Lung Combined Large Cell Neuroendocrine Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lung Combined Large Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Lung Combined Large Cell Neuroendocrine Carcinoma:

Name: Lung Combined Large Cell Neuroendocrine Carcinoma ¹¹ ¹⁴

Pulmonary Combined Large Cell Neuroendocrine Carcinoma ¹¹

Combined Large Cell Neuroendocrine Carcinoma of Lung ¹¹

Combined Large Cell Lung Neuroendocrine Carcinoma ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:7207

NCIt ⁴⁹ C7267

UMLS ⁷¹ C1333122

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Summaries for Lung Combined Large Cell Neuroendocrine Carcinoma

MalaCards based summary: Lung Combined Large Cell Neuroendocrine Carcinoma, also known as pulmonary combined large cell neuroendocrine carcinoma, is related to small cell cancer of the lung and neuroendocrine carcinoma, and has symptoms including fever, hemoptysis and dyspnea. An important gene associated with Lung Combined Large Cell Neuroendocrine Carcinoma is KLC1 (Kinesin Light Chain 1), and among its related pathways/superpathways are Signaling by ALK in cancer and Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include lung and bone, and related phenotype is Decreased substrate adherent cell growth.

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Related Diseases for Lung Combined Large Cell Neuroendocrine Carcinoma

Diseases related to Lung Combined Large Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)

#	Related Disease	Score	Top Affiliating Genes
1	small cell cancer of the lung	30.0	SYP ENO2 CHGA
2	neuroendocrine carcinoma	30.0	SYP KRT19 ENO2 CHGA
3	small cell carcinoma	29.9	SYP ENO2 CHGA ALK
4	pulmonary large cell neuroendocrine carcinoma	29.9	SYP ENO2 CHGA ALK
5	large cell neuroendocrine carcinoma	29.8	SYP ROS1 ENO2 CHGA ALK
6	neuroendocrine tumor	29.7	SYP KRT19 ENO2 CHGA
7	nephroma	10.3	EML4 ALK
8	signet ring lung adenocarcinoma	10.3	EML4 ALK
9	epithelioid inflammatory myofibroblastic sarcoma	10.3	EML4 ALK
10	lung carcinoma in situ	10.3	EML4 ALK
11	pulmonary adenocarcinoma in situ	10.3	EML4 ALK
12	main bronchus cancer	10.3	ROS1 ALK
13	pulmonary plasma cell granuloma	10.3	ROS1 ALK
14	malignant giant cell tumor of the tendon sheath	10.3	ROS1 ALK
15	mucinous lung adenocarcinoma	10.2	ROS1 ALK
16	vulvar keratinizing squamous cell carcinoma	10.2	KRT19 ALK
17	lymphangitis	10.2	ROS1 ALK
18	heart leiomyosarcoma	10.2	KRT19 ALK
19	adenocarcinoma in situ	10.2	ROS1 ALK
20	pancreas lymphoma	10.2	SYP CHGA
21	vaginal tubulovillous adenoma	10.2	SYP CHGA
22	mixed ductal-endocrine carcinoma	10.2	SYP CHGA
23	vulvar eccrine porocarcinoma	10.2	SYP CHGA
24	cervical large cell neuroendocrine carcinoma	10.2	SYP CHGA
25	duodenal benign neoplasm	10.2	SYP CHGA
26	spitzoid melanoma	10.2	ROS1 ALK
27	papillary thymic adenocarcinoma	10.2	SYP CHGA
28	breast papillary carcinoma	10.2	SYP CHGA
29	gastric gastrinoma	10.2	SYP CHGA
30	ectopic cushing syndrome	10.2	SYP CHGA
31	binswanger's disease	10.2	SYP CHGA
32	benign perivascular tumor	10.2	SYP CHGA
33	gastrointestinal neuroendocrine benign tumor	10.2	SYP CHGA
34	duodenal gastrinoma	10.2	SYP CHGA
35	glomangioma	10.2	SYP CHGA
36	extra-adrenal pheochromocytoma	10.2	SYP CHGA
37	pancreatic gastrinoma	10.2	SYP CHGA
38	ovary leiomyosarcoma	10.2	SYP CHGA
39	benign ileal neoplasm	10.2	SYP CHGA
40	vaginal adenoma	10.2	SYP CHGA
41	appendix adenocarcinoma	10.2	SYP CHGA
42	thymus large cell carcinoma	10.2	SYP CHGA
43	gastric neuroendocrine neoplasm	10.2	SYP CHGA
44	vaginal benign neoplasm	10.2	SYP CHGA
45	solid adenocarcinoma with mucin production	10.2	ROS1 CHGA
46	laryngeal small cell carcinoma	10.2	SYP CHGA
47	mucinous cystadenofibroma	10.2	SYP GATA3
48	ovarian germ cell teratoma	10.2	SYP KRT19
49	esophageal neuroendocrine tumor	10.2	SYP CHGA
50	pancreatic serous cystic neoplasm	10.2	KRT19 CHGA

Graphical network of the top 20 diseases related to Lung Combined Large Cell Neuroendocrine Carcinoma:

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Symptoms & Phenotypes for Lung Combined Large Cell Neuroendocrine Carcinoma

UMLS symptoms related to Lung Combined Large Cell Neuroendocrine Carcinoma:

fever; hemoptysis; dyspnea; coughing

GenomeRNAi Phenotypes related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-1	9.1	ROS1
2	Decreased substrate adherent cell growth	GR00193-A-2	9.1	ALK BMPR1A ROS1
3	Decreased substrate adherent cell growth	GR00193-A-3	9.1	BMPR1A
4	Decreased substrate adherent cell growth	GR00193-A-4	9.1	BMPR1A

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Drugs & Therapeutics for Lung Combined Large Cell Neuroendocrine Carcinoma

Search Clinical Trials, NIH Clinical Center for Lung Combined Large Cell Neuroendocrine Carcinoma

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Genetic Tests for Lung Combined Large Cell Neuroendocrine Carcinoma

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Anatomical Context for Lung Combined Large Cell Neuroendocrine Carcinoma

Organs/tissues related to Lung Combined Large Cell Neuroendocrine Carcinoma:

MalaCards : Lung, Bone

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Publications for Lung Combined Large Cell Neuroendocrine Carcinoma

Articles related to Lung Combined Large Cell Neuroendocrine Carcinoma:

#	Title	Authors	PMID	Year
1	A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib. ⁶²	Lim CA...Melosky B	35200571	2022
2	Comparative Study of Pulmonary Combined Large-Cell Neuroendocrine Carcinoma and Combined Small-Cell Carcinoma in Surgically Resected High-Grade Neuroendocrine Tumors of the Lung. ⁶²	Wang Y...Han B	34631540	2021
3	Long-term survivor of pulmonary combined large cell neuroendocrine carcinoma treated with nivolumab. ⁶²	Oda R...Nakanishi R	32379390	2020

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Genes for Lung Combined Large Cell Neuroendocrine Carcinoma

Genes related to Lung Combined Large Cell Neuroendocrine Carcinoma (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KLC1	Kinesin Light Chain 1	Protein Coding	4.68	DISEASES inferred ¹⁴
2	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	4.4	DISEASES inferred ¹⁴
3	EML4	EMAP Like 4	Protein Coding	4.36	DISEASES inferred ¹⁴
4	KIF5B	Kinesin Family Member 5B	Protein Coding	4.17	DISEASES inferred ¹⁴
5	BMPR1A	Bone Morphogenetic Protein Receptor Type 1A	Protein Coding	3.93	DISEASES inferred ¹⁴
6	SYP	Synaptophysin	Protein Coding	3.77	DISEASES inferred ¹⁴
7	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	3.33	DISEASES inferred ¹⁴
8	CHGA	Chromogranin A	Protein Coding	3.16	DISEASES inferred ¹⁴
9	KRT19	Keratin 19	Protein Coding	3.13	DISEASES inferred ¹⁴
10	GATA3	GATA Binding Protein 3	Protein Coding	3.02	DISEASES inferred ¹⁴
11	ENO2	Enolase 2	Protein Coding	3	DISEASES inferred ¹⁴
12	MTUS2	Microtubule Associated Scaffold Protein 2	Protein Coding	2.99	DISEASES inferred ¹⁴
13	MTUS1	Microtubule Associated Scaffold Protein 1	Protein Coding	2.98	DISEASES inferred ¹⁴

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Variations for Lung Combined Large Cell Neuroendocrine Carcinoma

Cosmic variations for Lung Combined Large Cell Neuroendocrine Carcinoma:

⁸ (show top 50) (show all 1540)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM102042323	ZFHX3	lung,NS,carcinoma,undifferentiated carcinoma	c.-23-8009A>G	p.?	16:72958974-72958974	7
2	COSM87291734	ZFHX3	lung,NS,carcinoma,undifferentiated carcinoma	c.1172A>G	p.Q391R	16:72958974-72958974	7
3	COSM102040476	ZFHX3	lung,NS,carcinoma,undifferentiated carcinoma	c.-23-8037G>T	p.?	16:72959002-72959002	7
4	COSM149314749	ZFHX3	lung,NS,carcinoma,undifferentiated carcinoma	c.1144G>T	p.G382C	16:72959002-72959002	7
5	COSM87290218	ZFHX3	lung,NS,carcinoma,undifferentiated carcinoma	c.1144G>T	p.G382C	16:72959002-72959002	7
6	COSM149318860	ZFHX3	lung,NS,carcinoma,undifferentiated carcinoma	c.1172A>G	p.Q391R	16:72958974-72958974	7
7	COSM126973051	YAP1	lung,NS,carcinoma,undifferentiated carcinoma	c.770C>T	p.P257L	11:102229729-102229729	7
8	COSM145028029	YAP1	lung,NS,carcinoma,undifferentiated carcinoma	c.1154C>T	p.P385L	11:102229729-102229729	7
9	COSM128452039	YAP1	lung,NS,carcinoma,undifferentiated carcinoma	c.1142C>T	p.P381L	11:102229729-102229729	7
10	COSM85237448	YAP1	lung,NS,carcinoma,undifferentiated carcinoma	c.1304C>T	p.P435L	11:102229729-102229729	7
11	COSM143041512	YAP1	lung,NS,carcinoma,undifferentiated carcinoma	c.1316C>T	p.P439L	11:102229729-102229729	7
12	COSM127997731	YAP1	lung,NS,carcinoma,undifferentiated carcinoma	c.1256C>T	p.P419L	11:102229729-102229729	7
13	COSM133274224	YAP1	lung,NS,carcinoma,undifferentiated carcinoma	c.1268C>T	p.P423L	11:102229729-102229729	7
14	COSM90948266	YAP1	lung,NS,carcinoma,undifferentiated carcinoma	c.1202C>T	p.P401L	11:102229729-102229729	7
15	COSM108017622	XRCC6	lung,NS,carcinoma,undifferentiated carcinoma	c.1009A>C	p.I337L	22:41653558-41653558	7
16	COSM95166535	XRCC6	lung,NS,carcinoma,undifferentiated carcinoma	c.1159A>C	p.I387L	22:41653558-41653558	7
17	COSM97230831	XRCC6	lung,NS,carcinoma,undifferentiated carcinoma	c.1159A>C	p.I387L	22:41653558-41653558	7
18	COSM105839764	XRCC6	lung,NS,carcinoma,undifferentiated carcinoma	c.1009A>C	p.I337L	22:41653558-41653558	7
19	COSM106337415	XRCC6	lung,NS,carcinoma,undifferentiated carcinoma	c.1159A>C	p.I387L	22:41653558-41653558	7
20	COSM103711109	XRCC6	lung,NS,carcinoma,undifferentiated carcinoma	c.1036A>C	p.I346L	22:41653558-41653558	7
21	COSM85312404	XRCC1	lung,NS,carcinoma,undifferentiated carcinoma	c.1207A>G	p.M403V	19:43546970-43546970	7
22	COSM134125623	XRCC1	lung,NS,carcinoma,undifferentiated carcinoma	c.1114A>G	p.M372V	19:43546970-43546970	7
23	COSM100781761	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.724A>T	p.K242*	11:32392044-32392044	7
24	COSM111539040	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.1309A>T	p.K437*	11:32392044-32392044	7
25	COSM149728755	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.437G>A	p.W146*	11:32434909-32434909	7
26	COSM130518653	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.673A>T	p.K225*	11:32392044-32392044	7
27	COSM113475703	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.437G>A	p.W146*	11:32434909-32434909	7
28	COSM111529696	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.437G>A	p.W146*	11:32434909-32434909	7
29	COSM113484991	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.1360A>T	p.K454*	11:32392044-32392044	7
30	COSM147414475	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.437G>A	p.W146*	11:32434909-32434909	7
31	COSM149739953	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.1360A>T	p.K454*	11:32392044-32392044	7
32	COSM148580942	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.437G>A	p.W146*	11:32434909-32434909	7
33	COSM148593279	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.1360A>T	p.K454*	11:32392044-32392044	7
34	COSM91372655	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.437G>A	p.W146*	11:32434909-32434909	7
35	COSM91383011	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.1360A>T	p.K454*	11:32392044-32392044	7
36	COSM147426277	WT1	lung,NS,carcinoma,undifferentiated carcinoma	c.1309A>T	p.K437*	11:32392044-32392044	7
37	COSM124478343	WNT8A	lung,NS,carcinoma,undifferentiated carcinoma	c.422G>C	p.G141A	5:138088927-138088927	7
38	COSM104050903	WNT8A	lung,NS,carcinoma,undifferentiated carcinoma	c.368G>C	p.G123A	5:138088927-138088927	7
39	COSM105123686	WNT10B	lung,NS,carcinoma,undifferentiated carcinoma	c.*288A>C	p.?	12:48966259-48966259	7
40	COSM87652733	WNT10B	lung,NS,carcinoma,undifferentiated carcinoma	c.1006A>C	p.K336Q	12:48966259-48966259	7
41	COSM102763785	WNT10B	lung,NS,carcinoma,undifferentiated carcinoma	c.*288A>C	p.?	12:48966259-48966259	7
42	COSM99767946	USP5	lung,NS,carcinoma,undifferentiated carcinoma	c.755C>T	p.T252I	12:6856877-6856877	7
43	COSM84601598	USP5	lung,NS,carcinoma,undifferentiated carcinoma	c.755C>T	p.T252I	12:6856877-6856877	7
44	COSM121848752	USP38	lung,NS,carcinoma,undifferentiated carcinoma	c.994G>C	p.A332P	4:143197868-143197868	7
45	COSM88410243	USP38	lung,NS,carcinoma,undifferentiated carcinoma	c.994G>C	p.A332P	4:143197868-143197868	7
46	COSM87541563	USP32	lung,NS,carcinoma,undifferentiated carcinoma	c.192T>A	p.I64=	17:60301699-60301699	7
47	COSM99795256	USP32	lung,NS,carcinoma,undifferentiated carcinoma	c.192T>A	p.I64=	17:60301699-60301699	7
48	COSM143996084	UHRF1	lung,NS,carcinoma,undifferentiated carcinoma	c.1620C>G	p.F540L	19:4947122-4947122	7
49	COSM143964403	UHRF1	lung,NS,carcinoma,undifferentiated carcinoma	c.1428C>G	p.F476L	19:4947122-4947122	7
50	COSM145430147	UHRF1	lung,NS,carcinoma,undifferentiated carcinoma	c.1467C>G	p.F489L	19:4947122-4947122	7

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Expression for Lung Combined Large Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Lung Combined Large Cell Neuroendocrine Carcinoma.

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Pathways for Lung Combined Large Cell Neuroendocrine Carcinoma

Pathways related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by ALK in cancer ⁶⁶ Show member pathways ALK mutants bind TKIs ⁶⁶ Nuclear events stimulated by ALK signaling in cancer ⁶⁶ Signaling by ALK fusions and activated point mutants ⁶⁶	11.07	KLC1 KIF5B EML4 ALK
2	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.71	ROS1 EML4 ALK
3	RHO GTPases activate KTN1 ⁶⁶	10.2	KLC1 KIF5B

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GO Terms for Lung Combined Large Cell Neuroendocrine Carcinoma

Cellular components related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoskeleton	GO:0005856	9.5	MTUS2 MTUS1 KRT19 KLC1 KIF5B EML4
2	microtubule	GO:0005874	9.28	MTUS2 MTUS1 KLC1 KIF5B EML4

Biological processes related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cardiac right ventricle morphogenesis	GO:0003215	9.26	GATA3 BMPR1A
2	stress granule disassembly	GO:0035617	8.92	KLC1 KIF5B

Molecular functions related to Lung Combined Large Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	microtubule binding	GO:0008017	9.23	MTUS2 MTUS1 KIF5B EML4

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Sources for Lung Combined Large Cell Neuroendocrine Carcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LNG002 MIFTS: 34	Lung Combined Large Cell Neuroendocrine Carcinoma Categories: Cancer diseases, Neuronal diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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