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LICS
MCID: LNG105
MIFTS: 29
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Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome (LICS)
Categories:
Genetic diseases, Immune diseases, Infectious diseases, Respiratory diseases
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Aliases & Classifications for Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome
MalaCards integrated aliases for Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome:
Characteristics:OMIM:57
Inheritance:
autosomal recessive
Miscellaneous:
onset in first months of life four patients from 2 unrelated families have been reported (last curated december 2016) death in first years of life HPO:32
lung disease, immunodeficiency, and chromosome breakage syndrome:
Inheritance autosomal recessive inheritance Classifications:
MalaCards categories:
Global: Genetic diseases Infectious diseases Anatomical: Respiratory diseases Immune diseases |
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UniProtKB/Swiss-Prot
:
75
Lung disease, immunodeficiency, and chromosome breakage syndrome: An autosomal recessive chromosome breakage syndrome associated with severe, fatal lung disease in early childhood, following viral pneumonia. LICS is characterized by combined T and B-cell immunodeficiency. Some patients may have mild dysmorphic features.
MalaCards based summary : Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome, also known as lics, is related to beta-thalassemia and thalassemia. An important gene associated with Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome is NSMCE3 (NSE3 Homolog, SMC5-SMC6 Complex Component). Affiliated tissues include lung, b cells and t cells, and related phenotypes are failure to thrive and abnormal facial shape OMIM : 57 LICS is an autosomal recessive chromosome breakage syndrome characterized by failure to thrive in infancy, immune deficiency, and fatal progressive pediatric lung disease induced by viral infection. Some patients may have mild dysmorphic features (summary by van der Crabben et al., 2016). (617241) CDC : 3 Lice are parasitic insects that can be found on people’s heads, and bodies, including the pubic area. Human lice survive by feeding on human blood. Lice found on each area of the body are different from each other. The three types of lice that live on humans are: |
Diseases related to Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:
Graphical network of the top 20 diseases related to Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome:
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Symptoms via clinical synopsis from OMIM:57Clinical features from OMIM:617241Human phenotypes related to Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome:32 (show all 12)
GenomeRNAi Phenotypes related to Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome according to GeneCards Suite gene sharing:26
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MalaCards organs/tissues related to Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome:41
Lung,
B Cells,
T Cells,
Thymus
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Articles related to Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome:
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Genes related to Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome (1 elite genes): - Elite gene
- Cancer Census gene in COSMIC
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Search
GEO
for disease gene expression data for Lung Disease, Immunodeficiency, and Chromosome Breakage Syndrome.
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