Aliases & Classifications for Lymph Node Disease

MalaCards integrated aliases for Lymph Node Disease:

Name: Lymph Node Disease 12 15
Disorder of Lymph Node 70


External Ids:

Disease Ontology 12 DOID:9942
NCIt 50 C35346
SNOMED-CT 67 76616003
UMLS 70 C0272394

Summaries for Lymph Node Disease

MalaCards based summary : Lymph Node Disease, also known as disorder of lymph node, is related to persistent generalized lymphadenopathy and squamous cell carcinoma, head and neck, and has symptoms including axillary lymph node pain, inguinal lymph node pain and inguinal lymph node tenderness. An important gene associated with Lymph Node Disease is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are Allograft rejection and Prion disease. The drugs Cisplatin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include lymph node, prostate and pancreas, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Lymph Node Disease

Diseases related to Lymph Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 602)
# Related Disease Score Top Affiliating Genes
1 persistent generalized lymphadenopathy 31.9 TMEM127 SERPINA3 SDHD SDHC SDHB SDHAF2
2 squamous cell carcinoma, head and neck 30.5 MMP3 MMP1 MIR145 EPCAM CCR6
3 superior limbic keratoconjunctivitis 10.6 MMP3 MMP1
4 coronary artery aneurysm 10.5 MMP3 MMP1
5 spastic entropion 10.5 MMP3 MMP1
6 sporadic pheochromocytoma/secreting paraganglioma 10.5 SDHD SDHB
7 cork-handlers' disease 10.5 CD8A CD4
8 necrotic uveal melanoma 10.5 CD8A CD4
9 tendinopathy 10.5 MMP3 MMP1
10 suppurative lymphadenitis 10.5 CRP CD4 CCR6
11 early yaws 10.5 CD8A CD4
12 plethora of newborn 10.5 SDHD SDHB
13 drug reaction with eosinophilia and systemic symptoms 10.5 TNF CRP
14 ventilation pneumonitis 10.5 CD8A CD4
15 polyclonal hypergammaglobulinemia 10.5 SERPINA3 CRP CD4
16 viral meningitis 10.5 MMP3 MMP1 CRP
17 mucormycosis 10.5 CRP CD4 CCR6
18 punctate inner choroidopathy 10.5 TNF IL10
19 pelvic organ prolapse 10.5 MMP3 MMP1 CCR6
20 panophthalmitis 10.5 CRP CD4
21 esophageal candidiasis 10.5 CD8A CD4 CCR6
22 igg4-related disease 10.5 ICOSLG CRP CCR6
23 papilledema 10.5 SERPINA3 CRP CD4
24 henoch-schoenlein purpura 10.5 SERPINA3 ICOSLG CRP
25 autonomic nervous system benign neoplasm 10.5 TMEM127 SDHD SDHB
26 bursitis 10.5 TNF MMP3 CRP
27 tropical endomyocardial fibrosis 10.5 TNF IL10
28 peripheral nervous system benign neoplasm 10.5 TMEM127 SDHD SDHB
29 autoimmune cholangitis 10.5 CD8A CD4 CCR6
30 bullous skin disease 10.5 ICOSLG CD4 CCR6
31 primary syphilis 10.5 CRP CD8A CD4
32 diffuse infiltrative lymphocytosis syndrome 10.5 CD8A CD4
33 toxic megacolon 10.5 TNF CRP CCR6
34 bone deterioration disease 10.5 TNF MMP3 MMP1
35 immunodeficiency with hyper-igm, type 3 10.5 ICOSLG CD8A CD4
36 aspiration pneumonitis 10.5 TNF SERPINA3 CRP
37 rheumatoid arthritis interstitial lung disease 10.5 TNF CRP CD4
38 secondary syphilis 10.5 CRP CD8A CD4
39 parotid disease 10.5 CRP CD8A CD4
40 pustulosis of palm and sole 10.5 TNF CRP CCR6
41 subcutaneous mycosis 10.5 IL10 CD4 CCR6
42 meningovascular neurosyphilis 10.5 TNF CRP CD4
43 spondyloarthropathy 10.5 TNF MMP3 IL10
44 opportunistic bacterial infectious disease 10.5 TNF CRP CD4
45 tendinitis 10.5 TNF MMP3 CRP
46 thrombocytopenic purpura, autoimmune 10.5 ICOSLG CD4 CCR6
47 nocardiosis 10.5 TNF CRP CD4
48 arachnoiditis 10.5 TNF CRP CD4
49 gastrointestinal tuberculosis 10.5 TNF CRP CD4
50 intestinal tuberculosis 10.5 TNF CRP CD4

Graphical network of the top 20 diseases related to Lymph Node Disease:

Diseases related to Lymph Node Disease

Symptoms & Phenotypes for Lymph Node Disease

UMLS symptoms related to Lymph Node Disease:

axillary lymph node pain; inguinal lymph node pain; inguinal lymph node tenderness

MGI Mouse Phenotypes related to Lymph Node Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 CCR6 CD4 CD8A EPCAM IL10 ITPKC
2 homeostasis/metabolism MP:0005376 9.8 CCR6 CD4 CRP EPCAM IL10 MMP1
3 immune system MP:0005387 9.4 CCR6 CD4 CD8A CRP EPCAM IL10

Drugs & Therapeutics for Lymph Node Disease

Drugs for Lymph Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
5 Tubulin Modulators Phase 3
6 Antimitotic Agents Phase 3
7 Estrogens Phase 3
8 Antimetabolites Phase 3
Ipilimumab Approved Phase 2 477202-00-9
nivolumab Approved Phase 2 946414-94-4
11 Antineoplastic Agents, Immunological Phase 2
12 Antibodies Phase 2
13 Immunoglobulins Phase 2
Pancrelipase Approved, Investigational 53608-75-6
Imidacloprid Vet_approved 105827-78-9 86418
16 pancreatin
17 Immunologic Factors
18 Antiviral Agents
19 Interferon alpha-2
20 Interferon-alpha
21 interferons
22 Anti-Infective Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Definitive Chemo-Radiotherapy With or Without Up-front Neck Dissection for Regionally Advanced Head and Neck Squamous Cell Carcinoma: A Phase III Multi-center Prospective Randomized Controlled Trial With Two Additional Observational Cohorts Recruiting NCT02918955 Phase 3 Chemotherapy (Cisplatin)
2 A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy Recruiting NCT01901094 Phase 3
3 MINDACT (Microarray In Node-Negative and 1 to 3 Positive Lymph Node Disease May Avoid Chemotherapy): A Prospective, Randomized Study Comparing the 70-Gene Signature With the Common Clinical-Pathological Criteria in Selecting Patients for Adjuvant Chemotherapy in Breast Cancer With 0 to 3 Positive Nodes Active, not recruiting NCT00433589 Phase 3 anthracycline-based;docetaxel and capecitabine
4 Neoadjuvant Phase II Study of TLR9 Agonist CMP-001 in Combination With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease Active, not recruiting NCT03618641 Phase 2 CMP-001
5 Role of Color Doppler Ultrasound in Differentiation Between Benign and Malignant Lymphadenopathy Unknown status NCT03760094
6 Performing a Lymphatic-venous Anastomosis at Time of Nodal Dissection in Patients Requiring Complete Axillary or Groin Dissection for the Prevention of Lymphedema Unknown status NCT03073096
7 Comparion of 22G-ProCore and 22G-Standard Needle in Diagnosis of Lymphadenopathy Via EBUS-TBNA: A Prospective, Multicenter, Randomized Controlled Clinical Trial Unknown status NCT03903471
8 Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®) in Tumors of the Pancreas, Submucosal Tumors and Lymph Node Disease of the Upper GI Tract Unknown status NCT03621852
9 Pilot Study of IFN-alpha-2b Dose Reduction With Dose Optimization Completed NCT01460875
10 Identifying Ultrasonic Diagnostic Characteristics of Cervical Lymphadenopathy: A Retrospective, Multicenter Study Completed NCT04497714
11 Prediction Model Based on Deep Learning of CP-EBUS Multimodal Image in the Diagnosis of Benign and Malignant Lymph Nodes Recruiting NCT04328792

Search NIH Clinical Center for Lymph Node Disease

Genetic Tests for Lymph Node Disease

Anatomical Context for Lymph Node Disease

MalaCards organs/tissues related to Lymph Node Disease:

Lymph Node, Prostate, Pancreas, Colon, Cervix, Bone Marrow, Lung

Publications for Lymph Node Disease

Articles related to Lymph Node Disease:

(show top 50) (show all 537)
# Title Authors PMID Year
Diagnostic Performance of Noninvasive Imaging for Assessment of Axillary Response After Neoadjuvant Systemic Therapy in Clinically Node-positive Breast Cancer: A Systematic Review and Meta-analysis. 61
33201095 2021
Stage IIIa Melanoma and Impact of Multiple Positive Lymph Nodes on Survival. 61
33316426 2021
[Penile Cancer: A case for non-lymph node disease following a negative sentinel node exploration.] 61
33650543 2021
Multiparametric MRI with in-bore targeted biopsy in the diagnostic pathway of prostate cancer: Data from a single institution experience. 61
33676850 2021
Response in breast vs axilla after neoadjuvant treatment and implications for nonoperative management of invasive breast cancer. 61
33393166 2021
Utility of sonography for identifying metastatic cervical adenopathy in children with differentiated thyroid carcinoma at presentation. 61
33030586 2021
Axillary lymph node metastasis: Fine-needle aspiration biopsy sensitivity as a function of node size, percent replacement of lymph node by tumor and tumor deposit size. 61
32945140 2021
Examination of factors associated with lymph node metastases in lung carcinoids: Results from a single institution retrospective cohort study. 61
33551175 2021
Should metastatic lymph nodes be considered at the same clinical stage as distant metastasis in soft tissue sarcomas? 61
33340903 2021
Radiotherapy plus chemotherapy versus chemotherapy alone in penile cancer patients with extracapsular nodal extension after inguinal lymph node surgery: a multi-institutional study. 61
32303900 2021
Clinical Manifestations Associated with Bartonella henselae Infection in a Tropical Region. 61
33021197 2021
Melanoma of Unknown Primary: Evaluation of the Characteristics, Treatment Strategies, Prognostic Factors in a Monocentric Retrospective Study. 61
33747946 2021
Recent Evolution in the Management of Lymph Node Metastases in Melanoma. 61
33763181 2021
Applicability of sentinel lymph node oriented treatment strategy for gallbladder cancer. 61
33577620 2021
Inguinal lymph node dissection for penile cancer: a contemporary review. 61
33457292 2020
Predictive factors of non-sentinel lymph node disease in breast cancer patients with positive sentinel lymph node. 61
33358014 2020
High Mitotic Rate Predicts Sentinel Lymph Node Involvement in Thin Melanomas. 61
32711176 2020
[Tuberculosis in the paediatric age group: A reflection on transmission]. 61
33262096 2020
Long-Term Toxicity and Efficacy of Intensity-Modulated Radiation Therapy in Cervical Cancers: Experience of a Cancer Hospital in Pakistan. 61
33112682 2020
Regional Lymph Node Involvement Among Patients With De Novo Metastatic Breast Cancer. 61
33034638 2020
[Clinic analysis of cervical lymph node lesions in children]. 61
33254300 2020
Cost-effectiveness analysis of the 70-gene signature compared with clinical assessment in breast cancer based on a randomised controlled trial. 61
32795875 2020
[Primary intraosseous Rosai-Dorfman disease: a clinicopathological analysis of fourteen cases]. 61
32892555 2020
How should we stage and tailor treatment strategy in locally advanced cervical cancer? Imaging versus para-aortic surgical staging. 61
32788263 2020
Can lymphadenectomy be omitted in advanced ovarian cancer?-a brief review. 61
32527112 2020
Impact of pathologic lymph node-positive renal cell carcinoma on survival in patients without metastasis: Evidence in support of expanding the definition of stage IV kidney cancer. 61
32329899 2020
FDG-PET/CT scan assessment of response 12 weeks post radical radiotherapy in oropharynx head and neck cancer: The impact of p16 status. 61
32294581 2020
External evaluation of the Briganti nomogram to predict lymph node metastases in intermediate-risk prostate cancer patients. 61
32583038 2020
Kikuchi disease as a possible cause of ischaemic stroke: a case report. 61
32351150 2020
Performance of models predicting residual lymph node disease in melanoma patients following sentinel lymph node biopsy. 61
32222274 2020
Is the involvement of the hepatic artery lymph node a poor prognostic factor in pancreatic adenocarcinoma? 61
31839175 2020
Does hipec improve outcomes in gastric cancer patients treated with perioperative chemotherapy and radical surgery? A propensity-score matched analysis. 61
31950511 2020
Does small volume metastatic lymph node disease affect long-term prognosis in early cervical cancer? 61
31871114 2020
Performance of [68Ga] Ga-PSMA 11 PET for detecting prostate cancer in the lymph nodes before salvage lymph node dissection: a systematic review and meta-analysis. 61
31147628 2020
A Large, Multicenter, Retrospective Study on Efficacy and Safety of Stereotactic Body Radiotherapy (SBRT) in Oligometastatic Ovarian Cancer (MITO RT1 Study): A Collaboration of MITO, AIRO GYN, and MaNGO Groups. 61
32043791 2020
Brachial plexus schwannoma mimicking advanced breast carcinoma. 61
32083563 2020
FDG PET-CT in pediatric Langerhans cell histiocytosis. 61
31599488 2020
Impact of the 8th edition of the AJCC TNM classification on gastric cancer prognosis-study of a western cohort. 61
33209115 2020
Mummified Cells are a Common Finding in Cutaneous Hodgkin Lymphoma and Can Be Used as a Diagnostic Clue. 61
31169526 2020
Advances in axillary surgery for breast cancer 2019. 61
31240726 2020
Recurrent ilioinguinal lymph node metastasis from primary anal adenocarcinoma: what should we do?-A case report and review of literature. 61
32492641 2020
Primary Merkel Cell Carcinoma: The Clinical Experience of Taipei Veterans General Hospital Revisited. 61
31833886 2020
Patterns of recurrence after prostate bed radiotherapy. 61
31563410 2019
Preoperative Computed Tomography Changes Surgical Management for Clinically Low-Risk Well-Differentiated Thyroid Cancer. 61
31583547 2019
Impact of adjuvant chemotherapy regimen on survival outcomes in immunohistochemical subtypes of ampullary carcinoma. 61
31840257 2019
Effectiveness of radiotherapy for head and neck skin cancers: a single-institution study. 61
31918468 2019
Stereotactic body radiotherapy for bone oligometastatic disease in prostate cancer. 61
31346760 2019
Radical Cystectomy in Female Patients - Improving Outcomes. 61
31781877 2019
A systematic review of the effectiveness of adjuvant therapy for patients with gallbladder cancer. 61
30922845 2019
Neuroendocrine Tumors of Meckel's Diverticula: Rare but Fare Well. 61
31657307 2019

Variations for Lymph Node Disease

Expression for Lymph Node Disease

Search GEO for disease gene expression data for Lymph Node Disease.

Pathways for Lymph Node Disease

Pathways related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
4 11.89 TNF IL10 CD8A CD4
Show member pathways
6 11.77 TNF IL10 CD8A CD4
7 11.73 TNF MMP3 MMP1 IL10
Show member pathways
11.57 TNF IL10 CD4
Show member pathways
Show member pathways
11.45 TNF MMP3 MMP1
11 11.28 TNF IL10 ICOSLG CCR6
12 11.26 TNF IL10 CD8A CD4 CCR6
13 10.96 TNF IL10 CD4
14 10.89 TNF IL10 EPCAM CD8A CD4

GO Terms for Lymph Node Disease

Cellular components related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.55 TNF ICOSLG CD8A CD4 CCR6
2 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 TNF IL10 CD8A CD4 CCR6
2 electron transport chain GO:0022900 9.69 SDHC SDHB SDHA
3 positive regulation of protein complex assembly GO:0031334 9.58 TNF MMP3 MMP1
4 cytokine-mediated signaling pathway GO:0019221 9.55 TNF MMP3 MMP1 IL10 CD4
5 cellular response to UV-A GO:0071492 9.49 MMP3 MMP1
6 negative regulation of lipid storage GO:0010888 9.46 TNF CRP
7 endothelial cell apoptotic process GO:0072577 9.43 TNF IL10
8 T cell activation GO:0042110 9.43 ICOSLG CD8A CD4
9 succinate metabolic process GO:0006105 9.37 SDHB SDHA
10 tricarboxylic acid cycle GO:0006099 9.35 SDHD SDHC SDHB SDHAF2 SDHA
11 negative regulation of cytokine production involved in immune response GO:0002719 9.32 TNF IL10
12 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 SDHD SDHC SDHAF2 SDHA

Molecular functions related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 9.26 SDHD SDHB
2 electron transfer activity GO:0009055 9.26 SDHD SDHC SDHB SDHA
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.16 SDHB SDHA
4 succinate dehydrogenase activity GO:0000104 8.8 SDHD SDHC SDHA

Sources for Lymph Node Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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