MCID: LTM002
MIFTS: 31

Luteoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Luteoma

MalaCards integrated aliases for Luteoma:

Name: Luteoma 12 54 15 70
Leuteoma of Pregnancy 12
Luteoma of Pregnancy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7880
NCIt 50 C40445
UMLS 70 C0024167 C1517842

Summaries for Luteoma

Disease Ontology : 12 An ovarian benign neoplasm characterized by solid proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium.

MalaCards based summary : Luteoma, also known as leuteoma of pregnancy, is related to hyperandrogenism and acne. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Signaling by FGFR2 and Metabolism of steroid hormones. Affiliated tissues include ovary, spleen and uterus.

Wikipedia : 73 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

Related Diseases for Luteoma

Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 hyperandrogenism 30.0 SHBG CYP21A2 CYP19A1
2 acne 30.0 SHBG FGFR2 CYP21A2
3 antley-bixler syndrome 29.9 FGFR3 FGFR2 CYP21A2 CYP19A1
4 acanthosis nigricans 29.7 SHBG FGFR3 FGFR2
5 pseudohermaphroditism 29.7 FSHR EPPIN CYP21A2 CYP19A1
6 precocious puberty 29.6 FSHR CYP21A2 CYP19A1
7 adrenal cortical carcinoma 29.5 EPPIN CYP21A2 CYP19A1 CALB2
8 cryptorchidism, unilateral or bilateral 28.8 SHBG FSHR EPPIN CYP19A1 CGA
9 ovarian disease 28.4 SHBG FSHR FOXL2 EPPIN CYP19A1 CGA
10 disorder of sexual development 28.3 SHBG FSHR FOXL2 EPPIN CYP21A2 CYP19A1
11 fgfr craniosynostosis syndromes 10.3 FGFR3 FGFR2
12 hemifacial hyperplasia 10.3 FGFR3 FGFR2
13 cytochrome p450 oxidoreductase deficiency 10.3 FGFR2 CYP21A2
14 plagiocephaly 10.3 FGFR3 FGFR2
15 syndromic craniosynostosis 10.2 FGFR3 FGFR2
16 testicular spermatocytic seminoma 10.2 FGFR3 FGFR2
17 adrenal rest tumor 10.2 EPPIN CYP21A2
18 hypertelorism, microtia, facial clefting syndrome 10.2 FGFR3 FGFR2
19 dacryocystocele 10.2 FGFR3 FGFR2
20 chronic inflammation of lacrimal passage 10.2 FGFR3 FGFR2
21 achondroplasia, severe, with developmental delay and acanthosis nigricans 10.2 FGFR3 FGFR2
22 wolffian duct adenocarcinoma 10.2 FGFR2 CALB2
23 acanthoma 10.2 FGFR3 FGFR2
24 beare-stevenson cutis gyrata syndrome 10.2 FGFR3 FGFR2
25 transsexualism 10.2 CYP21A2 CYP19A1
26 osteoglophonic dysplasia 10.2 FGFR3 FGFR2
27 muenke syndrome 10.2 FGFR3 FGFR2
28 thanatophoric dysplasia, type i 10.2 FGFR3 FGFR2
29 ovarian endometrioid stromal sarcoma 10.2 CYP19A1 CALB2
30 cervical keratinizing squamous cell carcinoma 10.2 SHBG FGFR2
31 hypochondroplasia 10.1 FGFR3 FGFR2
32 lipoid congenital adrenal hyperplasia 10.1
33 ovary sarcoma 10.1 CYP19A1 CALB2
34 radioulnar synostosis 10.1 FGFR3 FGFR2
35 steroid inherited metabolic disorder 10.1 SHBG CYP21A2
36 oocyte maturation defect 1 10.1 CYP19A1 CGA
37 skin tag 10.1 SHBG FGFR2
38 prostatic hypertrophy 10.1 EPPIN CYP19A1
39 hypoactive sexual desire disorder 10.1 SHBG CYP19A1
40 deafness, autosomal recessive 71 10.1 FGFR3 FGFR2 CALB2
41 prostatic cyst 10.1 FSHR EPPIN
42 androgen insensitivity, partial 10.1 SHBG CYP19A1
43 pelvic varices 10.0 SHBG EPPIN
44 leydig cell tumor 10.0 CYP21A2 CYP19A1 CALB2
45 sertoli cell tumor 10.0 CYP19A1 CALB2
46 craniosynostosis 1 10.0 FGFR3 FGFR2
47 androgenic alopecia 10.0 SHBG CYP19A1
48 pigmentation disease 10.0 SHBG FGFR3 FGFR2
49 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.0
50 ectopic pregnancy 10.0

Graphical network of the top 20 diseases related to Luteoma:



Diseases related to Luteoma

Symptoms & Phenotypes for Luteoma

Drugs & Therapeutics for Luteoma

Search Clinical Trials , NIH Clinical Center for Luteoma

Genetic Tests for Luteoma

Anatomical Context for Luteoma

MalaCards organs/tissues related to Luteoma:

40
Ovary, Spleen, Uterus, Pituitary

Publications for Luteoma

Articles related to Luteoma:

(show top 50) (show all 180)
# Title Authors PMID Year
1
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. 54 61
10726707 2000
2
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. 61 54
10664233 2000
3
[Luteinized cystic hyperplasia of the ovaries during pregnancy. A case report]. 61 54
1328353 1992
4
Incidental Finding of Bilateral Ovarian Adrenal Rest Tumor in a Patient With Congenital Adrenal Hyperplasia: A Case Report and Brief Review. 61
33433255 2021
5
Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch. 61
32778114 2020
6
An Access to Androgen Excess: The Ovary Unregulated. 61
31562730 2019
7
Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma. 61
29257039 2019
8
Recurrent maternal virilization during pregnancy in patients with PCOS: two clinical cases. 61
30376853 2018
9
Ovarian steroid cell tumor, not otherwise specified. 61
30546150 2018
10
Sclerosing Stromal Tumor Mimicking a Pregnancy Luteoma: Case Report of a Diagnostically Challenging Entity Further Complicated by the Presence of Metastatic Signet Ring Cell Carcinoma From the Stomach. 61
28633616 2017
11
Unilateral luteoma of the ovary in a pregnant Risso's dolphin (Grampus griseus). 61
28845023 2017
12
Luteoma of Pregnancy Masquerading as Ectopic Pregnancy: Lessons Learnt. 61
30787804 2017
13
Pregnancy Luteoma in Ectopic Pregnancy: A Case Report. 61
29062798 2017
14
Luteoma of Pregnancy. 61
28081022 2017
15
Gestational Hyperandrogenism in Developmental Programming. 61
27967205 2017
16
Pregnancy luteoma: A rare case report. 61
27857898 2016
17
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. 61
27355981 2016
18
A puzzling ovarian tumour: pregnancy luteoma with diffuse endometriosis. 61
28195267 2016
19
A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. 61
26726013 2016
20
Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report. 61
27660728 2016
21
Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads. 61
26362254 2015
22
[Clinicopathologic analysis of ovarian pregnancy luteoma]. 61
26702533 2015
23
Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. 61
26054417 2015
24
Stromal luteoma of the ovary: A rare ovarian pathology. 61
25140903 2015
25
Pregnancy luteoma followed with massive ascites and elevated CA125 after ovulation induction therapy: a case report and review of literatures. 61
25785161 2015
26
Bilateral pregnancy luteoma: a case report. 61
25337317 2014
27
A case of ovarian steroid cell tumor, not otherwise specified, treated with surgery and gonadotropin releasing hormone agonist. 61
25371891 2014
28
Pregnancy luteoma: a study of 20 cases on the occasion of the 50th anniversary of its description by Dr. William H. Sternberg, with an emphasis on the common presence of follicle-like spaces and their diagnostic implications. 61
24335664 2014
29
Luteoma of pregnancy associated with nearly complete virilization of genetically female twins. 61
24126228 2014
30
Spontaneous ovarian hyperstimulation syndrome. 61
23941020 2013
31
Female pseudohermaphroditism associated with maternal steroid cell tumor, not otherwise specified of the ovary: a case report and literature review. 61
24597265 2013
32
Late presentation of hyperandrogenism in pregnancy: clinical features and differential diagnosis. 61
24616776 2013
33
Ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal hirsute woman. 61
23329192 2012
34
Immunohistochemical characterization of nonhuman primate ovarian sex cord-stromal tumors. 61
22273575 2012
35
Virilisation during Pregnancy in a Patient with Metastatic Colorectal Cancer. 61
23097739 2012
36
Fancf-deficient mice are prone to develop ovarian tumours. 61
21915857 2012
37
Management of ovarian disease in pregnancy. 61
22115171 2011
38
Hyperandrogenic states in pregnancy. 61
21114372 2011
39
Pregnancy luteomas: clinical presentations and management strategies. 61
21144088 2010
40
Adnexal masses and malignancies of importance to the colorectal surgeon. 61
21629623 2010
41
Pseudoneoplastic lesions of the female genital tract. 61
20196667 2010
42
A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch. 61
19940389 2010
43
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. 61
19883437 2009
44
Luteoma-induced fetal virilization. 61
20149054 2009
45
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. 61
19110243 2009
46
SRY gene increases the risk of developing gonadoblastoma and/or nontumoral gonadal lesions in Turner syndrome. 61
19188812 2009
47
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. 61
19243065 2009
48
Maternal virilization due to luteoma associated with delayed lactation. 61
18635167 2008
49
Clinical implications of the detection of Y-chromosome mosaicism in Turner's syndrome: report of 3 cases. 61
18295215 2008
50
[Maternal virilization due to mucinous ovarian tumour: a case report]. 61
18462892 2008

Variations for Luteoma

Expression for Luteoma

Search GEO for disease gene expression data for Luteoma.

Pathways for Luteoma

GO Terms for Luteoma

Cellular components related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 FSHR FGFR3 FGFR2 EPPIN
2 receptor complex GO:0043235 8.8 FSHR FGFR3 FGFR2

Biological processes related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.54 FSHR FGFR3 FGFR2
2 ovarian follicle development GO:0001541 9.4 FSHR FOXL2
3 bone morphogenesis GO:0060349 9.32 FGFR3 FGFR2
4 sterol metabolic process GO:0016125 9.26 CYP21A2 CYP19A1
5 female gonad development GO:0008585 9.16 FSHR CYP19A1
6 positive regulation of phospholipase activity GO:0010518 8.96 FGFR3 FGFR2
7 endochondral bone growth GO:0003416 8.62 FGFR3 FGFR2

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hydroxylase activity GO:0008395 9.26 CYP21A2 CYP19A1
2 steroid binding GO:0005496 9.16 SHBG CYP21A2
3 fibroblast growth factor binding GO:0017134 8.96 FGFR3 FGFR2
4 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR3 FGFR2

Sources for Luteoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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