MCID: LNG001
MIFTS: 31

Lung Clear Cell Carcinoma

Categories: Cancer diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Lung Clear Cell Carcinoma

MalaCards integrated aliases for Lung Clear Cell Carcinoma:

Name: Lung Clear Cell Carcinoma 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:7267
SNOMED-CT 68 254630009
UMLS 71 C0345959

Summaries for Lung Clear Cell Carcinoma

MalaCards based summary: Lung Clear Cell Carcinoma is related to laryngeal adenoid cystic carcinoma and inverted transitional papilloma. An important gene associated with Lung Clear Cell Carcinoma is NEK8 (NIMA Related Kinase 8), and among its related pathways/superpathways are Keratinization and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include lung, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and mortality/aging

Related Diseases for Lung Clear Cell Carcinoma

Diseases in the Lung Large Cell Carcinoma family:

Small Cell Cancer of the Lung Lung Clear Cell Carcinoma

Diseases related to Lung Clear Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 292)
# Related Disease Score Top Affiliating Genes
1 laryngeal adenoid cystic carcinoma 10.4 KRT7 KRT5
2 inverted transitional papilloma 10.4 KRT7 KRT5
3 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
4 ceruminoma 10.4 KRT7 KRT5
5 subareolar duct papillomatosis 10.4 KRT7 KRT5
6 prostatic urethral cancer 10.4 KRT7 KRT5
7 cutaneous mucoepidermoid carcinoma 10.4 KRT7 KRT5
8 nipple benign neoplasm 10.4 KRT7 KRT5
9 malignant spiradenoma 10.4 KRT7 KRT5
10 spiradenoma 10.4 KRT7 KRT5
11 vulvar sebaceous carcinoma 10.4 KRT7 KRT5
12 rete testis neoplasm 10.4 KRT7 KRT5
13 adenosquamous gallbladder carcinoma 10.4 KRT7 KRT5
14 endometrial squamous cell carcinoma 10.4 KRT7 KRT5
15 rectum squamous cell carcinoma 10.4 KRT7 KRT5
16 rete testis adenocarcinoma 10.4 KRT7 KRT5
17 necrotizing sialometaplasia 10.4 KRT7 KRT5
18 breast mucoepidermoid carcinoma 10.3 KRT7 KRT5
19 malignant biphasic mesothelioma 10.3 KRT7 KRT5
20 papillary squamous carcinoma 10.3 KRT7 KRT5
21 nodular hidradenoma 10.3 KRT7 KRT5
22 hidradenoma 10.3 KRT7 KRT5
23 benign breast adenomyoepithelioma 10.3 KRT7 KRT5
24 breast adenomyoepithelioma 10.3 KRT7 KRT5
25 male urethral cancer 10.3 KRT7 KRT5
26 vulvar apocrine adenocarcinoma 10.3 KRT7 KRT5
27 apocrine adenocarcinoma 10.3 KRT7 KRT5
28 ceruminous adenocarcinoma 10.3 KRT7 KRT5
29 malignant acrospiroma 10.3 KRT7 KRT5
30 breast myoepithelial neoplasm 10.3 KRT7 KRT5
31 sublingual gland adenoid cystic carcinoma 10.3 KRT7 KRT5
32 gastric squamous cell carcinoma 10.3 KRT7 KRT5
33 eccrine adenocarcinoma 10.3 KRT7 KRT5
34 bile duct mucoepidermoid carcinoma 10.3 KRT7 KRT5
35 odontoma 10.3 KRT5 KRT18
36 sublingual gland cancer 10.3 KRT7 KRT5
37 nephrogenic adenoma of the urethra 10.3 KRT7 KRT5
38 clear cell hidradenoma 10.3 KRT7 KRT5
39 breast metaplastic carcinoma 10.3 KRT7 KRT5
40 metatypical basal cell carcinoma 10.3 KRT7 KRT5
41 breast mucinous carcinoma 10.3 KRT7 KRT5
42 balloon cell malignant melanoma 10.3 KRT7 KRT5
43 pericardial mesothelioma 10.3 KRT7 KRT5
44 malignant syringoma 10.3 KRT7 KRT5
45 breast secretory carcinoma 10.3 KRT7 KRT5
46 breast adenoid cystic carcinoma 10.3 KRT7 KRT5
47 pericardium cancer 10.3 KRT7 KRT5
48 syringocystadenoma papilliferum 10.3 KRT7 KRT5
49 acantholytic acanthoma 10.3 DSC3 DSC2
50 external ear carcinoma 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Lung Clear Cell Carcinoma:



Diseases related to Lung Clear Cell Carcinoma

Symptoms & Phenotypes for Lung Clear Cell Carcinoma

GenomeRNAi Phenotypes related to Lung Clear Cell Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.62 MSH6 NEK8

MGI Mouse Phenotypes related to Lung Clear Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.47 CHGA DSC2 DSC3 HAMP HCK KRT18
2 neoplasm MP:0002006 9.43 HCK KRT18 MSH2 MSH6 NKX2-1 PMS2

Drugs & Therapeutics for Lung Clear Cell Carcinoma

Search Clinical Trials, NIH Clinical Center for Lung Clear Cell Carcinoma

Genetic Tests for Lung Clear Cell Carcinoma

Anatomical Context for Lung Clear Cell Carcinoma

Organs/tissues related to Lung Clear Cell Carcinoma:

MalaCards : Lung

Publications for Lung Clear Cell Carcinoma

Variations for Lung Clear Cell Carcinoma

Cosmic variations for Lung Clear Cell Carcinoma:

8 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM102042323 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8009A>G p.? 16:72958974-72958974 2
2 COSM87291734 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 2
3 COSM102040476 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8037G>T p.? 16:72959002-72959002 2
4 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 2
5 COSM87290218 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 2
6 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 2
7 COSM126973051 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.770C>T p.P257L 11:102229729-102229729 2
8 COSM145028029 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1154C>T p.P385L 11:102229729-102229729 2
9 COSM128452039 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 2
10 COSM85237448 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1304C>T p.P435L 11:102229729-102229729 2
11 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 2
12 COSM127997731 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1256C>T p.P419L 11:102229729-102229729 2
13 COSM133274224 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1268C>T p.P423L 11:102229729-102229729 2
14 COSM90948266 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1202C>T p.P401L 11:102229729-102229729 2
15 COSM108017622 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 2
16 COSM95166535 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 2
17 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 2
18 COSM105839764 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 2
19 COSM106337415 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 2
20 COSM103711109 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1036A>C p.I346L 22:41653558-41653558 2
21 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 2
22 COSM134125623 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1114A>G p.M372V 19:43546970-43546970 2
23 COSM100781761 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.724A>T p.K242* 11:32392044-32392044 2
24 COSM111539040 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 2
25 COSM149728755 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 2
26 COSM130518653 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.673A>T p.K225* 11:32392044-32392044 2
27 COSM113475703 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 2
28 COSM111529696 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 2
29 COSM113484991 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 2
30 COSM147414475 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 2
31 COSM149739953 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 2
32 COSM148580942 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 2
33 COSM148593279 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 2
34 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 2
35 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 2
36 COSM147426277 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 2
37 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 2
38 COSM104050903 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 2
39 COSM105123686 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 2
40 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 2
41 COSM102763785 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 2
42 COSM99767946 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 2
43 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 2
44 COSM121848752 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 2
45 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 2
46 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 2
47 COSM99795256 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 2
48 COSM143996084 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1620C>G p.F540L 19:4947122-4947122 2
49 COSM143964403 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1428C>G p.F476L 19:4947122-4947122 2
50 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 2

Expression for Lung Clear Cell Carcinoma

Search GEO for disease gene expression data for Lung Clear Cell Carcinoma.

Pathways for Lung Clear Cell Carcinoma

Pathways related to Lung Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.89 KRT7 KRT5 KRT18 DSC3 DSC2
2 10.26 PMS2 MSH6 MSH2

GO Terms for Lung Clear Cell Carcinoma

Cellular components related to Lung Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 9.13 PMS2 MSH2
2 MutSalpha complex GO:0032301 8.92 MSH6 MSH2

Biological processes related to Lung Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of helicase activity GO:0051096 9.62 MSH6 MSH2
2 somatic recombination of immunoglobulin gene segments GO:0016447 9.46 MSH6 MSH2
3 maintenance of DNA repeat elements GO:0043570 9.43 MSH6 MSH2
4 mismatch repair GO:0006298 9.43 PMS2 MSH6 MSH2
5 somatic hypermutation of immunoglobulin genes GO:0016446 9.1 PMS2 MSH6 MSH2

Molecular functions related to Lung Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex binding GO:0032405 9.71 MSH6 MSH2
2 oxidized purine DNA binding GO:0032357 9.67 MSH6 MSH2
3 guanine/thymine mispair binding GO:0032137 9.62 MSH6 MSH2
4 single guanine insertion binding GO:0032142 9.56 MSH6 MSH2
5 single thymine insertion binding GO:0032143 9.46 MSH6 MSH2
6 ATP-dependent DNA damage sensor activity GO:0140664 9.43 PMS2 MSH6 MSH2
7 mismatched DNA binding GO:0030983 9.02 PMS2 MSH6 MSH2

Sources for Lung Clear Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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