MCID: LNG037
MIFTS: 31

Lung Sarcoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Sarcoma

MalaCards integrated aliases for Lung Sarcoma:

Name: Lung Sarcoma 12 15 73
Pulmonary Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2784
NCIt 50 C4860
UMLS 73 C0598790

Summaries for Lung Sarcoma

Disease Ontology : 12 A lung cancer that is located in the lung and that arises from transformed cells of mesenchymal origin.

MalaCards based summary : Lung Sarcoma, also known as pulmonary sarcoma, is related to sarcoma and acute interstitial pneumonia. An important gene associated with Lung Sarcoma is SKI (SKI Proto-Oncogene), and among its related pathways/superpathways are Phagosome and Diseases of metabolism. Affiliated tissues include lung, colon and neutrophil, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Lung Sarcoma

Graphical network of the top 20 diseases related to Lung Sarcoma:



Diseases related to Lung Sarcoma

Symptoms & Phenotypes for Lung Sarcoma

GenomeRNAi Phenotypes related to Lung Sarcoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.75 SALL1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.75 SALL1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.75 NME1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.75 NME1 SALL1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.75 SKI
6 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.75 SKI
7 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.75 NME1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.75 SALL1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.75 SKI
10 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.75 SKI
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.75 SKI
12 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.75 NME1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.75 SALL1 SKI
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.75 NME1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.75 SALL1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.75 SKI
17 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.75 SALL1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.75 NME1

Drugs & Therapeutics for Lung Sarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 BT1718 in Patients With Advanced Solid Tumours. Recruiting NCT03486730 Phase 1 BT1718

Search NIH Clinical Center for Lung Sarcoma

Genetic Tests for Lung Sarcoma

Anatomical Context for Lung Sarcoma

MalaCards organs/tissues related to Lung Sarcoma:

41
Lung, Colon, Neutrophil, Heart, Thymus, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Sarcoma:

19
The Lung

Publications for Lung Sarcoma

Articles related to Lung Sarcoma:

(show all 31)
# Title Authors Year
1
Primary pulmonary sarcoma - long-term treatment outcomes and prognostic factors. ( 30310394 )
2018
2
Primary lung sarcoma treated with stereotactic ablative radiotherapy: a case report. ( 28740403 )
2017
3
Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy. ( 26831661 )
2016
4
High-grade primary myxoid lung sarcoma presenting as recurrent hemorrhagic pleural effusions in a young woman. ( 27489706 )
2015
5
An example of difficulty in diagnosising and treating lung sarcoma. ( 25900706 )
2015
6
Bilateral anterior sternothoracotomy (clamshell incision): a suitable alternative for bilateral lung sarcoma metastasis in children. ( 25064077 )
2014
7
A case of pulmonary sarcoma with significant extension into the right lung. ( 25477969 )
2014
8
Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. ( 24267748 )
2013
9
An analysis of patient characteristics and clinical outcomes in primary pulmonary sarcoma. ( 23263688 )
2013
10
Therapeutic bronchoscopy followed by lobectomy for pulmonary sarcoma. ( 23857209 )
2013
11
Primary pulmonary sarcoma metastasising to the skin during pregnancy. ( 23866489 )
2012
12
Primary lung sarcoma. ( 19892455 )
2010
13
Intense paraneoplastic neutrophilic leukemoid reaction related to a G-CSF-secreting lung sarcoma. ( 16247754 )
2005
14
Pulmonary sarcoma complicated with neurofibromatosis type 1 (NF1). ( 12680156 )
2003
15
Hypertrophic osteopathy secondary to pulmonary sarcoma in a cat. ( 19379184 )
2003
16
Technique and results of hyperthermic (41 degrees C) isolated lung perfusion with high-doses of cisplatin for the treatment of surgically relapsing or unresectable lung sarcoma metastasis. ( 12103371 )
2002
17
Relationship between the concentration of CDDP in tumor and tumor size after isolated lung perfusion treatment experimental study on a solitary pulmonary sarcoma model in rats. ( 11088051 )
2000
18
Primary pulmonary sarcoma: a clinicopathologic study of 26 cases. ( 10619264 )
1999
19
Experimental pulmonary sarcoma metastases in athymic nude mice. ( 9209524 )
1997
20
Isolated lung perfusion with melphalan for the treatment of metastatic pulmonary sarcoma. ( 8975846 )
1996
21
Primary pulmonary sarcoma presenting as an atrial myxoma: intraoperative transesophageal echocardiographic evaluation. ( 7579124 )
1995
22
Establishment of a new lung sarcoma cell line from a human lung carcinosarcoma. ( 8050085 )
1994
23
Simultaneous primary lung sarcoma and carcinoma. ( 1556872 )
1992
24
Blocking of lectin-like adhesion molecules on pulmonary cells inhibits lung sarcoma L-1 colonization in BALB/c-mice. ( 2737266 )
1989
25
Primary pulmonary sarcoma. ( 2838422 )
1988
26
A primary pulmonary sarcoma in a rhesus monkey after inhalation of plutonium dioxide. ( 3685265 )
1987
27
Long-term development of a primary lung sarcoma, probably lymphangiosarcoma--a case report. ( 6206599 )
1984
28
Primary pulmonary sarcoma with left atrial extension via left superior pulmonary vein. En bloc resection and radical pneumonectomy on cardiopulmonary bypass. ( 6748712 )
1984
29
Intravascular and sclerosing bronchioloalveolar tumor. A pulmonary sarcoma of probable vascular origin. ( 7325275 )
1981
30
RESECTION OF PRIMARY PULMONARY SARCOMA. REVIEW OF LITERATURE AND REPORT OF A CASE ASSOCIATED WITH PULMONARY ASBESTOSIS. ( 14159048 )
1964
31
Lung sarcoma. ( 21022634 )
1946

Variations for Lung Sarcoma

Expression for Lung Sarcoma

Search GEO for disease gene expression data for Lung Sarcoma.

Pathways for Lung Sarcoma

Pathways related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 SFTPA1 SFTPA2
2
Show member pathways
11.34 SFTPA1 SFTPA2
3 11.2 SFTPA1 SFTPA2
4 11.06 SFTPA1 SFTPA2
5
Show member pathways
10.82 SFTPA1 SFTPA2
6
Show member pathways
10.59 SFTPA1 SFTPA2
7
Show member pathways
10.02 SFTPA1 SFTPA2

GO Terms for Lung Sarcoma

Cellular components related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 9.32 SFTPA1 SFTPA2
2 rough endoplasmic reticulum GO:0005791 9.26 SFTPA1 SFTPA2
3 multivesicular body GO:0005771 9.16 SFTPA1 SFTPA2
4 clathrin-coated endocytic vesicle GO:0045334 8.96 SFTPA1 SFTPA2
5 lamellar body GO:0042599 8.62 SFTPA1 SFTPA2

Biological processes related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 SFTPA1 SFTPA2
2 somatic stem cell population maintenance GO:0035019 9.4 SALL1 SKI
3 positive regulation of phagocytosis GO:0050766 9.37 SFTPA1 SFTPA2
4 positive regulation of Wnt signaling pathway GO:0030177 9.32 SALL1 SKI
5 toll-like receptor signaling pathway GO:0002224 9.26 SFTPA1 SFTPA2
6 respiratory gaseous exchange GO:0007585 9.16 SFTPA1 SFTPA2
7 positive regulation of DNA binding GO:0043388 8.96 NME1 SKI
8 surfactant homeostasis GO:0043129 8.62 SFTPA1 SFTPA2

Molecular functions related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.16 SFTPA1 SFTPA2
2 lipopolysaccharide binding GO:0001530 8.96 SFTPA1 SFTPA2
3 monosaccharide binding GO:0048029 8.62 SFTPA1 SFTPA2

Sources for Lung Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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