MCID: LNG013
MIFTS: 42

Lung Lymphoma

Categories: Cancer diseases, Immune diseases, Respiratory diseases

Aliases & Classifications for Lung Lymphoma

MalaCards integrated aliases for Lung Lymphoma:

Name: Lung Lymphoma 12 15
Pulmonary Lymphoma 12 73
Primary Lung Lymphoma 73
Lymphoma of Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6760

Summaries for Lung Lymphoma

MalaCards based summary : Lung Lymphoma, also known as pulmonary lymphoma, is related to lymphoma and primary pulmonary lymphoma. An important gene associated with Lung Lymphoma is MALT1 (MALT1 Paracaspase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs rituximab and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include lung and b cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Lung Lymphoma

Diseases related to Lung Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 lymphoma 28.7 ALK BCL6 MALT1 PAX5 TNFRSF8
2 primary pulmonary lymphoma 12.0
3 parapharyngeal meningioma 11.0 CR2 SMUG1
4 selective igg deficiency disease 11.0 CD40LG CD79A
5 c1q nephropathy 11.0 CD40LG CD79A
6 cardiovascular syphilis 11.0 CD40LG SMUG1
7 meningovascular neurosyphilis 11.0 CD40LG CD79A
8 alpha chain disease 10.9 CD40LG CD79A
9 brill-zinsser disease 10.9 CD40LG CD79A
10 exudative glomerulonephritis 10.9 CD40LG CD79A
11 cork-handlers' disease 10.9 CD40LG CD79A
12 salpingo-oophoritis 10.9 CD40LG CD79A
13 hemangioma of spleen 10.9 CR2 SMUG1
14 ventilation pneumonitis 10.9 CD40LG CD79A
15 chronic interstitial cystitis 10.9 CD40LG CD79A
16 axillary adenitis 10.9 CD40LG CD79A
17 cryofibrinogenemia 10.9 CD40LG CD79A
18 immunodeficiency, common variable, 2 10.9 CD19 CR2
19 trichostrongyloidiasis 10.9 CD40LG CD79A
20 subacute bacterial endocarditis 10.9 CD40LG CD79A
21 heterophyiasis 10.9 CD40LG CD79A
22 immunoglobulin g deficiency 10.9 CD40LG CD79A
23 orbital granuloma 10.9 CD40LG CD79A
24 hyperglobulinemic purpura 10.9 CD40LG CD79A
25 gastroduodenitis 10.9 CD40LG CD79A
26 bacterial conjunctivitis 10.9 CD40LG CD79A
27 lobomycosis 10.9 CD19 CR2
28 kyasanur forest disease 10.9 ALK CD40LG
29 heavy chain disease 10.8 CD40LG CD79A
30 ophthalmia neonatorum 10.8 CD40LG CD79A
31 encephalitozoonosis 10.8 CD19 CD40LG
32 immunoglobulin a deficiency 1 10.8 CD40LG CD79A
33 parotid disease 10.8 CD40LG CD79A
34 duodenitis 10.8 CD79A MALT1
35 selective immunoglobulin deficiency disease 10.8 CD40LG CD79A
36 cryoglobulinemia, familial mixed 10.8 CD40LG CD5
37 geniculate herpes zoster 10.8 CD40LG CD79A
38 gallbladder small cell carcinoma 10.8 NCAM1 SMUG1
39 tolosa-hunt syndrome 10.7 CD40LG SMUG1
40 erythema elevatum diutinum 10.7 CD40LG CD79A
41 nodal marginal zone b-cell lymphoma 10.7 BCL6 MALT1
42 transient hypogammaglobulinemia of infancy 10.7 CD19 CD40LG CD79A
43 lymphoplasmacytic lymphoma 10.7 CD40LG CD5 PAX5
44 posterior scleritis 10.7 CD19 CD22
45 fournier gangrene 10.7 CD40LG F8
46 sporotrichosis 10.7 CD40LG CD79A
47 gamma heavy chain disease 10.7 CD19 CD40LG CD79A
48 non-secretory myeloma 10.7 CD40LG CD79A SMUG1
49 fallopian tube disease 10.7 CD40LG CD79A
50 hyperimmunoglobulin syndrome 10.7 CD40LG CD79A

Graphical network of the top 20 diseases related to Lung Lymphoma:



Diseases related to Lung Lymphoma

Symptoms & Phenotypes for Lung Lymphoma

MGI Mouse Phenotypes related to Lung Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 TNFRSF8 CD22 MALT1 CD40LG PAX5 CD5
2 homeostasis/metabolism MP:0005376 10.03 SMUG1 CD19 IL1A CD40LG RHOJ CD79A
3 immune system MP:0005387 10 TNFRSF8 IL1A CD22 MALT1 CD40LG PAX5
4 mortality/aging MP:0010768 9.77 SMUG1 CD22 MALT1 NCAM1 CD40LG PAX5
5 neoplasm MP:0002006 9.23 SMUG1 IL1A PAX5 RHOJ CD79A ALK

Drugs & Therapeutics for Lung Lymphoma

Drugs for Lung Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 3 174722-31-7 10201696
2
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
3
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
4
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
5
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
6
Doxil Approved June 1999 Phase 3 31703
7 Alkylating Agents Phase 3
8 glucocorticoids Phase 3
9 Topoisomerase Inhibitors Phase 3
10 Hormone Antagonists Phase 3
11 Hormones Phase 3
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
13 Anti-Bacterial Agents Phase 3
14 Antibiotics, Antitubercular Phase 3
15 Immunosuppressive Agents Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Antirheumatic Agents Phase 3
18 Bendamustine Hydrochloride Phase 3
19 Antimitotic Agents Phase 3
20 Antineoplastic Agents, Alkylating Phase 3
21 Antineoplastic Agents, Hormonal Phase 3
22 Antineoplastic Agents, Phytogenic Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Bendamustine Hydrochloride and Rituximab (BR) Compared With R-CVP or R-CHOP in the First-Line Treatment of Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) - Referred to as the BRIGHT Study Completed NCT00877006 Phase 3 bendamustine;rituximab;vincristine;prednisone;cyclophosphamide;doxorubicin

Search NIH Clinical Center for Lung Lymphoma

Genetic Tests for Lung Lymphoma

Anatomical Context for Lung Lymphoma

MalaCards organs/tissues related to Lung Lymphoma:

41
Lung, B Cells

Publications for Lung Lymphoma

Articles related to Lung Lymphoma:

(show top 50) (show all 58)
# Title Authors Year
1
Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study. ( 29530011 )
2018
2
Lung lymphoma with ground glass opacity CT image. ( 28158804 )
2017
3
Primary Pulmonary Lymphoma Presenting with Superior Vena Cava Syndrome in a Young Female. ( 28932613 )
2017
4
Unilateral lung infiltrate: A rare form of presentation of primary pulmonary lymphoma. ( 28757282 )
2017
5
Primary pulmonary lymphoma: four different and unusual radiologic and clinical manifestations. ( 27658461 )
2016
6
Primary pulmonary lymphoma-role of fluoro-deoxy-glucose positron emission tomography-computed tomography in the initial staging and evaluating response to treatment - case reports and review of literature. ( 27385889 )
2016
7
Primary Pulmonary Lymphoma and Synchronous Cecal Adenocarcinoma: A Rare Occurrence. ( 28133582 )
2016
8
Primary pulmonary lymphoma mimicking a refractory lung abscess: A case report. ( 25789003 )
2015
9
Synchronous primary pulmonary lymphoma presenting with pulmonary adenocarcinoma: A case report and literature review. ( 26548938 )
2015
10
Primary pulmonary lymphoma in a patient with advanced AIDS. ( 25527680 )
2014
11
Primary pulmonary lymphoma and cutaneous metastasis: a case report. ( 25763075 )
2014
12
Unusual radiologic and histologic manifestations of primary pulmonary lymphoma. ( 24585921 )
2014
13
Primary pulmonary lymphoma presenting with multiple lung nodules. ( 25360736 )
2014
14
Primary pulmonary lymphoma: About five cases and literature review. ( 24669084 )
2014
15
Primary Pulmonary Lymphoma: A Case of 'Unresolving Pneumonia' ( 24365165 )
2013
16
Primary lung lymphoma involving the superior vena cava. ( 22748025 )
2012
17
Forty years literature review of primary lung lymphoma. ( 21371331 )
2011
18
Primary cutaneous diffuse large B cell lymphoma relapsed solely as a huge lung tumor mimicking a primary pulmonary lymphoma. ( 20012513 )
2010
19
Lung resection for treatment of idiopathic thrombocytopenic purpura associated with a pulmonary lymphoma. ( 19766775 )
2009
20
Pulmonary lymphoma identified as a result of low-dose CT screening for lung cancer. ( 18603180 )
2008
21
Primary pulmonary lymphoma disguised as asthma. ( 16612936 )
2006
22
Primary pulmonary lymphoma: current status. ( 16354327 )
2005
23
Unusual chest lesion: giant primary pulmonary lymphoma. ( 16122515 )
2005
24
Primary pulmonary lymphoma: diagnosis and follow-up of 6 cases and review of an uncommon entity. ( 15850001 )
2005
25
Primary pulmonary lymphoma. ( 16181848 )
2005
26
Yellow nail syndrome and lung lymphoma. ( 15245553 )
2004
27
Primary lung lymphoma. ( 15584896 )
2004
28
Primary pulmonary lymphoma presenting as lung mass. ( 12683716 )
2003
29
Primary pulmonary lymphoma. ( 12358356 )
2002
30
Nodular amyloidoma and primary pulmonary lymphoma with amyloid production: a differential diagnostic problem. ( 11007032 )
2000
31
Primary pulmonary lymphoma. ( 10375087 )
1999
32
Early stage primary pulmonary lymphoma. ( 9458308 )
1998
33
AIDS-related primary pulmonary lymphoma. ( 9769285 )
1998
34
Primary pulmonary lymphoma--clinical review from a single institution in Singapore. ( 9373207 )
1997
35
Monoclonality of B-cell lineage in primary pulmonary lymphoma demonstrated by immunoglobulin heavy chain gene sequence analysis of histologically non-definitive transbronchial biopsy specimens. ( 8778338 )
1996
36
Primary pulmonary lymphoma: report of a case diagnosed by transbronchial biopsy. ( 8941701 )
1996
37
Primary pulmonary lymphoma diagnosed by gene rearrangement: report of a case. ( 8782309 )
1996
38
Primary pulmonary lymphoma. ( 7660226 )
1995
39
Primary pulmonary lymphoma: relationship between clinical features and pathologic findings in 24 cases. The Japan National Chest Hospital Study Group for Lung Cancer. ( 7666590 )
1995
40
A unique chromosome translocation, t(11;12;18)(q21;q13;q21) [correction of t(11;12;18)(q13;q13;q12)], in primary lung lymphoma. ( 7627935 )
1995
41
Primary pulmonary lymphoma: report of three cases and a brief review of the literature. ( 7944259 )
1994
42
Primary pulmonary lymphoma. Report of a case diagnosed by fine needle aspiration cytology. ( 8042431 )
1994
43
Lobar primary pulmonary lymphoma: iodine-123-iodoamphetamine and thallium-201-chloride scintigraphic findings. ( 8229244 )
1993
44
[A case of primary pulmonary lymphoma associated with SjAPgren syndrome and IgM monoclonal gammopathy confirmed by DNA rearrangement]. ( 8468823 )
1993
45
Primary pulmonary lymphoma. Diagnosis by immunoglobulin gene rearrangement study using a novel polymerase chain reaction technique. ( 8317803 )
1993
46
Epstein-Barr virus and primary lung lymphoma: a study utilizing the polymerase chain reaction. ( 8248115 )
1993
47
CT "angiogram sign" in primary pulmonary lymphoma. ( 1326009 )
1992
48
Lobar primary pulmonary lymphoma: CT findings. ( 2061489 )
1991
49
MR imaging of primary pulmonary lymphoma. ( 2092668 )
1990
50
Primary pulmonary lymphoma in a patient with the acquired immune deficiency syndrome. ( 2763248 )
1989

Variations for Lung Lymphoma

Expression for Lung Lymphoma

Search GEO for disease gene expression data for Lung Lymphoma.

Pathways for Lung Lymphoma

Pathways related to Lung Lymphoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 BCL6 BIRC3 CD19 CD22 CD40LG CD79A
2
Show member pathways
13.18 BCL6 BIRC3 CD40LG HCK IL1A NCAM1
3
Show member pathways
12.63 CD19 CD79A CR2 IL1A MALT1
4
Show member pathways
12.33 BCL6 CD19 CD22 CD79A CR2
5 12.17 BCL6 CD19 CD40LG CD79A GZMB HCK
6
Show member pathways
12.13 BCL6 CD19 CD22 MALT1
7
Show member pathways
12.11 BCL6 CD19 CD22 CD79A CR2 MALT1
8 12.03 BCL6 BIRC3 GZMB PAX5
9 12 BIRC3 CD40LG GZMB MALT1
10 11.78 CD19 CD22 CD5 CD79A NCAM1
11
Show member pathways
11.77 CD19 CD22 CD79A
12 11.71 BIRC3 CD40LG MALT1
13
Show member pathways
11.55 BIRC3 CD40LG TNFRSF8
14 11.54 CD19 CD22 CD5 CR2 IL1A
15
Show member pathways
11.45 BIRC3 CD40LG IL1A
16 11.11 CD19 CD40LG CD79A
17 10.95 BCL6 CD19 CD22 CD40LG CD5 CR2

GO Terms for Lung Lymphoma

Cellular components related to Lung Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 ALK CD19 CD22 CD40LG CD5 CD79A
2 external side of plasma membrane GO:0009897 9.02 CD19 CD40LG CD5 CD79A NCAM1

Biological processes related to Lung Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.72 BCL6 CD40LG HCK IL1A TNFRSF8
2 regulation of cell proliferation GO:0042127 9.67 ALK BCL6 HCK TNFRSF8
3 regulation of apoptotic process GO:0042981 9.65 ALK BCL6 BIRC3 MALT1 TNFRSF8
4 negative regulation of apoptotic process GO:0043066 9.63 ALK BCL6 BIRC3 CD40LG HCK MALT1
5 regulation of inflammatory response GO:0050727 9.58 BCL6 BIRC3 HCK
6 B cell proliferation GO:0042100 9.13 CD40LG CD79A CR2
7 B cell differentiation GO:0030183 8.92 BCL6 CD40LG CD79A CR2

Molecular functions related to Lung Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.6 ALK BCL6 BIRC3 CD19 CD22 CD40LG
2 transmembrane signaling receptor activity GO:0004888 9.35 ALK CD5 CD79A CR2 TNFRSF8

Sources for Lung Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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