liver, Breast, Testes

Publications for Lung Adenoma

Articles related to Lung Adenoma:

(show top 50) (show all 175)
# Title Authors PMID Year
1
Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice. 61
32476407 2020
2
Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells. 61
32209656 2020
3
Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer. 61
31811110 2019
4
Toxicological evaluation of carcinogenicity of the pyrethroid imiprothrin in rats and mice. 61
30905765 2019
5
Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice. 61
30873838 2019
6
Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. 61
29572547 2019
7
CD44 facilitates adherence of Streptococcus equi subsp. zooepidemicus to LA-4 cells. 61
30639625 2019
8
Effects of talactoferrin alpha on lung adenoma prevention in A/J mice June 2, 2016. 61
29636877 2018
9
The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model. 61
28851689 2017
10
p53 loss does not permit escape from BrafV600E-induced senescence in a mouse model of lung cancer. 61
28745322 2017
11
Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis. 61
29191600 2017
12
The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation. 61
28811474 2017
13
An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. 61
28431163 2017
14
Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance. 61
28260069 2017
15
A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis. 61
28253859 2017
16
Safety and Preclinical Efficacy of Aerosol Pioglitazone on Lung Adenoma Prevention in A/J Mice. 61
27993834 2017
17
Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention. 61
28052934 2017
18
[Metastatic pleomorphic adenoma of lung: report of a case]. 61
28072982 2017
19
Changes of serum amino acid profiles by an epidermal growth factor receptor mutation and benzo[a]pyrene in mouse lung tumorigenesis. 61
30090424 2016
20
Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. 61
27210750 2016
21
Uridine homeostatic disorder leads to DNA damage and tumorigenesis. 61
26801745 2016
22
Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway. 61
26472723 2016
23
How do K-RAS-activated cells evade cellular defense mechanisms? 61
25961920 2016
24
Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice. 61
27293987 2016
25
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice. 61
26397133 2015
26
Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. 61
26030593 2015
27
Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses. 61
25005685 2014
28
Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells. 61
24959744 2014
29
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. 61
24403291 2014
30
ALDH maintains the stemness of lung adenoma stem cells by suppressing the Notch/CDK2/CCNE pathway. 61
24671051 2014
31
Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice. 61
24106881 2013
32
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells. 61
23963803 2013
33
Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. 61
24027427 2013
34
Xiao-Qing-Long-Tang shows preventive effect of asthma in an allergic asthma mouse model through neurotrophin regulation. 61
24010817 2013
35
Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas. 61
23825589 2013
36
Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice. 61
23304102 2012
37
Deletions in the neuraminidase stalk region of H2N2 and H9N2 avian influenza virus subtypes do not affect postinfluenza secondary bacterial pneumonia. 61
22278240 2012
38
Senescence and pre-malignancy: how do tumors progress? 61
21982725 2011
39
Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration. 61
21562034 2011
40
High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice. 61
21221514 2011
41
Synergism between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumor incidence in mice. 61
21167638 2011
42
An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. 61
22754076 2011
43
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. 61
21721153 2011
44
Low dosage 5-fluorouracil increases the transfection efficiency of Ad/VEGF-A in mouse lung carcinoma cell line LA795 and inhibits tumor growth. 61
20591220 2010
45
Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. 61
19625346 2010
46
Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. 61
19716299 2009
47
Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. 61
19622765 2009
48
8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. 61
21475870 2009
49
IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding. 61
19420136 2009
50
FTY720 and lung tumor development. 61
19146992 2009

Variations for Lung Adenoma

Expression for Lung Adenoma

Search GEO for disease gene expression data for Lung Adenoma.

Pathways for Lung Adenoma

Pathways related to Lung Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.27 TP53 RARB RAF1 NOTCH3 NOTCH2 NOTCH1
2
Show member pathways
13.87 TP53 RARB RAF1 NOTCH3 NOTCH2 NOTCH1
3
Show member pathways
13.13 TP53 RAF1 MAPK1 KRAS HRAS CDK2
4
Show member pathways
12.99 RAF1 MAPK1 KRAS HRAS CDK2 CCNE1
5
Show member pathways
12.97 TP53 RAF1 NOTCH3 NOTCH2 NOTCH1 MAPK1
6
Show member pathways
12.91 TP53 RAF1 MAPK1 KRAS HRAS CDK2
7
Show member pathways
12.89 TP53 RAF1 MAPK1 CDK2 CCNE1
8 12.85 TP53 RAF1 MAPK1 KRAS HRAS
9
Show member pathways
12.8 TP53 RAF1 MAPK1 KRAS HRAS
10
Show member pathways
12.79 TP53 RAF1 MAPK1 KRAS HRAS
11 12.79 TP53 RARB RAF1 NOTCH3 NOTCH2 NOTCH1
12
Show member pathways
12.76 MAPK1 KRAS HRAS CDK2 CCNE1
13
Show member pathways
12.76 TP53 RAF1 MAPK1 KRAS HRAS
14
Show member pathways
12.71 TP53 RAF1 MAPK1 KRAS HRAS
15
Show member pathways
12.6 TP53 RAF1 MAPK1 KRAS HRAS
16
Show member pathways
12.6 TP53 RAF1 MAPK1 KRAS HRAS
17
Show member pathways
12.52 RAF1 MAPK1 KRAS HRAS
18
Show member pathways
12.49 RAF1 MAPK1 KRAS HRAS
19
Show member pathways
12.48 RAF1 MAPK1 KRAS HRAS
20
Show member pathways
12.48 RAF1 MAPK1 KRAS HRAS
21
Show member pathways
12.47 RAF1 MAPK1 KRAS HRAS
22
Show member pathways
12.47 TP53 RAF1 MAPK1 HRAS
23
Show member pathways
12.44 RAF1 MAPK1 KRAS CDK2 CCNE1
24
Show member pathways
12.43 TP53 RAF1 CDK2 CCNE1
25
Show member pathways
12.43 TP53 H2AC18 CDK2 CCNE1
26
Show member pathways
12.42 RAF1 MAPK1 KRAS HRAS
27
Show member pathways
12.41 RAF1 MAPK1 KRAS HRAS
28
Show member pathways
12.4 TP53 RAF1 MAPK1 HRAS
29
Show member pathways
12.39 TP53 RAF1 MAPK1 HRAS
30
Show member pathways
12.38 RAF1 MAPK1 KRAS HRAS
31 12.38 TP53 RAF1 MAPK1 KRAS HRAS
32 12.38 TP53 MAPK1 KRAS HRAS CDK2 CCNE1
33
Show member pathways
12.36 TP53 RARB RAF1 NOTCH3 NOTCH2 NOTCH1
34 12.35 TP53 RAF1 NOTCH3 NOTCH2 NOTCH1 MIR30C1
35
Show member pathways
12.34 TP53 MAPK1 CDK2 CCNE1
36 12.33 RAF1 MAPK1 KRAS HRAS
37 12.33 TP53 MAPK1 KRAS HRAS CDK2 CCNE1
38
Show member pathways
12.33 TP53 RAF1 MAPK1 KRAS HRAS CDK2
39
Show member pathways
12.31 RAF1 MAPK1 KRAS HRAS
40
Show member pathways
12.29 RAF1 MAPK1 KRAS HRAS
41 12.28 RAF1 MAPK1 KRAS HRAS
42
Show member pathways
12.28 TP53 RAF1 MAPK1 KRAS HRAS CDK2
43
Show member pathways
12.27 TP53 RAF1 KRAS HRAS
44 12.24 TP53 MAPK1 KRAS CDK2
45
Show member pathways
12.23 RAF1 MAPK1 KRAS HRAS
46 12.2 RAF1 MAPK1 KRAS HRAS
47
Show member pathways
12.19 TP53 RAF1 MAPK1 KRAS HRAS
48 12.18 RAF1 MAPK1 KRAS HRAS
49
Show member pathways
12.18 RAF1 MAPK1 KRAS HRAS
50
Show member pathways
12.17 TP53 MAPK1 KRAS HRAS

GO Terms for Lung Adenoma

Cellular components related to Lung Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin E1-CDK2 complex GO:0097134 8.62 CDK2 CCNE1

Biological processes related to Lung Adenoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 TP53 NOTCH1 MAPK1 KRAS HRAS
2 positive regulation of cell proliferation GO:0008284 9.95 NOTCH2 NOTCH1 MAPK1 KRAS HRAS CDK2
3 MAPK cascade GO:0000165 9.91 RAF1 MAPK1 KRAS HRAS
4 heart development GO:0007507 9.89 TP53 RAF1 NOTCH1 MAPK1
5 axon guidance GO:0007411 9.87 NOTCH3 NOTCH2 NOTCH1 MAPK1
6 negative regulation of cell proliferation GO:0008285 9.85 TP53 RARB RAF1 NOTCH1 HRAS C18orf54
7 transcription initiation from RNA polymerase II promoter GO:0006367 9.81 RARB NOTCH3 NOTCH2 NOTCH1
8 cell cycle arrest GO:0007050 9.8 TP53 NOTCH2 NOTCH1 HRAS
9 multicellular organism growth GO:0035264 9.77 TP53 RARB NOTCH2
10 negative regulation of transcription by RNA polymerase II GO:0000122 9.76 TP53 SCGB1A1 RARB NOTCH3 NOTCH2 NOTCH1
11 Ras protein signal transduction GO:0007265 9.62 TP53 KRAS HRAS CDK2
12 Notch signaling involved in heart development GO:0061314 9.58 NOTCH2 NOTCH1
13 positive regulation of Ras protein signal transduction GO:0046579 9.58 NOTCH2 NOTCH1 HRAS
14 mitotic G1 DNA damage checkpoint GO:0031571 9.56 TP53 CDK2
15 negative regulation of cell differentiation GO:0045596 9.56 NOTCH3 NOTCH1 MAPK1 KRAS
16 interleukin-4 secretion GO:0072602 9.55 NOTCH2 NOTCH1
17 response to isolation stress GO:0035900 9.54 KRAS HRAS
18 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.52 TP53 NOTCH1
19 glomerular capillary formation GO:0072104 9.46 NOTCH3 NOTCH2
20 negative regulation of growth rate GO:0045967 9.43 NOTCH2 NOTCH1
21 liver development GO:0001889 9.35 RARB NOTCH2 NOTCH1 KRAS HRAS
22 regulation of developmental process GO:0050793 8.8 NOTCH3 NOTCH2 NOTCH1

Molecular functions related to Lung Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.26 RARB NOTCH3 NOTCH2 NOTCH1
2 enzyme binding GO:0019899 9.02 TP53 RAF1 NOTCH3 NOTCH2 NOTCH1

Sources for Lung Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....