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MCID: LNG019
MIFTS: 24

Lung Combined Type Small Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Lung Combined Type Small Cell Carcinoma

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MalaCards integrated aliases for Lung Combined Type Small Cell Carcinoma:

Name: Lung Combined Type Small Cell Carcinoma 12 15
Combined Type Small Cell Carcinoma of Lung 12
Combined Small Cell Carcinoma of the Lung 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5421
NCIt 51 C9137
UMLS 74 C1333125
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Summaries for Lung Combined Type Small Cell Carcinoma

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Disease Ontology : 12 A lung small cell carcinoma that is characterized as a multiphasic lung cancer comprised of a mixture of small cell and non-small cell lung carcinoma cells.

MalaCards based summary : Lung Combined Type Small Cell Carcinoma, also known as combined type small cell carcinoma of lung, is related to small cell carcinoma and lung combined type small cell adenocarcinoma. An important gene associated with Lung Combined Type Small Cell Carcinoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include lung and skeletal muscle.

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Related Diseases for Lung Combined Type Small Cell Carcinoma

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Diseases related to Lung Combined Type Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.6 NCAM1 SYP
2 lung combined type small cell adenocarcinoma 11.3
3 ependymoma 10.3 GFAP SYP
4 desmoplastic infantile ganglioglioma 10.3 GFAP SYP
5 ganglioglioma 10.3 GFAP SYP
6 extraventricular neurocytoma 10.3 GFAP SYP
7 cellular ependymoma 10.2 GFAP SYP
8 chordoid meningioma 10.2 GFAP SYP
9 central nervous system primitive neuroectodermal neoplasm 10.2 GFAP SYP
10 clear cell ependymoma 10.2 GFAP SYP
11 chiari malformation 10.2 GFAP SYP
12 dysembryoplastic neuroepithelial tumor 10.2 GFAP SYP
13 cerebral neuroblastoma 10.2 GFAP SYP
14 subependymal glioma 10.2 GFAP SYP
15 papillary ependymoma 10.2 GFAP SYP
16 astroblastoma 10.2 GFAP SYP
17 cerebral ventricle cancer 10.2 GFAP SYP
18 pineal gland cancer 10.2 GFAP SYP
19 melanotic neuroectodermal tumor 10.2 GFAP SYP
20 benign ependymoma 10.2 GFAP SYP
21 angiocentric glioma 10.2 GFAP SYP
22 obstructive hydrocephalus 10.2 GFAP SYP
23 medulloepithelioma 10.2 GFAP SYP
24 pineocytoma 10.2 GFAP SYP
25 anaplastic ependymoma 10.2 GFAP SYP
26 childhood oligodendroglioma 10.2 GFAP SYP
27 oligodendroglioma 10.2 GFAP SYP
28 pleomorphic xanthoastrocytoma 10.2 GFAP SYP
29 tanycytic ependymoma 10.2 GFAP SYP
30 pineoblastoma 10.2 GFAP SYP
31 papilloma of choroid plexus 10.2 GFAP SYP
32 central neurocytoma 10.2 GFAP SYP
33 binswanger's disease 10.2 GFAP SYP
34 cystic teratoma 10.2 GFAP SYP
35 teratoma 10.2 GFAP SYP
36 subependymal giant cell astrocytoma 10.2 GFAP SYP
37 central nervous system benign neoplasm 10.2 GFAP SYP
38 cerebellar liponeurocytoma 10.2 GFAP SYP
39 pilomyxoid astrocytoma 10.2 GFAP SYP
40 cystadenoma 10.2 MME SYP
41 cerebellopontine angle tumor 10.2 GFAP SYP
42 adult medulloblastoma 10.2 GFAP SYP
43 perivascular epithelioid cell tumor 10.2 MME SYP
44 optic nerve glioma 10.1 GFAP SYP
45 fallopian tube endometrioid adenocarcinoma 10.1 MME MYOG
46 infratentorial cancer 10.1 GFAP SYP
47 myxopapillary ependymoma 10.1 GFAP NCAM1
48 fallopian tube adenocarcinoma 10.1 MME MYOG
49 giant cell glioblastoma 10.1 GFAP SYP
50 esophageal neuroendocrine tumor 10.1 NCAM1 SYP

Graphical network of the top 20 diseases related to Lung Combined Type Small Cell Carcinoma:



Diseases related to Lung Combined Type Small Cell Carcinoma
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Symptoms & Phenotypes for Lung Combined Type Small Cell Carcinoma

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Drugs & Therapeutics for Lung Combined Type Small Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Lung Combined Type Small Cell Carcinoma

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Genetic Tests for Lung Combined Type Small Cell Carcinoma

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Anatomical Context for Lung Combined Type Small Cell Carcinoma

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MalaCards organs/tissues related to Lung Combined Type Small Cell Carcinoma:

42
Lung, Skeletal Muscle
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Publications for Lung Combined Type Small Cell Carcinoma

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Articles related to Lung Combined Type Small Cell Carcinoma:

# Title Authors Year
1
Combined Small Cell Carcinoma of the Lung: Is It a Single Entity? ( 29101056 )
2018
2
Combined small cell carcinoma of the lung: a case diagnosed on bronchoscopic wash cytology and bronchial biopsy. ( 24734994 )
2015
3
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type. ( 21210145 )
2011
4
A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma, revisited. ( 15784404 )
2005
5
A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma. ( 15519208 )
2004
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Variations for Lung Combined Type Small Cell Carcinoma

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Cosmic variations for Lung Combined Type Small Cell Carcinoma:

9 (show top 50) (show all 5597)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM316964 ZZEF1 lung,NS,carcinoma,small cell carcinoma c.4892G>T p.G1631V 17:4059282-4059282 0
2 COSM316963 ZYG11B lung,NS,carcinoma,small cell carcinoma c.1635G>C p.M545I 1:52801968-52801968 0
3 COSM316957 ZSWIM4 lung,NS,carcinoma,small cell carcinoma c.944G>T p.R315L 19:13809152-13809152 0
4 COSM6982093 ZRSR2 lung,NS,carcinoma,small cell carcinoma c.1180G>A p.E394K 23:15822973-15822973 0
5 COSM316946 ZRANB2 lung,NS,carcinoma,small cell carcinoma c.17T>C p.F6S 1:71080979-71080979 0
6 COSM316944 ZP2 lung,NS,carcinoma,small cell carcinoma c.1608C>T p.P536P 16:21201455-21201455 0
7 COSM316937 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1024A>G p.T342A 12:133057739-133057739 0
8 COSM316935 ZNF831 lung,NS,carcinoma,small cell carcinoma c.1027G>C p.D343H 20:59192046-59192046 0
9 COSM316926 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3753G>C p.L1251L 7:89336735-89336735 0
10 COSM316923 ZNF804B lung,NS,carcinoma,small cell carcinoma c.522C>A p.P174P 7:89333504-89333504 0
11 COSM318343 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3661G>C p.A1221P 7:89336643-89336643 0
12 COSM316920 ZNF804A lung,NS,carcinoma,small cell carcinoma c.3281C>T p.S1094F 2:184938677-184938677 0
13 COSM318342 ZNF804A lung,NS,carcinoma,small cell carcinoma c.862A>T p.K288* 2:184936258-184936258 0
14 COSM316909 ZNF777 lung,NS,carcinoma,small cell carcinoma c.1998C>T p.C666C 7:149432274-149432274 0
15 COSM316903 ZNF746 lung,NS,carcinoma,small cell carcinoma c.887C>T p.A296V 7:149475432-149475432 0
16 COSM318340 ZNF711 lung,NS,carcinoma,small cell carcinoma c.113A>T p.D38V 23:85255352-85255352 0
17 COSM316902 ZNF711 lung,NS,carcinoma,small cell carcinoma c.1401G>T p.E467D 23:85270913-85270913 0
18 COSM318339 ZNF7 lung,NS,carcinoma,small cell carcinoma c.989G>C p.G330A 8:144842096-144842096 0
19 COSM316887 ZNF667 lung,NS,carcinoma,small cell carcinoma c.132G>T p.L44F 19:56460717-56460717 0
20 COSM316886 ZNF660 lung,NS,carcinoma,small cell carcinoma c.575G>A p.C192Y 3:44594768-44594768 0
21 COSM316882 ZNF653 lung,NS,carcinoma,small cell carcinoma c.808C>T p.P270S 19:11487655-11487655 0
22 COSM316883 ZNF653 lung,NS,carcinoma,small cell carcinoma c.346C>T p.R116W 19:11496163-11496163 0
23 COSM316871 ZNF638 lung,NS,carcinoma,small cell carcinoma c.1926G>A p.K642K 2:71365637-71365637 0
24 COSM316869 ZNF630 lung,NS,carcinoma,small cell carcinoma c.1534G>C p.E512Q 23:48058908-48058908 0
25 COSM316861 ZNF609 lung,NS,carcinoma,small cell carcinoma c.1497C>T p.H499H 15:64674351-64674351 0
26 COSM316860 ZNF608 lung,NS,carcinoma,small cell carcinoma c.3511C>T p.P1171S 5:124646873-124646873 0
27 COSM316859 ZNF608 lung,NS,carcinoma,small cell carcinoma c.1722G>T p.Q574H 5:124648662-124648662 0
28 COSM316850 ZNF574 lung,NS,carcinoma,small cell carcinoma c.590C>G p.S197C 19:42079196-42079196 0
29 COSM316847 ZNF566 lung,NS,carcinoma,small cell carcinoma c.174G>T p.L58F 19:36472969-36472969 0
30 COSM316840 ZNF536 lung,NS,carcinoma,small cell carcinoma c.3241C>A p.Q1081K 19:30548860-30548860 0
31 COSM318333 ZNF536 lung,NS,carcinoma,small cell carcinoma c.2185G>A p.A729T 19:30534861-30534861 0
32 COSM318328 ZNF536 lung,NS,carcinoma,small cell carcinoma c.3646C>A p.Q1216K 19:30549265-30549265 0
33 COSM316839 ZNF536 lung,NS,carcinoma,small cell carcinoma c.383G>T p.R128L 19:30443945-30443945 0
34 COSM318334 ZNF536 lung,NS,carcinoma,small cell carcinoma c.1216C>A p.P406T 19:30444778-30444778 0
35 COSM318330 ZNF536 lung,NS,carcinoma,small cell carcinoma c.2259C>A p.C753* 19:30534935-30534935 0
36 COSM318325 ZNF521 lung,NS,carcinoma,small cell carcinoma c.3640G>T p.V1214F 18:25195178-25195178 0
37 COSM318326 ZNF521 lung,NS,carcinoma,small cell carcinoma c.2227G>T p.V743L 18:25225691-25225691 0
38 COSM316833 ZNF521 lung,NS,carcinoma,small cell carcinoma c.559G>C p.D187H 18:25227359-25227359 0
39 COSM318321 ZNF521 lung,NS,carcinoma,small cell carcinoma c.2620G>T p.G874W 18:25225298-25225298 0
40 COSM318320 ZNF521 lung,NS,carcinoma,small cell carcinoma c.3289G>A p.V1097M 18:25224629-25224629 0
41 COSM316830 ZNF512 lung,NS,carcinoma,small cell carcinoma c.698A>G p.D233G 2:27602491-27602491 0
42 COSM316826 ZNF507 lung,NS,carcinoma,small cell carcinoma c.1899C>G p.Y633* 19:32354729-32354729 0
43 COSM316827 ZNF507 lung,NS,carcinoma,small cell carcinoma c.1007C>G p.S336C 19:32353837-32353837 0
44 COSM316819 ZNF479 lung,NS,carcinoma,small cell carcinoma c.1027C>T p.H343Y 7:57120388-57120388 0
45 COSM316813 ZNF462 lung,NS,carcinoma,small cell carcinoma c.5136G>T p.L1712L 9:106929048-106929048 0
46 COSM316807 ZNF444 lung,NS,carcinoma,small cell carcinoma c.239T>A p.V80E 19:56147150-56147150 0
47 COSM316793 ZNF423 lung,NS,carcinoma,small cell carcinoma c.146C>A p.T49K 16:49730902-49730902 0
48 COSM316795 ZNF423 lung,NS,carcinoma,small cell carcinoma c.3329C>A p.P1110H 16:49635823-49635823 0
49 COSM316797 ZNF423 lung,NS,carcinoma,small cell carcinoma c.1772T>G p.I591S 16:49637380-49637380 0
50 COSM316776 ZNF385B lung,NS,carcinoma,small cell carcinoma c.1381G>T p.A461S 2:179443285-179443285 0
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Expression for Lung Combined Type Small Cell Carcinoma

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Search GEO for disease gene expression data for Lung Combined Type Small Cell Carcinoma.
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Pathways for Lung Combined Type Small Cell Carcinoma

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Pathways related to Lung Combined Type Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.67 GFAP NCAM1 SYP
2
Dendritic Cells Developmental Lineage Pathway 66
11.02 MME NCAM1
3
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
10.7 GFAP NCAM1 SYP
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GO Terms for Lung Combined Type Small Cell Carcinoma

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Cellular components related to Lung Combined Type Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection terminus GO:0044306 8.62 MME SYP
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Sources for Lung Combined Type Small Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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