MCID: LNG117
MIFTS: 32

Lung Pleomorphic Carcinoma

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Lung Pleomorphic Carcinoma

MalaCards integrated aliases for Lung Pleomorphic Carcinoma:

Name: Lung Pleomorphic Carcinoma 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0080899
NCIt 49 C45542

Summaries for Lung Pleomorphic Carcinoma

Disease Ontology: 11 A pleomorphic carcinoma that is characterized by the presence of malignant glandular or squamous cells associated with malignant giant and spindle cells and that is located in the lung.

MalaCards based summary: Lung Pleomorphic Carcinoma is related to pleomorphic carcinoma and lipodystrophy, congenital generalized, type 3. An important gene associated with Lung Pleomorphic Carcinoma is CAV1 (Caveolin 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cytoskeletal Signaling. Affiliated tissues include lung, and related phenotypes are neoplasm and adipose tissue

Related Diseases for Lung Pleomorphic Carcinoma

Graphical network of the top 20 diseases related to Lung Pleomorphic Carcinoma:



Diseases related to Lung Pleomorphic Carcinoma

Symptoms & Phenotypes for Lung Pleomorphic Carcinoma

MGI Mouse Phenotypes related to Lung Pleomorphic Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 CAV1 CAV2 CEACAM5 SLC3A2
2 adipose tissue MP:0005375 8.92 CAV1 CAV2 CEACAM5 SLC29A1

Drugs & Therapeutics for Lung Pleomorphic Carcinoma

Search Clinical Trials, NIH Clinical Center for Lung Pleomorphic Carcinoma

Genetic Tests for Lung Pleomorphic Carcinoma

Anatomical Context for Lung Pleomorphic Carcinoma

Organs/tissues related to Lung Pleomorphic Carcinoma:

FMA: Lung
MalaCards : Lung

Publications for Lung Pleomorphic Carcinoma

Articles related to Lung Pleomorphic Carcinoma:

# Title Authors PMID Year
1
Argon plasma coagulation with atezolizumab and chemoradiation in lung pleomorphic cancer showed a remarkable response: Case report. 62
34032770 2021
2
Could Tumor Spread Through Air Spaces Identify Distinct Subgroup With Poor Prognosis in Lung Pleomorphic Carcinoma? 62
31511154 2019
3
Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis. 62
30914285 2019
4
Spread Through Air Spaces (STAS): A New Pathologic Morphology in Lung Cancer. 62
30482593 2019
5
Tumor Spread Through Air Spaces Identifies a Distinct Subgroup With Poor Prognosis in Surgically Resected Lung Pleomorphic Carcinoma. 62
29932891 2018
6
Lung cancer mimicking lung abscess formation on CT images. 62
24949114 2014
7
Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine. 62
25400187 2014
8
Intussusception caused by intestinal metastasis from lung pleomorphic carcinoma. 62
23903709 2014
9
Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case. 62
21626334 2011
10
[A long-surviving patient with lung pleomorphic carcinoma treated with postoperative carboplatin and paclitaxel combination chemotherapy]. 62
18633226 2008

Variations for Lung Pleomorphic Carcinoma

Cosmic variations for Lung Pleomorphic Carcinoma:

8 (show top 50) (show all 1809)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM144086938 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.4G>A p.A2T 17:7675131-7675131 6
2 COSM106055701 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.797G>T p.G266V 17:7673823-7673823 6
3 COSM144088893 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.362G>A p.R121K 17:7673781-7673781 6
4 COSM142560384 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.616G>T p.G206C 17:7674230-7674230 6
5 COSM144326948 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.596G>T p.C199F 17:7674250-7674250 6
6 COSM122740379 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.77G>T p.R26L 17:7675139-7675139 6
7 COSM106053269 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.733G>T p.G245C 17:7674230-7674230 6
8 COSM122275322 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.245A>G p.H82R 17:7674890-7674890 6
9 COSM93213412 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.524G>T p.R175L 17:7675088-7675088 6
10 COSM87898463 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.733G>T p.G245C 17:7674230-7674230 6
11 COSM122290671 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.-1G>T p.? 17:7675216-7675216 6
12 COSM143171334 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.371G>A p.R124H 17:7673772-7673772 6
13 COSM143373275 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.722G>A p.R241K 17:7673781-7673781 6
14 COSM111758868 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.742C>T p.R248W 17:7674221-7674221 6
15 COSM144013214 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.626A>G p.Y209C 17:7674872-7674872 6
16 COSM144013467 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.700G>T p.G234C 17:7674230-7674230 6
17 COSM142852638 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.713G>T p.C238F 17:7674250-7674250 6
18 COSM142859154 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.524G>T p.R175L 17:7675088-7675088 6
19 COSM143196700 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.278T>C p.L93P 17:7674208-7674208 6
20 COSM93230640 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.755T>C p.L252P 17:7674208-7674208 6
21 COSM105627435 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.473G>T p.R158L 17:7675139-7675139 6
22 COSM142850679 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.848G>A p.R283H 17:7673772-7673772 6
23 COSM145044486 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.407G>T p.R136L 17:7675088-7675088 6
24 COSM144013676 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.709C>T p.R237W 17:7674221-7674221 6
25 COSM122288333 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.452G>A p.R151H 17:7673772-7673772 6
26 COSM144324889 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.731G>A p.R244H 17:7673772-7673772 6
27 COSM121897862 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.317G>T p.C106F 17:7674250-7674250 6
28 COSM105620390 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.733G>T p.G245C 17:7674230-7674230 6
29 COSM142852494 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.396G>T p.K132N 17:7675216-7675216 6
30 COSM143373581 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.680G>T p.G227V 17:7673823-7673823 6
31 COSM144087169 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.256G>T p.G86C 17:7674230-7674230 6
32 COSM144089037 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.320G>T p.G107V 17:7673823-7673823 6
33 COSM144015650 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.806G>A p.R269K 17:7673781-7673781 6
34 COSM122316951 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.359T>C p.L120P 17:7674208-7674208 6
35 COSM143156901 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.256G>T p.G86C 17:7674230-7674230 6
36 COSM144650743 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.364G>A p.A122T 17:7675131-7675131 6
37 COSM143943533 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.4G>A p.A2T 17:7675131-7675131 6
38 COSM143971019 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.47G>T p.R16L 17:7675088-7675088 6
39 COSM87922049 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.713G>T p.C238F 17:7674250-7674250 6
40 COSM144310285 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.616G>T p.G206C 17:7674230-7674230 6
41 COSM143370705 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.542A>G p.Y181C 17:7674872-7674872 6
42 COSM93183738 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.733G>T p.G245C 17:7674230-7674230 6
43 COSM144102336 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.-82G>T p.? 17:7675216-7675216 6
44 COSM111761445 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.797G>T p.G266V 17:7673823-7673823 6
45 COSM144089819 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.164A>G p.H55R 17:7674890-7674890 6
46 COSM87901231 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.797G>T p.G266V 17:7673823-7673823 6
47 COSM112299047 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.755T>C p.L252P 17:7674208-7674208 6
48 COSM144313682 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.524A>G p.H175R 17:7674890-7674890 6
49 COSM144326678 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.279G>T p.K93N 17:7675216-7675216 6
50 COSM143370970 TP53 lung,NS,carcinoma,pleomorphic carcinoma c.616G>T p.G206C 17:7674230-7674230 6

Expression for Lung Pleomorphic Carcinoma

Search GEO for disease gene expression data for Lung Pleomorphic Carcinoma.

Pathways for Lung Pleomorphic Carcinoma

Pathways related to Lung Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 SLC3A2 PDPN CEACAM5 CAV1
2 11.92 PDPN CAV2 CAV1
3
Show member pathways
11.35 EFHD2 CAV1
4
Show member pathways
11.04 SLC3A2 CEACAM5 CAV1
5
Show member pathways
10.7 CAV2 CAV1
6
Show member pathways
10.39 SLC3A2 CAV1

GO Terms for Lung Pleomorphic Carcinoma

Cellular components related to Lung Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005887 10.13 CAV1 CAV2 CEACAM5 PDPN SLC29A1
2 plasma membrane GO:0005886 10.13 CAV1 CAV2 CEACAM5 PDPN SLC29A1
3 apical plasma membrane GO:0016324 9.92 SLC3A2 SLC29A1 PDPN CEACAM5
4 membrane raft GO:0045121 9.76 PDPN EFHD2 CAV2 CAV1
5 acrosomal membrane GO:0002080 9.67 CAV2 CAV1
6 basolateral plasma membrane GO:0016323 9.56 SLC3A2 SLC29A1 PDPN CEACAM5
7 caveolar macromolecular signaling complex GO:0002095 8.92 CAV2 CAV1

Biological processes related to Lung Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cytosolic calcium ion concentration GO:0051480 9.76 CAV2 CAV1
2 lactation GO:0007595 9.73 SLC29A1 CAV1
3 negative regulation of endothelial cell proliferation GO:0001937 9.71 CAV2 CAV1
4 endothelial cell proliferation GO:0001935 9.67 CAV2 CAV1
5 amino acid transport GO:0006865 9.65 SLC3A2 PDPN
6 negative regulation of anoikis GO:2000811 9.62 CEACAM5 CAV1
7 basement membrane organization GO:0071711 9.56 CAV2 CAV1
8 vesicle organization GO:0016050 9.46 CAV2 CAV1
9 receptor-mediated endocytosis of virus by host cell GO:0019065 9.26 CAV2 CAV1
10 caveola assembly GO:0070836 8.92 CAV2 CAV1

Sources for Lung Pleomorphic Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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