Lung Leiomyoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lung Leiomyoma

MalaCards integrated aliases for Lung Leiomyoma:

Name: Lung Leiomyoma ¹² ¹⁵

Pulmonary Leiomyoma ¹²

Leiomyoma of Lung ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5136

NCIt ⁵¹ C5660

UMLS ⁷⁴ C1334447

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Summaries for Lung Leiomyoma

Disease Ontology : ¹² A lung benign neoplasm that derives from some smooth muscle cell.

MalaCards based summary : Lung Leiomyoma, also known as pulmonary leiomyoma, is related to leiomyoma and myoma. An important gene associated with Lung Leiomyoma is MIR221 (MicroRNA 221), and among its related pathways/superpathways are Cell cycle Role of SCF complex in cell cycle regulation and Signaling by ERBB4. Affiliated tissues include lung and smooth muscle.

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Related Diseases for Lung Leiomyoma

Diseases related to Lung Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)

#	Related Disease	Score	Top Affiliating Genes
1	leiomyoma	29.6	ESR1 PGR
2	myoma	10.0	ESR1 PGR
3	vestibular gland benign neoplasm	10.0	ESR1 PGR
4	bartholin's gland adenoma	10.0	ESR1 PGR
5	vulvar syringoma	10.0	ESR1 PGR
6	glassy cell carcinoma of the cervix	10.0	ESR1 PGR
7	vulvar benign neoplasm	10.0	ESR1 PGR
8	trigonitis	10.0	ESR1 PGR
9	vulvar leiomyoma	10.0	ESR1 PGR
10	predominantly cortical thymoma	10.0	ESR1 PGR
11	breast medullary carcinoma	10.0	ESR1 PGR
12	breast scirrhous carcinoma	10.0	ESR1 PGR
13	bartholin's gland benign neoplasm	10.0	ESR1 PGR
14	oncocytic breast carcinoma	10.0	ESR1 PGR
15	progesterone-receptor positive breast cancer	10.0	ESR1 PGR
16	progesterone resistance	10.0	ESR1 PGR
17	endometrial squamous cell carcinoma	10.0	ESR1 PGR
18	cribriform carcinoma	10.0	ESR1 PGR
19	endometrial mucinous adenocarcinoma	10.0	ESR1 PGR
20	adenoid basal cell carcinoma	9.9	ESR1 PGR
21	apocrine adenocarcinoma	9.9	ESR1 PGR
22	peritoneal benign neoplasm	9.9	ESR1 PGR
23	gender identity disorder	9.9	ESR1 PGR
24	deep angioma	9.9	ESR1 PGR
25	diffuse peritoneal leiomyomatosis	9.9	ESR1 PGR
26	leiomyomatosis	9.9	ESR1 PGR
27	synchronous bilateral breast carcinoma	9.9	ESR1 PGR
28	breast adenoid cystic carcinoma	9.9	ESR1 PGR
29	female reproductive endometrioid cancer	9.9	ESR1 PGR
30	cervical carcinosarcoma	9.9	ESR1 PGR
31	estrogen excess	9.9	ESR1 PGR
32	intramuscular hemangioma	9.9	ESR1 PGR
33	glycogen-rich clear cell breast carcinoma	9.9	ESR1 PGR
34	mammographic density	9.9	ESR1 PGR
35	cervical clear cell adenocarcinoma	9.9	ESR1 PGR
36	retinitis pigmentosa 47	9.9	ESR1 PGR
37	inflammatory breast carcinoma	9.9	ESR1 PGR
38	retinitis pigmentosa 20	9.9	ESR1 PGR
39	adenosarcoma	9.9	ESR1 PGR
40	luminal breast carcinoma	9.9	ESR1 PGR
41	endometriosis of ovary	9.9	ESR1 PGR
42	endometriosis	9.9	ESR1 PGR
43	breast benign neoplasm	9.9	ESR1 PGR
44	thoracic benign neoplasm	9.9	ESR1 PGR
45	uterine corpus cancer	9.9	ESR1 PGR
46	lipid-rich carcinoma	9.9	ESR1 PGR
47	smooth muscle tumor	9.9	ESR1 PGR
48	uterine benign neoplasm	9.9	ESR1 PGR
49	endometritis	9.9	ESR1 PGR
50	prostatic hypertrophy	9.9	ESR1 PGR

Graphical network of the top 20 diseases related to Lung Leiomyoma:

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Symptoms & Phenotypes for Lung Leiomyoma

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Drugs & Therapeutics for Lung Leiomyoma

Search Clinical Trials , NIH Clinical Center for Lung Leiomyoma

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Genetic Tests for Lung Leiomyoma

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Anatomical Context for Lung Leiomyoma

MalaCards organs/tissues related to Lung Leiomyoma:

⁴²

Lung, Smooth Muscle

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Publications for Lung Leiomyoma

Articles related to Lung Leiomyoma:

#	Title	Authors	Year
1	Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. ( 29519996 )	AlAmodi A.A....AlShammari A.	2018
2	Right middle lobectomy for a primary pulmonary leiomyoma: a case report. ( 20184689 )	Vercillo MS...Liptay MJ	2009
3	Pulmonary leiomyoma--a case report. ( 8128743 )	Paik HC...Bae KM	1993
4	Pedunculated pulmonary leiomyoma with large cyst formation. ( 8239825 )	Gotti G...Sforza V	1993
5	Pulmonary leiomyoma. ( 4826252 )	Sabbagh AH...Fritz JM	1974
6	Pulmonary leiomyoma. ( 18730327 )	Reid RH	1970
7	Pulmonary leiomyoma. ( 5362909 )	Sweet RS	1969

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Genes for Lung Leiomyoma

Genes related to Lung Leiomyoma (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MIR221	MicroRNA 221	RNA Gene	350	Causal ⁴⁸	18382364
2	PGR	Progesterone Receptor	Protein Coding	14.24	DISEASES inferred ¹⁵
3	ESR1	Estrogen Receptor 1	Protein Coding	13.99	DISEASES inferred ¹⁵

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Variations for Lung Leiomyoma

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Expression for Lung Leiomyoma

Search GEO for disease gene expression data for Lung Leiomyoma.

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Pathways for Lung Leiomyoma

Pathways related to Lung Leiomyoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cell cycle Role of SCF complex in cell cycle regulation ²³ Show member pathways Cell cycle ESR1 regulation of G1/S transition ²³ Cell cycle Regulation of G1/S transition (part 1) ²³ Immune response MIF-JAB1 signaling ²³	11.4	ESR1 PGR
2	Signaling by ERBB4 ⁶⁷ Show member pathways Downregulation of ERBB4 signaling ⁶⁷ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁷	10.99	ESR1 PGR
3	Nuclear Receptor transcription pathway ⁶⁷ Show member pathways Nuclear Receptors ¹	10.58	ESR1 PGR

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GO Terms for Lung Leiomyoma

Biological processes related to Lung Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	9.32	ESR1 PGR
2	transcription initiation from RNA polymerase II promoter	GO:0006367	9.16	ESR1 PGR
3	transcription, DNA-templated	GO:0006351	8.96	ESR1
4	positive regulation of protein kinase B signaling	GO:0051897	8.96	ESR1 MIR221
5	steroid hormone mediated signaling pathway	GO:0043401	8.62	ESR1 PGR

Molecular functions related to Lung Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATPase binding	GO:0051117	9.26	ESR1 PGR
2	steroid hormone receptor activity	GO:0003707	9.16	ESR1 PGR
3	nuclear receptor activity	GO:0004879	8.96	ESR1 PGR
4	steroid binding	GO:0005496	8.62	ESR1 PGR

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Sources for Lung Leiomyoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

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³¹ HGMD

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³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

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⁴⁵ MeSH

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⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

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⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

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⁵⁶ Novoseek

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⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

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⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia