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MCID: LTM001
MIFTS: 23

Lutembacher's Syndrome

Categories: Cardiovascular diseases
Genes Related diseases Publications
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Aliases & Classifications for Lutembacher's Syndrome

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MalaCards integrated aliases for Lutembacher's Syndrome:

Name: Lutembacher's Syndrome 12 15 17
Lutembacher Syndrome 12 44 71
Lutembacher's Anomaly 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1998
MeSH 44 D008185
SNOMED-CT 67 204319006
UMLS 71 C0024164
Sources

Summaries for Lutembacher's Syndrome

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MalaCards based summary : Lutembacher's Syndrome, also known as lutembacher syndrome, is related to mitral valve stenosis and heart septal defect. An important gene associated with Lutembacher's Syndrome is MFAP3 (Microfibril Associated Protein 3). Related phenotype is cardiovascular system.

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Related Diseases for Lutembacher's Syndrome

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Diseases related to Lutembacher's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 mitral valve stenosis 10.6
2 heart septal defect 10.6
3 atrial heart septal defect 10.6
4 pulmonary hypertension 10.3
5 cyanosis, transient neonatal 10.1
6 situs inversus 10.1
7 rheumatic heart disease 10.1
8 infective endocarditis 10.1
9 endocarditis 10.1
10 tricuspid valve insufficiency 10.1
11 mitral valve disease 10.1
12 interatrial communication 10.1
13 tricuspid valve stenosis 10.1
14 congestive heart failure 10.1
15 wolff-parkinson-white syndrome 9.9
16 rheumatic fever-related antigen 9.9
17 pallister w syndrome 9.9
18 meningioma, familial 9.9
19 aortic valve disease 2 9.9
20 cryptogenic organizing pneumonia 9.9
21 spinal meningioma 9.9
22 mitral valve insufficiency 9.9
23 rheumatic fever 9.9
24 bronchiolitis obliterans 9.9
25 bronchiolitis 9.9
26 subacute bacterial endocarditis 9.9
27 secretory meningioma 9.9
28 lymphoplasmacyte-rich meningioma 9.9
29 dextrocardia 9.9
30 lymphangiectasis 9.9
31 atrial septal aneurysm 9.9
32 progressive familial heart block, type ia 9.9
33 pulmonary hypertension, primary, 1 9.9
34 progressive familial heart block, type ib 9.9
35 hydrocephalus 9.9
36 heart disease 9.9
37 hemopericardium 9.9
38 pericardial effusion 9.9
39 right bundle branch block 9.9
40 glycogen storage disease 9.9
41 pulmonary tuberculosis 9.9
42 heart valve disease 9.9
43 meningitis 9.9
44 dextrocardia with situs inversus 9.9
45 tuberculous meningitis 9.9
46 seizure disorder 9.9
47 cardiogenic shock 9.9
48 cleft mitral valve 9.9
49 cartilage cancer 9.8 RAMP2 CALCRL
50 acute closed-angle glaucoma 9.7 RAMP2 CALCRL

Graphical network of the top 20 diseases related to Lutembacher's Syndrome:



Diseases related to Lutembacher's Syndrome
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Symptoms & Phenotypes for Lutembacher's Syndrome

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MGI Mouse Phenotypes related to Lutembacher's Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 AOC1 C1GALT1 CALCRL RAMP2 SOX18 TBX20
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Drugs & Therapeutics for Lutembacher's Syndrome

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Search Clinical Trials , NIH Clinical Center for Lutembacher's Syndrome

Cochrane evidence based reviews: lutembacher syndrome

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Genetic Tests for Lutembacher's Syndrome

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Anatomical Context for Lutembacher's Syndrome

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Publications for Lutembacher's Syndrome

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Articles related to Lutembacher's Syndrome:

(show top 50) (show all 183)
# Title Authors PMID Year
1
An Incidental Diagnosis of Rheumatic Mitral Stenosis and Secundum Atrial Septal Defect (Lutembacher's Syndrome) in a Young Woman. 61
31781405 2019
2
Combined Percutaneous Procedure in Patient with Lutembacher Syndrome: A Case Report and Real-World Experience Review. 61
30627291 2018
3
Surgical challenge in situs inversus with dextrocardia and Lutembacher syndrome. 61
29214824 2018
4
Sinus venosus atrial septal defect with severe mitral stenosis: a rare variant of Lutembacher's syndrome. 61
33060929 2018
5
Lutembacher syndrome with mitral valve calcification in a 31-year old male. 61
29786701 2018
6
Percutaneous Transcatheter Treatment of Lutembacher Syndrome. 61
30341855 2018
7
Lutembacher syndrome: Dilemma of doing a tricuspid annuloplasty. 61
28994686 2017
8
Iatrogenic Lutembacher Syndrome after Percutaneous Mitral Commissurotomy. 61
29092127 2017
9
Lutembacher's syndrome: Is the mitral pathology always rheumatic? 61
28228300 2017
10
Lutembacher syndrome variant: Rheumatic heart disease involving all four valves and associated with an atrial septal defect in a child. 61
29545668 2017
11
Is Transoesophageal Echocardiography Necessary for the Percutaneous Management of Lutembacher Syndrome: A Case Report. 61
27891380 2016
12
Current diagnostic and treatment strategies for Lutembacher syndrome: the pivotal role of echocardiography. 61
25984452 2015
13
Successful ablation of a concealed accessory pathway mediated tachycardia in a patient with Lutembacher syndrome. 61
25295495 2014
14
Surgical correction of Lutembacher's syndrome in a patient with severe pulmonary artery hypertension. 61
24827112 2014
15
Occurrence of Lutembacher syndrome in a rural regional hospital: case report from Buea, Cameroon. 61
25009795 2014
16
Successful percutaneous management of Lutembacher syndrome. 61
24973844 2014
17
[Percutaneous mitral commissurotomy associated to sinus venosus atrial septal defect and partially anomalous pulmonary venous connection: a case report]. 61
22436630 2014
18
Transcatheter therapy for Lutembacher's syndrome: The road less travelled. 61
24701084 2014
19
Echocardiographic assessment of Lutembacher syndrome. 61
25081115 2014
20
Lutembacher's Syndrome Associated with Meningioma. 61
25478492 2013
21
Lutembacher syndrome with unroofed left superior vena cava: a diagnostic dilemma. 61
23064838 2013
22
Substantive treatment of Lutembacher's syndrome by the trans-septal puncture technique: a case report and review. 61
27326136 2013
23
Concomitant tuberculous meningitis and Lutembacher syndrome with multiple atrial septal defects and infective endocarditis. 61
23058155 2012
24
Lutembacher's syndrome. 61
22629045 2012
25
Percutaneous treatment of Lutembacher syndrome in a case with difficult mitral valve crossing. 61
22388316 2012
26
Turbulent left-to-right shunt flow through the interatrial septum suggesting high left atrial pressure in patients with heart failure with preserved ejection fraction. 61
27277178 2011
27
A rare case of situs inversus with dextrocardia, lutembacher syndrome, and pericardial effusion. 61
22567197 2011
28
Platypnea-orthodeoxia syndrome associated with bioprosthetic tricuspid valve stenosis and reverse Lutembacher syndrome. 61
21300958 2011
29
[Temporary occlusion of atrial septal defect in the Lutembacher syndrome]. 61
21893451 2011
30
Trans-catheter therapy of Lutembacher syndrome: a case report. 61
21713755 2011
31
[Percutaneous treatment of Lutembacher syndrome: a case report]. 61
20215845 2010
32
Use of the Amplatzer ASD Occluder for closing a persistent left vertical vein. 61
18791763 2009
33
Partial anomalous pulmonary venous connection associated with Lutembacher's syndrome. 61
18177387 2008
34
Transcatheter treatment of Lutembacher's syndrome. 61
18454897 2008
35
Transcatheter therapy of Lutembacher syndrome. 61
17591586 2007
36
[Percutaneous mitral commissurotomy and Lutembacher syndrome]. 61
16792032 2006
37
A successfully operated case of prosthetic valve thrombosis during planned pregnancy. 61
16572080 2006
38
Lutembacher syndrome: an ideal combination for percutaneous treatment. 61
16537037 2006
39
Transcatheter treatment of Lutembacher syndrome. 61
16336826 2005
40
Lutembacher's syndrome with small atrial septal defect diagnosed by transthoracic and transesophageal echocardiography that underwent mitral valve replacement. 61
16198889 2005
41
Lutembacher's Syndrome. 61
16056214 2005
42
Transcatheter treatment of Lutembacher syndrome: combined balloon mitral valvuloplasty and percutaneous atrial septal defect closure. 61
15550747 2004
43
Echocardiographic assessment of left and right heart hemodynamics in a patient with Lutembacher's syndrome. 61
14983140 2004
44
Transcatheter treatment of Lutembacher syndrome. 61
12752898 2003
45
Non-surgical correction of Lutembacher syndrome. 61
12704512 2003
46
Giant left atrium secondary to tight mitral stenosis leading to acquired Lutembacher syndrome: a case report with emphasis on role of echocardiography in assessment of Lutembacher syndrome. 61
11593210 2001
47
Use of Amplatzer septal occluder in a case of residual atrial septal defect causing bidirectional shunting after percutaneous Inoue mitral balloon valvuloplasty. 61
11231648 2001
48
Transcatheter treatment of a case of Lutembacher syndrome. 61
10816284 2000
49
[Lutembacher's syndrome]. 61
11829943 1999
50
Coexistent atrial septal defect and mitral stenosis (Lutembacher syndrome): An ideal combination for percutaneous treatment. 61
10506781 1999
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Variations for Lutembacher's Syndrome

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Expression for Lutembacher's Syndrome

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Search GEO for disease gene expression data for Lutembacher's Syndrome.
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Pathways for Lutembacher's Syndrome

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GO Terms for Lutembacher's Syndrome

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Cellular components related to Lutembacher's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adrenomedullin receptor complex GO:1903143 8.62 RAMP2 CALCRL

Biological processes related to Lutembacher's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.5 SOX18 RAMP2 CALCRL
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.48 RAMP2 CALCRL
3 muscle contraction GO:0006936 9.46 TBX20 ACTN2
4 heart looping GO:0001947 9.43 TBX20 SOX18
5 outflow tract morphogenesis GO:0003151 9.4 TBX20 SOX18
6 receptor internalization GO:0031623 9.37 RAMP2 CALCRL
7 vasculogenesis GO:0001570 9.33 TBX20 SOX18 RAMP2
8 embryonic heart tube development GO:0035050 9.26 TBX20 SOX18
9 adrenomedullin receptor signaling pathway GO:1990410 8.96 RAMP2 CALCRL
10 angiogenesis GO:0001525 8.92 SOX18 RAMP2 CALCRL C1GALT1

Molecular functions related to Lutembacher's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adrenomedullin receptor activity GO:0001605 8.96 RAMP2 CALCRL
2 adrenomedullin binding GO:1990409 8.62 RAMP2 CALCRL
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Sources for Lutembacher's Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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