MCID: LYM020
MIFTS: 35

Lymph Node Cancer

Categories: Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymph Node Cancer

MalaCards integrated aliases for Lymph Node Cancer:

Name: Lymph Node Cancer 12 15 72
Lymph Node Neoplasm 12 53
Neoplasm of Lymph Node 72

Classifications:



External Ids:

Disease Ontology 12 DOID:10619
NCIt 50 C35497
UMLS 72 C0596869 C0948627

Summaries for Lymph Node Cancer

Disease Ontology : 12 A lymphatic system cancer that is located in the lymph node.

MalaCards based summary : Lymph Node Cancer, also known as lymph node neoplasm, is related to lymphoma, hodgkin, classic and lymph node adenoid cystic carcinoma. An important gene associated with Lymph Node Cancer is SCG2 (Secretogranin II), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Endometrial cancer. The drugs nivolumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include lymph node, prostate and t cells, and related phenotypes are Increased cell death HMECs cells and muscle

Wikipedia : 75 Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). The... more...

Related Diseases for Lymph Node Cancer

Graphical network of the top 20 diseases related to Lymph Node Cancer:



Diseases related to Lymph Node Cancer

Symptoms & Phenotypes for Lymph Node Cancer

GenomeRNAi Phenotypes related to Lymph Node Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.02 CSF2 IGF1R KCNA3 PLAUR TP53

MGI Mouse Phenotypes related to Lymph Node Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.35 IGF1R IGFBP3 KCNA3 PLAUR TP53
2 respiratory system MP:0005388 8.92 CSF2 IGF1R PLAUR TP53

Drugs & Therapeutics for Lymph Node Cancer

Drugs for Lymph Node Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 1 946414-94-4
2 Antineoplastic Agents, Immunological Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Assessment of the Diagnostic Accuracy of 99mTc-MIP-1404 Imaging in Men With High-Risk Prostate Cancer Scheduled for Radical Prostatectomy (RP) and Extended Pelvic Lymph Node Dissection (EPLND) Compared to Histopathology Completed NCT01667536 Phase 2 Drug: 99mTc-MIP-1404
2 Phase I Study Combining Nivolumab With Epstein Barr Virus Specific T Cells (EBVSTS) in Relapsed/Refractory EBV Positive Lymphoma Patients (PREVALE) Recruiting NCT02973113 Phase 1
3 Most Closely HLA-Matched Allogeneic LMP1/2-Specific Cytotoxic T Lymphocytes for Treatment of Patients With Relapsed EBV-Associated Diseases Active, not recruiting NCT01447056 Phase 1
4 Lymph Node Involvement Using Extended Pelvic Lymphadenectomy in Clinically Localized Prostate Cancer in Bogota Colombia. Completed NCT02156414
5 Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Blood and Lymph Node Malignancy Recruiting NCT00039676
6 Feasibility Study of High Dose Stereotactic Body Radiation Therapy (SBRT) for Lymph Nodal Lesions in Oligometastatic Patients for Genito-urinary, Gastro-intestinal and Gynaecological Cancer Active, not recruiting NCT02570399

Search NIH Clinical Center for Lymph Node Cancer

Genetic Tests for Lymph Node Cancer

Anatomical Context for Lymph Node Cancer

MalaCards organs/tissues related to Lymph Node Cancer:

41
Lymph Node, Prostate, T Cells, Lung, Colon, Liver, Cervix

The Foundational Model of Anatomy Ontology organs/tissues related to Lymph Node Cancer:

19
Lymph Node

Publications for Lymph Node Cancer

Articles related to Lymph Node Cancer:

(show all 31)
# Title Authors PMID Year
1
Magnetic resonance imaging and photothermal conversion properties of Gd-C nanocomposites for interstitial lymphography. 38
31099983 2019
2
Raman spectroscopy discriminates malignant follicular lymphoma from benign follicular hyperplasia and from tumour metastasis. 38
30609603 2019
3
Lymph node cancer of the mediastinum with a putative necrotic primary lesion in the lung: a case report. 38
29606126 2018
4
[Long-Term Survival of a Patient with Metastatic Liver and Para-Aortic Lymph Node Cancer from Colon Cancer Treated with Regorafenib]. 38
29394758 2017
5
[The Diagnostic Value of Endobronchial Ultrasound-guided Needle Aspiration Biopsy for Lung or Mediastinal Lymph Node Cancer and Tuberculosis]. 38
28616904 2017
6
A comparison of novel organoiridium(III) complexes and their ligands as a potential treatment for prostate cancer. 38
26802546 2016
7
Formation of Tethers from Spreading Cellular Aggregates. 38
26509898 2015
8
Is Stereotactic Body Radiotherapy (SBRT) in lymph node oligometastatic patients feasible and effective? 38
26696788 2015
9
Physical diseases as predictors of suicide in older adults: a nationwide, register-based cohort study. 38
25835959 2015
10
The overview of cancer patients attending in a specialized hospital: A cross sectional study. 38
29624288 2015
11
Voltage-Gated Potassium Channels Kv1.3--Potentially New Molecular Target in Cancer Diagnostics and Therapy. 38
26467143 2015
12
Secretogranin II is overexpressed in advanced prostate cancer and promotes the neuroendocrine differentiation of prostate cancer cells. 38
25307750 2014
13
Linac-based stereotactic body radiotherapy for oligometastatic patients with single abdominal lymph node recurrent cancer. 38
22992626 2014
14
Discovering hidden connections among diseases, genes and drugs based on microarray expression profiles with negative-term filtering. 38
24915461 2014
15
Outcomes of cervical lymph node recurrence in patients with esophageal squamous cell carcinoma after esophagectomy with 2-field lymph node dissection. 38
23422046 2013
16
Mucoepidermoid carcinoma of the parotid gland: factors affecting outcome. 38
20629088 2011
17
[Cancer statistics of ┼×─▒rnak city]. 38
21935873 2011
18
Diagnosis of primary versus metastatic ovarian adenocarcinoma using p53 gene mutation analysis. 38
20514505 2010
19
Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells. 38
20392890 2010
20
Biodistributions of 177Lu- and 111In-labeled 7E11 antibodies to prostate-specific membrane antigen in xenograft model of prostate cancer and potential use of 111In-7E11 as a pre-therapeutic agent for 177Lu-7E11 radioimmunotherapy. 38
19034582 2009
21
A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer. 38
17923812 2007
22
[Successful immunotherapy combined with hyperthermia therapy for cancer patients]. 38
17212092 2006
23
[A case of carcinoma with sarcomatoid elements in the middle mediastinum]. 38
16886806 2006
24
Development of high-sensitivity near-infrared fluorescence imaging device for early cancer detection. 38
15742853 2005
25
p53 alteration in regional lymph node metastases from prostate carcinoma: a marker for progression? 38
10357418 1999
26
[Mediastinal lymph-node carcinoma with no apparent primary lesion]. 38
9259132 1997
27
Lymph node cancer of the mediastinal or hilar region with an unknown primary site. 38
7898117 1995
28
[Standardized incidence ratios for cancers in Taiwan aborigines, 1981-1987]. 38
8089874 1994
29
S-100+ lymph node neoplasm. Report of a case with histological AL and immunological features intermediate between T cell lymphoma and malignant histiocytosis. 38
6437069 1984
30
CT of cervical lymph node cancer. 38
6781263 1981
31
[Accuracy of lymphography in carcinoma of the cervix (author's transl)]. 38
494871 1979

Variations for Lymph Node Cancer

Expression for Lymph Node Cancer

Search GEO for disease gene expression data for Lymph Node Cancer.

Pathways for Lymph Node Cancer

Pathways related to Lymph Node Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 PLAUR IGFBP3 IGF1R FOS
2
Show member pathways
12.37 TP53 IGF1R FOS CSF2
3 12.05 TP53 PLAUR FOS
4 11.97 TP53 FOS CSF2
5 11.89 TP53 PLAUR IGF1R
6
Show member pathways
11.64 TP53 IGFBP3 IGF1R FOS
7 11.46 TP53 IGFBP3 IGF1R
8 11.25 TP53 FOS CSF2
9 11.23 TP53 FOS
10 11.19 FOS CSF2
11 11.19 TP53 IGFBP3 IGF1R CSF2
12 11.17 PLAUR FOS
13 11 TP53 IGFBP3

GO Terms for Lymph Node Cancer

Cellular components related to Lymph Node Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.8 SCG2 PLAUR IGFBP3

Biological processes related to Lymph Node Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.43 TP53 FOS CSF2
2 protein tetramerization GO:0051262 9.16 TP53 IGF1R
3 positive regulation of release of cytochrome c from mitochondria GO:0090200 8.96 TP53 PLAUR
4 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.62 TP53 FOS

Molecular functions related to Lymph Node Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor binding GO:0005520 8.96 IGFBP3 IGF1R
2 insulin-like growth factor I binding GO:0031994 8.62 IGFBP3 IGF1R

Sources for Lymph Node Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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