Lymph Node Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Lymph Node Disease

MalaCards integrated aliases for Lymph Node Disease:

Name: Lymph Node Disease ¹² ¹⁵

Disorder of Lymph Node ⁷³

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9942

NCIt ⁵⁰ C35346

SNOMED-CT ⁶⁸ 76616003

UMLS ⁷³ C0272394

Sources

Summaries for Lymph Node Disease

MalaCards based summary : Lymph Node Disease, also known as disorder of lymph node, is related to persistent generalized lymphadenopathy and superior limbic keratoconjunctivitis, and has symptoms including axillary lymph node pain, inguinal lymph node pain and inguinal lymph node tenderness. An important gene associated with Lymph Node Disease is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Colorectal Cancer Metastasis. The drugs Cisplatin and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and thyroid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Sources

Related Diseases for Lymph Node Disease

Diseases related to Lymph Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)

#	Related Disease	Score	Top Affiliating Genes
1	persistent generalized lymphadenopathy	29.3	CD40LG CD79A SDHA SDHAF2 SDHB SDHC
2	superior limbic keratoconjunctivitis	11.1	MMP1 MMP3
3	spastic entropion	10.9	MMP1 MMP3
4	paragangliomas 1	10.7	SDHB SDHC SDHD
5	chondroma	10.7	SDHB SDHC SDHD
6	paraganglioma and gastric stromal sarcoma	10.7	SDHB SDHC SDHD
7	sporadic pheochromocytoma	10.7	SDHB SDHC SDHD
8	borderline leprosy	10.7	CD40LG SDHD
9	selective igg deficiency disease	10.6	CD40LG CD79A
10	neurofibromatosis, type iv, of riccardi	10.6	SDHB SDHC SDHD
11	c1q nephropathy	10.6	CD40LG CD79A
12	multiple cranial nerve palsy	10.6	CD40LG CRP MMP3
13	von hippel-lindau syndrome	10.6	SDHB SDHC SDHD
14	meningovascular neurosyphilis	10.6	CD40LG CD79A
15	alpha chain disease	10.6	CD40LG CD79A
16	brill-zinsser disease	10.6	CD40LG CD79A
17	exudative glomerulonephritis	10.6	CD40LG CD79A
18	cork-handlers' disease	10.6	CD40LG CD79A
19	cowden disease	10.6	SDHB SDHC SDHD
20	salpingo-oophoritis	10.5	CD40LG CD79A
21	early yaws	10.5	CD40LG CD79A
22	ventilation pneumonitis	10.5	CD40LG CD79A
23	chronic interstitial cystitis	10.5	CD40LG CD79A
24	axillary adenitis	10.5	CD40LG CD79A
25	cryofibrinogenemia	10.5	CD40LG CD79A
26	acalculous cholecystitis	10.5	CD40LG CRP
27	cold agglutinin disease	10.5	CRP IL6
28	rheumatoid lung disease	10.5	CD40LG MMP3 TNF
29	trichostrongyloidiasis	10.5	CD40LG CD79A
30	subacute bacterial endocarditis	10.5	CD40LG CD79A
31	heterophyiasis	10.5	CD40LG CD79A
32	immunoglobulin g deficiency	10.5	CD40LG CD79A
33	orbital granuloma	10.4	CD40LG CD79A
34	transient hypogammaglobulinemia of infancy	10.4	CD40LG CD79A
35	carotid stenosis	10.4	CRP MMP1 TNF
36	scorpion envenomation	10.4	IL6 TNF
37	intestinal tuberculosis	10.4	CD79A CRP
38	hyperglobulinemic purpura	10.4	CD40LG CD79A
39	fibrosarcoma	10.4	MMP1 MMP14 MMP3 TNF
40	gastroduodenitis	10.4	CD40LG CD79A
41	periodontitis, chronic	10.4	IL6 MMP1
42	bacterial conjunctivitis	10.4	CD40LG CD79A
43	heavy chain disease	10.4	CD40LG CD79A
44	adrenal medulla cancer	10.4	SDHAF2 SDHB SDHC SDHD
45	extra-adrenal pheochromocytoma	10.4	SDHAF2 SDHB SDHC SDHD
46	mononeuritis multiplex	10.3	CD40LG CRP
47	streptococcal meningitis	10.3	CD40LG CRP TNF
48	scrub typhus	10.3	CD40LG CRP TNF
49	ophthalmia neonatorum	10.3	CD40LG CD79A
50	leukomalacia	10.3	IL6 TNF

Graphical network of the top 20 diseases related to Lymph Node Disease:

Sources

Symptoms & Phenotypes for Lymph Node Disease

UMLS symptoms related to Lymph Node Disease:

axillary lymph node pain, inguinal lymph node pain, inguinal lymph node tenderness

MGI Mouse Phenotypes related to Lymph Node Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.97	SDHB SDHC SDHD TMEM127 TNF CD40LG
2	homeostasis/metabolism	MP:0005376	9.8	CD40LG CD79A CRP EPCAM IL6 MMP1
3	immune system	MP:0005387	9.4	TMEM127 TNF CD40LG CD79A CRP EPCAM

Sources

Drugs & Therapeutics for Lymph Node Disease

Drugs for Lymph Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cisplatin

Approved

Phase 3

15663-27-1

84093 441203 2767

Synonyms:

(SP-4-1)-diamminedichloridoplatinum

(SP-4-1)-diamminedichloroplatinum

(SP-4-2)-diamminedichloridoplatinum

(SP-4-2)-diamminedichloroplatinum

Abiplatin

Biocisplatinum

Briplatin

CACP

Carboquone

CDDP

CHEBI:35852

CID441203

Cis Pt II

cis-[PtCl2(NH3)2]

cis-DDP

Cis-DDP

Cis-Diaminedichloroplatinum

cis-diamminedichloridoplatinum(II)

cis-Diamminedichloroplatinum

Cis-Diamminedichloroplatinum

cis-diamminedichloroplatinum(II)

cis-Dichlorodiammineplatinum(II)

Cismaplat

Cisplatine

Cisplatino

Cisplatinum

Cisplatyl

Citoplationo

CPD0-1392

CPDC

CPDD

DB00515

DDP

DDPT

Diamminedichloroplatinum

EU-0100918

Lederplatin

nchembio773-comp1

Neoplatin

Peyrone's chloride

Peyrone's salt

Plastin

Platamine

Platiblastin

Platidiam

Platinex

Platinol

Platinol-AQ

Platinoxan

Platinum Ammine Chloride

Platinum Ammonium Chloride

Platinum Diamine Dichloride

Randa

trans-DDP

Trans-DDP

Trans-Diaminedichloroplatinum

trans-diamminedichloridoplatinum(II)

Trans-Diamminedichloroplatinum

Trans-Dichlorodiammine Platinum

Trans-Platinumdiammine Dichloride

2

Capecitabine

Approved, Investigational

Phase 3

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

154361-50-9

158798-73-3

5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine

5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

AC1L1U83

AC1Q4KU8

Ambap154361-50-9

C110904

C12650

C15H22FN3O6

CAPE

Capecitabin

capecitabina

Capecitabina

capecitabine

CAPECITABINE

Capecitabine (JAN/USAN/INN)

Capecitabine [USAN]

capecitabinum

Capecitabinum

Capecitibine

Capiibine

Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester

Caxeta

CHEBI:31348

CHEMBL1773

CID60953

D01223

DB01101

FT-0082472

HSDB 7656

LS-59070

MolPort-005-938-254

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

R340

R-340

RG-340

Ro 09-1978

Ro 09-1978/000

Ro-09-1978

Ro-09-1978/000

S1156_Selleck

UNII-6804DJ8Z9U

Xabine

Xeloda

Xeloda (TN)

Xeloda, Captabin, Capecitabine

ZINC03806413

3

Progesterone

Approved, Vet_approved

Phase 3

57-83-0

5994

Synonyms:

(S)-4-Pregnene-3,20-dione

(S)-Pregn-4-en-3,20-dione

(S)-Progesterone

.beta.-Progesterone

.delta.(sup4)-Pregnene-3,20-dione

.delta.4-Pregnene-3,20-dione

17.alpha.-Progesterone

17alpha-progesterone

17alpha-Progesterone

17a-Progesterone

17α-progesterone

1dbb

1h60

257630-50-5

3,20-Pregnene-4

32104FB6-BF81-4F6E-83C2-024DEEAEB272

46665_FLUKA

46665_RIEDEL

4-Pregnen-3,20-dione

4-Pregnene-3,20-dione

57-83-0

753497-20-0

8012-32-6

8023-13-0

AC1L1LKF

AC-700

Agolutin

AI3-51682

Akrolutin

BB_NC-0185

beta-Progesterone

BHR-100

BIDD:ER0547

BIDD:PXR0094

bio-Luton

Bio-luton

bmse000482

BPBio1_000676

BRD-K64994968-001-03-6

BSPBio_000614

C00410

CCRIS 533

CHEBI:17026

CHEMBL103

CID5994

CIDR

CMC_13406

COL-1620

Colprosterone

component of Cyclogesterin

Corlutin

Corlutina

Corluvite

Corporin

corpus luteum hormone

Corpus luteum hormone

Corpus Luteum Hormone

CPD000058345

Crinone

Crinone (TN)

Crinone progesterone gel

Curretab

Cyclogest

Cyclogesterin

D00066

D4-Pregnene-3,20-dione

DB00396

Delalutin

delta(4)-Pregnene-3,20-dione

Delta(4)-pregnene-3,20-dione

Delta(4)-Pregnene-3,20-dione

delta(sup 4)-Pregnene-3,20-dione

delta(Sup4)-pregnene-3,20-dione

delta4-Pregnene-3,20-dione

DR-2011

Duraprogen

EINECS 200-350-6

Endometrin

Estima

ETI-411

EU-0100895

FE-999913

Flavolutan

Fologenon

Gelbkoerperhormon

Gelbkörperhormon

Gesterol

Gesterol 100

Gesterol 50

Gestiron

Gestone

Gestormone

Gestron

Glanducorpin

Gynlutin

Gynoluton

Gynolutone

HMS1569O16

HMS2051O05

HMS2090J07

Hormoflaveine

Hormoluton

HSDB 3389

Hydroxyprogesterone caproate

Hydroxyprogesterone caproic acid

Lingusorbs

lipo-Lutin

Lipolutin

Lipo-Lutin

LMST02030159

Lopac0_000895

LS-234

Lucorteum

Lucorteum sol

Lucorteum Sol

Lugesteron

Luteal hormone

Luteinique

Luteocrin normale

Luteodyn

Luteogan

luteohormone

Luteohormone

Luteol

Luteol (VAN)

Luteopur

Luteosan

Luteostab

Luteovis

Luteum

Lutex

Lutidon

Lutin

Lutinus

Lutociclina

Lutocuclin m

Lutocuclin M

Lutocyclin

Lutocyclin m

Lutocyclin M

Lutocylin

Lutocylol

Lutoform

Lutogyl

Lutogynon

Lutren

Lutromone

Membrettes

Methylpregnone

Micronized Progesterone

MLS000028517

MLS000758277

MLS001074187

MLS002222367

MolPort-001-794-643

MPA

Nalutron

Natural Progesterone

NCGC00022185-03

NCGC00022185-04

NCGC00022185-05

NCGC00022185-06

NCGC00022185-07

NCGC00022185-08

NCGC00022185-09

NCGC00090798-01

NCGC00090798-02

nchembio.2007.53-comp14

NCI60_042166

NSC 64377

NSC 9704

NSC64377

NSC9704

NSC-9704

P 0130

P0130_SIGMA

P0478

P3972_SIGMA

P6149_SIGMA

P7556_ALDRICH

P7556_SIGMA

P8783_SIGMA

P9776_SIGMA

Percutacrine

Percutacrine luteinique

Percutacrine Luteinique

Piaponon

Pranone

Pregn-4-en-3,20-dione

Pregn-4-ene-3,20-dione

Pregnene-3,20-dione

Pregnenedione

Prestwick_411

Prestwick0_000477

Prestwick1_000477

Prestwick2_000477

Prestwick3_000477

Primolut

Prochieve

Progeffik

Progekan

Progestan

Progestasert

Progesterol

Progesteron

Progesterona

Progesterona [INN-Spanish]

Progesterone

PROGESTERONE

Progestérone

Progesterone (JP15/USP/INN)

Progesterone [INN:BAN:JAN]

Progesterone [Progestins]

Progesterone, (13 alpha,17 alpha)-(+-)-isomer

Progesterone, (17 alpha)-isomer

Progesterone, (9 beta,10 alpha)-isomer

Progesterone, water-soluble

Progesterone: HBC complex

Progesterone-Water Soluble

Progesteronum

Progesteronum [INN-Latin]

Progestin

Progestogel

Progestol

Progeston

Progestone

Progestosol

Progestrel

Progestron

Progestronol

Projestaject

Prolets

Prolidon

Prolutin

Proluton

Prolutone

Prometrium

Prometrium (TN)

Prontogest

Protormone

S00293

S1705_Selleck

SAM001247039

SMR000058345

SMR000653542

SPBio_002553

Spectrum5_002053

SR-01000000088

SR-01000000088-5

Syngesterone

Syngestrets

Synovex S

Syntolutan

U 3672

UNII-4G7DS2Q64Y

Utrogest

Utrogestan

Vitarrine

WLN: L E5 B666 OV MUTJ A1 E1 FV1

ZINC04428529

δ(4)-pregnene-3,20-dione

4

Docetaxel

Approved, Investigational

Phase 3,Phase 2

114977-28-5

148124

Synonyms:

(2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate

01885_FLUKA

114977-28-5

4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate

AC1L3WHJ

AC-383

ANX-514

BIND-014

C11231

CHEBI:4672

CHEMBL92

CID148124

D07866

DB01248

docetaxel

Docetaxel

Docetaxel (INN)

docetaxel 114977-28-5

Docetaxel anhydrous

Docetaxel hydrate

Docetaxel trihydrate

Docetaxel, trihydrate

Docetaxel, Trihydrate

Docetaxol

EmDOC

HMS2089K08

InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,5

MolPort-003-847-005

nchembio.188-comp8

nchembio.2007.34-comp7

nchembio.573-comp11

nchembio853-comp8

N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel

N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel

N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

N-debenzoyl-N-Boc-10-deacetyl taxol

N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol

NSC-628503

PSMA-targeted docetaxel nanoparticle

RP-56976

SDP-014

Taxoltere metro

Taxotere

Taxotere (TN)

Taxotere(R)

TXL

XRP-6976L

5

Estrogens

Phase 3

6

Antimetabolites

Phase 3

7

Antimetabolites, Antineoplastic

Phase 3

8

Antimitotic Agents

Phase 3,Phase 2

9

Romidepsin

Approved, Investigational

Phase 2

128517-07-7

5352062

Synonyms:

(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentone

(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone

(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone

128517-07-7

AC1NS1N3

Antibiotic FR 901228

C087123

C24H36N4O6S2

CHEBI:61080

CHEMBL343448

Chromadax

Chromadax (TN)

chromodax

CID5352062

Cyclo((2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl), cyclic (3?5)-disulfide"

D06637

FK 228

FK228

FK-228

FK-901228

FR 901228

FR901228

FR-901228

HDInhib_000006

Istodax

LS-161318

L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide

nchembio.313-comp2

NSC 630176

NSC630176

NSC-630176

Probes1_000153

Probes2_000337

Romidepsin

Romidepsin (USAN)

10

Doxorubicin

Approved, Investigational

Phase 2

23214-92-8

31703

Synonyms:

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-a-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

111266-55-8

14-hydroxydaunomycin

14-Hydroxydaunomycin

14-hydroxydaunorubicine

14-Hydroxydaunorubicine

23214-92-8

23257-17-2

24385-08-8

25311-50-6

25316-40-9

25316-40-9 (hydrochloride)

29042-30-6

AC1L1M5T

AC1Q29OJ

adiblastine (hydrochloride salt)

ADM

ADR

adr iablatina (hydrochloride salt)

Adriablastin

Adriablastine

adriablastine (hydrochloride salt)

adriablatina (hydrochloride salt)

Adriacin (hydrochloride salt)

Adriamycin

Adriamycin PFS

Adriamycin PFS (hydrochloride salt)

Adriamycin RDF

Adriamycin RDF (hydrochloride salt)

Adriamycin semiquinone

Adriamycin Semiquinone

Adriblas tina

Adriblastin

Adriblastina

Adriblastina (hydrochloride salt)

Adriblastina (TN)

Adriblastine

adriblatina (hydrochloride salt)

Adrimedac

Aerosolized Doxorubicin

Baxter brand OF doxorubicin hydrochloride

Bedford brand OF doxorubicin hydrochloride

BPBio1_000502

BRD-K92093830-003-04-3

Bristol-myers squibb brand OF doxorubicin hydrochloride

BSPBio_000456

BSPBio_001031

C01661

C27H29NO11

Caelyx

CCRIS 739

Cell pharm brand OF doxorubicin hydrochloride

CHEBI:28748

CHEMBL179

CID31703

Columbia brand OF doxorubicin hydrochloride

Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74

Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120

D03899

DB00997

DM2

Doxil

Doxo

doxo Cell

doxo-Cell

Doxolem

doxorubicin

Doxorubicin

Doxorubicin (USAN/INN)

Doxorubicin [USAN:INN:BAN]

Doxorubicin citrate

Doxorubicin HCl

Doxorubicin hexal

Doxorubicin hydrochloride

Doxorubicin Hydrochloride

Doxorubicin hydrochloride (hydrochloride salt)

Doxorubicin NC

Doxorubicina

Doxorubicina [INN-Spanish]

Doxorubicina ferrer farm

Doxorubicina funk

Doxorubicina tedec

Doxorubicine

Doxorubicine [INN-French]

Doxorubicine baxter

Doxorubicin-hLL1

Doxorubicin-hLL1 conjugate

Doxorubicin-P4/D10

Doxorubicin-P4/D10 conjugate

Doxorubicinum

Doxorubicinum [INN-Latin]

Doxotec

DOX-SL

EINECS 245-495-6

Elan brand OF doxorubicin hydrochloride

Farmablastina (hydrochloride salt)

Farmiblastina

Ferrer brand OF doxorubicin hydrochloride

FI 106

Hexal brand OF doxorubicin hydrochloride

HMS2089H06

HSDB 3070

Hydrochloride, doxorubicin

Hydroxydaunomycin hydrochlor ide (hydrochloride salt)

Hydroxydaunomycin hydrochloride (hydrochloride salt)

Hydroxydaunorubicin

Hydroxydaunorubicin hydrochloride (hydrochloride salt)

JT9100000

Kenfarma brand OF doxorubicin hydrochloride

Lemery brand OF doxorubicin hydrochloride

LMPK13050001

LS-1029

LS-165655

Medac brand OF doxorubicin hydrochloride

MLS000759533

Myocet

NChemBio.2007.10-comp13

nchembio809-comp5

NCI-C01514

NDC 38242-874

Neocorp brand OF doxorubicin hydrochloride

NIOSH/JT9100000

NSC 123127

Onkodox

Onkoworks brand OF doxorubicin hydrochloride

Pfizer brand OF doxorubicin hydrochloride

Prasfarma brand OF doxorubicin hydrochloride

Prestwick0_000438

Prestwick1_000438

Prestwick2_000438

Prestwick3_000438

Probes1_000151

Probes2_000129

RDF Rubex

Resmycin

Ribodoxo

Ribosepharm brand OF doxorubicin hydrochloride

Rubex

Rubex (hydrochloride salt)

SMP1_000106

SPBio_002395

Tedec meiji brand OF doxorubicin hydrochloride

ThermoDox

TLC D-99

Triferric doxorubicin

UNII-80168379AG

Urokit doxo cell

Urokit doxo-cell

11

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Synonyms:

(-)-Cyclophosphamide

(+-)-Cyclophosphamide

(RS)-Cyclophosphamide

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

4-Hydroxy-cyclophosphan-mamophosphatide

50-18-0

60007-95-6

6055-19-2 (monohydrate)

75526-90-8

AC1L1EQQ

AI3-26198

Anhydrous cyclophosphamide

Anhydrous, cyclophosphamide

ASTA

Asta B 518

ASTA B518

B 518

B-518

bis(2-Chloroethyl)phosphami de cyclic propanolamide

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

BRN 0011744

BSPBio_002099

C 0768

C07888

C7H15Cl2N2O2P

CB 4564

CB-4564

CCRIS 188

CHEBI:4027

CHEMBL32520

CHEMBL88

Ciclofosfamida

Ciclofosfamida [INN-Spanish]

Ciclofosfamide

Ciclophosphamide

Ciclophosphamide [INN]

CID2907

Clafen

Claphene

CP

CPA

CTX

CY

Cycloblastin

Cyclophosphamid

cyclophosphamide

Cyclophosphamide

Cyclophosphamide (anhydrous form)

Cyclophosphamide (anhydrous)

Cyclophosphamide (INN)

Cyclophosphamide (TN)

Cyclophosphamide anhydrous

Cyclophosphamide monohydrate

Cyclophosphamide Monohydrate

Cyclophosphamide Sterile

Cyclophosphamide, (+-)-Isomer

Cyclophosphamide, (R)-isomer

Cyclophosphamide, (S)-isomer

Cyclophosphamides

Cyclophosphamidum

Cyclophosphamidum [INN-Latin]

Cyclophosphan

Cyclophosphane

Cyclophosphanum

Cyclophosphoramide

Cyclostin

Cyklofosfamid

Cyklofosfamid [Czech]

Cytophosphan

Cytophosphane

Cytoxan

Cytoxan (TN)

Cytoxan Lyoph

D,L-Cyclophosphamide

D07760

DB00531

DivK1c_000246

EINECS 200-015-4

Endoxan

Endoxan R

Endoxana

Endoxanal

Endoxan-Asta

Endoxane

Enduxan

EU-0100238

Genoxal

Hexadrin

HMS2090A12

HSDB 3047

IDI1_000246

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

KBioGR_000888

KBioSS_001338

Ledoxina

Lopac0_000238

Lopac-C-0768

LS-1302

LS-99787

Lyophilized Cytoxan

Mitoxan

MolPort-001-783-420

Monohydrate, cyclophosphamide

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

NCGC00015209-01

NCGC00015209-03

NCGC00015209-06

NCGC00091741-02

NCGC00091741-03

NCI60_002097

NCI-C04900

Neosar

NINDS_000246

NSC 26271

NSC26271

NSC-26271

NSC273033

NSC273034

Occupation, cyclophosphamide exposure

Procytox

RCRA waste no. U058

Rcra waste number U058

Rcra Waste Number U058

Revimmune

S1217_Selleck

Semdoxan

Sendoxan

Senduxan

SK 20501

SPBio_001071

Spectrum_000858

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

STK177249

STOCK2S-91217

UNII-6UXW23996M

WLN: T6MPOTJ BO BN2G2G

Zyklophosphamid

Zyklophosphamid [German]

12

Doxil

Approved June 1999

Phase 2

31703

13

Anti-Bacterial Agents

Phase 2

14

Antibiotics, Antitubercular

Phase 2

15

Alkylating Agents

Phase 2

16

Topoisomerase Inhibitors

Phase 2

17

Immunosuppressive Agents

Phase 2

18

Antirheumatic Agents

Phase 2

19

Antineoplastic Agents, Alkylating

Phase 2

20

Inosine pranobex

Approved

Not Applicable

36703-88-5

21

interferons

Not Applicable

22

Anti-Infective Agents

Not Applicable

23

Interferon-alpha

Not Applicable

24

Antiviral Agents

Not Applicable

25

Adjuvants, Immunologic

Not Applicable

Interventional clinical trials:

(show all 18)

#	Name	Status	NCT ID	Phase	Drugs
1	Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes	Completed	NCT00287196	Phase 3
2	Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy	Recruiting	NCT01901094	Phase 3
3	Definitive Chemo-Radiotherapy for Regionally Advanced Head and Neck Cancer With or Without Up-front Neck Dissection	Recruiting	NCT02918955	Phase 3	Chemotherapy (Cisplatin)
4	Genetic Testing or Clinical Assessment in Determining the Need for Chemotherapy in Women With Breast Cancer That Involves No More Than 3 Lymph Nodes	Active, not recruiting	NCT00433589	Phase 3	anthracycline-based;docetaxel and capecitabine
5	Depsipeptide to Treat Patients With Cutaneous T-Cell Lymphoma and Peripheral T-Cell Lymphoma	Completed	NCT00007345	Phase 2	Romidepsin
6	Fluorescence Targeted Pelvic Lymph Node Mapping	Enrolling by invitation	NCT03204994	Phase 1, Phase 2	Indocyanine Green
7	Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in Early Stage Breast Cancer	Terminated	NCT00636441	Phase 2	Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC)
8	Recombinant Interferon Alfa-2b in Treating Patients With Melanoma	Unknown status	NCT01460875	Not Applicable
9	Bronchoscopic Sampling Techniques in Sarcoidosis	Unknown status	NCT01836822	Not Applicable
10	A Study of Isoprinosine in Patients With Lymph Node Disease	Completed	NCT00002297	Not Applicable	Inosine pranobex
11	The Safety and Effectiveness of Isoprinosine in Patients With Weakened Immune Systems and Lymph Node Disease	Completed	NCT00002296	Not Applicable	Inosine pranobex
12	CT Detection of Metastatic Lymphadenopathy in Papillary Thyroid Cancer	Completed	NCT03359668	Not Applicable
13	LYMPHA: Eliminating the Burden of Lymphedema in Patients Requiring Nodal Dissection	Recruiting	NCT03073096	Not Applicable
14	Radiotherapy of Pelvic Lymph Nodes in High Risk Prostate Cancer - A Retrospective Analysis	Recruiting	NCT02998619
15	MR-guided RAdiotherapy to Breast With Dose Escalation to regionaL Lymph NodEs	Recruiting	NCT03405519	Not Applicable
16	Unlock the Cell: Castleman's Disease Flow Cytometry Study	Recruiting	NCT02853968
17	Evolution of Indications for Transbronchial Ganglionic Ultrasound in the Picardie Region Over the Period 2008 - 2013	Not yet recruiting	NCT03132883
18	Dynamic Contrast Enhanced Computed Tomography (CT) for Head and Neck Cancer	Terminated	NCT01549379	Not Applicable

Search NIH Clinical Center for Lymph Node Disease

Sources

Genetic Tests for Lymph Node Disease

Sources

Anatomical Context for Lymph Node Disease

MalaCards organs/tissues related to Lymph Node Disease:

⁴¹

Lymph Node, T Cells, Thyroid, Prostate, Testes, Lung

Sources

Publications for Lymph Node Disease

Articles related to Lymph Node Disease:

(show all 24)

#	Title	Authors	Year
1	Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer: What Is the Best Approach? ( 28107261 )	NegrALo M.V....da Costa Miranda V.	2017
2	Letter to the Editor on &quot;Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer&quot;: What is the Best Approach? Int J Gynecol Cancer. 2017 Mar; 27(3): 543549. ( 28708789 )	Chantalat E....Motton S.	2017
3	Axillary Ultrasound Accurately Excludes Clinically Significant Lymph Node Disease in Patients With Early Stage Breast Cancer. ( 26779976 )	Tucker N.S....Gillanders W.E.	2016
4	Unexpected lymph node disease in resections for pulmonary metastases. ( 25440271 )	Seebacher G....Graeter T.P.	2015
5	The prognosis of N2b and N2c lymph node disease in oral squamous cell carcinoma is determined by the number of metastatic lymph nodes rather than laterality: evidence to support a revision of the American Joint Committee on Cancer staging system. ( 24691658 )	Ebrahimi A....Clark J.R.	2014
6	Is Minimal Residual Lymph Node Disease in Papillary Thyroid Cancer of Prognostic Impact? An Analysis of The Epithelial Cell Adhesion Molecule EpCAM in Lymph Nodes of 40 pN0 Patients. ( 23918549 )	Rehders A....Knoefel W.T.	2014
7	Critical analysis of the 2010 TNM classification in patients with lymph node-positive bladder cancer: influence of lymph node disease burden. ( 25027685 )	Pedrosa J.A....Cheng L.	2014
8	Clinical feasibility and diagnostic accuracy of detecting micrometastatic lymph node disease in sentinel and non-sentinel lyph nodes in cervical cancer: outcomes and implications. ( 24505957 )	Sniadecki M....Wydra D.	2014
9	The impact of lymph node disease in extremity soft-tissue sarcomas: a population-based analysis. ( 23806824 )	Johannesmeyer D....Camp E.R.	2013
10	Survival of patients with non-small cell lung cancer according to lymph node disease: single pN1 vs multiple pN1 vs single unsuspected pN2. ( 23378017 )	Macia I....Rodriguez-Taboada P.	2013
11	Imaging response and residual metastatic axillary lymph node disease after neoadjuvant chemotherapy for primary breast cancer. ( 23846781 )	Hieken T.J....Glazebrook K.N.	2013
12	Residual lymph node disease after neoadjuvant chemotherapy predicts an increased risk of lymphedema in node-positive breast cancer patients. ( 23689935 )	Specht M.C....Taghian A.G.	2013
13	Subcutaneous emphysema as the first relevant clinical sign of complicated tubercular lymph node disease in a child. ( 24094042 )	Esposito S....Principi N.	2013
14	Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer. ( 22120175 )	Cibula D....Zweemer R.P.	2012
15	Is Warthin's tumour of the parotid gland a lymph node disease? ( 21771031 )	Teymoortash A....Moll R.	2011
16	Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group. ( 21357792 )	Rodeberg D.A....Hawkins D.S.	2011
17	Micrometastatic sentinel lymph node disease: do patients benefit or suffer harm from axillary lymph node dissection? ( 19937389 )	Ziogas D....Zografos G.C.	2010
18	Minimal disease in the sentinel lymph node: how to best measure sentinel node micrometastases to predict risk of additional non-sentinel lymph node disease. ( 20532987 )	Kumar S....Van Zee K.J.	2010
19	Epithelial ovarian cancer relapsing as isolated lymph node disease: natural history and clinical outcome. ( 19077269 )	Legge F....Ferrandina G.	2008
20	Lymph node disease after radical prostatectomy. ( 17431370 )	Wirth M.P....Froehner M.	2007
21	Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature. ( 17916603 )	Nicastri D.G....Hughes S.J.	2007
22	Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage IIIA-N2 Non-small-cell lung cancer: a Leuven Lung Cancer Group Study. ( 16849747 )	De Leyn P....Vansteenkiste J.	2006
23	High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease. ( 16649220 )	Veness M.J....Morgan G.J.	2006
24	Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma. ( 15912516 )	Wiegand S....Werner J.A.	2005

Sources

Genes for Lymph Node Disease

Genes related to Lymph Node Disease (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MMP3	Matrix Metallopeptidase 3	Protein Coding	20.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	CA8	Carbonic Anhydrase 8	Protein Coding	18.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	17.96	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	ITPKC	Inositol-Trisphosphate 3-Kinase C	Protein Coding	17.89	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	17.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	17.21	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	TMEM127	Transmembrane Protein 127	Protein Coding	17.21	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	CRP	C-Reactive Protein	Protein Coding	17.09	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	16.93	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	CD40LG	CD40 Ligand	Protein Coding	16.79	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	MMP14	Matrix Metallopeptidase 14	Protein Coding	16.76	GeneCards inferred via : Publications (show sections)
12	EPCAM	Epithelial Cell Adhesion Molecule	Protein Coding	16.76	GeneCards inferred via : Publications (show sections)
13	MMP1	Matrix Metallopeptidase 1	Protein Coding	16.76	GeneCards inferred via : Publications (show sections)
14	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	16.42	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	TNF	Tumor Necrosis Factor	Protein Coding	16.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	CD79A	CD79a Molecule	Protein Coding	16.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
17	IL6	Interleukin 6	Protein Coding	16.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
18	ITGAE	Integrin Subunit Alpha E	Protein Coding	16.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
19	PGLS	6-Phosphogluconolactonase	Protein Coding	8.68	DISEASES inferred ¹⁵
20	ENSG00000255292		Protein Coding	7.62	DISEASES inferred ¹⁵

Sources

Variations for Lymph Node Disease

Sources

Expression for Lymph Node Disease

Search GEO for disease gene expression data for Lymph Node Disease.

Sources

Pathways for Lymph Node Disease

Pathways related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.17	IL6 MMP1 MMP3 TNF
2	Colorectal Cancer Metastasis ⁶⁴	12.03	IL6 MMP1 MMP14 TNF
3	Carbon metabolism ³⁷ Show member pathways 2-Oxocarboxylic acid metabolism ³⁷ Biosynthesis of amino acids ³⁷ formaldehyde oxidation ¹	11.98	PGLS SDHA SDHB SDHC SDHD
4	Pyruvate metabolism and Citric Acid (TCA) cycle ⁶⁶ Show member pathways Citric acid cycle (TCA cycle) ⁶⁶ Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ⁶⁶ NAD phosphorylation and dephosphorylation ¹ Pyruvate metabolism ⁶⁶ Regulation of pyruvate dehydrogenase (PDH) complex ⁶⁶ TCA Cycle ¹	11.9	SDHA SDHB SDHC SDHD
5	Interleukin-4 and 13 signaling ⁶⁶	11.81	IL6 MMP1 MMP3 TNF
6	TNF signaling pathway ³⁷	11.77	IL6 MMP14 MMP3 TNF
7	Citrate cycle (TCA cycle) ³⁷ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.72	SDHA SDHB SDHC SDHD
8	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.66	MMP1 MMP14 MMP3 TNF
9	Rheumatoid arthritis ³⁷	11.58	IL6 MMP1 MMP3 TNF
10	Cell adhesion_ECM remodeling ²²	11.49	MMP1 MMP14 MMP3
11	Malaria ³⁷	11.36	CD40LG IL6 TNF
12	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.13	EPCAM IL6 ITGAE TNF
13	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	10.82	CD40LG IL6 MMP1 MMP3 TNF
14	Overview of nanoparticle effects ¹	10.61	CRP IL6 TNF

Sources

GO Terms for Lymph Node Disease

Cellular components related to Lymph Node Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial inner membrane	GO:0005743	9.55	ENSG00000255292 SDHA SDHB SDHC SDHD
2	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	9.02	ENSG00000255292 SDHA SDHB SDHC SDHD
3	respiratory chain complex II	GO:0045273	8.96	SDHB SDHC

Biological processes related to Lymph Node Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	electron transport chain	GO:0022900	9.61	SDHA SDHB SDHC
2	extracellular matrix disassembly	GO:0022617	9.58	MMP1 MMP14 MMP3
3	collagen catabolic process	GO:0030574	9.5	MMP1 MMP14 MMP3
4	tricarboxylic acid cycle	GO:0006099	9.43	ENSG00000255292 SDHA SDHAF2 SDHB SDHC SDHD
5	succinate metabolic process	GO:0006105	9.37	SDHA SDHB
6	negative regulation of lipid storage	GO:0010888	9.33	CRP IL6 TNF
7	regulation of immunoglobulin secretion	GO:0051023	9.26	CD40LG TNF
8	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	9.02	ENSG00000255292 SDHA SDHAF2 SDHC SDHD

Molecular functions related to Lymph Node Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	electron transfer activity	GO:0009055	9.56	SDHA SDHB SDHC SDHD
2	ubiquinone binding	GO:0048039	9.33	ENSG00000255292 SDHB SDHD
3	succinate dehydrogenase activity	GO:0000104	9.13	SDHA SDHC SDHD
4	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.02	ENSG00000255292 SDHA SDHB SDHC SDHD

Sources

Sources for Lymph Node Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia