MCID: LNG002
MIFTS: 34

Lung Combined Large Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Neuronal diseases, Respiratory diseases
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Aliases & Classifications for Lung Combined Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Lung Combined Large Cell Neuroendocrine Carcinoma:

Name: Lung Combined Large Cell Neuroendocrine Carcinoma 11 14
Pulmonary Combined Large Cell Neuroendocrine Carcinoma 11
Combined Large Cell Neuroendocrine Carcinoma of Lung 11
Combined Large Cell Lung Neuroendocrine Carcinoma 71

Classifications:



External Ids:

Disease Ontology 11 DOID:7207
NCIt 49 C7267
UMLS 71 C1333122

Summaries for Lung Combined Large Cell Neuroendocrine Carcinoma

MalaCards based summary: Lung Combined Large Cell Neuroendocrine Carcinoma, also known as pulmonary combined large cell neuroendocrine carcinoma, is related to small cell cancer of the lung and neuroendocrine carcinoma, and has symptoms including fever, hemoptysis and dyspnea. An important gene associated with Lung Combined Large Cell Neuroendocrine Carcinoma is KLC1 (Kinesin Light Chain 1), and among its related pathways/superpathways are Signaling by ALK in cancer and Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include lung and bone, and related phenotype is Decreased substrate adherent cell growth.

Related Diseases for Lung Combined Large Cell Neuroendocrine Carcinoma

Diseases related to Lung Combined Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 small cell cancer of the lung 30.0 SYP ENO2 CHGA
2 neuroendocrine carcinoma 30.0 SYP KRT19 ENO2 CHGA
3 small cell carcinoma 29.9 SYP ENO2 CHGA ALK
4 pulmonary large cell neuroendocrine carcinoma 29.9 SYP ENO2 CHGA ALK
5 large cell neuroendocrine carcinoma 29.8 SYP ROS1 ENO2 CHGA ALK
6 neuroendocrine tumor 29.7 SYP KRT19 ENO2 CHGA
7 nephroma 10.3 EML4 ALK
8 signet ring lung adenocarcinoma 10.3 EML4 ALK
9 epithelioid inflammatory myofibroblastic sarcoma 10.3 EML4 ALK
10 lung carcinoma in situ 10.3 EML4 ALK
11 pulmonary adenocarcinoma in situ 10.3 EML4 ALK
12 main bronchus cancer 10.3 ROS1 ALK
13 pulmonary plasma cell granuloma 10.3 ROS1 ALK
14 malignant giant cell tumor of the tendon sheath 10.3 ROS1 ALK
15 mucinous lung adenocarcinoma 10.2 ROS1 ALK
16 vulvar keratinizing squamous cell carcinoma 10.2 KRT19 ALK
17 lymphangitis 10.2 ROS1 ALK
18 heart leiomyosarcoma 10.2 KRT19 ALK
19 adenocarcinoma in situ 10.2 ROS1 ALK
20 pancreas lymphoma 10.2 SYP CHGA
21 vaginal tubulovillous adenoma 10.2 SYP CHGA
22 mixed ductal-endocrine carcinoma 10.2 SYP CHGA
23 vulvar eccrine porocarcinoma 10.2 SYP CHGA
24 cervical large cell neuroendocrine carcinoma 10.2 SYP CHGA
25 duodenal benign neoplasm 10.2 SYP CHGA
26 spitzoid melanoma 10.2 ROS1 ALK
27 papillary thymic adenocarcinoma 10.2 SYP CHGA
28 breast papillary carcinoma 10.2 SYP CHGA
29 gastric gastrinoma 10.2 SYP CHGA
30 ectopic cushing syndrome 10.2 SYP CHGA
31 binswanger's disease 10.2 SYP CHGA
32 benign perivascular tumor 10.2 SYP CHGA
33 gastrointestinal neuroendocrine benign tumor 10.2 SYP CHGA
34 duodenal gastrinoma 10.2 SYP CHGA
35 glomangioma 10.2 SYP CHGA
36 extra-adrenal pheochromocytoma 10.2 SYP CHGA
37 pancreatic gastrinoma 10.2 SYP CHGA
38 ovary leiomyosarcoma 10.2 SYP CHGA
39 benign ileal neoplasm 10.2 SYP CHGA
40 vaginal adenoma 10.2 SYP CHGA
41 appendix adenocarcinoma 10.2 SYP CHGA
42 thymus large cell carcinoma 10.2 SYP CHGA
43 gastric neuroendocrine neoplasm 10.2 SYP CHGA
44 vaginal benign neoplasm 10.2 SYP CHGA
45 solid adenocarcinoma with mucin production 10.2 ROS1 CHGA
46 laryngeal small cell carcinoma 10.2 SYP CHGA
47 mucinous cystadenofibroma 10.2 SYP GATA3
48 ovarian germ cell teratoma 10.2 SYP KRT19
49 esophageal neuroendocrine tumor 10.2 SYP CHGA
50 pancreatic serous cystic neoplasm 10.2 KRT19 CHGA

Graphical network of the top 20 diseases related to Lung Combined Large Cell Neuroendocrine Carcinoma:



Diseases related to Lung Combined Large Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Lung Combined Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Lung Combined Large Cell Neuroendocrine Carcinoma:


fever; hemoptysis; dyspnea; coughing

GenomeRNAi Phenotypes related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.1 ROS1
2 Decreased substrate adherent cell growth GR00193-A-2 9.1 ALK BMPR1A ROS1
3 Decreased substrate adherent cell growth GR00193-A-3 9.1 BMPR1A
4 Decreased substrate adherent cell growth GR00193-A-4 9.1 BMPR1A

Drugs & Therapeutics for Lung Combined Large Cell Neuroendocrine Carcinoma

Search Clinical Trials, NIH Clinical Center for Lung Combined Large Cell Neuroendocrine Carcinoma

Genetic Tests for Lung Combined Large Cell Neuroendocrine Carcinoma

Anatomical Context for Lung Combined Large Cell Neuroendocrine Carcinoma

Organs/tissues related to Lung Combined Large Cell Neuroendocrine Carcinoma:

MalaCards : Lung, Bone

Publications for Lung Combined Large Cell Neuroendocrine Carcinoma

Articles related to Lung Combined Large Cell Neuroendocrine Carcinoma:

# Title Authors PMID Year
1
A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib. 62
35200571 2022
2
Comparative Study of Pulmonary Combined Large-Cell Neuroendocrine Carcinoma and Combined Small-Cell Carcinoma in Surgically Resected High-Grade Neuroendocrine Tumors of the Lung. 62
34631540 2021
3
Long-term survivor of pulmonary combined large cell neuroendocrine carcinoma treated with nivolumab. 62
32379390 2020

Variations for Lung Combined Large Cell Neuroendocrine Carcinoma

Cosmic variations for Lung Combined Large Cell Neuroendocrine Carcinoma:

8 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM102042323 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8009A>G p.? 16:72958974-72958974 7
2 COSM87291734 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 7
3 COSM102040476 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8037G>T p.? 16:72959002-72959002 7
4 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 7
5 COSM87290218 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 7
6 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 7
7 COSM126973051 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.770C>T p.P257L 11:102229729-102229729 7
8 COSM145028029 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1154C>T p.P385L 11:102229729-102229729 7
9 COSM128452039 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 7
10 COSM85237448 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1304C>T p.P435L 11:102229729-102229729 7
11 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 7
12 COSM127997731 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1256C>T p.P419L 11:102229729-102229729 7
13 COSM133274224 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1268C>T p.P423L 11:102229729-102229729 7
14 COSM90948266 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1202C>T p.P401L 11:102229729-102229729 7
15 COSM108017622 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 7
16 COSM95166535 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 7
17 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 7
18 COSM105839764 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 7
19 COSM106337415 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 7
20 COSM103711109 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1036A>C p.I346L 22:41653558-41653558 7
21 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 7
22 COSM134125623 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1114A>G p.M372V 19:43546970-43546970 7
23 COSM100781761 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.724A>T p.K242* 11:32392044-32392044 7
24 COSM111539040 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 7
25 COSM149728755 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 7
26 COSM130518653 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.673A>T p.K225* 11:32392044-32392044 7
27 COSM113475703 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 7
28 COSM111529696 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 7
29 COSM113484991 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 7
30 COSM147414475 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 7
31 COSM149739953 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 7
32 COSM148580942 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 7
33 COSM148593279 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 7
34 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 7
35 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 7
36 COSM147426277 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 7
37 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 7
38 COSM104050903 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 7
39 COSM105123686 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 7
40 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 7
41 COSM102763785 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 7
42 COSM99767946 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 7
43 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 7
44 COSM121848752 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 7
45 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 7
46 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 7
47 COSM99795256 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 7
48 COSM143996084 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1620C>G p.F540L 19:4947122-4947122 7
49 COSM143964403 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1428C>G p.F476L 19:4947122-4947122 7
50 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 7

Expression for Lung Combined Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Lung Combined Large Cell Neuroendocrine Carcinoma.

Pathways for Lung Combined Large Cell Neuroendocrine Carcinoma

Pathways related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.07 KLC1 KIF5B EML4 ALK
2 10.71 ROS1 EML4 ALK
3 10.2 KLC1 KIF5B

GO Terms for Lung Combined Large Cell Neuroendocrine Carcinoma

Cellular components related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.5 MTUS2 MTUS1 KRT19 KLC1 KIF5B EML4
2 microtubule GO:0005874 9.28 MTUS2 MTUS1 KLC1 KIF5B EML4

Biological processes related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cardiac right ventricle morphogenesis GO:0003215 9.26 GATA3 BMPR1A
2 stress granule disassembly GO:0035617 8.92 KLC1 KIF5B

Molecular functions related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule binding GO:0008017 9.23 MTUS2 MTUS1 KIF5B EML4

Sources for Lung Combined Large Cell Neuroendocrine Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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