MCID: LYM116
MIFTS: 43

Lymph Node Disease

Categories: Immune diseases
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Aliases & Classifications for Lymph Node Disease

MalaCards integrated aliases for Lymph Node Disease:

Name: Lymph Node Disease 11 14
Abnormality of the Lymph Nodes 5
Disorder of Lymph Node 71

Classifications:



External Ids:

Disease Ontology 11 DOID:9942
NCIt 49 C35346
SNOMED-CT 68 76616003
UMLS 71 C0272394

Summaries for Lymph Node Disease

MalaCards based summary: Lymph Node Disease, also known as abnormality of the lymph nodes, is related to persistent generalized lymphadenopathy and lymphadenitis, and has symptoms including axillary lymph node pain, inguinal lymph node pain and inguinal lymph node tenderness. An important gene associated with Lymph Node Disease is NF1 (Neurofibromin 1), and among its related pathways/superpathways are glycolysis (BioCyc) and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Letrozole and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and pancreas, and related phenotypes are homeostasis/metabolism and neoplasm

Related Diseases for Lymph Node Disease

Diseases related to Lymph Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 961)
# Related Disease Score Top Affiliating Genes
1 persistent generalized lymphadenopathy 32.1 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
2 lymphadenitis 32.0 TNF SERPINA3 MIR223 ITPKC IL6 ICOSLG
3 meningitis 30.4 TNF IL6 CRP ALB
4 penile cancer 30.4 MIR223 CD8A CD4
5 castleman disease 30.4 IL6 H2AC18 CRP CD4 CCR6
6 bronchitis 30.3 TNF IL6 CRP ALB
7 kidney cancer 30.3 SDHB ICOSLG H2AC18 CCR6
8 lymphatic system disease 30.1 SERPINA3 MIR483 MIR223 ICOSLG H2AC18 CD8A
9 esophageal cancer 29.8 TNF MIR483 MIR223 IL6 ICOSLG H2AC18
10 histiocytosis 10.5 TNF SERPINA3 CCR6
11 sporadic pheochromocytoma/secreting paraganglioma 10.5 SDHD SDHB
12 purpura 10.5 TNF IL6 CRP
13 myelitis 10.5 TNF IL6 CCR6
14 hilar lung neoplasm 10.5 CD8A CD4
15 duodenal somatostatinoma 10.5 TMEM127 SDHAF2 NF1
16 leiomyoma cutis 10.5 SDHD SDHB SDHA
17 external pathological resorption 10.5 TNF IL6
18 dermis tumor 10.5 SDHD SDHB SDHA
19 paragangliomas 4 10.5 SDHD SDHB
20 foster-kennedy syndrome 10.5 SDHD SDHAF2 SDHA
21 enterocolitis 10.5 TNF IL6 CRP
22 scrotum melanoma 10.5 SDHD SDHA
23 cystitis 10.5 TNF IL6 CRP
24 carotid body cancer 10.5 SDHD SDHB
25 glomus tumor 10.5 SDHD SDHB NF1
26 orbital disease 10.5 NF1 CRP CD4
27 syphilitic meningitis 10.5 CRP CD4
28 thyroiditis 10.5 TNF IL6 CRP
29 multiple mucosal neuroma 10.5 TMEM127 NF1
30 atypical depressive disorder 10.5 SERPINA3 IL6 CRP
31 sapho syndrome 10.5 TNF CRP CCR6
32 horner's syndrome 10.5 SDHD SDHB NF1 CRP
33 chronic duodenal ileus 10.5 CRP ALB
34 enthesopathy 10.4 TNF CRP CCR6
35 peripheral nerve schwannoma 10.4 SERPINA3 NF1
36 ventilation pneumonitis 10.4 CRP CD8A CD4
37 multiple endocrine neoplasia 10.4 SDHD SDHC SDHB NF1
38 pollen allergy 10.4 ICOSLG CD4 CCR6
39 gastric liposarcoma 10.4 SDHD SDHB SDHA NF1
40 oral tuberculosis 10.4 CD8A CD4
41 legume allergy 10.4 ICOSLG CD4 CCR6
42 fruit allergy 10.4 ICOSLG CD4 CCR6
43 pericardial tuberculosis 10.4 TNF CRP CD4
44 early yaws 10.4 CD8A CD4
45 hydrops of gallbladder 10.4 ITPKC CRP ALB
46 chronic pyelonephritis 10.4 SERPINA3 CRP ALB
47 spongiotic dermatitis 10.4 CD8A CD4 CCR6
48 optic papillitis 10.4 TNF CRP CD4
49 suppurative lymphadenitis 10.4 CRP CD8A CD4
50 impetigo 10.4 SERPINA3 IL6 CCR6

Graphical network of the top 20 diseases related to Lymph Node Disease:



Diseases related to Lymph Node Disease

Symptoms & Phenotypes for Lymph Node Disease

UMLS symptoms related to Lymph Node Disease:


axillary lymph node pain; inguinal lymph node pain; inguinal lymph node tenderness

MGI Mouse Phenotypes related to Lymph Node Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ALB CCR6 CD4 CRP ICOSLG IL6
2 neoplasm MP:0002006 9.8 ALB IL6 NF1 SDHB SDHC SDHD
3 immune system MP:0005387 9.8 ALB CCR6 CD4 CD8A CRP ICOSLG
4 hematopoietic system MP:0005397 9.47 CCR6 CD4 CD8A ICOSLG IL6 ITPKC

Drugs & Therapeutics for Lymph Node Disease

Drugs for Lymph Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
2
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
3
Tamoxifen Approved Phase 3 10540-29-1, 54965-24-1 2733526
4
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
5
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
6 Antineoplastic Agents, Hormonal Phase 3
7 Estrogens Phase 3
8 Estrogen Receptor Modulators Phase 3
9 Estrogen Receptor Antagonists Phase 3
10 Estrogen Antagonists Phase 3
11 Hormones Phase 3
12 Antimitotic Agents Phase 3
13 Antimetabolites Phase 3
14 Hormone Antagonists Phase 3
15 Tubulin Modulators Phase 3
16 Aromatase Inhibitors Phase 3
17 Selective Estrogen Receptor Modulators Phase 3
18
Nivolumab Approved Phase 2 946414-94-4
19
Ipilimumab Approved Phase 2 477202-00-9
20 Immunoglobulins Phase 2
21 Immune Checkpoint Inhibitors Phase 2
22 Antibodies Phase 2
23 Antineoplastic Agents, Immunological Phase 2
24
Pancrelipase Approved, Investigational 53608-75-6 8519
25
Imidacloprid Vet_approved 105827-78-9 86418
26 Pancreatin

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Randomised Clinical Trial of Surgery Versus Surgery Plus Adjuvant Radiotherapy for Regional Control in Patients With Completely Resected Macroscopic Nodal Metastatic Melanoma Completed NCT00287196 Phase 3
2 MINDACT (Microarray In Node-Negative and 1 to 3 Positive Lymph Node Disease May Avoid Chemotherapy): A Prospective, Randomized Study Comparing the 70-Gene Signature With the Common Clinical-Pathological Criteria in Selecting Patients for Adjuvant Chemotherapy in Breast Cancer With 0 to 3 Positive Nodes Completed NCT00433589 Phase 3 anthracycline-based;docetaxel and capecitabine;tamoxifen;Letrozole
3 A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy Active, not recruiting NCT01901094 Phase 3
4 Neoadjuvant Phase II Study of TLR9 Agonist CMP-001 in Combination With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease Active, not recruiting NCT03618641 Phase 2 CMP-001
5 Investigating the Feasibility of Fluorescence Targeted Pelvic Lymph Node Mapping During Rectal Cancer Surgery Terminated NCT03204994 Phase 1, Phase 2 Indocyanine Green
6 Role of Color Doppler Ultrasound in Differentiation Between Benign and Malignant Lymphadenopathy Unknown status NCT03760094
7 Prediction Model Based on Deep Learning of CP-EBUS Multimodal Image in the Diagnosis of Benign and Malignant Lymph Nodes Unknown status NCT04328792
8 Prospective Analysis of the Survival of Patients With a Reduction in the Number of Lymph Nodes in Rectal Cancer After Neoadjuvant Chemoradiotherapy Unknown status NCT04456283
9 Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®) in Tumors of the Pancreas, Submucosal Tumors and Lymph Node Disease of the Upper GI Tract Unknown status NCT03621852
10 Retrospektive Analyse Der Radiotherapie Des Pelvinen Lymphabflusses Beim Lokalisierten Prostatakarzinom Vom Hochrisikotyp Anhand Der Klinikdatenbank 2010-2016 Completed NCT02998619
11 Diagnostic Value of Radiographic Characteristics of Mediastinal and Hilar Lymph Nodes in Sarcoidosis Completed NCT04735302
12 Evolution of Indications for Transbronchial Ganglionic Ultrasound in the Picardie Region Over the Period 2008 - 2013 Completed NCT03132883
13 Identifying Ultrasonic Diagnostic Characteristics of Cervical Lymphadenopathy: A Retrospective, Multicenter Study Completed NCT04497714
14 Comparion of 22G-ProCore and 22G-Standard Needle in Diagnosis of Lymphadenopathy Via EBUS-TBNA: A Prospective, Single-center, Randomized Controlled Clinical Trial Recruiting NCT03903471
15 The Role of Micrometastasis and Isolated Tumor Cells (ITCs) in Uterine Cancers (Endometrial/Cervical) Submitted to Sentinel Lymph Nodes (SLN) Procedure: an Observational Study Recruiting NCT04403867
16 Performing a Lymphatic-venous Anastomosis at Time of Nodal Dissection in Patients Requiring Complete Axillary or Groin Dissection for the Prevention of Lymphedema Terminated NCT03073096

Search NIH Clinical Center for Lymph Node Disease

Genetic Tests for Lymph Node Disease

Anatomical Context for Lymph Node Disease

Organs/tissues related to Lymph Node Disease:

MalaCards : Lymph Node, Breast, Pancreas, Prostate, Thyroid, Lung, Bone Marrow

Publications for Lymph Node Disease

Articles related to Lymph Node Disease:

(show top 50) (show all 575)
# Title Authors PMID Year
1
Prophylactic Lymphaticovenous Anastomosis Performed with Lymphadenectomy is Oncologically Safe for Melanoma. 62
36471187 2022
2
Surgical Management of Melanoma: Advances and Updates. 62
35657482 2022
3
PEARLS - A multicentre phase II/III trial of extended field radiotherapy for androgen sensitive prostate cancer patients with PSMA-avid pelvic and/or para-aortic lymph nodes at presentation. 62
36238579 2022
4
Highly accurate response prediction in high-risk early breast cancer patients using a biophysical simulation platform. 62
36063220 2022
5
Robotic retroperitoneal lymph node dissection in colorectal cancer. 62
35765705 2022
6
Clinical indocyanine green-based silk fibroin theranostic nanoprobes for in vivo NIR-I/II fluorescence imaging of cervical diseases. 62
36265558 2022
7
Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer. 62
35842534 2022
8
ASO Author Reflections: Lymph Node Disease in Soft Tissue Sarcoma: A Problematic Clinical Dilemma. 62
35486264 2022
9
Point-of-care ultrasound in the head and neck region. 62
36284028 2022
10
Therapy and prognostic significance of regional lymph node involvement in embryonal rhabdomyosarcoma: a report from the European paediatric Soft tissue sarcoma Study Group. 62
35763871 2022
11
Wedge Resection vs Lobectomy for Clinical Stage IA Non-Small Cell Lung Cancer With Occult Lymph Node Disease. 62
36126718 2022
12
Prognostic utility of SOX2, STAT3, and CD44high/CD24low expression in penile cancer. 62
35913637 2022
13
Pretreatment visceral metastases in castration resistant metastatic prostate cancer: role in prediction versus actual site of disease progression. 62
35836271 2022
14
The Oncotype DX Recurrence Score's Impact on the Management of Oestrogen-Positive/Human Epidermal Growth Factor Receptor 2-Negative, Low-Burden Axillary Status Breast Cancer (REHAB Study): Results of a Single Centre. 62
36042999 2022
15
Radical vs. Local Excision in Rectal Carcinoma T1N0M0: Recurrence and Mortality Rates. 62
35663694 2022
16
Predictors of lymph node metastases in patients with malignant adenomatous polyps of the colon. 62
34340861 2022
17
The Diagnostic Performance of 18F-PSMA-1007 PET/CT in Prostate Cancer Patients with Early Recurrence after Definitive Therapy with a PSA <10 ng/ml. 62
35421900 2022
18
A comprehensive review of interventional ablation techniques for the management of thyroid nodules and metastatic lymph nodes. 62
34776258 2022
19
Artificial Intelligence in Head and Neck Imaging. 62
35339257 2022
20
Evaluation of Survival and Postoperative Radiation Among Patients with Advanced Medullary Thyroid Carcinoma: An Analysis of the National Cancer Database. 62
35067791 2022
21
aPROMISE: A Novel Automated PROMISE Platform to Standardize Evaluation of Tumor Burden in 18F-DCFPyL Images of Veterans with Prostate Cancer. 62
34049980 2022
22
Prognostic value of the nodal yield in elective neck dissections in patients with head and neck carcinomas. 62
33938992 2022
23
Predictive factors of non-sentinel lymph node disease in breast cancer patients with positive sentinel lymph node. 62
35123939 2022
24
Male Perineal Carcinoma: Experience in 4 Cases and Literature Review. 62
36046383 2022
25
Flow Cytometric DNA Ploidy Analysis in Haemato-Lymphoid Neoplasms: An Analysis of 132 Cases. 62
35975117 2022
26
Prognosis value of lymphovascular invasion in patients with invasive ductal breast carcinoma according to lymph node metastasis status. 62
35685958 2022
27
Pelvic lymph node dissection in high-risk prostate cancer. 62
33861538 2022
28
21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer. 62
34914339 2021
29
Immunoglobulin G4-related lymph node disease with an orbital mass mimicking Castleman disease: A case report. 62
35047610 2021
30
MRI in head and neck cancer following chemoradiotherapy: what is the optimal delay to demonstrate maximal response? 62
34009413 2021
31
Multiparametric MRI with in-bore targeted biopsy in the diagnostic pathway of prostate cancer: Data from a single institution experience. 62
33676850 2021
32
Regression is significantly associated with outcomes for patients with melanoma. 62
34120749 2021
33
Invasive Lobular Breast Cancer: Data to Support Surgical Decision Making. 62
34324111 2021
34
The prognostic value of digital rectal exam for the existence of advanced pathologic features after prostatectomy. 62
34297858 2021
35
COVID-19 vaccination mimicking lymph-node progression in a patient with melanoma: a case report. 62
34433198 2021
36
Interdigitating dendritic cell sarcoma of pleura, diagnostic challenges of a rare disease. 62
34567944 2021
37
Identifying High-Risk Tumors within AJCC Stage IB-III Melanomas Using a Seven-Marker Immunohistochemical Signature. 62
34200680 2021
38
Understanding the Clinical Impact of MUC5AC Expression on Pancreatic Ductal Adenocarcinoma. 62
34205412 2021
39
Axillary Pathologic Complete Response After Neoadjuvant Systemic Therapy by Breast Cancer Subtype in Patients With Initially Clinically Node-Positive Disease: A Systematic Review and Meta-analysis. 62
33881478 2021
40
Tuberculosis in the paediatric age group: a reflection on transmission. 62
34090637 2021
41
[Corrigendum] LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of IL‑6 and TNF‑α. 62
33882644 2021
42
External evaluation of the Briganti nomogram to predict lymph node metastases in intermediate-risk prostate cancer patients. 62
32583038 2021
43
Diagnostic Performance of Noninvasive Imaging for Assessment of Axillary Response After Neoadjuvant Systemic Therapy in Clinically Node-positive Breast Cancer: A Systematic Review and Meta-analysis. 62
33201095 2021
44
Stage IIIa Melanoma and Impact of Multiple Positive Lymph Nodes on Survival. 62
33316426 2021
45
Examination of factors associated with lymph node metastases in lung carcinoids: Results from a single institution retrospective cohort study. 62
33551175 2021
46
[Penile Cancer: A case for non-lymph node disease following a negative sentinel node exploration.] 62
33650543 2021
47
Residual lymph node disease and mortality following neoadjuvant chemoradiation and curative esophagectomy for distal esophageal adenocarcinoma. 62
36003158 2021
48
Utility of sonography for identifying metastatic cervical adenopathy in children with differentiated thyroid carcinoma at presentation. 62
33030586 2021
49
Axillary lymph node metastasis: Fine-needle aspiration biopsy sensitivity as a function of node size, percent replacement of lymph node by tumor and tumor deposit size. 62
32945140 2021
50
Response in breast vs axilla after neoadjuvant treatment and implications for nonoperative management of invasive breast cancer. 62
33393166 2021

Variations for Lymph Node Disease

ClinVar genetic disease variations for Lymph Node Disease:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NF1 NM_001042492.3(NF1):c.3457_3460del (p.Leu1153fs) DEL Pathogenic
185963 rs1321848637 GRCh37: 17:29559859-29559862
GRCh38: 17:31232841-31232844

Expression for Lymph Node Disease

Search GEO for disease gene expression data for Lymph Node Disease.

Pathways for Lymph Node Disease

Pathways related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.14 SDHD SDHC SDHB SDHA
2 11.84 TNF IL6 CD8A CD4
3
Show member pathways
11.77 SDHD SDHC SDHB SDHA
4
Show member pathways
11.65 SDHD SDHC SDHB SDHA
5 11.53 TNF CD8A CD4 CCR6
6
Show member pathways
11.44 IL6 CRP CD8A CD4
7 11.33 TNF IL6 CD8A CD4
8 11.11 TNF IL6 ICOSLG CRP
9 11.1 TNF IL6 CD4
10 10.82 CRP IL6 TNF
11
Show member pathways
10.19 TNF IL6
12
Show member pathways
10.1 SDHD SDHC SDHB SDHAF2 SDHA

GO Terms for Lymph Node Disease

Cellular components related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.23 SDHD SDHC SDHB SDHA

Biological processes related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proton motive force-driven mitochondrial ATP synthesis GO:0042776 9.86 SDHD SDHC SDHB SDHA
2 acute-phase response GO:0006953 9.8 SERPINA3 IL6 CRP
3 succinate metabolic process GO:0006105 9.67 SDHB SDHA
4 tricarboxylic acid cycle GO:0006099 9.65 SDHD SDHC SDHB SDHAF2 SDHA
5 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF
6 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.32 SDHD SDHC SDHB SDHAF2 SDHA

Molecular functions related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.56 SDHD SDHC SDHB SDHA
2 succinate dehydrogenase activity GO:0000104 9.46 SDHC SDHA
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.1 SDHD SDHB SDHA

Sources for Lymph Node Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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