MCID: LNG017
MIFTS: 50

Lung Giant Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Lung Giant Cell Carcinoma

MalaCards integrated aliases for Lung Giant Cell Carcinoma:

Name: Lung Giant Cell Carcinoma 11 14 16
Carcinoma, Giant Cell 43 71
Giant Cell Carcinoma of Lung 71
Giant Cell Lung Carcinoma 11
Giant Cell Carcinoma 11
Carcinoma Giant Cell 53

Classifications:



External Ids:

Disease Ontology 11 DOID:5583
MeSH 43 D018286
NCIt 49 C3779 C4452
SNOMED-CT 68 254631008 42596004
UMLS 71 C0206703 C0345960

Summaries for Lung Giant Cell Carcinoma

Disease Ontology: 11 A lung carcinoma that is located in large undifferentiated cells.

MalaCards based summary: Lung Giant Cell Carcinoma, also known as carcinoma, giant cell, is related to lung sarcomatoid carcinoma and epithelial-myoepithelial carcinoma, and has symptoms including fever, hemoptysis and dyspnea. An important gene associated with Lung Giant Cell Carcinoma is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Signal Transduction and Endometrial cancer. The drugs Nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include large undifferentiated cells, lung and pancreas, and related phenotypes are Reduced mammosphere formation and Increased cell migration

Related Diseases for Lung Giant Cell Carcinoma

Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 446)
# Related Disease Score Top Affiliating Genes
1 lung sarcomatoid carcinoma 30.3 NKX2-1 NAPSA KRT7 KRT5 KRAS EGFR
2 epithelial-myoepithelial carcinoma 30.2 KRT7 KRT5
3 angiosarcoma 30.1 VIM SERPINA3 KRAS
4 epithelioid sarcoma 30.0 VIM SERPINA3 KRT7
5 lung benign neoplasm 29.8 NKX2-1 KRT7 KRAS EGFR
6 malignant fibrous histiocytoma 29.8 VIM SERPINA3 CD68
7 small cell cancer of the lung 29.8 NKX2-1 MYC KRT7 EGFR
8 serous cystadenocarcinoma 29.8 NAPSA KRT7 KRAS
9 carcinosarcoma 29.7 VIM KRT7 KRAS EGFR
10 ovarian serous cystadenocarcinoma 29.7 SERPINA3 KRAS EGFR
11 endometrial adenocarcinoma 29.7 SERPINA3 KRT7 KRAS EGFR
12 mucoepidermoid carcinoma 29.7 VIM SERPINA3 KRT7 EGFR
13 squamous cell carcinoma 29.7 NKX2-1 MYC KRT7 KRAS EGFR
14 benign giant cell tumor 29.6 VIM SERPINA3 CD68
15 differentiated thyroid carcinoma 29.6 NKX2-1 KRAS ALK
16 liposarcoma 29.6 VIM MYC CD68
17 fibrous histiocytoma 29.5 VIM SERPINA3 CD68 ALK
18 lymphangitis 29.4 NKX2-1 KRT7 EGFR ALK
19 bronchiolo-alveolar adenocarcinoma 29.4 NKX2-1 KRT7 KRAS EGFR
20 breast ductal carcinoma 29.4 MYC KRT7 KRT5 EGFR
21 pancreatic cancer 29.4 VIM SERPINA3 MYC KRT7 KRAS IL6R
22 trachea carcinoma 29.3 NKX2-1 KRT7 KRT5 ALK
23 rhabdomyosarcoma 29.2 VIM MYC KRT7 KRAS EGFR ALK
24 endometrial cancer 29.2 MYC KRT7 KRAS GJA1 EGFR ALK
25 adenocarcinoma 29.1 NKX2-1 NAPSA KRT7 KRAS EGFR ALK
26 large cell carcinoma 28.9 NKX2-1 NAPSA KRT7 KRT5 KRAS EGFR
27 leukemia, acute myeloid 28.9 SERPINA3 MYC KRAS EGFR CXCL8 ALK
28 small cell carcinoma 28.9 NKX2-1 NAPSA KRT7 KRT5 EGFR ALK
29 pleomorphic carcinoma 28.6 NKX2-1 NAPSA KRT7 KRT5 KRAS EGFR
30 lung cancer susceptibility 3 28.6 NKX2-1 NAPSA MYC KRT7 KRAS EGFR
31 ovarian cancer 28.5 VIM MYC KRT7 KRAS IL6R GJA1
32 lung cancer 28.3 VIM SERPINA3 NKX2-1 NAPSA MYC KRT7
33 adenosquamous carcinoma 28.3 SERPINA3 NKX2-1 KRT7 KRT5 KRAS EGFR
34 large cell neuroendocrine carcinoma 28.3 NKX2-1 NAPSA KRT7 KRT5 KRAS EGFR
35 breast cancer 27.5 VIM SERPINA3 NKX2-1 MYC KRT7 KRT5
36 lung meningioma 10.3 VIM NKX2-1
37 epithelioid leiomyosarcoma 10.3 VIM SERPINA3
38 aspiration pneumonitis 10.3 SERPINA3 CXCL8
39 rare tumor 10.3
40 gallbladder signet ring cell adenocarcinoma 10.3 MYC KRT7
41 cervical mucinous adenocarcinoma 10.3 NAPSA KRT7
42 cervical clear cell adenocarcinoma 10.3 NAPSA KRT7
43 nephrogenic adenoma 10.3 NAPSA KRT7
44 ovarian endodermal sinus tumor 10.3 NAPSA KRT7
45 krukenberg carcinoma 10.3 NAPSA KRT7
46 urethral diverticulum 10.3 NAPSA KRT7
47 bronchus adenoma 10.3 NKX2-1 NAPSA
48 mucinous bronchioloalveolar adenocarcinoma 10.2 NKX2-1 KRT7
49 ovarian primitive germ cell tumor 10.2 NAPSA KRT7
50 ovarian mucinous adenocarcinoma 10.2 SERPINA3 KRT7

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to Lung Giant Cell Carcinoma

Symptoms & Phenotypes for Lung Giant Cell Carcinoma

UMLS symptoms related to Lung Giant Cell Carcinoma:


fever; hemoptysis; dyspnea; coughing

GenomeRNAi Phenotypes related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CXCL8 EGFR IL6R KRAS KRT7 MYC
2 Increased cell migration GR00055-A-1 8.96 GJA1
3 Increased cell migration GR00055-A-3 8.96 GJA1

MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.7 ALK EGFR IL6R KRAS MYC NKX2-1
2 normal MP:0002873 9.56 ALK EGFR GJA1 IL6R KRAS MYC
3 no phenotypic analysis MP:0003012 9.1 CD68 EGFR GJA1 KRAS MYC NKX2-1

Drugs & Therapeutics for Lung Giant Cell Carcinoma

Drugs for Lung Giant Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3 Immunoglobulins Phase 2
4 Immune Checkpoint Inhibitors Phase 2
5 Antibodies, Monoclonal Phase 2
6 Antibodies Phase 2
7 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
2 Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma Terminated NCT00568906

Search NIH Clinical Center for Lung Giant Cell Carcinoma

Cochrane evidence based reviews: carcinoma, giant cell

Genetic Tests for Lung Giant Cell Carcinoma

Anatomical Context for Lung Giant Cell Carcinoma

Organs/tissues related to Lung Giant Cell Carcinoma:

FMA: Large Undifferentiated Cells
MalaCards : Lung, Pancreas, Thyroid, Prostate, Salivary Gland, Colon, Cervix

Publications for Lung Giant Cell Carcinoma

Articles related to Lung Giant Cell Carcinoma:

(show top 50) (show all 417)
# Title Authors PMID Year
1
[Expression of connexin 43 in lung cancer and its correlation with E-cadherin]. 53 62
16834907 2006
2
Effective asymmetry in gap junctional intercellular communication between populations of human normal lung fibroblasts and lung carcinoma cells. 53 62
14656943 2004
3
Pleomorphic giant cell carcinoma of the esophagus with coexpression of cytokeratin and vimentin and neuroendocrine differentiation. 53 62
10629146 2000
4
Effect of interleukin-6 on the growth of human lung cancer cell line. 53 62
10374431 1998
5
[Differential expression and response of growth factors in metastatic variants of human pulmonary giant cell carcinoma cell line]. 53 62
10072879 1997
6
[Influence of transfection of sense- and antisense-TGF beta 1 gene on human pulmonary giant cell carcinoma cell proliferation]. 53 62
10743067 1997
7
[Effects of metalloproteinases-1 (TIMP-1) cDNA transfection on biological behaviors of PG cells]. 53 62
7987710 1994
8
Immunohistochemical features of giant cell carcinoma of the lung: patterns of expression of cytokeratins, vimentin, and the mucinous glycoprotein recognized by monoclonal antibody A-80. 53 62
1710080 1991
9
Joining of the c-myc gene and a line 1 family member on chromosome 8 in a human primary giant cell carcinoma of the lung. 53 62
2334929 1990
10
Pleomorphic giant cell carcinoma of the bladder: The diagnostic challenge of an unusual variant of urothelial carcinoma. 62
36257879 2022
11
Endometrial carcinoma with diffuse melanocytic differentiation: Clinicopathological and molecular analysis of a case with literature review and focus on differential diagnosis. 62
36174440 2022
12
Endometrial giant cell carcinoma: new insights from a morphological, immunohistochemical, and molecular analysis of three cases. 62
35305145 2022
13
Anaplastic thyroid carcinoma in a brush-tailed rock-wallaby (Petrogale penicillata). 62
35257364 2022
14
The glottic-subglottic laryngectomy: Surgical technique, oncological, and functional outcomes. 62
34542917 2022
15
Real-world treatment patterns and outcomes among patients with advanced non-small-cell lung cancer with spindle cell and/or giant cell carcinoma. 62
36324732 2022
16
[Long-term Survival Giant Cell Carcinoma of the Lung with Chest Wall Invasion by Multidisciplinary Therapy:Report of a Case]. 62
35249080 2022
17
Poorly Differentiated Cervical Squamous Cell Carcinoma Resembling Giant Cell Carcinoma of the Lung: Extreme Morphology of This Tumor and Its Clinical Course. 62
36089344 2022
18
Pleomorphic (giant cell) carcinoma revisited: A historical perspective and conceptual reappraisal. 62
34583859 2021
19
Giant Cell Carcinoma of the Endometrium: A Case Report of a Rare Entity with Aggressive Behavior. 62
34497258 2021
20
The importance of medical treatment before surgery in pleomorphic carcinoma of the lung: A case series study. 62
34392016 2021
21
Osteoclast-Like Giant Cell Tumors of the Pancreas: Clinical Characteristics, Genetic Testing, and Treatment Modalities. 62
34369897 2021
22
Successful treatment of metastatic bladder pleomorphic giant cell carcinoma with pembrolizumab. 62
34258526 2021
23
Programmed death ligand-1 expression levels, clinicopathologic features, and survival in surgically resected sarcomatoid lung carcinoma. 62
32929886 2021
24
Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features. 62
33640702 2021
25
Low digestive hemorrhage due to giant-cell lung carcinoma metastasis. 62
32988641 2021
26
Clinicopathological features and prognostic analysis of metastatic pulmonary sarcomatoid carcinoma: a SEER analysis. 62
33717562 2021
27
[Affinity chromatography based phosphoproteome research on lung cancer cells and its application]. 62
34227361 2021
28
Gene fusion characterisation of rare aggressive prostate cancer variants-adenosquamous carcinoma, pleomorphic giant-cell carcinoma, and sarcomatoid carcinoma: an analysis of 19 cases. 62
32639612 2020
29
Extremely Aggressive Behavior of a Completely Resected Case of Gallbladder Undifferentiated Carcinoma, Giant Cell Type: a Rare Case with Breast, Neck Nodes, and Subcutaneous Scalp Nodules Metastasis. 62
31155696 2020
30
Gestational pulmonary giant cell carcinoma - An autopsy report. 62
31736471 2020
31
Pulmonary Sarcomatoid Giant Cell Carcinoma with Paraneoplastic Hypertrophic Osteoarthropathy: A Case Report. 62
32968695 2020
32
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas diagnosed by endoscopic ultrasound guided biopsy. 62
32863866 2020
33
[Pleomorphic giant cell carcinoma of the prostate: report of a case]. 62
31594053 2019
34
[A Case Of cT3bN2M0 Pleomorphic Giant Cell Carcinoma of the Bladder without Recurrence after Neoadjuvant Chemotherapy and Radical Cystectomy for 4 Years]. 62
31697880 2019
35
Giant cell carcinoma of the lung presenting as an isolated cyst containing air: A case report. 62
31096508 2019
36
Osteoclast-type giant cell carcinoma of the urinary bladder: An unusual and aggressive variant of urothelial carcinoma. 62
30581755 2019
37
Uterine giant cell carcinoma: a case report and review of the literature. 62
31019844 2019
38
Osteoclast-like giant cell-rich carcinomas of the lung: a clinicopathological, immunohistochemical, and molecular study of 3 cases. 62
30447297 2019
39
Approaches to Tumor Classification in Pulmonary Sarcomatoid Carcinoma. 62
31824199 2019
40
Pulmonary Sarcomatoid carcinoma: a surgical diagnosis and prognostic factors. 62
31535704 2019
41
Postmortem Investigation of Immunohistochemical Staining and Gross Description of Sarcomatoid Carcinoma of the Lung in a Patient With Extreme Leukemoid Reaction. 62
31272237 2019
42
A Histologically Complete Response to Immunotherapy Using Pembrolizumab in a Patient with Giant Cell Carcinoma of the Lung: An Additional Report and Literature Review. 62
31737389 2019
43
Malignant Giant Cell Tumor of Soft Tissue: A Case Report of Intramuscular Malignant Giant Cell Carcinoma of the Tensor Fasciae Latae. 62
31245324 2019
44
[Current Status of Diagnosis and Treatment of Pulmonary Sarcomatoid Carcinoma]. 62
30591097 2018
45
HOXB13 is not expressed in pleomorphic giant cell carcinoma of the bladder. 62
29926185 2018
46
Letter to the editor: reply to Valeria Barresi "HOXB13 is not expressed in pleomorphic giant cell carcinoma of the bladder". 62
29934658 2018
47
Papillary thyroid carcinoma with pleomorphic tumor giant cells in a pregnant woman - a case report. 62
29976183 2018
48
A rare case of giant cell lung carcinoma with intracardiac extension via the pulmonary vein and thrombus formation. 62
29977517 2018
49
Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma. 62
30046230 2018
50
Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography-guided fine-needle aspiration cytology. 62
29399198 2018

Variations for Lung Giant Cell Carcinoma

Cosmic variations for Lung Giant Cell Carcinoma:

8 (show top 50) (show all 1546)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM86645186 RB1 lung,NS,carcinoma,giant cell carcinoma c.245C>A p.S82* 13:48307387-48307387 14
2 COSM150689102 RB1 lung,NS,carcinoma,giant cell carcinoma c.245C>A p.S82* 13:48307387-48307387 14
3 COSM111938756 EGFR lung,NS,carcinoma,giant cell carcinoma c.2438T>G p.L813R 7:55191822-55191822 14
4 COSM111332419 EGFR lung,NS,carcinoma,giant cell carcinoma c.2438T>G p.L813R 7:55191822-55191822 14
5 COSM147932132 EGFR lung,NS,carcinoma,giant cell carcinoma c.*563T>G p.? 7:55191822-55191822 14
6 COSM86748127 EGFR lung,NS,carcinoma,giant cell carcinoma c.2573T>G p.L858R 7:55191822-55191822 14
7 COSM102042323 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8009A>G p.? 16:72958974-72958974 11
8 COSM87291734 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 11
9 COSM102040476 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8037G>T p.? 16:72959002-72959002 11
10 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 11
11 COSM87290218 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 11
12 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 11
13 COSM126973051 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.770C>T p.P257L 11:102229729-102229729 11
14 COSM145028029 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1154C>T p.P385L 11:102229729-102229729 11
15 COSM128452039 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 11
16 COSM85237448 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1304C>T p.P435L 11:102229729-102229729 11
17 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 11
18 COSM127997731 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1256C>T p.P419L 11:102229729-102229729 11
19 COSM133274224 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1268C>T p.P423L 11:102229729-102229729 11
20 COSM90948266 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1202C>T p.P401L 11:102229729-102229729 11
21 COSM108017622 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 11
22 COSM95166535 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 11
23 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 11
24 COSM105839764 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 11
25 COSM106337415 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 11
26 COSM103711109 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1036A>C p.I346L 22:41653558-41653558 11
27 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 11
28 COSM134125623 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1114A>G p.M372V 19:43546970-43546970 11
29 COSM100781761 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.724A>T p.K242* 11:32392044-32392044 11
30 COSM111539040 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 11
31 COSM149728755 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 11
32 COSM130518653 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.673A>T p.K225* 11:32392044-32392044 11
33 COSM113475703 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 11
34 COSM111529696 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 11
35 COSM113484991 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 11
36 COSM147414475 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 11
37 COSM149739953 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 11
38 COSM148580942 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 11
39 COSM148593279 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 11
40 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 11
41 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 11
42 COSM147426277 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 11
43 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 11
44 COSM104050903 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 11
45 COSM105123686 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 11
46 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 11
47 COSM102763785 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 11
48 COSM99767946 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 11
49 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 11
50 COSM121848752 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 11

Expression for Lung Giant Cell Carcinoma

Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.

Pathways for Lung Giant Cell Carcinoma

Pathways related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1 13.51 VIM MYC KRAS IL6R GJA1 EGFR
2
Show member pathways
12.49 MYC KRAS EGFR ALK
3
Show member pathways
12.36 CXCL8 EGFR IL6R KRAS MYC
4 12.3 VIM KRT7 KRT5 GJA1
5
Show member pathways
11.96 MYC KRAS IL6R EGFR
6 11.85 VIM MYC GJA1
7 11.84 MYC KRAS IL6R EGFR
8
Show member pathways
11.76 MYC KRAS EGFR
9 11.61 MYC KRAS EGFR CXCL8
10 11.49 VIM MYC IL6R CXCL8
11 11.45 MYC GJA1 CXCL8
12 11.32 MYC IL6R CXCL8
13 11.18 MYC KRAS EGFR
14 11.08 VIM MYC GJA1 EGFR CXCL8
15 10.86 EGFR CXCL8
16 10.86 MYC KRAS EGFR CXCL8
17 10.64 VIM MYC

GO Terms for Lung Giant Cell Carcinoma

Biological processes related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cerebral cortex cell migration GO:0021795 9.46 NKX2-1 EGFR
2 intermediate filament organization GO:0045109 9.43 VIM KRT7 KRT5
3 positive regulation of gene expression GO:0010628 9.36 VIM NKX2-1 MYC KRAS GJA1 CXCL8

Sources for Lung Giant Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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