MCID: LNG030
MIFTS: 35

Lung Adenoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Adenoma

MalaCards integrated aliases for Lung Adenoma:

Name: Lung Adenoma 12 15
Adenoma of Lung 12 73
Pulmonary Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5386
NCIt 50 C4455
SNOMED-CT 68 254642004
UMLS 73 C0345964

Summaries for Lung Adenoma

MalaCards based summary : Lung Adenoma, also known as adenoma of lung, is related to adenoma and adenocarcinoma. An important gene associated with Lung Adenoma is C18orf54 (Chromosome 18 Open Reading Frame 54), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Affiliated tissues include lung and skin, and related phenotypes are cellular and embryo

Related Diseases for Lung Adenoma

Graphical network of the top 20 diseases related to Lung Adenoma:



Diseases related to Lung Adenoma

Symptoms & Phenotypes for Lung Adenoma

MGI Mouse Phenotypes related to Lung Adenoma:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 NOTCH1 CCNE1 CDK2 ALDH1A1 NOTCH3 RARB
2 embryo MP:0005380 10.15 CDK2 NOTCH2 ALDH1A1 NOTCH1 CCNE1 NOTCH3
3 endocrine/exocrine gland MP:0005379 10.14 CDK2 NOTCH2 ALDH1A1 NOTCH1 CCNE1 NOTCH3
4 growth/size/body region MP:0005378 10.13 NOTCH1 CCNE1 CDK2 ALDH1A1 NOTCH3 NOTCH2
5 cardiovascular system MP:0005385 10.12 NOTCH1 CCNE1 CDK2 NOTCH3 RARB NOTCH2
6 hematopoietic system MP:0005397 10.04 CCNE1 NOTCH1 CDK2 RAF1 NOTCH3 NOTCH2
7 immune system MP:0005387 10.02 CCNE1 NOTCH1 CDK2 NOTCH2 RAF1 NOTCH3
8 mortality/aging MP:0010768 10.01 CCNE1 NOTCH1 CDK2 ALDH1A1 RAF1 NOTCH3
9 craniofacial MP:0005382 9.96 NOTCH1 ALDH1A1 RAF1 NOTCH2 RARB
10 integument MP:0010771 9.93 NOTCH1 CCNE1 CDK2 RAF1 NOTCH3 NOTCH2
11 muscle MP:0005369 9.85 NOTCH1 CDK2 NOTCH3 RARB NOTCH2 RAF1
12 liver/biliary system MP:0005370 9.83 NOTCH1 CDK2 ALDH1A1 NOTCH2 RAF1
13 hearing/vestibular/ear MP:0005377 9.81 NOTCH1 RAF1 NOTCH3 RARB
14 neoplasm MP:0002006 9.8 CCNE1 CDK2 NOTCH1 NOTCH3 NOTCH2 RAF1
15 normal MP:0002873 9.8 CCNE1 ALDH1A1 NOTCH1 NOTCH3 RARB NOTCH2
16 respiratory system MP:0005388 9.63 NOTCH1 ALDH1A1 NOTCH3 RARB NOTCH2 RAF1
17 skeleton MP:0005390 9.43 CCNE1 NOTCH1 RAF1 NOTCH3 NOTCH2 RARB
18 vision/eye MP:0005391 9.17 CDK2 NOTCH2 ALDH1A1 NOTCH1 NOTCH3 RARB

Drugs & Therapeutics for Lung Adenoma

Search Clinical Trials , NIH Clinical Center for Lung Adenoma

Genetic Tests for Lung Adenoma

Anatomical Context for Lung Adenoma

MalaCards organs/tissues related to Lung Adenoma:

41
Lung, Skin

Publications for Lung Adenoma

Articles related to Lung Adenoma:

(show all 45)
# Title Authors Year
1
Effects of talactoferrin alpha on lung adenoma prevention in A/J mice June 2, 2016. ( 29636877 )
2018
2
FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas. ( 29267283 )
2017
3
Safety and Preclinical Efficacy of Aerosol Pioglitazone on Lung Adenoma Prevention in A/J Mice. ( 27993834 )
2016
4
Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice. ( 27293987 )
2016
5
Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. ( 26030593 )
2015
6
Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway. ( 26472723 )
2015
7
ALDH maintains the stemness of lung adenoma stem cells by suppressing the Notch/CDK2/CCNE pathway. ( 24671051 )
2014
8
Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice. ( 23304102 )
2012
9
Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene. ( 17671688 )
2007
10
Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. ( 17363568 )
2007
11
Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. ( 17974961 )
2007
12
beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model. ( 16898870 )
2006
13
The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model. ( 16632869 )
2006
14
Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. ( 16051643 )
2005
15
Phenotypic characteristics of mouse lung adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. ( 15584020 )
2005
16
Inhibition of benzo(a)pyrene induced lung adenoma by panax ginseng extract, EFLA400, in Swiss albino mice. ( 16272690 )
2005
17
Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice. ( 15703070 )
2005
18
Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure. ( 15171791 )
2004
19
Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch. ( 12727849 )
2003
20
Indomethacin reduces lung adenoma number in A/J mice. ( 11497255 )
2001
21
The effect of exposure to a commercial 2,4-D herbicide formulation during gestation on urethan-induced lung adenoma formation in CD-1 mice. ( 10839313 )
2000
22
Thymosinalpha1 is chemopreventive for lung adenoma formation in A/J mice. ( 10822126 )
2000
23
Expression of human Krev-1 gene in lungs of transgenic mice and subsequent reduction in multiplicity of ethyl carbamate-induced lung adenomas. ( 8890957 )
1996
24
Lung adenoma development and NK activity in mice treated with multiple carcinogens. ( 1418756 )
1992
25
The effects of Tordon 202c exposure on urethan-induced lung adenoma formation in female CD-1 mice. ( 1858296 )
1991
26
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens. ( 1771369 )
1991
27
Lung adenoma structure among inbred strains of mice: the pulmonary adenoma histologic type (Pah) genes. ( 1764694 )
1991
28
Enhanced malignant phenotype of urethane-induced lung adenoma associated with sialoadenectomy in BALB/c mice. ( 2786772 )
1989
29
Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay. ( 3365834 )
1988
30
Malignant epithelial cell strains cultured from BALB/c mouse lung adenoma. ( 3829131 )
1987
31
Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethan and benzo(a)pyrene. ( 3480057 )
1987
32
Comparison of two routes of chemical administration on the lung adenoma response in strain A/J mice. ( 3945940 )
1986
33
A combined carcinogen bioassay utilizing both the lung adenoma and skin papilloma protocols. ( 3780626 )
1986
34
A comparison of the lung adenoma response in strain A/J mice after intraperitoneal and oral administration of carcinogens. ( 6695378 )
1984
35
Bacterial and mammalian cell mutagenesis, sister-chromatid exchange, and mouse lung adenoma bioassay with the antineoplastic acridine derivative amsacrine. ( 6394768 )
1984
36
Pharmacologic and genetic studies on the modulatory effects of butylated hydroxytoluene on mouse lung adenoma formation. ( 6592388 )
1984
37
Establishment of epithelial cell strains from normal adult mouse lung resembling a urethane-induced lung adenoma cell strain and a metastasizing mouse lung carcinoma cell line. ( 6713549 )
1984
38
Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay. ( 6488452 )
1984
39
Effect of 12-O-tetradecanoylphorbol-13-acetate on polyamine metabolism in mice sensitive and resistant to lung-adenoma. ( 6616764 )
1983
40
Inflammatory pseudotumor and lung adenoma. ( 100292 )
1978
41
Lecithin biosynthesis in a clonal line of lung adenoma cells with type II alveolar cell properties. ( 581072 )
1978
42
Clonal isolation of epithelial cells from mouse lung adenoma. ( 167947 )
1975
43
Enhancement of lung adenoma formation by neonatal thymectomy in mice treated with 7,12-dimethylbenz(a)anthracene or urethan. ( 6055972 )
1967
44
Urethan carcinogenesis and nucleic acid metabolism: factors influencing lung adenoma induction. ( 5921493 )
1966
45
Mammary tumor inhibition and lung adenoma induction by isonicotinic acid hydrazide. ( 5937130 )
1966

Variations for Lung Adenoma

Expression for Lung Adenoma

Search GEO for disease gene expression data for Lung Adenoma.

Pathways for Lung Adenoma

Pathways related to Lung Adenoma according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 ALDH1A1 CCNE1 CDK2 NOTCH1 NOTCH2 NOTCH3
2
Show member pathways
13.62 CCNE1 CDK2 NOTCH1 NOTCH2 NOTCH3 RAF1
3
Show member pathways
12.63 CCNE1 CDK2 NOTCH1 NOTCH2 NOTCH3 RAF1
4 12.42 CCNE1 CDK2 NOTCH1 NOTCH2 NOTCH3 RAF1
5
Show member pathways
12.25 NOTCH1 NOTCH2 NOTCH3
6
Show member pathways
12.17 CCNE1 CDK2 RAF1
7
Show member pathways
12.17 CCNE1 CDK2 RAF1
8
Show member pathways
12.17 CCNE1 CDK2 NOTCH1 NOTCH2 NOTCH3 RAF1
9 12.13 CCNE1 NOTCH1 NOTCH2 NOTCH3 RAF1
10 12.06 NOTCH1 NOTCH2 NOTCH3
11 11.99 CCNE1 CDK2 RAF1
12
Show member pathways
11.93 NOTCH1 NOTCH2 NOTCH3
13 11.91 NOTCH1 NOTCH2 NOTCH3
14
Show member pathways
11.84 NOTCH1 NOTCH2 NOTCH3
15
Show member pathways
11.83 CCNE1 CDK2 NOTCH1 NOTCH2 NOTCH3 RAF1
16 11.8 NOTCH1 NOTCH2 NOTCH3
17 11.77 CCNE1 CDK2 RAF1
18 11.73 NOTCH1 NOTCH2 NOTCH3 RAF1
19 11.72 NOTCH1 NOTCH2 NOTCH3
20 11.67 CCNE1 CDK2 RARB
21 11.64 NOTCH1 NOTCH2 NOTCH3
22 11.62 CCNE1 CDK2 RAF1
23 11.49 CCNE1 CDK2 RAF1
24 11.42 CCNE1 CDK2 RAF1
25 11.36 CCNE1 CDK2 RAF1
26 11.35 CDK2 RAF1
27 11.31 CCNE1 CDK2
28 11.3 ALDH1A1 RARB
29 11.19 NOTCH1 NOTCH2
30 11.14 CCNE1 CDK2
31 11.09 CCNE1 CDK2
32 11.01 NOTCH1 NOTCH2 NOTCH3
33 10.98 CCNE1 CDK2
34 10.88 CCNE1 CDK2
35 10.78 CCNE1 CDK2

GO Terms for Lung Adenoma

Cellular components related to Lung Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.33 NOTCH1 NOTCH2 NOTCH3
2 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.96 CCNE1 CDK2
3 cyclin E1-CDK2 complex GO:0097134 8.62 CCNE1 CDK2

Biological processes related to Lung Adenoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.89 NOTCH1 NOTCH2 NOTCH3 RAF1 RARB
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.77 CCNE1 CDK2 NOTCH1 NOTCH3 RARB
3 negative regulation of cell proliferation GO:0008285 9.76 C18orf54 NOTCH1 RAF1 RARB
4 heart development GO:0007507 9.73 NOTCH1 RAF1 RARB
5 multicellular organism development GO:0007275 9.73 CDK2 NOTCH1 NOTCH2 NOTCH3 RAF1 RARB
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.72 NOTCH1 NOTCH2 RAF1
7 Notch signaling pathway GO:0007219 9.61 NOTCH1 NOTCH2 NOTCH3
8 embryonic hindlimb morphogenesis GO:0035116 9.54 NOTCH1 RARB
9 neuron fate commitment GO:0048663 9.52 NOTCH1 NOTCH3
10 positive regulation of Ras protein signal transduction GO:0046579 9.51 NOTCH1 NOTCH2
11 positive regulation of transcription of Notch receptor target GO:0007221 9.48 NOTCH1 NOTCH3
12 transcription initiation from RNA polymerase II promoter GO:0006367 9.46 NOTCH1 NOTCH2 NOTCH3 RARB
13 pulmonary valve morphogenesis GO:0003184 9.4 NOTCH1 NOTCH2
14 Notch signaling involved in heart development GO:0061314 9.32 NOTCH1 NOTCH2
15 negative regulation of growth rate GO:0045967 8.96 NOTCH1 NOTCH2
16 regulation of developmental process GO:0050793 8.8 NOTCH1 NOTCH2 NOTCH3

Sources for Lung Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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