Luteoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Luteoma

MalaCards integrated aliases for Luteoma:

Name: Luteoma ¹¹ ⁵³ ⁴³ ¹⁴ ⁷¹ ⁷⁵

Leuteoma of Pregnancy ¹¹

Luteoma of Pregnancy ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:7880

MeSH ⁴³ D018311

NCIt ⁴⁹ C40445

UMLS ⁷¹ C0024167 C1517842

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Summaries for Luteoma

Disease Ontology: ¹¹ An ovarian benign neoplasm characterized by solid proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium.

MalaCards based summary: Luteoma, also known as leuteoma of pregnancy, is related to hypertelorism, microtia, facial clefting syndrome and cytochrome p450 oxidoreductase deficiency. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metabolism of steroids and Metabolism of steroid hormones. Affiliated tissues include ovary, uterus and spleen, and related phenotypes are growth/size/body region and no phenotypic analysis

Wikipedia: ⁷⁵ A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

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Related Diseases for Luteoma

Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)

#	Related Disease	Score	Top Affiliating Genes
1	hypertelorism, microtia, facial clefting syndrome	30.3	FGFR3 FGFR2
2	cytochrome p450 oxidoreductase deficiency	30.3	CYP21A2 CYP19A1
3	acne	30.2	SHBG CYP21A2 CYP19A1
4	antley-bixler syndrome	29.9	FGFR3 FGFR2 CYP21A2 CYP19A1
5	acanthosis nigricans	29.8	SHBG FGFR3 FGFR2
6	hyperandrogenism	29.7	SHBG CYP21A2 CYP19A1 AMH
7	amenorrhea	29.6	SHBG FOXL2 CYP19A1
8	endometriosis	29.4	STAR CYP19A1 CGA CALB2
9	lipoid congenital adrenal hyperplasia	29.0	STAR SHBG CYP21A2 CYP19A1 AMHR2 AMH
10	polycystic ovary syndrome	28.9	STAR SHBG CYP21A2 CYP19A1 CGA AMH
11	pseudohermaphroditism	28.7	STAR FOXL2 EPPIN CYP21A2 CYP19A1 AMHR2
12	adrenal cortical carcinoma	28.7	STAR MLANA EPPIN CYP21A2 CYP19A1 CALB2
13	ovarian disease	28.5	SHBG FOXL2 EPPIN CYP19A1 CGA AMHR2
14	disorder of sexual development	27.8	STAR SHBG FOXL2 FGFR2 EPPIN CYP21A2
15	cryptorchidism, unilateral or bilateral	27.7	STAR SHBG FOXL2 EPPIN CYP21A2 CYP19A1
16	hemifacial hyperplasia	10.3	FGFR3 FGFR2
17	plagiocephaly	10.3	FGFR3 FGFR2
18	testicular spermatocytic seminoma	10.2	FGFR3 FGFR2
19	adrenal rest tumor	10.2	EPPIN CYP21A2
20	achondroplasia, severe, with developmental delay and acanthosis nigricans	10.2	FGFR3 FGFR2
21	crouzon syndrome with acanthosis nigricans	10.2	FGFR3 FGFR2
22	congenital disorder of glycosylation, type iim	10.2	FGFR3 FGFR2
23	beare-stevenson cutis gyrata syndrome	10.2	FGFR3 FGFR2
24	peritoneal benign neoplasm	10.2	CYP19A1 CALB2
25	cervical keratinizing squamous cell carcinoma	10.2	SHBG FGFR2
26	osteoglophonic dysplasia	10.2	FGFR3 FGFR2
27	mixed germ cell-sex cord neoplasm	10.2	FOXL2 CALB2
28	muenke syndrome	10.2	FGFR3 FGFR2
29	spermatocele	10.1	CALB2 AMHR2
30	thanatophoric dysplasia, type i	10.1	FGFR3 FGFR2
31	adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	10.1	STAR CYP21A2
32	prostatic hypertrophy	10.1	SHBG EPPIN
33	corticosterone methyloxidase type i deficiency	10.1	STAR CYP21A2
34	ectopic pregnancy	10.1
35	hydrocele	10.1	EPPIN CGA CALB2
36	pigmentation disease	10.0	SHBG FGFR3 FGFR2
37	tuberculous epididymitis	10.0	CALB2 AMH
38	androgenic alopecia	10.0	SHBG CYP19A1
39	subserous uterine fibroid	10.0	CYP19A1 AMH
40	ovarian serous cystadenofibroma	10.0	CALB2 AMH
41	ovarian serous adenofibroma	10.0	CALB2 AMH
42	cystic teratoma	10.0	CALB2 AMH
43	alopecia, androgenetic, 1	10.0	SHBG CYP21A2 CYP19A1
44	adrenal cortical hypofunction	10.0	STAR CYP21A2
45	ovarian germ cell cancer	10.0	CALB2 AMH
46	adrenal hypoplasia, congenital	10.0	STAR EPPIN CYP21A2
47	renal cell carcinoma, nonpapillary	10.0
48	adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	10.0
49	endometrial hyperplasia	10.0
50	pre-eclampsia	10.0

Graphical network of the top 20 diseases related to Luteoma:

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Symptoms & Phenotypes for Luteoma

MGI Mouse Phenotypes related to Luteoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.96	AMH AMHR2 CGA CYP19A1 CYP21A2 EPPIN
2	no phenotypic analysis	MP:0003012	9.8	AMH AMHR2 FGFR2 FGFR3 FOXL2 MLANA
3	endocrine/exocrine gland	MP:0005379	9.76	AMH AMHR2 CGA CYP19A1 EPPIN FGFR2
4	reproductive system	MP:0005389	9.61	AMH AMHR2 CGA CYP19A1 EPPIN FGFR2
5	integument	MP:0010771	9.17	AMHR2 CYP19A1 CYP21A2 EPPIN FGFR2 FGFR3

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Drugs & Therapeutics for Luteoma

Search Clinical Trials, NIH Clinical Center for Luteoma

Cochrane evidence based reviews: luteoma

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Genetic Tests for Luteoma

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Anatomical Context for Luteoma

Organs/tissues related to Luteoma:

MalaCards : Ovary, Uterus, Spleen, Pituitary, Breast, Skin

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Publications for Luteoma

Articles related to Luteoma:

(show top 50) (show all 187)

#	Title	Authors	PMID	Year
1	Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. ⁵³ ⁶²	Warmann S...Fuchs J	10726707	2000
2	Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. ⁵³ ⁶²	Roth C...Lakomek M	10664233	2000
3	[Luteinized cystic hyperplasia of the ovaries during pregnancy. A case report]. ⁵³ ⁶²	Degrolard M...Mavel A	1328353	1992
4	Clinicopathologic features of pregnancy luteoma. ⁶²	Wang L...Zhang W	35212399	2022
5	A case of excision of ovarian torsion necrosis due to luteoma in a female who conceived a twin pregnancy through in vitro fertilization misdiagnosed with acute appendicitis. ⁶²	Zhu L...Yang Y	36002954	2022
6	Luteoma of Pregnancy Presenting as Ruptured Ectopic Pregnancy: A Case Report. ⁶²	Agarwal I...Singupuram NP	36465744	2022
7	Luteoma of Pregnancy with Uterine Leiomyoma as a Diagnostic Challenge and Mimicker of Ovarian Malignancy: A Rare Case From Rural India. ⁶²	Dayal S	36045881	2022
8	A RETROSPECTIVE SURVEY OF NEOPLASIA IN MANAGED GIRAFFES (GIRAFFA CAMELOPARDALIS). ⁶²	Doden G...Sander S	33827195	2021
9	Incidental Finding of Bilateral Ovarian Adrenal Rest Tumor in a Patient With Congenital Adrenal Hyperplasia: A Case Report and Brief Review. ⁶²	Bouzidi L...Boudawara T	33433255	2021
10	Hirsutism Caused by Pregnancy Luteoma in a Low-Resource Setting: A Case Report and Literature Review. ⁶²	Mvunta DH...August F	33833884	2021
11	Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch. ⁶²	Ferre-Dolcet L...Mollo A	32778114	2020
12	Unusual Course of Acne Conglobata as a Skin Manifestation due to Bilateral Luteoma of Pregnancy. ⁶²	Smolarczyk K...Majewski S	33911699	2019
13	An Access to Androgen Excess: The Ovary Unregulated. ⁶²	Agrawal N...Pal SK	31562730	2019
14	Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma. ⁶²	Tran L...Lastra RR	29257039	2019
15	Recurrent maternal virilization during pregnancy in patients with PCOS: two clinical cases. ⁶²	Deknuydt M...Catteau-Jonard S	30376853	2018
16	Ovarian steroid cell tumor, not otherwise specified. ⁶²	Sharma R...Sachdev R	30546150	2018
17	Sclerosing Stromal Tumor Mimicking a Pregnancy Luteoma: Case Report of a Diagnostically Challenging Entity Further Complicated by the Presence of Metastatic Signet Ring Cell Carcinoma From the Stomach. ⁶²	Uner M...Usubutun A	28633616	2017
18	Unilateral luteoma of the ovary in a pregnant Risso's dolphin (Grampus griseus). ⁶²	Nishina H...Yamate J	28845023	2017
19	Luteoma of Pregnancy Masquerading as Ectopic Pregnancy: Lessons Learnt. ⁶²	Rathore R...Nargotra N	30787804	2017
20	Pregnancy Luteoma in Ectopic Pregnancy: A Case Report. ⁶²	Brar RK...Ojha P	29062798	2017
21	Luteoma of Pregnancy. ⁶²	Khurana A...O'Boyle M	28081022	2017
22	Gestational Hyperandrogenism in Developmental Programming. ⁶²	Hakim C...Vyas AK	27967205	2017
23	Pregnancy luteoma: A rare case report. ⁶²	Verma V...Singh J	27857898	2016
24	A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. ⁶²	Bogdanou D...Bojunga J	27355981	2016
25	A puzzling ovarian tumour: pregnancy luteoma with diffuse endometriosis. ⁶²	Limaiem F...Mzabi S	28195267	2016
26	Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report. ⁶²	Rapisarda V...Zarbo G	27660728	2016
27	A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. ⁶²	Tanaka YO...Minami M	26726013	2016
28	Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads. ⁶²	Auguste A...Veitia RA	26362254	2015
29	[Clinicopathologic analysis of ovarian pregnancy luteoma]. ⁶²	Wang Y...Sun Y	26702533	2015
30	Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. ⁶²	Horta M...Cunha TM	26054417	2015
31	Stromal luteoma of the ovary: A rare ovarian pathology. ⁶²	Numanoglu C...Akbayir O	25140903	2015
32	Pregnancy luteoma followed with massive ascites and elevated CA125 after ovulation induction therapy: a case report and review of literatures. ⁶²	Wang Y...Huang LL	25785161	2015
33	Bilateral pregnancy luteoma: a case report. ⁶²	Nanda A...Pillai GR	25337317	2014
34	A case of ovarian steroid cell tumor, not otherwise specified, treated with surgery and gonadotropin releasing hormone agonist. ⁶²	Chung DH...Lee KB	25371891	2014
35	Pregnancy luteoma: a study of 20 cases on the occasion of the 50th anniversary of its description by Dr. William H. Sternberg, with an emphasis on the common presence of follicle-like spaces and their diagnostic implications. ⁶²	Burandt E...Young RH	24335664	2014
36	Luteoma of pregnancy associated with nearly complete virilization of genetically female twins. ⁶²	Wadzinski TL...Shoukri K	24126228	2014
37	Spontaneous ovarian hyperstimulation syndrome. ⁶²	Kasum M...Jezek D	23941020	2013
38	Late presentation of hyperandrogenism in pregnancy: clinical features and differential diagnosis. ⁶²	Das G...Rees DA	24616776	2013
39	Female pseudohermaphroditism associated with maternal steroid cell tumor, not otherwise specified of the ovary: a case report and literature review. ⁶²	Hasegawa K...Kuroda M	24597265	2013
40	Ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal hirsute woman. ⁶²	Souto SB...Carvalho D	23329192	2012
41	Immunohistochemical characterization of nonhuman primate ovarian sex cord-stromal tumors. ⁶²	Durkes A...Ramos-Vara J	22273575	2012
42	Fancf-deficient mice are prone to develop ovarian tumours. ⁶²	Bakker ST...te Riele H	21915857	2012
43	Virilisation during Pregnancy in a Patient with Metastatic Colorectal Cancer. ⁶²	Conway F...Thornton M	23097739	2012
44	Management of ovarian disease in pregnancy. ⁶²	Phelan N...Conway GS	22115171	2011
45	Hyperandrogenic states in pregnancy. ⁶²	Kanova N...Bicikova M	21114372	2011
46	Pregnancy luteomas: clinical presentations and management strategies. ⁶²	Masarie K...Balderston K	21144088	2010
47	Adnexal masses and malignancies of importance to the colorectal surgeon. ⁶²	Kline RC...Bazzett-Matabele LB	21629623	2010
48	Pseudoneoplastic lesions of the female genital tract. ⁶²	Medeiros F...Bell DA	20196667	2010
49	A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch. ⁶²	Ichimura R...Mitsumori K	19940389	2010
50	Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. ⁶²	Yamada S...Sasaguri Y	19883437	2009

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Genes for Luteoma

Genes related to Luteoma (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	18.65	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10664233 10726707
2	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	10.36	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	7.43	GeneCards inferred via : Publications (show sections)
4	EPPIN	Epididymal Peptidase Inhibitor	Protein Coding	7.28	DISEASES inferred ¹⁴ ¹⁴
5	CALB2	Calbindin 2	Protein Coding	6.03	DISEASES inferred ¹⁴
6	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	5.87	Novoseek inferred ⁵³	1328353
7	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	5.67	DISEASES inferred ¹⁴
8	FOXL2	Forkhead Box L2	Protein Coding	5.55	DISEASES inferred ¹⁴
9	SHBG	Sex Hormone Binding Globulin	Protein Coding	5.52	DISEASES inferred ¹⁴
10	AMHR2	Anti-Mullerian Hormone Receptor Type 2	Protein Coding	5.44	DISEASES inferred ¹⁴
11	AMH	Anti-Mullerian Hormone	Protein Coding	5.27	DISEASES inferred ¹⁴
12	MLANA	Melan-A	Protein Coding	5.2	DISEASES inferred ¹⁴
13	STAR	Steroidogenic Acute Regulatory Protein	Protein Coding	5.12	DISEASES inferred ¹⁴

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Variations for Luteoma

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Expression for Luteoma

Search GEO for disease gene expression data for Luteoma.

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Pathways for Luteoma

Pathways related to Luteoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of steroids ⁶⁶ Show member pathways Activation of gene expression by SREBF (SREBP) ⁶⁶ allopregnanolone biosynthesis ⁶¹ androgen biosynthesis ⁶¹ Cholesterol synthesis disorders ⁷⁴ Defective CYP17A1 causes AH5 ⁶⁶ Regulation of cholesterol biosynthesis by SREBP (SREBF) ⁶⁶ Sterol regulatory element-binding proteins (SREBP) signaling ⁷⁴ Vitamin D (calciferol) metabolism ⁶⁶	12.12	STAR CYP21A2 CYP19A1 CGA
2	Metabolism of steroid hormones ⁶⁶ Show member pathways Androgen biosynthesis ⁶⁶ Defective CYP11A1 causes AICSR ⁶⁶ Defective CYP11B1 causes AH4 ⁶⁶ Defective CYP21A2 causes AH3 ⁶⁶ Electron transport from NADPH to Ferredoxin ⁶⁶ Estrogen biosynthesis ⁶⁶ Glucocorticoid and Mineralcorticoid Metabolism ⁷⁴ Glucocorticoid biosynthesis ⁶⁶ Mineralocorticoid biosynthesis ⁶⁶ Pregnenolone biosynthesis ⁶⁶	11.24	STAR CYP21A2 CYP19A1 CGA
3	Syndecan-2-mediated signaling events ⁶¹	11.01	FGFR3 FGFR2
4	Metabolic disorders of biological oxidation enzymes ⁶⁶	10.99	CYP21A2 CYP19A1
5	Syndecan-1-mediated signaling events ⁶¹	10.91	FGFR3 FGFR2
6	FGF23 signaling in hypophosphatemic rickets and related disorders ⁷⁴	10.75	FGFR3 FGFR2
7	Syndecan-3-mediated signaling events ⁶¹	10.67	FGFR3 FGFR2
8	Mammalian disorder of sexual development ⁷⁴ Show member pathways Somatic sex determination ⁷⁴ Transcriptional regulation of testis differentiation ⁶⁶	10.61	FOXL2 FGFR2 AMHR2 AMH
9	MAP3K1 role in promoting and blocking gonadal determination ⁷⁴	10.53	FOXL2 FGFR2
10	ALK2 signaling events ⁶¹	10.11	AMHR2 AMH

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GO Terms for Luteoma

Biological processes related to Luteoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	uterus development	GO:0060065	9.76	FOXL2 CYP19A1
2	pathway-restricted SMAD protein phosphorylation	GO:0060389	9.73	AMHR2 AMH
3	steroid biosynthetic process	GO:0006694	9.73	STAR CYP21A2 CYP19A1
4	endochondral bone growth	GO:0003416	9.67	FGFR3 FGFR2
5	positive regulation of phospholipase activity	GO:0010518	9.62	FGFR3 FGFR2
6	Mullerian duct regression	GO:0001880	9.46	AMHR2 AMH
7	gonad development	GO:0008406	9.4	CGA AMH
8	female gonad development	GO:0008585	9.02	FOXL2 CYP19A1 AMHR2
9	cellular response to endogenous stimulus	GO:0071495	8.96	FGFR3 FGFR2

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	fibroblast growth factor receptor activity	GO:0005007	8.92	FGFR3 FGFR2

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Sources for Luteoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LTM002 MIFTS: 34	Luteoma Categories: Cancer diseases, Endocrine diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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