MCID: LNG037
MIFTS: 36

Lung Sarcoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Sarcoma

MalaCards integrated aliases for Lung Sarcoma:

Name: Lung Sarcoma 12 15 74
Pulmonary Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2784
NCIt 51 C4860
UMLS 74 C0598790

Summaries for Lung Sarcoma

Disease Ontology : 12 A lung cancer that is located in the lung and that arises from transformed cells of mesenchymal origin.

MalaCards based summary : Lung Sarcoma, also known as pulmonary sarcoma, is related to acute interstitial pneumonia and melanoma of soft tissue. An important gene associated with Lung Sarcoma is SKI (SKI Proto-Oncogene), and among its related pathways/superpathways are Allograft rejection and Tuberculosis. Affiliated tissues include lung, heart and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Lung Sarcoma

Graphical network of the top 20 diseases related to Lung Sarcoma:



Diseases related to Lung Sarcoma

Symptoms & Phenotypes for Lung Sarcoma

GenomeRNAi Phenotypes related to Lung Sarcoma according to GeneCards Suite gene sharing:

27 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 SSX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.78 EWSR1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.78 EWSR1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.78 NME1-NME2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.78 SKI
6 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.78 EWSR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.78 EWSR1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.78 EWSR1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.78 SSX2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.78 EWSR1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.78 EWSR1 SKI
12 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.78 NME1-NME2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.78 NME1-NME2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.78 EWSR1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.78 NME1-NME2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 SKI
17 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.78 SKI
18 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.78 SSX2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.78 EWSR1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.78 SKI
21 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.78 EWSR1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.78 SKI
23 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.78 SSX2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.78 EWSR1 SSX2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 NME1-NME2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.78 SKI
27 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.78 EWSR1

MGI Mouse Phenotypes related to Lung Sarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.73 CASP9 CHEK2 CREB1 IL18 IL2 KRT5
2 respiratory system MP:0005388 9.17 CASP9 CREB1 IL2 NF1 PLAT SFTPA1

Drugs & Therapeutics for Lung Sarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 BT1718 in Patients With Advanced Solid Tumours. Recruiting NCT03486730 Phase 1 BT1718

Search NIH Clinical Center for Lung Sarcoma

Genetic Tests for Lung Sarcoma

Anatomical Context for Lung Sarcoma

MalaCards organs/tissues related to Lung Sarcoma:

42
Lung, Heart, Skin, Colon, Neutrophil, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Sarcoma:

20
The Lung

Publications for Lung Sarcoma

Articles related to Lung Sarcoma:

(show all 36)
# Title Authors Year
1
Primary pulmonary sarcoma - treatment outcomes depending on the different types of radical operation. ( 31043968 )
2019
2
Surgical treatment of primary pulmonary sarcoma disseminated to both pulmonary arteries using composite pulmonary trunk and bifurcation of abdominal aorta allograft. ( 30647750 )
2018
3
Primary pulmonary sarcoma - long-term treatment outcomes and prognostic factors. ( 30310394 )
2018
4
Primary lung sarcoma treated with stereotactic ablative radiotherapy: a case report. ( 28740403 )
2017
5
An example of difficulty in diagnosising and treating lung sarcoma. ( 25900706 )
2016
6
Effect of Shenfu injection on immune function of mice bearing Lewis lung sarcoma with chemotherapy. ( 26831661 )
2016
7
High-grade primary myxoid lung sarcoma presenting as recurrent hemorrhagic pleural effusions in a young woman. ( 27489706 )
2015
8
Bilateral anterior sternothoracotomy (clamshell incision): a suitable alternative for bilateral lung sarcoma metastasis in children. ( 25064077 )
2014
9
A case of pulmonary sarcoma with significant extension into the right lung. ( 25477969 )
2014
10
Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. ( 24267748 )
2013
11
An analysis of patient characteristics and clinical outcomes in primary pulmonary sarcoma. ( 23263688 )
2013
12
Therapeutic bronchoscopy followed by lobectomy for pulmonary sarcoma. ( 23857209 )
2013
13
Primary pulmonary sarcoma metastasising to the skin during pregnancy. ( 23866489 )
2012
14
Relapsed pulmonary sarcoma presenting as congestive heart failure. ( 21509609 )
2011
15
Primary lung sarcoma. ( 19892455 )
2010
16
Intense paraneoplastic neutrophilic leukemoid reaction related to a G-CSF-secreting lung sarcoma. ( 16247754 )
2005
17
Pulmonary sarcoma complicated with neurofibromatosis type 1 (NF1). ( 12680156 )
2003
18
Hypertrophic osteopathy secondary to pulmonary sarcoma in a cat. ( 19379184 )
2003
19
Technique and results of hyperthermic (41 degrees C) isolated lung perfusion with high-doses of cisplatin for the treatment of surgically relapsing or unresectable lung sarcoma metastasis. ( 12103371 )
2002
20
Relationship between the concentration of CDDP in tumor and tumor size after isolated lung perfusion treatment experimental study on a solitary pulmonary sarcoma model in rats. ( 11088051 )
2000
21
Primary pulmonary sarcoma: a clinicopathologic study of 26 cases. ( 10619264 )
1999
22
Primary pulmonary sarcoma with morphologic features of biphasic synovial sarcoma: a case report. ( 9539323 )
1998
23
Experimental pulmonary sarcoma metastases in athymic nude mice. ( 9209524 )
1997
24
Primary pulmonary sarcoma with morphologic features of monophasic synovial sarcoma and chromosome translocation t(X; 18). ( 8607444 )
1996
25
Isolated lung perfusion with melphalan for the treatment of metastatic pulmonary sarcoma. ( 8975846 )
1996
26
Primary pulmonary sarcoma presenting as an atrial myxoma: intraoperative transesophageal echocardiographic evaluation. ( 7579124 )
1995
27
Establishment of a new lung sarcoma cell line from a human lung carcinosarcoma. ( 8050085 )
1994
28
Simultaneous primary lung sarcoma and carcinoma. ( 1556872 )
1992
29
Blocking of lectin-like adhesion molecules on pulmonary cells inhibits lung sarcoma L-1 colonization in BALB/c-mice. ( 2737266 )
1989
30
Primary pulmonary sarcoma. ( 2838422 )
1988
31
A primary pulmonary sarcoma in a rhesus monkey after inhalation of plutonium dioxide. ( 3685265 )
1987
32
Long-term development of a primary lung sarcoma, probably lymphangiosarcoma--a case report. ( 6206599 )
1984
33
Primary pulmonary sarcoma with left atrial extension via left superior pulmonary vein. En bloc resection and radical pneumonectomy on cardiopulmonary bypass. ( 6748712 )
1984
34
Intravascular and sclerosing bronchioloalveolar tumor. A pulmonary sarcoma of probable vascular origin. ( 7325275 )
1981
35
RESECTION OF PRIMARY PULMONARY SARCOMA. REVIEW OF LITERATURE AND REPORT OF A CASE ASSOCIATED WITH PULMONARY ASBESTOSIS. ( 14159048 )
1964
36
Lung sarcoma. ( 21022634 )
1946

Variations for Lung Sarcoma

Expression for Lung Sarcoma

Search GEO for disease gene expression data for Lung Sarcoma.

Pathways for Lung Sarcoma

GO Terms for Lung Sarcoma

Cellular components related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 HIST2H2BE IFNA1 IL18 IL2 PLAT SFTPA1
2 lamellar body GO:0042599 8.62 SFTPA1 SFTPA2

Biological processes related to Lung Sarcoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 myelination in peripheral nervous system GO:0022011 9.51 NF1 SKI
2 cellular response to fatty acid GO:0071398 9.5 CREB1 NME1 NME2
3 positive regulation of interleukin-17 production GO:0032740 9.49 IL18 IL2
4 signal transduction in response to DNA damage GO:0042770 9.48 CASP9 CHEK2
5 regulation of long-term synaptic potentiation GO:1900271 9.46 CALB2 NF1
6 surfactant homeostasis GO:0043129 9.43 SFTPA1 SFTPA2
7 nucleoside diphosphate phosphorylation GO:0006165 9.43 NME1 NME1-NME2 NME2
8 positive regulation of tissue remodeling GO:0034105 9.4 IL18 IL2
9 negative regulation of myeloid leukocyte differentiation GO:0002762 9.37 NME1 NME2
10 CTP biosynthetic process GO:0006241 9.33 NME1 NME1-NME2 NME2
11 GTP biosynthetic process GO:0006183 9.13 NME1 NME1-NME2 NME2
12 UTP biosynthetic process GO:0006228 8.8 NME1 NME1-NME2 NME2

Molecular functions related to Lung Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monosaccharide binding GO:0048029 9.16 SFTPA1 SFTPA2
2 intermediate filament binding GO:0019215 8.96 NME1 NME2
3 nucleoside diphosphate kinase activity GO:0004550 8.8 NME1 NME1-NME2 NME2

Sources for Lung Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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