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MCID: LNG019
MIFTS: 27

Lung Combined Type Small Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Lung Combined Type Small Cell Carcinoma

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MalaCards integrated aliases for Lung Combined Type Small Cell Carcinoma:

Name: Lung Combined Type Small Cell Carcinoma 11 14
Combined Type Small Cell Carcinoma of Lung 11
Combined Small Cell Carcinoma of the Lung 11

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:5421
NCIt 49 C9137
UMLS 71 C1333125
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Summaries for Lung Combined Type Small Cell Carcinoma

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Disease Ontology: 11 A lung small cell carcinoma that is characterized as a multiphasic lung cancer comprised of a mixture of small cell and non-small cell lung carcinoma cells.

MalaCards based summary: Lung Combined Type Small Cell Carcinoma, also known as combined type small cell carcinoma of lung, is related to lung combined type small cell adenocarcinoma and small cell carcinoma. An important gene associated with Lung Combined Type Small Cell Carcinoma is TKFC (Triokinase And FMN Cyclase), and among its related pathways/superpathways is Development Notch Signaling Pathway. Affiliated tissues include lung and skeletal muscle.
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Related Diseases for Lung Combined Type Small Cell Carcinoma

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Diseases related to Lung Combined Type Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 lung combined type small cell adenocarcinoma 11.4
2 small cell carcinoma 10.5
3 small cell cancer of the lung 10.3
4 lung cancer 10.1
5 bronchus cancer 10.1
6 spindle cell sarcoma 10.1
7 pilocytic astrocytoma 9.7 TP73 H3-3B
8 connective tissue benign neoplasm 9.6 H3-3B CALD1
9 anaplastic astrocytoma 9.6 TP73 H3-3B

Graphical network of the top 20 diseases related to Lung Combined Type Small Cell Carcinoma:



Diseases related to Lung Combined Type Small Cell Carcinoma
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Symptoms & Phenotypes for Lung Combined Type Small Cell Carcinoma

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Drugs & Therapeutics for Lung Combined Type Small Cell Carcinoma

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Search Clinical Trials, NIH Clinical Center for Lung Combined Type Small Cell Carcinoma

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Genetic Tests for Lung Combined Type Small Cell Carcinoma

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Anatomical Context for Lung Combined Type Small Cell Carcinoma

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Organs/tissues related to Lung Combined Type Small Cell Carcinoma:

MalaCards : Lung, Skeletal Muscle
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Publications for Lung Combined Type Small Cell Carcinoma

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Articles related to Lung Combined Type Small Cell Carcinoma:

# Title Authors PMID Year
1
Combined Small Cell Carcinoma of the Lung: Is It a Single Entity? 62
29101056 2018
2
Combined small cell carcinoma of the lung: a case diagnosed on bronchoscopic wash cytology and bronchial biopsy. 62
24734994 2015
3
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type. 62
21210145 2011
4
A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma, revisited. 62
15784404 2005
5
A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma. 62
15519208 2004
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Variations for Lung Combined Type Small Cell Carcinoma

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Cosmic variations for Lung Combined Type Small Cell Carcinoma:

8 (show top 50) (show all 15093)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM98616023 ZZEF1 lung,NS,carcinoma,small cell carcinoma c.4892G>T p.G1631V 17:4059282-4059282 12
2 COSM132740059 ZYG11B lung,NS,carcinoma,small cell carcinoma c.1635G>C p.M545I 1:52801968-52801968 12
3 COSM86240454 ZYG11B lung,NS,carcinoma,small cell carcinoma c.1635G>C p.M545I 1:52801968-52801968 12
4 COSM86919234 ZSWIM4 lung,NS,carcinoma,small cell carcinoma c.944G>T p.R315L 19:13809152-13809152 12
5 COSM88262283 ZRSR2 lung,NS,carcinoma,small cell carcinoma c.1180G>A p.E394K 23:15822973-15822973 12
6 COSM143073175 ZRANB2 lung,NS,carcinoma,small cell carcinoma c.17T>C p.F6S 1:71080979-71080979 12
7 COSM97720347 ZRANB2 lung,NS,carcinoma,small cell carcinoma c.17T>C p.F6S 1:71080979-71080979 12
8 COSM87171618 ZRANB2 lung,NS,carcinoma,small cell carcinoma c.17T>C p.F6S 1:71080979-71080979 12
9 COSM137271685 ZP2 lung,NS,carcinoma,small cell carcinoma c.1581C>T p.P527= 16:21201455-21201455 12
10 COSM137165710 ZP2 lung,NS,carcinoma,small cell carcinoma c.1608C>T p.P536= 16:21201455-21201455 12
11 COSM131896932 ZNF84 lung,NS,carcinoma,small cell carcinoma c.239-5340A>G p.? 12:133057739-133057739 12
12 COSM101262318 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1024A>G p.T342A 12:133057739-133057739 12
13 COSM91416826 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1024A>G p.T342A 12:133057739-133057739 12
14 COSM133556674 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1021A>G p.T341A 12:133057739-133057739 12
15 COSM130336034 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1024A>G p.T342A 12:133057739-133057739 12
16 COSM98062407 ZNF831 lung,NS,carcinoma,small cell carcinoma c.1027G>C p.D343H 20:59192046-59192046 12
17 COSM149927805 ZNF831 lung,NS,carcinoma,small cell carcinoma c.1027G>C p.D343H 20:59192046-59192046 12
18 COSM92021621 ZNF804B lung,NS,carcinoma,small cell carcinoma c.522C>A p.P174= 7:89333504-89333504 12
19 COSM142170486 ZNF804B lung,NS,carcinoma,small cell carcinoma c.273C>A p.P91= 7:89333504-89333504 12
20 COSM142179504 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3504G>C p.L1168= 7:89336735-89336735 12
21 COSM142171430 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3412G>C p.A1138P 7:89336643-89336643 12
22 COSM92048538 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3753G>C p.L1251= 7:89336735-89336735 12
23 COSM92024942 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3661G>C p.A1221P 7:89336643-89336643 12
24 COSM88575001 ZNF804A lung,NS,carcinoma,small cell carcinoma c.862A>T p.K288* 2:184936258-184936258 12
25 COSM88576053 ZNF804A lung,NS,carcinoma,small cell carcinoma c.3281C>T p.S1094F 2:184938677-184938677 12
26 COSM143615605 ZNF804A lung,NS,carcinoma,small cell carcinoma c.607A>T p.K203* 2:184936258-184936258 12
27 COSM143615950 ZNF804A lung,NS,carcinoma,small cell carcinoma c.3026C>T p.S1009F 2:184938677-184938677 12
28 COSM84362584 ZNF777 lung,NS,carcinoma,small cell carcinoma c.1998C>T p.C666= 7:149432274-149432274 12
29 COSM91557035 ZNF746 lung,NS,carcinoma,small cell carcinoma c.887C>T p.A296V 7:149475432-149475432 12
30 COSM151200494 ZNF746 lung,NS,carcinoma,small cell carcinoma c.932C>T p.A311V 7:149475432-149475432 12
31 COSM114445791 ZNF746 lung,NS,carcinoma,small cell carcinoma c.890C>T p.A297V 7:149475432-149475432 12
32 COSM97007058 ZNF711 lung,NS,carcinoma,small cell carcinoma c.173A>T p.D58V 23:85255352-85255352 12
33 COSM87004058 ZNF711 lung,NS,carcinoma,small cell carcinoma c.1371G>T p.E457D 23:85270913-85270913 12
34 COSM96524071 ZNF711 lung,NS,carcinoma,small cell carcinoma c.1371G>T p.E457D 23:85270913-85270913 12
35 COSM87004493 ZNF711 lung,NS,carcinoma,small cell carcinoma c.173A>T p.D58V 23:85255352-85255352 12
36 COSM97006621 ZNF711 lung,NS,carcinoma,small cell carcinoma c.1509G>T p.E503D 23:85270913-85270913 12
37 COSM96524396 ZNF711 lung,NS,carcinoma,small cell carcinoma c.173A>T p.D58V 23:85255352-85255352 12
38 COSM130605261 ZNF7 lung,NS,carcinoma,small cell carcinoma c.701G>C p.G234A 8:144842096-144842096 12
39 COSM89464457 ZNF7 lung,NS,carcinoma,small cell carcinoma c.281-3883G>C p.? 8:144842096-144842096 12
40 COSM129405109 ZNF7 lung,NS,carcinoma,small cell carcinoma c.248-3883G>C p.? 8:144842096-144842096 12
41 COSM110827987 ZNF7 lung,NS,carcinoma,small cell carcinoma c.1022G>C p.G341A 8:144842096-144842096 12
42 COSM130688921 ZNF7 lung,NS,carcinoma,small cell carcinoma c.989G>C p.G330A 8:144842096-144842096 12
43 COSM141336221 ZNF667 lung,NS,carcinoma,small cell carcinoma c.132G>T p.L44F 19:56460717-56460717 12
44 COSM122146768 ZNF667 lung,NS,carcinoma,small cell carcinoma c.132G>T p.L44F 19:56460717-56460717 12
45 COSM85394970 ZNF667 lung,NS,carcinoma,small cell carcinoma c.132G>T p.L44F 19:56460717-56460717 12
46 COSM92174992 ZNF660 lung,NS,carcinoma,small cell carcinoma c.575G>A p.C192Y 3:44594768-44594768 12
47 COSM86006104 ZNF653 lung,NS,carcinoma,small cell carcinoma c.808C>T p.P270S 19:11487655-11487655 12
48 COSM86006115 ZNF653 lung,NS,carcinoma,small cell carcinoma c.346C>T p.R116W 19:11496163-11496163 12
49 COSM105713312 ZNF638 lung,NS,carcinoma,small cell carcinoma c.1926G>A p.K642= 2:71365637-71365637 12
50 COSM105035820 ZNF638 lung,NS,carcinoma,small cell carcinoma c.1926G>A p.K642= 2:71365637-71365637 12
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Expression for Lung Combined Type Small Cell Carcinoma

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Search GEO for disease gene expression data for Lung Combined Type Small Cell Carcinoma.
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Pathways for Lung Combined Type Small Cell Carcinoma

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Pathways related to Lung Combined Type Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development Notch Signaling Pathway 22
Show member pathways
 10.7 TP73 H3-3B
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GO Terms for Lung Combined Type Small Cell Carcinoma

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Sources for Lung Combined Type Small Cell Carcinoma

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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