MCID: LNG037
MIFTS: 34

Lung Sarcoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Sarcoma

MalaCards integrated aliases for Lung Sarcoma:

Name: Lung Sarcoma 12 15 73
Pulmonary Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2784
NCIt 50 C4860
UMLS 73 C0598790

Summaries for Lung Sarcoma

Disease Ontology : 12 A lung cancer that is located in the lung and that arises from transformed cells of mesenchymal origin.

MalaCards based summary : Lung Sarcoma, also known as pulmonary sarcoma, is related to acute interstitial pneumonia and melanoma of soft tissue. An important gene associated with Lung Sarcoma is SKI (SKI Proto-Oncogene), and among its related pathways/superpathways are Corticotropin-releasing hormone signaling pathway and Glucocorticoid receptor regulatory network. Affiliated tissues include the lung, lung and neutrophil, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Lung Sarcoma

Graphical network of the top 20 diseases related to Lung Sarcoma:



Diseases related to Lung Sarcoma

Symptoms & Phenotypes for Lung Sarcoma

GenomeRNAi Phenotypes related to Lung Sarcoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.47 SSX2B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.47 SKI
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.47 SSX2B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.47 EWSR1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.47 NME1-NME2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.47 EWSR1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.47 NME1-NME2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.47 EWSR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.47 EWSR1 NME1-NME2 SKI SSX2B
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.47 EWSR1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.47 EWSR1

MGI Mouse Phenotypes related to Lung Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 THBD LYZ NF1 CREB1 PLAT IL18
2 growth/size/body region MP:0005378 9.9 KRT5 THBD LYZ NF1 NME1 CREB1
3 digestive/alimentary MP:0005381 9.86 LYZ NF1 PLAT IL18 SALL1 IL2
4 mortality/aging MP:0010768 9.73 THBD LYZ NF1 NME1 CREB1 PLAT
5 respiratory system MP:0005388 9.17 THBD LYZ NF1 CREB1 PLAT SFTPA1

Drugs & Therapeutics for Lung Sarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 BT1718 in Patients With Advanced Solid Tumours. Recruiting NCT03486730 Phase 1 BT1718

Search NIH Clinical Center for Lung Sarcoma

Genetic Tests for Lung Sarcoma

Anatomical Context for Lung Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Sarcoma:

19
The Lung

MalaCards organs/tissues related to Lung Sarcoma:

41
Lung, Neutrophil, Colon

Publications for Lung Sarcoma

Articles related to Lung Sarcoma:

(show all 14)
# Title Authors Year
1
Primary lung sarcoma treated with stereotactic ablative radiotherapy: a case report. ( 28740403 )
2017
2
Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy. ( 26831661 )
2016
3
High-grade primary myxoid lung sarcoma presenting as recurrent hemorrhagic pleural effusions in a young woman. ( 27489706 )
2015
4
An example of difficulty in diagnosising and treating lung sarcoma. ( 25900706 )
2015
5
Bilateral anterior sternothoracotomy (clamshell incision): a suitable alternative for bilateral lung sarcoma metastasis in children. ( 25064077 )
2014
6
Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. ( 24267748 )
2013
7
Primary lung sarcoma. ( 19892455 )
2010
8
Intense paraneoplastic neutrophilic leukemoid reaction related to a G-CSF-secreting lung sarcoma. ( 16247754 )
2005
9
Technique and results of hyperthermic (41 degrees C) isolated lung perfusion with high-doses of cisplatin for the treatment of surgically relapsing or unresectable lung sarcoma metastasis. ( 12103371 )
2002
10
Establishment of a new lung sarcoma cell line from a human lung carcinosarcoma. ( 8050085 )
1994
11
Simultaneous primary lung sarcoma and carcinoma. ( 1556872 )
1992
12
Blocking of lectin-like adhesion molecules on pulmonary cells inhibits lung sarcoma L-1 colonization in BALB/c-mice. ( 2737266 )
1989
13
Long-term development of a primary lung sarcoma, probably lymphangiosarcoma--a case report. ( 6206599 )
1984
14
Lung sarcoma. ( 21022634 )
1946

Variations for Lung Sarcoma

Expression for Lung Sarcoma

Search GEO for disease gene expression data for Lung Sarcoma.

Pathways for Lung Sarcoma

GO Terms for Lung Sarcoma

Cellular components related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 HIST2H2BE IFNA1 IL18 IL2 LYZ PLAT
2 lamellar body GO:0042599 8.96 SFTPA1 SFTPA2

Biological processes related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adrenal gland development GO:0030325 9.48 NF1 SALL1
2 myelination in peripheral nervous system GO:0022011 9.46 NF1 SKI
3 positive regulation of interleukin-17 production GO:0032740 9.43 IL18 IL2
4 nucleoside diphosphate phosphorylation GO:0006165 9.43 NME1 NME1-NME2 NME2
5 regulation of long-term synaptic potentiation GO:1900271 9.4 CALB2 NF1
6 surfactant homeostasis GO:0043129 9.37 SFTPA1 SFTPA2
7 CTP biosynthetic process GO:0006241 9.33 NME1 NME1-NME2 NME2
8 positive regulation of tissue remodeling GO:0034105 9.32 IL18 IL2
9 GTP biosynthetic process GO:0006183 9.13 NME1 NME1-NME2 NME2
10 UTP biosynthetic process GO:0006228 8.8 NME1 NME1-NME2 NME2

Molecular functions related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monosaccharide binding GO:0048029 8.96 SFTPA1 SFTPA2
2 nucleoside diphosphate kinase activity GO:0004550 8.8 NME1 NME1-NME2 NME2

Sources for Lung Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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