MCID: LYM157
MIFTS: 34

Lymph Node Carcinoma

Categories: Cancer diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Lymph Node Carcinoma

MalaCards integrated aliases for Lymph Node Carcinoma:

Name: Lymph Node Carcinoma 11 14
Lymph Node Cancer 11 14 71
Lymph Node Neoplasm 11 19
Neoplasm of Lymph Node 71

Classifications:



External Ids:

Disease Ontology 11 DOID:0080618 DOID:10619
NCIt 49 C35497
SNOMED-CT 68 127232002
UMLS 71 C0596869 C0948627

Summaries for Lymph Node Carcinoma

Disease Ontology 11 Lymph node carcinoma: A lymph node cancer that has material basis in abnormally proliferating cells derives from epithelial cells.

Lymph node cancer: A lymphatic system cancer that is located in the lymph node.

MalaCards based summary: Lymph Node Carcinoma, also known as lymph node cancer, is related to lymph node adenoid cystic carcinoma and lymphoma, hodgkin, classic. An important gene associated with Lymph Node Carcinoma is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways is TRP channels. The drugs Nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include lymph node, prostate and breast.

Related Diseases for Lymph Node Carcinoma

Diseases related to Lymph Node Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 lymph node adenoid cystic carcinoma 11.2
2 lymphoma, hodgkin, classic 11.2
3 prostate adenoid cystic carcinoma 10.3 KLK3 AR
4 prostate leiomyoma 10.2 KLK3 AR
5 prostate calculus 10.2 KLK3 AR
6 mediastinal cancer 10.2
7 nodular prostate 10.2 KLK3 FOLH1
8 lymphocele 10.2 KLK3 FOLH1
9 prostatic acinar adenocarcinoma 10.2 KLK3 FOLH1 AR
10 prostate small cell carcinoma 10.2 KLK3 FOLH1 AR
11 prostatic hyperplasia, benign 10.2 KLK3 FOLH1 AR
12 prostate neuroendocrine neoplasm 10.2 KLK3 FOLH1 AR
13 castration-resistant prostate carcinoma 10.2 KLK3 FOLH1 AR
14 prostatic hypertrophy 10.2 KLK3 FOLH1 AR
15 primary cutaneous amyloidosis 10.2 KLK3 FOLH1 AR
16 male reproductive organ benign neoplasm 10.1 KLK3 AR
17 testicular disease 10.1 KLK3 H2AC18 AR
18 sexual health disorder 10.1 H2AC18 AR
19 urethral stricture 10.1 KLK3 FOLH1
20 suppression of tumorigenicity 12 10.1 KLK3 H2AC18 FOLH1 AR
21 prostatic adenoma 10.0 KLK3 AR
22 male reproductive organ cancer 10.0 KLK3 H2AC18 FOLH1 AR
23 familial episodic pain syndrome 10.0 TRPM8 TRPM4
24 prostate disease 10.0 KLK3 H2AC18 FOLH1 AR
25 male reproductive system disease 10.0 KLK3 H2AC18 FOLH1 AR
26 telogen effluvium 10.0 OR2AT4 AR
27 aplastic anemia 10.0
28 histiocytic sarcoma 10.0
29 pancytopenia 10.0
30 fibrosarcoma of bone 10.0
31 histiocytosis 10.0
32 splenomegaly 10.0
33 lymphoma, mucosa-associated lymphoid type 9.9
34 lung cancer susceptibility 3 9.9
35 large cell neuroendocrine carcinoma 9.9
36 head and neck cancer 9.9
37 neuroendocrine carcinoma 9.9
38 endodermal sinus tumor 9.9
39 rectal benign neoplasm 9.9
40 rectum cancer 9.9
41 adenocarcinoma 9.9
42 papillary adenocarcinoma 9.9
43 tubular adenocarcinoma 9.9
44 colorectal cancer 9.9
45 factor vii deficiency 9.9
46 small cell carcinoma 9.9
47 colonic benign neoplasm 9.9
48 larynx cancer 9.9
49 laryngeal benign neoplasm 9.9
50 lung benign neoplasm 9.9

Graphical network of the top 20 diseases related to Lymph Node Carcinoma:



Diseases related to Lymph Node Carcinoma

Symptoms & Phenotypes for Lymph Node Carcinoma

Drugs & Therapeutics for Lymph Node Carcinoma

Drugs for Lymph Node Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3 Immunoglobulins Phase 2
4 Immune Checkpoint Inhibitors Phase 2
5 Antibodies Phase 2
6 Antineoplastic Agents, Immunological Phase 2
7
Pancrelipase Approved, Investigational 53608-75-6 8519
8 Pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Phase II Study of TLR9 Agonist CMP-001 in Combination With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease Active, not recruiting NCT03618641 Phase 2 CMP-001
2 A Randomised Controlled Trial Comparing PICO™ Single Use Negative Pressure Wound Therapy System (Smith & Nephew Healthcare Limited, UK) to Conventional Wound Care Following Inguinal Lymphadenectomy for Metastatic Cutaneous Malignancy Unknown status NCT02408835
3 Videoscopic Ilioinguinal Lymphadenectomy for Groin Lymph Node Metastases From Melanoma Completed NCT02508909
4 Real-time Semi-quantification of Endoscopic Ultrasound Elastography and Contrast-enhancement Using Strain Histograms (SH) and Contrast-enhancement (CE) for the Differentiation of Focal Pancreatic Masses and the Assessment of Lymph Node Involvement Completed NCT02459041
5 Lymph Node Involvement Using Extended Pelvic Lymphadenectomy in Clinically Localized Prostate Cancer in Bogota Colombia. Completed NCT02156414
6 Tissue Characterisation Using Ultrasound Based Strain Imaging(Elastography)Examining Lesions in the Gastrointestinal Wall, Adjacent Lymph Nodes and Pancreatic Lesions Completed NCT01360411
7 Survey of Extremity and Trunk Sarcoma Surgeons Regarding Surgical Management of Lymph Node Basins Recruiting NCT04553744
8 Axillary Reverse Mapping (ARM): Validation of Surgical Tecnique in Breast Cancer Surgery Recruiting NCT05040685
9 Feasibility Study of High Dose Stereotactic Body Radiation Therapy (SBRT) for Lymph Nodal Lesions in Oligometastatic Patients for Genito-urinary, Gastro-intestinal and Gynaecological Cancer Active, not recruiting NCT02570399
10 Quantitative Analysis of 18F-FAPI Dynamic PET/CT for Accurate Differential Diagnosis of Metastatic Lymph Nodes of Esophageal Squamous Cell Carcinoma Not yet recruiting NCT05287880

Search NIH Clinical Center for Lymph Node Carcinoma

Genetic Tests for Lymph Node Carcinoma

Anatomical Context for Lymph Node Carcinoma

Organs/tissues related to Lymph Node Carcinoma:

FMA: Lymph Node
MalaCards : Lymph Node, Prostate, Breast, Cervix, Testis, Lung, Cortex

Publications for Lymph Node Carcinoma

Articles related to Lymph Node Carcinoma:

(show top 50) (show all 141)
# Title Authors PMID Year
1
A novel biorecognition receptor Citropin-A modified impedimetric biosensor for detection of LNCaP prostate cancer cells. 62
35688260 2022
2
Connarus semidecandrus Jack Exerts Anti-Alopecia Effects by Targeting 5α-Reductase Activity and an Intrinsic Apoptotic Pathway. 62
35807332 2022
3
Axillary lymph-node metastases as the primary presentation of high-grade serous ovarian carcinoma: A case report. 62
35441016 2022
4
Prostate-specific membrane antigen (PSMA) targeted singlet oxygen delivery via endoperoxide tethered ligands. 62
35029263 2022
5
Refined Chelator Spacer Moieties Ameliorate the Pharmacokinetics of PSMA-617. 62
36017165 2022
6
Inflammation induced by lipopolysaccharide advanced androgen receptor expression and epithelial-mesenchymal transition progress in prostatitis and prostate cancer. 62
34984192 2021
7
A case of early gastric cancer with a single giant lymph node metastasis. 62
34792649 2021
8
Preserving the posterior cortex of the sternum during resection of a superficial anterior chest wall sarcoma. 62
34729167 2021
9
Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19. 62
34413211 2021
10
Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis. 62
34294701 2021
11
Standardization of the [68Ga]Ga-PSMA-11 Radiolabeling Protocol in an Automatic Synthesis Module: Assessments for PET Imaging of Prostate Cancer. 62
33918987 2021
12
Val16A SOD2 Polymorphism Promotes Epithelial-Mesenchymal Transition Antagonized by Muscadine Grape Skin Extract in Prostate Cancer Cells. 62
33535682 2021
13
Comprehensive analysis of metastatic gastric cancer tumour cells using single-cell RNA-seq. 62
33441952 2021
14
Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line. 62
33640452 2021
15
The Effect of Arbutin on The Expression of Tumor Suppressor P53, BAX/BCL-2 Ratio and Oxidative Stress Induced by Tert-Butyl Hydroperoxide in Fibroblast and LNcap Cell Lines. 62
32347047 2021
16
Epigallocatechin-3-gallate Enhances the Efficacy of MicroRNA-34a Mimic and MicroRNA-93 Inhibitor Co-transfection in Prostate Cancer Cell Line. 62
33463130 2020
17
Roles of Interleukin-1 Receptor Antagonist in Prostate Cancer Progression. 62
33322099 2020
18
Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like Characteristics. 62
33339129 2020
19
CD147 promotes epithelial-mesenchymal transition of prostate cancer cells via the Wnt/β-catenin pathway. 62
32855684 2020
20
Analysis of novel enzalutamide-resistant cells: upregulation of testis-specific Y-encoded protein gene promotes the expression of androgen receptor splicing variant 7. 62
35117234 2020
21
Magnetic resonance imaging and photothermal conversion properties of Gd-C nanocomposites for interstitial lymphography. 62
31099983 2020
22
Preliminary in Vitro Studies on Corynebacterium urealyticum Pathogenetic Mechanisms, a Possible Candidate for Chronic Idiopathic Prostatitis? 62
32218312 2020
23
Development of Novel PSMA Ligands for Imaging and Therapy with Copper Isotopes. 62
31541034 2020
24
A spatial neighborhood methodology for computing and analyzing lymph node carcinoma similarity in precision medicine. 62
34417010 2020
25
miR-100-5p Downregulates mTOR to Suppress the Proliferation, Migration, and Invasion of Prostate Cancer Cells. 62
33335853 2020
26
Modelling the internalisation process of prostate cancer cells for PSMA-specific ligands. 62
31260881 2019
27
Radiopotentiation of enzalutamide over human prostate cancer cells as assessed by real-time cell monitoring. 62
30858765 2019
28
Raman spectroscopy discriminates malignant follicular lymphoma from benign follicular hyperplasia and from tumour metastasis. 62
30609603 2019
29
A Case of Mediastinal Lymph Node Carcinoma of Unknown Primary Site. 62
30488402 2018
30
Development of pipette tip gap closure migration assay (s-ARU method) for studying semi-adherent cell lines. 62
30069611 2018
31
Meta-analysis of survival benefit with postoperative chemoradiotherapy in patients of lymph node positive esophageal carcinoma. 62
29143229 2018
32
Cervical lymph node carcinoma metastasis from unknown primary site: a retrospective analysis of 154 patients. 62
29608251 2018
33
Lymph node cancer of the mediastinum with a putative necrotic primary lesion in the lung: a case report. 62
29606126 2018
34
Genome-Wide Methylation Patterns in Androgen-Independent Prostate Cancer Cells: A Comprehensive Analysis Combining MeDIP-Bisulfite, RNA, and microRNA Sequencing Data. 62
29324665 2018
35
[Long-Term Survival of a Patient with Metastatic Liver and Para-Aortic Lymph Node Cancer from Colon Cancer Treated with Regorafenib]. 62
29394758 2017
36
Anticancer effect of Saussurea lappa extract via dual control of apoptosis and autophagy in prostate cancer cells. 62
28746210 2017
37
[The Diagnostic Value of Endobronchial Ultrasound-guided Needle Aspiration Biopsy for Lung or Mediastinal Lymph Node Cancer and Tuberculosis]. 62
28616904 2017
38
Preclinical Evaluation of 18F-PSMA-1007, a New Prostate-Specific Membrane Antigen Ligand for Prostate Cancer Imaging. 62
27789722 2017
39
Amiloride Is Effective in the Management of Abiraterone-Induced Mineralocorticoid Excess Syndrome without Interfering with Its Antineoplastic Activity. 62
28797006 2017
40
Superporous Poly(ethylene glycol) Diacrylate Cryogel with a Defined Elastic Modulus for Prostate Cancer Cell Research. 62
27240250 2016
41
Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle. 62
26991550 2016
42
A comparison of novel organoiridium(III) complexes and their ligands as a potential treatment for prostate cancer. 62
26802546 2016
43
Formation of Tethers from Spreading Cellular Aggregates. 62
26509898 2015
44
Is Stereotactic Body Radiotherapy (SBRT) in lymph node oligometastatic patients feasible and effective? 62
26696788 2015
45
Physical diseases as predictors of suicide in older adults: a nationwide, register-based cohort study. 62
25835959 2015
46
The overview of cancer patients attending in a specialized hospital: A cross sectional study. 62
29624288 2015
47
Hibiscus sabdariffa Leaf Extract Inhibits Human Prostate Cancer Cell Invasion via Down-Regulation of Akt/NF-kB/MMP-9 Pathway. 62
26115086 2015
48
Voltage-Gated Potassium Channels Kv1.3--Potentially New Molecular Target in Cancer Diagnostics and Therapy. 62
26467143 2015
49
Regulation of T-type calcium channel expression by sodium butyrate in prostate cancer cells. 62
25557765 2015
50
ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells. 62
25492003 2015

Variations for Lymph Node Carcinoma

Expression for Lymph Node Carcinoma

Search GEO for disease gene expression data for Lymph Node Carcinoma.

Pathways for Lymph Node Carcinoma

Pathways related to Lymph Node Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.25 TRPM8 TRPM4 TRPC1

GO Terms for Lymph Node Carcinoma

Cellular components related to Lymph Node Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 TRPM8 TRPM4 TRPC1 LRRC55 LRRC52 LRRC38
2 plasma membrane GO:0005887 9.7 TRPM8 TRPM4 TRPC1 LRRC55 LRRC52 LRRC38
3 voltage-gated potassium channel complex GO:0008076 9.56 LRRC55 LRRC52 LRRC38 LRRC26

Biological processes related to Lymph Node Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion transmembrane transport GO:0071805 9.76 LRRC55 LRRC52 LRRC38 LRRC26
2 regulation of systemic arterial blood pressure GO:0003073 9.56 KLK3 AR
3 monoatomic ion transport GO:0006811 9.5 TRPM8 TRPM4 TRPC1 LRRC55 LRRC52 LRRC38
4 positive regulation of voltage-gated potassium channel activity GO:1903818 9.23 LRRC55 LRRC52 LRRC38 LRRC26

Molecular functions related to Lymph Node Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium channel activity GO:0005262 9.77 TRPM8 TRPM4 TRPC1
2 voltage-gated potassium channel activity GO:0005249 9.76 LRRC26 LRRC38 LRRC52 LRRC55
3 monoatomic cation channel activity GO:0005261 9.73 TRPM8 TRPM4 TRPC1
4 transmembrane transporter binding GO:0044325 9.65 TCAF1 LRRC55 LRRC52 LRRC38 LRRC26
5 ligand-gated calcium channel activity GO:0099604 9.62 TRPM8 TRPM4
6 potassium channel activator activity GO:0099104 9.23 LRRC55 LRRC52 LRRC38 LRRC26

Sources for Lymph Node Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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