Lung Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LNG099 MIFTS: 62	Lung Disease Categories: Blood diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Lung Disease

MalaCards integrated aliases for Lung Disease:

Name: Lung Disease ¹² ¹⁵ ¹⁷

Lung Diseases ⁵⁴ ⁴² ⁴⁴ ¹⁵ ⁷¹

Abnormality of the Lung ⁶

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the respiratory system

Lung diseases due to external agents

Other diseases of the respiratory system

Other respiratory disorders

Other disorders of lung

External Ids:

Disease Ontology ¹² DOID:850

MeSH ⁴⁴ D008171

NCIt ⁵⁰ C3198

SNOMED-CT ⁶⁷ 266374002

ICD10 ³² J60-J70 J98.4

EFO ¹⁷ EFO_0003818

UMLS ⁷¹ C0024115

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Summaries for Lung Disease

MedlinePlus : ⁴² When you breathe, your lungs take in oxygen from the air and deliver it to the bloodstream. The cells in your body need oxygen to work and grow. During a normal day, you breathe nearly 25,000 times. People with lung disease have difficulty breathing. Millions of people in the U.S. have lung disease. If all types of lung disease are lumped together, it is the number three killer in the United States. The term lung disease refers to many disorders affecting the lungs, such as asthma, COPD, infections like influenza, pneumonia and tuberculosis, lung cancer, and many other breathing problems. Some lung diseases can lead to respiratory failure. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Lung Disease, also known as lung diseases, is related to interstitial lung disease and pulmonary disease, chronic obstructive, and has symptoms including dyspnea, hemoptysis and apnea. An important gene associated with Lung Disease is SFTPC (Surfactant Protein C), and among its related pathways/superpathways are Metabolism of proteins and Toll-like Receptor Signaling Pathway. The drugs Cefuroxime and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and neutrophil, and related phenotypes are homeostasis/metabolism and mortality/aging

Disease Ontology : ¹² A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide.

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Related Diseases for Lung Disease

Diseases related to Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1403)

#	Related Disease	Score	Top Affiliating Genes
1	interstitial lung disease	33.8	TNF TERT SFTPD SFTPC SFTPB SFTPA2
2	pulmonary disease, chronic obstructive	33.3	TNF SFTPD SFTPB SERPINA1 IL1B IL10
3	pulmonary fibrosis, idiopathic	33.1	TNF TERT SFTPD SFTPC SFTPB SFTPA2
4	pulmonary fibrosis	33.1	TERT SFTPD SFTPC SFTPA2 SFTPA1 MUC5B
5	interstitial pneumonitis, desquamative, familial	33.1	SFTPD SFTPC SFTPB SFTPA2 MUC5B ABCA3
6	nontuberculous mycobacterial lung disease	33.0	TNF CFTR
7	alpha-1-antitrypsin deficiency	33.0	TNF SERPINA1 ELANE CXCL8 CFTR
8	cystic fibrosis	33.0	TNF SFTPD SFTPC SERPINA1 MUC5B IL1B
9	surfactant metabolism dysfunction, pulmonary, 1	32.9	SFTPC SFTPB ABCA3
10	rheumatoid arthritis interstitial lung disease	32.9	TNF SFTPD
11	anthracosis	32.9	TNF IL1B CXCL8
12	pulmonary hypertension	32.9	TNF SFTPC SFTPB SERPINA1 IL1B IL10
13	respiratory failure	32.8	TNF SFTPD SFTPC SFTPB SERPINA1 IL1B
14	idiopathic interstitial pneumonia	32.7	SFTPD SFTPC SFTPB SFTPA2 SFTPA1 MUC5B
15	bronchopulmonary dysplasia	32.7	SFTPB ELANE CXCL8
16	antisynthetase syndrome	32.7	MUC5B IL1B IFIH1
17	pneumonia	32.7	TNF SFTPD SFTPC SFTPB SERPINA1 MUC5B
18	bronchiolitis	32.7	TNF SFTPD IL1B IL10 CXCL8
19	extrinsic allergic alveolitis	32.7	SFTPD IL1B IL10 ELANE CXCL8
20	pneumoconiosis	32.7	TNF SERPINA1 MUC5B IL1B IL10 CXCL8
21	surfactant dysfunction	32.6	SFTPC SFTPB SFTPA1 ABCA3
22	pulmonary alveolar microlithiasis	32.6	SFTPD SFTPA2 ABCA3
23	asthma	32.5	TNF SFTPD SERPINA1 IL1B IL10 ELANE
24	bronchiolitis obliterans	32.5	TNF SFTPD IL10 CXCL8
25	cryptogenic organizing pneumonia	32.5	TNF SFTPD SFTPC SFTPA2 CXCL8
26	aspergillosis	32.5	TNF SFTPD SFTPA2 SFTPA1 IL1B IL10
27	silicosis	32.5	TNF SFTPD IL1B IL10 CXCL8
28	pulmonary alveolar proteinosis	32.5	TNF SFTPD SFTPC SFTPB SFTPA1 IL10
29	acute interstitial pneumonia	32.4	TNF TERT SFTPD SFTPC SFTPB SFTPA2
30	bronchiectasis	32.4	TNF SERPINA1 IL1B ELANE CXCL8 CFTR
31	respiratory distress syndrome in premature infants	32.4	SFTPC SFTPB SFTPA1 ABCA3
32	common variable immunodeficiency	32.3	TNF SERPINA1 IL1B IL10
33	sleep disorder	32.3	TNF IL1B IL10 CXCL8
34	meconium aspiration syndrome	32.3	TNF SFTPB CXCL8 ABCA3
35	pulmonary immaturity	32.2	SFTPD SFTPC SFTPB SFTPA2 SFTPA1 ABCA3
36	bronchitis	32.2	TNF SERPINA1 IL1B IL10 ELANE CXCL8
37	bagassosis	32.2	TNF IL1B CXCL8
38	connective tissue disease	32.2	TNF SFTPD IL1B IL10 CXCL8
39	nonspecific interstitial pneumonia	32.2	SFTPD SFTPC MUC5B IFIH1 ABCA3
40	klebsiella pneumonia	32.2	TNF IL1B IL10 CXCL8
41	pulmonary hemosiderosis	32.1	SFTPB ABCA3
42	myositis	32.0	TNF IL1B IFIH1 CXCL8
43	adult respiratory distress syndrome	32.0	TNF SFTPD SFTPC SFTPB IL1B IL10
44	autoimmune disease	31.8	TNF IL1B IL10 IFIH1 CXCL8
45	mycobacterium abscessus	31.8	TNF SERPINA1 CXCL8 CFTR
46	gastroesophageal reflux	31.7	TNF TERT IL1B ELANE CXCL8
47	exanthem	31.6	TNF IL1B IL10 IFIH1 CXCL8
48	pulmonary edema	31.6	TNF IL1B IL10 CXCL8 CFTR
49	enterocolitis	31.6	TNF IL10 CXCL8
50	sleep apnea	31.6	TNF IL1B IL10 CXCL8

Graphical network of the top 20 diseases related to Lung Disease:

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Symptoms & Phenotypes for Lung Disease

UMLS symptoms related to Lung Disease:

dyspnea, hemoptysis, apnea, snoring, coughing, labored breathing

MGI Mouse Phenotypes related to Lung Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.17	ABCA3 CFTR DYNC2H1 ELANE IFIH1 IL10
2	mortality/aging	MP:0010768	10.06	ABCA3 CFTR DYNC2H1 ELANE IFIH1 IL10
3	immune system	MP:0005387	10.03	CFTR ELANE IFIH1 IL10 IL1B ITGA3
4	neoplasm	MP:0002006	9.5	ELANE IL10 IL1B ITGA3 SFTPC TERT
5	respiratory system	MP:0005388	9.4	ABCA3 CFTR DYNC2H1 IL10 ITGA3 MUC5B

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Drugs & Therapeutics for Lung Disease

Drugs for Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 600)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cefuroxime

Approved

Phase 4

55268-75-2

5361202 5479529

Clotrimazole

Approved, Vet_approved

Phase 4

23593-75-1

2812

Miconazole

Approved, Investigational, Vet_approved

Phase 4

22916-47-8

4189

Beractant

Approved

Phase 4

108778-82-1

Iron

Approved

Phase 4

7439-89-6

23925 29936

Sirolimus

Approved, Investigational

Phase 4

53123-88-9

5284616 6436030

Simvastatin

Approved

Phase 4

79902-63-9

54454

Liraglutide

Approved

Phase 4

204656-20-2

44147092

Caspofungin

Approved

Phase 4

162808-62-0, 179463-17-3

468682 2826718

Penicillin G

Approved, Vet_approved

Phase 4

61-33-6

5904

Ethinyl Estradiol

Approved

Phase 4

57-63-6

5991

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Clavulanate

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Norgestimate

Approved, Investigational

Phase 4

35189-28-7

6540478

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

68602 5311068

Orange

Approved

Phase 4

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Rifampicin

Approved

Phase 4

13292-46-1

5458213 5381226

Mycophenolic acid

Approved

Phase 4

24280-93-1

446541

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

Tacrolimus

Approved, Investigational

Phase 4

104987-11-3

445643 439492 6473866

Everolimus

Approved

Phase 4

159351-69-6

6442177 70789204

Ledipasvir

Approved

Phase 4

1256388-51-8

67505836

Palivizumab

Approved, Investigational

Phase 4

188039-54-5

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Oxymetazoline

Approved, Investigational

Phase 4

1491-59-4

4636

Phenylephrine

Approved

Phase 4

59-42-7

6041

Olodaterol

Approved

Phase 4

868049-49-4

Theophylline

Approved

Phase 4

58-55-9

2153

Bisoprolol

Approved

Phase 4

66722-44-9

2405

Fosinopril

Approved

Phase 4

98048-97-6

55891

Ketoconazole

Approved, Investigational

Phase 4

65277-42-1

47576

Lactitol

Approved, Investigational

Phase 4

585-86-4

157355

Selenium

Approved, Investigational, Vet_approved

Phase 4

7782-49-2

Norflurane

Approved, Experimental

Phase 4

811-97-2

Desflurane

Approved

Phase 4

57041-67-5

42113

Sultamicillin

Approved, Investigational

Phase 4

76497-13-7

Dopamine

Approved

Phase 4

51-61-6, 62-31-7

681

Celiprolol

Approved, Investigational

Phase 4

56980-93-9

Fluconazole

Approved, Investigational

Phase 4

86386-73-4

3365

Anidulafungin

Approved, Investigational

Phase 4

166663-25-8

166548

Bupropion

Approved

Phase 4

34911-55-2, 34841-39-9

444

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

5743

Remifentanil

Approved

Phase 4

132875-61-7

60815

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Nintedanib

Approved

Phase 4

656247-17-5

56843413

Cyclophosphamide

Approved, Investigational

Phase 4

50-18-0, 6055-19-2

2907

Interventional clinical trials:

(show top 50) (show all 3614)

#	Name	Status	NCT ID	Phase	Drugs
1	Antibiotic Treatment of Patients With Chronic Obstructive Lung Disease: A Prospective, Randomized, Double-Blind Placebo-Controlled Study of Intermittent, Prophylactic Antibiotic Treatment With Azithromycin	Unknown status	NCT00132860	Phase 4	azithromycin
2	Use of the Endothelin-1 Antagonist Bosentan in Patients With Established Pulmonary Hypertension and Fibrotic Lung Disease. - A Randomised, Placebo-Controlled, Double-Blinded Study.	Unknown status	NCT00637065	Phase 4	Bosentan;Placebo
3	Randomized Controlled Trial of Pirfenidone in Patients With Progressive Interstitial Lung Disease Associated With Clinically Amyopathic Dermatomyositis	Unknown status	NCT02821689	Phase 4	Pirfenidone
4	Long-Term Oxygen Therapy (LTOT) in Chronic Obstructive Pulmonary Disease (COPD) Patients With Moderate Chronic Hypoxemia and Chronic Heart Failure (CHF)	Unknown status	NCT00668408	Phase 4
5	Comparison of Efficacy Different Treatment Regimens in Pulmonary Hypertension Secondary to Lung Disease and or Hypoxia	Unknown status	NCT01449253	Phase 4	Sildenafil;Bosentan
6	Prevention of Chronic Lung Disease (CLD) in Preterm Infants -A New Therapeutic Regimen	Unknown status	NCT00883532	Phase 4	budesonide;surfactant and air (placebo)
7	Inspiratory Capacity and HRCT Comparison of Nebulized Arformoterol (Brovana) vs. Dry-powder Inhaler Salmeterol (Serevent)	Unknown status	NCT01361984	Phase 4	Nebulized arformoterol;Salmeterol
8	Comparing Treatment Efficacy With High and Medium Dose of Fluticasone in Combination With Salmeterol in COPD Patients	Unknown status	NCT01131806	Phase 4	fluticasone/ salmeterol 125/25 mcg/puff;fluticasone/ salmeterol 250/25 mcg/puff
9	Pulmonary Effects of the Combination of Metoprolol and Formoterol in COPD	Unknown status	NCT00288548	Phase 4	Metoprolol
10	Differences of Small Airways Function Between Chronic Obstructive Pulmonary Disease(COPD) and Asthma-copd Overlap(ACO)	Unknown status	NCT03563001	Phase 4	Budesonide(160ug) and Formoterol(4.5ug) bid
11	Efficacy and Safety of Tulobuterol Patch Combined With Tiotropium Bromide for Relieving Dyspnea Symptom of Chronic Obstructive Pulmonary Disease	Unknown status	NCT01465906	Phase 4	tulobuterol;Tiotropium Bromide;tiotropium bromide
12	Seasonal Influenza Vaccine, Quadrivalent Versus Trivalent in Patients With Advanced Chronic Obstructive Pulmonary Disease	Unknown status	NCT02563184	Phase 4
13	Pulmonary Gas Exchange Response to Indacaterol in Stable Symptomatic Chronic Obstructive Pulmonary Disease Patients	Unknown status	NCT02547558	Phase 4	Indacaterol
14	A Multi-Center, Prospective, Clinical Trial Designed to Study the Efficacy of One-Way Valve Implantation Based on a New Treatment Algorithm in Patients With Heterogeneous Emphysema	Unknown status	NCT00730301	Phase 4
15	Impact of Exercise on Lung Function in Patients With Chronic Obstructive Pulmonary Disease	Unknown status	NCT03551197	Phase 4	Budesonide and formoterol bid
16	Improving Inhaler Treatment and Small Airways Assessment in Chronic Obstructive Pulmonary Disease (COPD)	Unknown status	NCT01721291	Phase 4	SALBUTAMOL
17	Effects of GLP-1 Receptor Agonist Treatment on Pulmonary Function and Quality of Life in Obese Patients With Chronic Obstructive Pulmonary Disease.	Unknown status	NCT03466021	Phase 4	Liraglutide;Placebo
18	Inhaled Iloprost for Disproportionate Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease	Unknown status	NCT01116063	Phase 4	Inhaled iloprost
19	The Lung Attack Alert Study	Unknown status	NCT01107613	Phase 4
20	Advair - CRP Study	Unknown status	NCT00120978	Phase 4	Advair;Flovent
21	Prospective, Open-label Study of the Efficacy and Safety of Caspofungin for the Treatment of Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease	Unknown status	NCT01499433	Phase 4	caspofungin
22	Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Roflumilast on Endothelial Function in Patients With Chronic Obstructive Pulmonary Disease	Unknown status	NCT01595750	Phase 4	Roflumilast 500;Placebo
23	Doxycycline and Airway Inflammation in COPD: A Randomised Placebo Controlled Trial Studying the Effects of Doxycycline on Airway Inflammation in Patients With Moderate and Severe Stable COPD.	Unknown status	NCT00857038	Phase 4	Doxycycline;Placebo
24	Long-term Effect of an Health Education Program on Daily Physical Activity in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease	Unknown status	NCT02924870	Phase 4
25	Description of the Ability to Learn How to Handle Inhaler Devices in COPD	Unknown status	NCT02813200	Phase 4	Seretide® Diskus® 500/550 μg;Ultibro® Breezhaler® 110/50 μg;Spiriva® Respimat® 2,5 μg
26	Efficacy and Safety of Salmeterol/Fluticasone Propionate vs Ipratropium/Albuterolin Chinese Patients With Moderate-to-severe COPD.	Unknown status	NCT01243788	Phase 4	Salmeterol/Fluticasone Propionate
27	Acute Effect of Sildenafil on Exercise Tolerance and Functional Capacity in COPD, IPF and Post Pneumonectomy Patients	Unknown status	NCT01382368	Phase 4	Sildenafil
28	Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Chronic Obstructive Pulmonary Disease Phenotype	Unknown status	NCT01431625	Phase 4
29	Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study.	Unknown status	NCT00331656	Phase 4
30	Utility of the AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation Assessed by the Chartis System	Unknown status	NCT01460108	Phase 4
31	Inspiratory Muscle Training for Dyspneic Patients With COPD-HF Overlap: a Multicenter, Randomized Controlled Trial	Unknown status	NCT02579200	Phase 4
32	Evaluation and Treatment of Small Airways in COPD	Unknown status	NCT02526758	Phase 4	beclomethasone;formoterol;budesonide
33	Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections. Can Measurement of Procalcitonin Reduce the Use of Antibiotics?	Unknown status	NCT02171338	Phase 4
34	Adherence to Therapy in COPD Patients Under Dose Escalation of Roflumilast	Unknown status	NCT02018432	Phase 4	Roflumilast escalation dosage;Roflumilast conventional dosage
35	The Effects of Simvastatin in Patients With Chronic Obstructive Pulmonary Disease	Unknown status	NCT00680641	Phase 4	Simvastatin;Placebo
36	Exacerbation's Prevention in Patients With COPD in GOLD IV Stage (Very Severe) With Non Invasive Mechanical Ventilation	Unknown status	NCT01481727	Phase 4
37	Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients	Unknown status	NCT02416778	Phase 4	Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
38	Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation	Unknown status	NCT01513655	Phase 4
39	An Efficacy Study of Benzalkonium Chloride Solution Clearing the Oral Colonized Bacterium in Hospitalized Patients With COPD	Unknown status	NCT02269800	Phase 4	Benzalkonium chloride solution;Normal saline
40	Evaluate the Efficacy of Xuebijing Injection in Acute Exacerbations of COPD：a Multicentre Randomised Controlled Trial	Unknown status	NCT02937974	Phase 4	Xuebijing;Placebo
41	Utilizing Wearable Device to Observe the Clinical Response of COPD Patients Treated With Combined Bronchodilator and Home-based Pulmonary Rehabilitation Program	Unknown status	NCT03364829	Phase 4	Indacaterol/Glycopyrronium
42	Effects of Nutritional Supplementation in Malnourished Patients in Stable COPD:a Randomised Controlled Trial	Unknown status	NCT02197871	Phase 4
43	Interstitial Fibrosis in Protocol Biopsies of Renal Allografts: A Prospective, Randomised Trial of Sirolimus Versus Cyclosporine.(Fibrasic)	Unknown status	NCT00493194	Phase 4	sirolimus;cyclosporine;daclizumab
44	MAESTRAL - A Prospective, Multinational, Multicenter, Randomized, Double Blind, Double Dummy, Controlled Study Comparing the Efficacy and Safety of Moxifloxacin to That of Amoxicillin Clavulanic Acid for the Treatment of Subjects With Acute Exacerbations of Chronic Bronchitis.	Completed	NCT00656747	Phase 4	Avelox (Moxifloxacin, BAY12-8039);Amoxicillin clavulanic acid
45	Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations: A Randomized Controlled Trial	Completed	NCT02843698	Phase 4	Dexmedetomidine;Normal saline
46	Effects of Pulmonary Rehabilitation in Interstitial Lung Diseases: a Prospective Randomized Controlled Trial	Completed	NCT00882817	Phase 4
47	Digital Auscultation Tool - Development of an Innovative Approach - Using Modern Technologies - to Improve the Diagnosis of Rare Lung Diseases - Expanded Data Collection Idiopathic Pulmonary Fibrosis	Completed	NCT03503188	Phase 4
48	Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease	Completed	NCT02622022	Phase 4	Morphine hydrochloride
49	ANTEAB: a Study of Early Antibiotherapy in the ICU Management of Acute Exacerbations of COPD	Completed	NCT00190437	Phase 4	Amoxicillin-clavulanic
50	GR Activity in Induced Sputum Macrophages, and a Change in Inflammatory Biomarkers 2-hours After a Single Dose of Either Symbicort®/Budesonide/Formoterol or in Chronic Obstructive Pulmonary Disease (COPD)	Completed	NCT01787097	Phase 4	Symbicort® total dose 400ug/12ug;Symbicort® total dose 800ug/24ug;Formoterol 24ug;BUD total dose 800ug

Search NIH Clinical Center for Lung Disease

Cochrane evidence based reviews: lung diseases

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Genetic Tests for Lung Disease

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Anatomical Context for Lung Disease

MalaCards organs/tissues related to Lung Disease:

⁴⁰

Lung, Endothelial, Neutrophil, T Cells, Bone Marrow, Skeletal Muscle, Skin

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Publications for Lung Disease

Articles related to Lung Disease:

(show top 50) (show all 43555)

#	Title	Authors	PMID	Year
1	Veno-Venous Extracorporeal Membrane Oxygenation in COVID-19-Where Are We Now? ⁴²	Putowski Z...Krzych LJ	33525739	2021
2	Prone positioning as an emerging tool in the care provided to patients infected with COVID-19: a scoping review. ⁴²	Araujo MS...Medeiros SM	33439949	2021
3	Exercise, Immune System, Nutrition, Respiratory and Cardiovascular Diseases during COVID-19: A Complex Combination. ⁴²	Scudiero O...Frisso G	33494244	2021
4	Decreased Cyp2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases. ⁵⁴ ⁶¹	Helmig S...Schneider J	20514434	2010
5	Surfactant protein (SP)-A and SP-D as antimicrobial and immunotherapeutic agents. ⁵⁴ ⁶¹	Awasthi S	20230362	2010
6	Adalimumab-induced acute pneumonitis in a patient with rheumatoid arthritis. ⁶¹ ⁵⁴	Dascalu C...Bandagi S	20511978	2010
7	Characteristics of disorders associated with genetic mutations of surfactant protein C. ⁵⁴ ⁶¹	Thouvenin G...Epaud R	20403820	2010
8	Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition. ⁵⁴ ⁶¹	Selige J...Dunkern T	20082309	2010
9	Nrf2 protects against airway disorders. ⁵⁴ ⁶¹	Cho HY...Kleeberger SR	19646463	2010
10	The NF-kappaB signaling in cystic fibrosis lung disease: pathophysiology and therapeutic potential. ⁵⁴ ⁶¹	Bodas M...Vij N	20423679	2010
11	Proline-Glycine-Proline (PGP) and High Mobility Group Box Protein-1 (HMGB1): Potential Mediators of Cystic Fibrosis Airway Inflammation. ⁶¹ ⁵⁴	Gaggar A...Blalock JE	20448817	2010
12	Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis. ⁶¹ ⁵⁴	Farberman MM...Ferkol T	19679607	2010
13	4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. ⁵⁴ ⁶¹	Mulchande J...Moreira R	19904934	2010
14	Development of carbohydrate-derived inhibitors of acid sphingomyelinase. ⁶¹ ⁵⁴	Roth AG...Arenz C	20005726	2010
15	Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease. ⁶¹ ⁵⁴	Greene CM...McElvaney NG	19762563	2010
16	Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients. ⁶¹ ⁵⁴	Maver A...Peterlin B	20082271	2010
17	TNFalpha-induced GM-CSF release from human airway smooth muscle cells depends on activation of an ET-1 autoregulatory positive feedback mechanism. ⁶¹ ⁵⁴	Knobloch J...Koch A	19850966	2009
18	Surfactant protein C in canine pulmonary fibrosis. ⁵⁴ ⁶¹	Eriksson M...Johansson J	19747194	2009
19	Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. ⁵⁴ ⁶¹	Kolosionek E...Pullamsetti SS	19759179	2009
20	Pulmonary nodulosis and aseptic granulomatous lung disease occurring in patients with rheumatoid arthritis receiving tumor necrosis factor-alpha-blocking agent: a case series. ⁶¹ ⁵⁴	Toussirot E...Cri L	19797509	2009
21	Prevalence and clinical significance of auto-antibodies in adults with cystic fibrosis. ⁶¹ ⁵⁴	Lachenal F...Durieu I	19443536	2009
22	Methemoglobin to cumulative nitric oxide ratio and response to inhaled nitric oxide in PPHN. ⁵⁴ ⁶¹	Pabalan MJ...Lakshminrusimha S	19554014	2009
23	Histone deacetylase-2 and airway disease. ⁶¹ ⁵⁴	Barnes PJ	19812111	2009
24	Long-acting local anesthetics attenuate FMLP-induced acute lung injury in rats. ⁵⁴ ⁶¹	Schley MT...Konrad CJ	19690261	2009
25	Natriuretic peptides for the prediction of severely impaired peak VO2 in patients with lung disease. ⁶¹ ⁵⁴	Maeder MT...Mueller C	19375295	2009
26	New surfactant protein C gene mutations associated with diffuse lung disease. ⁶¹ ⁵⁴	Guillot L...Feldmann D	19443464	2009
27	Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. ⁶¹ ⁵⁴	Sly PD...Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST-CF)	19372250	2009
28	Expression of MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease. ⁵⁴ ⁶¹	Safranek J...Treska V	19596921	2009
29	Association of transforming growth factor beta1 gene polymorphisms and asbestos-induced fibrosis and tumors. ⁶¹ ⁵⁴	Helmig S...Schneider J	19349911	2009
30	IL1B polymorphisms modulate cystic fibrosis lung disease. ⁶¹ ⁵⁴	Levy H...Weiss ST	19431193	2009
31	Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis. ⁵⁴ ⁶¹	Haggie PM...Verkman AS	19329540	2009
32	Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3. ⁶¹ ⁵⁴	Armstrong L...Millar AB	19292764	2009
33	Generation of bleomycin-induced lung fibrosis is independent of IL-16. ⁵⁴ ⁶¹	Glass WG...Murray LA	19232499	2009
34	Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. ⁵⁴ ⁶¹	Gu Y...Karp CL	19242412	2009
35	Association of MBL2, TGF-beta1 and CD14 gene polymorphisms with lung disease severity in cystic fibrosis. ⁵⁴ ⁶¹	Faria EJ...Bertuzzo CS	19466271	2009
36	Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis. ⁶¹ ⁵⁴	Haggie PM...Verkman AS	19136560	2009
37	Exhaled nitric oxide levels in alpha-1-antitrypsin PiMZ subjects. ⁵⁴ ⁶¹	Malerba M...Radaeli A	19019191	2009
38	Genetic association of SP-C with duration of preterm premature rupture of fetal membranes and expression in gestational tissues. ⁵⁴ ⁶¹	Salminen A...Hallman M	19735006	2009
39	Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency. ⁶¹ ⁵⁴	Petrache I...Campos M	19707408	2009
40	Transcription expression and clinical significance of TTF-1 mRNA in pleural effusion of patients with lung cancer. ⁵⁴ ⁶¹	Jiang B...Wang SC	18855882	2008
41	Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. ⁶¹ ⁵⁴	Hartl D...Roos D	19017998	2008
42	Clinical importance of bronchoalveolar lavage fluid and blood cytokines, surfactant protein D, and Kerbs von Lungren 6 antigen in idiopathic pulmonary alveolar proteinosis. ⁵⁴ ⁶¹	Lin FC...Chang SC	19046553	2008
43	Genetic variations in inflammatory mediators influence lung disease progression in cystic fibrosis. ⁶¹ ⁵⁴	Corvol H...Clement A	19009622	2008
44	Gastrin-releasing peptide, immune responses, and lung disease. ⁵⁴ ⁶¹	Degan S...Sunday ME	19076373	2008
45	Update on gene modifiers in cystic fibrosis. ⁶¹ ⁵⁴	Collaco JM...Cutting GR	18812833	2008
46	Potential role of high-mobility group box 1 in cystic fibrosis airway disease. ⁶¹ ⁵⁴	Rowe SM...Blalock JE	18658107	2008
47	Tumor necrosis factor-alpha in airway secretions from cystic fibrosis patients upregulate endothelial adhesion molecules and induce airway epithelial cell apoptosis: implications for cystic fibrosis lung disease. ⁵⁴ ⁶¹	Mitola S...De Rose V	19144271	2008
48	Calgranulin B (S100A9) levels in bronchoalveolar lavage fluid of patients with interstitial lung diseases. ⁵⁴ ⁶¹	Bargagli E...Rottoli P	18784990	2008
49	[Clinical value of combined detection of serum tumor markers in lung cancer diagnosis]. ⁵⁴ ⁶¹	Chen F...Liu D	19024326	2008
50	DNA vector augments inflammation in epithelial cells via EGFR-dependent regulation of TLR4 and TLR2. ⁵⁴ ⁶¹	Liu K...Bozinovski S	18403779	2008

Sources

Genes for Lung Disease

Genes related to Lung Disease (0 elite genes):

(show top 50) (show all 113)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	SFTPC	Surfactant Protein C	Protein Coding	43.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	19443464 14977415 16782390 (more) 17121584 15709974 14525980 15039969 16042774 16910460 18405368 20403820 15022133 12667827 15111052 9813382 19747194 17429902 19281242 14770296 16423261 12537318 19735006 12176392 15756222
2	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	35.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Variants (show sections)	20423679 9363079 16678503 (more) 9272738 17443603 9799593 9921909 12677168 12001283 11069835 9135733 9781011 16418321 16690975 10773783 18045644 17202292 9725922 11875272 10958769 9154877 19242412 9551612 12651880 14671928 18515557 7510983 9135734 16426904 16455659 15952991 15771606 14760158 12503104 11147574 10872419 10596703 18424453 15996905 16207846 16004694 15463928 12940920 12475759 11354633 10602380 12689922 10325907 8825494 7543317 7523956 20028935 19329540 16614352 16266832 17332481 17033796 16571124 16207791 16025767 11773234 12052305 11737931 10872417 10503604 8981951 7542778 19136560 19092437 14671931 15991075 15151509 12560856 8612275 9363078 19603002 18474670 18782827 9466061 9101293 7792437 7521937 17584036 15004288 14719996 10472642 10401194 8947061 1715308 1713908 20420703 18812833 18324338 17218617 16891388 9761762 7542031 19443536 15582124
3	SFTPB	Surfactant Protein B	Protein Coding	33.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	7491219 14977415 10960490 (more) 15790313 11041444 15027668 11273820 12784301 11202476 15985750 16641205 17498296 15976379 10571948 12356334 9813382 18929160 17429902 16042774 15022133 16423261 12537318 7832777 18405368 9623679 10445627
4	ITGA3	Integrin Subunit Alpha 3	Protein Coding	30.67	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
5	FARSB	Phenylalanyl-TRNA Synthetase Subunit Beta	Protein Coding	29.93	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
6	ABCA3	ATP Binding Cassette Subfamily A Member 3	Protein Coding	29.27	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Variants (show sections)	16982851 15985750 17127271
7	DYNC2H1	Dynein Cytoplasmic 2 Heavy Chain 1	Protein Coding	28.97	Likely pathogenic ⁶ DISEASES inferred ¹⁵
8	NSMCE3	NSE3 Homolog, SMC5-SMC6 Complex Component	Protein Coding	28.11	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
9	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	25.53	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18563170 10200141 11712746 (more) 7491556 11527824 9316287 1596015 7712280 8677789 14720072 8941999 9060460 9536833 9893038 8678788 10704089 10022265 9949625 7478787 8396001 16214322 15547537 11861936 15222634 11546973 11269653 8165067 16257194 16085794 10423406 9010273 1755373 19788733 9395718 19748599 19046553 19009622 15909061 16750994 11713357 10806959 9826354 8773587 8680382 11153595 10213466 7907692 10462040 10853853 9685620 9761763
10	SERPINA1	Serpin Family A Member 1	Protein Coding	25.17	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	17654345 7606551 7923455 (more) 18250185 20170533 17659342 20090075 8865799 15821195 15888825 7910401 12426287 19707397 9570144 9346392 19251783 15612581 15115878 10472171 19707408 18842915 16608528 15820772 18941444 17906067 16260177 16088534 11760819 9441132 19783716 19019191 18323534 20486818 15775753 15271689 10430615 7820538 16085464 11093698 16225408 16617455 18515255 2030926
11	SFTPD	Surfactant Protein D	Protein Coding	25.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10897675 16684127 16517507 (more) 16472150 14612363 14582909 17544823 18211966 9813383 9813381 11667972 11407696 16224252 16361352 16314824 8520747 19075981 16130114 9844346 20230362 15022133 20151281 17511270 19540617 19046553 12853121 15700120 18785967 17503247 17565019 12953146 16406431
12	ELANE	Elastase, Neutrophil Expressed	Protein Coding	24.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12800053 11834675 8256917 (more) 2187705 18250185 9030096 12771009 7638807 7473596 12615618 1433188 9719317 12162104 16799086 8102834 7912452 12853121 11007574 10857381 7952565 1623739 19725099 17850059 18757703 16719916 11868825 10749744 10464461 7912987 7516152 19372250 18699987 19904934 18211966 9035606 7712280 2119977 9417158 16257194 9316287 17299603 11527014 11313771 10930356 10879957 7656388 12802707 10712347 7996376 14594730 8616573 9311513 9834131
13	TNF	Tumor Necrosis Factor	Protein Coding	23.78	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15805183 1892644 11536154 (more) 11555378 17926095 12176706 1634820 19641295 10657935 10846556 2162537 9410434 2030926 9462189 9700092 10607801 12588664 16291871 19562291 8624250 8415254 19337437 17977770 12475802 10704089 8464851 17644942 16214322 20511978 19916860 15989786 18270925 17567674 12849708 9736227 9691696 11159047 9271310 7542280 8144974 17509552 17290043 15183075 8629860 1296468 1888449 2155556 19292764 19144271 19046553 17034639 15790988 11546973 1630052 19009622 16511933 12566517 11713357 9068814 8680382 8678788 19797509 19835594 10569191 9870925 10464849 11202234 11133380
14	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	23.76	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
15	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	23.43	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
16	TERT	Telomerase Reverse Transcriptase	Protein Coding	23.4	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
17	SFTPA2	Surfactant Protein A2	Protein Coding	22.81	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
18	SFTPA1	Surfactant Protein A1	Protein Coding	22.79	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
19	IL1B	Interleukin 1 Beta	Protein Coding	22.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10846556 1630052 19431193 (more) 9536833 11241561 2030926 10607801 10873160 19046553 9736227 15989786 12195834 9691696 8629860 2394137 12588664 7939927 10704089 8360496
20	IL10	Interleukin 10	Protein Coding	21.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10685991 12463318 17472748 (more) 11133380 10453017 10806959 19046553 8520783 19009622 11106053 8811054 12438678
21	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	21.27	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11591574 11710722 16809218 (more) 11295656 8678788 8680382 10384061 17908747 19046553
22	PRTN3	Proteinase 3	Protein Coding	20.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8352807 16719916
23	FLNA	Filamin A	Protein Coding	20.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
24	IFRD1	Interferon Related Developmental Regulator 1	Protein Coding	20.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
25	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	20.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19466271 16207846 19009622 (more) 10213466 8181807 19734317 8980960 15051419 8618178 16456242 12944979 12376363 12883307 11895471 16365456 12635140 8991985 18424453 19349911 17785866 9700098
26	MMP9	Matrix Metallopeptidase 9	Protein Coding	20.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19596921 12495928 16724695 (more) 14605041 12370004 12356580 15738294 20111696 12663332 12403873 12712078 12456387 19097983 11471571 15244229
27	MPO	Myeloperoxidase	Protein Coding	20.25	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16883063 15901828 15454881 (more) 19596067 12432558 1325737 7800958 9510666 10456969 10673177 10813590 16257194 10364739
28	GRP	Gastrin Releasing Peptide	Protein Coding	20.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19076373 12820318 11109801 (more) 10996422 18514066 11282430 1565825 20032442
29	TSC2	TSC Complex Subunit 2	Protein Coding	20.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders (show sections)	19596836 17114346
30	ELN	Elastin	Protein Coding	20	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	7784713 15955094 15631192 (more) 7921432 18346936 10464461 9142143 9719317 19762563
31	SERPINA3	Serpin Family A Member 3	Protein Coding	19.88	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
32	MIR21	MicroRNA 21	RNA Gene	19.84	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
33	NARS1	Asparaginyl-TRNA Synthetase 1	Protein Coding	19.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins (show sections)
34	CTSG	Cathepsin G	Protein Coding	19.79	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19679607 8352807 10879957
35	IL13	Interleukin 13	Protein Coding	19.78	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9448046 14703444 20521887
36	NKX2-1	NK2 Homeobox 1	Protein Coding	19.73	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18855882 15517377
37	NPPB	Natriuretic Peptide B	Protein Coding	19.72	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16415273 11788208 19375295 (more) 15054559 17086116 19459423 16148485 12693069 16442916 18089293 16323069 15173030 18768045 17588252 16644322 16053780 14586510 12615595 15302622 15841926
38	SLPI	Secretory Leukocyte Peptidase Inhibitor	Protein Coding	19.6	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8569039 11868825 17964057 (more) 7638807 7913712 18699987 7744180 16257194 8994529 9262369
39	IL5	Interleukin 5	Protein Coding	19.56	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11008103 10087872 12406662 (more) 8676086
40	COPA	COPI Coat Complex Subunit Alpha	Protein Coding	19.55	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
41	TSC1	TSC Complex Subunit 1	Protein Coding	19.51	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders (show sections)	10852420 18754697 11520735 (more) 17431222 11520734
42	EDN1	Endothelin 1	Protein Coding	19.32	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11686871 10065341 9284832 (more) 11887493 18307123 8092761 19690261 8894355 10576621 12740512 9736447 9551191 9357851 7665694 20082271 18296497 10873149 19850966 17627891 12193107 7837147 17379848 8630015 9196090 9918746 17620004 16766723 7836103 9372656
43	MBL2	Mannose Binding Lectin 2	Protein Coding	19.13	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18585026 11836800 18292811 (more) 15757259 17045845 10541506 15654829
44	CSF2	Colony Stimulating Factor 2	Protein Coding	19.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	1511959 9685620 11250057 (more) 18251786 8676086 10198353
45	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	19.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9192918 7537968
46	SERPINB1	Serpin Family B Member 1	Protein Coding	18.98	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12162104
47	PI3	Peptidase Inhibitor 3	Protein Coding	18.97	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11868825 17964057 11667971 (more) 16719916 15182352 11834675
48	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	18.95	DISEASES inferred ¹⁵ ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15140412 17433115 15563688
49	TLR2	Toll Like Receptor 2	Protein Coding	18.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16829623 19835594 16608528 (more) 18403779 17567674 18602432
50	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	18.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10384061

Sources

Variations for Lung Disease

ClinVar genetic disease variations for Lung Disease:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	DYNC2H1	NM_001377.3(DYNC2H1):c.5920G>T (p.Gly1974Ter)	SNV	Likely pathogenic	978635		11:103048330-103048330	11:103177601-103177601
2	DYNC2H1	NM_001377.3(DYNC2H1):c.9908T>C (p.Ile3303Thr)	SNV	Uncertain significance	978634		11:103114510-103114510	11:103243781-103243781

Sources

Expression for Lung Disease

Search GEO for disease gene expression data for Lung Disease.

Sources

Pathways for Lung Disease

Pathways related to Lung Disease according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁵ Show member pathways Post-translational protein modification ⁶⁵	13.66	SFTPD SFTPC SFTPB SFTPA2 SFTPA1 SERPINA1
2	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.94	TNF SFTPD SFTPA2 IL1B IL10 IFIH1
3	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²³ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²³ NOD-like Receptor Signaling Pathways ⁶⁴	12.64	TNF MUC5B IL1B CXCL8 CFTR
4	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.23	TNF MUC5B IL1B CXCL8 CFTR
5	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.19	TNF TERT IL1B IL10 CXCL8
6	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.11	TNF IL1B IL10 CXCL8
7	Phagosome ³⁶	12.07	SFTPD SFTPA2 SFTPA1 DYNC2H1
8	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.02	TNF SFTPD SFTPA1 IL1B CXCL8 CFTR
9	Yersinia infection ³⁶	12.01	TNF IL1B IL10 CXCL8
10	Interleukin-4 and 13 signaling ⁶⁵	11.91	TNF IL1B IL10 CXCL8
11	Amoebiasis ³⁶	11.83	TNF IL1B IL10 CXCL8
12	Rheumatoid arthritis ³⁶	11.78	TNF IL1B CXCL8
13	Diseases of metabolism ⁶⁵ Show member pathways Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) ⁶⁵ Defective CD320 causes methylmalonic aciduria ⁶⁵ Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) ⁶⁵ Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC ⁶⁵ Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD ⁶⁵ Defective TCN2 causes hereditary megaloblastic anemia ⁶⁵ Defects in cobalamin (B12) metabolism ⁶⁵ Defects in vitamin and cofactor metabolism ⁶⁵ Electron transport from NADPH to Ferredoxin ⁶⁵ Metabolic disorders of biological oxidation enzymes ⁶⁵	11.73	SFTPD SFTPC SFTPB SFTPA2 SFTPA1
14	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.71	TNF IL1B IL10
15	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.68	TNF IL1B IL10
16	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.67	TNF IL1B IL10
17	Pertussis ³⁶	11.61	TNF SFTPA2 SFTPA1 IL1B IL10 CXCL8
18	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.59	TNF IL1B CXCL8
19	Legionellosis ³⁶	11.54	TNF IL1B CXCL8
20	Malaria ³⁶	11.48	TNF IL1B IL10 CXCL8
21	Interleukin-10 signaling ⁶⁵	11.42	TNF IL1B IL10 CXCL8
22	FOXA1 transcription factor network ¹ Show member pathways FOXA transcription factor networks ¹	11.37	SFTPD SFTPA2 SFTPA1 SERPINA1
23	African trypanosomiasis ³⁶	11.31	TNF IL1B IL10
24	IL-10 Pathway ⁶³	11.28	TNF IL1B IL10
25	Cytokines and Inflammatory Response ¹	11.17	TNF IL1B IL10
26	Lung fibrosis ¹	11.08	TNF TERT SFTPC SFTPA2 SFTPA1 SERPINA1
27	Surfactant metabolism ⁶⁵ Show member pathways Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) ⁶⁵ Diseases associated with surfactant metabolism ⁶⁵	11.07	SFTPD SFTPC SFTPB SFTPA2 SFTPA1 ABCA3
28	Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) ⁶⁵ Show member pathways Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) ⁶⁵ Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) ⁶⁵ Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) ⁶⁵ Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) ⁶⁵	10.95	SFTPD SFTPC SFTPB SFTPA2 SFTPA1
29	G-protein signaling_Rap2B regulation pathway ²³	10.94	TNF ITGA3 IL1B IL10 CXCL8