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MCID: LNG035
MIFTS: 44

Lung Large Cell Carcinoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lung Large Cell Carcinoma

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MalaCards integrated aliases for Lung Large Cell Carcinoma:

Name: Lung Large Cell Carcinoma 12 15
Large Cell Carcinoma of Lung 12 74
Large Cell Lung Carcinoma 12 17
Large Cell Lung Cancer 56

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Respiratory diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4556
NCIt 51 C4450
UMLS 74 C0345958
Sources

Summaries for Lung Large Cell Carcinoma

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MalaCards based summary : Lung Large Cell Carcinoma, also known as large cell carcinoma of lung, is related to pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with rhabdoid phenotype. An important gene associated with Lung Large Cell Carcinoma is ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Development HGF signaling pathway and Integrated Breast Cancer Pathway. The drugs Carboplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and heart, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 77 Large-cell carcinoma (LCC) is a heterogeneous group of undifferentiated malignant neoplasms that lack... more...

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Related Diseases for Lung Large Cell Carcinoma

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Diseases in the Lung Large Cell Carcinoma family:

Small Cell Cancer of the Lung Lung Clear Cell Carcinoma

Diseases related to Lung Large Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 pulmonary large cell neuroendocrine carcinoma 31.9 ROS1 SYP
2 large cell carcinoma with rhabdoid phenotype 11.9
3 lung cancer 11.6
4 lung mixed small cell and squamous cell carcinoma 11.4
5 large cell neuroendocrine carcinoma 11.1
6 large cell carcinoma 10.4
7 subependymal glioma 10.1 MTOR SYP
8 atrial septal defect 4 10.1 ABL1 MTOR
9 benign ependymoma 10.1 MTOR SYP
10 subependymal giant cell astrocytoma 10.0 MTOR SYP
11 central nervous system benign neoplasm 10.0 MTOR SYP
12 thymus gland disease 10.0 MTOR TTN
13 thrombocytosis 9.8
14 aland island eye disease 9.8
15 reflex sympathetic dystrophy 9.8
16 dermatomyositis 9.8
17 algoneurodystrophy 9.8
18 neuroendocrine carcinoma 9.8
19 calcinosis 9.8
20 inner ear disease 9.8
21 adenocarcinoma 9.8
22 vasculitis 9.8
23 polyarteritis nodosa 9.8
24 autoimmune inner ear disease 9.8
25 pulmonary sequestration 9.8
26 myxosarcoma 9.8 NME1 SYP
27 geographic tongue 9.7 MTOR NME1
28 malignant pheochromocytoma 9.7 NME1 SYP

Graphical network of the top 20 diseases related to Lung Large Cell Carcinoma:



Diseases related to Lung Large Cell Carcinoma
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Symptoms & Phenotypes for Lung Large Cell Carcinoma

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GenomeRNAi Phenotypes related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

27 (show top 50) (show all 53)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 11.24 MTOR
2 Decreased viability GR00221-A-1 11.24 ABL1 MTOR RPS6KA6 ROS1 NME1 CAMK4
3 Decreased viability GR00221-A-2 11.24 ABL1 RPS6KA6 EPHA5 TTN ROS1 NME1
4 Decreased viability GR00221-A-3 11.24 ABL1 CDC42BPB EPHA5
5 Decreased viability GR00221-A-4 11.24 MTOR RPS6KA6 CDC42BPB EPHA5 TTN
6 Decreased viability GR00301-A 11.24 CAMK4
7 Decreased viability GR00342-S-1 11.24 ABL1 MTOR TTN ROS1
8 Decreased viability GR00342-S-2 11.24 ABL1 MTOR RPS6KA6
9 Decreased viability GR00342-S-3 11.24 ABL1 RPS6KA6 EPHA5 TTN
10 Decreased viability GR00402-S-2 11.24 ABL1 MTOR RPS6KA6 CDC42BPB EPHA5 TTN
11 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.48 ABL1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.48 ABL1 MTOR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.48 MTOR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.48 ATR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.48 TRRAP
16 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.48 NME1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.48 CAMK4
18 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.48 ABL1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.48 NME1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.48 ABL1 CAMK4
21 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.48 ABL1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.48 MTOR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.48 ATR
24 Increased shRNA abundance (Z-score > 2) GR00366-A-172 10.48 NME1 TRRAP
25 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.48 TRRAP
26 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.48 TRRAP
27 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.48 CAMK4
28 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.48 ATR
29 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.48 ATR
30 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.48 ABL1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.48 ABL1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.48 MTOR
33 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.48 ABL1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.48 ABL1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.48 NME1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.48 ABL1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.48 CAMK4
38 Increased shRNA abundance (Z-score > 2) GR00366-A-69 10.48 CAMK4
39 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.48 ATR
40 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.48 CAMK4 MTOR
41 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.48 ABL1
42 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.48 ABL1 ATR CAMK4 MTOR NME1 TRRAP
43 Increased shRNA abundance (Z-score > 2) GR00366-A-97 10.48 NME1
44 Decreased substrate adherent cell growth GR00193-A-1 10.17 ATR ROS1 TTN
45 Decreased substrate adherent cell growth GR00193-A-2 10.17 ROS1 ABL1 MTOR NEK1 TRRAP
46 Decreased substrate adherent cell growth GR00193-A-4 10.17 ABL1
47 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 10.16 ABL1 ATR CAMK4 CDC42BPB MTOR NEK1
48 Decreased vesicular stomatitis virus (VSV) infection GR00356-A-1 9.8 ATR CAMK4 MTOR TRRAP TTN
49 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.78 ABL1 ATR MTOR TRRAP
50 Increased colony dispersion (increased number of colonies and decreased number of cells per colony) GR00212-A 9.56 ATR MTOR ROS1 TRRAP

MGI Mouse Phenotypes related to Lung Large Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.23 ABL1 ATR CAMK4 EPHA5 MTOR NEK1
Sources

Drugs & Therapeutics for Lung Large Cell Carcinoma

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Drugs for Lung Large Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 136)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
2
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
3
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 5284616 6436030
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
6 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1
7 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Albumin-Bound Paclitaxel Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
13 Antifungal Agents Phase 4
14 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
15
Gefitinib Approved, Investigational Phase 3,Phase 2,Phase 1 184475-35-2 123631
16
Etoposide Approved Phase 3,Phase 1,Phase 2 33419-42-0 36462
17
Docetaxel Approved, Investigational Phase 3,Phase 2,Phase 1 114977-28-5 148124
18
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
19
Vinorelbine Approved, Investigational Phase 3,Phase 2,Phase 1 71486-22-1 44424639 60780
20
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
21
Pemetrexed Approved, Investigational Phase 3,Phase 2,Phase 1 150399-23-8, 137281-23-3 60843 446556
22
leucovorin Approved Phase 3,Phase 2,Phase 1 58-05-9 143 6006
23
Bevacizumab Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 216974-75-3
24
Vindesine Approved, Investigational Phase 3 53643-48-4, 59917-39-4 40839
25
Vinblastine Approved Phase 3 865-21-4 241903 13342
26
Cetuximab Approved Phase 3,Phase 2,Phase 1 205923-56-4 56842117 2333
27
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
28
Celecoxib Approved, Investigational Phase 3,Phase 2 169590-42-5 2662
29
nivolumab Approved Phase 3,Phase 2 946414-94-4
30
Crizotinib Approved Phase 3,Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
31
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
33
Tyrosine Approved, Investigational, Nutraceutical Phase 3,Phase 2,Phase 1 60-18-4 6057
34
Tirapazamine Investigational Phase 3,Phase 1 27314-97-2
35
Erlotinib Hydrochloride Phase 3,Phase 2,Phase 1 183319-69-9 176871
36 Protein Kinase Inhibitors Phase 3,Phase 2,Phase 1
37 Immunoglobulins Phase 2, Phase 3,Phase 3,Phase 1
38 Antibodies, Monoclonal Phase 2, Phase 3,Phase 3,Phase 1
39 Antibodies Phase 2, Phase 3,Phase 3,Phase 1
40 Antineoplastic Agents, Immunological Phase 2, Phase 3,Phase 3,Phase 1
41 Topoisomerase Inhibitors Phase 3,Phase 1,Phase 2
42 Etoposide phosphate Phase 3,Phase 1,Phase 2
43 Antiviral Agents Phase 3,Phase 2,Phase 1
44 Antimetabolites Phase 3,Phase 2,Phase 1
45 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
46 Hematinics Phase 3,Phase 2
47 Folate Phase 3,Phase 2,Phase 1
48 Vitamin B Complex Phase 3,Phase 2,Phase 1
49 Folic Acid Antagonists Phase 3,Phase 2,Phase 1
50 Vitamin B9 Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 152)
# Name Status NCT ID Phase Drugs
1 RAD001 With Paclitaxel and Carboplatin in First Line Treatment of Patients With Advanced Large Cell Lung Cancer With Neuroendocrine Differentiation Completed NCT01317615 Phase 4 RAD001;Paclitaxel;Carboplatin
2 Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly Completed NCT02151149 Phase 4 nab-paclitaxel;Carboplatin
3 Radiation Therapy to the Brain or Observation in Preventing Brain Metastases in Patients With Advanced Non-Small Cell Lung Cancer Unknown status NCT00955695 Phase 3 erlotinib hydrochloride;gefitinib
4 Carboplatin, Paclitaxel, and Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed During Surgery Completed NCT00003387 Phase 3 carboplatin;chemotherapy;paclitaxel
5 Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Advanced, Metastatic, or Recurrent Non-Small Cell Lung Cancer Completed NCT00021060 Phase 2, Phase 3 paclitaxel;carboplatin
6 Combination Chemotherapy and Radiation Therapy With or Without Gefitinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery Completed NCT00020709 Phase 3 cisplatin;docetaxel;etoposide;gefitinib
7 Combination Chemotherapy Plus Radiation Therapy With or Without AE-941 in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed By Surgery Completed NCT00005838 Phase 3 shark cartilage extract AE-941;cisplatin;vinorelbine tartrate;carboplatin;paclitaxel
8 Surgery With or Without Chemotherapy in Treating Patients With Stage I Non-small Cell Lung Cancer Completed NCT00002852 Phase 3 paclitaxel;carboplatin
9 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer That Can Not Be Surgically Removed Completed NCT00003235 Phase 3 carboplatin;paclitaxel
10 Chemotherapy Plus Radiation Therapy With or Without Surgery in Treating Patients With Stage IIIA Non-small Cell Lung Cancer Completed NCT00002550 Phase 3 cisplatin;etoposide
11 Lymph Node Removal in Treating Patients With Stage I or Stage II Non-small Cell Lung Cancer Completed NCT00003831 Phase 3
12 Gefitinib in Treating Patients With Stage IB, II, or IIIA Non-small Cell Lung Cancer That Was Completely Removed by Surgery Completed NCT00049543 Phase 3 gefitinib
13 Vinorelbine, Gemcitabine, and Docetaxel Compared With Paclitaxel and Carboplatin in Treating Patients With Advanced Non-Small Cell Lung Cancer Completed NCT00079287 Phase 3 carboplatin;docetaxel;gemcitabine hydrochloride;paclitaxel;vinorelbine tartrate
14 Chemotherapy and Radiation Therapy With or Without Epoetin Alfa in Treating Patients With Stage IIIA or Stage IIIB Non-Small Cell Lung Cancer Completed NCT00028938 Phase 3 carboplatin;paclitaxel
15 Chemotherapy Followed by Surgery or Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer Completed NCT00002623 Phase 3 carboplatin;cisplatin
16 Combination Chemotherapy With or Without Tirapazamine in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer Completed NCT00006484 Phase 3 carboplatin;paclitaxel;tirapazamine
17 Prognostic Study of Metastases in Patients With Stage I, Stage II, or Stage III Non-small Cell Lung Cancer That Can Be Removed by Surgery Completed NCT00003901 Phase 3
18 Paclitaxel With or Without Carboplatin in Treating Patients With Advanced Non-small Cell Lung Cancer Completed NCT00003117 Phase 3 carboplatin;paclitaxel
19 Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer Completed NCT00003685 Phase 3
20 Combination Chemotherapy Compared With No Treatment Following Surgery in Treating Patients With Non-small Cell Lung Cancer Completed NCT00002823 Phase 3 cisplatin;etoposide;vinblastine sulfate;vindesine;vinorelbine tartrate
21 Genetic Testing in Screening Patients With Stage IB-IIIA Non-Small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial) Recruiting NCT02194738 Phase 3 Crizotinib;Erlotinib Hydrochloride
22 Preoperative Chemoradiotherapy vs. Chemotherapy Alone in NSCLC Patients Active, not recruiting NCT00030771 Phase 3 Chemotherapy
23 S0819: Carboplatin and Paclitaxel With or Without Bevacizumab and/or Cetuximab in Treating Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer Active, not recruiting NCT00946712 Phase 3 Carboplatin;Paclitaxel
24 Comparison of Different Types of Surgery in Treating Patients With Stage IA Non-Small Cell Lung Cancer Active, not recruiting NCT00499330 Phase 3
25 Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer Active, not recruiting NCT01107626 Phase 3 pemetrexed disodium
26 Cisplatin and Docetaxel With or Without Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Newly Diagnosed Stage III Non-Small Cell Lung Cancer Terminated NCT00113386 Phase 3 cisplatin;docetaxel
27 Gemcitabine Hydrochloride or Pemetrexed Disodium and Carboplatin With or Without Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer Terminated NCT01041781 Phase 3 carboplatin;celecoxib;gemcitabine hydrochloride;pemetrexed disodium
28 Carboplatin, Paclitaxel, and Radiation Therapy With or Without Thalidomide in Patients With Stage III Non-small Cell Lung Cancer Terminated NCT00004859 Phase 3 carboplatin;paclitaxel;thalidomide
29 Pazopanib Hydrochloride or a Placebo in Treating Patients With Non-Small Cell Lung Cancer Who Have Received First-Line Chemotherapy Terminated NCT01208064 Phase 2, Phase 3 pazopanib hydrochloride
30 Chemotherapy or Observation in Treating Patients With Early Stage Non-Small Cell Lung Cancer Terminated NCT00863512 Phase 3 cisplatin;docetaxel;gemcitabine hydrochloride;pemetrexed disodium;vinorelbine tartrate
31 Chemotherapy and Radiation Therapy With or Without Efaproxiral in Treating Patients With Stage III Non-Small Cell Lung Cancer Withdrawn NCT00055887 Phase 3 carboplatin;cisplatin;efaproxiral;gemcitabine hydrochloride;paclitaxel;vinorelbine ditartrate
32 Combination Chemotherapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer Withdrawn NCT00054392 Phase 3 carboplatin;gemcitabine hydrochloride;paclitaxel
33 Gefitinib in Treating Patients With Stage IIIA Non-Small Cell Lung Cancer Unknown status NCT00616499 Phase 2 gefitinib
34 Docetaxel Plus Carboplatin in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer Unknown status NCT00003562 Phase 2 carboplatin;docetaxel
35 Gemcitabine and Docetaxel in Treating Patients With Inoperable Stage IIIB or Stage IV Non-Small Cell Lung Cancer Unknown status NCT00075517 Phase 2 docetaxel;gemcitabine hydrochloride
36 Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer Unknown status NCT00006116 Phase 2 cisplatin;gemcitabine hydrochloride
37 Paclitaxel, Carboplatin, and Gefitinib in Treating Patients With Advanced Non-Small Cell Lung Cancer Unknown status NCT01024712 Phase 2 carboplatin;gefitinib;paclitaxel
38 Docetaxel in Treating Older Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Unknown status NCT00227708 Phase 2 docetaxel
39 Lometrexol Plus Folic Acid in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer Unknown status NCT00033722 Phase 2 lometrexol
40 Gemcitabine and Cisplatin Before or After Surgery in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer Unknown status NCT00398385 Phase 2 cisplatin;gemcitabine hydrochloride
41 Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer Completed NCT01642251 Phase 1, Phase 2 Cisplatin;Etoposide;Veliparib;Placebo
42 Combination Chemotherapy Followed by Surgery in Treating Patients With Non-small Cell Lung Cancer Completed NCT00003231 Phase 2 cisplatin;docetaxel
43 Combination Chemotherapy Followed by Radiation Therapy Before Surgery in Treating Patients With Stage IIIB NSCLC Completed NCT00030810 Phase 2 Taxotere/Cisplatin
44 Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Completed NCT00960999 Phase 2
45 MK2206 and Erlotinib Hydrochloride in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Progressed After Previous Response to Erlotinib Hydrochloride Therapy Completed NCT01294306 Phase 2 Akt Inhibitor MK2206;Erlotinib Hydrochloride
46 S0341: Erlotinib in Treating Patients With Advanced Primary Non-Small Cell Lung Cancer Completed NCT00087412 Phase 2 erlotinib hydrochloride
47 Bevacizumab, Pemetrexed Disodium, and Cisplatin or Erlotinib Hydrochloride and Bevacizumab in Treating Patients With Stage IV Non-Small Cell Lung Cancer. A Multicenter Phase II Trial Including Biopsy at Progression (BIO-PRO Trial). Completed NCT01116219 Phase 2 bevacizumab, pemetrexed, cisplatin
48 Irofulven in Treating Patients With Relapsed or Refractory Non-small Cell Lung Cancer Completed NCT00003666 Phase 2 6-hydroxymethylacylfulvene
49 Temozolomide in Treating Patients With Metastatic Non-small Cell Lung Cancer Completed NCT00006877 Phase 2 temozolomide
50 Video-Assisted Surgery Followed by Radiation Therapy in Treating Patients With Stage I Non-small Cell Lung Cancer and Poor Heart and Lung Function Completed NCT00002624 Phase 2

Search NIH Clinical Center for Lung Large Cell Carcinoma

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Genetic Tests for Lung Large Cell Carcinoma

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Anatomical Context for Lung Large Cell Carcinoma

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MalaCards organs/tissues related to Lung Large Cell Carcinoma:

42
Lung, Brain, Heart, Testes, Lymph Node, Endothelial, Eye
Sources

Publications for Lung Large Cell Carcinoma

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Articles related to Lung Large Cell Carcinoma:

(show all 13)
# Title Authors Year
1
The landscape of actionable molecular alterations in immunomarker-defined large cell carcinoma of lung. ( 30978501 )
2019
2
Oxidative stress associates with aggressiveness in lung large-cell carcinoma. ( 25638031 )
2015
3
Large cell carcinoma of lung: On the verge of extinction? ( 25023633 )
2014
4
Rhabdoid large cell carcinoma of lung, with illustrative immunohistochemical and molecular findings. ( 22505007 )
2012
5
Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model. ( 20077433 )
2010
6
Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. ( 20123594 )
2010
7
Lung large cell carcinoma producing granulocyte-colony-stimulating factor. ( 17184692 )
2007
8
Bilateral adrenal metastases from large cell carcinoma of lung in a female non-smoker patient. ( 16912999 )
2006
9
Primary lung large cell carcinoma metastatic to the vulva: a case report and review of the literature. ( 15350382 )
2004
10
Solitary adrenal metastasis in large cell carcinoma of lung. ( 15558361 )
2004
11
Large cell carcinoma of lung with osteoclast-like giant cells. ( 9639130 )
1998
12
High-dose tamoxifen reverses drug resistance to cisplatin and etoposide in a patient with advanced large cell carcinoma of lung. ( 9137495 )
1997
13
Establishment and characterization of a cell line, KaMi, from human lung large cell carcinoma. ( 1279943 )
1992
Sources

Variations for Lung Large Cell Carcinoma

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Cosmic variations for Lung Large Cell Carcinoma:

9 (show top 50) (show all 732)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 0
2 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 0
3 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 0
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 0
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 0
6 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 0
7 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 0
8 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 0
9 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 0
10 COSM21262 WNK3 lung,NS,carcinoma,large cell carcinoma c.4599G>T p.L1533F 23:54236967-54236967 0
11 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 0
12 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 0
13 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 0
14 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 0
15 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 0
16 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 0
17 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 0
18 COSM12945 TTBK1 lung,NS,carcinoma,large cell carcinoma c.2417C>T p.S806F 6:43283157-43283157 0
19 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 0
20 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 0
21 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 0
22 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 0
23 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 0
24 COSM12943 TRRAP lung,NS,carcinoma,large cell carcinoma c.8015C>T p.P2672L 7:98976613-98976613 0
25 COSM12942 TRPM6 lung,NS,carcinoma,large cell carcinoma c.3021G>C p.W1007C 9:74782752-74782752 0
26 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 0
27 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 0
28 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 0
29 COSM10808 TP53 lung,NS,carcinoma,large cell carcinoma c.488A>G p.Y163C 17:7675124-7675124 0
30 COSM10659 TP53 lung,NS,carcinoma,large cell carcinoma c.817C>T p.R273C 17:7673803-7673803 0
31 COSM10887 TP53 lung,NS,carcinoma,large cell carcinoma c.833C>G p.P278R 17:7673787-7673787 0
32 COSM11188 TP53 lung,NS,carcinoma,large cell carcinoma c.412G>C p.A138P 17:7675200-7675200 0
33 COSM21593 TP53 lung,NS,carcinoma,large cell carcinoma c.358A>T p.K120* 17:7676011-7676011 0
34 COSM10779 TP53 lung,NS,carcinoma,large cell carcinoma c.818G>T p.R273L 17:7673802-7673802 0
35 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 0
36 COSM10770 TP53 lung,NS,carcinoma,large cell carcinoma c.1045G>T p.E349* 17:7670664-7670664 0
37 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 0
38 COSM11333 TP53 lung,NS,carcinoma,large cell carcinoma c.499C>T p.Q167* 17:7675113-7675113 0
39 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 0
40 COSM10726 TP53 lung,NS,carcinoma,large cell carcinoma c.856G>A p.E286K 17:7673764-7673764 0
41 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 0
42 COSM11196 TP53 lung,NS,carcinoma,large cell carcinoma c.734G>T p.G245V 17:7674229-7674229 0
43 COSM11564 TP53 lung,NS,carcinoma,large cell carcinoma c.742C>G p.R248G 17:7674221-7674221 0
44 COSM10810 TP53 lung,NS,carcinoma,large cell carcinoma c.725G>T p.C242F 17:7674238-7674238 0
45 COSM11392 TP53 lung,NS,carcinoma,large cell carcinoma c.800G>C p.R267P 17:7673820-7673820 0
46 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 0
47 COSM11073 TP53 lung,NS,carcinoma,large cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 0
48 COSM43559 TP53 lung,NS,carcinoma,large cell carcinoma c.517G>T p.V173L 17:7675095-7675095 0
49 COSM43896 TP53 lung,NS,carcinoma,large cell carcinoma c.818G>C p.R273P 17:7673802-7673802 0
50 COSM44398 TP53 lung,NS,carcinoma,large cell carcinoma c.682G>A p.D228N 17:7674281-7674281 0
Sources

Expression for Lung Large Cell Carcinoma

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Search GEO for disease gene expression data for Lung Large Cell Carcinoma.
Sources

Pathways for Lung Large Cell Carcinoma

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Pathways related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development HGF signaling pathway 23
Show member pathways
 11.89 ABL1 CAMK4 MTOR RPS6KA6
2
Integrated Breast Cancer Pathway 1
11.62 ABL1 ATR MTOR
3
Tyrosine Kinases / Adaptors 4
11.5 ABL1 EPHA5 ROS1
4
UVA-Induced MAPK Signaling 65
Show member pathways
 10.9 ABL1 MTOR RPS6KA6
Sources

GO Terms for Lung Large Cell Carcinoma

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Cellular components related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.28 ABL1 CAMK4 CDC42BPB MTOR MYO18B NEK1

Biological processes related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 endocytosis GO:0006897 9.67 ABL1 NME1 SYP
2 protein autophosphorylation GO:0046777 9.61 ABL1 ATR MTOR
3 protein phosphorylation GO:0006468 9.61 ABL1 CAMK4 CDC42BPB EPHA5 MTOR NEK1
4 peptidyl-serine phosphorylation GO:0018105 9.58 ATR CAMK4 MTOR
5 peptidyl-tyrosine phosphorylation GO:0018108 9.55 ABL1 EPHA5 NEK1 ROS1 TTN
6 positive regulation of neuron death GO:1901216 9.54 ABL1 MTOR
7 long-term memory GO:0007616 9.52 CAMK4 MTOR
8 peptidyl-tyrosine autophosphorylation GO:0038083 9.51 ABL1 ROS1
9 regulation of protein kinase activity GO:0045859 9.48 MTOR TTN
10 positive regulation of protein phosphorylation GO:0001934 9.46 ABL1 MTOR
11 regulation of actin cytoskeleton organization GO:0032956 9.43 ABL1 EPHA5 MTOR
12 phosphorylation GO:0016310 9.4 ABL1 ATR CAMK4 CDC42BPB EPHA5 MTOR
13 cardiac muscle fiber development GO:0048739 9.37 MYO18B TTN
14 regulation of osteoclast differentiation GO:0045670 9.32 CAMK4 MTOR

Molecular functions related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.93 ABL1 ATR CAMK4 CDC42BPB EPHA5 MTOR
2 protein serine/threonine kinase activity GO:0004674 9.87 ATR CAMK4 CDC42BPB MTOR NEK1 RPS6KA6
3 protein tyrosine kinase activity GO:0004713 9.77 ABL1 EPHA5 NEK1 ROS1 TTN
4 magnesium ion binding GO:0000287 9.71 ABL1 CDC42BPB NME1 RPS6KA6
5 protein kinase activity GO:0004672 9.65 ABL1 ATR CAMK4 CDC42BPB EPHA5 MTOR
6 SH2 domain binding GO:0042169 9.43 ABL1 SYP
7 kinase activity GO:0016301 9.4 ABL1 ATR CAMK4 CDC42BPB EPHA5 MTOR
8 transferase activity GO:0016740 10.03 ABL1 ATR CAMK4 CDC42BPB EPHA5 MTOR
Sources

Sources for Lung Large Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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