MCID: LNG017
MIFTS: 39

Lung Giant Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Giant Cell Carcinoma

MalaCards integrated aliases for Lung Giant Cell Carcinoma:

Name: Lung Giant Cell Carcinoma 12 15
Carcinoma, Giant Cell 44 73
Giant Cell Carcinoma of Lung 73
Giant Cell Lung Carcinoma 12
Giant Cell Carcinoma 12
Carcinoma Giant Cell 55

Classifications:



External Ids:

Disease Ontology 12 DOID:5583
MeSH 44 D018286
NCIt 50 C3779 C4452
SNOMED-CT 68 254631008 42596004

Summaries for Lung Giant Cell Carcinoma

Disease Ontology : 12 A lung carcinoma that is located in large undifferentiated cells.

MalaCards based summary : Lung Giant Cell Carcinoma, also known as carcinoma, giant cell, is related to pleural tuberculosis and lymphoma, large-cell, immunoblastic, and has symptoms including coughing, dyspnea and fever. An important gene associated with Lung Giant Cell Carcinoma is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include large undifferentiated cells and lung, and related phenotypes are Reduced mammosphere formation and growth/size/body region

Related Diseases for Lung Giant Cell Carcinoma

Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 pleural tuberculosis 10.5 CXCL8 TIMP1
2 lymphoma, large-cell, immunoblastic 10.5 MYC TIMP1
3 crohn's colitis 10.5 CDH1 CXCL8
4 bronchopulmonary dysplasia 10.4 CXCL8 TIMP1
5 conjunctivochalasis 10.4 MMP2 TIMP1
6 vibratory urticaria 10.3 CXCL8 MMP9
7 lymphoepithelioma-like carcinoma 10.3 CDH1 KRT18
8 autoimmune inner ear disease 10.3 MMP9 TIMP1
9 hypertrophic scars 10.3 MMP2 TIMP1
10 diabetic foot ulcers 10.3 MMP9 TIMP1
11 septic arthritis 10.3 CXCL8 MMP2
12 vulvar intraepithelial neoplasia 10.3 CDH1 MMP2
13 periodontosis 10.2 CXCL8 MMP9
14 mycetoma 10.2 CXCL8 MMP9
15 tuberculous meningitis 10.2 CXCL8 MMP9
16 extracranial arteriovenous malformation 10.1 MMP2 MMP9
17 focal myositis 10.1 MMP2 MMP9
18 chronic venous insufficiency 10.1 MMP9 TIMP1
19 spastic entropion 10.1 MMP2 MMP9
20 lentigo maligna melanoma 10.1 MMP2 MMP9
21 villous adenocarcinoma 10.1 MMP2 MMP9
22 central nervous system tuberculosis 10.1 MMP9 TIMP1
23 psammomatous meningioma 10.1 MMP2 MMP9
24 interstitial cystitis 10.1 CDH1 CXCL8
25 senile ectropion 10.1 MMP2 MMP9
26 internal hemorrhoid 10.1 MMP2 MMP9
27 venous insufficiency 10.1 MMP9 TIMP1
28 ischemic colitis 10.1 MMP2 MMP9
29 parotitis 10.1 MMP2 MMP9
30 light chain deposition disease 10.1 MMP2 MMP9
31 ovarian lymphoma 10.1 CXCL8 KRT18 MYC
32 opisthorchiasis 10.1 CXCL8 IL6R
33 klatskin's tumor 10.0 MMP2 MMP9
34 adenomyosis 10.0 MMP2 MMP9
35 corneal ulcer 10.0 MMP2 MMP9
36 cryptogenic organizing pneumonia 10.0 CXCL8 MMP9 TIMP1
37 preterm premature rupture of the membranes 10.0 CXCL8 IL6R
38 appendicitis 10.0 CXCL8 MMP9 TIMP1
39 odontogenic myxoma 10.0 MMP2 MMP9
40 bronchiolitis obliterans 10.0 CXCL8 MMP9 TIMP1
41 oral submucous fibrosis 10.0 CDH1 MMP2 TIMP1
42 interstitial lung disease 10.0 CXCL8 MMP9 TIMP1
43 pulmonary disease, chronic obstructive 9.9 CXCL8 MMP9 TIMP1
44 ovarian cancer 1 9.9 CDH1 MMP2 NME1
45 malignant ovarian surface epithelial-stromal neoplasm 9.9 CDH1 MMP2 NME1
46 ovary epithelial cancer 9.9 CDH1 MMP2 NME1
47 joint disorders 9.9 IL6R TIMP1
48 acute transverse myelitis 9.8 CXCL8 MMP2 MMP9
49 transverse myelitis 9.8 CXCL8 MMP2 MMP9
50 pharynx cancer 9.8 CDH1 MMP9

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to Lung Giant Cell Carcinoma

Symptoms & Phenotypes for Lung Giant Cell Carcinoma

UMLS symptoms related to Lung Giant Cell Carcinoma:


coughing, dyspnea, fever, hemoptysis

GenomeRNAi Phenotypes related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CDH1 CXCL8 IL6R KRT18 MMP2 MYC

MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 NME1 TIMP1 CDH1 IL6R KRT18 MMP2
2 mortality/aging MP:0010768 9.56 NME1 TIMP1 CDH1 IL6R KRT18 MMP2
3 neoplasm MP:0002006 9.17 TIMP1 CDH1 IL6R MMP2 MMP9 MYC

Drugs & Therapeutics for Lung Giant Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Giant Cell Carcinoma

Cochrane evidence based reviews: carcinoma, giant cell

Genetic Tests for Lung Giant Cell Carcinoma

Anatomical Context for Lung Giant Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Giant Cell Carcinoma:

19
Large Undifferentiated Cells

MalaCards organs/tissues related to Lung Giant Cell Carcinoma:

41
Lung

Publications for Lung Giant Cell Carcinoma

Articles related to Lung Giant Cell Carcinoma:

# Title Authors Year
1
Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma. ( 28159994 )
2017
2
Epidemiological features of lung giant cell carcinoma and therapy for patients with EGFR mutations based on case reports and the surveillance, epidemiology, and end results (SEER) database. ( 28445978 )
2017
3
[Study on differentially expressed molecules influencing the metastatic potential between highly and poorly metastatic human lung giant cell carcinoma]. ( 14690554 )
2003
4
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. ( 8017834 )
1994
5
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. ( 2200751 )
1990
6
Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. ( 2659722 )
1989

Variations for Lung Giant Cell Carcinoma

Cosmic variations for Lung Giant Cell Carcinoma:

9
(show top 50) (show all 550)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM905 RB1 lung,NS,carcinoma,giant cell carcinoma c.245C>A p.S82* 13:48307387-48307387 17
2 COSM516 KRAS lung,NS,carcinoma,giant cell carcinoma c.34G>T p.G12C 12:25245351-25245351 17
3 COSM6224 EGFR lung,NS,carcinoma,giant cell carcinoma c.2573T>G p.L858R 7:55191822-55191822 17
4 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 13
5 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 13
6 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 13
7 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 13
8 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 13
9 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 13
10 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 13
11 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 13
12 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 13
13 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 13
14 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 13
15 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 13
16 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 13
17 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 13
18 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 13
19 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 13
20 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 13
21 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 13
22 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 13
23 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 13
24 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 13
25 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 13
26 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 13
27 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 13
28 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 13
29 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 13
30 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 13
31 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 13
32 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 13
33 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 13
34 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 13
35 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 13
36 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 13
37 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 13
38 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 13
39 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 13
40 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 13
41 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 13
42 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 13
43 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 13
44 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 13
45 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 13
46 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 13
47 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 13
48 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 13
49 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 13
50 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 13

Expression for Lung Giant Cell Carcinoma

Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.

Pathways for Lung Giant Cell Carcinoma

Pathways related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CDH1 CXCL8 IL6R MMP2 MMP9 MYC
2
Show member pathways
13.1 CXCL8 IL6R MMP2 MMP9 MYC TIMP1
3 12.6 CDH1 CXCL8 IL6R MMP2 MMP9 MYC
4
Show member pathways
12.58 CDH1 IL6R MMP2 MMP9
5
Show member pathways
12.55 CDH1 MMP2 MMP9 TIMP1
6
Show member pathways
12.45 CXCL8 IL6R MYC
7
Show member pathways
12.34 CDH1 MMP2 MMP9 MYC
8
Show member pathways
12.15 CXCL8 IL6R MMP9
9 12.11 MMP2 MMP9 MYC
10 12.06 CXCL8 MMP9 MYC
11 11.87 CDH1 IL6R MMP2 MMP9 MYC
12 11.86 CDH1 MMP2 MMP9
13 11.84 CXCL8 MMP9 MYC
14
Show member pathways
11.84 CDH1 CXCL8 IL6R MYC TIMP1
15
Show member pathways
11.75 MMP2 MMP9 TIMP1
16 11.69 MMP2 MMP9 TIMP1
17
Show member pathways
11.66 IL6R MYC TIMP1
18 11.62 MMP9 MYC NME1
19 11.51 CXCL8 MMP2 MMP9
20
Show member pathways
11.47 CXCL8 MMP2 MMP9
21 11.47 CXCL8 MMP2 MMP9 TIMP1
22 11.45 CDH1 CXCL8 MMP2 MMP9 MYC
23 11.41 CXCL8 MMP2 MMP9 TIMP1
24 11.37 CXCL8 TIMP1
25 11.36 MMP2 MMP9
26 11.36 CXCL8 IL6R MYC
27 11.34 CDH1 MMP9
28 11.34 CXCL8 MYC
29
Show member pathways
11.32 MMP2 MMP9
30 11.31 CDH1 NME1
31 11.23 MMP2 MYC
32 11.22 CDH1 CXCL8 MMP2 MMP9 MYC
33 11.17 CDH1 NME1
34 11.17 CXCL8 MMP2
35 11.16 CXCL8 MMP2 MMP9
36 11.16 CXCL8 IL6R MMP2 MMP9 MYC TIMP1
37 11.15 MMP2 MMP9
38 11.04 MMP2 MMP9
39 11.02 MMP9 TIMP1
40 10.97 MMP2 MMP9

GO Terms for Lung Giant Cell Carcinoma

Cellular components related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.13 MMP2 MMP9 TIMP1
2 extracellular region GO:0005576 9.1 CDH1 CXCL8 IL6R MMP2 MMP9 TIMP1

Biological processes related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.56 KRT18 MMP9 MYC TIMP1
2 extrinsic apoptotic signaling pathway GO:0097191 9.48 IL6R KRT18
3 embryo implantation GO:0007566 9.46 MMP2 MMP9
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.43 MMP2 MMP9
5 cellular response to fibroblast growth factor stimulus GO:0044344 9.4 CXCL8 MYC
6 endodermal cell differentiation GO:0035987 9.37 MMP2 MMP9
7 positive regulation of DNA binding GO:0043388 9.33 MMP9 MYC NME1
8 positive regulation of leukocyte chemotaxis GO:0002690 9.32 CXCL8 IL6R
9 extracellular matrix disassembly GO:0022617 9.26 CDH1 MMP2 MMP9 TIMP1
10 cytokine-mediated signaling pathway GO:0019221 9.1 CXCL8 IL6R MMP2 MMP9 MYC TIMP1

Sources for Lung Giant Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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