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MCID: LNG035
MIFTS: 40

Lung Large Cell Carcinoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Lung Large Cell Carcinoma

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MalaCards integrated aliases for Lung Large Cell Carcinoma:

Name: Lung Large Cell Carcinoma 12 15
Large Cell Carcinoma of Lung 12 73
Large Cell Lung Carcinoma 12
Large Cell Lung Cancer 55

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Respiratory diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4556
NCIt 50 C4450
UMLS 73 C0345958
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Summaries for Lung Large Cell Carcinoma

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MalaCards based summary : Lung Large Cell Carcinoma, also known as large cell carcinoma of lung, is related to large cell carcinoma with rhabdoid phenotype and lung cancer. An important gene associated with Lung Large Cell Carcinoma is ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Development HGF signaling pathway and G-protein signaling RAC1 in cellular process. Affiliated tissues include lung, endothelial and tongue, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Large-cell carcinoma (LCC) is a heterogeneous group of undifferentiated malignant neoplasms that lack... more...

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Related Diseases for Lung Large Cell Carcinoma

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Diseases in the Lung Large Cell Carcinoma family:

Small Cell Cancer of the Lung Lung Clear Cell Carcinoma

Diseases related to Lung Large Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 large cell carcinoma with rhabdoid phenotype 11.9
2 lung cancer 11.6
3 lung mixed small cell and squamous cell carcinoma 11.3
4 pulmonary large cell neuroendocrine carcinoma 11.1
5 large cell carcinoma 10.4
6 thymus gland disease 10.0 MTOR TTN
7 geographic tongue 9.9 MTOR NME1
8 thrombocytosis 9.8
9 reflex sympathetic dystrophy 9.8
10 polyarteritis nodosa, childhood-onset 9.8
11 large cell neuroendocrine carcinoma 9.8
12 dermatomyositis 9.8
13 algoneurodystrophy 9.8
14 calcinosis 9.8
15 inner ear disease 9.8
16 vasculitis 9.8
17 polyarteritis nodosa 9.8
18 autoimmune inner ear disease 9.8
19 pulmonary sequestration 9.8

Graphical network of the top 20 diseases related to Lung Large Cell Carcinoma:



Diseases related to Lung Large Cell Carcinoma
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Symptoms & Phenotypes for Lung Large Cell Carcinoma

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GenomeRNAi Phenotypes related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show top 50) (show all 65)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 11.11 MTOR
2 Decreased viability GR00221-A-1 11.11 MTOR ROS1 RPS6KA6 CAMK4 NME1
3 Decreased viability GR00221-A-2 11.11 ROS1 TTN EPHA5 RPS6KA6 NME1 NTRK3
4 Decreased viability GR00221-A-3 11.11 EPHA5 CDC42BPB TRIB1
5 Decreased viability GR00221-A-4 11.11 MTOR TTN EPHA5 RPS6KA6 CDC42BPB NTRK3
6 Decreased viability GR00301-A 11.11 CAMK4
7 Decreased viability GR00342-S-1 11.11 MTOR ROS1 TTN
8 Decreased viability GR00342-S-2 11.11 MTOR RPS6KA6 CASK
9 Decreased viability GR00342-S-3 11.11 TTN EPHA5 RPS6KA6
10 Decreased viability GR00402-S-2 11.11 MTOR ROS1 TTN EPHA5 RPS6KA6 CASK
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 10.47 NTRK3
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 10.47 TRRAP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 10.47 NTRK3
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 10.47 CASK
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.47 TRRAP
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.47 MTOR
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 10.47 NTRK3
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.47 TRRAP
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 10.47 CASK
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 10.47 TRRAP
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.47 MTOR
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 10.47 NTRK3
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.47 CASK MTOR NTRK3 TRRAP
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 10.47 CASK
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 10.47 TRRAP
26 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 10.47 CASK
27 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.47 CASK TRRAP
28 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.47 CASK
29 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.41 CASK
30 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.41 MTOR
31 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.41 MTOR
32 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.41 CASK
33 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.41 NME1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.41 CAMK4
35 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.41 NME1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.41 NTRK3
37 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.41 NTRK3
38 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.41 CASK
39 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.41 CAMK4
40 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.41 NTRK3
41 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.41 MTOR
42 Increased shRNA abundance (Z-score > 2) GR00366-A-172 10.41 NME1 TRRAP
43 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.41 CASK
44 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.41 CASK
45 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.41 TRRAP
46 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.41 TRRAP
47 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.41 CAMK4
48 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.41 NTRK3
49 Increased shRNA abundance (Z-score > 2) GR00366-A-41 10.41 NTRK3
50 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.41 MTOR NTRK3

MGI Mouse Phenotypes related to Lung Large Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.61 CAMK4 CASK MTOR NEK1 NME1 NTRK3
2 mortality/aging MP:0010768 9.32 CAMK4 CASK MTOR MYO18B NEK1 NME1
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Drugs & Therapeutics for Lung Large Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Lung Large Cell Carcinoma

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Genetic Tests for Lung Large Cell Carcinoma

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Anatomical Context for Lung Large Cell Carcinoma

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MalaCards organs/tissues related to Lung Large Cell Carcinoma:

41
Lung, Endothelial, Tongue, Thymus
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Publications for Lung Large Cell Carcinoma

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Articles related to Lung Large Cell Carcinoma:

(show all 12)
# Title Authors Year
1
Oxidative stress associates with aggressiveness in lung large-cell carcinoma. ( 25638031 )
2015
2
Large cell carcinoma of lung: On the verge of extinction? ( 25023633 )
2014
3
Rhabdoid large cell carcinoma of lung, with illustrative immunohistochemical and molecular findings. ( 22505007 )
2012
4
Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. ( 20123594 )
2010
5
Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model. ( 20077433 )
2010
6
Lung large cell carcinoma producing granulocyte-colony-stimulating factor. ( 17184692 )
2007
7
Bilateral adrenal metastases from large cell carcinoma of lung in a female non-smoker patient. ( 16912999 )
2006
8
Solitary adrenal metastasis in large cell carcinoma of lung. ( 15558361 )
2004
9
Primary lung large cell carcinoma metastatic to the vulva: a case report and review of the literature. ( 15350382 )
2004
10
Large cell carcinoma of lung with osteoclast-like giant cells. ( 9639130 )
1998
11
High-dose tamoxifen reverses drug resistance to cisplatin and etoposide in a patient with advanced large cell carcinoma of lung. ( 9137495 )
1997
12
Establishment and characterization of a cell line, KaMi, from human lung large cell carcinoma. ( 1279943 )
1992
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Variations for Lung Large Cell Carcinoma

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Cosmic variations for Lung Large Cell Carcinoma:

9 (show top 50) (show all 732)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM21262 WNK3 lung,NS,carcinoma,large cell carcinoma c.4599G>T p.L1533F 23:54236967-54236967 15
2 COSM12945 TTBK1 lung,NS,carcinoma,large cell carcinoma c.2417C>T p.S806F 6:43283157-43283157 15
3 COSM12943 TRRAP lung,NS,carcinoma,large cell carcinoma c.8015C>T p.P2672L 7:98976613-98976613 15
4 COSM12942 TRPM6 lung,NS,carcinoma,large cell carcinoma c.3021G>C p.W1007C 9:74782752-74782752 15
5 COSM10808 TP53 lung,NS,carcinoma,large cell carcinoma c.488A>G p.Y163C 17:7675124-7675124 15
6 COSM43963 TP53 lung,NS,carcinoma,large cell carcinoma c.396G>C p.K132N 17:7675216-7675216 15
7 COSM11188 TP53 lung,NS,carcinoma,large cell carcinoma c.412G>C p.A138P 17:7675200-7675200 15
8 COSM10887 TP53 lung,NS,carcinoma,large cell carcinoma c.833C>G p.P278R 17:7673787-7673787 15
9 COSM21593 TP53 lung,NS,carcinoma,large cell carcinoma c.358A>T p.K120* 17:7676011-7676011 15
10 COSM10779 TP53 lung,NS,carcinoma,large cell carcinoma c.818G>T p.R273L 17:7673802-7673802 15
11 COSM10770 TP53 lung,NS,carcinoma,large cell carcinoma c.1045G>T p.E349* 17:7670664-7670664 15
12 COSM11333 TP53 lung,NS,carcinoma,large cell carcinoma c.499C>T p.Q167* 17:7675113-7675113 15
13 COSM43871 TP53 lung,NS,carcinoma,large cell carcinoma c.746G>T p.R249M 17:7674217-7674217 15
14 COSM10726 TP53 lung,NS,carcinoma,large cell carcinoma c.856G>A p.E286K 17:7673764-7673764 15
15 COSM11564 TP53 lung,NS,carcinoma,large cell carcinoma c.742C>G p.R248G 17:7674221-7674221 15
16 COSM10659 TP53 lung,NS,carcinoma,large cell carcinoma c.817C>T p.R273C 17:7673803-7673803 15
17 COSM11196 TP53 lung,NS,carcinoma,large cell carcinoma c.734G>T p.G245V 17:7674229-7674229 15
18 COSM11392 TP53 lung,NS,carcinoma,large cell carcinoma c.800G>C p.R267P 17:7673820-7673820 15
19 COSM10810 TP53 lung,NS,carcinoma,large cell carcinoma c.725G>T p.C242F 17:7674238-7674238 15
20 COSM10648 TP53 lung,NS,carcinoma,large cell carcinoma c.524G>A p.R175H 17:7675088-7675088 15
21 COSM11073 TP53 lung,NS,carcinoma,large cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 15
22 COSM43559 TP53 lung,NS,carcinoma,large cell carcinoma c.517G>T p.V173L 17:7675095-7675095 15
23 COSM44398 TP53 lung,NS,carcinoma,large cell carcinoma c.682G>A p.D228N 17:7674281-7674281 15
24 COSM43896 TP53 lung,NS,carcinoma,large cell carcinoma c.818G>C p.R273P 17:7673802-7673802 15
25 COSM10859 TP53 lung,NS,carcinoma,large cell carcinoma c.814G>T p.V272L 17:7673806-7673806 15
26 COSM10941 TP53 lung,NS,carcinoma,large cell carcinoma c.730G>A p.G244S 17:7674233-7674233 15
27 COSM10660 TP53 lung,NS,carcinoma,large cell carcinoma c.818G>A p.R273H 17:7673802-7673802 15
28 COSM3849376 TP53 lung,NS,carcinoma,large cell carcinoma c.753C>G p.I251M 17:7674210-7674210 15
29 COSM11081 TP53 lung,NS,carcinoma,large cell carcinoma c.733G>T p.G245C 17:7674230-7674230 15
30 COSM11323 TP53 lung,NS,carcinoma,large cell carcinoma c.482C>A p.A161D 17:7675130-7675130 15
31 COSM44327 TP53 lung,NS,carcinoma,large cell carcinoma c.518T>C p.V173A 17:7675094-7675094 15
32 COSM44623 TP53 lung,NS,carcinoma,large cell carcinoma c.487T>A p.Y163N 17:7675125-7675125 15
33 COSM10654 TP53 lung,NS,carcinoma,large cell carcinoma c.637C>T p.R213* 17:7674894-7674894 15
34 COSM10889 TP53 lung,NS,carcinoma,large cell carcinoma c.536A>G p.H179R 17:7675076-7675076 15
35 COSM10733 TP53 lung,NS,carcinoma,large cell carcinoma c.574C>T p.Q192* 17:7674957-7674957 15
36 COSM43687 TP53 lung,NS,carcinoma,large cell carcinoma c.641A>G p.H214R 17:7674890-7674890 15
37 COSM10646 TP53 lung,NS,carcinoma,large cell carcinoma c.725G>A p.C242Y 17:7674238-7674238 15
38 COSM45677 TP53 lung,NS,carcinoma,large cell carcinoma c.714T>A p.C238* 17:7674249-7674249 15
39 COSM44439 TP53 lung,NS,carcinoma,large cell carcinoma c.656C>T p.P219L 17:7674875-7674875 15
40 COSM10749 TP53 lung,NS,carcinoma,large cell carcinoma c.830G>T p.C277F 17:7673790-7673790 15
41 COSM43947 TP53 lung,NS,carcinoma,large cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 15
42 COSM45675 TP53 lung,NS,carcinoma,large cell carcinoma c.673-1G>C p.? 17:7674291-7674291 15
43 COSM6081949 TP53 lung,NS,carcinoma,large cell carcinoma c.1060C>T p.Q354* 17:7670649-7670649 15
44 COSM10788 TP53 lung,NS,carcinoma,large cell carcinoma c.764T>G p.I255S 17:7674199-7674199 15
45 COSM43626 TP53 lung,NS,carcinoma,large cell carcinoma c.475G>A p.A159T 17:7675137-7675137 15
46 COSM6932 TP53 lung,NS,carcinoma,large cell carcinoma c.733G>A p.G245S 17:7674230-7674230 15
47 COSM44891 TP53 lung,NS,carcinoma,large cell carcinoma c.796G>T p.G266* 17:7673824-7673824 15
48 COSM10750 TP53 lung,NS,carcinoma,large cell carcinoma c.490A>T p.K164* 17:7675122-7675122 15
49 COSM11078 TP53 lung,NS,carcinoma,large cell carcinoma c.1027G>T p.E343* 17:7670682-7670682 15
50 COSM44621 TP53 lung,NS,carcinoma,large cell carcinoma c.718A>T p.S240C 17:7674245-7674245 15
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Expression for Lung Large Cell Carcinoma

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Search GEO for disease gene expression data for Lung Large Cell Carcinoma.
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Pathways for Lung Large Cell Carcinoma

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Pathways related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development HGF signaling pathway 22
Show member pathways
 11.89 CAMK4 MTOR NTRK3 RPS6KA6
2
G-protein signaling RAC1 in cellular process 22
Show member pathways
 11.75 EPHA5 MTOR NTRK3 ROS1
3
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 1
10.96 CAMK4 MTOR NTRK3
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GO Terms for Lung Large Cell Carcinoma

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Cellular components related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.44 CAMK4 CASK CDC42BPB EPHA5 MTOR MYO18B
2 receptor complex GO:0043235 9.13 EPHA5 NTRK3 ROS1

Biological processes related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.7 CAMK4 CASK CDC42BPB EPHA5 MTOR NEK1
2 positive regulation of protein phosphorylation GO:0001934 9.63 MTOR NTRK3 ROS1
3 negative regulation of signal transduction GO:0009968 9.58 EPHA5 NTRK3 ROS1
4 peptidyl-tyrosine phosphorylation GO:0018108 9.55 EPHA5 NEK1 NTRK3 ROS1 TTN
5 positive regulation of neuron projection development GO:0010976 9.54 MTOR NME1 NTRK3
6 activation of protein kinase B activity GO:0032148 9.51 MTOR NTRK3
7 long-term memory GO:0007616 9.49 CAMK4 MTOR
8 regulation of protein kinase activity GO:0045859 9.48 MTOR TTN
9 cardiac muscle fiber development GO:0048739 9.43 MYO18B TTN
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.43 EPHA5 NTRK3 ROS1
11 phosphorylation GO:0016310 9.4 CAMK4 CASK CDC42BPB EPHA5 MTOR NEK1
12 regulation of osteoclast differentiation GO:0045670 9.32 CAMK4 MTOR

Molecular functions related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.97 CAMK4 CASK CDC42BPB EPHA5 MTOR MYO18B
2 protein serine/threonine kinase activity GO:0004674 9.87 CAMK4 CASK CDC42BPB MTOR NEK1 RPS6KA6
3 protein tyrosine kinase activity GO:0004713 9.77 EPHA5 NEK1 NTRK3 ROS1 TTN
4 protein kinase activity GO:0004672 9.7 CAMK4 CASK CDC42BPB EPHA5 MTOR NEK1
5 transmembrane signaling receptor activity GO:0004888 9.69 EPHA5 NTRK3 ROS1
6 magnesium ion binding GO:0000287 9.67 CDC42BPB NME1 RPS6KA6
7 calmodulin binding GO:0005516 9.65 CAMK4 CASK TTN
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.58 EPHA5 NTRK3 ROS1
9 calmodulin-dependent protein kinase activity GO:0004683 9.46 CAMK4 CASK
10 GPI-linked ephrin receptor activity GO:0005004 9.43 EPHA5 NTRK3
11 kinase activity GO:0016301 9.4 CAMK4 CASK CDC42BPB EPHA5 MTOR NEK1
12 transferase activity GO:0016740 10.03 CAMK4 CASK CDC42BPB EPHA5 MTOR NEK1
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Sources for Lung Large Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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