MCID: LNG030
MIFTS: 37

Lung Adenoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Adenoma

MalaCards integrated aliases for Lung Adenoma:

Name: Lung Adenoma 12 15
Adenoma of Lung 12 70
Pulmonary Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5386
NCIt 50 C4455
SNOMED-CT 67 254642004
UMLS 70 C0345964

Summaries for Lung Adenoma

Disease Ontology : 12 A lung benign neoplasm that derives from glandular epithelial cells.

MalaCards based summary : Lung Adenoma, also known as adenoma of lung, is related to squamous cell papilloma and skin papilloma. An important gene associated with Lung Adenoma is C18orf54 (Chromosome 18 Open Reading Frame 54), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Affiliated tissues include lung, skin and colon, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Lung Adenoma

Diseases related to Lung Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 30.0 TP53 HRAS
2 skin papilloma 29.9 TP53 KRAS HRAS
3 lung squamous cell carcinoma 29.6 TP53 RARB NOTCH1 KRAS HRAS
4 lung benign neoplasm 29.5 TP53 SFTPC SCGB1A1 RARB KRAS HRAS
5 lung cancer susceptibility 3 28.9 TP53 SFTPC SCGB1A1 RAF1 KRAS HRAS
6 nodular regenerative hyperplasia 10.4 NOTCH2 NOTCH1
7 hepatic flexure cancer 10.4 KRAS HRAS
8 hajdu-cheney syndrome 10.4 NOTCH3 NOTCH2 NOTCH1
9 trachea carcinoma in situ 10.4 KRAS HRAS
10 signet ring basal cell carcinoma 10.4 KRAS HRAS
11 cobblestone retinal degeneration 10.4 KRAS HRAS
12 immature teratoma of ovary 10.3 KRAS HRAS
13 splenic diffuse red pulp small b-cell lymphoma 10.3 TP53 NOTCH1
14 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.3 NOTCH3 NOTCH2 NOTCH1
15 lacrimal gland adenoid cystic carcinoma 10.3 NOTCH2 NOTCH1
16 descending colon cancer 10.3 KRAS HRAS
17 ampulla of vater benign neoplasm 10.3 KRAS HRAS
18 alagille syndrome 1 10.3 NOTCH3 NOTCH2 NOTCH1
19 ossifying fibroma 10.3 NOTCH3 NOTCH1 KRAS
20 transverse colon cancer 10.3 KRAS HRAS
21 periampullary adenoma 10.3 KRAS HRAS
22 acneiform dermatitis 10.3 KRAS HRAS
23 appendiceal neoplasm 10.3 KRAS HRAS
24 gallbladder benign neoplasm 10.3 KRAS HRAS
25 adenosquamous lung carcinoma 10.3 KRAS HRAS
26 appendix adenocarcinoma 10.3 KRAS HRAS
27 mucinous lung adenocarcinoma 10.3 KRAS HRAS
28 wolffian duct adenocarcinoma 10.3 KRAS HRAS
29 intrahepatic bile duct adenoma 10.3 TP53 NOTCH3 NOTCH2
30 noonan syndrome 3 10.3 RAF1 KRAS HRAS
31 spitz nevus 10.3 TP53 HRAS
32 ras-associated autoimmune leukoproliferative disorder 10.3 KRAS HRAS ALDH1A1
33 melanoma in congenital melanocytic nevus 10.2 RAF1 HRAS H2AC18
34 noonan syndrome-like disorder with loose anagen hair 1 10.2 KRAS HRAS
35 noonan syndrome with multiple lentigines 10.2 RAF1 KRAS HRAS
36 cardiofaciocutaneous syndrome 1 10.2 RAF1 KRAS HRAS
37 bronchiolo-alveolar adenocarcinoma 10.2 MIR30C1 KRAS HRAS
38 endometrial serous adenocarcinoma 10.2 TP53 KRAS CCNE1
39 ovarian serous carcinoma 10.2 TP53 NOTCH3 KRAS
40 adenoma 10.2
41 prostate squamous cell carcinoma 10.2 TP53 HRAS CCNE1
42 tonsil cancer 10.2 TP53 NOTCH1 H2AC18
43 liver angiosarcoma 10.2 TP53 KRAS
44 pancreatic signet ring cell adenocarcinoma 10.2 TP53 KRAS HRAS
45 signet ring cell adenocarcinoma 10.2 TP53 KRAS HRAS
46 skin squamous cell carcinoma 10.2 TP53 RAF1 HRAS
47 bone giant cell sarcoma 10.2 TP53 KRAS HRAS
48 myxofibrosarcoma 10.2 TP53 KRAS ALDH1A1
49 myh-associated polyposis 10.2 KRAS HRAS
50 biliary tract benign neoplasm 10.2 TP53 KRAS HRAS

Graphical network of the top 20 diseases related to Lung Adenoma:



Diseases related to Lung Adenoma

Symptoms & Phenotypes for Lung Adenoma

MGI Mouse Phenotypes related to Lung Adenoma:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.27 ALDH1A1 CCNE1 CDK2 HRAS KRAS NOTCH1
2 cardiovascular system MP:0005385 10.26 CCNE1 CDK2 HRAS KRAS NOTCH1 NOTCH2
3 endocrine/exocrine gland MP:0005379 10.26 ALDH1A1 CCNE1 CDK2 HRAS KRAS NOTCH1
4 embryo MP:0005380 10.19 ALDH1A1 CCNE1 CDK2 KRAS NOTCH1 NOTCH2
5 integument MP:0010771 10.13 CCNE1 CDK2 HRAS IRAG2 KRAS NOTCH1
6 craniofacial MP:0005382 10.11 ALDH1A1 HRAS KRAS NOTCH1 NOTCH2 RAF1
7 neoplasm MP:0002006 10.1 CCNE1 CDK2 DNAI7 HRAS KRAS NOTCH1
8 muscle MP:0005369 10.02 CDK2 HRAS KRAS NOTCH1 NOTCH2 NOTCH3
9 liver/biliary system MP:0005370 10.01 ALDH1A1 CDK2 KRAS NOTCH1 NOTCH2 NOTCH3
10 normal MP:0002873 10 ALDH1A1 CCNE1 HRAS KRAS NOTCH1 NOTCH2
11 renal/urinary system MP:0005367 9.76 HRAS KRAS NOTCH1 NOTCH2 NOTCH3 RARB
12 respiratory system MP:0005388 9.7 ALDH1A1 HRAS KRAS NOTCH1 NOTCH2 NOTCH3
13 vision/eye MP:0005391 9.32 ALDH1A1 CDK2 KRAS NOTCH1 NOTCH2 NOTCH3

Drugs & Therapeutics for Lung Adenoma

Search Clinical Trials , NIH Clinical Center for Lung Adenoma

Genetic Tests for Lung Adenoma

Anatomical Context for Lung Adenoma

MalaCards organs/tissues related to Lung Adenoma:

40
Lung, Skin, Colon, Ovary, Appendix, Bone, Pancreas

Publications for Lung Adenoma

Articles related to Lung Adenoma:

(show top 50) (show all 176)
# Title Authors PMID Year
1
Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung. 61
33629582 2021
2
Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice. 61
32476407 2020
3
Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells. 61
32209656 2020
4
Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer. 61
31811110 2019
5
Toxicological evaluation of carcinogenicity of the pyrethroid imiprothrin in rats and mice. 61
30905765 2019
6
Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice. 61
30873838 2019
7
Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. 61
29572547 2019
8
CD44 facilitates adherence of Streptococcus equi subsp. zooepidemicus to LA-4 cells. 61
30639625 2019
9
Effects of talactoferrin alpha on lung adenoma prevention in A/J mice June 2, 2016. 61
29636877 2018
10
The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model. 61
28851689 2017
11
p53 loss does not permit escape from BrafV600E-induced senescence in a mouse model of lung cancer. 61
28745322 2017
12
Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis. 61
29191600 2017
13
The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation. 61
28811474 2017
14
An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. 61
28431163 2017
15
Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance. 61
28260069 2017
16
A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis. 61
28253859 2017
17
Safety and Preclinical Efficacy of Aerosol Pioglitazone on Lung Adenoma Prevention in A/J Mice. 61
27993834 2017
18
Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention. 61
28052934 2017
19
[Metastatic pleomorphic adenoma of lung: report of a case]. 61
28072982 2017
20
Changes of serum amino acid profiles by an epidermal growth factor receptor mutation and benzo[a]pyrene in mouse lung tumorigenesis. 61
30090424 2016
21
Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. 61
27210750 2016
22
Uridine homeostatic disorder leads to DNA damage and tumorigenesis. 61
26801745 2016
23
Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway. 61
26472723 2016
24
How do K-RAS-activated cells evade cellular defense mechanisms? 61
25961920 2016
25
Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice. 61
27293987 2016
26
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice. 61
26397133 2015
27
Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. 61
26030593 2015
28
Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses. 61
25005685 2014
29
Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells. 61
24959744 2014
30
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. 61
24403291 2014
31
ALDH maintains the stemness of lung adenoma stem cells by suppressing the Notch/CDK2/CCNE pathway. 61
24671051 2014
32
Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice. 61
24106881 2013
33
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells. 61
23963803 2013
34
Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. 61
24027427 2013
35
Xiao-Qing-Long-Tang shows preventive effect of asthma in an allergic asthma mouse model through neurotrophin regulation. 61
24010817 2013
36
Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas. 61
23825589 2013
37
Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice. 61
23304102 2012
38
Deletions in the neuraminidase stalk region of H2N2 and H9N2 avian influenza virus subtypes do not affect postinfluenza secondary bacterial pneumonia. 61
22278240 2012
39
Senescence and pre-malignancy: how do tumors progress? 61
21982725 2011
40
Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration. 61
21562034 2011
41
High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice. 61
21221514 2011
42
Synergism between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumor incidence in mice. 61
21167638 2011
43
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. 61
21721153 2011
44
An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. 61
22754076 2011
45
Low dosage 5-fluorouracil increases the transfection efficiency of Ad/VEGF-A in mouse lung carcinoma cell line LA795 and inhibits tumor growth. 61
20591220 2010
46
Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. 61
19625346 2010
47
Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. 61
19716299 2009
48
Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. 61
19622765 2009
49
8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. 61
21475870 2009
50
IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding. 61
19420136 2009

Variations for Lung Adenoma

Expression for Lung Adenoma

Search GEO for disease gene expression data for Lung Adenoma.

Pathways for Lung Adenoma

Pathways related to Lung Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.21 TP53 RARB RAF1 NOTCH3 NOTCH2 NOTCH1
2
Show member pathways
13.82 TP53 RARB RAF1 NOTCH3 NOTCH2 NOTCH1
3
Show member pathways
12.89 TP53 RAF1 NOTCH3 NOTCH2 NOTCH1 KRAS
4
Show member pathways
12.78 TP53 RAF1 KRAS HRAS CDK2 CCNE1
5 12.68 TP53 RARB RAF1 NOTCH3 NOTCH2 NOTCH1
6
Show member pathways
12.38 RAF1 KRAS CDK2 CCNE1
7
Show member pathways
12.37 TP53 RAF1 CDK2 CCNE1
8
Show member pathways
12.37 TP53 H2AC18 CDK2 CCNE1
9
Show member pathways
12.36 TP53 RAF1 KRAS HRAS
10 12.32 TP53 RAF1 KRAS HRAS
11
Show member pathways
12.32 TP53 RARB RAF1 NOTCH3 NOTCH2 NOTCH1
12 12.31 TP53 KRAS HRAS CDK2 CCNE1
13 12.3 TP53 RAF1 NOTCH3 NOTCH2 NOTCH1 MIR30C1
14 12.26 TP53 KRAS HRAS CDK2 CCNE1
15
Show member pathways
12.24 TP53 RAF1 KRAS HRAS CDK2
16
Show member pathways
12.21 TP53 RAF1 KRAS HRAS CDK2
17
Show member pathways
12.19 TP53 RAF1 KRAS HRAS
18
Show member pathways
12.16 TP53 RAF1 KRAS HRAS
19
Show member pathways
12.1 RAF1 KRAS HRAS CDK2
20 12.1 RAF1 NOTCH3 KRAS HRAS
21 12.1 TP53 RAF1 KRAS HRAS CDK2 CCNE1
22
Show member pathways
12.08 RAF1 KRAS HRAS CDK2
23
Show member pathways
12.06 KRAS HRAS CDK2 CCNE1
24
Show member pathways
12.04 TP53 NOTCH3 NOTCH2 NOTCH1
25 12.01 TP53 RAF1 KRAS HRAS
26 11.95 TP53 RAF1 NOTCH3 NOTCH2 NOTCH1 KRAS
27
Show member pathways
11.92 TP53 RARB RAF1 NOTCH3 NOTCH2 NOTCH1
28 11.89 TP53 RAF1 KRAS HRAS CDK2 CCNE1
29 11.86 NOTCH3 NOTCH2 NOTCH1
30 11.86 TP53 RARB CDK2 CCNE1
31 11.85 RAF1 KRAS HRAS
32
Show member pathways
11.84 TP53 CDK2 CCNE1
33 11.83 TP53 RAF1 CDK2 CCNE1
34
Show member pathways
11.82 RAF1 KRAS HRAS
35 11.8 TP53 RAF1 KRAS
36 11.75 RAF1 KRAS HRAS
37 11.73 RAF1 KRAS HRAS
38 11.73 RAF1 KRAS HRAS
39 11.72 TP53 KRAS HRAS
40 11.71 RAF1 KRAS HRAS
41 11.7 TP53 RAF1 KRAS HRAS
42
Show member pathways
11.69 RAF1 KRAS HRAS
43 11.68 RAF1 KRAS HRAS
44 11.67 TP53 RAF1 KRAS HRAS
45 11.65 RAF1 CDK2 CCNE1
46 11.65 RAF1 KRAS HRAS
47 11.64 RAF1 HRAS CDK2 CCNE1
48 11.62 RAF1 CDK2 CCNE1
49
Show member pathways
11.61 RAF1 KRAS HRAS
50 11.6 TP53 RAF1 NOTCH1 HRAS

GO Terms for Lung Adenoma

Cellular components related to Lung Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin E1-CDK2 complex GO:0097134 8.62 CDK2 CCNE1

Biological processes related to Lung Adenoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.96 NOTCH2 NOTCH1 KRAS HRAS CDK2
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.95 TP53 SCGB1A1 RARB NOTCH2 NOTCH1 CDK2
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.76 RARB NOTCH3 NOTCH2 NOTCH1
4 cell cycle arrest GO:0007050 9.73 TP53 NOTCH2 NOTCH1 HRAS
5 negative regulation of cell proliferation GO:0008285 9.73 TP53 RARB RAF1 NOTCH1 HRAS C18orf54
6 multicellular organism growth GO:0035264 9.7 TP53 RARB NOTCH2
7 left/right axis specification GO:0070986 9.55 NOTCH2 NOTCH1
8 Notch signaling involved in heart development GO:0061314 9.54 NOTCH2 NOTCH1
9 mitotic G1 DNA damage checkpoint GO:0031571 9.51 TP53 CDK2
10 positive regulation of Ras protein signal transduction GO:0046579 9.5 NOTCH2 NOTCH1 HRAS
11 response to isolation stress GO:0035900 9.49 KRAS HRAS
12 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.48 TP53 NOTCH1
13 liver development GO:0001889 9.46 NOTCH2 NOTCH1 KRAS HRAS
14 negative regulation of growth rate GO:0045967 9.37 NOTCH2 NOTCH1
15 Ras protein signal transduction GO:0007265 9.26 TP53 KRAS HRAS CDK2
16 regulation of developmental process GO:0050793 8.8 NOTCH3 NOTCH2 NOTCH1

Sources for Lung Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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