Lung Leiomyoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lung Leiomyoma

MalaCards integrated aliases for Lung Leiomyoma:

Name: Lung Leiomyoma ¹² ¹⁵

Pulmonary Leiomyoma ¹²

Leiomyoma of Lung ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5136

NCIt ⁵⁰ C5660

SNOMED-CT ⁶⁸ 707374005

UMLS ⁷³ C1334447

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Summaries for Lung Leiomyoma

MalaCards based summary : Lung Leiomyoma, also known as pulmonary leiomyoma, is related to angiomyolipoma and leiomyoma. An important gene associated with Lung Leiomyoma is MIR221 (MicroRNA 221
Benign metastasizing leiomyomas are indeed most likely benign lesions, and up-regulation of miR-221 expression is an accurate way to differentiate leiomyosarcoma from benign metastasizing leiomyoma.), and among its related pathways/superpathways are Cell cycle Role of SCF complex in cell cycle regulation and Signaling by ERBB4. Affiliated tissues include lung.

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Related Diseases for Lung Leiomyoma

Diseases related to Lung Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)

#	Related Disease	Score	Top Affiliating Genes
1	angiomyolipoma	29.2	ESR1 PGR
2	leiomyoma	28.9	ESR1 PGR
3	vulvar syringoma	9.9	ESR1 PGR
4	vestibular gland benign neoplasm	9.9	ESR1 PGR
5	bartholin's gland adenoma	9.9	ESR1 PGR
6	glassy cell carcinoma of the cervix	9.9	ESR1 PGR
7	vulvar benign neoplasm	9.9	ESR1 PGR
8	trigonitis	9.9	ESR1 PGR
9	vulvar leiomyoma	9.9	ESR1 PGR
10	predominantly cortical thymoma	9.9	ESR1 PGR
11	breast medullary carcinoma	9.9	ESR1 PGR
12	breast scirrhous carcinoma	9.9	ESR1 PGR
13	progesterone resistance	9.9	ESR1 PGR
14	progesterone-receptor positive breast cancer	9.9	ESR1 PGR
15	cribriform carcinoma	9.9	ESR1 PGR
16	oncocytic breast carcinoma	9.9	ESR1 PGR
17	endometrial squamous cell carcinoma	9.9	ESR1 PGR
18	gastric signet ring cell adenocarcinoma	9.9	ESR1 PGR
19	endometrial mucinous adenocarcinoma	9.9	ESR1 PGR
20	adenoid basal cell carcinoma	9.9	ESR1 PGR
21	apocrine adenocarcinoma	9.9	ESR1 PGR
22	gender identity disorder	9.9	ESR1 PGR
23	bartholin's gland benign neoplasm	9.9	ESR1 PGR
24	deep angioma	9.9	ESR1 PGR
25	synchronous bilateral breast carcinoma	9.9	ESR1 PGR
26	breast adenoid cystic carcinoma	9.9	ESR1 PGR
27	cervical carcinosarcoma	9.9	ESR1 PGR
28	estrogen excess	9.9	ESR1 PGR
29	intramuscular hemangioma	9.9	ESR1 PGR
30	glycogen-rich clear cell breast carcinoma	9.9	ESR1 PGR
31	mammographic density	9.9	ESR1 PGR
32	retinitis pigmentosa 47	9.9	ESR1 PGR
33	uterine corpus cancer	9.9	ESR1 PGR
34	adenomyosis	9.9	ESR1 PGR
35	retinitis pigmentosa 20	9.9	ESR1 PGR
36	luminal breast carcinoma	9.9	ESR1 PGR
37	adenosarcoma	9.9	ESR1 PGR
38	cervical clear cell adenocarcinoma	9.9	ESR1 PGR
39	breast benign neoplasm	9.9	ESR1 PGR
40	thoracic benign neoplasm	9.9	ESR1 PGR
41	endometriosis of ovary	9.9	ESR1 PGR
42	inflammatory breast carcinoma	9.9	ESR1 PGR
43	mixed cell type cancer	9.9	ESR1 PGR
44	lipid-rich carcinoma	9.9	ESR1 PGR
45	uterine benign neoplasm	9.9	ESR1 PGR
46	reproductive organ benign neoplasm	9.9	ESR1 PGR
47	smooth muscle tumor	9.9	ESR1 PGR
48	pancreatic mucinous cystadenoma	9.9	ESR1 PGR
49	endometritis	9.9	ESR1 PGR
50	prostatic hypertrophy	9.8	ESR1 PGR

Graphical network of the top 20 diseases related to Lung Leiomyoma:

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Symptoms & Phenotypes for Lung Leiomyoma

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Drugs & Therapeutics for Lung Leiomyoma

Search Clinical Trials , NIH Clinical Center for Lung Leiomyoma

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Genetic Tests for Lung Leiomyoma

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Anatomical Context for Lung Leiomyoma

MalaCards organs/tissues related to Lung Leiomyoma:

⁴¹

Lung

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Publications for Lung Leiomyoma

Articles related to Lung Leiomyoma:

#	Title	Authors	Year
1	Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. ( 29519996 )	AlAmodi A.A....AlShammari A.	2018
2	(P016) Bilateral Giant Renal Angiomyolipomas and Lung Leiomyomas Associated With Tuberous Sclerosis: A Case Report. ( 27083655 )		2016

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Genes for Lung Leiomyoma

Genes related to Lung Leiomyoma (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MIR221	MicroRNA 221 Benign metastasizing leiomyomas are indeed most likely benign lesions, and up-regulation of miR-221 expression is an accurate way to differentiate leiomyosarcoma from benign metastasizing leiomyoma.	RNA Gene	350	Causal ⁴⁷	18382364
2	PGR	Progesterone Receptor	Protein Coding	14.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	ESR1	Estrogen Receptor 1	Protein Coding	14.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Lung Leiomyoma

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Expression for Lung Leiomyoma

Search GEO for disease gene expression data for Lung Leiomyoma.

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Pathways for Lung Leiomyoma

Pathways related to Lung Leiomyoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	11.4	ESR1 PGR
2	Signaling by ERBB4 ⁶⁶ Show member pathways Downregulation of ERBB4 signaling ⁶⁶ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁶	10.99	ESR1 PGR
3	Nuclear Receptor transcription pathway ⁶⁶ Show member pathways Nuclear Receptors ¹	10.58	ESR1 PGR

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GO Terms for Lung Leiomyoma

Biological processes related to Lung Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	9.26	ESR1 PGR
2	transcription initiation from RNA polymerase II promoter	GO:0006367	9.16	ESR1 PGR
3	positive regulation of protein kinase B signaling	GO:0051897	8.96	ESR1 MIR221
4	steroid hormone mediated signaling pathway	GO:0043401	8.62	ESR1 PGR

Molecular functions related to Lung Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATPase binding	GO:0051117	9.26	ESR1 PGR
2	steroid hormone receptor activity	GO:0003707	9.16	ESR1 PGR
3	nuclear receptor activity	GO:0004879	8.96	ESR1 PGR
4	steroid binding	GO:0005496	8.62	ESR1 PGR

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Sources for Lung Leiomyoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia