MCID: LNG019
MIFTS: 23

Lung Combined Type Small Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Combined Type Small Cell Carcinoma

MalaCards integrated aliases for Lung Combined Type Small Cell Carcinoma:

Name: Lung Combined Type Small Cell Carcinoma 12 15
Combined Type Small Cell Carcinoma of Lung 12
Combined Small Cell Carcinoma of the Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5421
NCIt 50 C9137
UMLS 73 C1333125

Summaries for Lung Combined Type Small Cell Carcinoma

Disease Ontology : 12 A lung small cell carcinoma that is characterized as a multiphasic lung cancer comprised of a mixture of small cell and non-small cell lung carcinoma cells.

MalaCards based summary : Lung Combined Type Small Cell Carcinoma, also known as combined type small cell carcinoma of lung, is related to small cell carcinoma and lung combined type small cell adenocarcinoma. An important gene associated with Lung Combined Type Small Cell Carcinoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include lung and skeletal muscle.

Related Diseases for Lung Combined Type Small Cell Carcinoma

Diseases related to Lung Combined Type Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 29.8 NCAM1 SYP
2 lung combined type small cell adenocarcinoma 11.1
3 desmoplastic infantile ganglioglioma 10.5 GFAP SYP
4 extraventricular neurocytoma 10.5 GFAP SYP
5 cellular ependymoma 10.5 GFAP SYP
6 gangliocytoma 10.5 GFAP SYP
7 rhabdoid meningioma 10.5 GFAP SYP
8 pilomyxoid astrocytoma 10.5 GFAP SYP
9 chordoid meningioma 10.5 GFAP SYP
10 central nervous system primitive neuroectodermal neoplasm 10.5 GFAP SYP
11 subependymal glioma 10.5 GFAP SYP
12 chiari malformation 10.5 GFAP SYP
13 dysembryoplastic neuroepithelial tumor 10.5 GFAP SYP
14 cerebral neuroblastoma 10.5 GFAP SYP
15 benign ependymoma 10.5 GFAP SYP
16 astroblastoma 10.5 GFAP SYP
17 cerebral ventricle cancer 10.5 GFAP SYP
18 cerebrum cancer 10.5 GFAP SYP
19 pineal gland cancer 10.5 GFAP SYP
20 melanotic neuroectodermal tumor 10.5 GFAP SYP
21 angiocentric glioma 10.5 GFAP SYP
22 obstructive hydrocephalus 10.5 GFAP SYP
23 supratentorial cancer 10.5 GFAP SYP
24 medulloepithelioma 10.5 GFAP SYP
25 pineocytoma 10.5 GFAP SYP
26 anaplastic ependymoma 10.5 GFAP SYP
27 childhood oligodendroglioma 10.5 GFAP SYP
28 tanycytic ependymoma 10.5 GFAP SYP
29 papillary ependymoma 10.5 GFAP SYP
30 pleomorphic xanthoastrocytoma 10.4 GFAP SYP
31 pineoblastoma 10.4 GFAP SYP
32 subependymal giant cell astrocytoma 10.4 GFAP SYP
33 papilloma of choroid plexus 10.4 GFAP SYP
34 central neurocytoma 10.4 GFAP SYP
35 binswanger's disease 10.4 GFAP SYP
36 cystic teratoma 10.4 GFAP SYP
37 cerebellar liponeurocytoma 10.4 GFAP SYP
38 cerebellopontine angle tumor 10.4 GFAP SYP
39 adult medulloblastoma 10.4 GFAP SYP
40 clear cell ependymoma 10.4 GFAP SYP
41 optic nerve glioma 10.3 GFAP SYP
42 giant cell glioblastoma 10.3 GFAP SYP
43 perivascular epithelioid cell tumor 10.3 MME SYP
44 infratentorial cancer 10.3 GFAP SYP
45 fallopian tube endometrioid adenocarcinoma 10.3 MME MYOG
46 ganglioglioma 10.3 GFAP SYP
47 myxopapillary ependymoma 10.3 GFAP NCAM1
48 atypical teratoid rhabdoid tumor 10.3 GFAP SYP
49 mixed cell type cancer 10.3 MME SYP
50 esophageal neuroendocrine tumor 10.3 NCAM1 SYP

Graphical network of the top 20 diseases related to Lung Combined Type Small Cell Carcinoma:



Diseases related to Lung Combined Type Small Cell Carcinoma

Symptoms & Phenotypes for Lung Combined Type Small Cell Carcinoma

Drugs & Therapeutics for Lung Combined Type Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Combined Type Small Cell Carcinoma

Genetic Tests for Lung Combined Type Small Cell Carcinoma

Anatomical Context for Lung Combined Type Small Cell Carcinoma

MalaCards organs/tissues related to Lung Combined Type Small Cell Carcinoma:

41
Lung, Skeletal Muscle

Publications for Lung Combined Type Small Cell Carcinoma

Articles related to Lung Combined Type Small Cell Carcinoma:

# Title Authors Year
1
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type. ( 21210145 )
2011

Variations for Lung Combined Type Small Cell Carcinoma

Cosmic variations for Lung Combined Type Small Cell Carcinoma:

9
(show top 50) (show all 5596)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM316964 ZZEF1 lung,NS,carcinoma,small cell carcinoma c.4892G>T p.G1631V 17:4059282-4059282 15
2 COSM316963 ZYG11B lung,NS,carcinoma,small cell carcinoma c.1635G>C p.M545I 1:52801968-52801968 15
3 COSM316957 ZSWIM4 lung,NS,carcinoma,small cell carcinoma c.944G>T p.R315L 19:13809152-13809152 15
4 COSM6982093 ZRSR2 lung,NS,carcinoma,small cell carcinoma c.1180G>A p.E394K 23:15822973-15822973 15
5 COSM316946 ZRANB2 lung,NS,carcinoma,small cell carcinoma c.17T>C p.F6S 1:71080979-71080979 15
6 COSM316944 ZP2 lung,NS,carcinoma,small cell carcinoma c.1608C>T p.P536P 16:21201455-21201455 15
7 COSM316937 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1024A>G p.T342A 12:133057739-133057739 15
8 COSM316935 ZNF831 lung,NS,carcinoma,small cell carcinoma c.1027G>C p.D343H 20:59192046-59192046 15
9 COSM316926 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3753G>C p.L1251L 7:89336735-89336735 15
10 COSM316923 ZNF804B lung,NS,carcinoma,small cell carcinoma c.522C>A p.P174P 7:89333504-89333504 15
11 COSM318343 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3661G>C p.A1221P 7:89336643-89336643 15
12 COSM316920 ZNF804A lung,NS,carcinoma,small cell carcinoma c.3281C>T p.S1094F 2:184938677-184938677 15
13 COSM318342 ZNF804A lung,NS,carcinoma,small cell carcinoma c.862A>T p.K288* 2:184936258-184936258 15
14 COSM316909 ZNF777 lung,NS,carcinoma,small cell carcinoma c.1998C>T p.C666C 7:149432274-149432274 15
15 COSM316903 ZNF746 lung,NS,carcinoma,small cell carcinoma c.887C>T p.A296V 7:149475432-149475432 15
16 COSM318340 ZNF711 lung,NS,carcinoma,small cell carcinoma c.113A>T p.D38V 23:85255352-85255352 15
17 COSM316902 ZNF711 lung,NS,carcinoma,small cell carcinoma c.1401G>T p.E467D 23:85270913-85270913 15
18 COSM318339 ZNF7 lung,NS,carcinoma,small cell carcinoma c.989G>C p.G330A 8:144842096-144842096 15
19 COSM316887 ZNF667 lung,NS,carcinoma,small cell carcinoma c.132G>T p.L44F 19:56460717-56460717 15
20 COSM316886 ZNF660 lung,NS,carcinoma,small cell carcinoma c.575G>A p.C192Y 3:44594768-44594768 15
21 COSM316882 ZNF653 lung,NS,carcinoma,small cell carcinoma c.808C>T p.P270S 19:11487655-11487655 15
22 COSM316883 ZNF653 lung,NS,carcinoma,small cell carcinoma c.346C>T p.R116W 19:11496163-11496163 15
23 COSM316871 ZNF638 lung,NS,carcinoma,small cell carcinoma c.1926G>A p.K642K 2:71365637-71365637 15
24 COSM316869 ZNF630 lung,NS,carcinoma,small cell carcinoma c.1534G>C p.E512Q 23:48058908-48058908 15
25 COSM316861 ZNF609 lung,NS,carcinoma,small cell carcinoma c.1497C>T p.H499H 15:64674351-64674351 15
26 COSM316860 ZNF608 lung,NS,carcinoma,small cell carcinoma c.3511C>T p.P1171S 5:124646873-124646873 15
27 COSM316859 ZNF608 lung,NS,carcinoma,small cell carcinoma c.1722G>T p.Q574H 5:124648662-124648662 15
28 COSM316850 ZNF574 lung,NS,carcinoma,small cell carcinoma c.590C>G p.S197C 19:42079196-42079196 15
29 COSM316847 ZNF566 lung,NS,carcinoma,small cell carcinoma c.174G>T p.L58F 19:36472969-36472969 15
30 COSM316840 ZNF536 lung,NS,carcinoma,small cell carcinoma c.3241C>A p.Q1081K 19:30548860-30548860 15
31 COSM318333 ZNF536 lung,NS,carcinoma,small cell carcinoma c.2185G>A p.A729T 19:30534861-30534861 15
32 COSM318328 ZNF536 lung,NS,carcinoma,small cell carcinoma c.3646C>A p.Q1216K 19:30549265-30549265 15
33 COSM316839 ZNF536 lung,NS,carcinoma,small cell carcinoma c.383G>T p.R128L 19:30443945-30443945 15
34 COSM318334 ZNF536 lung,NS,carcinoma,small cell carcinoma c.1216C>A p.P406T 19:30444778-30444778 15
35 COSM318330 ZNF536 lung,NS,carcinoma,small cell carcinoma c.2259C>A p.C753* 19:30534935-30534935 15
36 COSM318325 ZNF521 lung,NS,carcinoma,small cell carcinoma c.3640G>T p.V1214F 18:25195178-25195178 15
37 COSM318326 ZNF521 lung,NS,carcinoma,small cell carcinoma c.2227G>T p.V743L 18:25225691-25225691 15
38 COSM316833 ZNF521 lung,NS,carcinoma,small cell carcinoma c.559G>C p.D187H 18:25227359-25227359 15
39 COSM318321 ZNF521 lung,NS,carcinoma,small cell carcinoma c.2620G>T p.G874W 18:25225298-25225298 15
40 COSM318320 ZNF521 lung,NS,carcinoma,small cell carcinoma c.3289G>A p.V1097M 18:25224629-25224629 15
41 COSM316830 ZNF512 lung,NS,carcinoma,small cell carcinoma c.698A>G p.D233G 2:27602491-27602491 15
42 COSM316826 ZNF507 lung,NS,carcinoma,small cell carcinoma c.1899C>G p.Y633* 19:32354729-32354729 15
43 COSM316827 ZNF507 lung,NS,carcinoma,small cell carcinoma c.1007C>G p.S336C 19:32353837-32353837 15
44 COSM316819 ZNF479 lung,NS,carcinoma,small cell carcinoma c.1027C>T p.H343Y 7:57120388-57120388 15
45 COSM316813 ZNF462 lung,NS,carcinoma,small cell carcinoma c.5136G>T p.L1712L 9:106929048-106929048 15
46 COSM316807 ZNF444 lung,NS,carcinoma,small cell carcinoma c.239T>A p.V80E 19:56147150-56147150 15
47 COSM316793 ZNF423 lung,NS,carcinoma,small cell carcinoma c.146C>A p.T49K 16:49730902-49730902 15
48 COSM316795 ZNF423 lung,NS,carcinoma,small cell carcinoma c.3329C>A p.P1110H 16:49635823-49635823 15
49 COSM316797 ZNF423 lung,NS,carcinoma,small cell carcinoma c.1772T>G p.I591S 16:49637380-49637380 15
50 COSM316776 ZNF385B lung,NS,carcinoma,small cell carcinoma c.1381G>T p.A461S 2:179443285-179443285 15

Expression for Lung Combined Type Small Cell Carcinoma

Search GEO for disease gene expression data for Lung Combined Type Small Cell Carcinoma.

Pathways for Lung Combined Type Small Cell Carcinoma

Pathways related to Lung Combined Type Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 GFAP NCAM1 SYP
2 11.02 MME NCAM1
3 10.7 GFAP NCAM1 SYP

GO Terms for Lung Combined Type Small Cell Carcinoma

Cellular components related to Lung Combined Type Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection terminus GO:0044306 8.62 MME SYP

Sources for Lung Combined Type Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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