MCID: LYM020
MIFTS: 40

Lymph Node Cancer

Categories: Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymph Node Cancer

MalaCards integrated aliases for Lymph Node Cancer:

Name: Lymph Node Cancer 12 15 74
Lymph Node Neoplasm 12 54
Neoplasm of Lymph Node 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10619
NCIt 51 C35497

Summaries for Lymph Node Cancer

Disease Ontology : 12 A lymphatic system cancer that is located in the lymph node.

MalaCards based summary : Lymph Node Cancer, also known as lymph node neoplasm, is related to lymphoma, hodgkin, classic and lymph node adenoid cystic carcinoma. An important gene associated with Lymph Node Cancer is SCG2 (Secretogranin II), and among its related pathways/superpathways are TNFR1 Pathway and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Nilutamide and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, prostate and lung, and related phenotypes are Increased cell death HMECs cells and cardiovascular system

Wikipedia : 77 Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). The... more...

Related Diseases for Lymph Node Cancer

Graphical network of the top 20 diseases related to Lymph Node Cancer:



Diseases related to Lymph Node Cancer

Symptoms & Phenotypes for Lymph Node Cancer

GenomeRNAi Phenotypes related to Lymph Node Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 8.92 IGF1R KCNA3 PLAUR TP53

MGI Mouse Phenotypes related to Lymph Node Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 FN1 IGF1R PLAUR SCG2 TP53
2 limbs/digits/tail MP:0005371 9.55 FN1 FOS IGF1R IGFBP3 TP53
3 liver/biliary system MP:0005370 9.35 FN1 IGF1R IGFBP3 PLAUR TP53
4 muscle MP:0005369 9.1 FN1 IGF1R IGFBP3 KCNA3 PLAUR TP53

Drugs & Therapeutics for Lymph Node Cancer

Drugs for Lymph Node Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nilutamide Approved, Investigational Phase 3 63612-50-0 4493
2
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
3 glucocorticoids Phase 3,Not Applicable
4 Anti-Inflammatory Agents Phase 3,Not Applicable
5 Hormone Antagonists Phase 3,Not Applicable
6 Cytochrome P-450 Enzyme Inhibitors Phase 3
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
8
Abiraterone acetate Phase 3 154229-18-2 57336518
9 Steroid Synthesis Inhibitors Phase 3
10 Antineoplastic Agents, Hormonal Phase 3,Not Applicable
11 Androgens Phase 3
12 Hormones Phase 3,Not Applicable
13 Androgen Antagonists Phase 3
14
Ipilimumab Approved Phase 2 477202-00-9
15
nivolumab Approved Phase 2,Phase 1 946414-94-4
16
Vorinostat Approved, Investigational Phase 1, Phase 2 149647-78-9 5311
17
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
18 Immunoglobulins Phase 2
19 Antibodies Phase 2
20 Antineoplastic Agents, Immunological Phase 2,Phase 1
21 Histone Deacetylase Inhibitors Phase 1, Phase 2
22
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
23 Alkylating Agents Phase 1
24 Antineoplastic Agents, Alkylating Phase 1
25
Hydrocortisone Approved, Vet_approved Not Applicable 50-23-7 5754
26
Hydrocortisone acetate Approved, Vet_approved Not Applicable 50-03-3
27
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 27284 23925
28
Oxaliplatin Approved, Investigational 61825-94-3 43805 6857599 5310940 9887054
29
Capecitabine Approved, Investigational 154361-50-9 60953
30
Pancrelipase Approved, Investigational 53608-75-6
31
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
32
leucovorin Approved Not Applicable 58-05-9 143 6006
33
Zidovudine Approved Not Applicable 30516-87-1 35370
34
Methotrexate Approved Not Applicable 1959-05-2, 59-05-2 126941
35
Levoleucovorin Approved, Investigational Not Applicable 68538-85-2
36
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
37
Choline Approved, Nutraceutical Not Applicable 62-49-7 305
38
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
39
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
40 Antimetabolites Not Applicable
41 Hydrocortisone hemisuccinate Not Applicable
42 Gastrointestinal Agents Not Applicable
43 Lipid Regulating Agents Not Applicable
44 Nootropic Agents Not Applicable
45 Hypolipidemic Agents Not Applicable
46 Hydrocortisone 17-butyrate 21-propionate Not Applicable
47 Parenteral Nutrition Solutions Not Applicable
48 Hematinics Not Applicable
49 Ferrosoferric Oxide Not Applicable
50 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Discovery Stage Clinical Study About Oncology Drugs and Single Nucleotide Polymorphisms Active, not recruiting NCT02403505 Phase 3 ABIRATERONE - Group 1;ABIRATERONE - Group 2
2 A Phase 2 Study With MIP-1404 in Men With High-Risk PC Scheduled for RP and EPLND Compared to Histopathology Completed NCT01667536 Phase 2 Drug: 99mTc-MIP-1404
3 CMP-001 in Combo With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease Recruiting NCT03618641 Phase 2 CMP-001
4 Pembro and Vorinostat for Patients With Stage IV Non-small Cell Lung Cancer (NSCLC) Recruiting NCT02638090 Phase 1, Phase 2 Vorinostat;Pembrolizumab
5 PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT01500733 Phase 2 PCI 32765
6 Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma Recruiting NCT03426891 Phase 1 Pembrolizumab;Vorinostat;Temozolomide
7 Nivolumab With Epstein Barr Virus Specific T Cells (EBVSTS), Relapsed/Refractory EBV Positive Lymphoma (PREVALE) Recruiting NCT02973113 Phase 1
8 Most Closely HLA-Matched CTLs for Relapsed Epstein Barr Virus(EBV)-Associated Diseases Active, not recruiting NCT01447056 Phase 1
9 [18F] Fluorocholine FCH Positron Emission Tomography (PET)/Computed Tomography (CT) for Detection of Prostate Cancer Lymph Nodes Metastases Unknown status NCT00670527 Not Applicable
10 Pre-Operative Nodal Staging of Thyroid Cancer Using USPIO MRI: Preliminary Study Completed NCT01927887 Not Applicable Ferumoxytol
11 Lymph Node Metastasis in Extended Lymphadenectomy for Gastric Cancer From a CLASSIC Trial Completed NCT02298010 Capecitabine, oxaliplatin
12 Lymph Node Involvement Using Extended Pelvic Lymphadenectomy in Clinically Localized Prostate Cancer Completed NCT02156414
13 Videoscopic Ilioinguinal Lymphadenectomy for Melanoma Completed NCT02508909 Not Applicable
14 Clinical Impact of EUS Elastography Mean Strain Histograms (SH) and Contrast Peak-enhancement in Focal Pancreatic Masses and Lymph Nodes Completed NCT02459041
15 Tissue Characterisation by Endoscopic GI-elastography Completed NCT01360411
16 High Dose SBRT for Abdominal-Pelvic Lymph Nodal Lesions in Oligometastatic Patients Recruiting NCT02570399 Not Applicable
17 Clinical, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Hematologic Cancer Recruiting NCT00039676
18 Family Study of Lymphoproliferative Disorders Recruiting NCT00626496
19 Strategy of Surgical Resection With Adjuvant Therapy for IIIA NSCLC and N2 Disease Only in Subaortic or Paraaortic Level Recruiting NCT02555592
20 Clinical and Technical Feasibility of a Ultrasuperparamagnetic Nanoparticle Iron Oxide (USPIO)-Enhanced Magnetic Resonance Lymph Node Imaging Active, not recruiting NCT01815333 Not Applicable Feraheme
21 Negative Pressure Wound Therapy in Groin Dissection Not yet recruiting NCT02408835 Not Applicable
22 The Use of Chemotherapy Plus Radiotherapy Plus Azidothymidine in Patients With AIDS-Related Lymph Node Cancer Terminated NCT00000723 Not Applicable Methotrexate;Leucovorin calcium;Zidovudine;Dexamethasone
23 Evaluation Of Lymph Nodes After Neoadjuvant Chemotherapy Withdrawn NCT02752009 Not Applicable

Search NIH Clinical Center for Lymph Node Cancer

Genetic Tests for Lymph Node Cancer

Anatomical Context for Lymph Node Cancer

MalaCards organs/tissues related to Lymph Node Cancer:

42
Lymph Node, Prostate, Lung, T Cells, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Lymph Node Cancer:

20
The Lymph Node

Publications for Lymph Node Cancer

Articles related to Lymph Node Cancer:

# Title Authors Year
1
Lymph node cancer of the mediastinum with a putative necrotic primary lesion in the lung: a case report. ( 29606126 )
2018
2
Lymph node cancer of the mediastinal or hilar region with an unknown primary site. ( 7898117 )
1995
3
S-100+ lymph node neoplasm. Report of a case with histological AL and immunological features intermediate between T cell lymphoma and malignant histiocytosis. ( 6437069 )
1984
4
CT of cervical lymph node cancer. ( 6781263 )
1981

Variations for Lymph Node Cancer

Expression for Lymph Node Cancer

Search GEO for disease gene expression data for Lymph Node Cancer.

Pathways for Lymph Node Cancer

Pathways related to Lymph Node Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 FN1 FOS IGF1R TP53
2
Show member pathways
12.53 FOS IGF1R IGFBP3 PLAUR
3 12.43 FN1 FOS IGF1R TP53
4 12.08 FOS PLAUR TP53
5 11.88 IGF1R IGFBP3 TP53
6
Show member pathways
11.84 FOS IGF1R IGFBP3 TP53
7 11.67 FN1 FOS TP53
8 11.56 FN1 IGF1R PLAUR TP53
9 11.55 FN1 FOS TP53
10 11.27 FOS TP53
11 11.23 FN1 PLAUR
12 11.22 FN1 IGF1R PLAUR
13 11.21 FOS PLAUR
14 11.19 FN1 IGF1R
15 11.14 FN1 FOS
16 11.05 IGFBP3 TP53
17 10.95 FN1 IGF1R IGFBP3 TP53

GO Terms for Lymph Node Cancer

Cellular components related to Lymph Node Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.92 FN1 IGFBP3 PLAUR SCG2

Biological processes related to Lymph Node Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.5 FN1 FOS TP53
2 cellular protein metabolic process GO:0044267 9.33 FN1 IGFBP3 SCG2
3 protein tetramerization GO:0051262 9.26 IGF1R TP53
4 positive regulation of release of cytochrome c from mitochondria GO:0090200 8.96 PLAUR TP53
5 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.62 FOS TP53

Molecular functions related to Lymph Node Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.16 FN1 TP53
2 insulin-like growth factor binding GO:0005520 8.96 IGF1R IGFBP3
3 insulin-like growth factor I binding GO:0031994 8.62 IGF1R IGFBP3

Sources for Lymph Node Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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