MCID: LNG031
MIFTS: 53

Lung Benign Neoplasm

Categories: Blood diseases, Cancer diseases, Genetic diseases, Respiratory diseases

Aliases & Classifications for Lung Benign Neoplasm

MalaCards integrated aliases for Lung Benign Neoplasm:

Name: Lung Benign Neoplasm 12 15
Lung Neoplasms 44 73
Tumor of the Lung 12
Lung Tumor 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3683
MeSH 44 D008175
NCIt 50 C3200
UMLS 73 C0024121

Summaries for Lung Benign Neoplasm

MalaCards based summary : Lung Benign Neoplasm, also known as lung neoplasms, is related to carcinoid syndrome and pulmonary blastoma, and has symptoms including hemoptysis An important gene associated with Lung Benign Neoplasm is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. Affiliated tissues include lung, testes and brain, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Lung Benign Neoplasm

Diseases in the Lung Cancer family:

Lung Benign Neoplasm Lung Carcinoma in Situ

Diseases related to Lung Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)
# Related Disease Score Top Affiliating Genes
1 carcinoid syndrome 30.6 CHGA ENO2 SYP
2 pulmonary blastoma 30.2 CHGA EGFR KRAS NKX2-1 SYP TP53
3 glomus tumor 30.1 ENO2 SYP TP53
4 interstitial lung disease 29.8 EGFR NKX2-1 SFTPB
5 mucoepidermoid carcinoma 29.8 CHGA EGFR KRT7
6 cystadenoma 29.7 CHGA KRT7 SYP
7 paraganglioma 29.7 CHGA ENO2 SYP
8 alveoli adenoma 29.7 KRAS KRT7 NKX2-1 SCGB1A1
9 rhabdoid cancer 29.7 ENO2 SYP TP53
10 lung disease 29.6 EGFR GRP NKX2-1 SFTPB
11 sclerosing hemangioma 29.6 CHGA KRT7 NKX2-1 SFTPB SYP
12 neuroendocrine tumor 29.5 CHGA ENO2 GRP KRT7 NCAM1 NKX2-1
13 hemangioma 29.4 CHGA ENO2 KRAS NKX2-1 SFTPB SYP
14 myeloma, multiple 29.4 HRAS KRAS NCAM1 TP53
15 pleomorphic carcinoma 29.4 EGFR KRT7 NKX2-1 TP53
16 mucinous adenocarcinoma 29.4 EGFR KRAS KRT7 NKX2-1
17 basaloid squamous cell carcinoma 29.4 EGFR ENO2 KRT7 SYP TP53
18 ganglioglioma 29.4 CHGA ENO2 SYP TP53
19 pulmonary sclerosing hemangioma 29.4 CHGA KRT7 NKX2-1 SFTPB SYP
20 lung squamous cell carcinoma 29.4 EGFR HRAS KRAS TP53
21 malignant pheochromocytoma 29.3 CHGA ENO2 SYP
22 adenocarcinoma 29.3 EGFR HRAS KRAS RAF1 TP53
23 sarcoma 29.2 HRAS KRAS RAF1 TP53
24 thyroid cancer 29.2 CHGA EGFR HRAS KRAS NKX2-1 TP53
25 squamous cell carcinoma, head and neck 29.1 EGFR FHIT HRAS TP53
26 small cell cancer of the lung 29.0 CHGA EGFR ENO2 GRP KRT7 NCAM1
27 large cell neuroendocrine carcinoma 29.0 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
28 ewing sarcoma 28.9 CHGA EGFR ENO2 NCAM1 SYP TP53
29 small cell carcinoma 28.9 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
30 pheochromocytoma 28.8 CHGA ENO2 NCAM1 RAF1 SYP
31 lung cancer susceptibility 3 28.0 CADM1 EGFR FHIT HRAS KRAS KRT7
32 lung cancer 27.2 CADM1 CHGA EGFR ENO2 FHIT GRP
33 hilar lung neoplasm 12.1
34 bronchiectasis 11.2
35 rhabdomyosarcoma 2 10.9
36 pleuropulmonary blastoma 10.8
37 inflammatory myofibroblastic tumor 10.4
38 ovarian germ cell cancer 10.3 KRT7 NKX2-1
39 solid adenocarcinoma with mucin production 10.3 KRT7 NKX2-1
40 papillary adenoma 10.3 KRT7 NKX2-1
41 colloid adenoma 10.3 NKX2-1 TP53
42 duodenum adenocarcinoma 10.3 KRAS KRT7
43 ovarian germ cell teratoma 10.3 KRT7 NKX2-1
44 lung acinar adenocarcinoma 10.3 KRT7 NKX2-1
45 mutyh-associated polyposis 10.3 KRAS TP53
46 rare adenocarcinoma of the breast 10.3 KRAS TP53
47 hyperplastic polyposis syndrome 10.3 KRAS TP53
48 bladder carcinoma in situ 10.3 KRT7 TP53
49 malignant spiradenoma 10.3 KRT7 TP53
50 pleuropulmonary blastoma type 1 10.3

Graphical network of the top 20 diseases related to Lung Benign Neoplasm:



Diseases related to Lung Benign Neoplasm

Symptoms & Phenotypes for Lung Benign Neoplasm

UMLS symptoms related to Lung Benign Neoplasm:


hemoptysis

GenomeRNAi Phenotypes related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.91 EGFR HRAS KRAS NCAM1
2 Decreased viability GR00106-A-0 9.91 KRAS
3 Decreased viability GR00221-A-1 9.91 EGFR HRAS KRAS
4 Decreased viability GR00221-A-2 9.91 HRAS KRAS
5 Decreased viability GR00221-A-3 9.91 HRAS
6 Decreased viability GR00221-A-4 9.91 EGFR
7 Decreased viability GR00301-A 9.91 KRAS
8 Decreased viability GR00381-A-1 9.91 KRAS
9 Decreased viability GR00402-S-2 9.91 EGFR HRAS KRAS NCAM1
10 Increased cell migration GR00055-A-3 8.92 EGFR HRAS KRAS NCAM1

MGI Mouse Phenotypes related to Lung Benign Neoplasm:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 CADM1 ENO2 GRP HRAS KRAS NCAM1
2 homeostasis/metabolism MP:0005376 10.17 CHGA EGFR FHIT HRAS KRAS KRT7
3 growth/size/body region MP:0005378 10.16 CADM1 CHGA EGFR ENO2 HRAS KRAS
4 mortality/aging MP:0010768 10.14 CHGA EGFR FHIT HRAS KRAS NCAM1
5 endocrine/exocrine gland MP:0005379 10.13 CADM1 CHGA EGFR HRAS KRAS NKX2-1
6 nervous system MP:0003631 10.1 CADM1 CHGA EGFR ENO2 GRP HRAS
7 craniofacial MP:0005382 9.97 EGFR ENO2 HRAS KRAS RAF1 TP53
8 neoplasm MP:0002006 9.97 EGFR FHIT HRAS KRAS NKX2-1 RAF1
9 normal MP:0002873 9.81 CADM1 EGFR HRAS KRAS NKX2-1 RAF1
10 no phenotypic analysis MP:0003012 9.8 CHGA EGFR HRAS KRAS NKX2-1 RAF1
11 renal/urinary system MP:0005367 9.5 CHGA EGFR HRAS KRAS KRT7 SCGB1A1
12 respiratory system MP:0005388 9.28 EGFR ENO2 HRAS KRAS NKX2-1 RAF1

Drugs & Therapeutics for Lung Benign Neoplasm

Genetic Tests for Lung Benign Neoplasm

Anatomical Context for Lung Benign Neoplasm

MalaCards organs/tissues related to Lung Benign Neoplasm:

41
Lung, Testes, Brain, Lymph Node, Breast, Thyroid, Bone

Publications for Lung Benign Neoplasm

Articles related to Lung Benign Neoplasm:

(show top 50) (show all 85)
# Title Authors Year
1
Insulinoma-associated protein 1 is a sensitive and specific marker of neuroendocrine lung neoplasms in cytology specimens. ( 29360191 )
2018
2
Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections. ( 30154579 )
2018
3
Lung Neoplasms with Low F18-Fluorodeoxyglucose Avidity. ( 29157381 )
2018
4
CT-guided percutaneous radiofrequency ablation for lung neoplasms adjacent to the pericardium. ( 30032841 )
2018
5
Microwave Ablation for Lung Neoplasms: A Retrospective Analysis of Long-Term Results. ( 27993505 )
2017
6
Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms. ( 27602958 )
2016
7
Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. ( 26374070 )
2015
8
Utility of telepathology as a consultation tool between an off-site surgical pathology suite and affiliated hospitals in the frozen section diagnosis of lung neoplasms. ( 26605120 )
2015
9
Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene. ( 23703846 )
2014
10
Differentiation of lung neoplasms with lepidic growth and good prognosis from those with poor prognosis using computer-aided 3D volumetric CT analysis and FDG-PET. ( 24003260 )
2014
11
Higher susceptibility of spontaneous and NNK-induced lung neoplasms in connexin 43 deficient CD1 × AJ F1 mice: paradoxical expression of connexin 43 during lung carcinogenesis. ( 22344786 )
2013
12
Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images. ( 24376755 )
2013
13
Low-sensitivity FDG-PET studies: less common lung neoplasms. ( 22681674 )
2012
14
Difference in clonality as a tool for differential diagnosis of primary versus secondary lung neoplasms. ( 22722795 )
2012
15
Use of endobronchial valves for the treatment of bronchopleural fistulas after thermal ablation of lung neoplasms. ( 22920983 )
2012
16
Gene therapy for lung neoplasms. ( 22054892 )
2011
17
The efficacy of bipolar and multipolar radiofrequency ablation of lung neoplasms - results of an ablate and resect study. ( 20961771 )
2011
18
Diagnostic issues with cytopathologic interpretation of lung neoplasms displaying high-grade basaloid or neuroendocrine morphology. ( 21319315 )
2011
19
GCDFP-15 positive and TTF-1 negative primary lung neoplasms: a tissue microarray study of 381 primary lung tumors. ( 19620839 )
2009
20
Clinical significance of tumor-infiltrating lymphocytes in lung neoplasms. ( 19161739 )
2009
21
Research reporting standards for percutaneous thermal ablation of lung neoplasms. ( 19246213 )
2009
22
Tumour characteristics and therapeutic results after percutaneous radiofrequency ablation of secondary lung neoplasms. ( 19531455 )
2009
23
Risk factors involved in the development of pneumothorax during radiofrequency ablation of lung neoplasms. ( 19542382 )
2009
24
Incidence and outcomes of malignant pediatric lung neoplasms. ( 19631347 )
2009
25
Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. ( 18413732 )
2008
26
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene. ( 18648094 )
2008
27
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT. ( 16395694 )
2007
28
Risk factors for occurrence of local tumor progression after percutaneous radiofrequency ablation for lung neoplasms. ( 18092293 )
2007
29
Expression of matrix metalloproteinases 3, 10 and 11 (stromelysins 1, 2 and 3) and matrix metalloproteinase 7 (matrilysin) by cancer cells in non-small cell lung neoplasms. Clinicopathologic studies. ( 16506596 )
2006
30
Pneumothorax as a complication of percutaneous radiofrequency ablation for lung neoplasms. ( 17057004 )
2006
31
Approach to the diagnosis of neuroendocrine lung neoplasms: variabilities and pitfalls. ( 17185177 )
2006
32
Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice. ( 14713543 )
2004
33
Percutaneous radiofrequency ablation of lung neoplasms: initial therapeutic response. ( 15126656 )
2004
34
The significance of associated pre-invasive lesions in patients resected for primary lung neoplasms. ( 15200997 )
2004
35
Radiofrequency ablation of 40 lung neoplasms: preliminary results. ( 15269026 )
2004
36
Radiofrequency thermal ablation of 69 lung neoplasms. ( 15675488 )
2004
37
[Molecular targetting therapy for non-small-cell lung neoplasms with EGF-R inhibitors]. ( 12652739 )
2003
38
A review of intractable facial pain secondary to underlying lung neoplasms. ( 12534572 )
2003
39
CT findings and progression of small peripheral lung neoplasms having a replacement growth pattern. ( 12591704 )
2003
40
Increased incidence of lung neoplasms among HIV-infected men and the need for improved prevention. ( 14526218 )
2003
41
Gene therapy for lung neoplasms. ( 11901916 )
2002
42
Percutaneous radiofrequency ablation of lung neoplasms: a minimally invasive strategy for inoperable patients. ( 12229953 )
2002
43
Unusual primary lung neoplasms. ( 11470980 )
2001
44
Pulmonary complications in patients with head and neck and lung neoplasms. ( 10722023 )
2000
45
Glucose transporter expression in developing fetal lungs and lung neoplasms. ( 10425560 )
1999
46
Tumor markers kinetic in malignant lung neoplasms. ( 10350122 )
1999
47
K-ras mutations in 239PuO2 canine lung neoplasms. ( 10397446 )
1998
48
Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: an immunohistochemical study. ( 9158711 )
1997
49
Cytometry with DAPI-stained tumor imprints. A reliable tool for improved intraoperative analysis of lung neoplasms. ( 8744500 )
1996
50
Bronchoscopic, photodynamic, and laser diagnosis and therapy of lung neoplasms. ( 9363151 )
1996

Variations for Lung Benign Neoplasm

Expression for Lung Benign Neoplasm

Search GEO for disease gene expression data for Lung Benign Neoplasm.

Pathways for Lung Benign Neoplasm

Pathways related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 EGFR HRAS KRAS RAF1 TP53
2
Show member pathways
12.85 EGFR HRAS KRAS RAF1 TP53
3 12.81 EGFR HRAS KRAS RAF1 TP53
4 12.75 EGFR HRAS KRAS RAF1 TP53
5
Show member pathways
12.74 EGFR HRAS KRAS RAF1 TP53
6
Show member pathways
12.66 EGFR HRAS KRAS RAF1 TP53
7
Show member pathways
12.66 EGFR FHIT HRAS KRAS RAF1 TP53
8
Show member pathways
12.57 EGFR HRAS KRAS TP53
9 12.57 ENO2 NCAM1 NKX2-1 SYP
10
Show member pathways
12.51 EGFR HRAS KRAS RAF1 TP53
11 12.48 EGFR HRAS KRAS RAF1 TP53
12
Show member pathways
12.45 EGFR HRAS KRAS RAF1 TP53
13
Show member pathways
12.43 EGFR HRAS KRAS TP53
14
Show member pathways
12.42 EGFR HRAS KRAS RAF1 TP53
15
Show member pathways
12.41 EGFR HRAS KRAS RAF1
16
Show member pathways
12.39 EGFR HRAS KRAS RAF1
17
Show member pathways
12.39 EGFR HRAS KRAS RAF1
18
Show member pathways
12.38 EGFR HRAS KRAS RAF1
19
Show member pathways
12.24 HRAS KRAS RAF1 TP53
20
Show member pathways
12.22 EGFR HRAS KRAS RAF1
21 12.18 EGFR HRAS KRAS RAF1 TP53
22 12.17 EGFR HRAS KRAS RAF1
23 12.16 HRAS KRAS RAF1 TP53
24
Show member pathways
12.15 HRAS KRAS RAF1 TP53
25
Show member pathways
12.14 EGFR HRAS KRAS RAF1 TP53
26
Show member pathways
12.13 HRAS KRAS RAF1 TP53
27
Show member pathways
12.12 EGFR HRAS KRAS RAF1
28
Show member pathways
12.07 EGFR HRAS KRAS RAF1
29
Show member pathways
12.03 EGFR HRAS KRAS TP53
30
Show member pathways
12.01 EGFR RAF1 TP53
31 11.99 EGFR HRAS KRAS RAF1 TP53
32 11.98 HRAS KRAS RAF1 TP53
33 11.97 HRAS KRAS TP53
34 11.97 HRAS KRAS RAF1
35 11.96 HRAS KRAS RAF1 TP53
36 11.95 HRAS KRAS RAF1
37
Show member pathways
11.93 EGFR HRAS KRAS
38 11.92 HRAS RAF1 TP53
39 11.88 EGFR HRAS KRAS RAF1 TP53
40 11.86 EGFR HRAS KRAS RAF1
41
Show member pathways
11.85 EGFR HRAS KRAS
42
Show member pathways
11.8 HRAS KRAS RAF1
43 11.74 EGFR HRAS KRAS RAF1
44 11.71 EGFR HRAS KRAS RAF1
45 11.7 EGFR HRAS KRAS RAF1 TP53
46 11.69 HRAS RAF1 TP53
47 11.68 HRAS KRAS TP53
48
Show member pathways
11.68 HRAS KRAS RAF1
49 11.63 HRAS KRAS RAF1
50
Show member pathways
11.6 EGFR HRAS RAF1

GO Terms for Lung Benign Neoplasm

Biological processes related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.89 CADM1 FHIT HRAS RAF1 TP53
2 animal organ morphogenesis GO:0009887 9.7 HRAS NKX2-1 SFTPB
3 Ras protein signal transduction GO:0007265 9.61 HRAS KRAS TP53
4 positive regulation of protein phosphorylation GO:0001934 9.56 EGFR HRAS KRAS RAF1
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.54 HRAS KRAS RAF1
6 epithelial tube branching involved in lung morphogenesis GO:0060441 9.51 KRAS NKX2-1
7 positive regulation of MAP kinase activity GO:0043406 9.5 EGFR HRAS KRAS
8 cerebral cortex cell migration GO:0021795 9.48 EGFR NKX2-1
9 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.46 EGFR TP53
10 response to isolation stress GO:0035900 9.4 HRAS KRAS
11 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:1900738 9.16 CHGA GRP
12 regulation of long-term neuronal synaptic plasticity GO:0048169 9.13 HRAS KRAS SYP
13 MAPK cascade GO:0000165 9.02 EGFR HRAS KRAS NCAM1 RAF1

Molecular functions related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.02 EGFR FHIT HRAS KRAS RAF1

Sources for Lung Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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