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LNCR1
MCID: LNG109
MIFTS: 30

Lung Cancer Susceptibility 1 (LNCR1)

Categories: Cancer diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Lung Cancer Susceptibility 1

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MalaCards integrated aliases for Lung Cancer Susceptibility 1:

Name: Lung Cancer Susceptibility 1 58 74
Lung Cancer Susceptibility 58 13
Lncr1 58

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 58 608935
UMLS 74 C1837089
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Summaries for Lung Cancer Susceptibility 1

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MalaCards based summary : Lung Cancer Susceptibility 1, also known as lung cancer susceptibility, is related to lung cancer susceptibility 5 and lung cancer susceptibility 3. An important gene associated with Lung Cancer Susceptibility 1 is LNCR1 (Lung Cancer 1). The drugs Dopamine and Nicotine have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and endothelial.

Wikipedia : 77 Lung cancer susceptibility tests suggest the probability or susceptibility an individual may have of... more...

Description from OMIM: 608935
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Related Diseases for Lung Cancer Susceptibility 1

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Diseases in the Lung Cancer Susceptibility 3 family:

Lung Cancer Susceptibility 1 Lung Cancer Susceptibility 4
Lung Cancer Susceptibility 5

Diseases related to Lung Cancer Susceptibility 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 lung cancer susceptibility 5 12.5
2 lung cancer susceptibility 3 12.3
3 lung cancer susceptibility 4 12.3
4 lung cancer 11.8
5 smoking as a quantitative trait locus 3 11.5
6 small cell cancer of the lung 10.3
7 acute insulin response 9.9
8 ataxia-telangiectasia 9.8
9 xeroderma pigmentosum, complementation group d 9.8
10 xeroderma pigmentosum, variant type 9.8
11 nasopharyngeal carcinoma 9.8
12 silicosis 9.8
13 squamous cell carcinoma 9.8
14 melanoma 9.8

Graphical network of the top 20 diseases related to Lung Cancer Susceptibility 1:



Diseases related to Lung Cancer Susceptibility 1
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Symptoms & Phenotypes for Lung Cancer Susceptibility 1

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Clinical features from OMIM:

608935
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Drugs & Therapeutics for Lung Cancer Susceptibility 1

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Drugs for Lung Cancer Susceptibility 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
2
Nicotine Approved Phase 3 54-11-5 942 89594
3
Bupropion Approved Phase 3 34841-39-9, 34911-55-2 444
4 Cytochrome P-450 Enzyme Inhibitors Phase 3
5 Dopamine Agents Phase 3
6 Antidepressive Agents Phase 3
7 Neurotransmitter Uptake Inhibitors Phase 3
8 Peripheral Nervous System Agents Phase 3
9 Cholinergic Agents Phase 3
10 Antidepressive Agents, Second-Generation Phase 3
11 Autonomic Agents Phase 3
12 Psychotropic Drugs Phase 3
13 Neurotransmitter Agents Phase 3
14 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
15 Dopamine Uptake Inhibitors Phase 3
16 Nicotinic Agonists Phase 3
17 Central Nervous System Stimulants Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 S0002 - A Program to Quit Smoking With or Without Bupropion in Treating Patients With Stage I or II Non-Small Cell Lung Cancer Who Have Undergone Surgery Terminated NCT00032084 Phase 3 bupropion hydrochloride;nicotine
2 The Correlation Between Lung Cancer Susceptibility, Drug Response and Genetic Polymorphism Unknown status NCT01280448
3 Studying Patterns, Causes, and Control of Disease in Patients With Lung Cancer in the North Trent (England) Region Unknown status NCT00693836
4 Effect of Lung Cancer Diagnoses on Family Behaviors Completed NCT01862770

Search NIH Clinical Center for Lung Cancer Susceptibility 1

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Genetic Tests for Lung Cancer Susceptibility 1

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Anatomical Context for Lung Cancer Susceptibility 1

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MalaCards organs/tissues related to Lung Cancer Susceptibility 1:

42
Lung, Testes, Endothelial
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Publications for Lung Cancer Susceptibility 1

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Articles related to Lung Cancer Susceptibility 1:

(show top 50) (show all 241)
# Title Authors Year
1
Integrative system genetic analysis reveals mRNA-lncRNA network associated with mouse spontaneous lung cancer susceptibility. ( 30719228 )
2019
2
Genome-wide analysis of expression quantitative trait loci identified potential lung cancer susceptibility variants among Asian populations. ( 30689816 )
2019
3
Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci. ( 30590402 )
2018
4
Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung. ( 30604855 )
2018
5
Correction: Lung cancer susceptibility from GSTM1 deletion and air pollution with smoking status: a meta-prediction of worldwide populations. ( 30546841 )
2018
6
XPG polymorphisms and their association with lung cancer susceptibility, overall survival and response in North Indian patients treated with platinum-based doublet chemotherapy. ( 30522358 )
2018
7
Genetic variants in lncRNA HOTAIR are associated with lung cancer susceptibility in a Chinese Han population in China: a case-control study. ( 30464618 )
2018
8
Lung cancer susceptibility from GSTM1 deletion and air pollution with smoking status: a meta-prediction of worldwide populations. ( 30123431 )
2018
9
Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes. ( 29193083 )
2018
10
Inflammatory Gene Polymorphisms in Lung Cancer Susceptibility. ( 29408308 )
2018
11
Association of XPA Polymorphisms Towards Lung Cancer Susceptibility and its Predictive Role in Overall Survival of North Indians. ( 29516319 )
2018
12
Combining ctnnb1 genetic variability with epidemiologic factors to predict lung cancer susceptibility. ( 29562493 )
2018
13
CHL1 gene polymorphisms increase lung cancer susceptibility. ( 29568376 )
2018
14
CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population. ( 29609626 )
2018
15
Heritable Germline Variation and Lung Cancer Susceptibility: One Size Does not Fit All. ( 29703536 )
2018
16
XPF polymorphism toward lung cancer susceptibility and survival in patients treated with platinum-based chemotherapy. ( 29741112 )
2018
17
A meta-analytic review of the association between two common SNPs in miRNAs and lung cancer susceptibility. ( 29750042 )
2018
18
Role of Sequence Variations in AhR Gene Towards Modulating Smoking Induced Lung Cancer Susceptibility in North Indian Population: A Multiple Interaction Analysis. ( 29755293 )
2018
19
Fine mapping in TERT-CLPTM1L region identified three independent lung cancer susceptibility signals: A large-scale multi-ethnic population study. ( 29809284 )
2018
20
CYP2E1 Rsa Ι/Pst Ι polymorphism and lung cancer susceptibility: A meta-analysis involving 10,947 subjects. ( 29924497 )
2018
21
rs401681 and rs402710 confer lung cancer susceptibility by regulating TERT expression instead of CLPTM1L in East Asian populations. ( 29939218 )
2018
22
Effect of HOTAIR rs12826786 and rs1899663 polymorphisms on lung cancer susceptibility and clinicopathological characteristics in a turkish population: a hospital-based case-control study. ( 29974853 )
2018
23
Functional miRNA variants affect lung cancer susceptibility and platinum-based chemotherapy response. ( 30069329 )
2018
24
Association Between Long Noncoding RNA MEG3 Polymorphisms and Lung Cancer Susceptibility in Chinese Northeast Population. ( 30113224 )
2018
25
The Contribution of MMP-7 Promoter Polymorphisms to Taiwan Lung Cancer Susceptibility. ( 30275186 )
2018
26
The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population. ( 28423585 )
2017
27
A meta-analysis of the relationship between ataxia-telangiectasia mutated gene polymorphisms and lung cancer susceptibility. ( 28756982 )
2017
28
Fine mapping of chromosome 5p15.33 identifies novel lung cancer susceptibility loci in Han Chinese. ( 28335076 )
2017
29
Association of<i>HMGB1</i>Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects. ( 29104475 )
2017
30
Xeroderma pigmentosum complementation group D polymorphism toward lung cancer susceptibility survival and response in patients treated with platinum chemotherapy. ( 29035087 )
2017
31
RETRACTED: Association of Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism With Lung Cancer Susceptibility. ( 26755750 )
2017
32
Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers. ( 28092948 )
2017
33
Genetic variations in cancer-related significantly mutated genes and lung cancer susceptibility. ( 28383694 )
2017
34
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. ( 28604730 )
2017
35
Polymorphisms of -800G/A and +915G/C in TGF-β1 gene and lung cancer susceptibility. ( 28693227 )
2017
36
Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males. ( 28789383 )
2017
37
Genetic variation at the microRNA binding site of CAV1 gene is associated with lung cancer susceptibility. ( 29190968 )
2017
38
Association between ATM gene polymorphisms, lung cancer susceptibility and radiation-induced pneumonitis: a meta-analysis. ( 29246212 )
2017
39
NQO1 C609T polymorphism and lung cancer susceptibility: Evidence from a comprehensive meta-analysis. ( 29254245 )
2017
40
High-order gene interactions between the genetic polymorphisms in Wnt and AhR pathway in modulating lung cancer susceptibility. ( 29749862 )
2017
41
Analyzing the association between XRCC1 c.1804C&amp;gt;A genetic variant and lung cancer susceptibility in the Chinese population. ( 27323144 )
2016
42
Associations of Insulin and IGFBP-3 with Lung Cancer Susceptibility in Current Smokers. ( 27071409 )
2016
43
A polymorphic minisatellite region of BORIS regulates gene expression and its rare variants correlate with lung cancer susceptibility. ( 27416782 )
2016
44
Clinical Significance of Long Non-Coding RNA CASC8 rs10505477 Polymorphism in Lung Cancer Susceptibility, Platinum-Based Chemotherapy Response, and Toxicity. ( 27249003 )
2016
45
Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus. ( 26013599 )
2016
46
Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci. ( 26590902 )
2016
47
Association of well-characterized lung cancer lncRNA polymorphisms with lung cancer susceptibility and platinum-based chemotherapy response. ( 26729200 )
2016
48
Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. ( 26732429 )
2016
49
Gene by Environment Interaction Linking the Chromosome 15q25 Locus with Cigarette Consumption and Lung Cancer Susceptibility--Are African American Affected Differently?--Authors' Reply. ( 26981563 )
2016
50
Gene by Environment Interaction Linking the Chromosome 15q25 Locus With Cigarette Consumption and Lung Cancer Susceptibility--Are African American Affected Differently? ( 27014742 )
2016
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Variations for Lung Cancer Susceptibility 1

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Expression for Lung Cancer Susceptibility 1

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Search GEO for disease gene expression data for Lung Cancer Susceptibility 1.
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Pathways for Lung Cancer Susceptibility 1

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GO Terms for Lung Cancer Susceptibility 1

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Sources for Lung Cancer Susceptibility 1

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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