MCID: LNG019
MIFTS: 34

Lung Combined Type Small Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Combined Type Small Cell Carcinoma

MalaCards integrated aliases for Lung Combined Type Small Cell Carcinoma:

Name: Lung Combined Type Small Cell Carcinoma 12 15
Combined Type Small Cell Carcinoma of Lung 12
Combined Small Cell Carcinoma of the Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5421
NCIt 50 C9137
UMLS 70 C1333125

Summaries for Lung Combined Type Small Cell Carcinoma

Disease Ontology : 12 A lung small cell carcinoma that is characterized as a multiphasic lung cancer comprised of a mixture of small cell and non-small cell lung carcinoma cells.

MalaCards based summary : Lung Combined Type Small Cell Carcinoma, also known as combined type small cell carcinoma of lung, is related to small cell carcinoma and spindle cell sarcoma. An important gene associated with Lung Combined Type Small Cell Carcinoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Neuroscience and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include lung, breast and prostate.

Related Diseases for Lung Combined Type Small Cell Carcinoma

Diseases related to Lung Combined Type Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.8 SYP NCAM1
2 spindle cell sarcoma 30.3 MYOG CALD1
3 lung combined type small cell adenocarcinoma 11.3
4 squamous cell carcinoma 10.3
5 conventional leiomyosarcoma 10.2 MYOG CALD1
6 prostate embryonal rhabdomyosarcoma 10.2 MYOG CALD1
7 inflammatory leiomyosarcoma 10.2 MYOG CALD1
8 adult fibrosarcoma 10.2 MYOG CALD1
9 retroperitoneal sarcoma 10.2 MYOG CALD1
10 malignant mesenchymoma 10.2 MYOG CALD1
11 uterus leiomyosarcoma 10.2 MYOG CALD1
12 uterine corpus sarcoma 10.2 MYOG CALD1
13 deep leiomyoma 10.2 GFAP CALD1
14 cutaneous leiomyosarcoma 10.1 GFAP CALD1
15 bladder sarcoma 10.1 MYOG CALD1
16 pseudosarcomatous fibromatosis 10.1 MYOG CALD1
17 glomangioma 10.1 SYP CALD1
18 glomangiomyoma 10.1 SYP CALD1
19 benign perivascular tumor 10.1 SYP CALD1
20 breast rhabdomyosarcoma 10.1 NCAM1 MYOG
21 myoblastoma 10.1 SYP MYOG
22 subungual glomus tumor 10.1 SYP CALD1
23 glomus tumor 10.1 SYP CALD1
24 spindle cell rhabdomyosarcoma 10.1 MYOG GFAP
25 well-differentiated liposarcoma 10.1 MYOG CALD1
26 myocardium cancer 10.1 SYP MYOG
27 endobronchial lipoma 10.1 SYP CALD1
28 pineal region teratoma 10.1 SYP MYOG
29 retroperitoneum carcinoma 10.1 SYP CALD1
30 hypertryptophanemia 10.1 NCAM1 GFAP
31 papillary ependymoma 10.1 SYP GFAP
32 extraventricular neurocytoma 10.1 SYP GFAP
33 askin's tumor 10.1 SYP MYOG
34 desmoplastic infantile ganglioglioma 10.0 SYP GFAP
35 ganglioglioma 10.0 SYP GFAP
36 anal neuroendocrine tumor 10.0 SYP NCAM1
37 cerebral neuroblastoma 10.0 SYP GFAP
38 esophageal neuroendocrine tumor 10.0 SYP NCAM1
39 myxofibrosarcoma 10.0 MYOG CALD1
40 hypoganglionosis 10.0 SYP NCAM1
41 laryngeal small cell carcinoma 10.0 SYP NCAM1
42 gallbladder small cell carcinoma 10.0 SYP NCAM1
43 ureter small cell carcinoma 10.0 SYP NCAM1
44 papillary thymic adenocarcinoma 10.0 SYP NCAM1
45 urinary bladder small cell neuroendocrine carcinoma 10.0 SYP NCAM1
46 neuroendocrine carcinoma 10.0 SYP NCAM1
47 perineurioma 10.0 NCAM1 GFAP
48 gastric small cell carcinoma 10.0 SYP NCAM1
49 sensory organ benign neoplasm 10.0 SYP NCAM1
50 laryngeal neuroendocrine tumor 10.0 SYP NCAM1

Graphical network of the top 20 diseases related to Lung Combined Type Small Cell Carcinoma:



Diseases related to Lung Combined Type Small Cell Carcinoma

Symptoms & Phenotypes for Lung Combined Type Small Cell Carcinoma

Drugs & Therapeutics for Lung Combined Type Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Combined Type Small Cell Carcinoma

Genetic Tests for Lung Combined Type Small Cell Carcinoma

Anatomical Context for Lung Combined Type Small Cell Carcinoma

MalaCards organs/tissues related to Lung Combined Type Small Cell Carcinoma:

40
Lung, Breast, Prostate, Skeletal Muscle, Spinal Cord, Smooth Muscle, Uterus

Publications for Lung Combined Type Small Cell Carcinoma

Articles related to Lung Combined Type Small Cell Carcinoma:

# Title Authors PMID Year
1
Combined Small Cell Carcinoma of the Lung: Is It a Single Entity? 61
29101056 2018
2
Combined small cell carcinoma of the lung: a case diagnosed on bronchoscopic wash cytology and bronchial biopsy. 61
24734994 2015
3
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type. 61
21210145 2011
4
A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma, revisited. 61
15784404 2005
5
A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma. 61
15519208 2004

Variations for Lung Combined Type Small Cell Carcinoma

Cosmic variations for Lung Combined Type Small Cell Carcinoma:

9 (show top 50) (show all 15093)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM98616023 ZZEF1 lung,NS,carcinoma,small cell carcinoma c.4892G>T p.G1631V 17:4059282-4059282 12
2 COSM132740059 ZYG11B lung,NS,carcinoma,small cell carcinoma c.1635G>C p.M545I 1:52801968-52801968 12
3 COSM86240454 ZYG11B lung,NS,carcinoma,small cell carcinoma c.1635G>C p.M545I 1:52801968-52801968 12
4 COSM86919234 ZSWIM4 lung,NS,carcinoma,small cell carcinoma c.944G>T p.R315L 19:13809152-13809152 12
5 COSM88262283 ZRSR2 lung,NS,carcinoma,small cell carcinoma c.1180G>A p.E394K 23:15822973-15822973 12
6 COSM143073175 ZRANB2 lung,NS,carcinoma,small cell carcinoma c.17T>C p.F6S 1:71080979-71080979 12
7 COSM97720347 ZRANB2 lung,NS,carcinoma,small cell carcinoma c.17T>C p.F6S 1:71080979-71080979 12
8 COSM87171618 ZRANB2 lung,NS,carcinoma,small cell carcinoma c.17T>C p.F6S 1:71080979-71080979 12
9 COSM137271685 ZP2 lung,NS,carcinoma,small cell carcinoma c.1581C>T p.P527= 16:21201455-21201455 12
10 COSM137165710 ZP2 lung,NS,carcinoma,small cell carcinoma c.1608C>T p.P536= 16:21201455-21201455 12
11 COSM131896932 ZNF84 lung,NS,carcinoma,small cell carcinoma c.239-5340A>G p.? 12:133057739-133057739 12
12 COSM101262318 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1024A>G p.T342A 12:133057739-133057739 12
13 COSM91416826 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1024A>G p.T342A 12:133057739-133057739 12
14 COSM133556674 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1021A>G p.T341A 12:133057739-133057739 12
15 COSM130336034 ZNF84 lung,NS,carcinoma,small cell carcinoma c.1024A>G p.T342A 12:133057739-133057739 12
16 COSM98062407 ZNF831 lung,NS,carcinoma,small cell carcinoma c.1027G>C p.D343H 20:59192046-59192046 12
17 COSM149927805 ZNF831 lung,NS,carcinoma,small cell carcinoma c.1027G>C p.D343H 20:59192046-59192046 12
18 COSM92021621 ZNF804B lung,NS,carcinoma,small cell carcinoma c.522C>A p.P174= 7:89333504-89333504 12
19 COSM142170486 ZNF804B lung,NS,carcinoma,small cell carcinoma c.273C>A p.P91= 7:89333504-89333504 12
20 COSM142179504 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3504G>C p.L1168= 7:89336735-89336735 12
21 COSM142171430 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3412G>C p.A1138P 7:89336643-89336643 12
22 COSM92048538 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3753G>C p.L1251= 7:89336735-89336735 12
23 COSM92024942 ZNF804B lung,NS,carcinoma,small cell carcinoma c.3661G>C p.A1221P 7:89336643-89336643 12
24 COSM88575001 ZNF804A lung,NS,carcinoma,small cell carcinoma c.862A>T p.K288* 2:184936258-184936258 12
25 COSM88576053 ZNF804A lung,NS,carcinoma,small cell carcinoma c.3281C>T p.S1094F 2:184938677-184938677 12
26 COSM143615605 ZNF804A lung,NS,carcinoma,small cell carcinoma c.607A>T p.K203* 2:184936258-184936258 12
27 COSM143615950 ZNF804A lung,NS,carcinoma,small cell carcinoma c.3026C>T p.S1009F 2:184938677-184938677 12
28 COSM84362584 ZNF777 lung,NS,carcinoma,small cell carcinoma c.1998C>T p.C666= 7:149432274-149432274 12
29 COSM91557035 ZNF746 lung,NS,carcinoma,small cell carcinoma c.887C>T p.A296V 7:149475432-149475432 12
30 COSM151200494 ZNF746 lung,NS,carcinoma,small cell carcinoma c.932C>T p.A311V 7:149475432-149475432 12
31 COSM114445791 ZNF746 lung,NS,carcinoma,small cell carcinoma c.890C>T p.A297V 7:149475432-149475432 12
32 COSM97007058 ZNF711 lung,NS,carcinoma,small cell carcinoma c.173A>T p.D58V 23:85255352-85255352 12
33 COSM87004058 ZNF711 lung,NS,carcinoma,small cell carcinoma c.1371G>T p.E457D 23:85270913-85270913 12
34 COSM96524071 ZNF711 lung,NS,carcinoma,small cell carcinoma c.1371G>T p.E457D 23:85270913-85270913 12
35 COSM87004493 ZNF711 lung,NS,carcinoma,small cell carcinoma c.173A>T p.D58V 23:85255352-85255352 12
36 COSM97006621 ZNF711 lung,NS,carcinoma,small cell carcinoma c.1509G>T p.E503D 23:85270913-85270913 12
37 COSM96524396 ZNF711 lung,NS,carcinoma,small cell carcinoma c.173A>T p.D58V 23:85255352-85255352 12
38 COSM130605261 ZNF7 lung,NS,carcinoma,small cell carcinoma c.701G>C p.G234A 8:144842096-144842096 12
39 COSM89464457 ZNF7 lung,NS,carcinoma,small cell carcinoma c.281-3883G>C p.? 8:144842096-144842096 12
40 COSM129405109 ZNF7 lung,NS,carcinoma,small cell carcinoma c.248-3883G>C p.? 8:144842096-144842096 12
41 COSM110827987 ZNF7 lung,NS,carcinoma,small cell carcinoma c.1022G>C p.G341A 8:144842096-144842096 12
42 COSM130688921 ZNF7 lung,NS,carcinoma,small cell carcinoma c.989G>C p.G330A 8:144842096-144842096 12
43 COSM141336221 ZNF667 lung,NS,carcinoma,small cell carcinoma c.132G>T p.L44F 19:56460717-56460717 12
44 COSM122146768 ZNF667 lung,NS,carcinoma,small cell carcinoma c.132G>T p.L44F 19:56460717-56460717 12
45 COSM85394970 ZNF667 lung,NS,carcinoma,small cell carcinoma c.132G>T p.L44F 19:56460717-56460717 12
46 COSM92174992 ZNF660 lung,NS,carcinoma,small cell carcinoma c.575G>A p.C192Y 3:44594768-44594768 12
47 COSM86006104 ZNF653 lung,NS,carcinoma,small cell carcinoma c.808C>T p.P270S 19:11487655-11487655 12
48 COSM86006115 ZNF653 lung,NS,carcinoma,small cell carcinoma c.346C>T p.R116W 19:11496163-11496163 12
49 COSM105713312 ZNF638 lung,NS,carcinoma,small cell carcinoma c.1926G>A p.K642= 2:71365637-71365637 12
50 COSM105035820 ZNF638 lung,NS,carcinoma,small cell carcinoma c.1926G>A p.K642= 2:71365637-71365637 12

Expression for Lung Combined Type Small Cell Carcinoma

Search GEO for disease gene expression data for Lung Combined Type Small Cell Carcinoma.

Pathways for Lung Combined Type Small Cell Carcinoma

Pathways related to Lung Combined Type Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 SYP NCAM1 GFAP
2 11.02 NCAM1 MME
3 10.7 SYP NCAM1 GFAP

GO Terms for Lung Combined Type Small Cell Carcinoma

Cellular components related to Lung Combined Type Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection terminus GO:0044306 8.62 SYP MME

Sources for Lung Combined Type Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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