MCID: LNG030
MIFTS: 31

Lung Adenoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Adenoma

MalaCards integrated aliases for Lung Adenoma:

Name: Lung Adenoma 12 15
Adenoma of Lung 12 74
Pulmonary Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5386
NCIt 51 C4455
UMLS 74 C0345964

Summaries for Lung Adenoma

Disease Ontology : 12 A lung benign neoplasm that derives from glandular epithelial cells.

MalaCards based summary : Lung Adenoma, also known as adenoma of lung, is related to adenoma and papilloma. An important gene associated with Lung Adenoma is C18orf54 (Chromosome 18 Open Reading Frame 54), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. Affiliated tissues include lung and skin, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Lung Adenoma

Diseases related to Lung Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenoma 10.5
2 papilloma 9.7
3 adenocarcinoma 9.7
4 skin papilloma 9.7

Symptoms & Phenotypes for Lung Adenoma

GenomeRNAi Phenotypes related to Lung Adenoma according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 MAPK1
2 Decreased viability GR00221-A-1 9.47 MAPK1 RAF1
3 Decreased viability GR00221-A-2 9.47 RAF1
4 Decreased viability GR00221-A-3 9.47 MAPK1
5 Decreased viability GR00221-A-4 9.47 MAPK1
6 Decreased viability GR00231-A 9.47 MAPK1 RAF1
7 Decreased viability GR00301-A 9.47 RAF1
8 Decreased viability GR00342-S-1 9.47 MAPK1
9 Decreased viability GR00342-S-2 9.47 MAPK1
10 Decreased viability GR00342-S-3 9.47 MAPK1
11 Decreased viability GR00402-S-2 9.47 MAPK1 RAF1

MGI Mouse Phenotypes related to Lung Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.73 ALDH1A1 CCNE1 MAPK1 NOTCH2 RAF1 RARB
2 craniofacial MP:0005382 9.72 ALDH1A1 MAPK1 NOTCH2 RAF1 RARB
3 endocrine/exocrine gland MP:0005379 9.63 ALDH1A1 CCNE1 MAPK1 NOTCH2 RAF1 RARB
4 respiratory system MP:0005388 9.35 ALDH1A1 MAPK1 NOTCH2 RAF1 RARB
5 vision/eye MP:0005391 9.02 ALDH1A1 MAPK1 NOTCH2 RAF1 RARB

Drugs & Therapeutics for Lung Adenoma

Search Clinical Trials , NIH Clinical Center for Lung Adenoma

Genetic Tests for Lung Adenoma

Anatomical Context for Lung Adenoma

MalaCards organs/tissues related to Lung Adenoma:

42
Lung, Skin

Publications for Lung Adenoma

Articles related to Lung Adenoma:

(show all 41)
# Title Authors Year
1
Effects of talactoferrin alpha on lung adenoma prevention in A/J mice June 2, 2016. ( 29636877 )
2018
2
Safety and Preclinical Efficacy of Aerosol Pioglitazone on Lung Adenoma Prevention in A/J Mice. ( 27993834 )
2016
3
Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice. ( 27293987 )
2016
4
Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. ( 26030593 )
2015
5
Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway. ( 26472723 )
2015
6
Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice. ( 23304102 )
2012
7
Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. ( 17363568 )
2007
8
Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. ( 17974961 )
2007
9
beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model. ( 16898870 )
2006
10
The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model. ( 16632869 )
2006
11
Phenotypic characteristics of mouse lung adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. ( 15584020 )
2005
12
Inhibition of benzo(a)pyrene induced lung adenoma by panax ginseng extract, EFLA400, in Swiss albino mice. ( 16272690 )
2005
13
Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice. ( 15703070 )
2005
14
Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure. ( 15171791 )
2004
15
Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch. ( 12727849 )
2003
16
Indomethacin reduces lung adenoma number in A/J mice. ( 11497255 )
2001
17
The effect of exposure to a commercial 2,4-D herbicide formulation during gestation on urethan-induced lung adenoma formation in CD-1 mice. ( 10839313 )
2000
18
Thymosinalpha1 is chemopreventive for lung adenoma formation in A/J mice. ( 10822126 )
2000
19
Lung adenoma development and NK activity in mice treated with multiple carcinogens. ( 1418756 )
1992
20
The effects of Tordon 202c exposure on urethan-induced lung adenoma formation in female CD-1 mice. ( 1858296 )
1991
21
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens. ( 1771369 )
1991
22
Lung adenoma structure among inbred strains of mice: the pulmonary adenoma histologic type (Pah) genes. ( 1764694 )
1991
23
Enhanced malignant phenotype of urethane-induced lung adenoma associated with sialoadenectomy in BALB/c mice. ( 2786772 )
1989
24
Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay. ( 3365834 )
1988
25
Malignant epithelial cell strains cultured from BALB/c mouse lung adenoma. ( 3829131 )
1987
26
Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethan and benzo(a)pyrene. ( 3480057 )
1987
27
Comparison of two routes of chemical administration on the lung adenoma response in strain A/J mice. ( 3945940 )
1986
28
A combined carcinogen bioassay utilizing both the lung adenoma and skin papilloma protocols. ( 3780626 )
1986
29
A comparison of the lung adenoma response in strain A/J mice after intraperitoneal and oral administration of carcinogens. ( 6695378 )
1984
30
Bacterial and mammalian cell mutagenesis, sister-chromatid exchange, and mouse lung adenoma bioassay with the antineoplastic acridine derivative amsacrine. ( 6394768 )
1984
31
Pharmacologic and genetic studies on the modulatory effects of butylated hydroxytoluene on mouse lung adenoma formation. ( 6592388 )
1984
32
Establishment of epithelial cell strains from normal adult mouse lung resembling a urethane-induced lung adenoma cell strain and a metastasizing mouse lung carcinoma cell line. ( 6713549 )
1984
33
Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay. ( 6488452 )
1984
34
Effect of 12-O-tetradecanoylphorbol-13-acetate on polyamine metabolism in mice sensitive and resistant to lung-adenoma. ( 6616764 )
1983
35
Relationship of lung adenoma prevalence and growth rate to acute urethan dose and target cell number. ( 6956762 )
1982
36
Inflammatory pseudotumor and lung adenoma. ( 100292 )
1978
37
Lecithin biosynthesis in a clonal line of lung adenoma cells with type II alveolar cell properties. ( 581072 )
1978
38
Clonal isolation of epithelial cells from mouse lung adenoma. ( 167947 )
1975
39
Enhancement of lung adenoma formation by neonatal thymectomy in mice treated with 7,12-dimethylbenz(a)anthracene or urethan. ( 6055972 )
1967
40
Urethan carcinogenesis and nucleic acid metabolism: factors influencing lung adenoma induction. ( 5921493 )
1966
41
Mammary tumor inhibition and lung adenoma induction by isonicotinic acid hydrazide. ( 5937130 )
1966

Variations for Lung Adenoma

Expression for Lung Adenoma

Search GEO for disease gene expression data for Lung Adenoma.

Pathways for Lung Adenoma

Pathways related to Lung Adenoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 CCNE1 MAPK1 NOTCH2 RAF1
2 12.28 CCNE1 MAPK1 NOTCH2 RAF1 RARB
3 12.18 CCNE1 MAPK1 NOTCH2 RAF1
4
Show member pathways
12.14 CCNE1 MAPK1 RAF1
5
Show member pathways
11.95 CCNE1 MAPK1 NOTCH2 RAF1 RARB
6 11.94 CCNE1 MAPK1 RAF1
7 11.72 MAPK1 NOTCH2 RAF1
8
Show member pathways
11.69 CCNE1 MAPK1 NOTCH2 RAF1 RARB
9 11.68 CCNE1 MAPK1 RAF1
10 11.38 MAPK1 RAF1
11
Show member pathways
11.38 CCNE1 MAPK1 RAF1
12 11.38 CCNE1 MAPK1 RAF1
13 11.34 MAPK1 RAF1
14 11.29 MAPK1 RAF1
15 11.29 MAPK1 RAF1
16 11.29 MAPK1 RAF1
17 11.28 CCNE1 MAPK1 RAF1
18 11.27 MAPK1 RAF1
19 11.16 MAPK1 RAF1
20 11.16 MAPK1 RAF1
21 11.14 MAPK1 RAF1
22
Show member pathways
11.1 MAPK1 RAF1
23
Show member pathways
11.08 MAPK1 RAF1
24 11.08 ALDH1A1 MAPK1 RARB
25 11.04 MAPK1 RAF1
26 11.02 MAPK1 RAF1
27 10.94 CCNE1 MAPK1
28 10.87 MAPK1 RAF1
29 10.8 MAPK1 RAF1
30 10.79 MAPK1 RAF1
31 10.67 MAPK1 RAF1
32 10.57 MAPK1 RAF1
33 10.28 MAPK1 RAF1

GO Terms for Lung Adenoma

Cellular components related to Lung Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pseudopodium GO:0031143 8.62 MAPK1 RAF1

Biological processes related to Lung Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thymus development GO:0048538 9.16 MAPK1 RAF1
2 thyroid gland development GO:0030878 8.96 MAPK1 RAF1
3 face development GO:0060324 8.62 MAPK1 RAF1

Sources for Lung Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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