Aliases & Classifications for Lymph Node Disease

MalaCards integrated aliases for Lymph Node Disease:

Name: Lymph Node Disease 12 15
Disorder of Lymph Node 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9942
NCIt 50 C35346
SNOMED-CT 68 76616003
UMLS 73 C0272394

Summaries for Lymph Node Disease

MalaCards based summary : Lymph Node Disease, also known as disorder of lymph node, is related to persistent generalized lymphadenopathy and superior limbic keratoconjunctivitis, and has symptoms including axillary lymph node pain, inguinal lymph node pain and inguinal lymph node tenderness. An important gene associated with Lymph Node Disease is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Colorectal Cancer Metastasis. The drugs Cisplatin and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and thyroid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Lymph Node Disease

Diseases related to Lymph Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 persistent generalized lymphadenopathy 29.3 CD40LG CD79A SDHA SDHAF2 SDHB SDHC
2 superior limbic keratoconjunctivitis 11.1 MMP1 MMP3
3 spastic entropion 10.9 MMP1 MMP3
4 paragangliomas 1 10.7 SDHB SDHC SDHD
5 chondroma 10.7 SDHB SDHC SDHD
6 paraganglioma and gastric stromal sarcoma 10.7 SDHB SDHC SDHD
7 sporadic pheochromocytoma 10.7 SDHB SDHC SDHD
8 borderline leprosy 10.7 CD40LG SDHD
9 selective igg deficiency disease 10.6 CD40LG CD79A
10 neurofibromatosis, type iv, of riccardi 10.6 SDHB SDHC SDHD
11 c1q nephropathy 10.6 CD40LG CD79A
12 multiple cranial nerve palsy 10.6 CD40LG CRP MMP3
13 von hippel-lindau syndrome 10.6 SDHB SDHC SDHD
14 meningovascular neurosyphilis 10.6 CD40LG CD79A
15 alpha chain disease 10.6 CD40LG CD79A
16 brill-zinsser disease 10.6 CD40LG CD79A
17 exudative glomerulonephritis 10.6 CD40LG CD79A
18 cork-handlers' disease 10.6 CD40LG CD79A
19 cowden disease 10.6 SDHB SDHC SDHD
20 salpingo-oophoritis 10.5 CD40LG CD79A
21 early yaws 10.5 CD40LG CD79A
22 ventilation pneumonitis 10.5 CD40LG CD79A
23 chronic interstitial cystitis 10.5 CD40LG CD79A
24 axillary adenitis 10.5 CD40LG CD79A
25 cryofibrinogenemia 10.5 CD40LG CD79A
26 acalculous cholecystitis 10.5 CD40LG CRP
27 cold agglutinin disease 10.5 CRP IL6
28 rheumatoid lung disease 10.5 CD40LG MMP3 TNF
29 trichostrongyloidiasis 10.5 CD40LG CD79A
30 subacute bacterial endocarditis 10.5 CD40LG CD79A
31 heterophyiasis 10.5 CD40LG CD79A
32 immunoglobulin g deficiency 10.5 CD40LG CD79A
33 orbital granuloma 10.4 CD40LG CD79A
34 transient hypogammaglobulinemia of infancy 10.4 CD40LG CD79A
35 carotid stenosis 10.4 CRP MMP1 TNF
36 scorpion envenomation 10.4 IL6 TNF
37 intestinal tuberculosis 10.4 CD79A CRP
38 hyperglobulinemic purpura 10.4 CD40LG CD79A
39 fibrosarcoma 10.4 MMP1 MMP14 MMP3 TNF
40 gastroduodenitis 10.4 CD40LG CD79A
41 periodontitis, chronic 10.4 IL6 MMP1
42 bacterial conjunctivitis 10.4 CD40LG CD79A
43 heavy chain disease 10.4 CD40LG CD79A
44 adrenal medulla cancer 10.4 SDHAF2 SDHB SDHC SDHD
45 extra-adrenal pheochromocytoma 10.4 SDHAF2 SDHB SDHC SDHD
46 mononeuritis multiplex 10.3 CD40LG CRP
47 streptococcal meningitis 10.3 CD40LG CRP TNF
48 scrub typhus 10.3 CD40LG CRP TNF
49 ophthalmia neonatorum 10.3 CD40LG CD79A
50 leukomalacia 10.3 IL6 TNF

Graphical network of the top 20 diseases related to Lymph Node Disease:



Diseases related to Lymph Node Disease

Symptoms & Phenotypes for Lymph Node Disease

UMLS symptoms related to Lymph Node Disease:


axillary lymph node pain, inguinal lymph node pain, inguinal lymph node tenderness

MGI Mouse Phenotypes related to Lymph Node Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 SDHB SDHC SDHD TMEM127 TNF CD40LG
2 homeostasis/metabolism MP:0005376 9.8 CD40LG CD79A CRP EPCAM IL6 MMP1
3 immune system MP:0005387 9.4 TMEM127 TNF CD40LG CD79A CRP EPCAM

Drugs & Therapeutics for Lymph Node Disease

Drugs for Lymph Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
3
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
4
Docetaxel Approved, Investigational Phase 3,Phase 2 114977-28-5 148124
5 Estrogens Phase 3
6 Antimetabolites Phase 3
7 Antimetabolites, Antineoplastic Phase 3
8 Antimitotic Agents Phase 3,Phase 2
9
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
10
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
11
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
12
Doxil Approved June 1999 Phase 2 31703
13 Anti-Bacterial Agents Phase 2
14 Antibiotics, Antitubercular Phase 2
15 Alkylating Agents Phase 2
16 Topoisomerase Inhibitors Phase 2
17 Immunosuppressive Agents Phase 2
18 Antirheumatic Agents Phase 2
19 Antineoplastic Agents, Alkylating Phase 2
20
Inosine pranobex Approved Not Applicable 36703-88-5
21 interferons Not Applicable
22 Anti-Infective Agents Not Applicable
23 Interferon-alpha Not Applicable
24 Antiviral Agents Not Applicable
25 Adjuvants, Immunologic Not Applicable

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes Completed NCT00287196 Phase 3
2 Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy Recruiting NCT01901094 Phase 3
3 Definitive Chemo-Radiotherapy for Regionally Advanced Head and Neck Cancer With or Without Up-front Neck Dissection Recruiting NCT02918955 Phase 3 Chemotherapy (Cisplatin)
4 Genetic Testing or Clinical Assessment in Determining the Need for Chemotherapy in Women With Breast Cancer That Involves No More Than 3 Lymph Nodes Active, not recruiting NCT00433589 Phase 3 anthracycline-based;docetaxel and capecitabine
5 Depsipeptide to Treat Patients With Cutaneous T-Cell Lymphoma and Peripheral T-Cell Lymphoma Completed NCT00007345 Phase 2 Romidepsin
6 Fluorescence Targeted Pelvic Lymph Node Mapping Enrolling by invitation NCT03204994 Phase 1, Phase 2 Indocyanine Green
7 Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in Early Stage Breast Cancer Terminated NCT00636441 Phase 2 Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC)
8 Recombinant Interferon Alfa-2b in Treating Patients With Melanoma Unknown status NCT01460875 Not Applicable
9 Bronchoscopic Sampling Techniques in Sarcoidosis Unknown status NCT01836822 Not Applicable
10 A Study of Isoprinosine in Patients With Lymph Node Disease Completed NCT00002297 Not Applicable Inosine pranobex
11 The Safety and Effectiveness of Isoprinosine in Patients With Weakened Immune Systems and Lymph Node Disease Completed NCT00002296 Not Applicable Inosine pranobex
12 CT Detection of Metastatic Lymphadenopathy in Papillary Thyroid Cancer Completed NCT03359668 Not Applicable
13 LYMPHA: Eliminating the Burden of Lymphedema in Patients Requiring Nodal Dissection Recruiting NCT03073096 Not Applicable
14 Radiotherapy of Pelvic Lymph Nodes in High Risk Prostate Cancer - A Retrospective Analysis Recruiting NCT02998619
15 MR-guided RAdiotherapy to Breast With Dose Escalation to regionaL Lymph NodEs Recruiting NCT03405519 Not Applicable
16 Unlock the Cell: Castleman's Disease Flow Cytometry Study Recruiting NCT02853968
17 Evolution of Indications for Transbronchial Ganglionic Ultrasound in the Picardie Region Over the Period 2008 - 2013 Not yet recruiting NCT03132883
18 Dynamic Contrast Enhanced Computed Tomography (CT) for Head and Neck Cancer Terminated NCT01549379 Not Applicable

Search NIH Clinical Center for Lymph Node Disease

Genetic Tests for Lymph Node Disease

Anatomical Context for Lymph Node Disease

MalaCards organs/tissues related to Lymph Node Disease:

41
Lymph Node, T Cells, Thyroid, Prostate, Testes, Lung

Publications for Lymph Node Disease

Articles related to Lymph Node Disease:

(show all 24)
# Title Authors Year
1
Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer: What Is the Best Approach? ( 28107261 )
2017
2
Letter to the Editor on "Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer": What is the Best Approach? Int J Gynecol Cancer. 2017 Mar; 27(3): 543549. ( 28708789 )
2017
3
Axillary Ultrasound Accurately Excludes Clinically Significant Lymph Node Disease in Patients With Early Stage Breast Cancer. ( 26779976 )
2016
4
Unexpected lymph node disease in resections for pulmonary metastases. ( 25440271 )
2015
5
The prognosis of N2b and N2c lymph node disease in oral squamous cell carcinoma is determined by the number of metastatic lymph nodes rather than laterality: evidence to support a revision of the American Joint Committee on Cancer staging system. ( 24691658 )
2014
6
Is Minimal Residual Lymph Node Disease in Papillary Thyroid Cancer of Prognostic Impact? An Analysis of The Epithelial Cell Adhesion Molecule EpCAM in Lymph Nodes of 40 pN0 Patients. ( 23918549 )
2014
7
Critical analysis of the 2010 TNM classification in patients with lymph node-positive bladder cancer: influence of lymph node disease burden. ( 25027685 )
2014
8
Clinical feasibility and diagnostic accuracy of detecting micrometastatic lymph node disease in sentinel and non-sentinel lyph nodes in cervical cancer: outcomes and implications. ( 24505957 )
2014
9
The impact of lymph node disease in extremity soft-tissue sarcomas: a population-based analysis. ( 23806824 )
2013
10
Survival of patients with non-small cell lung cancer according to lymph node disease: single pN1 vs multiple pN1 vs single unsuspected pN2. ( 23378017 )
2013
11
Imaging response and residual metastatic axillary lymph node disease after neoadjuvant chemotherapy for primary breast cancer. ( 23846781 )
2013
12
Residual lymph node disease after neoadjuvant chemotherapy predicts an increased risk of lymphedema in node-positive breast cancer patients. ( 23689935 )
2013
13
Subcutaneous emphysema as the first relevant clinical sign of complicated tubercular lymph node disease in a child. ( 24094042 )
2013
14
Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer. ( 22120175 )
2012
15
Is Warthin's tumour of the parotid gland a lymph node disease? ( 21771031 )
2011
16
Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group. ( 21357792 )
2011
17
Micrometastatic sentinel lymph node disease: do patients benefit or suffer harm from axillary lymph node dissection? ( 19937389 )
2010
18
Minimal disease in the sentinel lymph node: how to best measure sentinel node micrometastases to predict risk of additional non-sentinel lymph node disease. ( 20532987 )
2010
19
Epithelial ovarian cancer relapsing as isolated lymph node disease: natural history and clinical outcome. ( 19077269 )
2008
20
Lymph node disease after radical prostatectomy. ( 17431370 )
2007
21
Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature. ( 17916603 )
2007
22
Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage IIIA-N2 Non-small-cell lung cancer: a Leuven Lung Cancer Group Study. ( 16849747 )
2006
23
High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease. ( 16649220 )
2006
24
Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma. ( 15912516 )
2005

Variations for Lymph Node Disease

Expression for Lymph Node Disease

Search GEO for disease gene expression data for Lymph Node Disease.

Pathways for Lymph Node Disease

Pathways related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.17 IL6 MMP1 MMP3 TNF
2 12.03 IL6 MMP1 MMP14 TNF
3
Show member pathways
11.98 PGLS SDHA SDHB SDHC SDHD
4
Show member pathways
11.9 SDHA SDHB SDHC SDHD
5 11.81 IL6 MMP1 MMP3 TNF
6 11.77 IL6 MMP14 MMP3 TNF
7
Show member pathways
11.72 SDHA SDHB SDHC SDHD
8
Show member pathways
11.66 MMP1 MMP14 MMP3 TNF
9 11.58 IL6 MMP1 MMP3 TNF
10 11.49 MMP1 MMP14 MMP3
11 11.36 CD40LG IL6 TNF
12 11.13 EPCAM IL6 ITGAE TNF
13
Show member pathways
10.82 CD40LG IL6 MMP1 MMP3 TNF
14 10.61 CRP IL6 TNF

GO Terms for Lymph Node Disease

Cellular components related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.55 ENSG00000255292 SDHA SDHB SDHC SDHD
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.02 ENSG00000255292 SDHA SDHB SDHC SDHD
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC

Biological processes related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transport chain GO:0022900 9.61 SDHA SDHB SDHC
2 extracellular matrix disassembly GO:0022617 9.58 MMP1 MMP14 MMP3
3 collagen catabolic process GO:0030574 9.5 MMP1 MMP14 MMP3
4 tricarboxylic acid cycle GO:0006099 9.43 ENSG00000255292 SDHA SDHAF2 SDHB SDHC SDHD
5 succinate metabolic process GO:0006105 9.37 SDHA SDHB
6 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
7 regulation of immunoglobulin secretion GO:0051023 9.26 CD40LG TNF
8 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.02 ENSG00000255292 SDHA SDHAF2 SDHC SDHD

Molecular functions related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.56 SDHA SDHB SDHC SDHD
2 ubiquinone binding GO:0048039 9.33 ENSG00000255292 SDHB SDHD
3 succinate dehydrogenase activity GO:0000104 9.13 SDHA SDHC SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.02 ENSG00000255292 SDHA SDHB SDHC SDHD

Sources for Lymph Node Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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