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MCID: LNG017
MIFTS: 43

Lung Giant Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Lung Giant Cell Carcinoma

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MalaCards integrated aliases for Lung Giant Cell Carcinoma:

Name: Lung Giant Cell Carcinoma 12 15
Carcinoma, Giant Cell 44 73
Giant Cell Carcinoma of Lung 73
Giant Cell Lung Carcinoma 12
Giant Cell Carcinoma 12
Carcinoma Giant Cell 55

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5583
MeSH 44 D018286
NCIt 50 C3779 C4452
SNOMED-CT 68 42596004
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Summaries for Lung Giant Cell Carcinoma

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Disease Ontology : 12 A lung carcinoma that is located in large undifferentiated cells.

MalaCards based summary : Lung Giant Cell Carcinoma, also known as carcinoma, giant cell, is related to hepatocellular carcinoma and cryptogenic organizing pneumonia, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with Lung Giant Cell Carcinoma is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. Affiliated tissues include lung, bone and colon, and related phenotypes are Reduced mammosphere formation and growth/size/body region

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Related Diseases for Lung Giant Cell Carcinoma

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Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 hepatocellular carcinoma 28.6 CDH1 CXCL8 IL6R MMP2 MYC
2 cryptogenic organizing pneumonia 10.2 CXCL8 TIMP1
3 pleural tuberculosis 10.2 CXCL8 TIMP1
4 bronchopulmonary dysplasia 10.2 CXCL8 TIMP1
5 crohn's colitis 10.1 CDH1 CXCL8
6 acute transverse myelitis 10.1 CXCL8 MMP2
7 transverse myelitis 10.1 CXCL8 MMP2
8 microcystic meningioma 10.1 MMP2 TIMP1
9 conjunctival nevus 10.1 MMP2 TIMP1
10 conjunctivochalasis 10.1 MMP2 TIMP1
11 lymphoepithelioma-like carcinoma 10.1 CDH1 KRT18
12 hypertrophic scars 10.1 MMP2 TIMP1
13 nasal cavity squamous cell carcinoma 10.1 MMP2 TIMP1
14 maxillary cancer 10.1 MMP2 TIMP1
15 septic arthritis 10.1 CXCL8 MMP2
16 interstitial cystitis 10.1 CDH1 CXCL8
17 sorsby fundus dystrophy 10.1 MMP2 TIMP1
18 appendicitis 10.1 CXCL8 TIMP1
19 tongue disease 10.1 CDH1 MMP2
20 joint disorders 10.1 IL6R TIMP1
21 bronchiolitis obliterans 10.0 CXCL8 TIMP1
22 ovarian cancer 1 10.0 CDH1 MMP2
23 lymphoma, large-cell, immunoblastic 10.0 MYC TIMP1
24 preterm premature rupture of the membranes 10.0 CXCL8 IL6R
25 malignant ovarian surface epithelial-stromal neoplasm 10.0 CDH1 MMP2
26 pulmonary fibrosis, idiopathic 10.0 CDH1 CXCL8 TIMP1
27 ovary epithelial cancer 10.0 CDH1 MMP2
28 chronic venous leg ulcers 10.0 MYC TIMP1
29 periodontitis 10.0 CXCL8 MMP2 TIMP1
30 periodontal disease 10.0 CXCL8 MMP2 TIMP1
31 cholecystitis 10.0 CDH1 KRT18
32 adenomyosis 10.0 CDH1 MMP2
33 female reproductive system disease 10.0 CDH1 CXCL8 MMP2
34 oral submucous fibrosis 10.0 CDH1 MMP2 TIMP1
35 laryngeal disease 10.0 CDH1 MMP2 NME1
36 gingival fibromatosis 9.9 MMP2 TIMP1
37 nasopharyngeal disease 9.9 CDH1 MYC
38 intussusception 9.9
39 pharynx cancer 9.9 CDH1 MYC
40 ovarian lymphoma 9.9 CXCL8 KRT18 MYC
41 cervix disease 9.9 CDH1 MYC
42 intestinal disease 9.9 CDH1 CXCL8 MYC
43 hepatitis 9.8
44 acquired immunodeficiency syndrome 9.8
45 respiratory system cancer 9.8 CDH1 MMP2 MYC
46 gastrointestinal system cancer 9.8 CDH1 MMP2 MYC
47 endocrine gland cancer 9.8 CDH1 MMP2 MYC
48 myeloma, multiple 9.8 CXCL8 IL6R MYC
49 adamantinoma of long bones 9.8 CDH1 MMP2 MYC
50 reproductive system disease 9.7 CDH1 CXCL8 MMP2 MYC

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to Lung Giant Cell Carcinoma
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Symptoms & Phenotypes for Lung Giant Cell Carcinoma

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UMLS symptoms related to Lung Giant Cell Carcinoma:


fever, dyspnea, hemoptysis, coughing

GenomeRNAi Phenotypes related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CDH1 CXCL8 IL6R KRT18 MMP2 MYC

MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 CDH1 GJA1 IL6R KRT18 MMP2 MYC
2 endocrine/exocrine gland MP:0005379 9.73 CDH1 GJA1 IL6R MYC NME1 TIMP1
3 mortality/aging MP:0010768 9.56 CDH1 GJA1 IL6R KRT18 MMP2 MYC
4 neoplasm MP:0002006 9.1 CDH1 IL6R MMP2 MYC NME1 TIMP1
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Drugs & Therapeutics for Lung Giant Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Lung Giant Cell Carcinoma

Cochrane evidence based reviews: carcinoma, giant cell

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Genetic Tests for Lung Giant Cell Carcinoma

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Anatomical Context for Lung Giant Cell Carcinoma

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MalaCards organs/tissues related to Lung Giant Cell Carcinoma:

41
Lung, Bone, Colon, Tongue, Ovary, Prostate, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Giant Cell Carcinoma:

19
Large Undifferentiated Cells
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Publications for Lung Giant Cell Carcinoma

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Articles related to Lung Giant Cell Carcinoma:

# Title Authors Year
1
Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma. ( 28159994 )
2017
2
Epidemiological features of lung giant cell carcinoma and therapy for patients with EGFR mutations based on case reports and the surveillance, epidemiology, and end results (SEER) database. ( 28445978 )
2017
3
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. ( 8017834 )
1994
4
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. ( 2200751 )
1990
5
Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. ( 2659722 )
1989
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Variations for Lung Giant Cell Carcinoma

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Cosmic variations for Lung Giant Cell Carcinoma:

9 (show top 50) (show all 550)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM905 RB1 lung,NS,carcinoma,giant cell carcinoma c.245C>A p.S82* 13:48307387-48307387 17
2 COSM516 KRAS lung,NS,carcinoma,giant cell carcinoma c.34G>T p.G12C 12:25245351-25245351 17
3 COSM6224 EGFR lung,NS,carcinoma,giant cell carcinoma c.2573T>G p.L858R 7:55191822-55191822 17
4 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 13
5 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 13
6 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 13
7 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 13
8 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 13
9 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 13
10 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 13
11 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 13
12 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 13
13 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 13
14 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 13
15 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 13
16 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 13
17 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 13
18 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 13
19 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 13
20 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 13
21 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 13
22 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 13
23 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 13
24 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 13
25 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 13
26 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 13
27 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 13
28 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 13
29 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 13
30 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 13
31 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 13
32 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 13
33 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 13
34 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 13
35 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 13
36 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 13
37 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 13
38 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 13
39 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 13
40 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 13
41 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 13
42 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 13
43 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 13
44 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 13
45 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 13
46 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 13
47 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 13
48 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 13
49 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 13
50 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 13
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Expression for Lung Giant Cell Carcinoma

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Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.
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Pathways for Lung Giant Cell Carcinoma

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Pathways related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.56 CDH1 CXCL8 IL6R KRT18 MYC TIMP1
2
TGF-Beta Pathway 64
Show member pathways
 13.26 CDH1 CXCL8 IL6R MYC TIMP1
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.06 CXCL8 IL6R MMP2 MYC TIMP1
4
Pathways in cancer 37
12.52 CDH1 CXCL8 IL6R MMP2 MYC
5
Development Slit-Robo signaling 22
Show member pathways
 12.28 CDH1 GJA1 KRT18
6
Cytoskeletal Signaling 4
12.27 CDH1 GJA1 KRT18
7
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.92 CXCL8 GJA1 IL6R
8
Colorectal Cancer Metastasis 64
11.89 CDH1 IL6R MMP2 MYC
9
Adhesion 4
11.79 CDH1 GJA1 MMP2
10
Spinal Cord Injury 1
11.77 CXCL8 GJA1 MYC
11
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.67 CDH1 CXCL8 IL6R MYC TIMP1
12
IL6-mediated signaling events 1
Show member pathways
 11.61 IL6R MYC TIMP1
13
Lung fibrosis 1
11.45 CXCL8 MMP2 TIMP1
14
Cell adhesion_ECM remodeling 22
11.42 CXCL8 MMP2 TIMP1
15
Wnt Signaling Pathway Netpath 1
11.35 GJA1 MYC
16
Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1
11.35 CDH1 CXCL8 MMP2 MYC
17
Hepatitis C and Hepatocellular Carcinoma 1
11.32 CXCL8 IL6R MYC
18
Interleukin-10 signaling 66
11.29 CXCL8 TIMP1
19
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.26 CXCL8 MYC
20
Arf6 trafficking events 1
11.23 CDH1 NME1
21
FOXM1 transcription factor network 1
11.14 MMP2 MYC
22
Bladder cancer 37 1
11.12 CDH1 CXCL8 MMP2 MYC
23
E-cadherin signaling in the nascent adherens junction 1
11.09 CDH1 NME1
24
Syndecan-2-mediated signaling events 1
11.08 CXCL8 MMP2
25
Interleukin-4 and 13 signaling 66
11.08 CXCL8 IL6R MMP2 MYC TIMP1
26
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.03 CXCL8 GJA1 MMP2
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GO Terms for Lung Giant Cell Carcinoma

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Cellular components related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 GJA1 KRT18 NME1

Biological processes related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.54 CDH1 MYC NME1
2 negative regulation of gene expression GO:0010629 9.43 GJA1 MYC NME1
3 extrinsic apoptotic signaling pathway GO:0097191 9.32 IL6R KRT18
4 cellular response to fibroblast growth factor stimulus GO:0044344 9.16 CXCL8 MYC
5 cytokine-mediated signaling pathway GO:0019221 9.02 CXCL8 IL6R MMP2 MYC TIMP1
6 positive regulation of DNA binding GO:0043388 8.96 MYC NME1

Molecular functions related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 CDH1 CXCL8 GJA1 IL6R KRT18 MMP2
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Sources for Lung Giant Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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