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MCID: LNG037
MIFTS: 35

Lung Sarcoma

Categories: Cancer diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lung Sarcoma

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MalaCards integrated aliases for Lung Sarcoma:

Name: Lung Sarcoma 12 15 72
Pulmonary Sarcoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2784
NCIt 50 C4860
UMLS 72 C0598790
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Summaries for Lung Sarcoma

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Disease Ontology : 12 A lung cancer that is located in the lung and that arises from transformed cells of mesenchymal origin.

MalaCards based summary : Lung Sarcoma, also known as pulmonary sarcoma, is related to sarcoma and idiopathic interstitial pneumonia. An important gene associated with Lung Sarcoma is SKI (SKI Proto-Oncogene), and among its related pathways/superpathways are Phagosome and Diseases of metabolism. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and liver.

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Related Diseases for Lung Sarcoma

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Diseases related to Lung Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 sarcoma 29.5 SKI EWSR1 CHEK2
2 idiopathic interstitial pneumonia 29.3 SFTPA2 SFTPA1
3 pulmonary fibrosis 29.0 SFTPA2 SFTPA1
4 spindle cell sarcoma 10.4
5 sarcoma, synovial 10.1
6 fibrosarcoma 10.1
7 hemangioendothelioma 10.0
8 leiomyosarcoma 9.9
9 acute interstitial pneumonia 9.9 SFTPA2 SFTPA1
10 neurilemmoma 9.9
11 spindle cell carcinoma 9.9
12 splenic artery aneurysm 9.9 SFTPA2 SFTPA1
13 hemangiopericytoma, malignant 9.8
14 angiosarcoma 9.8
15 liposarcoma 9.8
16 pleural empyema 9.8
17 monophasic synovial sarcoma 9.8
18 bronchitis 9.8
19 thymus adenocarcinoma 9.8 SFTPA2 SFTPA1
20 neutrophilia, hereditary 9.7
21 neutropenia 9.7
22 malignant fibroxanthoma 9.7
23 lymphangiosarcoma 9.7
24 rhabdomyosarcoma 9.7
25 histiocytoma 9.7
26 carcinosarcoma 9.7
27 fibrous histiocytoma 9.7
28 embryoma 9.7
29 lung leiomyosarcoma 9.7
30 embryonal sarcoma 9.7
31 pulmonary sequestration 9.7
32 soft tissue sarcoma 9.7
33 undifferentiated pleomorphic sarcoma 9.7
34 fibrosis of extraocular muscles, congenital, 1 9.7
35 mesothelioma, malignant 9.7
36 neurofibromatosis, type iv, of riccardi 9.7
37 asbestosis 9.7
38 silicosis 9.7
39 respiratory failure 9.7
40 heart disease 9.7
41 benign mesothelioma 9.7
42 pulmonary tuberculosis 9.7
43 adenocarcinoma 9.7
44 fibrous synovial sarcoma 9.7
45 spindle cell synovial sarcoma 9.7
46 biphasic synovial sarcoma 9.7
47 malignant peripheral nerve sheath tumor 9.7
48 congestive heart failure 9.7
49 conjunctivitis 9.7
50 hypereosinophilic syndrome 9.7

Graphical network of the top 20 diseases related to Lung Sarcoma:



Diseases related to Lung Sarcoma
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Symptoms & Phenotypes for Lung Sarcoma

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Drugs & Therapeutics for Lung Sarcoma

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Drugs for Lung Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1, Phase 2
2 Immunoglobulins Phase 1, Phase 2
3
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239 406563
4
Panobinostat Approved, Investigational Phase 1 404950-80-7 6918837
5
Sirolimus Approved, Investigational Phase 1 53123-88-9 6436030 5284616 46835353
6
Vinorelbine Approved, Investigational Phase 1 71486-22-1 60780 44424639
7
Everolimus Approved Phase 1 159351-69-6 6442177 70789204
8
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
9
Mifepristone Approved, Investigational Phase 1 84371-65-3 55245
10
Sargramostim Approved, Investigational Phase 1 83869-56-1, 123774-72-1
11
Modafinil Approved, Investigational Phase 1 68693-11-8 4236
12
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
13 Protein Kinase Inhibitors Phase 1
14 Histone Deacetylase Inhibitors Phase 1
15 Antineoplastic Agents, Phytogenic Phase 1
16 Antifungal Agents Phase 1
17 Tubulin Modulators Phase 1
18 Anti-Bacterial Agents Phase 1
19 Anti-Infective Agents Phase 1
20 Immunosuppressive Agents Phase 1
21 Antibiotics, Antitubercular Phase 1
22 Antimitotic Agents Phase 1
23 Immunologic Factors Phase 1
24 Contraceptives, Oral Phase 1
25 Contraceptives, Postcoital Phase 1
26 Contraceptive Agents Phase 1
27 Luteolytic Agents Phase 1
28 Hormones Phase 1
29 Hormone Antagonists Phase 1
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
31 Cytochrome P-450 CYP3A Inducers Phase 1
32 Central Nervous System Stimulants Phase 1
33 Cytochrome P-450 Enzyme Inducers Phase 1
34 Vaccines Phase 1
35 Wakefulness-Promoting Agents Phase 1
36 Liver Extracts Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Intravenous REOLYSIN® (Wild-Type Reovirus) in the Treatment of Patients With Bone and Soft Tissue Sarcomas Metastatic to the Lung Completed NCT00503295 Phase 2
2 A Phase 1/2 Dose Escalation and Dose Expansion Study of BA3021 in Patients With Advanced Solid Tumors Recruiting NCT03504488 Phase 1, Phase 2
3 A Phase I Safety and Tolerability Study of LBH589 in Combination With Sorafenib in Patients With Advanced Renal Cell Carcinoma, Soft Tissue Sarcoma, and Non-small Cell Lung Carcinoma (NSCLC) of Non-squamous Histologies. Completed NCT01005797 Phase 1 Panobinostat (LBH589), Sorafenib
4 Phase I Clinical Trial of Temsirolimus and Vinorelbine in Advanced Solid Tumors. Completed NCT01155258 Phase 1 temsirolimus;vinorelbine ditartrate
5 Phase 1 Study of Mifepristone in Combination With Eribulin in Patients With Locally Advanced/Metastatic Breast or Other Specified Solid Tumors, With a Dose Expansion Cohort in Patients With Triple Negative Breast Cancer. Completed NCT02014337 Phase 1 Mifepristone and Eribulin in combination
6 Phase I Trial of Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Vaccine for Advanced Cancer Completed NCT01061840 Phase 1
7 Phase I Study of Targeted Lung Chemotherapy in the Treatment of Metastatic Tumors Active, not recruiting NCT01014598 Phase 1 Cisplatin

Search NIH Clinical Center for Lung Sarcoma

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Genetic Tests for Lung Sarcoma

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Anatomical Context for Lung Sarcoma

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MalaCards organs/tissues related to Lung Sarcoma:

41
Lung, Breast, Liver, Bone, Heart, Colon, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Sarcoma:

19
Lung
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Publications for Lung Sarcoma

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Articles related to Lung Sarcoma:

(show top 50) (show all 162)
# Title Authors PMID Year
1
Primary pulmonary sarcoma - treatment outcomes depending on the different types of radical operation. 38
31043968 2019
2
Surgical treatment of primary pulmonary sarcoma disseminated to both pulmonary arteries using composite pulmonary trunk and bifurcation of abdominal aorta allograft. 38
30647750 2018
3
Primary pulmonary sarcoma - long-term treatment outcomes and prognostic factors. 38
30310394 2018
4
TTB2 induces apoptosis in Ewing sarcoma cells. 38
30116354 2018
5
Use of Radiation Therapy Within the Last Year of Life Among Cancer Patients. 38
29487025 2018
6
MicroRNA-associated carcinogenesis in lung carcinoma. 38
29516903 2018
7
[Primary pulmonary sarcoma in a patient with pulmonary fibrosis and emphysema]. 38
28571658 2017
8
Pulmonary metastasectomy for sarcoma-Essen experience. 38
29119015 2017
9
Primary Pulmonary Myxoid Sarcoma: A Newly Described Entity-Report of a Case and Review of the Literature. 38
28449608 2017
10
A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors. 38
28881739 2017
11
The Use of Cardiac Resynchronization Therapy in Cancer Patients with Heart Failure. 38
29962508 2017
12
Primary lung sarcoma treated with stereotactic ablative radiotherapy: a case report. 38
28740403 2017
13
Diagnosis of a rare primary pulmonary synovial sarcoma with endobronchial ultrasound-guided transbronchial needle aspiration. 38
27755806 2016
14
[Interventional Bronchoscopy for the Treatment of Pulmonary Sarcoma]. 38
27666549 2016
15
Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy. 38
26831661 2016
16
An example of difficulty in diagnosising and treating lung sarcoma. 38
25900706 2016
17
Hemoptysis in a patient with multifocal primary pulmonary angiosarcoma. 38
27672071 2016
18
Primary pulmonary synovial sarcoma: A case report and review of literature. 38
26958527 2016
19
Single-port video-assisted thoracoscopic pulmonary segmentectomy: a report on 30 cases†. 38
26612717 2016
20
High-grade primary myxoid lung sarcoma presenting as recurrent hemorrhagic pleural effusions in a young woman. 38
27489706 2015
21
Radiation Therapy-Induced Cardiovascular Disease Treated by a Percutaneous Approach. 38
26064696 2015
22
Antitumor and Immunomodulating Activities of Exopolysaccharide Produced by Big Cup Culinary- Medicinal Mushroom Clitocybe maxima (Higher Basidiomycetes) in Liquid Submerged Culture. 38
26756301 2015
23
Bilateral anterior sternothoracotomy (clamshell incision): a suitable alternative for bilateral lung sarcoma metastasis in children. 38
25064077 2014
24
Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model. 38
24836648 2014
25
Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma. 38
24507991 2014
26
Incidence of pulmonary non-epithelial tumors: 18 years' experience at a single institute. 38
24405941 2014
27
A case of pulmonary sarcoma with significant extension into the right lung. 38
25477969 2014
28
Malignant fibrous histiocytoma presenting with complete opacification of the hemithorax: A case report. 38
25437664 2014
29
Therapeutic bronchoscopy followed by lobectomy for pulmonary sarcoma. 38
23857209 2013
30
[Progredient "pulmonary thromboembolism" in spite of sufficient anticoagulant therapy?]. 38
23512363 2013
31
An analysis of patient characteristics and clinical outcomes in primary pulmonary sarcoma. 38
23263688 2013
32
Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. 38
24267748 2013
33
Reliability of oral examinations: Radiation oncology certifying examination. 38
24674266 2013
34
Primary pulmonary sarcoma metastasising to the skin during pregnancy. 38
23866489 2012
35
[Analysis of 19 cases of primary pulmonary sarcoma]. 38
22681925 2012
36
Metastatic atrial sarcoma extending from the lung into the left atrium via a pulmonary vein. 38
22826652 2012
37
Relapsed pulmonary sarcoma presenting as congestive heart failure. 38
21509609 2011
38
Growth patterns of lung metastases from sarcomas. 38
21732122 2011
39
P-glycoprotein modulation by valspodar and cyclosporin does not increase tumor uptake of doxorubicin administered via isolated lung perfusion to rats bearing sarcoma lung metastases. 38
21737631 2011
40
Dedifferentiated chondrosarcoma of the lung: report of a case. 38
21264763 2011
41
Biomonitoring and biomarkers of organophosphate pesticides exposure - state of the art. 38
22216802 2011
42
[Primary pulmonary sarcoma-a study of 8 cases]. 38
20450547 2010
43
A rare reason for pulmonary hypertension: primary sarcoma of the pulmonary artery. 38
20150036 2010
44
Primary lung sarcoma. 38
19892455 2010
45
A 74-year-old man with an enlarging pleural-based mass that was not a mesothelioma. 38
19670125 2009
46
Clinical spectrum of pulmonary inflammatory myofibroblastic tumor. 38
18483076 2008
47
[Primary pleomorphic sarcoma of the lung]. 38
18622530 2008
48
Intimal pulmonary artery sarcoma presenting as dyspnea: case report. 38
17603895 2007
49
Pulmonary leiomyosarcoma presenting as a pancoast tumor. 38
17673374 2007
50
Surgical experience for the pulmonary artery sarcoma. 38
17126101 2006
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Variations for Lung Sarcoma

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Expression for Lung Sarcoma

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Search GEO for disease gene expression data for Lung Sarcoma.
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Pathways for Lung Sarcoma

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Pathways related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Phagosome 37
11.59 SFTPA2 SFTPA1
2
Diseases of metabolism 66
Show member pathways
 11.34 SFTPA2 SFTPA1
3
Pertussis 37
11.2 SFTPA2 SFTPA1
4
Lung fibrosis 1
11.06 SFTPA2 SFTPA1
5
FOXA1 transcription factor network 1
Show member pathways
 10.82 SFTPA2 SFTPA1
6
Surfactant metabolism 66
Show member pathways
 10.59 SFTPA2 SFTPA1
7
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) 66
Show member pathways
 10.02 SFTPA2 SFTPA1
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GO Terms for Lung Sarcoma

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Cellular components related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 9.37 SKI CHEK2
2 collagen trimer GO:0005581 9.32 SFTPA2 SFTPA1
3 rough endoplasmic reticulum GO:0005791 9.26 SFTPA2 SFTPA1
4 multivesicular body GO:0005771 9.16 SFTPA2 SFTPA1
5 clathrin-coated endocytic vesicle GO:0045334 8.96 SFTPA2 SFTPA1
6 lamellar body GO:0042599 8.62 SFTPA2 SFTPA1

Biological processes related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to drug GO:0035690 9.37 NME1 CHEK2
2 toll-like receptor signaling pathway GO:0002224 9.32 SFTPA2 SFTPA1
3 positive regulation of phagocytosis GO:0050766 9.26 SFTPA2 SFTPA1
4 respiratory gaseous exchange GO:0007585 9.16 SFTPA2 SFTPA1
5 positive regulation of DNA binding GO:0043388 8.96 SKI NME1
6 surfactant homeostasis GO:0043129 8.62 SFTPA2 SFTPA1

Molecular functions related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 SFTPA2 SFTPA1
2 monosaccharide binding GO:0048029 8.62 SFTPA2 SFTPA1
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Sources for Lung Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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