MCID: LNG037
MIFTS: 31

Lung Sarcoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Sarcoma

MalaCards integrated aliases for Lung Sarcoma:

Name: Lung Sarcoma 12 15 71
Pulmonary Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2784
NCIt 49 C4860
UMLS 71 C0598790

Summaries for Lung Sarcoma

Disease Ontology : 12 A lung cancer that is located in the lung and that arises from transformed cells of mesenchymal origin.

MalaCards based summary : Lung Sarcoma, also known as pulmonary sarcoma, is related to spindle cell sarcoma and sarcoma. An important gene associated with Lung Sarcoma is SSX2 (SSX Family Member 2), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drugs Sorafenib and Panobinostat have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Lung Sarcoma

Diseases related to Lung Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 30.3 SSX2 SSX1 SS18 CD34
2 sarcoma 30.3 SSX2 SSX1 SS18 SKI
3 lung leiomyosarcoma 29.7 CD34 CALB2
4 benign mesothelioma 29.7 CD34 CALB2
5 liposarcoma 29.5 TAF15 CD34 CALB2
6 hemangiopericytoma, malignant 29.4 SSX2 SSX1 SS18 CD34
7 neurilemmoma 29.3 CD34 CALB2
8 sarcoma, synovial 29.2 SSX2 SSX1 SS18 CD34 CALB2
9 spindle cell synovial sarcoma 29.2 SSX2 SSX1 SS18 CD34
10 biphasic synovial sarcoma 29.0 SSX2 SSX1 SS18 CALB2
11 monophasic synovial sarcoma 28.8 SSX2 SSX1 SS18 CD34 CALB2
12 esophagus sarcoma 10.3 SSX2 CD34
13 malignant mesenchymoma 10.2 SSX2 CD34
14 mesenchymoma 10.2 SSX2 CD34
15 extraosseous osteosarcoma 10.2 SSX1 CD34
16 congenital mesoblastic nephroma 10.2 SSX2 SSX1
17 bone angioendothelial sarcoma 10.2 SSX1 SS18
18 meninges sarcoma 10.2 SSX2 SS18
19 malignant glandular tumor of peripheral nerve sheath 10.2 SSX2 CALB2
20 myxoid liposarcoma of the ovary 10.1 CD34 CALB2
21 liver fibroma 10.1 SSX2 CALB2
22 liposarcoma of the ovary 10.1 CD34 CALB2
23 pacinian tumor 10.1 CD34 CALB2
24 spindle cell thymoma 10.1 CD34 CALB2
25 benign fibrous mesothelioma 10.1 CD34 CALB2
26 fibroma 10.1 CD34 CALB2
27 spermatic cord cancer 10.1 SSX2 SSX1 CD34
28 liver leiomyoma 10.1 CD34 CALB2
29 rhabdoid cancer 10.1 SSX2 SS18
30 testicular fibroma 10.1 CD34 CALB2
31 heart sarcoma 10.1 SSX2 SSX1 CD34
32 cystic lymphangioma 10.1 CD34 CALB2
33 lymphangioma 10.1 CD34 CALB2
34 heart cancer 10.0 CD34 CALB2
35 liver benign neoplasm 10.0 FRK CD34
36 well-differentiated liposarcoma 10.0 SS18 CD34
37 synovium neoplasm 10.0 SSX2 SSX1 SS18
38 kidney sarcoma 10.0 SSX2 SSX1 SS18
39 glomus tumor 10.0 CD34 CALB2
40 cellular myxoid liposarcoma 10.0 SSX2 SSX1 SS18
41 connective tissue benign neoplasm 10.0 CD34 CALB2
42 epithelioid malignant peripheral nerve sheath tumor 10.0 SSX2 SS18 CD34
43 hemangioendothelioma 10.0
44 mesenchymal cell neoplasm 10.0 SSX2 SS18 CD34
45 rhabdomyosarcoma 2 10.0 SSX2 SSX1 SS18
46 cellular schwannoma 10.0 SSX1 SS18 CD34
47 pericardium disease 9.9 CD34 CALB2
48 retroperitoneal sarcoma 9.9 SSX2 CD34 CALB2
49 leiomyosarcoma 9.9
50 spindle cell carcinoma 9.9

Graphical network of the top 20 diseases related to Lung Sarcoma:



Diseases related to Lung Sarcoma

Symptoms & Phenotypes for Lung Sarcoma

GenomeRNAi Phenotypes related to Lung Sarcoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 SSX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.64 SSX1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.64 SKI
4 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.64 SSX1 SSX2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.64 SKI
6 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.64 SSX2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.64 SKI
8 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.64 SKI
9 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.64 SSX1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.64 SSX2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.64 SKI
12 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.64 SSX1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 SSX1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.64 SKI
15 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.64 SSX2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.64 SKI SSX1 SSX2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.64 SSX2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.64 SKI

Drugs & Therapeutics for Lung Sarcoma

Drugs for Lung Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239 406563
2
Panobinostat Approved, Investigational Phase 1 404950-80-7 6918837
3
Sirolimus Approved, Investigational Phase 1 53123-88-9 5284616 6436030 46835353
4
Everolimus Approved Phase 1 159351-69-6 6442177 70789204
5
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
6
Vinorelbine Approved, Investigational Phase 1 71486-22-1 60780 44424639
7
Mifepristone Approved, Investigational Phase 1 84371-65-3 55245
8
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
9
Modafinil Approved, Investigational Phase 1 68693-11-8 4236
10
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
11 Protein Kinase Inhibitors Phase 1
12 Histone Deacetylase Inhibitors Phase 1
13 Immunologic Factors Phase 1
14 Anti-Infective Agents Phase 1
15 Antibiotics, Antitubercular Phase 1
16 Anti-Bacterial Agents Phase 1
17 Antimitotic Agents Phase 1
18 Antifungal Agents Phase 1
19 Immunosuppressive Agents Phase 1
20 Contraceptives, Postcoital Phase 1
21 Contraceptive Agents Phase 1
22 Hormone Antagonists Phase 1
23 Contraceptives, Oral Phase 1
24 Luteolytic Agents Phase 1
25 Hormones Phase 1
26 Vaccines Phase 1
27 Cytochrome P-450 CYP3A Inducers Phase 1
28 Liver Extracts Phase 1
29 Central Nervous System Stimulants Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Intravenous REOLYSIN® (Wild-Type Reovirus) in the Treatment of Patients With Bone and Soft Tissue Sarcomas Metastatic to the Lung Completed NCT00503295 Phase 2
2 A Phase I Safety and Tolerability Study of LBH589 in Combination With Sorafenib in Patients With Advanced Renal Cell Carcinoma, Soft Tissue Sarcoma, and Non-small Cell Lung Carcinoma (NSCLC) of Non-squamous Histologies. Completed NCT01005797 Phase 1 Panobinostat (LBH589), Sorafenib
3 Phase I Clinical Trial of Temsirolimus and Vinorelbine in Advanced Solid Tumors. Completed NCT01155258 Phase 1 temsirolimus;vinorelbine ditartrate
4 Phase 1 Study of Mifepristone in Combination With Eribulin in Patients With Locally Advanced/Metastatic Breast or Other Specified Solid Tumors, With a Dose Expansion Cohort in Patients With Triple Negative Breast Cancer. Completed NCT02014337 Phase 1 Mifepristone and Eribulin in combination
5 Phase I Trial of Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Vaccine for Advanced Cancer Completed NCT01061840 Phase 1
6 Phase I Study of Targeted Lung Chemotherapy in the Treatment of Metastatic Tumors Active, not recruiting NCT01014598 Phase 1 Cisplatin

Search NIH Clinical Center for Lung Sarcoma

Genetic Tests for Lung Sarcoma

Anatomical Context for Lung Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Sarcoma:

19
Lung

MalaCards organs/tissues related to Lung Sarcoma:

40
Lung, Heart, Liver, Bone, Breast, Kidney, Ovary

Publications for Lung Sarcoma

Articles related to Lung Sarcoma:

(show top 50) (show all 165)
# Title Authors PMID Year
1
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a case report and review of the literature. 61
32039736 2020
2
Gross tumor volume segmentation for head and neck cancer radiotherapy using deep dense multi-modality network. 61
31514173 2019
3
Surgical Outcomes and Risk Analysis of Primary Pulmonary Sarcoma. 61
31499540 2019
4
Primary pulmonary sarcoma - treatment outcomes depending on the different types of radical operation. 61
31043968 2019
5
Surgical treatment of primary pulmonary sarcoma disseminated to both pulmonary arteries using composite pulmonary trunk and bifurcation of abdominal aorta allograft. 61
30647750 2018
6
Primary pulmonary sarcoma - long-term treatment outcomes and prognostic factors. 61
30310394 2018
7
TTB2 induces apoptosis in Ewing sarcoma cells. 61
30116354 2018
8
Use of Radiation Therapy Within the Last Year of Life Among Cancer Patients. 61
29487025 2018
9
MicroRNA-associated carcinogenesis in lung carcinoma. 61
29516903 2018
10
[Primary pulmonary sarcoma in a patient with pulmonary fibrosis and emphysema]. 61
28571658 2017
11
Pulmonary metastasectomy for sarcoma-Essen experience. 61
29119015 2017
12
Primary Pulmonary Myxoid Sarcoma: A Newly Described Entity-Report of a Case and Review of the Literature. 61
28449608 2017
13
A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors. 61
28881739 2017
14
The Use of Cardiac Resynchronization Therapy in Cancer Patients with Heart Failure. 61
29962508 2017
15
Primary lung sarcoma treated with stereotactic ablative radiotherapy: a case report. 61
28740403 2017
16
Diagnosis of a rare primary pulmonary synovial sarcoma with endobronchial ultrasound-guided transbronchial needle aspiration. 61
27755806 2016
17
[Interventional Bronchoscopy for the Treatment of Pulmonary Sarcoma]. 61
27666549 2016
18
Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy. 61
26831661 2016
19
An example of difficulty in diagnosising and treating lung sarcoma. 61
25900706 2016
20
Hemoptysis in a patient with multifocal primary pulmonary angiosarcoma. 61
27672071 2016
21
Primary pulmonary synovial sarcoma: A case report and review of literature. 61
26958527 2016
22
Single-port video-assisted thoracoscopic pulmonary segmentectomy: a report on 30 cases†. 61
26612717 2016
23
High-grade primary myxoid lung sarcoma presenting as recurrent hemorrhagic pleural effusions in a young woman. 61
27489706 2015
24
Radiation Therapy-Induced Cardiovascular Disease Treated by a Percutaneous Approach. 61
26064696 2015
25
Antitumor and Immunomodulating Activities of Exopolysaccharide Produced by Big Cup Culinary- Medicinal Mushroom Clitocybe maxima (Higher Basidiomycetes) in Liquid Submerged Culture. 61
26756301 2015
26
Bilateral anterior sternothoracotomy (clamshell incision): a suitable alternative for bilateral lung sarcoma metastasis in children. 61
25064077 2014
27
Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model. 61
24836648 2014
28
Incidence of pulmonary non-epithelial tumors: 18 years' experience at a single institute. 61
24405941 2014
29
Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma. 61
24507991 2014
30
Malignant fibrous histiocytoma presenting with complete opacification of the hemithorax: A case report. 61
25437664 2014
31
A case of pulmonary sarcoma with significant extension into the right lung. 61
25477969 2014
32
Therapeutic bronchoscopy followed by lobectomy for pulmonary sarcoma. 61
23857209 2013
33
[Progredient "pulmonary thromboembolism" in spite of sufficient anticoagulant therapy?]. 61
23512363 2013
34
An analysis of patient characteristics and clinical outcomes in primary pulmonary sarcoma. 61
23263688 2013
35
Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. 61
24267748 2013
36
Reliability of oral examinations: Radiation oncology certifying examination. 61
24674266 2013
37
Primary pulmonary sarcoma metastasising to the skin during pregnancy. 61
23866489 2012
38
[Analysis of 19 cases of primary pulmonary sarcoma]. 61
22681925 2012
39
Metastatic atrial sarcoma extending from the lung into the left atrium via a pulmonary vein. 61
22826652 2012
40
Relapsed pulmonary sarcoma presenting as congestive heart failure. 61
21509609 2011
41
Growth patterns of lung metastases from sarcomas. 61
21732122 2011
42
P-glycoprotein modulation by valspodar and cyclosporin does not increase tumor uptake of doxorubicin administered via isolated lung perfusion to rats bearing sarcoma lung metastases. 61
21737631 2011
43
Dedifferentiated chondrosarcoma of the lung: report of a case. 61
21264763 2011
44
Biomonitoring and biomarkers of organophosphate pesticides exposure - state of the art. 61
22216802 2011
45
[Primary pulmonary sarcoma-a study of 8 cases]. 61
20450547 2010
46
A rare reason for pulmonary hypertension: primary sarcoma of the pulmonary artery. 61
20150036 2010
47
Primary lung sarcoma. 61
19892455 2010
48
A 74-year-old man with an enlarging pleural-based mass that was not a mesothelioma. 61
19670125 2009
49
Clinical spectrum of pulmonary inflammatory myofibroblastic tumor. 61
18483076 2008
50
[Primary pleomorphic sarcoma of the lung]. 61
18622530 2008

Variations for Lung Sarcoma

Expression for Lung Sarcoma

Search GEO for disease gene expression data for Lung Sarcoma.

Pathways for Lung Sarcoma

Pathways related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.19 TAF15 SSX2 SSX1 SS18

GO Terms for Lung Sarcoma

Biological processes related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell motility GO:0048870 8.62 SKI CD34

Sources for Lung Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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