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MCID: LTM002
MIFTS: 32

Luteoma

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Luteoma

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MalaCards integrated aliases for Luteoma:

Name: Luteoma 12 54 15 71
Leuteoma of Pregnancy 12
Luteoma of Pregnancy 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7880
NCIt 49 C40445
UMLS 71 C0024167 C1517842
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Summaries for Luteoma

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Disease Ontology : 12 An ovarian benign neoplasm characterized by solid proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium.

MalaCards based summary : Luteoma, also known as leuteoma of pregnancy, is related to adrenal cortical carcinoma and antley-bixler syndrome. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metabolism of steroid hormones and Ovarian steroidogenesis. Affiliated tissues include ovary, spleen and breast, and related phenotypes are nervous system and reproductive system

Wikipedia : 74 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

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Related Diseases for Luteoma

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Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 adrenal cortical carcinoma 30.3 EPPIN CYP21A2 CALB2
2 antley-bixler syndrome 30.2 FGFR3 FGFR2 CYP21A2 CYP19A1
3 acanthosis nigricans 30.1 SHBG FGFR3 FGFR2
4 precocious puberty 30.0 GNRH1 CYP21A2 CYP19A1
5 pseudohermaphroditism 30.0 FSHR EPPIN CYP21A2 CYP19A1
6 lipoid congenital adrenal hyperplasia 30.0 SHBG GNRH1 CYP21A2 CYP19A1
7 hyperandrogenism 30.0 SHBG GNRH1 CYP21A2 CYP19A1
8 endometriosis 28.9 GNRH1 FSHR CYP19A1 CGA CALB2
9 endometrial cancer 28.8 SHBG GNRH1 FGFR2 CYP19A1 CALB2
10 polycystic ovary syndrome 28.5 SHBG GNRH1 FSHR CYP21A2 CYP19A1 CGA
11 cryptorchidism, unilateral or bilateral 28.4 SHBG GNRH1 FSHR EPPIN CYP19A1 CGA
12 ovarian disease 28.0 SHBG GNRH1 FSHR FOXL2 EPPIN CYP19A1
13 disorders of sexual development 27.9 SHBG GNRH1 FSHR FOXL2 EPPIN CYP21A2
14 fgfr craniosynostosis syndromes 10.4 FGFR3 FGFR2
15 hemifacial hyperplasia 10.4 FGFR3 FGFR2
16 cytochrome p450 oxidoreductase deficiency 10.4 FGFR2 CYP21A2
17 plagiocephaly 10.4 FGFR3 FGFR2
18 syndromic craniosynostosis 10.4 FGFR3 FGFR2
19 testicular spermatocytic seminoma 10.4 FGFR3 FGFR2
20 adrenal rest tumor 10.4 EPPIN CYP21A2
21 hypertelorism, microtia, facial clefting syndrome 10.3 FGFR3 FGFR2
22 achondroplasia, severe, with developmental delay and acanthosis nigricans 10.3 FGFR3 FGFR2
23 dacryocystocele 10.3 FGFR3 FGFR2
24 wolffian duct adenocarcinoma 10.3 FGFR2 CALB2
25 chronic inflammation of lacrimal passage 10.3 FGFR3 FGFR2
26 acanthoma 10.3 FGFR3 FGFR2
27 beare-stevenson cutis gyrata syndrome 10.3 FGFR3 FGFR2
28 aplasia of lacrimal and salivary glands 10.3 FGFR3 FGFR2
29 transsexualism 10.3 CYP21A2 CYP19A1
30 osteoglophonic dysplasia 10.3 FGFR3 FGFR2
31 muenke syndrome 10.3 FGFR3 FGFR2
32 ovarian endometrioid stromal sarcoma 10.2 CYP19A1 CALB2
33 oocyte maturation defect 1 10.2 CYP19A1 CGA
34 neurofibromatosis, type ii 10.2
35 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.2
36 ectopic pregnancy 10.2
37 endometrial hyperplasia 10.2
38 pre-eclampsia 10.2
39 postmenopausal atrophic vaginitis 10.2 SHBG CYP19A1
40 prostatic cyst 10.2 FSHR EPPIN
41 cervical keratinizing squamous cell carcinoma 10.2 SHBG FGFR2
42 androgen insensitivity, partial 10.2 SHBG CYP19A1
43 atrophy of prostate 10.2 GNRH1 EPPIN
44 peritoneal benign neoplasm 10.2 GNRH1 CALB2
45 thanatophoric dysplasia, type i 10.2 FGFR3 FGFR2
46 hypoactive sexual desire disorder 10.2 SHBG CYP19A1
47 skin tag 10.2 SHBG FGFR2
48 hypogonadotropic hypogonadism 23 without anosmia 10.2 GNRH1 EPPIN
49 exophthalmos 10.1 FGFR3 FGFR2
50 benign peritoneal mesothelioma 10.1 GNRH1 CALB2

Graphical network of the top 20 diseases related to Luteoma:



Diseases related to Luteoma
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Symptoms & Phenotypes for Luteoma

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MGI Mouse Phenotypes related to Luteoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.56 CALB2 CGA CYP19A1 ECEL1 FGFR2 FGFR3
2 reproductive system MP:0005389 9.17 CGA CYP19A1 FGFR2 FGFR3 FOXL2 FSHR
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Drugs & Therapeutics for Luteoma

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Search Clinical Trials , NIH Clinical Center for Luteoma

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Genetic Tests for Luteoma

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Anatomical Context for Luteoma

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MalaCards organs/tissues related to Luteoma:

40
Ovary, Spleen, Breast, Uterus, Pituitary
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Publications for Luteoma

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Articles related to Luteoma:

(show top 50) (show all 177)
# Title Authors PMID Year
1
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. 61 54
10726707 2000
2
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. 61 54
10664233 2000
3
[Luteinized cystic hyperplasia of the ovaries during pregnancy. A case report]. 54 61
1328353 1992
4
An Access to Androgen Excess: The Ovary Unregulated. 61
31562730 2019
5
Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma. 61
29257039 2019
6
Recurrent maternal virilization during pregnancy in patients with PCOS: two clinical cases. 61
30376853 2018
7
Ovarian steroid cell tumor, not otherwise specified. 61
30546150 2018
8
Sclerosing Stromal Tumor Mimicking a Pregnancy Luteoma: Case Report of a Diagnostically Challenging Entity Further Complicated by the Presence of Metastatic Signet Ring Cell Carcinoma From the Stomach. 61
28633616 2017
9
Unilateral luteoma of the ovary in a pregnant Risso's dolphin (Grampus griseus). 61
28845023 2017
10
Luteoma of Pregnancy Masquerading as Ectopic Pregnancy: Lessons Learnt. 61
30787804 2017
11
Pregnancy Luteoma in Ectopic Pregnancy: A Case Report. 61
29062798 2017
12
Luteoma of Pregnancy. 61
28081022 2017
13
Gestational Hyperandrogenism in Developmental Programming. 61
27967205 2017
14
Pregnancy luteoma: A rare case report. 61
27857898 2016
15
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. 61
27355981 2016
16
A puzzling ovarian tumour: pregnancy luteoma with diffuse endometriosis. 61
28195267 2016
17
Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report. 61
27660728 2016
18
A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. 61
26726013 2016
19
Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads. 61
26362254 2015
20
[Clinicopathologic analysis of ovarian pregnancy luteoma]. 61
26702533 2015
21
Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. 61
26054417 2015
22
Stromal luteoma of the ovary: A rare ovarian pathology. 61
25140903 2015
23
Pregnancy luteoma followed with massive ascites and elevated CA125 after ovulation induction therapy: a case report and review of literatures. 61
25785161 2015
24
Bilateral pregnancy luteoma: a case report. 61
25337317 2014
25
A case of ovarian steroid cell tumor, not otherwise specified, treated with surgery and gonadotropin releasing hormone agonist. 61
25371891 2014
26
Luteoma of pregnancy associated with nearly complete virilization of genetically female twins. 61
24126228 2014
27
Pregnancy luteoma: a study of 20 cases on the occasion of the 50th anniversary of its description by Dr. William H. Sternberg, with an emphasis on the common presence of follicle-like spaces and their diagnostic implications. 61
24335664 2014
28
Spontaneous ovarian hyperstimulation syndrome. 61
23941020 2013
29
Late presentation of hyperandrogenism in pregnancy: clinical features and differential diagnosis. 61
24616776 2013
30
Female pseudohermaphroditism associated with maternal steroid cell tumor, not otherwise specified of the ovary: a case report and literature review. 61
24597265 2013
31
Ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal hirsute woman. 61
23329192 2012
32
Immunohistochemical characterization of nonhuman primate ovarian sex cord-stromal tumors. 61
22273575 2012
33
Fancf-deficient mice are prone to develop ovarian tumours. 61
21915857 2012
34
Virilisation during Pregnancy in a Patient with Metastatic Colorectal Cancer. 61
23097739 2012
35
Management of ovarian disease in pregnancy. 61
22115171 2011
36
Hyperandrogenic states in pregnancy. 61
21114372 2011
37
Pregnancy luteomas: clinical presentations and management strategies. 61
21144088 2010
38
Adnexal masses and malignancies of importance to the colorectal surgeon. 61
21629623 2010
39
Pseudoneoplastic lesions of the female genital tract. 61
20196667 2010
40
A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch. 61
19940389 2010
41
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. 61
19883437 2009
42
Luteoma-induced fetal virilization. 61
20149054 2009
43
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. 61
19110243 2009
44
SRY gene increases the risk of developing gonadoblastoma and/or nontumoral gonadal lesions in Turner syndrome. 61
19188812 2009
45
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. 61
19243065 2009
46
Maternal virilization due to luteoma associated with delayed lactation. 61
18635167 2008
47
Clinical implications of the detection of Y-chromosome mosaicism in Turner's syndrome: report of 3 cases. 61
18295215 2008
48
[Maternal virilization due to mucinous ovarian tumour: a case report]. 61
18462892 2008
49
Ovarian stromal luteoma in a patient with endometrial carcinoma. 61
18412799 2008
50
Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. 61
18362993 2008
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Variations for Luteoma

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Expression for Luteoma

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Search GEO for disease gene expression data for Luteoma.
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Pathways for Luteoma

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Pathways related to Luteoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Metabolism of steroid hormones 65
Show member pathways
 11.38 CYP21A2 CYP19A1 CGA
2
Ovarian steroidogenesis 36
11.04 FSHR CYP19A1 CGA
3
Ovarian Infertility Genes 1
10.87 FSHR CYP19A1
4
Nongenotropic Androgen signaling 1
10.58 SHBG GNRH1
5
Follicle Stimulating Hormone (FSH) signaling pathway 1
10.56 FSHR CYP19A1 CGA
6
Hormone ligand-binding receptors 65
9.91 GNRH1 FSHR CGA
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GO Terms for Luteoma

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Cellular components related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 FSHR FGFR3 FGFR2

Biological processes related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.61 FSHR FGFR3 FGFR2
2 bone morphogenesis GO:0060349 9.4 FGFR3 FGFR2
3 sterol metabolic process GO:0016125 9.37 CYP21A2 CYP19A1
4 gonad development GO:0008406 9.32 FSHR CGA
5 positive regulation of phospholipase activity GO:0010518 9.26 FGFR3 FGFR2
6 endochondral bone growth GO:0003416 9.16 FGFR3 FGFR2
7 female gonad development GO:0008585 9.13 FSHR FOXL2 CYP19A1
8 uterus development GO:0060065 8.8 FSHR FOXL2 CYP19A1

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hydroxylase activity GO:0008395 9.26 CYP21A2 CYP19A1
2 steroid binding GO:0005496 9.16 SHBG CYP21A2
3 fibroblast growth factor binding GO:0017134 8.96 FGFR3 FGFR2
4 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR3 FGFR2
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Sources for Luteoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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