MCID: LNG001
MIFTS: 29

Lung Clear Cell Carcinoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Lung Clear Cell Carcinoma

MalaCards integrated aliases for Lung Clear Cell Carcinoma:

Name: Lung Clear Cell Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:7267
UMLS 71 C0345959

Summaries for Lung Clear Cell Carcinoma

MalaCards based summary : Lung Clear Cell Carcinoma is related to odontoma and gallbladder small cell carcinoma. An important gene associated with Lung Clear Cell Carcinoma is NEK8 (NIMA Related Kinase 8), and among its related pathways/superpathways are Keratinization and Hematopoietic Stem Cell Differentiation. Affiliated tissues include lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Lung Clear Cell Carcinoma

Diseases in the Lung Large Cell Carcinoma family:

Small Cell Cancer of the Lung Lung Clear Cell Carcinoma

Diseases related to Lung Clear Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 odontoma 10.4 KRT5 KRT18
2 gallbladder small cell carcinoma 10.4 NEK8 KRT7
3 proliferating trichilemmal cyst 10.4 KRT7 KRT18
4 ureter squamous cell carcinoma 10.3 KRT7 KRT5
5 intrahepatic gall duct cancer 10.3 KRT7 KRT18
6 inverted transitional papilloma 10.3 KRT7 KRT5
7 ureter adenocarcinoma 10.3 KRT7 KRT5
8 ceruminoma 10.3 KRT7 KRT5
9 malignant acrospiroma 10.3 KRT7 KRT5
10 microinvasive cervical squamous cell carcinoma 10.3 KRT7 KRT5
11 subareolar duct papillomatosis 10.3 KRT7 KRT5
12 cutaneous mucoepidermoid carcinoma 10.3 KRT7 KRT5
13 nipple benign neoplasm 10.3 KRT7 KRT5
14 benign breast adenomyoepithelioma 10.3 KRT7 KRT5
15 auditory system benign neoplasm 10.3 KRT7 KRT5
16 ceruminous adenocarcinoma 10.3 KRT7 KRT5
17 eccrine adenocarcinoma 10.3 KRT7 KRT5
18 external ear carcinoma 10.3 KRT7 KRT5
19 vulvar apocrine adenocarcinoma 10.3 KRT7 KRT5
20 apocrine adenocarcinoma 10.3 KRT7 KRT5
21 middle ear adenoma 10.3 KRT7 KRT5
22 warthin tumor 10.3 KRT7 KRT18
23 gastric squamous cell carcinoma 10.3 KRT7 KRT5
24 necrotizing sialometaplasia 10.3 KRT7 KRT5
25 sensory organ benign neoplasm 10.3 KRT7 KRT5
26 bile duct mucoepidermoid carcinoma 10.3 KRT7 KRT5
27 breast mucinous carcinoma 10.3 KRT7 KRT5
28 clear cell hidradenoma 10.3 KRT7 KRT5
29 hidradenoma 10.3 KRT7 KRT5
30 middle ear adenocarcinoma 10.3 KRT7 KRT5
31 malignant biphasic mesothelioma 10.3 KRT7 KRT5
32 benign mesothelioma 10.3 KRT7 KRT5
33 pericardium cancer 10.3 KRT7 KRT5
34 mucinous tubular and spindle renal cell carcinoma 10.3 KRT7 KRT18
35 eccrine sweat gland cancer 10.3 KRT7 KRT5
36 sweat gland cancer 10.3 KRT7 KRT5
37 papillary squamous carcinoma 10.3 KRT7 KRT5
38 large cell acanthoma 10.3 KRT7 KRT5
39 epithelioid trophoblastic tumor 10.3 KRT7 KRT18
40 balloon cell malignant melanoma 10.3 KRT7 KRT5
41 nephrogenic adenoma of the urethra 10.3 KRT7 KRT5
42 cystadenofibroma 10.3 KRT7 KRT5
43 eccrine acrospiroma 10.3 KRT7 KRT5
44 liver leiomyosarcoma 10.3 KRT7 KRT5
45 eccrine sweat gland neoplasm 10.3 KRT7 KRT5
46 solid adenocarcinoma with mucin production 10.3 KRT7 KRT5
47 thymus clear cell carcinoma 10.3 KRT7 KRT5
48 eccrine porocarcinoma 10.3 KRT7 KRT5
49 eccrine papillary adenocarcinoma 10.3 KRT7 KRT5
50 nasal cavity olfactory neuroblastoma 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Lung Clear Cell Carcinoma:



Diseases related to Lung Clear Cell Carcinoma

Symptoms & Phenotypes for Lung Clear Cell Carcinoma

GenomeRNAi Phenotypes related to Lung Clear Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.36 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.36 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.36 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.36 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.36 KRT18
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.36 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.36 KRT18
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.36 KRT18 KRT5 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.36 KRT18
10 Decreased influenza A/WSN/33 replication GR00195-A-1 9.13 IL1A NEK8 SERPINA1

Drugs & Therapeutics for Lung Clear Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Clear Cell Carcinoma

Genetic Tests for Lung Clear Cell Carcinoma

Anatomical Context for Lung Clear Cell Carcinoma

MalaCards organs/tissues related to Lung Clear Cell Carcinoma:

40
Lung

Publications for Lung Clear Cell Carcinoma

Variations for Lung Clear Cell Carcinoma

Cosmic variations for Lung Clear Cell Carcinoma:

9 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
2 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
3 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 6
4 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
5 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 6
6 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
7 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
8 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 6
9 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 6
10 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
11 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
12 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 6
13 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 6
14 COSM127070824 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 6
15 COSM127059821 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 6
16 COSM85195038 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 6
17 COSM130300868 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 6
18 COSM131090496 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 6
19 COSM131094722 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 6
20 COSM131094002 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 6
21 COSM87049256 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 6
22 COSM85721789 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 6
23 COSM90140992 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 6
24 COSM90145840 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 6
25 COSM87090089 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 6
26 COSM87898991 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 6
27 COSM87901497 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 6
28 COSM87935416 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 6
29 COSM87904420 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 6
30 COSM87898444 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 6
31 COSM87906107 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 6
32 COSM87909792 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 6
33 COSM87940740 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 6
34 COSM87899785 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 6
35 COSM87902162 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 6
36 COSM87915599 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 6
37 COSM87897914 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 6
38 COSM87899377 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 6
39 COSM87900565 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 6
40 COSM87918616 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 6
41 COSM87897711 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 6
42 COSM87900157 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 6
43 COSM87942817 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 6
44 COSM87903076 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 6
45 COSM87898836 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 6
46 COSM87898881 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 6
47 COSM150205149 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 6
48 COSM85378871 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 6
49 COSM90180942 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 6
50 COSM90180404 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 6

Expression for Lung Clear Cell Carcinoma

Search GEO for disease gene expression data for Lung Clear Cell Carcinoma.

Pathways for Lung Clear Cell Carcinoma

Pathways related to Lung Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 KRT7 KRT5 KRT18
2 10.84 IL1A EPO
3
Show member pathways
10.83 KRT7 KRT5 KRT18

GO Terms for Lung Clear Cell Carcinoma

Cellular components related to Lung Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.43 SERPINA1 PSMB8 MB KRT7 KRT5 KRT18
2 intermediate filament GO:0005882 9.33 KRT7 KRT5 KRT18
3 keratin filament GO:0045095 8.8 KRT7 KRT5 KRT18

Biological processes related to Lung Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.43 KRT7 KRT5 KRT18
2 response to vitamin A GO:0033189 9.16 HAMP EPO
3 cornification GO:0070268 9.13 KRT7 KRT5 KRT18
4 acute-phase response GO:0006953 8.8 SERPINA1 HAMP EPO

Sources for Lung Clear Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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