MCID: LNG031
MIFTS: 46

Lung Benign Neoplasm

Categories: Cancer diseases, Respiratory diseases, Genetic diseases

Aliases & Classifications for Lung Benign Neoplasm

MalaCards integrated aliases for Lung Benign Neoplasm:

Name: Lung Benign Neoplasm 12 15
Lung Neoplasms 44 73
Tumor of the Lung 12
Lung Tumor 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3683
MeSH 44 D008175
NCIt 50 C3200
SNOMED-CT 68 126713003
UMLS 73 C0024121

Summaries for Lung Benign Neoplasm

MalaCards based summary : Lung Benign Neoplasm, also known as lung neoplasms, is related to carcinoid syndrome and glomus tumor, and has symptoms including hemoptysis An important gene associated with Lung Benign Neoplasm is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Developmental Biology and PI3K-Akt signaling pathway. Affiliated tissues include lung and fetal lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Lung Benign Neoplasm

Diseases in the Lung Cancer family:

Lung Benign Neoplasm Lung Carcinoma in Situ

Diseases related to Lung Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 carcinoid syndrome 30.7 CHGA ENO2 SYP
2 glomus tumor 30.3 ENO2 SYP TP53
3 cystadenoma 29.8 CHGA KRT7 SYP
4 pulmonary sclerosing hemangioma 29.5 CHGA KRT7 NKX2-1 SYP
5 sclerosing hemangioma 29.2 CHGA ENO2 KRT7 NKX2-1 SYP
6 neuroendocrine tumor 29.1 CHGA ENO2 KRT7 NCAM1 NKX2-1 SYP
7 small cell carcinoma 26.5 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
8 lung cancer 24.9 CADM1 CHGA EGFR ENO2 HRAS KRAS
9 hilar lung neoplasm 11.9
10 rare adenocarcinoma of the breast 11.0 KRAS TP53
11 solid adenocarcinoma with mucin production 10.9 KRT7 NKX2-1
12 hyperplastic polyposis syndrome 10.9 KRAS TP53
13 ovarian germ cell teratoma 10.8 KRT7 NKX2-1
14 malignant spiradenoma 10.8 KRT7 TP53
15 lung acinar adenocarcinoma 10.8 KRT7 NKX2-1
16 ovarian germ cell cancer 10.8 KRT7 NKX2-1
17 intracranial primitive neuroectodermal tumor 10.8 CHGA ENO2
18 female reproductive endometrioid cancer 10.8 KRT7 TP53
19 malignant sertoli cell tumor 10.8 ENO2 SYP
20 vaginal benign neoplasm 10.7 CHGA KRT7
21 ovary neuroendocrine neoplasm 10.7 KRT7 SYP
22 vaginal adenoma 10.7 CHGA KRT7
23 sigmoid neoplasm 10.7 HRAS KRAS
24 vaginal tubulovillous adenoma 10.7 CHGA KRT7
25 eccrine sweat gland neoplasm 10.7 KRT7 TP53
26 pleuropulmonary blastoma 10.7
27 sinonasal undifferentiated carcinoma 10.7 ENO2 SYP
28 apocrine adenoma 10.7 HRAS KRAS
29 olfactory groove meningioma 10.7 CHGA TP53
30 mucinous adenofibroma 10.7 KRT7 SYP
31 chromosome 14q11-q22 deletion syndrome 10.7 HRAS NKX2-1
32 embryoma 10.7 NKX2-1 SYP
33 pancreatic somatostatinoma 10.7 ENO2 SYP
34 mutyh-associated polyposis 10.7 KRAS TP53
35 mucinous bronchioloalveolar adenocarcinoma 10.7 KRT7 NKX2-1
36 papillary serous adenocarcinoma 10.7 KRT7 NKX2-1 TP53
37 papillary tumor of the pineal region 10.7 ENO2 SYP
38 pseudomyxoma peritonei 10.6 KRAS KRT7 TP53
39 epithelioid malignant peripheral nerve sheath tumor 10.6 CHGA ENO2
40 adenoma of the pancreas 10.6 CHGA SYP
41 schimmelpenning-feuerstein-mims syndrome 10.6 HRAS KRAS
42 papillary adenoma 10.6 KRT7 NKX2-1
43 ovarian clear cell carcinoma 10.6 KRAS KRT7 TP53
44 periampullary adenoma 10.6 HRAS KRAS
45 acinar cell cystadenocarcinoma 10.6 CHGA SYP
46 papillary adenocarcinoma 10.6 KRT7 NKX2-1 TP53
47 ovarian carcinosarcoma 10.6 ENO2 SYP
48 primary hepatic neuroendocrine carcinoma 10.6 CHGA SYP
49 goblet cell carcinoid 10.6 CHGA ENO2
50 small intestine cancer 10.6 ENO2 KRAS KRT7

Graphical network of the top 20 diseases related to Lung Benign Neoplasm:



Diseases related to Lung Benign Neoplasm

Symptoms & Phenotypes for Lung Benign Neoplasm

UMLS symptoms related to Lung Benign Neoplasm:


hemoptysis

GenomeRNAi Phenotypes related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.11 NCAM1 EGFR HRAS KRAS
2 Decreased viability GR00106-A-0 10.11 KRAS
3 Decreased viability GR00221-A-1 10.11 KRAS EGFR HRAS
4 Decreased viability GR00221-A-2 10.11 KRAS HRAS
5 Decreased viability GR00221-A-3 10.11 HRAS
6 Decreased viability GR00221-A-4 10.11 EGFR
7 Decreased viability GR00301-A 10.11 KRAS
8 Decreased viability GR00381-A-1 10.11 KRAS
9 Decreased viability GR00402-S-2 10.11 KRAS NCAM1 EGFR HRAS
10 Increased cell migration GR00055-A-3 9.26 KRAS NCAM1 EGFR HRAS
11 Reduced mammosphere formation GR00396-S 9.17 KRAS KRT7 NCAM1 RARB CHGA EGFR

MGI Mouse Phenotypes related to Lung Benign Neoplasm:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 NKX2-1 KRAS RAF1 ENO2 CADM1 NCAM1
2 growth/size/body region MP:0005378 10.26 NKX2-1 EGFR KRAS SCGB1A1 RAF1 ENO2
3 cellular MP:0005384 10.22 RARB NKX2-1 EGFR KRAS ENO2 CADM1
4 mortality/aging MP:0010768 10.2 HRAS RARB NKX2-1 EGFR KRAS RAF1
5 cardiovascular system MP:0005385 10.19 HRAS RARB NKX2-1 EGFR KRAS RAF1
6 endocrine/exocrine gland MP:0005379 10.19 NKX2-1 EGFR KRAS SCGB1A1 RAF1 CADM1
7 nervous system MP:0003631 10.14 RARB NKX2-1 EGFR KRAS RAF1 ENO2
8 craniofacial MP:0005382 10.05 HRAS RARB EGFR KRAS RAF1 ENO2
9 neoplasm MP:0002006 10.03 EGFR KRAS SCGB1A1 RAF1 HRAS NKX2-1
10 normal MP:0002873 10.02 EGFR KRAS SCGB1A1 RAF1 CADM1 HRAS
11 no phenotypic analysis MP:0003012 9.97 NKX2-1 EGFR KRAS RAF1 CHGA HRAS
12 renal/urinary system MP:0005367 9.86 EGFR KRAS SCGB1A1 KRT7 CHGA HRAS
13 reproductive system MP:0005389 9.76 RARB NKX2-1 EGFR KRAS CADM1 CHGA
14 respiratory system MP:0005388 9.65 KRAS SCGB1A1 RAF1 ENO2 HRAS RARB
15 vision/eye MP:0005391 9.17 RARB EGFR KRAS RAF1 NCAM1 TP53

Drugs & Therapeutics for Lung Benign Neoplasm

Genetic Tests for Lung Benign Neoplasm

Anatomical Context for Lung Benign Neoplasm

MalaCards organs/tissues related to Lung Benign Neoplasm:

41
Lung, Fetal Lung

Publications for Lung Benign Neoplasm

Articles related to Lung Benign Neoplasm:

(show all 29)
# Title Authors Year
1
Insulinoma-associated protein 1 is a sensitive and specific marker of neuroendocrine lung neoplasms in cytology specimens. ( 29360191 )
2018
2
Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. ( 26374070 )
2015
3
Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene. ( 23703846 )
2014
4
Panhypopituitarism and lung neoplasm: A case study. ( 23769487 )
2013
5
Gene therapy for lung neoplasms. ( 22054892 )
2011
6
GCDFP-15 positive and TTF-1 negative primary lung neoplasms: a tissue microarray study of 381 primary lung tumors. ( 19620839 )
2009
7
Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. ( 18413732 )
2008
8
Primary pulmonary synovial sarcoma, a rare primary lung neoplasm: two case reports and review of the current literature. ( 18713096 )
2008
9
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT. ( 16395694 )
2007
10
Expression of matrix metalloproteinases 3, 10 and 11 (stromelysins 1, 2 and 3) and matrix metalloproteinase 7 (matrilysin) by cancer cells in non-small cell lung neoplasms. Clinicopathologic studies. ( 16506596 )
2006
11
Discrimination of human lung neoplasm from normal lung by two target genes. ( 15331390 )
2004
12
[Molecular targetting therapy for non-small-cell lung neoplasms with EGF-R inhibitors]. ( 12652739 )
2003
13
Lung neoplasm mimicking an acute lateral myocardial infarction. ( 14608295 )
2003
14
Intrathoracic desmoid tumor mimicking primary lung neoplasm. ( 11383835 )
2001
15
Glucose transporter expression in developing fetal lungs and lung neoplasms. ( 10425560 )
1999
16
Tumor markers kinetic in malignant lung neoplasms. ( 10350122 )
1999
17
Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: an immunohistochemical study. ( 9158711 )
1997
18
Cytometry with DAPI-stained tumor imprints. A reliable tool for improved intraoperative analysis of lung neoplasms. ( 8744500 )
1996
19
[Incidence of beta HCG elevation in serum of patients with small cell lung neoplasms and their prognosis]. ( 8616477 )
1995
20
[Comparison of the degree of regression of small cell lung neoplasm in clinical-radiologic evaluation with levels of neuron specific enolase (NSE) in serum]. ( 8616474 )
1995
21
[Prognostic value of neuron enolase levels in serum of patients with lung neoplasms]. ( 8520560 )
1995
22
Expression of epidermal growth factor receptor in plutonium-239-induced lung neoplasms in dogs. ( 1313613 )
1992
23
[Activity of angiotensin I converting enzyme in serum and bronchoalveolar lavage fluid of patients with sarcoidosis and lung neoplasms]. ( 1668848 )
1991
24
[Usefulness of simultaneous antigenic determination of carcinoembryonic antigen (CEA), ferritin and orosomucoid levels in diagnosis of lung neoplasms]. ( 1843646 )
1991
25
[Histochemical localization of glyco-conjugate and CEA-glycoprotein in human lung neoplasms]. ( 2249589 )
1990
26
[Tumor markers. I. Their significance in the preoperative assessment of lung neoplasms]. ( 1964495 )
1990
27
Unusual primary lung neoplasms: spindle cell and undifferentiated lung carcinomas expressing only vimentin. ( 2247906 )
1990
28
[Tumor markers. II. Their significance in the follow-up of patients after radical resection of lung neoplasms]. ( 2082204 )
1990
29
Cryofibrinogen in a case of lung neoplasm associated with thrombophlebitis migrans. ( 13250040 )
1955

Variations for Lung Benign Neoplasm

Expression for Lung Benign Neoplasm

Search GEO for disease gene expression data for Lung Benign Neoplasm.

Pathways for Lung Benign Neoplasm

Pathways related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 EGFR HRAS KRAS KRT7 NCAM1 RAF1
2
Show member pathways
12.94 EGFR HRAS KRAS RAF1 TP53
3
Show member pathways
12.84 EGFR HRAS KRAS RAF1 TP53
4 12.77 EGFR HRAS KRAS RAF1 RARB TP53
5 12.74 EGFR HRAS KRAS RAF1 TP53
6
Show member pathways
12.66 EGFR HRAS KRAS RAF1 RARB TP53
7
Show member pathways
12.64 EGFR HRAS KRAS RAF1 RARB TP53
8
Show member pathways
12.63 EGFR HRAS KRAS RAF1 TP53
9 12.59 EGFR HRAS KRAS RAF1
10 12.56 ENO2 NCAM1 NKX2-1 SYP
11
Show member pathways
12.56 EGFR HRAS KRAS TP53
12
Show member pathways
12.54 HRAS KRAS RAF1 TP53
13
Show member pathways
12.51 EGFR HRAS KRAS RAF1 TP53
14 12.49 EGFR HRAS KRAS RAF1 TP53
15
Show member pathways
12.46 EGFR HRAS KRAS RAF1 TP53
16
Show member pathways
12.42 EGFR HRAS KRAS TP53
17
Show member pathways
12.42 EGFR HRAS KRAS RAF1 TP53
18
Show member pathways
12.38 EGFR HRAS KRAS RAF1
19
Show member pathways
12.38 EGFR HRAS KRAS RAF1
20
Show member pathways
12.22 EGFR HRAS KRAS RAF1
21
Show member pathways
12.2 HRAS KRAS RAF1 TP53
22 12.18 EGFR HRAS KRAS RAF1
23
Show member pathways
12.17 HRAS KRAS RAF1 TP53
24 12.16 HRAS KRAS RAF1 TP53
25 12.16 EGFR HRAS KRAS RAF1 TP53
26
Show member pathways
12.13 HRAS KRAS RAF1 TP53
27
Show member pathways
12.13 EGFR HRAS KRAS RAF1
28
Show member pathways
12.07 EGFR HRAS KRAS RAF1
29
Show member pathways
12.05 EGFR KRAS RAF1
30 12.03 EGFR HRAS KRAS RAF1 TP53
31 12.02 HRAS KRAS RAF1
32
Show member pathways
12.02 HRAS RAF1 TP53
33
Show member pathways
12.01 EGFR RAF1 TP53
34
Show member pathways
12 HRAS KRAS RAF1
35 12 HRAS KRAS RAF1
36
Show member pathways
11.99 HRAS KRAS RAF1
37 11.98 HRAS KRAS RAF1 TP53
38 11.97 HRAS KRAS RAF1 TP53
39 11.96 HRAS KRAS TP53
40 11.95 HRAS KRAS RAF1
41 11.95 HRAS KRAS RAF1
42
Show member pathways
11.93 EGFR HRAS KRAS
43 11.92 HRAS RAF1 TP53
44 11.88 EGFR HRAS KRAS RAF1
45 11.88 EGFR HRAS KRAS RAF1 TP53
46
Show member pathways
11.84 EGFR HRAS KRAS
47
Show member pathways
11.8 HRAS KRAS RAF1
48 11.77 EGFR HRAS KRAS RAF1
49 11.7 EGFR HRAS KRAS RAF1 TP53
50 11.68 HRAS RAF1 TP53

GO Terms for Lung Benign Neoplasm

Biological processes related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 EGFR HRAS NKX2-1 RAF1 RARB TP53
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.71 HRAS KRAS RAF1
3 liver development GO:0001889 9.65 EGFR KRAS RARB
4 Ras protein signal transduction GO:0007265 9.63 HRAS KRAS TP53
5 axon guidance GO:0007411 9.62 HRAS KRAS NCAM1 NKX2-1
6 positive regulation of MAP kinase activity GO:0043406 9.58 EGFR HRAS KRAS
7 positive regulation of protein phosphorylation GO:0001934 9.56 EGFR HRAS KRAS RAF1
8 epidermal growth factor receptor signaling pathway GO:0007173 9.54 EGFR HRAS KRAS
9 epithelial tube branching involved in lung morphogenesis GO:0060441 9.52 KRAS NKX2-1
10 cerebral cortex cell migration GO:0021795 9.49 EGFR NKX2-1
11 response to isolation stress GO:0035900 9.43 HRAS KRAS
12 MAPK cascade GO:0000165 9.35 EGFR HRAS KRAS NCAM1 RAF1
13 ERBB2 signaling pathway GO:0038128 9.33 EGFR HRAS KRAS
14 regulation of long-term neuronal synaptic plasticity GO:0048169 8.8 HRAS KRAS SYP

Molecular functions related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.92 EGFR NKX2-1 RAF1 TP53

Sources for Lung Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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