MCID: LYM157
MIFTS: 29

Lymph Node Carcinoma

Categories: Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Lymph Node Carcinoma

MalaCards integrated aliases for Lymph Node Carcinoma:

Name: Lymph Node Carcinoma 12 15
Lymph Node Neoplasm 12 20
Lymph Node Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080618 DOID:10619
NCIt 50 C35497
SNOMED-CT 67 127232002
UMLS 71 C0596869

Summaries for Lymph Node Carcinoma

Disease Ontology : 12 A lymphatic system cancer that is located in the lymph node.

MalaCards based summary : Lymph Node Carcinoma, also known as lymph node neoplasm, is related to lymph node adenoid cystic carcinoma and lymphoma, hodgkin, classic. An important gene associated with Lymph Node Carcinoma is LRRC26 (Leucine Rich Repeat Containing 26). Affiliated tissues include lymph node, prostate and breast.

Related Diseases for Lymph Node Carcinoma

Diseases related to Lymph Node Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 lymph node adenoid cystic carcinoma 11.2
2 lymphoma, hodgkin, classic 11.1
3 prostate adenoid cystic carcinoma 10.0 KLK3 AR
4 prostate leiomyoma 10.0 KLK3 AR
5 prostate calculus 10.0 KLK3 AR
6 pancytopenia 10.0
7 fibrosarcoma of bone 10.0
8 histiocytosis 10.0
9 splenomegaly 10.0
10 nodular prostate 10.0 KLK3 AR
11 bronchiectasis 3 10.0 KLK3 AR
12 prostatic acinar adenocarcinoma 9.9 KLK3 AR
13 lung cancer susceptibility 3 9.9
14 large cell neuroendocrine carcinoma 9.9
15 nodal marginal zone lymphoma 9.9
16 neuroendocrine carcinoma 9.9
17 endodermal sinus tumor 9.9
18 rectum cancer 9.9
19 adenocarcinoma 9.9
20 papillary adenocarcinoma 9.9
21 tubular adenocarcinoma 9.9
22 testicular yolk sac tumor 9.9
23 mycobacterium tuberculosis 1 9.9
24 small cell carcinoma 9.9
25 prostate transitional cell carcinoma 9.9 KLK3 AR
26 male reproductive organ benign neoplasm 9.9 KLK3 AR
27 prostatic adenoma 9.9 KLK3 AR
28 lymphocele 9.8 KLK3 FOLH1
29 withdrawal disorder 9.8 KLK3 AR
30 urethral stricture 9.8 KLK3 FOLH1
31 bladder lateral wall cancer 9.8 KLK3 FOLH1
32 androgenic alopecia 9.8 KLK3 AR
33 prostatic hyperplasia, benign 9.8 KLK3 FOLH1 AR
34 prostate neuroendocrine neoplasm 9.8 KLK3 FOLH1 AR
35 suppression of tumorigenicity 12 9.7 KLK3 FOLH1 AR
36 sexual disorder 9.7 KLK3 KCNMA1 AR
37 villous adenoma 9.7 KLK3 FOLH1
38 prostatic hypertrophy 9.6 KLK3 AR

Graphical network of the top 20 diseases related to Lymph Node Carcinoma:



Diseases related to Lymph Node Carcinoma

Symptoms & Phenotypes for Lymph Node Carcinoma

Drugs & Therapeutics for Lymph Node Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Feasibility Study of High Dose Stereotactic Body Radiation Therapy (SBRT) for Lymph Nodal Lesions in Oligometastatic Patients for Genito-urinary, Gastro-intestinal and Gynaecological Cancer Active, not recruiting NCT02570399

Search NIH Clinical Center for Lymph Node Carcinoma

Genetic Tests for Lymph Node Carcinoma

Anatomical Context for Lymph Node Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Lymph Node Carcinoma:

19
Lymph Node

MalaCards organs/tissues related to Lymph Node Carcinoma:

40
Lymph Node, Prostate, Breast, Brain, Skin

Publications for Lymph Node Carcinoma

Articles related to Lymph Node Carcinoma:

(show top 50) (show all 97)
# Title Authors PMID Year
1
Val16A SOD2 Polymorphism Promotes Epithelial-Mesenchymal Transition Antagonized by Muscadine Grape Skin Extract in Prostate Cancer Cells. 61
33535682 2021
2
The Effect of Arbutin on The Expression of Tumor Suppressor P53, BAX/BCL-2 Ratio and Oxidative Stress Induced by Tert-Butyl Hydroperoxide in Fibroblast and LNcap Cell Lines. 61
32347047 2021
3
Epigallocatechin-3-gallate Enhances the Efficacy of MicroRNA-34a Mimic and MicroRNA-93 Inhibitor Co-transfection in Prostate Cancer Cell Line. 61
33463130 2020
4
Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like Characteristics. 61
33339129 2020
5
Roles of Interleukin-1 Receptor Antagonist in Prostate Cancer Progression. 61
33322099 2020
6
CD147 promotes epithelial-mesenchymal transition of prostate cancer cells via the Wnt/β-catenin pathway. 61
32855684 2020
7
Preliminary in Vitro Studies on Corynebacterium urealyticum Pathogenetic Mechanisms, a Possible Candidate for Chronic Idiopathic Prostatitis? 61
32218312 2020
8
Development of Novel PSMA Ligands for Imaging and Therapy with Copper Isotopes. 61
31541034 2020
9
miR-100-5p Downregulates mTOR to Suppress the Proliferation, Migration, and Invasion of Prostate Cancer Cells. 61
33335853 2020
10
Modelling the internalisation process of prostate cancer cells for PSMA-specific ligands. 61
31260881 2019
11
Radiopotentiation of enzalutamide over human prostate cancer cells as assessed by real-time cell monitoring. 61
30858765 2019
12
A Case of Mediastinal Lymph Node Carcinoma of Unknown Primary Site. 61
30488402 2018
13
Development of pipette tip gap closure migration assay (s-ARU method) for studying semi-adherent cell lines. 61
30069611 2018
14
Meta-analysis of survival benefit with postoperative chemoradiotherapy in patients of lymph node positive esophageal carcinoma. 61
29143229 2018
15
Cervical lymph node carcinoma metastasis from unknown primary site: a retrospective analysis of 154 patients. 61
29608251 2018
16
Genome-Wide Methylation Patterns in Androgen-Independent Prostate Cancer Cells: A Comprehensive Analysis Combining MeDIP-Bisulfite, RNA, and microRNA Sequencing Data. 61
29324665 2018
17
Anticancer effect of Saussurea lappa extract via dual control of apoptosis and autophagy in prostate cancer cells. 61
28746210 2017
18
Preclinical Evaluation of 18F-PSMA-1007, a New Prostate-Specific Membrane Antigen Ligand for Prostate Cancer Imaging. 61
27789722 2017
19
Amiloride Is Effective in the Management of Abiraterone-Induced Mineralocorticoid Excess Syndrome without Interfering with Its Antineoplastic Activity. 61
28797006 2017
20
Superporous Poly(ethylene glycol) Diacrylate Cryogel with a Defined Elastic Modulus for Prostate Cancer Cell Research. 61
27240250 2016
21
Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle. 61
26991550 2016
22
Hibiscus sabdariffa Leaf Extract Inhibits Human Prostate Cancer Cell Invasion via Down-Regulation of Akt/NF-kB/MMP-9 Pathway. 61
26115086 2015
23
Regulation of T-type calcium channel expression by sodium butyrate in prostate cancer cells. 61
25557765 2015
24
ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells. 61
25492003 2015
25
Acridone alkaloids with cytotoxic and antimalarial activities from Zanthoxylum simullans Hance. 61
24696549 2014
26
[Metastatic thoracic lymph node carcinoma from extra-thoracic malignancy or from unknown primary site]. 61
24210159 2013
27
Relapsed cervicomediastinal lymph node carcinoma with an unknown primary site treated with TS-1 alone: a case report. 61
24370171 2013
28
Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. 61
24167294 2013
29
[Mediastinal lymph node carcinoma of unknown primary site; report of a case]. 61
23917060 2013
30
CT-guided percutaneous chemoablation using an ethanol-ethiodol-doxorubicin emulsion for the treatment of metastatic lymph node carcinoma: a comparative study. 61
22905808 2013
31
Integration of the transcriptome and glycome for identification of glycan cell signatures. 61
23326219 2013
32
In vivo pH imaging with (99m)Tc-pHLIP. 61
22371188 2012
33
Effect of lithium chloride and antineoplastic drugs on survival and cell cycle of androgen-dependent prostate cancer LNCap cells. 61
23248400 2012
34
[Mediastinal lymph node carcinoma of unknown primary site; report of a case]. 61
22647337 2012
35
Multimodal treatment for multistation mediastinal lymph node adenocarcinoma: a case report. 61
22001212 2012
36
A case of mediastinal lymph node carcinoma of unknown primary site treated with docetaxel and cisplatin with concurrent thoracic radiation therapy. 61
22189482 2011
37
[Experience of long term survival in a case with surgery for cancer metastasis to brain and mediastinal lymph node from unknown primary site]. 61
21766710 2011
38
Lovastatin causes diminished PSA secretion by inhibiting AR expression and function in LNCaP prostate cancer cells. 61
21624609 2011
39
Forkhead box protein A1 regulates UDP-glucuronosyltransferase 2B15 gene transcription in LNCaP prostate cancer cells. 61
20736324 2010
40
Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells. 61
19747763 2010
41
Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. 61
20574928 2010
42
The bioactive compounds alpha-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells. 61
20574921 2010
43
Mediastinal lymph node carcinoma of an unknown primary site: clinicopathological examination. 61
19440819 2009
44
Anti-androgenic activity of fatty acids. 61
19353546 2009
45
Prostate-specific membrane antigen and its truncated form PSM'. 61
19107881 2009
46
[Mediastinal lymph node carcinoma of unknown primary site; report of a case]. 61
19280962 2009
47
Anti-androgen effects of extracts and compounds from Ganoderma lucidum. 61
19235153 2009
48
Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression. 61
19017637 2009
49
Induction of apoptosis by lupeol and mango extract in mouse prostate and LNCaP cells. 61
18444143 2008
50
Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells. 61
18444160 2008

Variations for Lymph Node Carcinoma

Expression for Lymph Node Carcinoma

Search GEO for disease gene expression data for Lymph Node Carcinoma.

Pathways for Lymph Node Carcinoma

GO Terms for Lymph Node Carcinoma

Cellular components related to Lymph Node Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 TRPC1 TCAF1 LRRC55 LRRC52 LRRC38 LRRC26
2 integral component of plasma membrane GO:0005887 9.5 TRPC1 LRRC55 LRRC52 LRRC38 LRRC26 KCNMB4
3 voltage-gated potassium channel complex GO:0008076 9.1 LRRC55 LRRC52 LRRC38 LRRC26 KCNMB4 KCNMA1

Biological processes related to Lymph Node Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.76 TRPC1 LRRC55 LRRC52 LRRC38 LRRC26 KCNU1
2 potassium ion transport GO:0006813 9.56 LRRC52 KCNU1 KCNMB4 KCNMA1
3 regulation of systemic arterial blood pressure GO:0003073 9.37 KLK3 AR
4 reproductive process GO:0022414 9.32 LRRC52 KCNU1
5 positive regulation of voltage-gated potassium channel activity GO:1903818 9.26 LRRC55 LRRC52 LRRC38 LRRC26
6 potassium ion transmembrane transport GO:0071805 9.17 LRRC55 LRRC52 LRRC38 LRRC26 KCNU1 KCNMB4

Molecular functions related to Lymph Node Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.58 TRPC1 KCNU1 KCNMA1
2 voltage-gated potassium channel activity GO:0005249 9.55 LRRC55 LRRC52 LRRC38 LRRC26 KCNMA1
3 potassium channel activity GO:0005267 9.5 LRRC52 KCNU1 KCNMA1
4 ion channel binding GO:0044325 9.43 TRPC1 TCAF1 LRRC55 LRRC52 LRRC38 LRRC26
5 calcium-activated potassium channel activity GO:0015269 9.37 KCNMB4 KCNMA1
6 large conductance calcium-activated potassium channel activity GO:0060072 9.26 KCNU1 KCNMA1
7 potassium channel activator activity GO:0099104 8.92 LRRC55 LRRC52 LRRC38 LRRC26

Sources for Lymph Node Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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