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MCID: LYM017
MIFTS: 68

Lyme Disease

Categories: Rare diseases, Infectious diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Lyme Disease

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MalaCards integrated aliases for Lyme Disease:

Name: Lyme Disease 12 76 53 59 55 43 3 44 15 73
Lyme Neuroborreliosis 12 55 44 73
Lyme Borreliosis 12 53 59
Neuroborreliosis 12 73
Borreliosis 53 55
Neurological Lyme Disease 12
Bannworth's Syndrome 12
Borrelia Infections 73
Bannwarth Syndrome 12
Lym 76

Characteristics:

Orphanet epidemiological data:

59
lyme disease
Inheritance: Not applicable; Prevalence: >1/1000 (Europe),1-5/10000 (France); Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare neurological diseases
Rare infectious diseases


Sources

Summaries for Lyme Disease

About this section
MedlinePlus : 43 Lyme disease is a bacterial infection you get from the bite of an infected tick. The first symptom is usually a red rash, which may look like a bull's eye. But not all people with Lyme disease have a rash. As the infection spreads to other parts of the body, you may have A fever A headache Body aches A stiff neck Fatigue Lyme disease can be hard to diagnose because many of its symptoms are like those of the flu and other diseases. And you may not have noticed a tick bite. Your health care provider will look at your symptoms and medical history to figure out whether you have Lyme disease. Lab tests may not always give a clear answer until you have been infected for at least a few weeks. Antibiotics can cure most cases of Lyme disease. The sooner treatment begins, the quicker and more complete the recovery. After treatment, some patients may still have muscle or joint aches and nervous system symptoms. This is called post-treatment Lyme disease syndrome (PTLDS). Long-term antibiotics have not been shown to help with PTLDS. However, there are ways to help with the symptoms of PTLDS, and most patients do get better with time. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Lyme Disease, also known as lyme neuroborreliosis, is related to relapsing fever and cat-scratch disease, and has symptoms including fever, headache and fatigue. An important gene associated with Lyme Disease is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ceftriaxone and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and testes, and related phenotypes are uveitis and photophobia

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Borrelia burgdorferi, which is transmitted by blacklegged tick (Ixodes scapularis) or transmitted by western blacklegged tick (Ixodes pacificus). The infection has symptom fever, has symptom headache, has symptom fatigue, and has symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

Genetics Home Reference : 25 Lyme disease is an infectious disease caused by Borrelia burgdorferi bacteria. The bacteria are transferred to humans by tick bite, specifically by blacklegged ticks (commonly known as deer ticks). The condition is named for the location in which it was first described, the town of Lyme, Connecticut.

NIH Rare Diseases : 53 Lyme disease is the most common tickborne infectious disease in the United States. Early signs and symptoms of the condition include fever, chills, muscle pain, headache, and joint pain. As the condition progresses, affected people may experience heart problems, Bell's palsy, arthritis, abnormal muscle movement, speech problems and cognitive (thinking) abnormalities. Please visit the Center for Disease Control and Prevention's Web site for a more comprehensive list of symptoms. Lyme disease is caused by the bacterium Borrelia burgdorferi, which is transmitted to humans through the bite of infected blacklegged ticks. Certain features of the condition, including whether or not an affected person will develop medication-resistant chronic arthritis, is thought to be influenced by genetic factors (certain human leukocyte antigen genes). Treatment generally includes antibiotics to address the bacterial infection and other medications (i.e. pain medications) to relieve symptoms.

CDC : 3 Get Email Updates

Wikipedia : 76 Lyme disease, also known as Lyme borreliosis, is an infectious disease caused by bacteria of the... more...

Sources

Related Diseases for Lyme Disease

About this section

Diseases related to Lyme Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 387)
# Related Disease Score Top Affiliating Genes
1 relapsing fever 30.6 CFH CRP TNF
2 cat-scratch disease 30.4 CD40LG HSPD1
3 choroiditis 30.4 CFH TNF
4 multifocal choroiditis 30.3 CFH TNF
5 mononeuritis multiplex 30.0 CD40LG CRP
6 japanese spotted fever 29.6 CD40LG CRP
7 myocarditis 29.6 CD40LG IL6 TNF
8 chronic fatigue syndrome 29.5 IL1B IL6 TNF
9 glomerulonephritis 29.5 C3 CD40LG CFH IL1B
10 transverse myelitis 29.3 IL17A IL6 TNF
11 myelitis 29.3 IL17A IL6 TNF
12 panuveitis 28.9 CD40LG IL17A TNF
13 toxoplasmosis 28.8 CD40LG IL1B IL6 TNF
14 stromal keratitis 28.8 IL17A IL6 TNF
15 spondyloarthropathy 28.7 IL17A IL6 TNF
16 arthritis 28.6 IL17A IL1B IL6 TNF
17 q fever 28.6 CD40LG IL1B TLR1 TLR2 TNF
18 pericarditis 28.5 CRP IL1B IL6 TNF
19 otitis media 28.4 CD40LG IL1B IL6 TLR2 TNF
20 neurosyphilis 28.3 IL17A TLR1 TLR2 TLR6
21 scrub typhus 28.2 CD40LG CRP IL1B TLR2 TNF
22 peritonitis 28.1 CRP IL1B IL6 TLR2 TNF
23 multiple sclerosis 27.8 CLDN11 IL17A IL1B IL6 TNF
24 meningitis 27.7 CD40LG CRP IL1B IL6 TLR2 TNF
25 psoriatic arthritis 27.0 CRP IL17A IL1B IL6 TNF
26 systemic lupus erythematosus 26.6 C3 CD40LG CRP IL17A IL6 TNF
27 rheumatoid arthritis 26.0 CD40LG CRP IL17A IL1B IL6 TLR2
28 lyme disease - neurological complications 12.4
29 human granulocytic anaplasmosis 11.2
30 babesiosis 11.2
31 powassan encephalitis 11.1
32 tick infestation 11.1
33 pars planitis 10.8
34 intermediate uveitis 10.8
35 atrophoderma of pierini and pasini 10.8
36 autoimmune inner ear disease 10.8
37 idiopathic hypertrophic pachymeningitis 10.8
38 lymphocytic infiltrate of jessner 10.8
39 pseudopelade of brocq 10.8
40 complement factor h deficiency 10.7 CFH CFHR1
41 fallopian tube disease 10.7 CD40LG HSPD1
42 dense deposit disease 10.6 C3 CFH
43 salpingitis 10.6 CD40LG HSPD1
44 anterior uveitis 10.6 CFH IL6 TLR2
45 prosthetic joint infection 10.6 IL1B TLR2
46 bartonellosis 10.6 CD40LG HSPD1
47 c3 glomerulopathy 10.6 C3 CFHR1
48 retinal drusen 10.6 C3 CFH
49 scorpion envenomation 10.6 IL6 TNF
50 polyclonal hypergammaglobulinemia 10.5 CD40LG IL6

Graphical network of the top 20 diseases related to Lyme Disease:



Diseases related to Lyme Disease
Sources

Symptoms & Phenotypes for Lyme Disease

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Symptoms:

12
  • • fever
  • • headache
  • • fatigue
  • • skin rash called erythema migrans

Human phenotypes related to Lyme Disease:

59 32 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 uveitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000554
2 photophobia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000613
3 meningitis 59 32 frequent (33%) Frequent (79-30%) HP:0001287
4 muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0001324
5 arthritis 59 32 frequent (33%) Frequent (79-30%) HP:0001369
6 joint swelling 59 32 frequent (33%) Frequent (79-30%) HP:0001386
7 atrioventricular block 59 32 occasional (7.5%) Occasional (29-5%) HP:0001678
8 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
9 nausea and vomiting 59 32 occasional (7.5%) Occasional (29-5%) HP:0002017
10 headache 59 32 occasional (7.5%) Occasional (29-5%) HP:0002315
11 memory impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0002354
12 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
13 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
14 myalgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0003326
15 paresthesia 59 32 occasional (7.5%) Occasional (29-5%) HP:0003401
16 dermal atrophy 59 32 occasional (7.5%) Occasional (29-5%) HP:0004334
17 cranial nerve paralysis 59 32 frequent (33%) Frequent (79-30%) HP:0006824
18 arrhythmia 59 32 occasional (7.5%) Occasional (29-5%) HP:0011675
19 fatigue 59 32 occasional (7.5%) Occasional (29-5%) HP:0012378
20 amaurosis fugax 59 32 occasional (7.5%) Occasional (29-5%) HP:0100576
21 insomnia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100785
22 skin nodule 59 32 occasional (7.5%) Occasional (29-5%) HP:0200036
23 behavioral abnormality 59 Occasional (29-5%)
24 peripheral neuropathy 59 Occasional (29-5%)

UMLS symptoms related to Lyme Disease:


fever, pruritus

GenomeRNAi Phenotypes related to Lyme Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 C3 CFHR1 CLDN11 HSPD1 IL17A TLR1

MGI Mouse Phenotypes related to Lyme Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 TLR1 CFH TLR2 TLR6 TNF IL17A
2 cardiovascular system MP:0005385 10.01 TNF IL6 CD40LG CFH TLR2 CRP
3 immune system MP:0005387 10 TLR1 CFH TLR2 TLR6 CRP TNF
4 endocrine/exocrine gland MP:0005379 9.97 TNF YBX3 IL6 CD40LG TLR2 CLDN11
5 nervous system MP:0003631 9.85 YBX3 CFH TLR2 CLDN11 HSPD1 TNF
6 renal/urinary system MP:0005367 9.43 IL6 CD40LG CFH TLR2 IL17A C3
7 reproductive system MP:0005389 9.23 YBX3 CD40LG CLDN11 TLR6 HSPD1 TNF
Sources

Drugs & Therapeutics for Lyme Disease

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Drugs for Lyme Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 73384-59-5 5479530 5361919
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
3
Clarithromycin Approved Phase 4 81103-11-9 84029
4
Hydroxychloroquine Approved Phase 4 118-42-3 3652
5
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5361202 5479529
6
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
7
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
8
Azithromycin Approved Phase 4,Phase 1,Phase 2 83905-01-5 55185 447043
9
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
10 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable
13 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Antirheumatic Agents Phase 4
17 Antitubercular Agents Phase 4,Phase 2,Not Applicable
18 Cytochrome P-450 CYP3A Inhibitors Phase 4,Not Applicable
19 Cytochrome P-450 Enzyme Inhibitors Phase 4,Not Applicable
20 cefuroxime axetil Phase 4,Not Applicable
21 penicillins Phase 4
22 Erythromycin Estolate Phase 4
23 Erythromycin Ethylsuccinate Phase 4
24 Erythromycin stearate Phase 4
25
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
26
Permethrin Approved, Investigational Phase 3 52645-53-1 40326
27 PENTA Phase 3
28 Vaccines Phase 1, Phase 2,Not Applicable
29
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
30
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
31
Aluminum sulfate Approved Phase 1 10043-01-3
32 Gastrointestinal Agents Phase 1
33 Adjuvants, Immunologic Phase 1
34 Antacids Phase 1
35 Anti-Ulcer Agents Phase 1
36
Didanosine Approved Not Applicable 69655-05-6 50599
37
Lamivudine Approved, Investigational Not Applicable 134678-17-4 60825
38
Lopinavir Approved Not Applicable 192725-17-0 92727
39
Ritonavir Approved, Investigational Not Applicable 155213-67-5 392622
40
Stavudine Approved, Investigational Not Applicable 3056-17-5 18283
41
Zidovudine Approved Not Applicable 30516-87-1 35370
42
Ethanol Approved 64-17-5 702
43
Hydroxocobalamin Approved 13422-51-0 11953898 44475014
44
Granisetron Approved, Investigational Not Applicable 109889-09-0 3510
45
Acyclovir Approved 59277-89-3 2022
46
Dopamine Approved 51-61-6, 62-31-7 681
47
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
48
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical 13422-55-4
49 Antibodies ,Not Applicable
50 Immunoglobulins ,Not Applicable

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Study of Lyme Neuroborreliosis Unknown status NCT01635530 Phase 4 Doxycycline;Ceftriaxone
2 Persistent Lyme Empiric Antibiotic Study Europe Completed NCT01207739 Phase 4 Doxycycline;Clarithromycin and hydroxychloroquine;Placebo
3 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
4 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
5 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
6 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
7 Study and Treatment of Post Lyme Disease (STOP-LD) Completed NCT00000937 Phase 3 Antibiotics
8 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seropositive Chronic Lyme Disease Completed NCT00001101 Phase 3 ceftriaxone;doxycycline
9 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease Completed NCT00000938 Phase 3 ceftriaxone;doxycycline
10 Lyme Disease Prevention Program Completed NCT00000432 Phase 3
11 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment
12 Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis Completed NCT00138801 Phase 3 Ceftriaxone;Doxycycline
13 Six Versus Two Weeks Treatment With Doxycycline in Lyme Neuroborreliosis Enrolling by invitation NCT02553473 Phase 3 Doxycycline;Placebo
14 Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes Terminated NCT00958139 Phase 3
15 A Placebo-controlled Efficacy Study of IV Ceftriaxone for Refractory Psychosis Unknown status NCT00591318 Phase 1, Phase 2 ceftriaxone;Normal Saline
16 Brain Imaging and Retreatment Study of Persistent Lyme Disease Completed NCT00037479 Phase 2 ceftriaxone
17 Safety, Skin and Plasma Concentration of Azithromycin Dermal Formulation Completed NCT01243008 Phase 1, Phase 2 Application of SHB001
18 Antibiotic Treatment Trial for the PANDAS/PANS Phenotype Completed NCT01617083 Phase 2 Azithromycin;Placebo
19 Phase 1/2 Lyme Vaccine Study Completed NCT01504347 Phase 1, Phase 2
20 Xenodiagnosis After Antibiotic Treatment for Lyme Disease Recruiting NCT02446626 Phase 1, Phase 2
21 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
22 Study Assessing the Safety, Immunogenicity and Dose Response of VLA15, A New Vaccine Candidate Against Lyme Borreliosis Active, not recruiting NCT03010228 Phase 1
23 Meditation and Stretching for Post Treatment Lyme Disease Syndrome Unknown status NCT02344537 Not Applicable
24 A School-Based Intervention to Reduce Lyme Disease Unknown status NCT00594997 Not Applicable
25 Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis Unknown status NCT00942006 Not Applicable doxycycline;ceftriaxone
26 Searching for Persistence of Infection in Lyme Disease Completed NCT01143558 Early Phase 1
27 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754 Not Applicable
28 Sofia 2 Lyme FIA Whole Blood Clinical Study Completed NCT03238274
29 CD8 Reactivity to Microorganisms in Blood and Breast Milk Completed NCT03084614
30 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
31 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708 Doxycycline
32 Study of Anti-HIV Therapy Intensification Completed NCT00034086 Not Applicable Lopinavir/Ritonavir;Lamivudine/Zidovudine;Tenofovir disoproxil fumarate;Lamivudine;Stavudine;Zidovudine;Didanosine
33 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715 Not Applicable doxycycline;doxycycline;placebo
34 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
35 Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel Recruiting NCT03581279 Not Applicable
36 Evaluation, Treatment, and Follow-up of Patients With Lyme Disease Recruiting NCT00028080
37 A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations Recruiting NCT00001539
38 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082
39 Lyme Test Indication Combinations (LyTIC) Study Recruiting NCT03201042
40 Analysis of Lyme Disease Lesions Recruiting NCT00132327
41 Characteristics of Lyme Arthritis Recruiting NCT03510507
42 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789 Not Applicable
43 Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health Recruiting NCT02669212
44 Screening for the Transthyretin-Related Familial Amyloidotic Small Fiber Polyneuropathy Recruiting NCT01705626
45 Duration of Doxycycline Treatment in MEM Patients Recruiting NCT03337932 Not Applicable Doxycycline 100 milligram Oral Tablet bid, 7 days;Doxycycline 100 milligram Oral Tablet bid, 14 days;Controls without a history of lyme disease.
46 Tick-borne Encephalitis and Positive Borrelial Antibodies Recruiting NCT02463942 Not Applicable Doxycycline;Symptomatic therapy
47 Duration of Doxycycline Treatment in EM Patients Recruiting NCT03153267 Not Applicable Doxycycline 100 MG Oral Tablet bid, 7 days;Doxycycline 100 MG Oral Tablet bid, 14 days;Controls without a history of lyme disease.
48 Laboratory Characteristics in Chronic Atrophic Acrodermatitis Recruiting NCT02147262 Not Applicable doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
49 Central Nervous System Infections in Denmark Recruiting NCT03418441
50 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Lyme Disease

Cochrane evidence based reviews: lyme disease

Sources

Genetic Tests for Lyme Disease

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Sources

Anatomical Context for Lyme Disease

About this section

MalaCards organs/tissues related to Lyme Disease:

41
Heart, Skin, Testes, Eye, Brain, Whole Blood, Lung
Sources

Publications for Lyme Disease

About this section

Articles related to Lyme Disease:

(show top 50) (show all 861)
# Title Authors Year
1
Revisiting the Lyme Disease Serodiagnostic Algorithm: The Momentum Gathers. ( 29898997 )
2018
2
Insights from the Geographic Spread of the Lyme Disease Epidemic. ( 29920580 )
2018
3
Humanizing the digital revolution, the secret life of yeast and Lyme disease through a climate lens: Books in brief. ( 29446403 )
2018
4
Amblyomma americanum (Acari: Ixodidae) Ticks Are Not Vectors of the Lyme Disease Agent, Borrelia burgdorferi (Spirocheatales: Spirochaetaceae): A Review of the Evidence. ( 29394366 )
2018
5
Ticks transmitting Lyme disease are found in a third of Britain, mainly the south. ( 29440061 )
2018
6
Sleep Quality in Well-defined Lyme Disease: A Clinical Cohort Study in Maryland. ( 29452400 )
2018
7
Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic. ( 29359181 )
2018
8
Lyme disease surveillance in the United States: Looking for ways to cut the Gordian knot. ( 29431297 )
2018
9
Cognitive Decline in Post-treatment Lyme Disease Syndrome. ( 29945190 )
2018
10
Obstacles to diagnosis and treatment of Lyme disease in the USA: a qualitative study. ( 29895655 )
2018
11
Identification of surface epitopes associated with protection against highly immune-evasive VlsE-expressing Lyme disease spirochetes. ( 29866906 )
2018
12
Catching up with Lyme Disease Antigenic Variation Computationally. ( 29903419 )
2018
13
Lyme disease presenting with multiple cranial neuropathies on MRI. ( 29942765 )
2018
14
Obsessive-compulsive symptoms in adults with Lyme disease. ( 29408088 )
2018
15
Of ignorance and blindness: The Lyme disease paradigm. ( 29805049 )
2018
16
Exploring an alternative approach to Lyme disease surveillance in Maryland. ( 29411541 )
2018
17
Relative Risk for Ehrlichiosis and Lyme Disease Where Vectors for Both Are Sympatric, Southeastern United States. ( 29350157 )
2018
18
Exacerbation of chronic pain after dental extractions in a patient with post-treatment Lyme disease syndrome. ( 29416466 )
2018
19
Multiflora rose invasion amplifies prevalence of Lyme disease pathogen, but not necessarily Lyme disease risk. ( 29361971 )
2018
20
Clinical manifestations of reported Lyme disease cases in Ontario, Canada: 2005-2014. ( 29856831 )
2018
21
Serologic Evidence of Tick-Borne Encephalitis Virus Infection in a Patient with Suspected Lyme Disease in Japan. ( 29848409 )
2018
22
The Financial Implications of a Well-Hidden and Ignored Chronic Lyme Disease Pandemic. ( 29438352 )
2018
23
Correction to: Development of a sensitive PCR-dot blot assay to supplement serological tests for diagnosing Lyme disease. ( 29404837 )
2018
24
An Unusual Cluster of Neuroinvasive Lyme Disease Cases Presenting With Bannwarth Syndrome in the Midwest United States. ( 29383323 )
2018
25
Lyme Disease Testing in a High-Incidence State: Clinician Knowledge and Patterns. ( 29425271 )
2018
26
Incidence of Lyme Disease Diagnosis in a Maryland Medicaid Population, 2004-2011. ( 29955850 )
2018
27
Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR. ( 29443061 )
2018
28
Recognizing Lyme Disease. ( 29957621 )
2018
29
Tick borne illness-Lyme disease. ( 29402399 )
2018
30
<i>Ixodes</i> Immune Responses Against Lyme Disease Pathogens. ( 29896452 )
2018
31
Motivations and Experiences of Canadians Seeking Treatment for Lyme Disease Outside of the Conventional Canadian Health-Care System. ( 29978028 )
2018
32
Improvement of common variable immunodeficiency using embryonic stem cell therapy in a patient with lyme disease: a clinical case report. ( 29881587 )
2018
33
A Community Study of <i>Borrelia burgdorferi</i> Antibodies among Individuals with Prior Lyme Disease in Endemic Areas. ( 29921784 )
2018
34
Borrelia burgdorferi in small mammal reservoirs in Kentucky, a traditionally non-endemic state for Lyme disease. ( 29417273 )
2018
35
The oligopeptide ABC transporter OppA4 negatively regulates the virulence factor OspC production of the Lyme disease pathogen. ( 29921537 )
2018
36
Lack of Evidence for Transovarial Transmission of the Lyme Disease Spirochete Borrelia mayonii by Infected Female Ixodes scapularis (Acari: Ixodidae) Ticks. ( 29365151 )
2018
37
The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease. ( 29957333 )
2018
38
Detection of Lyme disease causing Borrelia burgdorferi s.l. in questing Ixodes ricinus ticks on Jersey. ( 28751172 )
2017
39
Effects of intravenous ketamine in a patient with post-treatment Lyme disease syndrome. ( 28860873 )
2017
40
Succinyl-I^-cyclodextrin modified gold biochip improved seroimmunological detection sensitivity for Lyme disease. ( 28010742 )
2017
41
Transmission of the Lyme Disease Spirochete Borrelia mayonii in Relation to Duration of Attachment by Nymphal Ixodes scapularis (Acari: Ixodidae). ( 28874016 )
2017
42
Isolation of the Lyme Disease Spirochete Borrelia mayonii From Naturally Infected Rodents in Minnesota. ( 28444198 )
2017
43
Borrelia burgdorferi-specific IgA in Lyme Disease. ( 28457619 )
2017
44
Geographic Expansion of Lyme Disease in Michigan, 2000-2014. ( 28480261 )
2017
45
There Is a Method to the Madness: Strategies to Study Host Complement Evasion by Lyme Disease and Relapsing Fever Spirochetes. ( 28303129 )
2017
46
Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control. ( 28438910 )
2017
47
Lyme Disease and YouTubeTM: A Cross-Sectional Study of Video Contents. ( 28904853 )
2017
48
Comparison of Vector Efficiency of Ixodes scapularis (Acari: Ixodidae) From the Northeast and Upper Midwest of the United States for the Lyme Disease Spirochete Borrelia mayonii. ( 28082653 )
2017
49
Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development. ( 28479174 )
2017
50
TH17 Cytokine Responses in Lyme Disease Correlate with Borreliaburgdorferi Antibodies During Early Infection in Patients with Erythema Migrans and with Autoantibodies Late in the Illness in Patients with Antibiotic-Refractory Lyme Arthritis. ( 28077518 )
2017
Sources

Variations for Lyme Disease

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Sources

Expression for Lyme Disease

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Search GEO for disease gene expression data for Lyme Disease.
Sources

Pathways for Lyme Disease

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Pathways related to Lyme Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.98 C3 CD40LG CFH CRP IL17A IL1B
2
Akt Signaling 64
Show member pathways
 13.37 CD40LG IL17A IL1B IL6 TLR1 TLR2
3
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.95 C3 IL1B IL6 TLR1 TLR2 TLR6
4
Allograft rejection 1 37
Show member pathways
 12.79 C3 CD40LG HSPD1 IL17A IL1B IL6
5
IL-2 Pathway 64
Show member pathways
 12.77 IL1B TLR1 TLR2 TLR6 TNF
6
Influenza A 37
Show member pathways
 12.77 C3 IL1B IL6 TLR2 TNF
7
NF-KappaB Family Pathway 64
Show member pathways
 12.62 CD40LG IL1B IL6 TLR1 TLR2 TLR6
8
Regulation of IFNA signaling 66
Show member pathways
 12.59 IL17A IL1B IL6 TNF
9
Immune response IL-23 signaling pathway 22
Show member pathways
 12.54 IL17A IL1B IL6 TNF
10
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.53 C3 IL6 TLR2 TNF
11
Th17 cell differentiation 37
Show member pathways
 12.43 IL17A IL1B IL6 TLR2 TNF
12
T cell receptor signaling pathway 37
Show member pathways
 12.41 CD40LG IL17A IL1B IL6 TNF
13
TRAF Pathway 64
Show member pathways
 12.41 CD40LG IL1B TLR1 TLR2 TLR6 TNF
14
NF-kappaB Signaling 4
12.38 CD40LG IL17A IL1B TLR1 TLR2 TLR6
15
Folate Metabolism 1
Show member pathways
 12.31 CRP IL1B IL6 TNF
16
IL-17 Family Signaling Pathways 65
Show member pathways
 12.31 IL17A IL1B IL6 TLR2 TNF
17
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.22 IL6 TLR1 TLR2 TLR6 TNF
18
IL-1 Family Signaling Pathways 65
Show member pathways
 12.21 IL1B IL6 TLR2 TNF
19
Toxoplasmosis 37
Show member pathways
 12.21 C3 CD40LG IL1B TLR2 TNF
20
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.17 HSPD1 IL1B IL6 TNF
21
Colorectal Cancer Metastasis 64
12.11 IL6 TLR1 TLR2 TLR6 TNF
22
Bacterial infections in CF airways 22
Show member pathways
 12.06 IL1B IL6 TLR1 TLR2 TLR6 TNF
23
MAPK Pathway 72
Show member pathways
 12.03 IL1B TLR1 TLR2 TLR6
24
Interleukin-4 and 13 signaling 66
11.99 IL17A IL1B IL6 TNF
25
Spinal Cord Injury 1
11.97 IL1B IL6 TNF
26
Th1 Differentiation Pathway 65
Show member pathways
 11.97 IL17A IL1B IL6 TLR1 TLR2 TLR6
27
TNF signaling pathway 37
11.91 IL1B IL6 TNF
28
Amoebiasis 37
11.88 IL1B IL6 TLR2 TNF
29
AGE-RAGE signaling pathway in diabetic complications 37
11.87 IL1B IL6 TNF
30
Hematopoietic cell lineage 37
11.86 IL1B IL6 TNF
31
NF-kappa B signaling pathway 37
11.85 CD40LG IL1B TNF
32
Phagocytosis of Microbes 64
11.81 C3 TLR1 TLR2 TLR6
33
Rheumatoid arthritis 37
11.79 IL17A IL1B IL6 TLR2 TNF
34
Innate Lymphoid Cell Differentiation Pathways 65
11.77 IL17A IL1B TNF
35
Pertussis 37
11.75 C3 IL1B IL6 TNF
36
Dendritic Cells Developmental Lineage Pathway 65
11.73 IL1B IL6 TNF
37
Lung fibrosis 1
11.66 IL1B IL6 TNF
38
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.62 CD40LG IL1B IL6 TNF
40
Interleukin-10 signaling 66
11.54 IL1B IL6 TNF
41
MSP-RON Signaling 64
11.53 IL1B TLR2 TNF
42
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.49 IL1B IL6 TNF
43
Tuberculosis 37
11.48 C3 HSPD1 IL1B IL6 TLR1 TLR2
44
African trypanosomiasis 37
11.37 IL1B IL6 TNF
45
IL-10 Pathway 64
11.37 IL1B IL6 TNF
46
Malaria 37
11.34 CD40LG IL1B IL6 TLR2 TNF
47
Antifolate resistance 37
11.31 IL1B IL6 TNF
48
Cytokines and Inflammatory Response 1
11.29 IL1B IL6 TNF
49
Development and heterogeneity of the ILC family 1
11.28 IL17A IL1B IL6 TNF
50
IL1 and megakaryocytes in obesity 1
11.2 IL1B TLR1 TLR2
Sources

GO Terms for Lyme Disease

About this section

Cellular components related to Lyme Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 C3 CD40LG CFH CFHR1 CRP IL17A
2 membrane raft GO:0045121 9.56 TLR1 TLR2 TLR6 TNF
3 phagocytic vesicle membrane GO:0030670 9.5 TLR1 TLR2 TLR6
4 extracellular space GO:0005615 9.32 C3 CD40LG CFH CFHR1 CRP HSPD1
5 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.96 TLR1 TLR2

Biological processes related to Lyme Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.99 IL17A IL1B IL6 TNF
2 positive regulation of gene expression GO:0010628 9.95 CRP IL1B IL6 TLR2 TLR6 TNF
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.88 IL1B IL6 TNF
4 regulation of complement activation GO:0030449 9.87 C3 CFH CFHR1
5 complement activation GO:0006956 9.86 C3 CFH CFHR1
6 positive regulation of T cell proliferation GO:0042102 9.85 CD40LG IL1B IL6
7 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 IL1B TLR2 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.83 CRP IL6 TLR2 TNF
9 toll-like receptor signaling pathway GO:0002224 9.82 TLR1 TLR2 TLR6
10 positive regulation of interferon-gamma production GO:0032729 9.81 HSPD1 IL1B TNF
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B TLR6 TNF
12 positive regulation of phagocytosis GO:0050766 9.78 C3 IL1B TNF
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL1B TLR2 TNF
14 positive regulation of interleukin-8 production GO:0032757 9.74 IL1B TLR2 TNF
15 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 CD40LG IL1B IL6 TLR2 TLR6 TNF
16 positive regulation of interleukin-12 production GO:0032735 9.72 CD40LG HSPD1 TLR2
17 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
19 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 IL17A TLR6
20 positive regulation of interleukin-10 production GO:0032733 9.71 CD40LG HSPD1 TLR2
21 positive regulation of macrophage activation GO:0043032 9.7 HSPD1 TLR6
22 microglial cell activation GO:0001774 9.7 TLR2 TLR6
23 positive regulation of interleukin-8 secretion GO:2000484 9.69 TLR1 TLR2
24 complement activation, alternative pathway GO:0006957 9.69 C3 CFH
25 positive regulation of chemokine production GO:0032722 9.69 IL6 TLR2 TNF
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
27 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
28 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
29 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
30 cell activation GO:0001775 9.67 TLR1 TLR2 TLR6
31 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.67 HSPD1 TLR1 TLR2 TLR6
32 regulation of immunoglobulin secretion GO:0051023 9.66 CD40LG TNF
33 cellular response to diacyl bacterial lipopeptide GO:0071726 9.65 TLR2 TLR6
34 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.65 TLR2 TLR6
35 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
36 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.63 TLR1 TLR2
37 regulation of cytokine secretion GO:0050707 9.63 TLR1 TLR2 TLR6
38 cellular response to triacyl bacterial lipopeptide GO:0071727 9.62 TLR1 TLR2
39 nitric oxide metabolic process GO:0046209 9.62 TLR2 TLR6
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
41 negative regulation of lipid storage GO:0010888 9.61 CRP IL6 TNF
42 immune response GO:0006955 9.61 C3 CD40LG IL17A IL1B IL6 TLR1
43 detection of triacyl bacterial lipopeptide GO:0042495 9.59 TLR1 TLR2
44 response to bacterial lipoprotein GO:0032493 9.58 TLR2 TLR6
45 detection of diacyl bacterial lipopeptide GO:0042496 9.58 TLR2 TLR6
46 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.58 IL1B TLR1 TLR6
47 positive regulation of interleukin-6 production GO:0032755 9.55 HSPD1 IL1B IL6 TLR2 TNF
48 cellular response to bacterial lipopeptide GO:0071221 9.5 TLR1 TLR2 TLR6
49 inflammatory response GO:0006954 9.32 C3 CD40LG CRP IL17A IL1B IL6
50 regulation of signaling receptor activity GO:0010469 10.07 CD40LG IL17A IL1B IL6 TNF

Molecular functions related to Lyme Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 CD40LG IL17A IL1B IL6 TNF
2 Toll-like receptor 2 binding GO:0035663 9.16 TLR1 TLR6
3 lipopeptide binding GO:0071723 8.8 TLR1 TLR2 TLR6
4 protein binding GO:0005515 10.13 C3 CD40LG CFH CFHR1 CLDN11 CRP
Sources

Sources for Lyme Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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