Lung Papillary Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lung Papillary Adenocarcinoma

MalaCards integrated aliases for Lung Papillary Adenocarcinoma:

Name: Lung Papillary Adenocarcinoma ¹² ¹⁵

Papillary Lung Adenocarcinoma ¹⁷ ⁷⁴

Papillary Adenocarcinoma of the Lung ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5588

NCIt ⁵¹ C5650

EFO ¹⁷ EFO_1000046

UMLS ⁷⁴ C1335325

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Summaries for Lung Papillary Adenocarcinoma

Disease Ontology : ¹² A papillary adenocarcinoma that is located in the lung.

MalaCards based summary : Lung Papillary Adenocarcinoma, also known as papillary lung adenocarcinoma, is related to lung cancer susceptibility 3 and adenocarcinoma, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with Lung Papillary Adenocarcinoma is RRM1 (Ribonucleotide Reductase Catalytic Subunit M1), and among its related pathways/superpathways are Gastric cancer and Glioma. Affiliated tissues include lung, kidney and pancreas, and related phenotypes are integument and neoplasm

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Related Diseases for Lung Papillary Adenocarcinoma

Diseases related to Lung Papillary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)

#	Related Disease	Score	Top Affiliating Genes
1	lung cancer susceptibility 3	29.3	ALK ERCC1 NFE2L2 TP53
2	adenocarcinoma	10.1
3	papillary adenocarcinoma	10.1
4	parameningeal embryonal rhabdomyosarcoma	10.1	ALK TP53
5	primary peritoneal carcinoma	10.1	ERCC1 TP53
6	pleomorphic carcinoma	10.0	ALK TP53
7	autonomic nervous system neoplasm	10.0	ALK TP53
8	lung adenoid cystic carcinoma	10.0	ALK EML4
9	pneumothorax	9.9	ALK NFE2L2
10	peripheral nervous system neoplasm	9.9	ALK TP53
11	childhood kidney cell carcinoma	9.9	ALK EML4
12	histiocytoma	9.9	ALK TP53
13	in situ pulmonary adenocarcinoma	9.9	ALK EML4
14	autosomal genetic disease	9.9	ERCC1 TP53
15	bronchiolo-alveolar adenocarcinoma	9.9
16	renal cell carcinoma, papillary, 1	9.9	NFE2L2 TP53
17	differentiated thyroid carcinoma	9.9	ALK TP53
18	pancreas adenocarcinoma	9.9	ERCC1 RRM1 TP53
19	anemia, autoimmune hemolytic	9.9
20	hemolytic anemia	9.9
21	xeroderma pigmentosum, variant type	9.9	ERCC1 RRM1 TP53
22	inflammatory myofibroblastic tumor	9.7	ALK EML4 TP53
23	oral cavity cancer	9.7	ERCC1 TP53
24	respiratory system disease	9.7	ALK EML4 TP53
25	lung squamous cell carcinoma	9.6	ALK KEAP1 NFE2L2 TP53
26	respiratory system cancer	9.3	ALK EML4 ERCC1 RRM1 TP53
27	lung cancer	9.2	ALK EML4 ERCC1 RRM1 TP53

Graphical network of the top 20 diseases related to Lung Papillary Adenocarcinoma:

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Symptoms & Phenotypes for Lung Papillary Adenocarcinoma

UMLS symptoms related to Lung Papillary Adenocarcinoma:

fever, dyspnea, hemoptysis, coughing

MGI Mouse Phenotypes related to Lung Papillary Adenocarcinoma:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.35	ALK ERCC1 KEAP1 NFE2L2 TP53
2	neoplasm	MP:0002006	8.92	ALK ERCC1 NFE2L2 TP53

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Drugs & Therapeutics for Lung Papillary Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Lung Papillary Adenocarcinoma

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Genetic Tests for Lung Papillary Adenocarcinoma

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Anatomical Context for Lung Papillary Adenocarcinoma

MalaCards organs/tissues related to Lung Papillary Adenocarcinoma:

⁴²

Lung, Kidney, Pancreas, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Papillary Adenocarcinoma:

²⁰

The Lung

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Publications for Lung Papillary Adenocarcinoma

Articles related to Lung Papillary Adenocarcinoma:

#	Title	Authors	Year
1	Papillary lung adenocarcinoma with psammomatous calcifications. ( 30094154 )	Gupta A...Narwal P	2018
2	c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma. ( 27602772 )	Ciribilli Y...Borlak J	2016
3	Lung papillary adenocarcinoma complicated with paraneoplastic autoimmune hemolytic anemia: A case report. ( 26766978 )	Xing L...Shao Z	2014

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Genes for Lung Papillary Adenocarcinoma

Genes related to Lung Papillary Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	14.72	DISEASES inferred ¹⁵
2	KEAP1	Kelch Like ECH Associated Protein 1	Protein Coding	14.55	DISEASES inferred ¹⁵
3	TP53	Tumor Protein P53	Protein Coding	14.24	DISEASES inferred ¹⁵
4	NFE2L2	Nuclear Factor, Erythroid 2 Like 2	Protein Coding	14.23	DISEASES inferred ¹⁵
5	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	14.19	DISEASES inferred ¹⁵
6	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	13.71	DISEASES inferred ¹⁵
7	WDFY2	WD Repeat And FYVE Domain Containing 2	Protein Coding	4.83	DISEASES inferred ¹⁵
8	EML4	EMAP Like 4	Protein Coding	4.58	DISEASES inferred ¹⁵

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Variations for Lung Papillary Adenocarcinoma

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Expression for Lung Papillary Adenocarcinoma

Search GEO for disease gene expression data for Lung Papillary Adenocarcinoma.

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Pathways for Lung Papillary Adenocarcinoma

Pathways related to Lung Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.28	KEAP1 NFE2L2 TP53
2	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.23	ALK EML4 TP53
3	DNA Damage ⁴	11.97	ERCC1 RRM1 TP53
4	Pathways in cancer ³⁸	11.75	ALK EML4 KEAP1 NFE2L2 TP53
5	Platinum drug resistance ³⁸	11.27	ERCC1 TP53
6	Fluid shear stress and atherosclerosis ³⁸	11.27	KEAP1 NFE2L2 TP53
7	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.08	NFE2L2 TP53
8	Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling ¹	10.64	KEAP1 NFE2L2
9	Transcriptional activation by NRF2 ¹	10.33	KEAP1 NFE2L2

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GO Terms for Lung Papillary Adenocarcinoma

Cellular components related to Lung Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	9.17	EML4 ERCC1 KEAP1 NFE2L2 RRM1 TP53
2	transcription factor TFIID complex	GO:0005669	8.96	ERCC1 TP53

Biological processes related to Lung Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell proliferation	GO:0008283	9.5	ALK ERCC1 TP53
2	cellular response to drug	GO:0035690	9.37	NFE2L2 TP53
3	nucleotide-excision repair	GO:0006289	9.26	ERCC1 TP53
4	cellular response to glucose starvation	GO:0042149	9.16	NFE2L2 TP53
5	positive regulation of reactive oxygen species metabolic process	GO:2000379	8.96	NFE2L2 TP53
6	proteasomal ubiquitin-independent protein catabolic process	GO:0010499	8.62	KEAP1 NFE2L2

Molecular functions related to Lung Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.56	ALK KEAP1 RRM1 TP53
2	transcription factor binding	GO:0008134	9.33	KEAP1 NFE2L2 TP53
3	TFIID-class transcription factor complex binding	GO:0001094	8.96	ERCC1 TP53
4	disordered domain specific binding	GO:0097718	8.8	KEAP1 RRM1 TP53

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Sources for Lung Papillary Adenocarcinoma

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