Lymph Node Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LYM116 MIFTS: 42	Lymph Node Disease Categories: Immune diseases
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Aliases & Classifications for Lymph Node Disease

MalaCards integrated aliases for Lymph Node Disease:

Name: Lymph Node Disease ¹² ¹⁵

Disorder of Lymph Node ⁷⁰

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9942

NCIt ⁵⁰ C35346

SNOMED-CT ⁶⁷ 76616003

UMLS ⁷⁰ C0272394

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Summaries for Lymph Node Disease

MalaCards based summary : Lymph Node Disease, also known as disorder of lymph node, is related to persistent generalized lymphadenopathy and squamous cell carcinoma, head and neck, and has symptoms including axillary lymph node pain, inguinal lymph node pain and inguinal lymph node tenderness. An important gene associated with Lymph Node Disease is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are Allograft rejection and Prion disease. The drugs Cisplatin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include lymph node, prostate and pancreas, and related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Lymph Node Disease

Diseases related to Lymph Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 602)

#	Related Disease	Score	Top Affiliating Genes
1	persistent generalized lymphadenopathy	31.9	TMEM127 SERPINA3 SDHD SDHC SDHB SDHAF2
2	squamous cell carcinoma, head and neck	30.5	MMP3 MMP1 MIR145 EPCAM CCR6
3	superior limbic keratoconjunctivitis	10.6	MMP3 MMP1
4	coronary artery aneurysm	10.5	MMP3 MMP1
5	spastic entropion	10.5	MMP3 MMP1
6	sporadic pheochromocytoma/secreting paraganglioma	10.5	SDHD SDHB
7	cork-handlers' disease	10.5	CD8A CD4
8	necrotic uveal melanoma	10.5	CD8A CD4
9	tendinopathy	10.5	MMP3 MMP1
10	suppurative lymphadenitis	10.5	CRP CD4 CCR6
11	early yaws	10.5	CD8A CD4
12	plethora of newborn	10.5	SDHD SDHB
13	drug reaction with eosinophilia and systemic symptoms	10.5	TNF CRP
14	ventilation pneumonitis	10.5	CD8A CD4
15	polyclonal hypergammaglobulinemia	10.5	SERPINA3 CRP CD4
16	viral meningitis	10.5	MMP3 MMP1 CRP
17	mucormycosis	10.5	CRP CD4 CCR6
18	punctate inner choroidopathy	10.5	TNF IL10
19	pelvic organ prolapse	10.5	MMP3 MMP1 CCR6
20	panophthalmitis	10.5	CRP CD4
21	esophageal candidiasis	10.5	CD8A CD4 CCR6
22	igg4-related disease	10.5	ICOSLG CRP CCR6
23	papilledema	10.5	SERPINA3 CRP CD4
24	henoch-schoenlein purpura	10.5	SERPINA3 ICOSLG CRP
25	autonomic nervous system benign neoplasm	10.5	TMEM127 SDHD SDHB
26	bursitis	10.5	TNF MMP3 CRP
27	tropical endomyocardial fibrosis	10.5	TNF IL10
28	peripheral nervous system benign neoplasm	10.5	TMEM127 SDHD SDHB
29	autoimmune cholangitis	10.5	CD8A CD4 CCR6
30	bullous skin disease	10.5	ICOSLG CD4 CCR6
31	primary syphilis	10.5	CRP CD8A CD4
32	diffuse infiltrative lymphocytosis syndrome	10.5	CD8A CD4
33	toxic megacolon	10.5	TNF CRP CCR6
34	bone deterioration disease	10.5	TNF MMP3 MMP1
35	immunodeficiency with hyper-igm, type 3	10.5	ICOSLG CD8A CD4
36	aspiration pneumonitis	10.5	TNF SERPINA3 CRP
37	rheumatoid arthritis interstitial lung disease	10.5	TNF CRP CD4
38	secondary syphilis	10.5	CRP CD8A CD4
39	parotid disease	10.5	CRP CD8A CD4
40	pustulosis of palm and sole	10.5	TNF CRP CCR6
41	subcutaneous mycosis	10.5	IL10 CD4 CCR6
42	meningovascular neurosyphilis	10.5	TNF CRP CD4
43	spondyloarthropathy	10.5	TNF MMP3 IL10
44	opportunistic bacterial infectious disease	10.5	TNF CRP CD4
45	tendinitis	10.5	TNF MMP3 CRP
46	thrombocytopenic purpura, autoimmune	10.5	ICOSLG CD4 CCR6
47	nocardiosis	10.5	TNF CRP CD4
48	arachnoiditis	10.5	TNF CRP CD4
49	gastrointestinal tuberculosis	10.5	TNF CRP CD4
50	intestinal tuberculosis	10.5	TNF CRP CD4

Graphical network of the top 20 diseases related to Lymph Node Disease:

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Symptoms & Phenotypes for Lymph Node Disease

UMLS symptoms related to Lymph Node Disease:

axillary lymph node pain; inguinal lymph node pain; inguinal lymph node tenderness

MGI Mouse Phenotypes related to Lymph Node Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.93	CCR6 CD4 CD8A EPCAM IL10 ITPKC
2	homeostasis/metabolism	MP:0005376	9.8	CCR6 CD4 CRP EPCAM IL10 MMP1
3	immune system	MP:0005387	9.4	CCR6 CD4 CD8A CRP EPCAM IL10

Sources

Drugs & Therapeutics for Lymph Node Disease

Drugs for Lymph Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cisplatin

Approved

Phase 3

15663-27-1

84093 441203 2767

Synonyms:

(SP-4-1)-diamminedichloridoplatinum

(SP-4-1)-diamminedichloroplatinum

(SP-4-2)-diamminedichloridoplatinum

(SP-4-2)-diamminedichloroplatinum

Abiplatin

Biocisplatinum

Briplatin

CACP

Carboquone

CDDP

CHEBI:35852

CID441203

Cis Pt II

cis-[PtCl2(NH3)2]

cis-DDP

Cis-DDP

Cis-Diaminedichloroplatinum

cis-diamminedichloridoplatinum(II)

cis-Diamminedichloroplatinum

Cis-Diamminedichloroplatinum

cis-diamminedichloroplatinum(II)

cis-Dichlorodiammineplatinum(II)

Cismaplat

Cisplatin

Cisplatine

cisplatino

Cisplatino

Cisplatinum

Cisplatyl

Citoplationo

CPD0-1392

CPDC

CPDD

DB00515

DDP

DDPT

Diamminedichloroplatinum

EU-0100918

Lederplatin

nchembio773-comp1

Neoplatin

Peyrone's chloride

Peyrone's salt

Plastin

Platamine

Platiblastin

Platidiam

Platinex

Platinol

Platinol-AQ

Platinoxan

Platinum Ammine Chloride

Platinum Ammonium Chloride

Platinum Diamine Dichloride

Randa

trans-DDP

Trans-DDP

Trans-Diaminedichloroplatinum

trans-diamminedichloridoplatinum(II)

Trans-Diamminedichloroplatinum

Trans-Dichlorodiammine Platinum

Trans-Platinumdiammine Dichloride

Docetaxel

Approved, Investigational

Phase 3

114977-28-5

148124

Synonyms:

(2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate

01885_FLUKA

114977-28-5

4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate

AC1L3WHJ

AC-383

ANX-514

BIND-014

C11231

CHEBI:4672

CHEMBL92

CID148124

D07866

DB01248

docetaxel

Docetaxel

Docetaxel (INN)

docetaxel 114977-28-5

Docetaxel anhydrous

Docetaxel hydrate

Docetaxel trihydrate

Docetaxel, trihydrate

Docetaxel, Trihydrate

Docetaxol

EmDOC

HMS2089K08

InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,5

MolPort-003-847-005

N Debenzoyl N tert butoxycarbonyl 10 deacetyltaxol

nchembio.188-comp8

nchembio.2007.34-comp7

nchembio.573-comp11

nchembio853-comp8

N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel

N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel

N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

N-debenzoyl-N-Boc-10-deacetyl taxol

N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol

NSC-628503

PSMA-targeted docetaxel nanoparticle

RP-56976

SDP-014

Taxoltere metro

Taxotere

Taxotere (TN)

Taxotere(R)

TXL

XRP-6976L

Capecitabine

Approved, Investigational

Phase 3

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

154361-50-9

158798-73-3

5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine

5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

AC1L1U83

AC1Q4KU8

Ambap154361-50-9

C110904

C12650

C15H22FN3O6

CAPE

Capecitabin

capecitabina

Capecitabina

capecitabine

Capecitabine

CAPECITABINE

Capécitabine

Capecitabine (JAN/USAN/INN)

Capecitabine [USAN]

capecitabinum

Capecitabinum

Capecitibine

Capiibine

Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester

Caxeta

CHEBI:31348

CHEMBL1773

CID60953

D01223

DB01101

FT-0082472

HSDB 7656

LS-59070

MolPort-005-938-254

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

R340

R-340

RG-340

Ro 09-1978

Ro 09-1978/000

Ro-09-1978

Ro-09-1978/000

S1156_Selleck

UNII-6804DJ8Z9U

Xabine

Xeloda

Xeloda (TN)

Xeloda, Captabin, Capecitabine

ZINC03806413

Progesterone

Approved, Vet_approved

Phase 3

57-83-0

5994

Synonyms:

(S)-4-Pregnene-3,20-dione

(S)-Pregn-4-en-3,20-dione

(S)-Progesterone

.beta.-Progesterone

.delta.(sup4)-Pregnene-3,20-dione

.delta.4-Pregnene-3,20-dione

17.alpha.-Progesterone

17alpha-progesterone

17alpha-Progesterone

17a-Progesterone

17α-progesterone

17Α-progesterone

1dbb

1h60

257630-50-5

3,20-Pregnene-4

32104FB6-BF81-4F6E-83C2-024DEEAEB272

46665_FLUKA

46665_RIEDEL

4-Pregnen-3,20-dione

4-Pregnene-3,20-dione

57-83-0

753497-20-0

8012-32-6

8023-13-0

AC1L1LKF

AC-700

Agolutin

AI3-51682

Akrolutin

Amen

BB_NC-0185

beta-Progesterone

BHR-100

BIDD:ER0547

BIDD:PXR0094

Bio-luton

Bio-Luton

bmse000482

BPBio1_000676

BRD-K64994968-001-03-6

BSPBio_000614

C00410

CCRIS 533

CHEBI:17026

CHEMBL103

CID5994

CIDR

CMC_13406

COL-1620

Colprosterone

component of Cyclogesterin

Corlutin

Corlutina

Corluvite

Corporin

corpus luteum hormone

Corpus luteum hormone

Corpus Luteum Hormone

CPD000058345

Crinone

Crinone (TN)

Crinone progesterone gel

Curretab

Cyclogest

Cyclogesterin

Cycrin

D00066

D4-Pregnene-3,20-dione

DB00396

Delalutin

delta(4)-Pregnene-3,20-dione

Delta(4)-pregnene-3,20-dione

Delta(4)-Pregnene-3,20-dione

delta(sup 4)-Pregnene-3,20-dione

delta(Sup4)-pregnene-3,20-dione

delta4-Pregnene-3,20-dione

DR-2011

Duraprogen

EINECS 200-350-6

Endometrin

Estima

ETI-411

EU-0100895

FE-999913

Flavolutan

Fologenon

Gelbkoerperhormon

Gelbkörperhormon

Gesterol

Gesterol 100

Gesterol 50

Gestiron

Gestone

Gestormone

Gestron

Glanducorpin

Gynlutin

Gynoluton

Gynolutone

HMS1569O16

HMS2051O05

HMS2090J07

Hormoflaveine

Hormoluton

HSDB 3389

Hydroxyprogesterone caproate

Hydroxyprogesterone caproic acid

Lingusorbs

Lipolutin

Lipo-lutin

Lipo-Lutin

LMST02030159

Lopac0_000895

LS-234

Lucorteum

Lucorteum sol

Lucorteum Sol

Lugesteron

Luteal hormone

Luteal Hormone

Luteinique

Luteocrin normale

Luteocrin Normale

Luteodyn

Luteogan

luteohormone

Luteohormone

Luteol

Luteol (VAN)

Luteopur

Luteosan

Luteostab

Luteovis

Luteum

Lutex

Lutidon

Lutin

Lutinus

Lutociclina

Lutocuclin m

Lutocuclin M

Lutocyclin

Lutocyclin m

Lutocyclin M

Lutocylin

Lutocylol

Lutoform

Lutogyl

Lutogynon

Lutren

Lutromone

Membrettes

Methylpregnone

Micronized Progesterone

MLS000028517

MLS000758277

MLS001074187

MLS002222367

MolPort-001-794-643

MPA

Nalutron

Natural Progesterone

NCGC00022185-03

NCGC00022185-04

NCGC00022185-05

NCGC00022185-06

NCGC00022185-07

NCGC00022185-08

NCGC00022185-09

NCGC00090798-01

NCGC00090798-02

nchembio.2007.53-comp14

NCI60_042166

NSC 64377

NSC 9704

NSC64377

NSC9704

NSC-9704

P 0130

P0130_SIGMA

P0478

P3972_SIGMA

P6149_SIGMA

P7556_ALDRICH

P7556_SIGMA

P8783_SIGMA

P9776_SIGMA

Percutacrine

Percutacrine luteinique

Percutacrine Luteinique

Piaponon

Pranone

Pregn-4-en-3,20-dione

Pregn-4-ene-3,20-dione

Pregnene-3,20-dione

Pregnenedione

Prestwick_411

Prestwick0_000477

Prestwick1_000477

Prestwick2_000477

Prestwick3_000477

Primolut

Prochieve

Progeffik

Progekan

Progestan

Progestasert

Progesterol

Progesteron

Progesterona

Progesterona [INN-Spanish]

Progesterone

PROGESTERONE

Progestérone

Progesterone (JP15/USP/INN)

Progesterone [INN:BAN:JAN]

Progesterone [Progestins]

Progesterone, (13 alpha,17 alpha)-(+-)-isomer

Progesterone, (17 alpha)-isomer

Progesterone, (9 beta,10 alpha)-isomer

Progesterone, water-soluble

Progesterone: HBC complex

Progesterone-Water Soluble

Progesteronum

Progesteronum [INN-Latin]

Progestin

Progestogel

Progestol

Progeston

Progestone

Progestosol

Progestrel

Progestron

Progestronol

Projestaject

Prolets

Prolidon

Prolutin

Proluton

Prolutone

Prometrium

Prometrium (TN)

Prontogest

Protormone

S00293

S1705_Selleck

SAM001247039

SMR000058345

SMR000653542

SPBio_002553

Spectrum5_002053

SR-01000000088

SR-01000000088-5

Syngesterone

Syngestrets

Synovex S

Syntolutan

Thiuram E

Thiuranide

U 3672

UNII-4G7DS2Q64Y

Utrogest

Utrogestan

Vitarrine

WLN: L E5 B666 OV MUTJ A1 E1 FV1

ZINC04428529

Δ(4)-pregnene-3,20-dione

Tubulin Modulators

Phase 3

Antimitotic Agents

Phase 3

Estrogens

Phase 3

Antimetabolites

Phase 3

Ipilimumab

Approved

Phase 2

477202-00-9

nivolumab

Approved

Phase 2

946414-94-4

Antineoplastic Agents, Immunological

Phase 2

Antibodies

Phase 2

Immunoglobulins

Phase 2

Pancrelipase

Approved, Investigational

53608-75-6

Imidacloprid

Vet_approved

105827-78-9

86418

Synonyms:

(2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine

(e)-Imidacloprid

(Z)-Imidacloprid

1-((6-chloro-3-Pyridinyl)methyl)-N-nitro-2-imidazolidinimine

1-((6-Chloro-3-pyridinyl)methyl)-N-nitro-2-imidazolidinimine

1-((6-chloro-3-Pyridyl)methyl)-N-nitro-2-imidazolidinimine

1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine

1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine

1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9ci

Admire

Advantage

Advantage flea adulticide

Bayer brand OF imidacloprid

Confidor

Confidor 200 SL

Confidor SL

Gaucho

IMD

Imidacloprid (old RN)

Merit

Merit (insecticide)

Premise 75

Provado

pancreatin

Immunologic Factors

Antiviral Agents

Interferon alpha-2

Interferon-alpha

interferons

Anti-Infective Agents

Interventional clinical trials:

(show all 11)

#	Name	Status	NCT ID	Phase	Drugs
1	Definitive Chemo-Radiotherapy With or Without Up-front Neck Dissection for Regionally Advanced Head and Neck Squamous Cell Carcinoma: A Phase III Multi-center Prospective Randomized Controlled Trial With Two Additional Observational Cohorts	Recruiting	NCT02918955	Phase 3	Chemotherapy (Cisplatin)
2	A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy	Recruiting	NCT01901094	Phase 3
3	MINDACT (Microarray In Node-Negative and 1 to 3 Positive Lymph Node Disease May Avoid Chemotherapy): A Prospective, Randomized Study Comparing the 70-Gene Signature With the Common Clinical-Pathological Criteria in Selecting Patients for Adjuvant Chemotherapy in Breast Cancer With 0 to 3 Positive Nodes	Active, not recruiting	NCT00433589	Phase 3	anthracycline-based;docetaxel and capecitabine
4	Neoadjuvant Phase II Study of TLR9 Agonist CMP-001 in Combination With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease	Active, not recruiting	NCT03618641	Phase 2	CMP-001
5	Role of Color Doppler Ultrasound in Differentiation Between Benign and Malignant Lymphadenopathy	Unknown status	NCT03760094
6	Performing a Lymphatic-venous Anastomosis at Time of Nodal Dissection in Patients Requiring Complete Axillary or Groin Dissection for the Prevention of Lymphedema	Unknown status	NCT03073096
7	Comparion of 22G-ProCore and 22G-Standard Needle in Diagnosis of Lymphadenopathy Via EBUS-TBNA: A Prospective, Multicenter, Randomized Controlled Clinical Trial	Unknown status	NCT03903471
8	Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®) in Tumors of the Pancreas, Submucosal Tumors and Lymph Node Disease of the Upper GI Tract	Unknown status	NCT03621852
9	Pilot Study of IFN-alpha-2b Dose Reduction With Dose Optimization	Completed	NCT01460875
10	Identifying Ultrasonic Diagnostic Characteristics of Cervical Lymphadenopathy: A Retrospective, Multicenter Study	Completed	NCT04497714
11	Prediction Model Based on Deep Learning of CP-EBUS Multimodal Image in the Diagnosis of Benign and Malignant Lymph Nodes	Recruiting	NCT04328792

Search NIH Clinical Center for Lymph Node Disease

Sources

Genetic Tests for Lymph Node Disease

Sources

Anatomical Context for Lymph Node Disease

MalaCards organs/tissues related to Lymph Node Disease:

⁴⁰

Lymph Node, Prostate, Pancreas, Colon, Cervix, Bone Marrow, Lung

Sources

Publications for Lymph Node Disease

Articles related to Lymph Node Disease:

(show top 50) (show all 537)

#	Title	Authors	PMID	Year
1	Diagnostic Performance of Noninvasive Imaging for Assessment of Axillary Response After Neoadjuvant Systemic Therapy in Clinically Node-positive Breast Cancer: A Systematic Review and Meta-analysis. ⁶¹	Samiei S...Smidt ML	33201095	2021
2	Stage IIIa Melanoma and Impact of Multiple Positive Lymph Nodes on Survival. ⁶¹	Woeste MR...Egger ME	33316426	2021
3	[Penile Cancer: A case for non-lymph node disease following a negative sentinel node exploration.] ⁶¹	Lloret-Dura MA...Martinez-Jabaloyas JM	33650543	2021
4	Multiparametric MRI with in-bore targeted biopsy in the diagnostic pathway of prostate cancer: Data from a single institution experience. ⁶¹	Nawfal G...Sarkis P	33676850	2021
5	Response in breast vs axilla after neoadjuvant treatment and implications for nonoperative management of invasive breast cancer. ⁶¹	Schmidt H...Jaffer S	33393166	2021
6	Utility of sonography for identifying metastatic cervical adenopathy in children with differentiated thyroid carcinoma at presentation. ⁶¹	Navallas M...Wasserman J	33030586	2021
7	Axillary lymph node metastasis: Fine-needle aspiration biopsy sensitivity as a function of node size, percent replacement of lymph node by tumor and tumor deposit size. ⁶¹	Layfield LJ...Schmidt R	32945140	2021
8	Examination of factors associated with lymph node metastases in lung carcinoids: Results from a single institution retrospective cohort study. ⁶¹	Pathipati MP...Padda SK	33551175	2021
9	Should metastatic lymph nodes be considered at the same clinical stage as distant metastasis in soft tissue sarcomas? ⁶¹	Garcia-Ortega DY...Luna-Ortiz K	33340903	2021
10	Radiotherapy plus chemotherapy versus chemotherapy alone in penile cancer patients with extracapsular nodal extension after inguinal lymph node surgery: a multi-institutional study. ⁶¹	Li ZS...Zhou FJ	32303900	2021
11	Clinical Manifestations Associated with Bartonella henselae Infection in a Tropical Region. ⁶¹	Tay SY...Baird R	33021197	2021
12	Melanoma of Unknown Primary: Evaluation of the Characteristics, Treatment Strategies, Prognostic Factors in a Monocentric Retrospective Study. ⁶¹	Del Fiore P...Mocellin S	33747946	2021
13	Recent Evolution in the Management of Lymph Node Metastases in Melanoma. ⁶¹	Breit S...Mammen J	33763181	2021
14	Applicability of sentinel lymph node oriented treatment strategy for gallbladder cancer. ⁶¹	Yasukawa K...Soejima Y	33577620	2021
15	Inguinal lymph node dissection for penile cancer: a contemporary review. ⁶¹	Teh J...Lawrentschuk N	33457292	2020
16	Predictive factors of non-sentinel lymph node disease in breast cancer patients with positive sentinel lymph node. ⁶¹	Peyroteo M...de Sousa A	33358014	2020
17	High Mitotic Rate Predicts Sentinel Lymph Node Involvement in Thin Melanomas. ⁶¹	Skochdopole AJ...Camp ER	32711176	2020
18	[Tuberculosis in the paediatric age group: A reflection on transmission]. ⁶¹	Brandao Silva J...Carvalho I	33262096	2020
19	Long-Term Toxicity and Efficacy of Intensity-Modulated Radiation Therapy in Cervical Cancers: Experience of a Cancer Hospital in Pakistan. ⁶¹	Mansha MA...Chaudry SJ	33112682	2020
20	Regional Lymph Node Involvement Among Patients With De Novo Metastatic Breast Cancer. ⁶¹	Bitencourt A...Braunstein LZ	33034638	2020
21	[Clinic analysis of cervical lymph node lesions in children]. ⁶¹	Lou F...Zeng W	33254300	2020
22	Cost-effectiveness analysis of the 70-gene signature compared with clinical assessment in breast cancer based on a randomised controlled trial. ⁶¹	Retel VP...van Harten WH	32795875	2020
23	[Primary intraosseous Rosai-Dorfman disease: a clinicopathological analysis of fourteen cases]. ⁶¹	Dong RF...Ding Y	32892555	2020
24	How should we stage and tailor treatment strategy in locally advanced cervical cancer? Imaging versus para-aortic surgical staging. ⁶¹	Martinez A...Pomel C	32788263	2020
25	Can lymphadenectomy be omitted in advanced ovarian cancer?-a brief review. ⁶¹	Salcedo-Hernandez RA	32527112	2020
26	Impact of pathologic lymph node-positive renal cell carcinoma on survival in patients without metastasis: Evidence in support of expanding the definition of stage IV kidney cancer. ⁶¹	Srivastava A...Singer EA	32329899	2020
27	FDG-PET/CT scan assessment of response 12 weeks post radical radiotherapy in oropharynx head and neck cancer: The impact of p16 status. ⁶¹	Urban R...Hamilton S	32294581	2020
28	External evaluation of the Briganti nomogram to predict lymph node metastases in intermediate-risk prostate cancer patients. ⁶¹	Peilleron N...Fiard G	32583038	2020
29	Kikuchi disease as a possible cause of ischaemic stroke: a case report. ⁶¹	Liu L...Huang Q	32351150	2020
30	Performance of models predicting residual lymph node disease in melanoma patients following sentinel lymph node biopsy. ⁶¹	MacDonald S...Baliski C	32222274	2020
31	Is the involvement of the hepatic artery lymph node a poor prognostic factor in pancreatic adenocarcinoma? ⁶¹	Rodrigues V...Charco R	31839175	2020
32	Does hipec improve outcomes in gastric cancer patients treated with perioperative chemotherapy and radical surgery? A propensity-score matched analysis. ⁶¹	Diniz TP...Coimbra FJF	31950511	2020
33	Does small volume metastatic lymph node disease affect long-term prognosis in early cervical cancer? ⁶¹	Nica A...Covens A	31871114	2020
34	Performance of [68Ga] Ga-PSMA 11 PET for detecting prostate cancer in the lymph nodes before salvage lymph node dissection: a systematic review and meta-analysis. ⁶¹	Kimura S...Shariat SF	31147628	2020
35	A Large, Multicenter, Retrospective Study on Efficacy and Safety of Stereotactic Body Radiotherapy (SBRT) in Oligometastatic Ovarian Cancer (MITO RT1 Study): A Collaboration of MITO, AIRO GYN, and MaNGO Groups. ⁶¹	Macchia G...Ferrandina G	32043791	2020
36	Brachial plexus schwannoma mimicking advanced breast carcinoma. ⁶¹	da Costa Vieira RA...de Almeida Santos Yamashita ME	32083563	2020
37	FDG PET-CT in pediatric Langerhans cell histiocytosis. ⁶¹	Jessop S...Howman-Giles R	31599488	2020
38	Impact of the 8th edition of the AJCC TNM classification on gastric cancer prognosis-study of a western cohort. ⁶¹	Peyroteo M...de Sousa A	33209115	2020
39	Mummified Cells are a Common Finding in Cutaneous Hodgkin Lymphoma and Can Be Used as a Diagnostic Clue. ⁶¹	Kastnerova L...Kazakov DV	31169526	2020
40	Advances in axillary surgery for breast cancer 2019. ⁶¹	Sener SF	31240726	2020
41	Recurrent ilioinguinal lymph node metastasis from primary anal adenocarcinoma: what should we do?-A case report and review of literature. ⁶¹	Zhao Y...Wijaya R	32492641	2020
42	Primary Merkel Cell Carcinoma: The Clinical Experience of Taipei Veterans General Hospital Revisited. ⁶¹	Liao WC...Hsu CY	31833886	2020
43	Patterns of recurrence after prostate bed radiotherapy. ⁶¹	Brand DH...Parker C	31563410	2019
44	Preoperative Computed Tomography Changes Surgical Management for Clinically Low-Risk Well-Differentiated Thyroid Cancer. ⁶¹	Bongers PJ...Rotstein LE	31583547	2019
45	Impact of adjuvant chemotherapy regimen on survival outcomes in immunohistochemical subtypes of ampullary carcinoma. ⁶¹	Al Abbas AI...Zureikat AH	31840257	2019
46	Effectiveness of radiotherapy for head and neck skin cancers: a single-institution study. ⁶¹	Kim JW...Kim YS	31918468	2019
47	Stereotactic body radiotherapy for bone oligometastatic disease in prostate cancer. ⁶¹	Patel PH...van As NJ	31346760	2019
48	Radical Cystectomy in Female Patients - Improving Outcomes. ⁶¹	Kalampokis N...Gakis G	31781877	2019
49	A systematic review of the effectiveness of adjuvant therapy for patients with gallbladder cancer. ⁶¹	Manterola C...Garcia N	30922845	2019
50	Neuroendocrine Tumors of Meckel's Diverticula: Rare but Fare Well. ⁶¹	De Andrade JP...Singh G	31657307	2019

Sources

Genes for Lymph Node Disease

Genes related to Lymph Node Disease (0 elite genes):

(show all 41)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MMP3	Matrix Metallopeptidase 3	Protein Coding	11.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	11.2	DISEASES inferred ¹⁵ ¹⁵
3	MMP1	Matrix Metallopeptidase 1	Protein Coding	11.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	10.53	DISEASES inferred ¹⁵ ¹⁵
5	EPCAM	Epithelial Cell Adhesion Molecule	Protein Coding	10.46	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	SERPINA3	Serpin Family A Member 3	Protein Coding	9.85	DISEASES inferred ¹⁵ ¹⁵
7	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	8.49	DISEASES inferred ¹⁵
8	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	8.31	DISEASES inferred ¹⁵
9	CD4	CD4 Molecule	Protein Coding	8.1	DISEASES inferred ¹⁵
10	MIR483	MicroRNA 483	RNA Gene	8.07	DISEASES inferred ¹⁵ ¹⁵
11	CRP	C-Reactive Protein	Protein Coding	7.94	DISEASES inferred ¹⁵
12	ITPKC	Inositol-Trisphosphate 3-Kinase C	Protein Coding	7.92	DISEASES inferred ¹⁵
13	MIR145	MicroRNA 145	RNA Gene	7.87	DISEASES inferred ¹⁵ ¹⁵
14	TMEM127	Transmembrane Protein 127	Protein Coding	7.79	DISEASES inferred ¹⁵
15	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	7.65	DISEASES inferred ¹⁵
16	CD8A	CD8a Molecule	Protein Coding	7.62	DISEASES inferred ¹⁵
17	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	7.59	DISEASES inferred ¹⁵
18	TNF	Tumor Necrosis Factor	Protein Coding	7.54	DISEASES inferred ¹⁵
19	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	7.51	DISEASES inferred ¹⁵
20	IL10	Interleukin 10	Protein Coding	7.48	DISEASES inferred ¹⁵
21	MIR200B	MicroRNA 200b	RNA Gene	7.35	DISEASES inferred ¹⁵ ¹⁵
22	IL6	Interleukin 6	Protein Coding	7.33	DISEASES inferred ¹⁵
23	IL17A	Interleukin 17A	Protein Coding	7.18	DISEASES inferred ¹⁵
24	IL4	Interleukin 4	Protein Coding	7.13	DISEASES inferred ¹⁵
25	ALB	Albumin	Protein Coding	7.1	DISEASES inferred ¹⁵
26	IL1B	Interleukin 1 Beta	Protein Coding	7.07	DISEASES inferred ¹⁵
27	FOXP3	Forkhead Box P3	Protein Coding	6.98	DISEASES inferred ¹⁵
28	SIGLEC5	Sialic Acid Binding Ig Like Lectin 5	Protein Coding	6.95	DISEASES inferred ¹⁵ ¹⁵
29	IL2	Interleukin 2	Protein Coding	6.93	DISEASES inferred ¹⁵
30	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	6.92	DISEASES inferred ¹⁵
31	RET	Ret Proto-Oncogene	Protein Coding	6.9	DISEASES inferred ¹⁵
32	ITGAX	Integrin Subunit Alpha X	Protein Coding	6.85	DISEASES inferred ¹⁵
33	IFNG	Interferon Gamma	Protein Coding	6.8	DISEASES inferred ¹⁵
34	FCGR2A	Fc Fragment Of IgG Receptor IIa	Protein Coding	6.72	DISEASES inferred ¹⁵
35	ITGAE	Integrin Subunit Alpha E	Protein Coding	6.68	DISEASES inferred ¹⁵
36	MMP14	Matrix Metallopeptidase 14	Protein Coding	6.66	GeneCards inferred via : Publications (show sections)
37	TRIM21	Tripartite Motif Containing 21	Protein Coding	6.64	DISEASES inferred ¹⁵
38	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	6.63	DISEASES inferred ¹⁵
39	NF1	Neurofibromin 1	Protein Coding	6.58	DISEASES inferred ¹⁵
40	TLR2	Toll Like Receptor 2	Protein Coding	6.57	DISEASES inferred ¹⁵
41	CD40	CD40 Molecule	Protein Coding	6.56	DISEASES inferred ¹⁵

Sources

Variations for Lymph Node Disease

Sources

Expression for Lymph Node Disease

Search GEO for disease gene expression data for Lymph Node Disease.

Sources

Pathways for Lymph Node Disease

Pathways related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.66	TNF IL10 ICOSLG CD8A CD4
2	Prion disease ³⁶ Show member pathways Parkinson disease ³⁶	12.65	TNF SDHD SDHC SDHB SDHA
3	Carbon metabolism ³⁶ Show member pathways 2-Oxocarboxylic acid metabolism ³⁶ Biosynthesis of amino acids ³⁶ formaldehyde oxidation ¹	12.12	SDHD SDHC SDHB SDHA
4	Yersinia infection ³⁶	11.89	TNF IL10 CD8A CD4
5	Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁵ Show member pathways Citric acid cycle (TCA cycle) ⁶⁵ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁵ NAD phosphorylation and dephosphorylation ¹ Pyruvate metabolism ⁶⁵ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁵ TCA Cycle ¹	11.85	SDHD SDHC SDHB SDHA
6	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.77	TNF IL10 CD8A CD4
7	Interleukin-4 and 13 signaling ⁶⁵	11.73	TNF MMP3 MMP1 IL10
8	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.57	TNF IL10 CD4
9	Citrate cycle (TCA cycle) ³⁶ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.57	SDHD SDHC SDHB SDHA
10	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.45	TNF MMP3 MMP1
11	IgA-Producing B Cells in the Intestine ⁶⁴	11.28	TNF IL10 ICOSLG CCR6
12	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.26	TNF IL10 CD8A CD4 CCR6
13	Cytokines and Inflammatory Response ¹	10.96	TNF IL10 CD4
14	Dendritic Cells Developmental Lineage Pathway ⁶⁴	10.89	TNF IL10 EPCAM CD8A CD4

Sources

GO Terms for Lymph Node Disease

Cellular components related to Lymph Node Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.55	TNF ICOSLG CD8A CD4 CCR6
2	respiratory chain complex II	GO:0045273	8.96	SDHC SDHB
3	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.92	SDHD SDHC SDHB SDHA

Biological processes related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.88	TNF IL10 CD8A CD4 CCR6
2	electron transport chain	GO:0022900	9.69	SDHC SDHB SDHA
3	positive regulation of protein complex assembly	GO:0031334	9.58	TNF MMP3 MMP1
4	cytokine-mediated signaling pathway	GO:0019221	9.55	TNF MMP3 MMP1 IL10 CD4
5	cellular response to UV-A	GO:0071492	9.49	MMP3 MMP1
6	negative regulation of lipid storage	GO:0010888	9.46	TNF CRP
7	endothelial cell apoptotic process	GO:0072577	9.43	TNF IL10
8	T cell activation	GO:0042110	9.43	ICOSLG CD8A CD4
9	succinate metabolic process	GO:0006105	9.37	SDHB SDHA
10	tricarboxylic acid cycle	GO:0006099	9.35	SDHD SDHC SDHB SDHAF2 SDHA
11	negative regulation of cytokine production involved in immune response	GO:0002719	9.32	TNF IL10
12	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	8.92	SDHD SDHC SDHAF2 SDHA

Molecular functions related to Lymph Node Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ubiquinone binding	GO:0048039	9.26	SDHD SDHB
2	electron transfer activity	GO:0009055	9.26	SDHD SDHC SDHB SDHA
3	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.16	SDHB SDHA
4	succinate dehydrogenase activity	GO:0000104	8.8	SDHD SDHC SDHA

Sources

Sources for Lymph Node Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia