MCID: LTM002
MIFTS: 34

Luteoma

Categories: Cancer diseases, Reproductive diseases, Endocrine diseases

Aliases & Classifications for Luteoma

MalaCards integrated aliases for Luteoma:

Name: Luteoma 12 55 44 15 73
Leuteoma of Pregnancy 12
Luteoma of Pregnancy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7880
MeSH 44 D018311
NCIt 50 C40445

Summaries for Luteoma

Disease Ontology : 12 An ovarian benign neoplasm characterized by solid proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium.

MalaCards based summary : Luteoma, also known as leuteoma of pregnancy, is related to acanthosis nigricans and antley-bixler syndrome. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are MAPK Signaling: Mitogen Stimulation Pathway and Corticotropin-releasing hormone signaling pathway. Affiliated tissues include ovary and uterus, and related phenotype is reproductive system.

Wikipedia : 76 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

Related Diseases for Luteoma

Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 acanthosis nigricans 29.9 FGFR2 FGFR3
2 antley-bixler syndrome 29.2 CYP19A1 CYP21A2 FGFR2
3 lipoid congenital adrenal hyperplasia 28.8 CYP19A1 CYP21A2 STAR
4 ovarian disease 28.0 CGA CYP19A1
5 testicular leydig cell tumor 10.3 CYP21A2 STAR
6 steroid inherited metabolic disorder 10.3 CYP21A2 STAR
7 hemifacial hyperplasia 10.3 FGFR2 FGFR3
8 plagiocephaly 10.3 FGFR2 FGFR3
9 osteoglophonic dysplasia 10.3 FGFR2 FGFR3
10 beare-stevenson cutis gyrata syndrome 10.3 FGFR2 FGFR3
11 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.3 CYP21A2 STAR
12 jackson-weiss syndrome 10.3 FGFR2 FGFR3
13 hypoadrenocorticism, familial 10.3 CYP21A2 STAR
14 thanatophoric dysplasia, type i 10.3 FGFR2 FGFR3
15 hypertropia 10.2 FGFR2 FGFR3
16 hypochondroplasia 10.2 FGFR2 FGFR3
17 osteogenesis imperfecta, type ii 10.2 CYP21A2 FGFR3
18 exophthalmos 10.2 FGFR2 FGFR3
19 apert syndrome 10.2 FGFR2 FGFR3
20 lacrimoauriculodentodigital syndrome 10.2 FGFR2 FGFR3
21 achondroplasia 10.2 FGFR2 FGFR3
22 crouzon syndrome 10.2 FGFR2 FGFR3
23 muenke syndrome 10.2 FGFR2 FGFR3
24 bone development disease 10.1 FGFR2 FGFR3
25 adrenal carcinoma 10.1 CYP21A2 STAR
26 chromosome 2q35 duplication syndrome 10.1 FGFR2 FGFR3
27 saethre-chotzen syndrome 10.0 FGFR2 FGFR3
28 pfeiffer syndrome 10.0 FGFR2 FGFR3
29 transsexualism 10.0 CYP19A1 CYP21A2
30 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 10.0
31 alopecia, androgenetic, 1 10.0 CYP19A1 CYP21A2
32 synostosis 10.0 FGFR2 FGFR3
33 sex differentiation disease 10.0 CYP19A1 CYP21A2
34 precocious puberty 9.9 CYP19A1 CYP21A2
35 autosomal dominant disease 9.9 FGFR2 FGFR3
36 ectopic pregnancy 9.8
37 endometriosis 9.8
38 pseudohermaphroditism 9.8
39 krukenberg carcinoma 9.8
40 seminoma 9.8 CGA FGFR3
41 hyperandrogenism 9.8 CYP19A1 CYP21A2
42 oocyte maturation defect 1 9.7 CGA CYP19A1
43 estrogen-receptor positive breast cancer 9.7 CYP19A1 FGFR2
44 complete androgen insensitivity syndrome 9.7 CGA CYP19A1
45 gynecomastia 9.7 CGA CYP19A1
46 anovulation 9.6 CGA CYP19A1
47 ovarian hyperstimulation syndrome 9.6 CGA CYP19A1
48 leydig cell tumor 9.4 CYP19A1 CYP21A2 STAR
49 adrenocortical carcinoma, hereditary 9.4 CYP19A1 CYP21A2 STAR
50 cryptorchidism, unilateral or bilateral 9.4 CGA CYP19A1

Graphical network of the top 20 diseases related to Luteoma:



Diseases related to Luteoma

Symptoms & Phenotypes for Luteoma

MGI Mouse Phenotypes related to Luteoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.02 CGA CYP19A1 FGFR2 FGFR3 STAR

Drugs & Therapeutics for Luteoma

Search Clinical Trials , NIH Clinical Center for Luteoma

Cochrane evidence based reviews: luteoma

Genetic Tests for Luteoma

Anatomical Context for Luteoma

MalaCards organs/tissues related to Luteoma:

41
Ovary, Uterus

Publications for Luteoma

Articles related to Luteoma:

(show top 50) (show all 81)
# Title Authors Year
1
Unilateral luteoma of the ovary in a pregnant Risso's dolphin (Grampus griseus). ( 28845023 )
2017
2
Sclerosing Stromal Tumor Mimicking a Pregnancy Luteoma: Case Report of a Diagnostically Challenging Entity Further Complicated by the Presence of Metastatic Signet Ring Cell Carcinoma From the Stomach. ( 28633616 )
2017
3
Pregnancy Luteoma in Ectopic Pregnancy: A Case Report. ( 29062798 )
2017
4
Luteoma of Pregnancy. ( 28081022 )
2017
5
Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report. ( 27660728 )
2016
6
A puzzling ovarian tumour: pregnancy luteoma with diffuse endometriosis. ( 28195267 )
2016
7
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. ( 27355981 )
2016
8
Pregnancy luteoma: A rare case report. ( 27857898 )
2016
9
A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. ( 26726013 )
2016
10
Pregnancy luteoma followed with massive ascites and elevated CA125 after ovulation induction therapy: a case report and review of literatures. ( 25785161 )
2015
11
Stromal luteoma of the ovary: A rare ovarian pathology. ( 25140903 )
2014
12
Bilateral pregnancy luteoma: a case report. ( 25337317 )
2014
13
Pregnancy Luteoma: A Study of 20 Cases on the Occasion of the 50th Anniversary of its Description by Dr William H. Sternberg, With an Emphasis on the Common Presence of Follicle-like Spaces and Their Diagnostic Implications. ( 24335664 )
2014
14
Luteoma of Pregnancy Associated with Near Complete Virilization of Genetically Female Twins. ( 24126228 )
2013
15
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. ( 19110243 )
2009
16
Luteoma-induced fetal virilization. ( 20149054 )
2009
17
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. ( 19883437 )
2009
18
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. ( 19243065 )
2009
19
Maternal virilization due to luteoma associated with delayed lactation. ( 18635167 )
2008
20
Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. ( 18362993 )
2008
21
Ovarian stromal luteoma in a patient with endometrial carcinoma. ( 18412799 )
2008
22
Maternal luteoma of pregnancy presenting with virilization of the female infant. ( 17915067 )
2007
23
Krukenberg tumor mimicking pregnancy luteoma. ( 17852427 )
2007
24
Stromal luteoma: report of a rare case. ( 17883070 )
2007
25
Luteoma of pregnancy. ( 17000514 )
2006
26
Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata). ( 16053501 )
2005
27
MR imaging of pregnancy luteoma: a case report and correlation with the clinical features. ( 15782020 )
2005
28
Magnetic resonance imaging of pregnancy luteoma. ( 12703004 )
2003
29
Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: case report. ( 11870143 )
2002
30
Luteoma of pregnancy: sonographic findings in two cases. ( 11127014 )
2000
31
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. ( 10664233 )
2000
32
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. ( 10726707 )
2000
33
Pregnancy luteoma with granulosa cell proliferation: an unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia. ( 10631723 )
1999
34
Luteoma of pregnancy presenting with massive ascites and markedly elevated CA 125. ( 10546765 )
1999
35
GnRH receptors and GnRH endocrine effects on luteoma cells. ( 9225131 )
1997
36
Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (Cushing's disease) in a dog. ( 9150550 )
1997
37
A gonadotrophin dependent stromal luteoma: a rare cause of post-menopausal virilization. ( 8548951 )
1995
38
Luteoma of pregnancy: masculinisation of a female fetus prevented by placental aromatisation. ( 1335753 )
1992
39
Luteoma of pregnancy. ( 2157147 )
1990
40
Malignant luteoma in a sow. ( 2551110 )
1989
41
Stromal luteoma of the ovary: a clinicopathological analysis of 25 cases. ( 2826353 )
1987
42
High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma. ( 6094939 )
1984
43
Luteoma of pregnancy. ( 6330914 )
1984
44
[Virilizing luteoma of pregnancy. Relation to polycystic ovaries]. ( 6320393 )
1983
45
In vivo steroid studies in luteoma of pregnancy. ( 6283444 )
1982
46
A case of virilizing luteoma. ( 6244616 )
1980
47
Differential maternal-fetal response to androgenizing luteoma or hyperreactio luteinalis. ( 205819 )
1978
48
Incidental pregnancy luteoma associated with ectopic tubo-ovarian pregnancy: evidence in favor of origin from theca interna of an atretic follicle. ( 233743 )
1978
49
Virilization of mother and fetus associated with luteoma of pregnancy: a case report with endocrinologic studies. ( 197851 )
1977
50
Properties of human gonadotrophins eluted from human corpus luteum and mouse luteoma LH-HCG receptors. ( 188284 )
1977

Variations for Luteoma

Expression for Luteoma

Search GEO for disease gene expression data for Luteoma.

Pathways for Luteoma

GO Terms for Luteoma

Biological processes related to Luteoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.72 CGA FGFR2 FGFR3
2 cell-cell signaling GO:0007267 9.65 CGA FGFR2 FGFR3
3 fibroblast growth factor receptor signaling pathway GO:0008543 9.54 FGFR2 FGFR3
4 positive regulation of kinase activity GO:0033674 9.52 FGFR2 FGFR3
5 cellular response to transforming growth factor beta stimulus GO:0071560 9.51 FGFR2 STAR
6 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.49 FGFR2 FGFR3
7 bone mineralization GO:0030282 9.46 FGFR2 FGFR3
8 cellular response to fibroblast growth factor stimulus GO:0044344 9.43 FGFR2 STAR
9 bone morphogenesis GO:0060349 9.4 FGFR2 FGFR3
10 sterol metabolic process GO:0016125 9.37 CYP19A1 CYP21A2
11 estrogen biosynthetic process GO:0006703 9.32 CYP19A1 STAR
12 positive regulation of phospholipase activity GO:0010518 9.26 FGFR2 FGFR3
13 endochondral bone growth GO:0003416 9.16 FGFR2 FGFR3
14 testosterone biosynthetic process GO:0061370 8.96 CYP19A1 STAR
15 steroid biosynthetic process GO:0006694 8.8 CYP19A1 CYP21A2 STAR

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 9.46 FGFR2 FGFR3
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP19A1 CYP21A2
3 mitogen-activated protein kinase kinase binding GO:0031434 9.4 FGFR2 FGFR3
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.37 FGFR2 FGFR3
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.32 FGFR2 FGFR3
6 1-phosphatidylinositol-3-kinase activity GO:0016303 9.26 FGFR2 FGFR3
7 steroid hydroxylase activity GO:0008395 9.16 CYP19A1 CYP21A2
8 fibroblast growth factor binding GO:0017134 8.96 FGFR2 FGFR3
9 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR2 FGFR3

Sources for Luteoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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