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MCID: LYM116
MIFTS: 46

Lymph Node Disease

Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lymph Node Disease

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MalaCards integrated aliases for Lymph Node Disease:

Name: Lymph Node Disease 12 15
Disorder of Lymph Node 73

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9942
NCIt 50 C35346
SNOMED-CT 68 76616003
UMLS 73 C0272394
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Summaries for Lymph Node Disease

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MalaCards based summary : Lymph Node Disease, also known as disorder of lymph node, is related to persistent generalized lymphadenopathy and sarcoidosis 1, and has symptoms including axillary lymph node pain, inguinal lymph node pain and inguinal lymph node tenderness. An important gene associated with Lymph Node Disease is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Carbon metabolism. The drugs Cisplatin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and thyroid, and related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Lymph Node Disease

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Diseases related to Lymph Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 persistent generalized lymphadenopathy 31.3 SDHA SDHAF2 SDHB SDHC SDHD TMEM127
2 sarcoidosis 1 10.4
3 spastic entropion 10.4 MMP1 MMP3
4 superior limbic keratoconjunctivitis 10.3 MMP1 MMP3
5 drug reaction with eosinophilia and systemic symptoms 10.3 CRP TNF
6 periodontitis, chronic 10.3 IL6 MMP1
7 tungiasis 10.3 IL10 TNF
8 microscopic polyangiitis 10.3 IL10 TNF
9 multifocal choroiditis 10.3 IL10 TNF
10 von hippel-lindau syndrome 10.2 SDHB SDHC SDHD
11 cowden disease 10.2 SDHB SDHC SDHD
12 cold agglutinin disease 10.2 CRP IL6
13 cryopyrin-associated periodic syndrome 10.2 CRP IL6
14 paragangliomas 1 10.2 SDHB SDHC SDHD
15 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
16 critical limb ischemia 10.2 IL6 TNF
17 juvenile ankylosing spondylitis 10.2 IL6 TNF
18 chondroma 10.2 SDHB SDHC SDHD
19 paraganglioma and gastric stromal sarcoma 10.2 SDHB SDHC SDHD
20 leukomalacia 10.2 IL6 TNF
21 cardiogenic shock 10.2 IL6 TNF
22 streptococcal toxic-shock syndrome 10.2 IL6 TNF
23 punctate inner choroidopathy 10.2 IL10 TNF
24 sporadic pheochromocytoma 10.2 SDHB SDHC SDHD
25 acute transverse myelitis 10.2 IL10 IL6
26 gingival overgrowth 10.2 IL6 MMP1 MMP3
27 carotid artery disease 10.2 CRP MMP1 MMP3
28 tropical endomyocardial fibrosis 10.2 IL10 TNF
29 endomyocardial fibrosis 10.2 IL10 TNF
30 carotid stenosis 10.1 CRP MMP1 TNF
31 fibrosarcoma 10.1 MMP1 MMP14 MMP3 TNF
32 scorpion envenomation 10.1 IL6 TNF
33 scrub typhus 10.1 CRP IL10 TNF
34 extra-adrenal pheochromocytoma 10.1 SDHAF2 SDHB SDHC SDHD
35 aspergillosis 10.1 IL10 TLR9 TNF
36 atherosclerosis susceptibility 10.1 CRP IL6 TNF
37 bacterial sepsis 10.1 CRP IL10 TNF
38 plasmodium falciparum malaria 10.1 IL10 TLR9 TNF
39 end stage renal failure 10.1 CRP IL6 TNF
40 pulmonary tuberculosis 10.1 IL10 TLR9 TNF
41 sleep apnea 10.1 CRP IL6 TNF
42 purpura 10.1 CRP IL6 TNF
43 overnutrition 10.1 CRP IL6 TNF
44 testicular disease 10.1 IL10 SDHD TNF
45 spondylitis 10.1 CRP IL6 TNF
46 juvenile rheumatoid arthritis 10.1 CRP IL6 TNF
47 spondyloarthropathy 1 10.1 CRP MMP3 TNF
48 joint disorders 10.1 IL6 MMP3 TNF
49 cholangitis 10.1 CRP IL6 TNF
50 septic arthritis 10.1 CRP MMP1 MMP3 TLR9

Graphical network of the top 20 diseases related to Lymph Node Disease:



Diseases related to Lymph Node Disease
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Symptoms & Phenotypes for Lymph Node Disease

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UMLS symptoms related to Lymph Node Disease:


axillary lymph node pain, inguinal lymph node pain, inguinal lymph node tenderness

MGI Mouse Phenotypes related to Lymph Node Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 EPCAM IL10 IL6 ITGAE ITPKC MMP14
2 homeostasis/metabolism MP:0005376 9.8 CRP EPCAM IL10 IL6 MMP1 MMP14
3 immune system MP:0005387 9.4 CRP EPCAM IL10 IL6 ITGAE ITPKC
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Drugs & Therapeutics for Lymph Node Disease

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Drugs for Lymph Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
2
Docetaxel Approved, Investigational Phase 3,Phase 2 114977-28-5 148124
3
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
4
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
5 Antimetabolites, Antineoplastic Phase 3
6 Antimetabolites Phase 3
7 Antimitotic Agents Phase 3,Phase 2
8 Estrogens Phase 3
9
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
10
Nivolumab Approved Phase 2 946414-94-4
11
Atezolizumab Approved, Investigational Phase 2 1380723-44-3
12
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
13
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
14
Doxil Approved June 1999 Phase 2 31703
15 Antibiotics, Antitubercular Phase 2
16 Anti-Bacterial Agents Phase 2
17 Immunologic Factors Phase 2,Not Applicable
18 Antibodies, Monoclonal Phase 2
19 Immunoglobulins Phase 2
20 Antibodies Phase 2
21 Immunosuppressive Agents Phase 2
22 Topoisomerase Inhibitors Phase 2
23 Alkylating Agents Phase 2
24 Antirheumatic Agents Phase 2
25 Antineoplastic Agents, Alkylating Phase 2
26
Inosine pranobex Approved Not Applicable 36703-88-5
27
Pancrelipase Approved, Investigational 53608-75-6
28 Antiviral Agents Not Applicable
29 Adjuvants, Immunologic Not Applicable
30 Anti-Infective Agents Not Applicable
31 Interferon-alpha Not Applicable
32 interferons Not Applicable
33 pancreatin

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes Completed NCT00287196 Phase 3
2 Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy Recruiting NCT01901094 Phase 3
3 Definitive Chemo-Radiotherapy for Regionally Advanced Head and Neck Cancer With or Without Up-front Neck Dissection Recruiting NCT02918955 Phase 3 Chemotherapy (Cisplatin)
4 Genetic Testing or Clinical Assessment in Determining the Need for Chemotherapy in Women With Breast Cancer That Involves No More Than 3 Lymph Nodes Active, not recruiting NCT00433589 Phase 3 anthracycline-based;docetaxel and capecitabine
5 Depsipeptide to Treat Patients With Cutaneous T-Cell Lymphoma and Peripheral T-Cell Lymphoma Completed NCT00007345 Phase 2 Romidepsin
6 CMP-001 in Combo With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease Recruiting NCT03618641 Phase 2 CMP-001
7 PEnile Cancer Radio- and Immunotherapy CLinical Exploration Study Recruiting NCT03686332 Phase 2 Arm A: Atezolizumab and Radiotherapy;Arm B: Atezolizumab
8 Fluorescence Targeted Pelvic Lymph Node Mapping Enrolling by invitation NCT03204994 Phase 1, Phase 2 Indocyanine Green
9 Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in Early Stage Breast Cancer Terminated NCT00636441 Phase 2 Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC)
10 Bronchoscopic Sampling Techniques in Sarcoidosis Unknown status NCT01836822 Not Applicable
11 A Study of Isoprinosine in Patients With Lymph Node Disease Completed NCT00002297 Not Applicable Inosine pranobex
12 The Safety and Effectiveness of Isoprinosine in Patients With Weakened Immune Systems and Lymph Node Disease Completed NCT00002296 Not Applicable Inosine pranobex
13 Evolution of Indications for Transbronchial Ganglionic Ultrasound Completed NCT03132883
14 Radiotherapy of Pelvic Lymph Nodes in High Risk Prostate Cancer - A Retrospective Analysis Completed NCT02998619
15 Recombinant Interferon Alfa-2b in Treating Patients With Melanoma Completed NCT01460875 Not Applicable
16 CT Detection of Metastatic Lymphadenopathy in Papillary Thyroid Cancer Completed NCT03359668 Not Applicable
17 Prospective Evaluation of the Diagnostic Efficacy of a EUS Guided FNB Needle (AQUIRE®) Recruiting NCT03621852
18 LYMPHA: Eliminating the Burden of Lymphedema in Patients Requiring Nodal Dissection Recruiting NCT03073096 Not Applicable
19 MR-guided RAdiotherapy to Breast With Dose Escalation to regionaL Lymph NodEs Recruiting NCT03405519 Not Applicable
20 Unlock the Cell: Castleman's Disease Flow Cytometry Study Recruiting NCT02853968
21 Role of Color Doppler Ultrasound in Lymphadenopathy Not yet recruiting NCT03760094 Not Applicable
22 Dynamic Contrast Enhanced Computed Tomography (CT) for Head and Neck Cancer Terminated NCT01549379 Not Applicable

Search NIH Clinical Center for Lymph Node Disease

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Genetic Tests for Lymph Node Disease

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Anatomical Context for Lymph Node Disease

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MalaCards organs/tissues related to Lymph Node Disease:

41
Lymph Node, Breast, Thyroid, Lung, Brain, Bone, Eye
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Publications for Lymph Node Disease

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Articles related to Lymph Node Disease:

(show all 38)
# Title Authors Year
1
ypT0N+: the unusual patient with pathological complete tumor response but with residual lymph node disease after neoadjuvant chemoradiation for esophageal cancer, what's up? ( 29997939 )
2018
2
Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer: What Is the Best Approach? ( 28107261 )
2017
3
Letter to the Editor on "Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer": What is the Best Approach? Int J Gynecol Cancer. 2017 Mar; 27(3): 543549. ( 28708789 )
2017
4
Axillary Ultrasound Accurately Excludes Clinically Significant Lymph Node Disease in Patients With Early Stage Breast Cancer. ( 26779976 )
2016
5
Unexpected lymph node disease in resections for pulmonary metastases. ( 25440271 )
2015
6
The prognosis of N2b and N2c lymph node disease in oral squamous cell carcinoma is determined by the number of metastatic lymph nodes rather than laterality: evidence to support a revision of the American Joint Committee on Cancer staging system. ( 24691658 )
2014
7
Is Minimal Residual Lymph Node Disease in Papillary Thyroid Cancer of Prognostic Impact? An Analysis of The Epithelial Cell Adhesion Molecule EpCAM in Lymph Nodes of 40 pN0 Patients. ( 23918549 )
2014
8
Critical analysis of the 2010 TNM classification in patients with lymph node-positive bladder cancer: influence of lymph node disease burden. ( 25027685 )
2014
9
Clinical feasibility and diagnostic accuracy of detecting micrometastatic lymph node disease in sentinel and non-sentinel lyph nodes in cervical cancer: outcomes and implications. ( 24505957 )
2014
10
The impact of lymph node disease in extremity soft-tissue sarcomas: a population-based analysis. ( 23806824 )
2013
11
Survival of patients with non-small cell lung cancer according to lymph node disease: single pN1 vs multiple pN1 vs single unsuspected pN2. ( 23378017 )
2013
12
Imaging response and residual metastatic axillary lymph node disease after neoadjuvant chemotherapy for primary breast cancer. ( 23846781 )
2013
13
Residual lymph node disease after neoadjuvant chemotherapy predicts an increased risk of lymphedema in node-positive breast cancer patients. ( 23689935 )
2013
14
Subcutaneous emphysema as the first relevant clinical sign of complicated tubercular lymph node disease in a child. ( 24094042 )
2013
15
Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer. ( 22120175 )
2012
16
Is Warthin's tumour of the parotid gland a lymph node disease? ( 21771031 )
2011
17
Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group. ( 21357792 )
2011
18
Micrometastatic sentinel lymph node disease: do patients benefit or suffer harm from axillary lymph node dissection? ( 19937389 )
2010
19
Minimal disease in the sentinel lymph node: how to best measure sentinel node micrometastases to predict risk of additional non-sentinel lymph node disease. ( 20532987 )
2010
20
Epithelial ovarian cancer relapsing as isolated lymph node disease: natural history and clinical outcome. ( 19077269 )
2008
21
Lymph node disease after radical prostatectomy. ( 17431370 )
2007
22
Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature. ( 17916603 )
2007
23
Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage IIIA-N2 Non-small-cell lung cancer: a Leuven Lung Cancer Group Study. ( 16849747 )
2006
24
High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease. ( 16649220 )
2006
25
Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma. ( 15912516 )
2005
26
Integrating radiological criteria into the classification of cervical lymph node disease. ( 10208675 )
1999
27
A review of Merkel cell carcinoma with emphasis on lymph node disease in the absence of a primary site. ( 9006679 )
1997
28
Lymph node disease with lymphocytic abnormal chromatin clumping in a myelodysplastic/myeloproliferative syndrome. ( 8459040 )
1993
29
The influence of pelvic lymph node disease on survival for stage I and II carcinoma of the cervix. ( 3816059 )
1987
30
The use of touch preparations (tissue imprints) in the rapid intraoperative diagnosis of metastatic lymph node disease in cancer staging procedures. ( 3891067 )
1985
31
Predominant B-lymphocyte deficiency in a case with lymph node disease resembling angioimmunoblastic lymphadenopathy. ( 6969020 )
1980
32
Normal anatomy and limitations in CT interpretation of lymph node disease. ( 262216 )
1979
33
Computed tomography of abdominal paraaortic lymph node disease: preliminary observations with a 6 second scanner. ( 404898 )
1977
34
Xeroradiography of axillary lymph node disease. ( 1118620 )
1975
35
Differential diagnosis of acute generalized lymphadenopathy and chronic abdominal lymph-node disease. ( 5600740 )
1967
36
Lymphography in metastatic lymph node disease. ( 6075530 )
1967
37
LYMPHOGRAPHY IN METASTATIC LYMPH NODE DISEASE. ( 14316207 )
1965
38
GIANT FOLLICULAR LYMPH NODE DISEASE. CLINICAL AND PATHOLOGICAL REVIEW OF SIXTY-FOUR CASES. ( 14320692 )
1965
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Variations for Lymph Node Disease

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Expression for Lymph Node Disease

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Search GEO for disease gene expression data for Lymph Node Disease.
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Pathways for Lymph Node Disease

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Pathways related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
IL-17 Family Signaling Pathways 65
Show member pathways
 12.24 IL6 MMP1 MMP3 TNF
2
Carbon metabolism 37
Show member pathways
 12.18 PGLS SDHA SDHB SDHC SDHD
3
Tuberculosis 37
12.15 IL10 IL6 TLR9 TNF
4
C-type lectin receptor signaling pathway 37
Show member pathways
 12.12 IL10 IL6 TLR9 TNF
5
Pyruvate metabolism and Citric Acid (TCA) cycle 66
Show member pathways
 11.99 SDHA SDHB SDHC SDHD
6
Th1 Differentiation Pathway 65
Show member pathways
 11.97 IL10 IL6 TLR9 TNF
7
Colorectal Cancer Metastasis 64
11.94 IL6 MMP1 MMP14 TLR9 TNF
8
TNF signaling pathway 37
11.87 IL6 MMP14 MMP3 TNF
9
Citrate cycle (TCA cycle) 37
Show member pathways
 11.82 SDHA SDHB SDHC SDHD
10
Matrix Metalloproteinases 1
Show member pathways
 11.79 MMP1 MMP14 MMP3 TNF
11
Amoebiasis 37
11.78 IL10 IL6 TNF
12
Rheumatoid arthritis 37
11.73 IL6 MMP1 MMP3 TNF
13
Innate Lymphoid Cell Differentiation Pathways 65
11.7 IL10 ITGAE TNF
14
Pertussis 37
11.67 IL10 IL6 TNF
15
Interleukin-4 and 13 signaling 66
11.61 IL10 IL6 MMP1 MMP3 TNF
16
Cell adhesion_ECM remodeling 22
11.56 MMP1 MMP14 MMP3
17
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.56 IL10 IL6 MMP3 TNF
18
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.47 IL6 MMP1 MMP3 TNF
19
Interleukin-10 signaling 66
11.44 IL10 IL6 TNF
20
IL-10 Pathway 64
11.27 IL10 IL6 TNF
21
Malaria 37
11.25 IL10 IL6 TLR9 TNF
22
Cytokines and Inflammatory Response 1
11.17 IL10 IL6 TNF
23
Dendritic Cells Developmental Lineage Pathway 65
10.97 EPCAM IL10 IL6 ITGAE TLR9 TNF
24
Overview of nanoparticle effects 1
10.89 CRP IL6 TNF
25
African trypanosomiasis 37
10.8 IL10 IL6 TLR9 TNF
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GO Terms for Lymph Node Disease

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Cellular components related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.55 ENSG00000255292 SDHA SDHB SDHC SDHD
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.02 ENSG00000255292 SDHA SDHB SDHC SDHD
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC

Biological processes related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 CRP IL10 IL6 TLR9 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.77 CRP IL6 TNF
3 electron transport chain GO:0022900 9.77 SDHA SDHB SDHC
4 cytokine-mediated signaling pathway GO:0019221 9.77 IL10 IL6 MMP1 MMP3 TNF
5 response to glucocorticoid GO:0051384 9.73 IL10 IL6 TNF
6 extracellular matrix disassembly GO:0022617 9.71 MMP1 MMP14 MMP3
7 positive regulation of interleukin-6 production GO:0032755 9.7 IL6 TLR9 TNF
8 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
9 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
10 collagen catabolic process GO:0030574 9.61 MMP1 MMP14 MMP3
11 response to molecule of bacterial origin GO:0002237 9.58 IL10 TLR9
12 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.58 TLR9 TNF
13 succinate metabolic process GO:0006105 9.57 SDHA SDHB
14 endothelial cell apoptotic process GO:0072577 9.55 IL10 TNF
15 negative regulation of interleukin-8 production GO:0032717 9.51 IL10 TLR9
16 negative regulation of interleukin-6 production GO:0032715 9.5 IL10 TLR9 TNF
17 negative regulation of cytokine secretion involved in immune response GO:0002740 9.49 IL10 TNF
18 positive regulation of neuroinflammatory response GO:0150078 9.48 IL6 TNF
19 positive regulation of chemokine production GO:0032722 9.43 IL6 TLR9 TNF
20 tricarboxylic acid cycle GO:0006099 9.43 ENSG00000255292 SDHA SDHAF2 SDHB SDHC SDHD
21 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
22 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
23 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.02 ENSG00000255292 SDHA SDHAF2 SDHC SDHD

Molecular functions related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.5 MMP1 MMP14 MMP3
2 electron transfer activity GO:0009055 9.46 SDHA SDHB SDHC SDHD
3 succinate dehydrogenase activity GO:0000104 9.26 SDHA SDHD
4 ubiquinone binding GO:0048039 9.26 ENSG00000255292 SDHB SDHC SDHD
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.92 SDHA SDHB SDHC SDHD
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Sources for Lymph Node Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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