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MCID: LNG013
MIFTS: 42

Lung Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lung Lymphoma

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MalaCards integrated aliases for Lung Lymphoma:

Name: Lung Lymphoma 12 15
Pulmonary Lymphoma 12 73
Primary Lung Lymphoma 73
Lymphoma of Lung 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases Respiratory diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6760
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Summaries for Lung Lymphoma

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MalaCards based summary : Lung Lymphoma, also known as pulmonary lymphoma, is related to intravascular large b-cell lymphoma and lymphoma. An important gene associated with Lung Lymphoma is MALT1 (MALT1 Paracaspase), and among its related pathways/superpathways are Innate Immune System and Immune response Fc epsilon RI pathway. The drugs Cyclophosphamide and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and b cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Lung Lymphoma

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Diseases related to Lung Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 intravascular large b-cell lymphoma 29.9 BCL6 CD5
2 lymphoma 29.7 ALK BCL6 MALT1 PAX5 TNFRSF8
3 marginal zone b-cell lymphoma 29.4 BCL6 BIRC3 CD5 CD79A MALT1
4 lymphosarcoma 29.3 BCL6 CD22 CD5 CD79A SMUG1
5 b-cell lymphomas 29.2 BCL6 BIRC3 CD5 MALT1 PAX5 TNFRSF8
6 anaplastic large cell lymphoma 29.2 ALK GZMB PAX5 TNFRSF8
7 lymphoma, mucosa-associated lymphoid type 29.1 BCL6 BIRC3 CD19 CD5 CD79A MALT1
8 diffuse large b-cell lymphoma 29.0 BCL6 CD5 CD79A MALT1 TNFRSF8
9 leukemia, chronic lymphocytic 28.6 BCL6 CD19 CD5 CR2 IL1A PAX5
10 primary pulmonary lymphoma 12.2
11 gray zone lymphoma 10.3 CD79A PAX5
12 parapharyngeal meningioma 10.3 CR2 SMUG1
13 hemangioma of spleen 10.3 CR2 SMUG1
14 immunodeficiency, common variable, 2 10.3 CD19 CR2
15 lobomycosis 10.3 CD19 CR2
16 gallbladder small cell carcinoma 10.2 NCAM1 SMUG1
17 posterior scleritis 10.2 CD19 CD22
18 viral esophagitis 10.2 CD79A GZMB
19 nodal marginal zone b-cell lymphoma 10.2 BCL6 MALT1
20 pericoronitis 10.2 CD19 NCAM1
21 spleen cancer 10.2 CR2 F8
22 agammaglobulinemia 10.2 CD19 CD79A CR2
23 cryoglobulinemia 10.2 CD5 CD79A CR2
24 rhinoscleroma 10.2 CD19 NCAM1
25 nodular lymphocyte predominant hodgkin lymphoma 10.2 BCL6 PAX5
26 b cell prolymphocytic leukemia 10.2 CD19 CD5
27 selective igg deficiency disease 10.2 CD19 CD79A NCAM1
28 orbit lymphoma 10.2 GZMB NCAM1
29 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 BCL6 CR2
30 transient hypogammaglobulinemia of infancy 10.2 ALK CD19 CR2
31 plasma cell neoplasm 10.2 CD19 CD79A NCAM1
32 chromosomal triplication 10.2 BCL6 MALT1
33 small intestine lymphoma 10.2 CD19 CD22 CD79A
34 primary cutaneous anaplastic large cell lymphoma 10.2 ALK GZMB
35 lateral medullary syndrome 10.2 CD19 CD22 CR2
36 breast angiosarcoma 10.1 F8 SMUG1
37 subcutaneous panniculitis-like t-cell lymphoma 10.1 GZMB NCAM1
38 intraocular lymphoma 10.1 BCL6 PAX5
39 waldenstroem's macroglobulinemia 10.1 CD19 CD5
40 castleman disease 10.1 BCL6 CR2 PAX5
41 parasitic ichthyosporea infectious disease 10.1 NCAM1 RHOJ
42 non-secretory myeloma 10.1 CD19 SMUG1
43 rhinosporidiosis 10.1 NCAM1 RHOJ
44 lymphomatoid papulosis 10.1 ALK GZMB
45 prostate lymphoma 10.1 BIRC3 CD5 MALT1 SMUG1
46 autoimmune lymphoproliferative syndrome, type v 10.1 ALK BCL6 CD5
47 ileum cancer 10.1 CD5 GZMB NCAM1
48 primary central nervous system lymphoma 10.1 BCL6 PAX5
49 mediastinal cancer 10.1 CD5 CD79A NCAM1 SMUG1
50 natural killer cell leukemia 10.1 GZMB NCAM1

Graphical network of the top 20 diseases related to Lung Lymphoma:



Diseases related to Lung Lymphoma
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Symptoms & Phenotypes for Lung Lymphoma

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MGI Mouse Phenotypes related to Lung Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 BCL6 BIRC3 CD19 CD22 CD5 CD79A
2 homeostasis/metabolism MP:0005376 10 ALK BCL6 BIRC3 CD19 CD79A CR2
3 immune system MP:0005387 9.97 BCL6 BIRC3 CD19 CD22 CD5 CD79A
4 mortality/aging MP:0010768 9.73 ALK BCL6 BIRC3 CD19 CD22 CR2
5 neoplasm MP:0002006 9.23 ALK CD19 CD79A HCK IL1A PAX5
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Drugs & Therapeutics for Lung Lymphoma

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Drugs for Lung Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
2
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
3
rituximab Approved Phase 3 174722-31-7 10201696
4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
5
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
6
Doxil Approved June 1999 Phase 3 31703
7 Hormones Phase 3
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
9 Antineoplastic Agents, Hormonal Phase 3
10 Alkylating Agents Phase 3
11 glucocorticoids Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Antirheumatic Agents Phase 3
14 Bendamustine Hydrochloride Phase 3
15 Anti-Bacterial Agents Phase 3
16 Hormone Antagonists Phase 3
17 Antineoplastic Agents, Phytogenic Phase 3
18 Antimitotic Agents Phase 3
19 Antineoplastic Agents, Alkylating Phase 3
20 Antibiotics, Antitubercular Phase 3
21 Immunologic Factors Phase 3
22 Topoisomerase Inhibitors Phase 3
23 Immunosuppressive Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Bendamustine Hydrochloride and Rituximab (BR) Compared With R-CVP or R-CHOP in the First-Line Treatment of Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) - Referred to as the BRIGHT Study Completed NCT00877006 Phase 3 bendamustine;rituximab;vincristine;prednisone;cyclophosphamide;doxorubicin

Search NIH Clinical Center for Lung Lymphoma

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Genetic Tests for Lung Lymphoma

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Anatomical Context for Lung Lymphoma

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MalaCards organs/tissues related to Lung Lymphoma:

41
Lung, Prostate, B Cells, T Cells, Bone, Spleen, Thymus
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Publications for Lung Lymphoma

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Articles related to Lung Lymphoma:

(show top 50) (show all 95)
# Title Authors Year
1
Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study. ( 29530011 )
2018
2
Diagnostic and Therapeutic Implications of Pulmonary Lymphoma Associated with Nodular Amyloidosis. ( 30395852 )
2018
3
Unilateral lung infiltrate: A rare form of presentation of primary pulmonary lymphoma. ( 28757282 )
2018
4
Synchronous Primary Central Nervous System and Pulmonary Lymphoma in a 7-Year-Old Female with Unspecified T-Cell Immunodeficiency. ( 30110687 )
2018
5
Contrast-Enhanced Ultrasound in Pulmonary Lymphoma: A Small Pilot Study. ( 29732588 )
2018
6
An unusual presentation of pulmonary lymphoma: When diffuse ground glass opacities can mean anything. ( 29905415 )
2018
7
Lung lymphoma with ground glass opacity CT image. ( 28158804 )
2017
8
Primary Pulmonary Lymphoma Presenting with Superior Vena Cava Syndrome in a Young Female. ( 28932613 )
2017
9
Pulmonary Lymphoma. A Case Report. ( 27979637 )
2017
10
Significance of imaging and clinical features in the differentiation between primary and secondary pulmonary lymphoma. ( 29113271 )
2017
11
Primary pulmonary lymphoma: four different and unusual radiologic and clinical manifestations. ( 27658461 )
2016
12
Primary pulmonary lymphoma-role of fluoro-deoxy-glucose positron emission tomography-computed tomography in the initial staging and evaluating response to treatment - case reports and review of literature. ( 27385889 )
2016
13
Primary Pulmonary Lymphoma and Synchronous Cecal Adenocarcinoma: A Rare Occurrence. ( 28133582 )
2016
14
Pulmonary Lymphoma Misdiagnosed as Pneumonia. ( 27812267 )
2016
15
Primary pulmonary lymphoma mimicking a refractory lung abscess: A case report. ( 25789003 )
2015
16
Synchronous primary pulmonary lymphoma presenting with pulmonary adenocarcinoma: A case report and literature review. ( 26548938 )
2015
17
Primary pulmonary lymphoma in a patient with advanced AIDS. ( 25527680 )
2014
18
Primary pulmonary lymphoma and cutaneous metastasis: a case report. ( 25763075 )
2014
19
Unusual radiologic and histologic manifestations of primary pulmonary lymphoma. ( 24585921 )
2014
20
Primary pulmonary lymphoma presenting with multiple lung nodules. ( 25360736 )
2014
21
Primary pulmonary lymphoma: About five cases and literature review. ( 24669084 )
2014
22
Primary Pulmonary Lymphoma: A Case of 'Unresolving Pneumonia' ( 24365165 )
2013
23
Primary lung lymphoma involving the superior vena cava. ( 22748025 )
2012
24
Forty years literature review of primary lung lymphoma. ( 21371331 )
2011
25
Discrimination between invasive pulmonary aspergillosis and pulmonary lymphoma using CT. ( 19804951 )
2011
26
The reversed halo sign. Another CT finding useful for distinguish invasive pulmonary aspergillosis and pulmonary lymphoma. ( 21546185 )
2011
27
Primary cutaneous diffuse large B cell lymphoma relapsed solely as a huge lung tumor mimicking a primary pulmonary lymphoma. ( 20012513 )
2010
28
Radiographic appearance of confirmed pulmonary lymphoma in cats and dogs. ( 20806869 )
2010
29
Lung resection for treatment of idiopathic thrombocytopenic purpura associated with a pulmonary lymphoma. ( 19766775 )
2009
30
Pulmonary lymphoma mimicking metastases: a case report. ( 19829905 )
2009
31
Pulmonary lymphoma identified as a result of low-dose CT screening for lung cancer. ( 18603180 )
2008
32
Intravascular pulmonary lymphoma with good response to treatment. A case report. ( 19023499 )
2008
33
Gastric and pulmonary lymphoma presenting as a solitary pulmonary nodule. ( 21614299 )
2007
34
Pulmonary lymphoma developed during long-term methotrexate therapy for psoriasis. ( 17875071 )
2007
35
Primary pulmonary lymphoma disguised as asthma. ( 16612936 )
2006
36
Pulmonary lymphoma of mucosa-associated lymphoid tissue type followed as a long-standing indeterminate lesion in immunoglobulin M-type paraproteinemia. ( 16898643 )
2006
37
Primary pulmonary lymphoma: current status. ( 16354327 )
2005
38
Unusual chest lesion: giant primary pulmonary lymphoma. ( 16122515 )
2005
39
Primary pulmonary lymphoma: diagnosis and follow-up of 6 cases and review of an uncommon entity. ( 15850001 )
2005
40
Primary pulmonary lymphoma. ( 16181848 )
2005
41
EUS-guided biopsy in the diagnosis of pulmonary lymphoma in a patient with an esophagopulmonary fistula. ( 15933699 )
2005
42
Pulmonary lymphoma of the mucosa-associated lymphoid tissue type: Report of a case with cytological, histological, immunophenotypical correlation, and review of the literature. ( 15944957 )
2005
43
Yellow nail syndrome and lung lymphoma. ( 15245553 )
2004
44
Primary lung lymphoma. ( 15584896 )
2004
45
Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonary lymphoma. ( 15070704 )
2004
46
What is your diagnosis? Pulmonary lymphoma. ( 15154724 )
2004
47
Primary pulmonary lymphoma presenting as lung mass. ( 12683716 )
2003
48
Methotrexate-induced pulmonary lymphoma. ( 12796204 )
2003
49
Primary pulmonary lymphoma. ( 12358356 )
2002
50
Pulmonary lymphoma of large B-cell type mimicking Wegener's granulomatosis. ( 11518126 )
2001
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Variations for Lung Lymphoma

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Expression for Lung Lymphoma

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Search GEO for disease gene expression data for Lung Lymphoma.
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Pathways for Lung Lymphoma

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Pathways related to Lung Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.77 BCL6 BIRC3 CD19 CD22 CD79A HCK
2
Immune response Fc epsilon RI pathway 22
Show member pathways
 12.3 BCL6 CD19 CD22 CD79A CR2
3
NF-kappaB Signaling 4
12.12 BCL6 CD19 CD79A GZMB HCK MALT1
4
B cell receptor signaling pathway (KEGG) 37
Show member pathways
 12.11 BCL6 CD19 CD22 CD79A CR2 MALT1
5
B Cell Receptor Signaling Pathway (sino) 67
Show member pathways
 12.06 BCL6 CD19 CD22 MALT1
6
Transcriptional misregulation in cancer 37
11.97 BCL6 BIRC3 GZMB PAX5
7
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.78 CD19 CD22 CD5 CD79A NCAM1
8
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 66
Show member pathways
 11.66 CD19 CD22 CD79A
9
Hematopoietic cell lineage 37
11.54 CD19 CD22 CD5 CR2 IL1A
10
B Cell Development Pathways 65
10.89 BCL6 CD19 CD22 CD5 CR2 PAX5
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GO Terms for Lung Lymphoma

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Cellular components related to Lung Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 ALK CD19 CD22 CD5 CD79A CR2
2 external side of plasma membrane GO:0009897 8.92 CD19 CD5 CD79A NCAM1

Biological processes related to Lung Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.65 ALK BCL6 BIRC3 HCK MALT1
2 regulation of apoptotic process GO:0042981 9.46 ALK BCL6 BIRC3 MALT1
3 NIK/NF-kappaB signaling GO:0038061 9.32 ALK BIRC3
4 B cell differentiation GO:0030183 9.13 BCL6 CD79A CR2
5 regulation of inflammatory response GO:0050727 8.8 BCL6 BIRC3 HCK

Molecular functions related to Lung Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 ALK BCL6 BIRC3 CD19 CD22 CD5
2 transmembrane signaling receptor activity GO:0004888 9.02 ALK CD5 CD79A CR2 TNFRSF8
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Sources for Lung Lymphoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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