Lung Pleomorphic Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lung Pleomorphic Carcinoma

MalaCards integrated aliases for Lung Pleomorphic Carcinoma:

Name: Lung Pleomorphic Carcinoma ¹¹ ¹⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0080899

NCIt ⁴⁹ C45542

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Summaries for Lung Pleomorphic Carcinoma

Disease Ontology: ¹¹ A pleomorphic carcinoma that is characterized by the presence of malignant glandular or squamous cells associated with malignant giant and spindle cells and that is located in the lung.

MalaCards based summary: Lung Pleomorphic Carcinoma is related to pleomorphic carcinoma and lipodystrophy, congenital generalized, type 3. An important gene associated with Lung Pleomorphic Carcinoma is CAV1 (Caveolin 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cytoskeletal Signaling. Affiliated tissues include lung, and related phenotypes are neoplasm and adipose tissue

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Related Diseases for Lung Pleomorphic Carcinoma

Diseases related to Lung Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)

#	Related Disease	Score	Top Affiliating Genes
1	pleomorphic carcinoma	10.2
2	lipodystrophy, congenital generalized, type 3	10.1	CAV2 CAV1
3	gallbladder papillary carcinoma	10.1	PDPN CEACAM5
4	colonic lymphangioma	10.1	PDPN CEACAM5
5	lymphangioma	10.1	PDPN CEACAM5
6	xanthogranulomatous cholecystitis	10.1	PDPN CEACAM5
7	lymphohistiocytoid mesothelioma	10.1	PDPN CEACAM5
8	lymphangitis	10.1	PDPN CEACAM5
9	gastric diffuse adenocarcinoma	10.0	PDPN CEACAM5
10	benign peritoneal mesothelioma	10.0	PDPN CEACAM5
11	rippling muscle disease 2	10.0	CAV2 CAV1
12	peritoneal mesothelioma	10.0	PDPN CEACAM5
13	gallbladder adenocarcinoma	10.0	PDPN CEACAM5
14	adenocarcinoma in situ	10.0	PDPN CEACAM5
15	benign mesothelioma	10.0	PDPN CEACAM5
16	glaucoma, normal tension	10.0	CAV2 CAV1
17	signet ring cell adenocarcinoma	10.0	PDPN CEACAM5
18	microinvasive gastric cancer	10.0	PDPN CEACAM5
19	isolated elevated serum creatine phosphokinase levels	10.0	CAV2 CAV1
20	intussusception	9.9
21	lung cancer susceptibility 3	9.9
22	cardiovascular organ benign neoplasm	9.9	PDPN CEACAM5
23	splenic tuberculosis	9.9	SLC29A1 CEACAM5
24	cystadenocarcinoma	9.8	PDPN CEACAM5
25	glaucoma, primary open angle	9.8	CAV2 CAV1

Graphical network of the top 20 diseases related to Lung Pleomorphic Carcinoma:

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Symptoms & Phenotypes for Lung Pleomorphic Carcinoma

MGI Mouse Phenotypes related to Lung Pleomorphic Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.26	CAV1 CAV2 CEACAM5 SLC3A2
2	adipose tissue	MP:0005375	8.92	CAV1 CAV2 CEACAM5 SLC29A1

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Drugs & Therapeutics for Lung Pleomorphic Carcinoma

Search Clinical Trials, NIH Clinical Center for Lung Pleomorphic Carcinoma

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Genetic Tests for Lung Pleomorphic Carcinoma

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Anatomical Context for Lung Pleomorphic Carcinoma

Organs/tissues related to Lung Pleomorphic Carcinoma:

FMA: Lung

MalaCards : Lung

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Publications for Lung Pleomorphic Carcinoma

Articles related to Lung Pleomorphic Carcinoma:

#	Title	Authors	PMID	Year
1	Argon plasma coagulation with atezolizumab and chemoradiation in lung pleomorphic cancer showed a remarkable response: Case report. ⁶²	Harada M...Koshimizu N	34032770	2021
2	Could Tumor Spread Through Air Spaces Identify Distinct Subgroup With Poor Prognosis in Lung Pleomorphic Carcinoma? ⁶²	Song T...Lin Y	31511154	2019
3	Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis. ⁶²	Chen D...Chen Y	30914285	2019
4	Spread Through Air Spaces (STAS): A New Pathologic Morphology in Lung Cancer. ⁶²	Ma K...Wang Q	30482593	2019
5	Tumor Spread Through Air Spaces Identifies a Distinct Subgroup With Poor Prognosis in Surgically Resected Lung Pleomorphic Carcinoma. ⁶²	Yokoyama S...Akagi Y	29932891	2018
6	Lung cancer mimicking lung abscess formation on CT images. ⁶²	Taira N...Ishikawa K	24949114	2014
7	Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine. ⁶²	Tamiya A...Kubo A	25400187	2014
8	Intussusception caused by intestinal metastasis from lung pleomorphic carcinoma. ⁶²	Lin MW...Chang YL	23903709	2014
9	Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case. ⁶²	Kato T...Kaji M	21626334	2011
10	[A long-surviving patient with lung pleomorphic carcinoma treated with postoperative carboplatin and paclitaxel combination chemotherapy]. ⁶²	Nakamura S...Shinomiya S	18633226	2008

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Genes for Lung Pleomorphic Carcinoma

Genes related to Lung Pleomorphic Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CAV1	Caveolin 1	Protein Coding	4.78	DISEASES inferred ¹⁴
2	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.43	DISEASES inferred ¹⁴
3	CAV2	Caveolin 2	Protein Coding	4.4	DISEASES inferred ¹⁴
4	PDPN	Podoplanin	Protein Coding	4.34	DISEASES inferred ¹⁴
5	EFHD2	EF-Hand Domain Family Member D2	Protein Coding	4.31	DISEASES inferred ¹⁴
6	SLC3A2	Solute Carrier Family 3 Member 2	Protein Coding	4.31	DISEASES inferred ¹⁴
7	SLC29A1	Solute Carrier Family 29 Member 1 (Augustine Blood Group)	Protein Coding	4.3	DISEASES inferred ¹⁴
8	DDIT4L	DNA Damage Inducible Transcript 4 Like	Protein Coding	4.29	DISEASES inferred ¹⁴

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Variations for Lung Pleomorphic Carcinoma

Cosmic variations for Lung Pleomorphic Carcinoma:

⁸ (show top 50) (show all 1809)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM144086938	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.4G>A	p.A2T	17:7675131-7675131	6
2	COSM106055701	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.797G>T	p.G266V	17:7673823-7673823	6
3	COSM144088893	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.362G>A	p.R121K	17:7673781-7673781	6
4	COSM142560384	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.616G>T	p.G206C	17:7674230-7674230	6
5	COSM144326948	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.596G>T	p.C199F	17:7674250-7674250	6
6	COSM122740379	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.77G>T	p.R26L	17:7675139-7675139	6
7	COSM106053269	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.733G>T	p.G245C	17:7674230-7674230	6
8	COSM122275322	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.245A>G	p.H82R	17:7674890-7674890	6
9	COSM93213412	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.524G>T	p.R175L	17:7675088-7675088	6
10	COSM87898463	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.733G>T	p.G245C	17:7674230-7674230	6
11	COSM122290671	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.-1G>T	p.?	17:7675216-7675216	6
12	COSM143171334	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.371G>A	p.R124H	17:7673772-7673772	6
13	COSM143373275	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.722G>A	p.R241K	17:7673781-7673781	6
14	COSM111758868	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.742C>T	p.R248W	17:7674221-7674221	6
15	COSM144013214	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.626A>G	p.Y209C	17:7674872-7674872	6
16	COSM144013467	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.700G>T	p.G234C	17:7674230-7674230	6
17	COSM142852638	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.713G>T	p.C238F	17:7674250-7674250	6
18	COSM142859154	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.524G>T	p.R175L	17:7675088-7675088	6
19	COSM143196700	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.278T>C	p.L93P	17:7674208-7674208	6
20	COSM93230640	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.755T>C	p.L252P	17:7674208-7674208	6
21	COSM105627435	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.473G>T	p.R158L	17:7675139-7675139	6
22	COSM142850679	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.848G>A	p.R283H	17:7673772-7673772	6
23	COSM145044486	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.407G>T	p.R136L	17:7675088-7675088	6
24	COSM144013676	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.709C>T	p.R237W	17:7674221-7674221	6
25	COSM122288333	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.452G>A	p.R151H	17:7673772-7673772	6
26	COSM144324889	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.731G>A	p.R244H	17:7673772-7673772	6
27	COSM121897862	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.317G>T	p.C106F	17:7674250-7674250	6
28	COSM105620390	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.733G>T	p.G245C	17:7674230-7674230	6
29	COSM142852494	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.396G>T	p.K132N	17:7675216-7675216	6
30	COSM143373581	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.680G>T	p.G227V	17:7673823-7673823	6
31	COSM144087169	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.256G>T	p.G86C	17:7674230-7674230	6
32	COSM144089037	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.320G>T	p.G107V	17:7673823-7673823	6
33	COSM144015650	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.806G>A	p.R269K	17:7673781-7673781	6
34	COSM122316951	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.359T>C	p.L120P	17:7674208-7674208	6
35	COSM143156901	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.256G>T	p.G86C	17:7674230-7674230	6
36	COSM144650743	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.364G>A	p.A122T	17:7675131-7675131	6
37	COSM143943533	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.4G>A	p.A2T	17:7675131-7675131	6
38	COSM143971019	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.47G>T	p.R16L	17:7675088-7675088	6
39	COSM87922049	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.713G>T	p.C238F	17:7674250-7674250	6
40	COSM144310285	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.616G>T	p.G206C	17:7674230-7674230	6
41	COSM143370705	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.542A>G	p.Y181C	17:7674872-7674872	6
42	COSM93183738	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.733G>T	p.G245C	17:7674230-7674230	6
43	COSM144102336	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.-82G>T	p.?	17:7675216-7675216	6
44	COSM111761445	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.797G>T	p.G266V	17:7673823-7673823	6
45	COSM144089819	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.164A>G	p.H55R	17:7674890-7674890	6
46	COSM87901231	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.797G>T	p.G266V	17:7673823-7673823	6
47	COSM112299047	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.755T>C	p.L252P	17:7674208-7674208	6
48	COSM144313682	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.524A>G	p.H175R	17:7674890-7674890	6
49	COSM144326678	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.279G>T	p.K93N	17:7675216-7675216	6
50	COSM143370970	TP53	lung,NS,carcinoma,pleomorphic carcinoma	c.616G>T	p.G206C	17:7674230-7674230	6

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Expression for Lung Pleomorphic Carcinoma

Search GEO for disease gene expression data for Lung Pleomorphic Carcinoma.

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Pathways for Lung Pleomorphic Carcinoma

Pathways related to Lung Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.68	SLC3A2 PDPN CEACAM5 CAV1
2	Cytoskeletal Signaling ³	11.92	PDPN CAV2 CAV1
3	RHOD GTPase cycle ⁶⁶ Show member pathways RHOF GTPase cycle ⁶⁶	11.35	EFHD2 CAV1
4	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	11.04	SLC3A2 CEACAM5 CAV1
5	Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF) ²² Show member pathways Endocytic Trafficking of EGFR ⁶⁴	10.7	CAV2 CAV1
6	Basigin interactions ⁶⁶ Show member pathways Defective SLC7A7 causes lysinuric protein intolerance (LPI) ⁶⁶	10.39	SLC3A2 CAV1

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GO Terms for Lung Pleomorphic Carcinoma

Cellular components related to Lung Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005887	10.13	CAV1 CAV2 CEACAM5 PDPN SLC29A1
2	plasma membrane	GO:0005886	10.13	CAV1 CAV2 CEACAM5 PDPN SLC29A1
3	apical plasma membrane	GO:0016324	9.92	SLC3A2 SLC29A1 PDPN CEACAM5
4	membrane raft	GO:0045121	9.76	PDPN EFHD2 CAV2 CAV1
5	acrosomal membrane	GO:0002080	9.67	CAV2 CAV1
6	basolateral plasma membrane	GO:0016323	9.56	SLC3A2 SLC29A1 PDPN CEACAM5
7	caveolar macromolecular signaling complex	GO:0002095	8.92	CAV2 CAV1

Biological processes related to Lung Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of cytosolic calcium ion concentration	GO:0051480	9.76	CAV2 CAV1
2	lactation	GO:0007595	9.73	SLC29A1 CAV1
3	negative regulation of endothelial cell proliferation	GO:0001937	9.71	CAV2 CAV1
4	endothelial cell proliferation	GO:0001935	9.67	CAV2 CAV1
5	amino acid transport	GO:0006865	9.65	SLC3A2 PDPN
6	negative regulation of anoikis	GO:2000811	9.62	CEACAM5 CAV1
7	basement membrane organization	GO:0071711	9.56	CAV2 CAV1
8	vesicle organization	GO:0016050	9.46	CAV2 CAV1
9	receptor-mediated endocytosis of virus by host cell	GO:0019065	9.26	CAV2 CAV1
10	caveola assembly	GO:0070836	8.92	CAV2 CAV1

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Sources for Lung Pleomorphic Carcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LNG117 MIFTS: 32	Lung Pleomorphic Carcinoma Categories: Cancer diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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