MCID: LTM002
MIFTS: 34

Luteoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
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Aliases & Classifications for Luteoma

MalaCards integrated aliases for Luteoma:

Name: Luteoma 11 53 43 14 71 75
Leuteoma of Pregnancy 11
Luteoma of Pregnancy 11

Classifications:



External Ids:

Disease Ontology 11 DOID:7880
MeSH 43 D018311
NCIt 49 C40445
UMLS 71 C0024167 C1517842

Summaries for Luteoma

Disease Ontology: 11 An ovarian benign neoplasm characterized by solid proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium.

MalaCards based summary: Luteoma, also known as leuteoma of pregnancy, is related to hypertelorism, microtia, facial clefting syndrome and cytochrome p450 oxidoreductase deficiency. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metabolism of steroids and Metabolism of steroid hormones. Affiliated tissues include ovary, uterus and spleen, and related phenotypes are growth/size/body region and no phenotypic analysis

Wikipedia: 75 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

Related Diseases for Luteoma

Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 hypertelorism, microtia, facial clefting syndrome 30.3 FGFR3 FGFR2
2 cytochrome p450 oxidoreductase deficiency 30.3 CYP21A2 CYP19A1
3 acne 30.2 SHBG CYP21A2 CYP19A1
4 antley-bixler syndrome 29.9 FGFR3 FGFR2 CYP21A2 CYP19A1
5 acanthosis nigricans 29.8 SHBG FGFR3 FGFR2
6 hyperandrogenism 29.7 SHBG CYP21A2 CYP19A1 AMH
7 amenorrhea 29.6 SHBG FOXL2 CYP19A1
8 endometriosis 29.4 STAR CYP19A1 CGA CALB2
9 lipoid congenital adrenal hyperplasia 29.0 STAR SHBG CYP21A2 CYP19A1 AMHR2 AMH
10 polycystic ovary syndrome 28.9 STAR SHBG CYP21A2 CYP19A1 CGA AMH
11 pseudohermaphroditism 28.7 STAR FOXL2 EPPIN CYP21A2 CYP19A1 AMHR2
12 adrenal cortical carcinoma 28.7 STAR MLANA EPPIN CYP21A2 CYP19A1 CALB2
13 ovarian disease 28.5 SHBG FOXL2 EPPIN CYP19A1 CGA AMHR2
14 disorder of sexual development 27.8 STAR SHBG FOXL2 FGFR2 EPPIN CYP21A2
15 cryptorchidism, unilateral or bilateral 27.7 STAR SHBG FOXL2 EPPIN CYP21A2 CYP19A1
16 hemifacial hyperplasia 10.3 FGFR3 FGFR2
17 plagiocephaly 10.3 FGFR3 FGFR2
18 testicular spermatocytic seminoma 10.2 FGFR3 FGFR2
19 adrenal rest tumor 10.2 EPPIN CYP21A2
20 achondroplasia, severe, with developmental delay and acanthosis nigricans 10.2 FGFR3 FGFR2
21 crouzon syndrome with acanthosis nigricans 10.2 FGFR3 FGFR2
22 congenital disorder of glycosylation, type iim 10.2 FGFR3 FGFR2
23 beare-stevenson cutis gyrata syndrome 10.2 FGFR3 FGFR2
24 peritoneal benign neoplasm 10.2 CYP19A1 CALB2
25 cervical keratinizing squamous cell carcinoma 10.2 SHBG FGFR2
26 osteoglophonic dysplasia 10.2 FGFR3 FGFR2
27 mixed germ cell-sex cord neoplasm 10.2 FOXL2 CALB2
28 muenke syndrome 10.2 FGFR3 FGFR2
29 spermatocele 10.1 CALB2 AMHR2
30 thanatophoric dysplasia, type i 10.1 FGFR3 FGFR2
31 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.1 STAR CYP21A2
32 prostatic hypertrophy 10.1 SHBG EPPIN
33 corticosterone methyloxidase type i deficiency 10.1 STAR CYP21A2
34 ectopic pregnancy 10.1
35 hydrocele 10.1 EPPIN CGA CALB2
36 pigmentation disease 10.0 SHBG FGFR3 FGFR2
37 tuberculous epididymitis 10.0 CALB2 AMH
38 androgenic alopecia 10.0 SHBG CYP19A1
39 subserous uterine fibroid 10.0 CYP19A1 AMH
40 ovarian serous cystadenofibroma 10.0 CALB2 AMH
41 ovarian serous adenofibroma 10.0 CALB2 AMH
42 cystic teratoma 10.0 CALB2 AMH
43 alopecia, androgenetic, 1 10.0 SHBG CYP21A2 CYP19A1
44 adrenal cortical hypofunction 10.0 STAR CYP21A2
45 ovarian germ cell cancer 10.0 CALB2 AMH
46 adrenal hypoplasia, congenital 10.0 STAR EPPIN CYP21A2
47 renal cell carcinoma, nonpapillary 10.0
48 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.0
49 endometrial hyperplasia 10.0
50 pre-eclampsia 10.0

Graphical network of the top 20 diseases related to Luteoma:



Diseases related to Luteoma

Symptoms & Phenotypes for Luteoma

MGI Mouse Phenotypes related to Luteoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.96 AMH AMHR2 CGA CYP19A1 CYP21A2 EPPIN
2 no phenotypic analysis MP:0003012 9.8 AMH AMHR2 FGFR2 FGFR3 FOXL2 MLANA
3 endocrine/exocrine gland MP:0005379 9.76 AMH AMHR2 CGA CYP19A1 EPPIN FGFR2
4 reproductive system MP:0005389 9.61 AMH AMHR2 CGA CYP19A1 EPPIN FGFR2
5 integument MP:0010771 9.17 AMHR2 CYP19A1 CYP21A2 EPPIN FGFR2 FGFR3

Drugs & Therapeutics for Luteoma

Search Clinical Trials, NIH Clinical Center for Luteoma

Cochrane evidence based reviews: luteoma

Genetic Tests for Luteoma

Anatomical Context for Luteoma

Organs/tissues related to Luteoma:

MalaCards : Ovary, Uterus, Spleen, Pituitary, Breast, Skin

Publications for Luteoma

Articles related to Luteoma:

(show top 50) (show all 187)
# Title Authors PMID Year
1
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. 53 62
10726707 2000
2
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. 53 62
10664233 2000
3
[Luteinized cystic hyperplasia of the ovaries during pregnancy. A case report]. 53 62
1328353 1992
4
Clinicopathologic features of pregnancy luteoma. 62
35212399 2022
5
A case of excision of ovarian torsion necrosis due to luteoma in a female who conceived a twin pregnancy through in vitro fertilization misdiagnosed with acute appendicitis. 62
36002954 2022
6
Luteoma of Pregnancy Presenting as Ruptured Ectopic Pregnancy: A Case Report. 62
36465744 2022
7
Luteoma of Pregnancy with Uterine Leiomyoma as a Diagnostic Challenge and Mimicker of Ovarian Malignancy: A Rare Case From Rural India. 62
36045881 2022
8
A RETROSPECTIVE SURVEY OF NEOPLASIA IN MANAGED GIRAFFES (GIRAFFA CAMELOPARDALIS). 62
33827195 2021
9
Incidental Finding of Bilateral Ovarian Adrenal Rest Tumor in a Patient With Congenital Adrenal Hyperplasia: A Case Report and Brief Review. 62
33433255 2021
10
Hirsutism Caused by Pregnancy Luteoma in a Low-Resource Setting: A Case Report and Literature Review. 62
33833884 2021
11
Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch. 62
32778114 2020
12
Unusual Course of Acne Conglobata as a Skin Manifestation due to Bilateral Luteoma of Pregnancy. 62
33911699 2019
13
An Access to Androgen Excess: The Ovary Unregulated. 62
31562730 2019
14
Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma. 62
29257039 2019
15
Recurrent maternal virilization during pregnancy in patients with PCOS: two clinical cases. 62
30376853 2018
16
Ovarian steroid cell tumor, not otherwise specified. 62
30546150 2018
17
Sclerosing Stromal Tumor Mimicking a Pregnancy Luteoma: Case Report of a Diagnostically Challenging Entity Further Complicated by the Presence of Metastatic Signet Ring Cell Carcinoma From the Stomach. 62
28633616 2017
18
Unilateral luteoma of the ovary in a pregnant Risso's dolphin (Grampus griseus). 62
28845023 2017
19
Luteoma of Pregnancy Masquerading as Ectopic Pregnancy: Lessons Learnt. 62
30787804 2017
20
Pregnancy Luteoma in Ectopic Pregnancy: A Case Report. 62
29062798 2017
21
Luteoma of Pregnancy. 62
28081022 2017
22
Gestational Hyperandrogenism in Developmental Programming. 62
27967205 2017
23
Pregnancy luteoma: A rare case report. 62
27857898 2016
24
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. 62
27355981 2016
25
A puzzling ovarian tumour: pregnancy luteoma with diffuse endometriosis. 62
28195267 2016
26
Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report. 62
27660728 2016
27
A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. 62
26726013 2016
28
Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads. 62
26362254 2015
29
[Clinicopathologic analysis of ovarian pregnancy luteoma]. 62
26702533 2015
30
Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. 62
26054417 2015
31
Stromal luteoma of the ovary: A rare ovarian pathology. 62
25140903 2015
32
Pregnancy luteoma followed with massive ascites and elevated CA125 after ovulation induction therapy: a case report and review of literatures. 62
25785161 2015
33
Bilateral pregnancy luteoma: a case report. 62
25337317 2014
34
A case of ovarian steroid cell tumor, not otherwise specified, treated with surgery and gonadotropin releasing hormone agonist. 62
25371891 2014
35
Pregnancy luteoma: a study of 20 cases on the occasion of the 50th anniversary of its description by Dr. William H. Sternberg, with an emphasis on the common presence of follicle-like spaces and their diagnostic implications. 62
24335664 2014
36
Luteoma of pregnancy associated with nearly complete virilization of genetically female twins. 62
24126228 2014
37
Spontaneous ovarian hyperstimulation syndrome. 62
23941020 2013
38
Late presentation of hyperandrogenism in pregnancy: clinical features and differential diagnosis. 62
24616776 2013
39
Female pseudohermaphroditism associated with maternal steroid cell tumor, not otherwise specified of the ovary: a case report and literature review. 62
24597265 2013
40
Ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal hirsute woman. 62
23329192 2012
41
Immunohistochemical characterization of nonhuman primate ovarian sex cord-stromal tumors. 62
22273575 2012
42
Fancf-deficient mice are prone to develop ovarian tumours. 62
21915857 2012
43
Virilisation during Pregnancy in a Patient with Metastatic Colorectal Cancer. 62
23097739 2012
44
Management of ovarian disease in pregnancy. 62
22115171 2011
45
Hyperandrogenic states in pregnancy. 62
21114372 2011
46
Pregnancy luteomas: clinical presentations and management strategies. 62
21144088 2010
47
Adnexal masses and malignancies of importance to the colorectal surgeon. 62
21629623 2010
48
Pseudoneoplastic lesions of the female genital tract. 62
20196667 2010
49
A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch. 62
19940389 2010
50
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. 62
19883437 2009

Variations for Luteoma

Expression for Luteoma

Search GEO for disease gene expression data for Luteoma.

Pathways for Luteoma

Pathways related to Luteoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.12 STAR CYP21A2 CYP19A1 CGA
2
Show member pathways
11.24 STAR CYP21A2 CYP19A1 CGA
3 11.01 FGFR3 FGFR2
4 10.99 CYP21A2 CYP19A1
5 10.91 FGFR3 FGFR2
7 10.67 FGFR3 FGFR2
8
Show member pathways
10.61 FOXL2 FGFR2 AMHR2 AMH
9 10.53 FOXL2 FGFR2
10 10.11 AMHR2 AMH

GO Terms for Luteoma

Biological processes related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 uterus development GO:0060065 9.76 FOXL2 CYP19A1
2 pathway-restricted SMAD protein phosphorylation GO:0060389 9.73 AMHR2 AMH
3 steroid biosynthetic process GO:0006694 9.73 STAR CYP21A2 CYP19A1
4 endochondral bone growth GO:0003416 9.67 FGFR3 FGFR2
5 positive regulation of phospholipase activity GO:0010518 9.62 FGFR3 FGFR2
6 Mullerian duct regression GO:0001880 9.46 AMHR2 AMH
7 gonad development GO:0008406 9.4 CGA AMH
8 female gonad development GO:0008585 9.02 FOXL2 CYP19A1 AMHR2
9 cellular response to endogenous stimulus GO:0071495 8.96 FGFR3 FGFR2

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor activity GO:0005007 8.92 FGFR3 FGFR2

Sources for Luteoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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