Lymph Node Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lymph Node Disease

MalaCards integrated aliases for Lymph Node Disease:

Name: Lymph Node Disease ¹¹ ¹⁴

Abnormality of the Lymph Nodes ⁵

Disorder of Lymph Node ⁷¹

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:9942

NCIt ⁴⁹ C35346

SNOMED-CT ⁶⁸ 76616003

UMLS ⁷¹ C0272394

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Summaries for Lymph Node Disease

MalaCards based summary: Lymph Node Disease, also known as abnormality of the lymph nodes, is related to persistent generalized lymphadenopathy and lymphadenitis, and has symptoms including axillary lymph node pain, inguinal lymph node pain and inguinal lymph node tenderness. An important gene associated with Lymph Node Disease is NF1 (Neurofibromin 1), and among its related pathways/superpathways are glycolysis (BioCyc) and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Letrozole and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and pancreas, and related phenotypes are homeostasis/metabolism and neoplasm

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Related Diseases for Lymph Node Disease

Diseases related to Lymph Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 961)

#	Related Disease	Score	Top Affiliating Genes
1	persistent generalized lymphadenopathy	32.1	TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
2	lymphadenitis	32.0	TNF SERPINA3 MIR223 ITPKC IL6 ICOSLG
3	meningitis	30.4	TNF IL6 CRP ALB
4	penile cancer	30.4	MIR223 CD8A CD4
5	castleman disease	30.4	IL6 H2AC18 CRP CD4 CCR6
6	bronchitis	30.3	TNF IL6 CRP ALB
7	kidney cancer	30.3	SDHB ICOSLG H2AC18 CCR6
8	lymphatic system disease	30.1	SERPINA3 MIR483 MIR223 ICOSLG H2AC18 CD8A
9	esophageal cancer	29.8	TNF MIR483 MIR223 IL6 ICOSLG H2AC18
10	histiocytosis	10.5	TNF SERPINA3 CCR6
11	sporadic pheochromocytoma/secreting paraganglioma	10.5	SDHD SDHB
12	purpura	10.5	TNF IL6 CRP
13	myelitis	10.5	TNF IL6 CCR6
14	hilar lung neoplasm	10.5	CD8A CD4
15	duodenal somatostatinoma	10.5	TMEM127 SDHAF2 NF1
16	leiomyoma cutis	10.5	SDHD SDHB SDHA
17	external pathological resorption	10.5	TNF IL6
18	dermis tumor	10.5	SDHD SDHB SDHA
19	paragangliomas 4	10.5	SDHD SDHB
20	foster-kennedy syndrome	10.5	SDHD SDHAF2 SDHA
21	enterocolitis	10.5	TNF IL6 CRP
22	scrotum melanoma	10.5	SDHD SDHA
23	cystitis	10.5	TNF IL6 CRP
24	carotid body cancer	10.5	SDHD SDHB
25	glomus tumor	10.5	SDHD SDHB NF1
26	orbital disease	10.5	NF1 CRP CD4
27	syphilitic meningitis	10.5	CRP CD4
28	thyroiditis	10.5	TNF IL6 CRP
29	multiple mucosal neuroma	10.5	TMEM127 NF1
30	atypical depressive disorder	10.5	SERPINA3 IL6 CRP
31	sapho syndrome	10.5	TNF CRP CCR6
32	horner's syndrome	10.5	SDHD SDHB NF1 CRP
33	chronic duodenal ileus	10.5	CRP ALB
34	enthesopathy	10.4	TNF CRP CCR6
35	peripheral nerve schwannoma	10.4	SERPINA3 NF1
36	ventilation pneumonitis	10.4	CRP CD8A CD4
37	multiple endocrine neoplasia	10.4	SDHD SDHC SDHB NF1
38	pollen allergy	10.4	ICOSLG CD4 CCR6
39	gastric liposarcoma	10.4	SDHD SDHB SDHA NF1
40	oral tuberculosis	10.4	CD8A CD4
41	legume allergy	10.4	ICOSLG CD4 CCR6
42	fruit allergy	10.4	ICOSLG CD4 CCR6
43	pericardial tuberculosis	10.4	TNF CRP CD4
44	early yaws	10.4	CD8A CD4
45	hydrops of gallbladder	10.4	ITPKC CRP ALB
46	chronic pyelonephritis	10.4	SERPINA3 CRP ALB
47	spongiotic dermatitis	10.4	CD8A CD4 CCR6
48	optic papillitis	10.4	TNF CRP CD4
49	suppurative lymphadenitis	10.4	CRP CD8A CD4
50	impetigo	10.4	SERPINA3 IL6 CCR6

Graphical network of the top 20 diseases related to Lymph Node Disease:

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Symptoms & Phenotypes for Lymph Node Disease

UMLS symptoms related to Lymph Node Disease:

axillary lymph node pain; inguinal lymph node pain; inguinal lymph node tenderness

MGI Mouse Phenotypes related to Lymph Node Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10	ALB CCR6 CD4 CRP ICOSLG IL6
2	neoplasm	MP:0002006	9.8	ALB IL6 NF1 SDHB SDHC SDHD
3	immune system	MP:0005387	9.8	ALB CCR6 CD4 CD8A CRP ICOSLG
4	hematopoietic system	MP:0005397	9.47	CCR6 CD4 CD8A ICOSLG IL6 ITPKC

Sources

Drugs & Therapeutics for Lymph Node Disease

Drugs for Lymph Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Letrozole

Approved, Investigational

Phase 3

112809-51-5

3902

2

Capecitabine

Approved, Investigational

Phase 3

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

Capecitabin

Capecitabina

CAPECITABINE

Capécitabine

Capecitabinum

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

PENTYL [1-(3,4-DIHYDROXY-5-METHYL-OXOLAN-2-YL)-5-FLUORO-2-OXO-PYRIMIDIN-4-YL]AMINOFORMATE

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

R340

RO-091978000

RO-09-1978000

RO-09-1978-000

Ro-09-1978-000|Ro-091978000|Xeloda®

Xeloda

3

Tamoxifen

Approved

Phase 3

10540-29-1, 54965-24-1

2733526

4

Progesterone

Approved, Vet_approved

Phase 3

57-83-0

5994

Synonyms:

(1S,2R,10S,11S,14S,15S)-14-ACETYL-2,15-DIMETHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADEC-6-EN-5-ONE

(8S,9S,10R,13S,14S,17S)-17-ACETYL-10,13-DIMETHYL-1,2,6,7,8,9,11,12,14,15,16,17-DODECAHYDROCYCLOPENTA[A]PHENANTHREN-3-ONE

(8S,9S,10R,13S,14S,17S)-17-ETHANOYL-10,13-DIMETHYL-1,2,6,7,8,9,11,12,14,15,16,17-DODECAHYDROCYCLOPENTA[A]PHENANTHREN-3-ONE

(S)-4-PREGNENE-3,20-DIONE

(S)-PREGN-4-EN-3,20-DIONE

(S)-PROGESTERONE

17ALPHA-PROGESTERONE

17A-PROGESTERONE

17Α-PROGESTERONE

3,20-PREGNENE-4

4-PREGNEN-3,20-DIONE

4-PREGNENE-3,20-DIONE

AGOLUTIN

AKROLUTIN

Amen

BETA-PROGESTERONE

BIO-LUTON

CIDR

COLPROSTERONE

CORLUTIN

CORLUTINA

CORLUVITE

CORPORIN

CORPUS LUTEUM HORMONE

CRINONE

CRINONE PROGESTERONE GEL

CURRETAB

CYCLOGEST

CYCLOGESTERIN

Cycrin

D4-PREGNENE-3,20-DIONE

DELALUTIN

DELTA(4)-PREGNENE-3,20-DIONE

DELTA(SUP 4)-PREGNENE-3,20-DIONE

DURAPROGEN

ENDOMETRIN

ESTIMA

FLAVOLUTAN

FOLOGENON

Gelbkoerperhormon

GELBKÖRPERHORMON

GESTEROL

GESTEROL 100

GESTEROL 50

GESTIRON

GESTONE

GESTORMONE

GESTRON

GLANDUCORPIN

GYNLUTIN

GYNOLUTON

GYNOLUTONE

HORMOFLAVEINE

HORMOLUTON

Hydroxyprogesterone caproate

Hydroxyprogesterone caproic acid

LINGUSORBS

LIPO-LUTIN

LUCORTEUM

LUCORTEUM SOL

LUGESTERON

LUTEAL HORMONE

Luteinique

LUTEOCRIN NORMALE

LUTEODYN

LUTEOGAN

LUTEOHORMONE

LUTEOL

LUTEOPUR

LUTEOSAN

LUTEOSTAB

LUTEOVIS

LUTEUM

LUTEX

LUTIDON

LUTIGEST

Lutin

LUTOCICLINA

LUTOCUCLIN M

LUTOCYCLIN

LUTOCYCLIN M

LUTOCYLIN

LUTOCYLOL

LUTOFORM

LUTOGYL

LUTOGYNON

LUTREN

LUTROMONE

MEMBRETTES

METHYLPREGNONE

MPA

NALUTRON

NSC-64377

NSC-9704

PERCUTACRINE

PERCUTACRINE LUTEINIQUE

PIAPONON

PRANONE

PREGN-4-EN-3,20-DIONE

PREGN-4-ENE-3,20-DIONE

PREGNENE-3,20-DIONE

PREGNENEDIONE

PRIMOLUT

PROCHIEVE

PROGEFFIK

PROGEKAN

PROGESTA-CARE

PROGESTAN

PROGESTASERT

PROGESTEROL

PROGESTERON

PROGESTERONA

Progesterona [INN-Spanish]

PROGESTERONE

PROGESTÉRONE

Progesterone, (13 alpha,17 alpha)-(+-)-isomer

Progesterone, (17 alpha)-isomer

Progesterone, (9 beta,10 alpha)-isomer

PROGESTERONUM

Progesteronum [INN-Latin]

PROGESTIN

PROGESTOGEL

PROGESTOL

PROGESTON

PROGESTONE

PROGESTOSOL

PROGESTRON

PROGESTRONOL

PROJESTAJECT

PROLETS

PROLIDON

PROLUTIN

PROLUTON

PROLUTONE

PROMETRIUM

Prometrium®|Utrogestan®

PRONTOGEST

PROTORMONE

REGUMATE

SERENITY FOR WOMEN

SYNGESTERONE

SYNGESTRETS

SYNGESTRONE

SYNOVEX S

SYNTOLUTAN

Thiuram E

Thiuranide

U 3672

UTROGEST

UTROGESTAN

VITARRINE

Δ(4)-pregnene-3,20-dione

5

Docetaxel

Approved, Investigational

Phase 3

114977-28-5

148124

6

Antineoplastic Agents, Hormonal

Phase 3

7

Estrogens

Phase 3

8

Estrogen Receptor Modulators

Phase 3

9

Estrogen Receptor Antagonists

Phase 3

10

Estrogen Antagonists

Phase 3

11

Hormones

Phase 3

12

Antimitotic Agents

Phase 3

13

Antimetabolites

Phase 3

14

Hormone Antagonists

Phase 3

15

Tubulin Modulators

Phase 3

16

Aromatase Inhibitors

Phase 3

17

Selective Estrogen Receptor Modulators

Phase 3

18

Nivolumab

Approved

Phase 2

946414-94-4

19

Ipilimumab

Approved

Phase 2

477202-00-9

20

Immunoglobulins

Phase 2

21

Immune Checkpoint Inhibitors

Phase 2

22

Antibodies

Phase 2

23

Antineoplastic Agents, Immunological

Phase 2

24

Pancrelipase

Approved, Investigational

53608-75-6

8519

25

Imidacloprid

Vet_approved

105827-78-9

86418

26

Pancreatin

Interventional clinical trials:

(show all 16)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomised Clinical Trial of Surgery Versus Surgery Plus Adjuvant Radiotherapy for Regional Control in Patients With Completely Resected Macroscopic Nodal Metastatic Melanoma	Completed	NCT00287196	Phase 3
2	MINDACT (Microarray In Node-Negative and 1 to 3 Positive Lymph Node Disease May Avoid Chemotherapy): A Prospective, Randomized Study Comparing the 70-Gene Signature With the Common Clinical-Pathological Criteria in Selecting Patients for Adjuvant Chemotherapy in Breast Cancer With 0 to 3 Positive Nodes	Completed	NCT00433589	Phase 3	anthracycline-based;docetaxel and capecitabine;tamoxifen;Letrozole
3	A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy	Active, not recruiting	NCT01901094	Phase 3
4	Neoadjuvant Phase II Study of TLR9 Agonist CMP-001 in Combination With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease	Active, not recruiting	NCT03618641	Phase 2	CMP-001
5	Investigating the Feasibility of Fluorescence Targeted Pelvic Lymph Node Mapping During Rectal Cancer Surgery	Terminated	NCT03204994	Phase 1, Phase 2	Indocyanine Green
6	Role of Color Doppler Ultrasound in Differentiation Between Benign and Malignant Lymphadenopathy	Unknown status	NCT03760094
7	Prediction Model Based on Deep Learning of CP-EBUS Multimodal Image in the Diagnosis of Benign and Malignant Lymph Nodes	Unknown status	NCT04328792
8	Prospective Analysis of the Survival of Patients With a Reduction in the Number of Lymph Nodes in Rectal Cancer After Neoadjuvant Chemoradiotherapy	Unknown status	NCT04456283
9	Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®) in Tumors of the Pancreas, Submucosal Tumors and Lymph Node Disease of the Upper GI Tract	Unknown status	NCT03621852
10	Retrospektive Analyse Der Radiotherapie Des Pelvinen Lymphabflusses Beim Lokalisierten Prostatakarzinom Vom Hochrisikotyp Anhand Der Klinikdatenbank 2010-2016	Completed	NCT02998619
11	Diagnostic Value of Radiographic Characteristics of Mediastinal and Hilar Lymph Nodes in Sarcoidosis	Completed	NCT04735302
12	Evolution of Indications for Transbronchial Ganglionic Ultrasound in the Picardie Region Over the Period 2008 - 2013	Completed	NCT03132883
13	Identifying Ultrasonic Diagnostic Characteristics of Cervical Lymphadenopathy: A Retrospective, Multicenter Study	Completed	NCT04497714
14	Comparion of 22G-ProCore and 22G-Standard Needle in Diagnosis of Lymphadenopathy Via EBUS-TBNA: A Prospective, Single-center, Randomized Controlled Clinical Trial	Recruiting	NCT03903471
15	The Role of Micrometastasis and Isolated Tumor Cells (ITCs) in Uterine Cancers (Endometrial/Cervical) Submitted to Sentinel Lymph Nodes (SLN) Procedure: an Observational Study	Recruiting	NCT04403867
16	Performing a Lymphatic-venous Anastomosis at Time of Nodal Dissection in Patients Requiring Complete Axillary or Groin Dissection for the Prevention of Lymphedema	Terminated	NCT03073096

Search NIH Clinical Center for Lymph Node Disease

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Genetic Tests for Lymph Node Disease

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Anatomical Context for Lymph Node Disease

Organs/tissues related to Lymph Node Disease:

MalaCards : Lymph Node, Breast, Pancreas, Prostate, Thyroid, Lung, Bone Marrow

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Publications for Lymph Node Disease

Articles related to Lymph Node Disease:

(show top 50) (show all 575)

#	Title	Authors	PMID	Year
1	Prophylactic Lymphaticovenous Anastomosis Performed with Lymphadenectomy is Oncologically Safe for Melanoma. ⁶²	Xia TY...Gastman BR	36471187	2022
2	Surgical Management of Melanoma: Advances and Updates. ⁶²	Santamaria-Barria JA...Mammen JMV	35657482	2022
3	PEARLS - A multicentre phase II/III trial of extended field radiotherapy for androgen sensitive prostate cancer patients with PSMA-avid pelvic and/or para-aortic lymph nodes at presentation. ⁶²	Murray J...PEARLS Trial Management Group	36238579	2022
4	Highly accurate response prediction in high-risk early breast cancer patients using a biophysical simulation platform. ⁶²	Howard FM...Nanda R	36063220	2022
5	Robotic retroperitoneal lymph node dissection in colorectal cancer. ⁶²	Othman B...Warrier S	35765705	2022
6	Clinical indocyanine green-based silk fibroin theranostic nanoprobes for in vivo NIR-I/II fluorescence imaging of cervical diseases. ⁶²	Ma R...Ma C	36265558	2022
7	Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer. ⁶²	Orozco JIJ...DiNome ML	35842534	2022
8	ASO Author Reflections: Lymph Node Disease in Soft Tissue Sarcoma: A Problematic Clinical Dilemma. ⁶²	Witt RG...Keung EZ	35486264	2022
9	Point-of-care ultrasound in the head and neck region. ⁶²	Furukawa M...Yoshida M	36284028	2022
10	Therapy and prognostic significance of regional lymph node involvement in embryonal rhabdomyosarcoma: a report from the European paediatric Soft tissue sarcoma Study Group. ⁶²	Ben-Arush M...Bisogno G	35763871	2022
11	Wedge Resection vs Lobectomy for Clinical Stage IA Non-Small Cell Lung Cancer With Occult Lymph Node Disease. ⁶²	Kneuertz PJ...Merritt RE	36126718	2022
12	Prognostic utility of SOX2, STAT3, and CD44high/CD24low expression in penile cancer. ⁶²	de Barros FD...Guimaraes GC	35913637	2022
13	Pretreatment visceral metastases in castration resistant metastatic prostate cancer: role in prediction versus actual site of disease progression. ⁶²	Ruchalski K...Goldin J	35836271	2022
14	The Oncotype DX Recurrence Score's Impact on the Management of Oestrogen-Positive/Human Epidermal Growth Factor Receptor 2-Negative, Low-Burden Axillary Status Breast Cancer (REHAB Study): Results of a Single Centre. ⁶²	Saad Abdalla Al-Zawi A...Aladili Z	36042999	2022
15	Radical vs. Local Excision in Rectal Carcinoma T1N0M0: Recurrence and Mortality Rates. ⁶²	Khalid A...Chouhan H	35663694	2022
16	Predictors of lymph node metastases in patients with malignant adenomatous polyps of the colon. ⁶²	Artinyan A...Nasseri Y	34340861	2022
17	The Diagnostic Performance of 18F-PSMA-1007 PET/CT in Prostate Cancer Patients with Early Recurrence after Definitive Therapy with a PSA <10 ng/ml. ⁶²	Lengana T...Sathekge MM	35421900	2022
18	A comprehensive review of interventional ablation techniques for the management of thyroid nodules and metastatic lymph nodes. ⁶²	Kuo JH...Baek JH	34776258	2022
19	Artificial Intelligence in Head and Neck Imaging. ⁶²	Pham N...Mukherji SK	35339257	2022
20	Evaluation of Survival and Postoperative Radiation Among Patients with Advanced Medullary Thyroid Carcinoma: An Analysis of the National Cancer Database. ⁶²	Ow TJ...In H	35067791	2022
21	aPROMISE: A Novel Automated PROMISE Platform to Standardize Evaluation of Tumor Burden in 18F-DCFPyL Images of Veterans with Prostate Cancer. ⁶²	Nickols N...Rettig M	34049980	2022
22	Prognostic value of the nodal yield in elective neck dissections in patients with head and neck carcinomas. ⁶²	Leon X...Quer M	33938992	2022
23	Predictive factors of non-sentinel lymph node disease in breast cancer patients with positive sentinel lymph node. ⁶²	Peyroteo M...de Sousa A	35123939	2022
24	Male Perineal Carcinoma: Experience in 4 Cases and Literature Review. ⁶²	Poblador AF...Revilla JB	36046383	2022
25	Flow Cytometric DNA Ploidy Analysis in Haemato-Lymphoid Neoplasms: An Analysis of 132 Cases. ⁶²	Gupta N...Handoo A	35975117	2022
26	Prognosis value of lymphovascular invasion in patients with invasive ductal breast carcinoma according to lymph node metastasis status. ⁶²	da Luz FAC...Silva MJB	35685958	2022
27	Pelvic lymph node dissection in high-risk prostate cancer. ⁶²	Haiquel L...Secin F	33861538	2022
28	21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer. ⁶²	Kalinsky K...Hortobagyi GN	34914339	2021
29	Immunoglobulin G4-related lymph node disease with an orbital mass mimicking Castleman disease: A case report. ⁶²	Hao FY...Zhao X	35047610	2021
30	MRI in head and neck cancer following chemoradiotherapy: what is the optimal delay to demonstrate maximal response? ⁶²	Connor SEJ...Goh V	34009413	2021
31	Multiparametric MRI with in-bore targeted biopsy in the diagnostic pathway of prostate cancer: Data from a single institution experience. ⁶²	Nawfal G...Sarkis P	33676850	2021
32	Regression is significantly associated with outcomes for patients with melanoma. ⁶²	Subramanian S...Han D	34120749	2021
33	Invasive Lobular Breast Cancer: Data to Support Surgical Decision Making. ⁶²	Cocco D...Valente SA	34324111	2021
34	The prognostic value of digital rectal exam for the existence of advanced pathologic features after prostatectomy. ⁶²	Prebay ZJ...Johnson SC	34297858	2021
35	COVID-19 vaccination mimicking lymph-node progression in a patient with melanoma: a case report. ⁶²	Indini A...Grossi F	34433198	2021
36	Interdigitating dendritic cell sarcoma of pleura, diagnostic challenges of a rare disease. ⁶²	Gupta N...Agarwal R	34567944	2021
37	Identifying High-Risk Tumors within AJCC Stage IB-III Melanomas Using a Seven-Marker Immunohistochemical Signature. ⁶²	Reschke R...Ziemer M	34200680	2021
38	Understanding the Clinical Impact of MUC5AC Expression on Pancreatic Ductal Adenocarcinoma. ⁶²	Manne A...Tsung A	34205412	2021
39	Axillary Pathologic Complete Response After Neoadjuvant Systemic Therapy by Breast Cancer Subtype in Patients With Initially Clinically Node-Positive Disease: A Systematic Review and Meta-analysis. ⁶²	Samiei S...EUBREAST Group	33881478	2021
40	Tuberculosis in the paediatric age group: a reflection on transmission. ⁶²	Silva JB...Carvalho I	34090637	2021
41	[Corrigendum] LYPD8 regulates the proliferation and migration of colorectal cancer cells through inhibiting the secretion of IL‑6 and TNF‑α. ⁶²	Xu J...Song Z	33882644	2021
42	External evaluation of the Briganti nomogram to predict lymph node metastases in intermediate-risk prostate cancer patients. ⁶²	Peilleron N...Fiard G	32583038	2021
43	Diagnostic Performance of Noninvasive Imaging for Assessment of Axillary Response After Neoadjuvant Systemic Therapy in Clinically Node-positive Breast Cancer: A Systematic Review and Meta-analysis. ⁶²	Samiei S...Smidt ML	33201095	2021
44	Stage IIIa Melanoma and Impact of Multiple Positive Lymph Nodes on Survival. ⁶²	Woeste MR...Egger ME	33316426	2021
45	Examination of factors associated with lymph node metastases in lung carcinoids: Results from a single institution retrospective cohort study. ⁶²	Pathipati MP...Padda SK	33551175	2021
46	[Penile Cancer: A case for non-lymph node disease following a negative sentinel node exploration.] ⁶²	Lloret-Dura MA...Martinez-Jabaloyas JM	33650543	2021
47	Residual lymph node disease and mortality following neoadjuvant chemoradiation and curative esophagectomy for distal esophageal adenocarcinoma. ⁶²	Kandilis A...Wee JO	36003158	2021
48	Utility of sonography for identifying metastatic cervical adenopathy in children with differentiated thyroid carcinoma at presentation. ⁶²	Navallas M...Wasserman J	33030586	2021
49	Axillary lymph node metastasis: Fine-needle aspiration biopsy sensitivity as a function of node size, percent replacement of lymph node by tumor and tumor deposit size. ⁶²	Layfield LJ...Schmidt R	32945140	2021
50	Response in breast vs axilla after neoadjuvant treatment and implications for nonoperative management of invasive breast cancer. ⁶²	Schmidt H...Jaffer S	33393166	2021

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Genes for Lymph Node Disease

Genes related to Lymph Node Disease (1 elite genes):

(show all 43)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NF1	Neurofibromin 1	Protein Coding	406.67	Pathogenic ⁵ DISEASES inferred ¹⁴
2	SERPINA3	Serpin Family A Member 3	Protein Coding	9.04	DISEASES inferred ¹⁴ ¹⁴
3	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	8.72	DISEASES inferred ¹⁴ ¹⁴
4	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	8.5	DISEASES inferred ¹⁴
5	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	8.2	DISEASES inferred ¹⁴
6	CRP	C-Reactive Protein	Protein Coding	8.2	DISEASES inferred ¹⁴
7	MIR483	MicroRNA 483	RNA Gene	8.08	DISEASES inferred ¹⁴ ¹⁴
8	ITPKC	Inositol-Trisphosphate 3-Kinase C	Protein Coding	7.94	DISEASES inferred ¹⁴
9	TMEM127	Transmembrane Protein 127	Protein Coding	7.92	DISEASES inferred ¹⁴
10	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	7.72	DISEASES inferred ¹⁴ ¹⁴
11	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	7.71	DISEASES inferred ¹⁴
12	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	7.58	DISEASES inferred ¹⁴
13	CD4	CD4 Molecule	Protein Coding	7.56	DISEASES inferred ¹⁴
14	MIR223	MicroRNA 223	RNA Gene	7.47	DISEASES inferred ¹⁴ ¹⁴
15	IL6	Interleukin 6	Protein Coding	7.44	DISEASES inferred ¹⁴
16	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	7.41	DISEASES inferred ¹⁴
17	TNF	Tumor Necrosis Factor	Protein Coding	7.31	DISEASES inferred ¹⁴
18	CD8A	CD8a Molecule	Protein Coding	7.23	DISEASES inferred ¹⁴
19	H2AC18	H2A Clustered Histone 18	Protein Coding	7.1	DISEASES inferred ¹⁴ ¹⁴
20	ALB	Albumin	Protein Coding	7.02	DISEASES inferred ¹⁴
21	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	7.02	DISEASES inferred ¹⁴
22	IL1B	Interleukin 1 Beta	Protein Coding	7	DISEASES inferred ¹⁴
23	MIR145	MicroRNA 145	RNA Gene	7	DISEASES inferred ¹⁴ ¹⁴
24	IL10	Interleukin 10	Protein Coding	6.98	DISEASES inferred ¹⁴
25	RET	Ret Proto-Oncogene	Protein Coding	6.92	DISEASES inferred ¹⁴
26	MIR150	MicroRNA 150	RNA Gene	6.82	DISEASES inferred ¹⁴ ¹⁴
27	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	6.74	DISEASES inferred ¹⁴
28	IFNG	Interferon Gamma	Protein Coding	6.74	DISEASES inferred ¹⁴
29	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	6.58	DISEASES inferred ¹⁴
30	IL17A	Interleukin 17A	Protein Coding	6.56	DISEASES inferred ¹⁴
31	IL18	Interleukin 18	Protein Coding	6.54	DISEASES inferred ¹⁴
32	IL2	Interleukin 2	Protein Coding	6.54	DISEASES inferred ¹⁴
33	EPAS1	Endothelial PAS Domain Protein 1	Protein Coding	6.52	DISEASES inferred ¹⁴
34	MEFV	MEFV Innate Immunity Regulator, Pyrin	Protein Coding	6.51	DISEASES inferred ¹⁴
35	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	6.49	DISEASES inferred ¹⁴
36	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	6.43	DISEASES inferred ¹⁴
37	S100A12	S100 Calcium Binding Protein A12	Protein Coding	6.41	DISEASES inferred ¹⁴
38	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	6.4	DISEASES inferred ¹⁴
39	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6.4	DISEASES inferred ¹⁴
40	NPPB	Natriuretic Peptide B	Protein Coding	6.36	DISEASES inferred ¹⁴
41	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	6.35	DISEASES inferred ¹⁴
42	CD68	CD68 Molecule	Protein Coding	6.28	DISEASES inferred ¹⁴
43	THRIL	TNF And HNRNPL Related Immunoregulatory Long Non-Coding RNA	RNA Gene	6.26	DISEASES inferred ¹⁴

Sources

Variations for Lymph Node Disease

ClinVar genetic disease variations for Lymph Node Disease:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	NF1	NM_001042492.3(NF1):c.3457_3460del (p.Leu1153fs)	DEL	Pathogenic	185963	rs1321848637	GRCh37: 17:29559859-29559862 GRCh38: 17:31232841-31232844

Sources

Expression for Lymph Node Disease

Search GEO for disease gene expression data for Lymph Node Disease.

Sources

Pathways for Lymph Node Disease

Pathways related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	glycolysis (BioCyc) ⁶¹ Show member pathways Aerobic glycolysis ⁷⁴ glycolysis ⁶¹ Glycolysis and gluconeogenesis ⁷⁴ Glycolysis and gluconeogenesis (short map) ²² glycolysis III (from glucose) ⁶¹ homolactic fermentation ⁶¹ Manipulation of host energy metabolism ⁶⁶	12.14	SDHD SDHC SDHB SDHA
2	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.84	TNF IL6 CD8A CD4
3	Pyruvate metabolism ⁶⁶ Show member pathways Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁶ pyruvate decarboxylation to acetyl CoA ⁶¹ Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁶ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁶	11.77	SDHD SDHC SDHB SDHA
4	TCA cycle III (animals) ⁶¹ Show member pathways Citric acid cycle (TCA cycle) ⁶⁶ TCA cycle ⁶¹ TCA cycle (aka Krebs or citric acid cycle) ⁷⁴ TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc) ⁷⁴	11.65	SDHD SDHC SDHB SDHA
5	Innate Lymphoid Cells Differentiation ⁶⁵	11.53	TNF CD8A CD4 CCR6
6	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.44	IL6 CRP CD8A CD4
7	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.33	TNF IL6 CD8A CD4
8	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.11	TNF IL6 ICOSLG CRP
9	Cytokines and inflammatory response ⁷⁴	11.1	TNF IL6 CD4
10	Overview of nanoparticle effects ⁷⁴	10.82	CRP IL6 TNF
11	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.19	TNF IL6
12	Mitochondrial complex II assembly ⁷⁴ Show member pathways aerobic respiration I (cytochrome c) ⁶¹	10.1	SDHD SDHC SDHB SDHAF2 SDHA

Sources

GO Terms for Lymph Node Disease

Cellular components related to Lymph Node Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	9.23	SDHD SDHC SDHB SDHA

Biological processes related to Lymph Node Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	proton motive force-driven mitochondrial ATP synthesis	GO:0042776	9.86	SDHD SDHC SDHB SDHA
2	acute-phase response	GO:0006953	9.8	SERPINA3 IL6 CRP
3	succinate metabolic process	GO:0006105	9.67	SDHB SDHA
4	tricarboxylic acid cycle	GO:0006099	9.65	SDHD SDHC SDHB SDHAF2 SDHA
5	negative regulation of lipid storage	GO:0010888	9.63	CRP IL6 TNF
6	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	9.32	SDHD SDHC SDHB SDHAF2 SDHA

Molecular functions related to Lymph Node Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	electron transfer activity	GO:0009055	9.56	SDHD SDHC SDHB SDHA
2	succinate dehydrogenase activity	GO:0000104	9.46	SDHC SDHA
3	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.1	SDHD SDHB SDHA

Sources

Sources for Lymph Node Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LYM116 MIFTS: 43	Lymph Node Disease Categories: Immune diseases	Data Licensing For inquiries, contact: [email protected]
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