MCID: LNG091
MIFTS: 35

Lung Mucoepidermoid Carcinoma

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Lung Mucoepidermoid Carcinoma

MalaCards integrated aliases for Lung Mucoepidermoid Carcinoma:

Name: Lung Mucoepidermoid Carcinoma 11 14
Mucoepidermoid Carcinoma of Lung 71

Classifications:



External Ids:

Disease Ontology 11 DOID:0050932
UMLS 71 C1708778

Summaries for Lung Mucoepidermoid Carcinoma

Disease Ontology: 11 A lung carcinoma that has material basis in a combination of squamous cells, mucus secreting cells and intermediate cells.

MalaCards based summary: Lung Mucoepidermoid Carcinoma, also known as mucoepidermoid carcinoma of lung, is related to mucoepidermoid carcinoma and intrahepatic biliary papillomatosis, and has symptoms including hemoptysis and wheezing. An important gene associated with Lung Mucoepidermoid Carcinoma is MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and O-linked glycosylation of mucins. Affiliated tissues include lung, brain and neutrophil.

Related Diseases for Lung Mucoepidermoid Carcinoma

Diseases related to Lung Mucoepidermoid Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 mucoepidermoid carcinoma 10.4
2 intrahepatic biliary papillomatosis 10.3 MUC5B MUC5AC
3 biliary papillomatosis 10.3 MUC5B MUC5AC
4 colloid carcinoma of the pancreas 10.3 MUC5B MUC5AC
5 bile duct mucinous adenocarcinoma 10.3 MUC5B MUC5AC
6 bile duct mucoepidermoid carcinoma 10.3 MUC5B MUC5AC
7 bile duct cystadenocarcinoma 10.2 MUC5B MUC5AC
8 chronic ethmoiditis 10.2 MUC5B MUC5AC
9 chronic purulent otitis media 10.2 MUC5B MUC5AC
10 papillary conjunctivitis 10.2 MUC5AC CXCL8
11 suppurative otitis media 10.2 MUC5B MUC5AC
12 giant papillary conjunctivitis 10.2 MUC5AC CXCL8
13 anthracosis 10.2 MUC5B CXCL8
14 mycobacterium marinum 10.2 HMOX1 CXCL8
15 chronic conjunctivitis 10.2 MUC5AC CXCL8
16 blepharitis 10.2 MUC5AC CXCL8
17 granulomatous disease, chronic, autosomal recessive, 1 10.1 NOXO1 NOXA1
18 idiopathic interstitial pneumonia 10.1 MUC5B CXCL8
19 lacrimal apparatus disease 10.1 MUC5AC CXCL8
20 acute asthma 10.1 MUC5B MUC5AC CXCL8
21 middle ear disease 10.1 MUC5B MUC5AC CXCL8
22 phagocyte bactericidal dysfunction 10.1 NOXO1 NOXA1
23 vernal conjunctivitis 10.1 MUC5AC MUC3A
24 allergic conjunctivitis 10.1 MUC5AC CXCL8
25 bronchial disease 10.1 MUC5B MUC5AC CXCL8
26 otitis media 10.1 MUC5B MUC5AC CXCL8
27 ampulla of vater adenocarcinoma 10.1 MUC5AC MIR30D
28 retinal artery occlusion 10.0 HMOX1 CXCL8
29 conjunctival disease 10.0 MUC5AC CXCL8
30 lung cancer 10.0
31 adenocarcinoma 10.0
32 lung benign neoplasm 10.0
33 brain edema 10.0
34 rare tumor 10.0
35 pulmonary disease, chronic obstructive 10.0 MUC5AC HMOX1 CXCL8
36 pneumonia 10.0 MUC5B HMOX1 CXCL8
37 bronchiolo-alveolar adenocarcinoma 9.9 MUC5AC MUC3A
38 interstitial lung disease 2 9.9 MUC5B MUC5AC HMOX1 CXCL8
39 dry eye syndrome 9.9 MUC5AC CXCL8
40 asthma 9.8 MUC5B MUC5AC IRAK3 HMOX1 CXCL8
41 cystic fibrosis 9.6 MUC5B MUC5AC MUC3A HMOX1 CXCL8

Graphical network of the top 20 diseases related to Lung Mucoepidermoid Carcinoma:



Diseases related to Lung Mucoepidermoid Carcinoma

Symptoms & Phenotypes for Lung Mucoepidermoid Carcinoma

UMLS symptoms related to Lung Mucoepidermoid Carcinoma:


hemoptysis; wheezing

Drugs & Therapeutics for Lung Mucoepidermoid Carcinoma

Search Clinical Trials, NIH Clinical Center for Lung Mucoepidermoid Carcinoma

Genetic Tests for Lung Mucoepidermoid Carcinoma

Anatomical Context for Lung Mucoepidermoid Carcinoma

Organs/tissues related to Lung Mucoepidermoid Carcinoma:

MalaCards : Lung, Brain, Neutrophil

Publications for Lung Mucoepidermoid Carcinoma

Articles related to Lung Mucoepidermoid Carcinoma:

(show all 31)
# Title Authors PMID Year
1
Apatinib and fractionated stereotactic radiotherapy for the treatment of limited brain metastases from primary lung mucoepidermoid carcinoma: A case report. 62
33120847 2020
2
A unique case of mandibular metastasis from primary lung mucoepidermoid carcinoma. 62
31521497 2019
3
[A Pulmonary Mucoepidermoid Carcinoma with Anaplastic Lymphoma Kinase Fusion Responding to Alectinib Hydrochloride]. 62
31588102 2019
4
A Rare Case of Pulmonary Mucoepidermoid Carcinoma in an 81-Year-Old Male. 62
30555150 2018
5
[Clinical characteristics and prognostic analyses of 87 patients with pulmonary mucoepidermoid carcinoma]. 62
29936772 2018
6
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation. 62
29393460 2018
7
Lignans Isolated From Flower Buds of Magnolia fargesii Attenuate Airway Inflammation Induced by Cigarette Smoke in vitro and in vivo. 62
30258361 2018
8
Primary lung mucoepidermoid carcinoma: analysis of prognostic factors using surveillance, epidemiology and end results program. 62
26663856 2017
9
Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis. 62
28816646 2017
10
Nrf2-heme oxygenase-1 axis in mucoepidermoid carcinoma of the lung: Antitumoral effects associated with down-regulation of matrix metalloproteinases. 62
26393425 2015
11
Induction of MUC5AC mucin expression by histamine through the activation of its core promoter region. 62
25872410 2015
12
[Screening of citrullinated proteins in ten tumor cell lines]. 62
25975782 2015
13
Investigation by microarray analysis of effects of cigarette design characteristics on gene expression in human lung mucoepidermoid cancer cells NCI-H292 exposed to cigarette smoke. 62
25497788 2015
14
Brain metastasis from a lung mucoepidermoid carcinoma mimicking a brain abscess. 62
26167374 2015
15
Toxic effects of Microgramma vacciniifolia rhizome lectin on Artemia salina, human cells, and the schistosomiasis vector Biomphalaria glabrata. 62
24954527 2014
16
Mixed lung mucoepidermoid carcinoma and adenocarcinoma with identical mutations in an epidermal growth factor receptor gene. 62
25087791 2014
17
Hypoxia-mediated mechanism of MUC5AC production in human nasal epithelia and its implication in rhinosinusitis. 62
24840724 2014
18
Regulation and novel action of thymidine phosphorylase in non-small cell lung cancer: crosstalk with Nrf2 and HO-1. 62
24819505 2014
19
A heat-stable cytotoxic factor produced by Achromobacter xylosoxidans isolated from Brazilian patients with CF is associated with in vitro increased proinflammatory cytokines. 62
22440828 2012
20
FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells. 62
22447226 2012
21
L-carbocisteine reduces neutrophil elastase-induced mucin production. 62
19394453 2009
22
t(11;19)(q21;p12~p13.11) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma. 62
17618868 2007
23
Proteomic and transcriptomic analysis of interleukin-1beta treated lung carcinoma cell line. 62
14673796 2003
24
Simvastatin effects on a human lung carcinoma and cholesterol homeostasis of host and non-host mice. 62
11935385 2001
25
Lung epithelial H292 cells induce differentiation of immature human HMC-1 mast cells by interleukin-6 and stem cell factor. 62
10931117 2000
26
Effects of lovastatin on the fatty acid desaturation in a human lung mucoepidermoid carcinoma grown in nude mice. 62
9132162 1996
27
[Effect of dietary supplementation with gamma-linolenic acid on the growth of a human lung carcinoma implanted in nude mice]. 62
8731577 1995
28
Effects of an eicosapentaenoic and docosahexaenoic acid concentrate on a human lung carcinoma grown in nude mice. 62
1839563 1991
29
NCI-H292 as an alternative cell line for the isolation and propagation of the human paramyxoviruses. 62
2260924 1990
30
In vitro effect of eicosapentaenoic and docosahexaenoic acids on prostaglandin E2 synthesis in a human lung carcinoma. 62
2554913 1989
31
Microsomal fatty acid desaturation and elongation in a human lung carcinoma grown in nude mice. 62
3382413 1988

Variations for Lung Mucoepidermoid Carcinoma

Cosmic variations for Lung Mucoepidermoid Carcinoma:

8 (show top 50) (show all 1544)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM147933004 EGFR lung,NS,carcinoma,mucoepidermoid carcinoma c.*572T>A p.? 7:55191831-55191831 8
2 COSM111333055 EGFR lung,NS,carcinoma,mucoepidermoid carcinoma c.2447T>A p.L816Q 7:55191831-55191831 8
3 COSM86749037 EGFR lung,NS,carcinoma,mucoepidermoid carcinoma c.2582T>A p.L861Q 7:55191831-55191831 8
4 COSM111939295 EGFR lung,NS,carcinoma,mucoepidermoid carcinoma c.2447T>A p.L816Q 7:55191831-55191831 8
5 COSM102042323 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8009A>G p.? 16:72958974-72958974 6
6 COSM87291734 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
7 COSM102040476 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.-23-8037G>T p.? 16:72959002-72959002 6
8 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
9 COSM87290218 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
10 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
11 COSM126973051 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.770C>T p.P257L 11:102229729-102229729 6
12 COSM145028029 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1154C>T p.P385L 11:102229729-102229729 6
13 COSM128452039 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 6
14 COSM85237448 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1304C>T p.P435L 11:102229729-102229729 6
15 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 6
16 COSM127997731 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1256C>T p.P419L 11:102229729-102229729 6
17 COSM133274224 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1268C>T p.P423L 11:102229729-102229729 6
18 COSM90948266 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1202C>T p.P401L 11:102229729-102229729 6
19 COSM108017622 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 6
20 COSM95166535 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
21 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
22 COSM105839764 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1009A>C p.I337L 22:41653558-41653558 6
23 COSM106337415 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
24 COSM103711109 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1036A>C p.I346L 22:41653558-41653558 6
25 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 6
26 COSM134125623 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1114A>G p.M372V 19:43546970-43546970 6
27 COSM100781761 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.724A>T p.K242* 11:32392044-32392044 6
28 COSM111539040 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 6
29 COSM149728755 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
30 COSM130518653 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.673A>T p.K225* 11:32392044-32392044 6
31 COSM113475703 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
32 COSM111529696 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
33 COSM113484991 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
34 COSM147414475 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
35 COSM149739953 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
36 COSM148580942 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
37 COSM148593279 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
38 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
39 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
40 COSM147426277 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1309A>T p.K437* 11:32392044-32392044 6
41 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 6
42 COSM104050903 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 6
43 COSM105123686 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 6
44 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 6
45 COSM102763785 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.*288A>C p.? 12:48966259-48966259 6
46 COSM99767946 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
47 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
48 COSM121848752 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
49 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
50 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 6

Expression for Lung Mucoepidermoid Carcinoma

Search GEO for disease gene expression data for Lung Mucoepidermoid Carcinoma.

Pathways for Lung Mucoepidermoid Carcinoma

Pathways related to Lung Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.09 MUC5B MUC5AC MUC3A
2
Show member pathways
12.04 MUC5B MUC5AC MUC3A
3
Show member pathways
11.92 MUC5B MUC5AC CXCL8
4
Show member pathways
11.66 MUC5B MUC5AC MUC3A
5
Show member pathways
11.58 MUC5B MUC5AC IRAK3 HMOX1 CXCL8
6
Show member pathways
11.17 MUC5B MUC5AC MUC3A
7 11.02 HMOX1 CXCL8
8 10.93 MUC5B HMOX1 CXCL8
9 10.91 HMOX1 CXCL8
10 10.78 NOXO1 NOXA1
11
Show member pathways
10.75 NOXO1 NOXA1
12 10.54 HMOX1 CXCL8

GO Terms for Lung Mucoepidermoid Carcinoma

Cellular components related to Lung Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.43 MUC5B MUC5AC MUC3A
2 NADPH oxidase complex GO:0043020 8.92 NOXO1 NOXA1

Biological processes related to Lung Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 superoxide anion generation GO:0042554 9.56 NOXO1 NOXA1
2 superoxide metabolic process GO:0006801 9.33 NOXO1 NOXA1
3 regulation of hydrogen peroxide metabolic process GO:0010310 9.26 NOXO1 NOXA1
4 regulation of respiratory burst GO:0060263 8.92 NOXO1 NOXA1

Molecular functions related to Lung Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 superoxide-generating NADPH oxidase activator activity GO:0016176 8.92 NOXO1 NOXA1

Sources for Lung Mucoepidermoid Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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