Lung Leiomyoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lung Leiomyoma

MalaCards integrated aliases for Lung Leiomyoma:

Name: Lung Leiomyoma ¹² ¹⁵

Pulmonary Leiomyoma ¹²

Leiomyoma of Lung ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5136

NCIt ⁵⁰ C5660

UMLS ⁷³ C1334447

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Summaries for Lung Leiomyoma

Disease Ontology : ¹² A leiomyoma that is located in the lung.

MalaCards based summary : Lung Leiomyoma, also known as pulmonary leiomyoma, is related to leiomyoma and uterine sarcoma. An important gene associated with Lung Leiomyoma is MIR221 (MicroRNA 221), and among its related pathways/superpathways are Cell cycle Role of SCF complex in cell cycle regulation and Signaling by ERBB4. Affiliated tissues include lung, bone and ovary.

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Related Diseases for Lung Leiomyoma

Diseases related to Lung Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)

#	Related Disease	Score	Top Affiliating Genes
1	leiomyoma	29.6	PGR ESR1
2	uterine sarcoma	10.0	ESR1 MB
3	myoma	10.0	ESR1 PGR
4	vestibular gland benign neoplasm	10.0	ESR1 PGR
5	bartholin's gland adenoma	10.0	ESR1 PGR
6	vulvar syringoma	10.0	ESR1 PGR
7	glassy cell carcinoma of the cervix	10.0	ESR1 PGR
8	vulvar benign neoplasm	10.0	ESR1 PGR
9	trigonitis	10.0	ESR1 PGR
10	vulvar leiomyoma	10.0	ESR1 PGR
11	predominantly cortical thymoma	10.0	ESR1 PGR
12	breast medullary carcinoma	10.0	ESR1 PGR
13	breast scirrhous carcinoma	10.0	ESR1 PGR
14	bartholin's gland benign neoplasm	10.0	ESR1 PGR
15	oncocytic breast carcinoma	10.0	ESR1 PGR
16	progesterone-receptor positive breast cancer	10.0	ESR1 PGR
17	progesterone resistance	10.0	ESR1 PGR
18	endometrial squamous cell carcinoma	10.0	ESR1 PGR
19	cribriform carcinoma	10.0	ESR1 PGR
20	endometrial mucinous adenocarcinoma	10.0	ESR1 PGR
21	adenoid basal cell carcinoma	10.0	ESR1 PGR
22	breast adenoid cystic carcinoma	10.0	ESR1 PGR
23	apocrine adenocarcinoma	10.0	ESR1 PGR
24	peritoneal benign neoplasm	10.0	ESR1 PGR
25	gender identity disorder	10.0	ESR1 PGR
26	deep angioma	10.0	ESR1 PGR
27	diffuse peritoneal leiomyomatosis	10.0	ESR1 PGR
28	leiomyomatosis	10.0	ESR1 PGR
29	synchronous bilateral breast carcinoma	10.0	ESR1 PGR
30	female reproductive endometrioid cancer	10.0	ESR1 PGR
31	cervical carcinosarcoma	10.0	ESR1 PGR
32	estrogen excess	10.0	ESR1 PGR
33	intramuscular hemangioma	10.0	ESR1 PGR
34	glycogen-rich clear cell breast carcinoma	10.0	ESR1 PGR
35	mammographic density	10.0	ESR1 PGR
36	cervical clear cell adenocarcinoma	10.0	ESR1 PGR
37	retinitis pigmentosa 47	10.0	ESR1 PGR
38	inflammatory breast carcinoma	10.0	ESR1 PGR
39	retinitis pigmentosa 20	10.0	ESR1 PGR
40	luminal breast carcinoma	10.0	ESR1 PGR
41	endometriosis of ovary	10.0	ESR1 PGR
42	endometriosis	10.0	PGR ESR1
43	breast benign neoplasm	10.0	ESR1 PGR
44	thoracic benign neoplasm	10.0	ESR1 PGR
45	uterine corpus cancer	10.0	ESR1 PGR
46	lipid-rich carcinoma	10.0	ESR1 PGR
47	smooth muscle tumor	10.0	ESR1 PGR
48	uterine benign neoplasm	10.0	ESR1 PGR
49	mixed cell type cancer	9.9	MB PGR
50	endometritis	9.9	ESR1 PGR

Graphical network of the top 20 diseases related to Lung Leiomyoma:

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Symptoms & Phenotypes for Lung Leiomyoma

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Drugs & Therapeutics for Lung Leiomyoma

Search Clinical Trials , NIH Clinical Center for Lung Leiomyoma

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Genetic Tests for Lung Leiomyoma

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Anatomical Context for Lung Leiomyoma

MalaCards organs/tissues related to Lung Leiomyoma:

⁴¹

Lung, Bone, Ovary, Prostate, Cervix, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Leiomyoma:

¹⁹

The Lung

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Publications for Lung Leiomyoma

Articles related to Lung Leiomyoma:

#	Title	Authors	Year
1	Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy. ( 29519996 )	AlAmodi A.A....AlShammari A.	2018
2	Right middle lobectomy for a primary pulmonary leiomyoma: a case report. ( 20184689 )	Vercillo MS...Liptay MJ	2009
3	Pulmonary leiomyoma--a case report. ( 8128743 )	Paik HC...Bae KM	1993
4	Pedunculated pulmonary leiomyoma with large cyst formation. ( 8239825 )	Gotti G...Sforza V	1993
5	Pulmonary leiomyoma. ( 4826252 )	Sabbagh AH...Fritz JM	1974
6	Pulmonary leiomyoma. ( 18730327 )	Reid RH	1970
7	Pulmonary leiomyoma. ( 5362909 )	Sweet RS	1969

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Genes for Lung Leiomyoma

Genes related to Lung Leiomyoma (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MIR221	MicroRNA 221	RNA Gene	350	Causal ⁴⁷	18382364
2	MB	Myoglobin	Protein Coding	16.42	GeneCards inferred via : Publications (show sections)
3	PGR	Progesterone Receptor	Protein Coding	14.22	DISEASES inferred ¹⁵
4	ESR1	Estrogen Receptor 1	Protein Coding	14.03	DISEASES inferred ¹⁵

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Variations for Lung Leiomyoma

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Expression for Lung Leiomyoma

Search GEO for disease gene expression data for Lung Leiomyoma.

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Pathways for Lung Leiomyoma

Pathways related to Lung Leiomyoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	11.4	ESR1 PGR
2	Signaling by ERBB4 ⁶⁶ Show member pathways Downregulation of ERBB4 signaling ⁶⁶ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁶	10.99	ESR1 PGR
3	Nuclear Receptor transcription pathway ⁶⁶ Show member pathways Nuclear Receptors ¹	10.58	ESR1 PGR

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GO Terms for Lung Leiomyoma

Biological processes related to Lung Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription initiation from RNA polymerase II promoter	GO:0006367	9.16	ESR1 PGR
2	positive regulation of protein kinase B signaling	GO:0051897	8.96	ESR1 MIR221
3	steroid hormone mediated signaling pathway	GO:0043401	8.62	ESR1 PGR

Molecular functions related to Lung Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATPase binding	GO:0051117	9.26	ESR1 PGR
2	steroid hormone receptor activity	GO:0003707	9.16	ESR1 PGR
3	nuclear receptor activity	GO:0004879	8.96	ESR1 PGR
4	steroid binding	GO:0005496	8.62	ESR1 PGR

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Sources for Lung Leiomyoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁶ DrugBank

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

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³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia