MCID: LNG037
MIFTS: 28

Lung Sarcoma

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Lung Sarcoma

MalaCards integrated aliases for Lung Sarcoma:

Name: Lung Sarcoma 11 14 71
Pulmonary Sarcoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:2784
NCIt 49 C4860
UMLS 71 C0598790

Summaries for Lung Sarcoma

Disease Ontology: 11 A lung cancer that is located in the lung and that arises from transformed cells of mesenchymal origin.

MalaCards based summary: Lung Sarcoma, also known as pulmonary sarcoma, is related to fibrosarcoma and cutaneous fibrous histiocytoma. An important gene associated with Lung Sarcoma is SSX2 (SSX Family Member 2), and among its related pathways/superpathways is Chromatin Regulation / Acetylation. Affiliated tissues include lung, heart and breast, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Lung Sarcoma

Diseases related to Lung Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 fibrosarcoma 29.8 EWSR1 BCL2 ALK
2 cutaneous fibrous histiocytoma 29.8 CD34 CALD1
3 lung sarcomatoid carcinoma 29.6 CALB2 ALK
4 lung leiomyosarcoma 29.4 CD34 CALD1 CALB2
5 fibrous histiocytoma 29.3 EWSR1 CD34 CALD1 ALK
6 spindle cell synovial sarcoma 28.9 SSX2 SSX1 SS18 CD34 CALD1
7 sarcoma, synovial 28.8 SSX2 SSX1 SS18 MYOG EWSR1 CD34
8 sarcoma 28.8 TAF15 SSX2 SSX1 SS18 MYOG EWSR1
9 biphasic synovial sarcoma 28.6 SSX2 SSX1 SS18 EWSR1 CD34 CALB2
10 spindle cell sarcoma 28.6 SSX2 SSX1 SS18 MYOG EWSR1 CD34
11 rhabdomyosarcoma 28.5 SSX2 SSX1 MYOG EWSR1 BCL2 ALK
12 monophasic synovial sarcoma 28.2 SSX2 SSX1 SS18 MYOG EWSR1 CD34
13 ovarian angiosarcoma 10.3 SSX2 CD34
14 liver fibroma 10.3 SSX2 CALB2
15 sarcomatoid renal cell carcinoma 10.2 SSX2 CD34
16 pacinian tumor 10.2 CD34 CALB2
17 aorta angiosarcoma 10.2 CD34 BCL2
18 ovarian solid teratoma 10.2 CD34 BCL2
19 pleomorphic lipoma 10.2 EWSR1 CD34
20 pericardium cancer 10.2 SS18 CALB2
21 chordoid meningioma 10.2 EWSR1 CD34
22 meninges hemangiopericytoma 10.2 CD34 BCL2
23 mediastinal cancer 10.2 CD34 CALB2
24 metatypical basal cell carcinoma 10.2 CD34 BCL2
25 sclerosing liposarcoma 10.2 TAF15 CD34
26 cystic teratoma 10.2 CD34 CALB2
27 orbital cancer 10.1 CD34 BCL2
28 invasive malignant thymoma 10.1 EWSR1 CD34
29 liposarcoma of bone 10.1 MYOG CD34
30 parietal lobe neoplasm 10.1 MYOG CD34
31 spermatic cord cancer 10.1 SSX2 SSX1 CD34
32 mesenchymal chondrosarcoma 10.1 MYOG EWSR1
33 cervical carcinosarcoma 10.1 MYOG CALB2
34 prostate sarcoma 10.1 MYOG CD34
35 cystic lymphangioma 10.1 CD34 CALB2
36 granular cell tumor 10.1 CALB2 BCL2
37 hobnail hemangioma 10.1 MYOG CD34
38 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.1 CD34 BCL2
39 prostate stromal sarcoma 10.1 MYOG CD34
40 myoblastoma 10.1 MYOG CALB2
41 breast sarcoma 10.1 MYOG CD34
42 synovium neoplasm 10.1 SSX2 SSX1 SS18
43 myoepithelial carcinoma 10.1 SS18 EWSR1
44 meninges sarcoma 10.1 SSX2 SS18 CD34
45 ossifying fibromyxoid tumor 10.1 SS18 EWSR1
46 parachordoma 10.1 TAF15 EWSR1
47 large cell carcinoma with rhabdoid phenotype 10.1 MYOG CALB2
48 cellular schwannoma 10.1 SSX1 SS18 CD34
49 inflammatory liposarcoma 10.1 CD34 ALK
50 central nervous system mesenchymal non-meningothelial tumor 10.1 MYOG EWSR1

Graphical network of the top 20 diseases related to Lung Sarcoma:



Diseases related to Lung Sarcoma

Symptoms & Phenotypes for Lung Sarcoma

GenomeRNAi Phenotypes related to Lung Sarcoma according to GeneCards Suite gene sharing:

25 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-1 9.84 SSX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.84 SSX2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.84 EWSR1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.84 BCL2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.84 SSX1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.84 BCL2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.84 SSX1 SSX2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.84 EWSR1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.84 BCL2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.84 EWSR1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.84 BCL2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.84 EWSR1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.84 SSX2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.84 BCL2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.84 BCL2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-203 9.84 EWSR1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-206 9.84 SSX1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.84 BCL2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.84 SSX2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.84 BCL2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.84 EWSR1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-59 9.84 BCL2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.84 SSX1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.84 BCL2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.84 BCL2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.84 BCL2 SSX1 SSX2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.84 BCL2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.84 EWSR1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.84 BCL2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.84 EWSR1

Drugs & Therapeutics for Lung Sarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Cancer Research UK Phase I/IIa Clinical Trial of BT1718, (A Bicycle Drug Conjugate) Given Intravenously in Patients With Advanced Solid Tumours. Recruiting NCT03486730 Phase 1, Phase 2 BT1718
2 A Prospective, Phase III Study to Assess the Efficacy and Safety of Microwave Ablation of Metastatic Lung Sarcoma Lesions. Unknown status NCT04510714

Search NIH Clinical Center for Lung Sarcoma

Genetic Tests for Lung Sarcoma

Anatomical Context for Lung Sarcoma

Organs/tissues related to Lung Sarcoma:

FMA: Lung
MalaCards : Lung, Heart, Breast, Skin

Publications for Lung Sarcoma

Articles related to Lung Sarcoma:

(show top 50) (show all 193)
# Title Authors PMID Year
1
Stereotactic Body Radiation Therapy for Lung Metastases From Sarcoma in Oligometastatic Patients: A Phase 2 Study. 62
35987453 2022
2
Complete response to sotorasib as neoadjuvant treatment in patient with locally advanced primary pulmonary sarcoma harboring KRAS mutation: a case report. 62
36388799 2022
3
[Intimal pulmonary sarcoma: A case report of a rare differential diagnosis of chronic thromboembolic pulmonary hypertension]. 62
36104018 2022
4
Impact of Intraoperative Molecular Imaging after Fluorescent-Guided Pulmonary Metastasectomy for Sarcoma. 62
35426386 2022
5
Primary Pulmonary Myxoid Sarcoma with EWSR1::ATF1 Fusion: A Case Report. 62
35466725 2022
6
IGF-2 INDUCED HYPOGLYCEMIA ASSOCIATED WITH LUNG SARCOMA. 62
36212255 2022
7
Editorial Comment: Outcomes of Cryoablation and Microwave Ablation for Pulmonary Sarcoma Metastases Are Comparable. 62
34643110 2022
8
Clinical features and prognostic factors of pulmonary carcinosarcoma: A nomogram development and validation based on surveillance epidemiology and end results database. 62
36330063 2022
9
Adjuvant chemotherapy is not a decisive factor in improving the overall survival of pulmonary sarcoma: A population-based study. 62
36091171 2022
10
Gaining insights into relevance across cancers based on mutation features of TP53 gene. 62
34786492 2021
11
Surgical Management of Primary Pulmonary Artery Sarcoma. 62
34743005 2021
12
Primary lung sarcoma with gastric metastasis and morphological divergence presenting as melena. 62
34385220 2021
13
Primary lung sarcoma mimicking left atrial myxoma. 62
34220032 2021
14
Late presentation of pulmonary artery pseudoaneurysm following bronchovascular sleeve resection of lung. 62
34233867 2021
15
Outcomes of surgically managed primary lung sarcomas: a National Cancer Database analysis. 62
34277037 2021
16
A Paraneoplastic Leukemoid Reaction in Primary Lung Sarcoma. 62
34150398 2021
17
Multimodality imaging of a rare pulmonary artery sessile mass: a case report. 62
33738410 2021
18
[Primary pulmonary myxoid sarcoma associated with translocation EWSR1-CREB1 and locorregional micrometastases]. 62
33455694 2021
19
Surgical Outcomes and Risk Analysis of Primary Pulmonary Sarcoma. 62
31499540 2021
20
Rare Case of Primary Pulmonary Pleomorphic Liposarcoma Treated With Multimodal Therapy. 62
34984062 2021
21
Expecting the unexpected - Primary mediastinal large B cell lymphoma presenting as huge lung parenchymal mass. 62
33717867 2021
22
Primary pulmonary myxoid sarcoma: report of one case and literature review. 62
33564355 2021
23
Primary Pulmonary Synovial Sarcoma in a 49-Year-Old Male. 62
33415051 2020
24
Multimodality treatment including surgery for primary pulmonary sarcoma: Size does matter. 62
32410271 2020
25
[Surgical Treatment for Primary Pulmonary Artery Sarcoma;Report of a Case]. 62
32393693 2020
26
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a case report and review of the literature. 62
32039736 2020
27
Successful Multidisciplinary Treatment for Aggressive Primary Pulmonary Undifferentiated Pleomorphic Sarcoma. 62
32355494 2020
28
Immunomodulatory Effect of Eriocitrin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis. 62
32749123 2020
29
Gross tumor volume segmentation for head and neck cancer radiotherapy using deep dense multi-modality network. 62
31514173 2019
30
Primary pulmonary sarcoma - treatment outcomes depending on the different types of radical operation. 62
31043968 2019
31
Surgical treatment of primary pulmonary sarcoma disseminated to both pulmonary arteries using composite pulmonary trunk and bifurcation of abdominal aorta allograft. 62
30647750 2018
32
Primary pulmonary sarcoma - long-term treatment outcomes and prognostic factors. 62
30310394 2018
33
TTB2 induces apoptosis in Ewing sarcoma cells. 62
30116354 2018
34
Use of Radiation Therapy Within the Last Year of Life Among Cancer Patients. 62
29487025 2018
35
An extremely rare lung tumor of a young adult: Primary synovial sarcoma. 62
32082727 2018
36
MicroRNA-associated carcinogenesis in lung carcinoma. 62
29516903 2018
37
[Primary pulmonary sarcoma in a patient with pulmonary fibrosis and emphysema]. 62
28571658 2017
38
Pulmonary metastasectomy for sarcoma-Essen experience. 62
29119015 2017
39
Primary Pulmonary Myxoid Sarcoma: A Newly Described Entity-Report of a Case and Review of the Literature. 62
28449608 2017
40
A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors. 62
28881739 2017
41
The Use of Cardiac Resynchronization Therapy in Cancer Patients with Heart Failure. 62
29962508 2017
42
Primary lung sarcoma treated with stereotactic ablative radiotherapy: a case report. 62
28740403 2017
43
Diagnosis of a rare primary pulmonary synovial sarcoma with endobronchial ultrasound-guided transbronchial needle aspiration. 62
27755806 2016
44
[Interventional Bronchoscopy for the Treatment of Pulmonary Sarcoma]. 62
27666549 2016
45
Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy. 62
26831661 2016
46
An example of difficulty in diagnosising and treating lung sarcoma. 62
25900706 2016
47
Single-port video-assisted thoracoscopic pulmonary segmentectomy: a report on 30 cases†. 62
26612717 2016
48
Hemoptysis in a patient with multifocal primary pulmonary angiosarcoma. 62
27672071 2016
49
Primary pulmonary synovial sarcoma: A case report and review of literature. 62
26958527 2016
50
Radiation Therapy-Induced Cardiovascular Disease Treated by a Percutaneous Approach. 62
26064696 2015

Variations for Lung Sarcoma

Expression for Lung Sarcoma

Search GEO for disease gene expression data for Lung Sarcoma.

Pathways for Lung Sarcoma

Pathways related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.21 TAF15 SS18 EWSR1

GO Terms for Lung Sarcoma

Biological processes related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of skeletal muscle fiber development GO:0048743 8.92 MYOG BCL2

Sources for Lung Sarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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