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MCID: LNG037
MIFTS: 32

Lung Sarcoma

Categories: Cancer diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lung Sarcoma

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MalaCards integrated aliases for Lung Sarcoma:

Name: Lung Sarcoma 12 15 71
Pulmonary Sarcoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2784
NCIt 49 C4860
UMLS 71 C0598790
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Summaries for Lung Sarcoma

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Disease Ontology : 12 A lung cancer that is located in the lung and that arises from transformed cells of mesenchymal origin.

MalaCards based summary : Lung Sarcoma, also known as pulmonary sarcoma, is related to spindle cell sarcoma and biphasic synovial sarcoma. An important gene associated with Lung Sarcoma is SSX2 (SSX Family Member 2), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drugs Sorafenib and Panobinostat have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Lung Sarcoma

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Diseases related to Lung Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 30.5 SSX2 SSX1 SERPINA3 CD34
2 biphasic synovial sarcoma 30.0 SSX2 SSX1
3 neurilemmoma 30.0 SERPINA3 CD34 CALB2
4 benign mesothelioma 29.9 CD34 CALB2
5 spindle cell synovial sarcoma 29.8 SSX2 SSX1 CD34
6 hemangiopericytoma, malignant 29.7 SSX2 SSX1 SERPINA3 CD34
7 fibrosarcoma 29.6 SSX2 SSX1 EWSR1
8 monophasic synovial sarcoma 29.5 SSX2 SSX1 CD34 CALB2
9 fibrous histiocytoma 29.5 SERPINA3 EWSR1 CD34
10 sarcoma 29.4 TAF15 SSX2 SSX1 SKI SERPINA3 EWSR1
11 liposarcoma 29.1 TAF15 EWSR1 CD34 CALB2
12 sarcoma, synovial 29.1 SSX2 SSX1 SERPINA3 EWSR1 CD34 CALB2
13 epithelioid cell synovial sarcoma 10.4 SSX2 SSX1
14 synovium neoplasm 10.4 SSX2 SSX1
15 sarcomatoid squamous cell skin carcinoma 10.4 SERPINA3 CD34
16 malignant granular cell myoblastoma 10.4 SERPINA3 CD34
17 liver sarcoma 10.3 SERPINA3 CD34
18 pleomorphic lipoma 10.3 SERPINA3 CD34
19 adult fibrosarcoma 10.3 SSX1 CD34
20 epithelioid malignant peripheral nerve sheath tumor 10.3 SSX2 CD34
21 malignant glandular tumor of peripheral nerve sheath 10.3 SSX2 CALB2
22 breast malignant phyllodes tumor 10.3 SERPINA3 CD34
23 esophagus sarcoma 10.3 SSX2 CD34
24 liver fibroma 10.3 SSX2 CALB2
25 extraosseous osteosarcoma 10.3 SSX1 CD34
26 cellular schwannoma 10.3 SSX1 CD34
27 tenosynovial giant cell tumor 10.3 SERPINA3 CD34
28 malignant spindle cell melanoma 10.3 SERPINA3 CD34
29 myofibroma 10.3 SERPINA3 CD34
30 adult xanthogranuloma 10.3 SERPINA3 CD34
31 skin tag 10.3 SERPINA3 CD34
32 pacinian tumor 10.3 CD34 CALB2
33 benign fibrous mesothelioma 10.3 CD34 CALB2
34 testicular fibroma 10.3 CD34 CALB2
35 liver leiomyosarcoma 10.3 CD34 CALB2
36 pseudosarcomatous fibromatosis 10.3 SERPINA3 CD34
37 cutaneous fibrous histiocytoma 10.2 SERPINA3 CD34
38 extraskeletal chondroma 10.2 SERPINA3 EWSR1
39 mast cell neoplasm 10.2 SERPINA3 CD34
40 kidney sarcoma 10.2 SSX2 EWSR1
41 benign peritoneal mesothelioma 10.2 CD34 CALB2
42 nasal cavity benign neoplasm 10.2 EWSR1 CD34
43 thoracic benign neoplasm 10.2 SERPINA3 CD34
44 malignant mesenchymoma 10.2 SSX2 SERPINA3 CD34
45 breast benign neoplasm 10.2 SERPINA3 CD34
46 spermatic cord cancer 10.2 SSX2 SSX1 CD34
47 heart sarcoma 10.2 SSX2 SSX1 CD34
48 pediatric fibrosarcoma 10.2 SERPINA3 EWSR1
49 conventional central osteosarcoma 10.1 SERPINA3 EWSR1
50 congenital fibrosarcoma 10.1 SERPINA3 EWSR1

Graphical network of the top 20 diseases related to Lung Sarcoma:



Diseases related to Lung Sarcoma
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Symptoms & Phenotypes for Lung Sarcoma

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GenomeRNAi Phenotypes related to Lung Sarcoma according to GeneCards Suite gene sharing:

26 (show all 35)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.98 EWSR1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.98 EWSR1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.98 EWSR1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.98 EWSR1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.98 SKI
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-214 9.98 SKI
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-215 9.98 SKI
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.98 EWSR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.98 SSX1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-45 9.98 NAPSA
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.98 SKI
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.98 EWSR1 SSX1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.98 EWSR1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.98 NAPSA
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.98 SSX2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.98 EWSR1 SKI
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.98 EWSR1 SSX2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.98 EWSR1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.62 EWSR1 NAPSA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.62 CD34
21 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.62 EWSR1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.62 EWSR1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.62 NAPSA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.62 EWSR1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-203 9.62 CD34 EWSR1 NAPSA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.62 NAPSA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.62 CD34
28 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.62 NAPSA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.62 EWSR1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.62 CD34
31 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.62 NAPSA
32 Increased shRNA abundance (Z-score > 2) GR00366-A-55 9.62 NAPSA
33 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.62 NAPSA
34 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.62 EWSR1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.62 EWSR1
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Drugs & Therapeutics for Lung Sarcoma

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Drugs for Lung Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239 406563
2
Panobinostat Approved, Investigational Phase 1 404950-80-7 6918837
3
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
4
Vinorelbine Approved, Investigational Phase 1 71486-22-1 60780 44424639
5
Clotrimazole Approved, Vet_approved Phase 1 23593-75-1 2812
6
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
7
Sirolimus Approved, Investigational Phase 1 53123-88-9 5284616 6436030 46835353
8
Mifepristone Approved, Investigational Phase 1 84371-65-3 55245
9
Sargramostim Approved, Investigational Phase 1 83869-56-1, 123774-72-1
10
Modafinil Approved, Investigational Phase 1 68693-11-8 4236
11 Molgramostim Investigational Phase 1 99283-10-0
12 Protein Kinase Inhibitors Phase 1
13 Histone Deacetylase Inhibitors Phase 1
14 Anti-Infective Agents Phase 1
15 Immunologic Factors Phase 1
16 Immunosuppressive Agents Phase 1
17 Anti-Bacterial Agents Phase 1
18 Antifungal Agents Phase 1
19 Tubulin Modulators Phase 1
20 Antibiotics, Antitubercular Phase 1
21 Antimitotic Agents Phase 1
22 Contraceptive Agents Phase 1
23 Hormone Antagonists Phase 1
24 Hormones Phase 1
25 Contraceptives, Oral Phase 1
26 Contraceptives, Postcoital Phase 1
27 Central Nervous System Stimulants Phase 1
28 Vaccines Phase 1
29 Liver Extracts Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Intravenous REOLYSIN® (Wild-Type Reovirus) in the Treatment of Patients With Bone and Soft Tissue Sarcomas Metastatic to the Lung Completed NCT00503295 Phase 2
2 A Phase I Safety and Tolerability Study of LBH589 in Combination With Sorafenib in Patients With Advanced Renal Cell Carcinoma, Soft Tissue Sarcoma, and Non-small Cell Lung Carcinoma (NSCLC) of Non-squamous Histologies. Completed NCT01005797 Phase 1 Panobinostat (LBH589), Sorafenib
3 Phase I Study of Targeted Lung Chemotherapy in the Treatment of Metastatic Tumors Completed NCT01014598 Phase 1 Cisplatin
4 Phase I Clinical Trial of Temsirolimus and Vinorelbine in Advanced Solid Tumors. Completed NCT01155258 Phase 1 temsirolimus;vinorelbine ditartrate
5 Phase 1 Study of Mifepristone in Combination With Eribulin in Patients With Locally Advanced/Metastatic Breast or Other Specified Solid Tumors, With a Dose Expansion Cohort in Patients With Triple Negative Breast Cancer. Completed NCT02014337 Phase 1 Mifepristone and Eribulin in combination
6 Phase I Trial of Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Vaccine for Advanced Cancer Completed NCT01061840 Phase 1

Search NIH Clinical Center for Lung Sarcoma

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Genetic Tests for Lung Sarcoma

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Anatomical Context for Lung Sarcoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Lung Sarcoma:

19
Lung

MalaCards organs/tissues related to Lung Sarcoma:

40
Lung, Breast, Bone, Liver, Heart, Colon, Skin
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Publications for Lung Sarcoma

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Articles related to Lung Sarcoma:

(show top 50) (show all 169)
# Title Authors PMID Year
1
Multimodality treatment including surgery for primary pulmonary sarcoma: Size does matter. 61
32410271 2020
2
[Surgical Treatment for Primary Pulmonary Artery Sarcoma;Report of a Case]. 61
32393693 2020
3
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a case report and review of the literature. 61
32039736 2020
4
Successful Multidisciplinary Treatment for Aggressive Primary Pulmonary Undifferentiated Pleomorphic Sarcoma. 61
32355494 2020
5
Gross tumor volume segmentation for head and neck cancer radiotherapy using deep dense multi-modality network. 61
31514173 2019
6
Surgical Outcomes and Risk Analysis of Primary Pulmonary Sarcoma. 61
31499540 2019
7
Primary pulmonary sarcoma - treatment outcomes depending on the different types of radical operation. 61
31043968 2019
8
Surgical treatment of primary pulmonary sarcoma disseminated to both pulmonary arteries using composite pulmonary trunk and bifurcation of abdominal aorta allograft. 61
30647750 2018
9
Primary pulmonary sarcoma - long-term treatment outcomes and prognostic factors. 61
30310394 2018
10
TTB2 induces apoptosis in Ewing sarcoma cells. 61
30116354 2018
11
Use of Radiation Therapy Within the Last Year of Life Among Cancer Patients. 61
29487025 2018
12
MicroRNA-associated carcinogenesis in lung carcinoma. 61
29516903 2018
13
An extremely rare lung tumor of a young adult: Primary synovial sarcoma. 61
32082727 2018
14
[Primary pulmonary sarcoma in a patient with pulmonary fibrosis and emphysema]. 61
28571658 2017
15
Pulmonary metastasectomy for sarcoma-Essen experience. 61
29119015 2017
16
Primary Pulmonary Myxoid Sarcoma: A Newly Described Entity-Report of a Case and Review of the Literature. 61
28449608 2017
17
A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors. 61
28881739 2017
18
The Use of Cardiac Resynchronization Therapy in Cancer Patients with Heart Failure. 61
29962508 2017
19
Primary lung sarcoma treated with stereotactic ablative radiotherapy: a case report. 61
28740403 2017
20
Diagnosis of a rare primary pulmonary synovial sarcoma with endobronchial ultrasound-guided transbronchial needle aspiration. 61
27755806 2016
21
[Interventional Bronchoscopy for the Treatment of Pulmonary Sarcoma]. 61
27666549 2016
22
Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy. 61
26831661 2016
23
An example of difficulty in diagnosising and treating lung sarcoma. 61
25900706 2016
24
Hemoptysis in a patient with multifocal primary pulmonary angiosarcoma. 61
27672071 2016
25
Primary pulmonary synovial sarcoma: A case report and review of literature. 61
26958527 2016
26
Single-port video-assisted thoracoscopic pulmonary segmentectomy: a report on 30 cases†. 61
26612717 2016
27
High-grade primary myxoid lung sarcoma presenting as recurrent hemorrhagic pleural effusions in a young woman. 61
27489706 2015
28
Radiation Therapy-Induced Cardiovascular Disease Treated by a Percutaneous Approach. 61
26064696 2015
29
Antitumor and Immunomodulating Activities of Exopolysaccharide Produced by Big Cup Culinary- Medicinal Mushroom Clitocybe maxima (Higher Basidiomycetes) in Liquid Submerged Culture. 61
26756301 2015
30
Bilateral anterior sternothoracotomy (clamshell incision): a suitable alternative for bilateral lung sarcoma metastasis in children. 61
25064077 2014
31
Low-Dose Vascular Photodynamic Therapy Decreases Tumor Interstitial Fluid Pressure, which Promotes Liposomal Doxorubicin Distribution in a Murine Sarcoma Metastasis Model. 61
24836648 2014
32
Incidence of pulmonary non-epithelial tumors: 18 years' experience at a single institute. 61
24405941 2014
33
Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma. 61
24507991 2014
34
Malignant fibrous histiocytoma presenting with complete opacification of the hemithorax: A case report. 61
25437664 2014
35
A case of pulmonary sarcoma with significant extension into the right lung. 61
25477969 2014
36
Therapeutic bronchoscopy followed by lobectomy for pulmonary sarcoma. 61
23857209 2013
37
[Progredient "pulmonary thromboembolism" in spite of sufficient anticoagulant therapy?]. 61
23512363 2013
38
An analysis of patient characteristics and clinical outcomes in primary pulmonary sarcoma. 61
23263688 2013
39
Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. 61
24267748 2013
40
Reliability of oral examinations: Radiation oncology certifying examination. 61
24674266 2013
41
Primary pulmonary sarcoma metastasising to the skin during pregnancy. 61
23866489 2012
42
[Analysis of 19 cases of primary pulmonary sarcoma]. 61
22681925 2012
43
Metastatic atrial sarcoma extending from the lung into the left atrium via a pulmonary vein. 61
22826652 2012
44
Relapsed pulmonary sarcoma presenting as congestive heart failure. 61
21509609 2011
45
Growth patterns of lung metastases from sarcomas. 61
21732122 2011
46
P-glycoprotein modulation by valspodar and cyclosporin does not increase tumor uptake of doxorubicin administered via isolated lung perfusion to rats bearing sarcoma lung metastases. 61
21737631 2011
47
Dedifferentiated chondrosarcoma of the lung: report of a case. 61
21264763 2011
48
Biomonitoring and biomarkers of organophosphate pesticides exposure - state of the art. 61
22216802 2011
49
[Primary pulmonary sarcoma-a study of 8 cases]. 61
20450547 2010
50
A rare reason for pulmonary hypertension: primary sarcoma of the pulmonary artery. 61
20150036 2010
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Variations for Lung Sarcoma

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Expression for Lung Sarcoma

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Search GEO for disease gene expression data for Lung Sarcoma.
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Pathways for Lung Sarcoma

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Pathways related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Transcriptional misregulation in cancer 36
11.21 TAF15 SSX2 SSX1 EWSR1
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GO Terms for Lung Sarcoma

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Biological processes related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell motility GO:0048870 8.62 SKI CD34
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Sources for Lung Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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